dr. hari singh gour vishwavidyalaya, sagar - … · dr. hari singh gour vishwavidyalaya, sagar...

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Dr. Hari Singh Gour Vishwavidyalaya, Sagar M.Sc. Industrial CHEMISTRY SCHEME OF EXAMINATION

Semester I

Course Code Course Name Credits

ICH-C-121 Inorganic Chemistry 03

ICH-C-122 Organic Chemistry 03

ICH-C-123 Physical Chemistry 03

ICH-C-124 Quantum Chemistry and Chemical Bonding 03

ICH-C-125 A/B Mathematics Biology for Chemists 02

ICH-C-126 Laboratory Course in Inorganic Chemistry 02

ICH-C-127 Laboratory Course in Organic Chemistry 02

ICH-C-128 Laboratory Course in Physical Chemistry 02

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ICH-C-121

M.Sc. Industrial Chemistry Semester I

Inorganic Chemistry

Credits : 3 45 Hrs

1. Structure and Bonding : LCAO-MO theory, Metallic bonding, band theory, hydrogen

bonding, VSEPR model. Bonding in alloys, intermetallic compounds. Bonding in non-

transition element compounds.

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2. Group theory : Symmetry elements and symmetry operations, symmetry groups, molecular

dissymmetry and optical activity, molecular symmetry for compounds having co-

ordination number 2 to 9, matrix representation of groups, reducible and irreducible

representation, orthogonality theorem.

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3. Chemistry of Transition Elements : Ligand field theory, splitting of d-orbitals in

various fields, Jahn-Teller effect, types of magnetic compounds, magnetic properties

based on Crystal Field Theory, Thermodynamic effects in hydration, ligation and lattice

energy, quenching of orbital angular momentum, spin-orbit coupling, spin crossover.

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4. Spectroscopic states, Tanabe-Sugano and Orgel diagrams, selection rules, band

intensities and bandwidth, ACF-Theory, Nephelauxetic series, Charge-transfer spectra.

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5. Chemistry of Lanthanides and Actinides : Lanthanide contraction, spectral and

magnetic properties of lanthanides and actinides, shift reagents.

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Course Coordinator Dr. Y. Rohan

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ICH-C-122

M.Sc. Industrial Chemistry semester I

Organic Chemistry

Credits : 3 45 Hrs

Structure and Bonding : Hybridization, Strain, bond length and bond angles, Hückel

rule and concept of haromaticity, annulenes, fullerenes (C60) .

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Thermodynamics and Kinetics : Acids and bases, Hammett equation, – relationship, non-

classical carbonium ion, neighboring group participation, kinetic and thermodynamic

control.

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Stereochemistry : Chirality and isomerism in organic systems, conformational analysis of

simple cyclic and acyclic system, interconversion of Fischer, Newman and Sawhorse

projections, E-Z isomerism, R-S nomenclature, diastereomerism in acyclic and cyclic

systems, Newer methods of asymmetric synthesis (including enzymatic and catalytic

nexus), enantio- and diastereo selective synthesis, effect of conformation on reactivity.

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Elimination reaction : Mechanism and orientation, reactivity, mechanism and

orientation in pyrolytic elimination, Reactions–dehydration of alcohols, Shapiro

reaction, conversion of epoxide to olefines, dehalogenation of vicinal halide.

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Substitution Reaction : Mechanism and reactivity of nucleophilic substitution reaction,

orientation and reactivity in aromatic electrophilic substitution reaction.

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Addition Reaction : Mechanism and stereochemical aspects of addition reaction in carbon-

carbon and carbon-hetero multiple bonds, regio- and chemoselectivity, orientation and

reactivity. Mechanism of condensation reactions involving enolates- Aldol, Knoevenagel,

Claisen, Perkin and Stobbe reactions.

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Rearrangement reactions : Formation and stability of carbonium ions, carbanion, carbenes,

nitrenes, radicals and arynes. Rearrangement involving carbonation (Wagner-Meerwein,

Pinacol-Pinacolone rearrangement), Fries rearrangement, rearrangement of carbenes (Wolff

& Arndst-Eistert synthesis), rearrangement of nitrenes (Hoffman, Curtius, Schmidt,

Lossen, Beckman rearrangement).

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Course Coordinator Dr. Ratnesh Das

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ICH-C-123


Physical Chemistry

Credits : 3 45 Hrs

1. Chemical equilibrium : Free energy and entropy of mixing, partial molar properties,

chemical potential, Gibbs-Duhem equation, chemical equilibrium, temperature

dependence of equilibrium constant, phase diagram of one and two component

systems, phase rule, thermodynamic description of phase transitions, Clapeyron-

Claussius equation.

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2. Ideal and non-ideal solutions : Excess properties, activities, concepts of hydration

number, activities in electrolytic solutions, mean ionic activity coefficient, Debye- Hückel

treatment of dilute electrolyte solutions.

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3. Non-equilibrium thermodynamics : Postulates and methodologies, linear laws, Gibb's

equation, Onsager's theory 6

4. Statistical thermodynamics : Thermodynamics probability and entropy, ensembles,

distribution laws of MB, FD and BE, partition functions, rotational, translational,

vibrational and electronic partition functions for diatomic molecules, calculation of

thermodynamic functions and equilibrium constants, theories of specific heats of solids.

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5. Introduction, principles and industrial applications of physical methods :

electrochemical methods – polarography, potentiometry, electrogravimetry, conductance;

optical method- spectrophotometry

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6. Introduction to Nano Science : Methods of preparation nano particles, different reducing

agents, stability of nano particles, reactivities and catalytic activities of nano particles,

characterization of nano particles, different applications. Surfactant and Template :

Surfactants, types of surfactants, micelle formation, vesicle formation. Template and its

importance. Top down and bottom up approach in nano technology.

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7. Nano porous materials : Micro-, meso- and macro porous materials. Methods of synthesis,

encapsulation of nano particles and drugs in nano porous materials. Surface area of nano

porous materials. Applications.

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Course Coordinator Prof. Mrs. Archana Pandey

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ICH-C-124

M.Sc. Industrial Chemistry Semester I

Quantum Chemistry and Chemical Bonding

Credits : 3 45 Hrs 1. Mathematical Review : Basic vector algebra, matrix, determinant, eigen value equations,

quantum mechanical operators, orthogonal functions, Schmidt’s orthogonalization technique

Planck’s quantum theory, wave-particle duality, uncertainty principle, postulates of

quantum mechanics, Schrodinger equation, free particle, particle in a box, degeneracy,

harmonic oscillator, rigid rotator, the hydrogen atom, angular momentum, electron spin,

spin-orbit coupling.

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2. Approximate methods in quantum mechanics : The variation theorem, linear

variation principle and perturbation theory (first order and non-degenerate), application of

variation method and perturbation theory to the Helium atom, antisymmetry, Slater

determinant wave functions, term symbols and spectroscopic states.

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3. Born-Oppenheimer approximation : Hartree-Fock method, Brillouin theorem, Koopman’s

theorem, Roothan’s equations, models of chemical bonding- Molecular orbital (MO) and

Valence bond (VB) theories, application to diatomic molecules such as, H2 , H2+ etc.

Quantitative MO theory - Huckel π -electron theory and its application to ethylene,

butadiene and benzene, energy levels of di- and tri- atomic molecules. Walsh diagrams and

molecular geometry.

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Course Coordinator Dr.Vijay Verma

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ICH-C 125A M.Sc. Chemistry, Semester - I Mathematics for Chemists

Credits :2 30 Hrs s

1. Vectors in Matrix algebra

A. Vectors : Vectors , dot, cross and triple products etc.. The gradient, divergence and curl.

Vector calculus, Gauss’ theorem, divergence theorem etc.,

B Matrix Algebra : Addition and multiplication,; inverse, adjoint and transpose of

matrices, special metrics (symmetric, skew –symmetric, Hermitian, skew- Hermitian, unit diagonal ,

unitary etc ) and their properties. Matrix equations: Homogenous, non-homogenous linear

equations and conditions for the solution, linear dependence and independence.

Introduction to vectors spaces, vectors eigenvalues and eigenvectors, diagonalization,

determinants (examples from Huckel theory).

Introduction to tensors, polarizability and magnetic susceptibility as examples.

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2. Differential calculus

Functions, continuity and differentiability, rules for differentiation, application of differential

calculus including maxima and minima (examples related to maximally populated rotational

energy levels, Bohr’s radius and most probable velocity from Maxwell’s distribution etc), exact and

inexact differentials with their applications to thermodynamic properties.

Integral calculus, basic rules for integration, integration by parts, partial fraction and substitution,

Reduction formulae, applications of integral calculus.

Functions of various variables, partial differentiation, coordinate transformations (for example

Cartesian to spherical polar), curve sketching.

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3. Elementary Differentla equations

Variables – separable and exact first order differential equations, homogenous, exact and linear equations. Applications to chemical kenetics, secular equilibria, quantum chemistry etc. Solutions of differential equations by power series method, Fourier series, solution of harmonic oscillator and Legendre equation etc., speherical harmonics, second order differential equations and their solutions.

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4. Permutation and Probability

Permutations and combinations, probability and probability curves, average, root mean square and most probable errors, examples from the kinetic theory of gases etc, curve fitting (including least square fit etc.) with a general polynomial fit.

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Course Coordinator : Dr.K.S.Jatav

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ICH-C 125B

M.Sc. Chemistry, Semester – I Biology for Chemists

Credits :2 30 Hrs 1. Cell Structures and Functions : Structure of prokaryotic and eukaryotic cells, inter cellular

organelles and their functions, comparison of plant and animal cells. Overview of metabolic

processes – catabolism and anabolism. ATP – a biological energy currency. Origin of life –

unique properties of carbon, chemical evolution and rise of living systems, Introduction to

bio-molecules, building block of bio-macro molecules

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2. Carbohydrates : Conformation of mono saccharides, structure and functions of important

derivatives of mono- saccharides viz., glycosides, deoxy sugars, myoinositol, amino sugars. N

– acetyl muramic acid, sialic acid, di- saccharides and ploy saccharides,. Sturctural poly

saccharides, cellulose and chitin.storage poly saccharides – starch and glycogen.

Structural and biological functions of glucosaminoglycans or mucoploy saccharides.

Carbohydrates of glycoproteins and glycol lipids. Role of sugars in biological recognition.

Blood group substances. Ascorbic acid.

Carbohydrate metabolism – Kreb’s cycle, glycosis, glycogenisis and glycogenolysis, gluco

neogenisis, pentose phosphate pathway.

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3. Lipids : Fatty acids, essential fatty acids, structure and function of triglycerols, glycerol phospholipids. Sphingolipids, cholesterol, bile acids,

prosta glandins, lipoproteins – composition and function, role in atherosclerosis. Properties of lipd aggregates – micelles, bilayers liposomes and their possible biological functions. Biological membranes. Fluid mosaic

model of membrane structure. Lipid metabolism, β − oxidation of fatty acids.

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4. Amino acids, Peptides and Proteins : Chemical and enzymatic hydrolysis of proteins to peptides, amino and sequencing. Secondary structure of

proteins, forces responsible for holding of secondary structures, α -helix,

β − sheets , super secondary structure, triple helix structure of collagen. Tertiary structures of proteins- folding and domain structures. Quaternary structures. Amino acid metabolism – degradation and biosynthesis of amino acids, sequence determination: chemical / enzymatic / mass spectral , racemization/ detection. Chemistry of oxytocin and tryptophan releasing hormones (TRH).

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5. Nucleic Acids : Purine and pyramidine bases of nucleic acid, base pairing via H- bonding. Structure of ribonucleic acid (RNA) and di oxyribo nucleic acid (DNA), double helix model of DNA and forces responsible for holding it, an over view of replication of DNA, transcription, translation and genetic code. Chemical synthesis of mono and trinucleoside.

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Course Coordinator : Dr. Payal Mahobia

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ICH-C-126


Laboratory Course -Inorganic Chemistry

Credits : 2

Quantitative analysis of constituents in ores and alloys and Indutrial inoragnic materials

a). Brass; b). Bronze ; c). Pyrolusite

Simultaneous Estimations by spectrophotometry; atomic absorption spectroscopy and HPLC.

Spectrophotometry- Determination of λmax, mole ratio, and unknown concentrations

Determination of two metal ion combination in given sample by gravimetric and volumetric methods Course Coordinator Dr.Yadvendra Rohan

ICH-C-127


Laboratory Course - Organic Chemistry

Credits : 2

Separation, purification and identification of compounds of binary mixtures using TLC, chemical

tests.

IR spectra to be used for functional group identification.

Determination of Iodine and saponification value of oil/fat sample.

Organic synthesis : Nitration, Bromination and etc (involving one, two or more steps

Course Coordinator Dr.Ratnesh Das

ICH-C-128


Laboratory Course -Physical Chemistry

Credits : 2

•••• Determination of molecular weight of non-volatile substances (glucose,urea etc.)

•••• Determination of molecular weight of non-volatile substances (such as naphthalene, anthracene and

acamphor etc.) by cryoscopic methods using benzene as solvent.

•••• Determine the freezing point depression on constant camphor using naphthalene as solute.

Determine molecular weight.

•••• Determine the rate constant of hydrolydsis of metyl acetate catalysed by an acid.

•••• Determine the rate constant of hydrolydsis of metyl acetate catalysed by an acid in miscellar media.

•••• Determine kinetics of hydrolysis of ethyl acetate by NaOH (spopnification of an ester)

conductometrically.

•••• To investigate the inversion of cane sugar in presence of an acid by polarimetry.

•••• To investigate the complex ion formation between Fe(II) and thiocynate ion.

•••• To construct the phase diagram of : a). aniline hexane, b). phenol water, c). methyl alcohol-

cyclohexane; glycerol – m-toludine.

•••• Study the kinetics of reaction between Potassium persulphate and potassium iodide. A). determine

rate constant and order of reaction, b). study the influence of ionic strength.

•••• Surfactant enhanced solublisation. Course Coordinator Prof. Archana Pandey

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Recommended Books

ICH-121: Inorganic Chemistry-I Books Suggested 1. Advanced Inorganic Chemistry, F.A. Cotton and G. Wilkinson, John Wiley.

2. Inorganic Chemistry, J.E. Huhey, Harpes & Row.

3. Chemical Application of Group Theory F.A. Cotton.

4. Inorganic Chemistry, D.F. Shriver, P.W. Atkins and C.H. Langford, Oxford University Press.

ICH-122: Organic Chemistry-I Books Suggested

1. Advanced Organic Chemistry, Reaction Mechanism and Structure, Jerry March,

John Wiley.

2. A Guide Book to Mechanism in Organic Chemistry, Peter Sykes, Longman.

3. Principles in Organic Synthesis, R.O.C. Norman and J.M. Coxon.

4. Organic Chemistry, 7 Edn. T.W Graham Solomons and Craig B Fryhle, John

Wiley & Sons, t h Inc, 2000,New York

ICH-123: Physical Chemistry-I Books Suggested: 1. Physical Chemistry, P.W. Atkins, ELBS.

2. Encyclopedia of Physical Chemistry, Vol I – IV, J.C. Moore.

3. Physical chemistry, I.N. Levine, McGraw Hill.

4. Physical chemistry, G.W. Castellan, Narosa.

ICH-124: Quantum Chemistry and Chemical Bonding Books Suggested: 1. Quantum Chemistry, Ira N. Levine, Prentice Hall.

2. Introduction to Quantum Chemistry, A.K. Chandra, Tata McGraw Hill.

ICH-126: Physical Chemistry Laboratory Books Suggested: 1. Practical Physical Chemistry, A.M. James and F.E. Prichard, Longman.

2. Findley’s Practical Physical Chemistry, B.P. Levitt, Longman.

3. Practical Physical Chemistry, Jadav.

4. Experiments in Physical Chemistry, Shoemaker.

5. Experimental Physical Chemistry, R.C. Das and B. Behera, Tata McGraw Hill.

ICH-127: Inorganic Chemistry Laboratory : Books Suggested

1. Vogel’s Textbook of Quantitative Analysis, J. Bassett, R.C. Denney, G.H. Jeffery and J.

Mendham, ELBS.

2. Synthesis and Characterisation of Inorganic Compounds, W.L. Jolly, Prentice Hall.

3. Inorganic Experiments, J. Derek Wollins, VCH.

4. Microscale Inorganic Chemistry, Z. Szafran, R.M. Pike and M.M. Singh, J. Wiley.

5. Practical Inorganic Chemistry, G. Marr and B.W. Rockett, Van Nostrand.

ICH-128 Organic Chemistry Laboratory : Books Suggested

1. Experiments and Techniques in Organic Chemistry, D. Pasto, C.

Johnson and M. Miller, Prentice Hall. ---

2. Macroscale and Microscale Organic Experiments, K.L. Williamson,

D.C. Heath.

3. Vogel's Textbook of Practical Organic Chemistry, A.R. Tatchell, John

Wiley.

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Dr. Hari Singh Gour Vishwavidyalaya, Sagar M.Sc. Industrial Chemistry

Semester II Scheme of Examination


ICH-C-221 Inorganic Chemistry 03

ICH-C-222 Organic Chemistry 03

ICH-C-223 Physical Chemistry 03

ICH-C-224 Principles and Applications of Spectroscopy 03

ICH-C-225 Computer for Chemists 02

ICH-C-226 Laboratory Course in Inorganic Chemistry 02

ICH-C-227 Laboratory Course in Organic Chemistry 02

ICH-C-228 Laboratory Course in Physical Chemistry 02

ICH-C-229 Laboratory Course in Computers for Chemists 01

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ICH-C-221

M.Sc. Industrial Chemistry semester II

Inorganic Chemistry

Credits : 3 45 Hrs

1. Metal-ligand equilibria and Reaction Mechanism of Inorganic Complexes:

Stepwise and Overall Formation Constants; Factors affecting the stability of metal-complexes

(with reference to metal ion and ligand ), Chelate Effect and its thermodynamic origin;

determination of binary formation constants by Spectrophotometry and pH-metry.

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2. Substitution reactions-

Dissociation and association pathways; Kinetics substitution in Octahedral and Square

planar complexes, trans effect; mechanism of one electron transfer reactions; Marcus-Hush

theory; Stereochemical non-rigidity and Fluxional molecules.

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3. Organometallics:

Synthesis, structure and bonding of metal complexes with unsaturated molecules; Metal

carbonyl hydrides and metal carbonyl Clusters, LNCC and HNCC; Compounds with metal-

metal multiple bonds; insertion and extrusion reactions; Catalytic reactions of alkenes:

isomerization, hydrogenation, carbonylation, hydroformylation and polymerization; Fischer-

Tropsch process.

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4. Inorganic polymers:

Polysiloxanes, polysilanes, polyphosphazenes –synthesis, structure, properties and

applications; Coordination polymers.

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5. Bioinorganic Chemistry:

Essential and trace elements in biological systems; Na,/ K pump; Heme proteins-

haemoglobin , myoglobin and Cytochrome-c; Metalloenzymes: Zn enzymes-

carboxypeptidase, carbonic-anhydrase;

Metal-chelates in medicine: metals used for diagnosis and chemotherapy with particular

reference to anticancer drugs.

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Course Coordinator Dr.Yadvendra Rohan

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ICH-C-222


Organic Chemistry Credits : 3 45 Hrs

1. Reduction : Catalytic hydrogenation and dehydrogenation, dissolving metal reduction,

metal hydride reduction of carbonyl compounds and other functional groups, Meerwein-

Pondorf Verley reduction, hydroboration and related reaction including reaction of alkyl

borane and tributyltin hydride, Wolff-Kishner reduction, reduction of diimide.

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2. Oxidation : Oxidation with Cr and Mn compounds: oxidation of alcohol, aldehyde,

C=C, C-H bonds in organic molecules, Pyridinium chloro chromate (PCC), Oxidation

with peracids and other peroxides: C=C, Sharpless epoxidation, Baeyer-Villiger oxidation.

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3. Other types : Prevost and Woodward hydroxylation, cis - and trans - hydroxylation, glycol

cleavage reagent; KMnO4 , OsO4 , HIO4 , Pb(oAc)4 , mercuric acetate; SeO2 oxidation of

allylic C-H bond.

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4. Pericyclic reaction : Orbital symmetry and pericyclic reaction, selection rules and

stereochemistry of electrocyclic reaction, cycloaddition and sigmatropic shift, Sommelet

Hause, Cope and Claisen rearrangement.

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5. Free radical reactions : Types of free radical reactions, free radical substitution mechanism,

mechanism at an aromatic substrate, reactivity in the attacking radicals, the effect of solvents

on reactivity, allylic halogenation (NBS), oxidation of aldehydes to carboxylic acids, auto-

oxidation.

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6. Photochemistry : Introduction to photochemical reactions, cis-trans isomerisation,

Paterno-Buchi reaction, Norrish type I & II reaction, photoreduction of Ketones,

dipimethane rearrangement, photochemistry of arenes, Barton reaction.

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7. Selected organic reactions and reagents : Favorski, Stork-enamine, Michael addition,

Mannich, Hofmann-Loffler-Freytag, Shapiro, Chichibabin and Wittig reaction, Robinson

annulation, Gilman’s reagent,

Lithium dimethyl cuprate, Dicyclohexyl carbodimide, Lithium diisopropylamine, 1,3–

dithiane (reactivity umpolung), Trimethyl silyl iodide, Baker Yeast, Phase-transfer catalysts.

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ICH-C-223


Physical Chemistry

Credits : 3 45 Hrs

1. Reaction Kinetics : Methods of determinations of reaction rates laws, mechanism of

photochemical chain and oscillatory reactions, Collision theory of reaction rates, steric

factor, treatment of unimolecular reactions, Activated complex theory, comparison of

results with Eyring and Arrhenius equations, Ionic reactions: salt effect, Homogeneous

catalysis and Michaelis- Menten kinetics, heterogeneous catalysis.

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2. Fast reactions : Luminescence and energy transfer process, study of fast reactions by

stopped flow method, relaxation method, flash photolysis, T and P jump and nuclear

magnetic resonance method.

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3. Nano Materials: Quantum dots, band gap, excitons, quantum confinement effect, Bhor’s

radius. Applications of Quantum dots. Introductory ideas of Fullerence, nano tubes, nano

wires, nano cones, nanorids and their applications.

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4. Fuel Cell Technology: Simple Grove’s fuel cell, efficiency of fuel cell, solid oxide fuel cell

(SOFC). Anode, cathode, electrolyte and interconnect in SOFC, Applications of fuel cells.

Solid state battery, corrosion and its prevention.

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5. Macromolecules: Number average and weight- average molecular weights,

determination of molecular weight, thermodynamics and kinetics of polymerization,

stereochemistry and mechanism of polymerization.

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6. Solids: Dislocations in solids Schottky and Frenkel defects, Electrical properties of

solids, insulators and semiconductors, band theory of solids, solid-state reactions.

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Course Coordinator Prof. Archana Pandey

ICH-C-224


Principles and applications of Spectroscopy Credits : 3 45 Hrs 1. Basic principles : Interaction of matter and radiation, time-dependent perturbation theory, uncertainty

relation and natural line width, transition moment, selection rule for electric dipole, magnetic

dipole, electric quadrupole transitions. Pure rotational, vibrational and vibrational-rotational spectra

of diatomic molecules. Pure vibrational spectra of polyatomic molecules: Normal coordinate

analysis, symmetry of normal coordinates; group theoretical derivation of selection rules, Fermi

resonance. Theory of Raman scattering, rotational, vibrational and vibrational-rotational Raman

spectra of molecules.

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2. Electronic spectra : Frank-Condon principle, electronic spectra of polyatomic molecules,

electronic transitions, change of molecular shape on electronic excitation, selection rule,

intensity and oscillator strengths.

PES : Photoelectron spectroscopy and Laser spectroscopy.

Nuclear Magnetic Resonance : Origin of chemical shifts, spin-spin coupling, relaxation processes,

NOE, 2D- NMR.

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3. EPR spectroscopy : origin of g-shifts and hyperfine coupling, line shape.

Mossbauer spectroscopy : Isomer shift, quadrupole interactions, effect of magnetic field

X-ray methods : X-ray diffraction, X-ray fluorescence and X-ray absorption and X-ray emission

spectroscopy.

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Course Coordinator Dr. Vijay Verma

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ICH-C 225 M.Sc. Chemistry, Semester – II Computers for Chemists

Credits :2 30 Hrs 1. Introduction to computers and computing

Basic structure and functioning of computers with a PC as an illustrative example. Memory, I/O

devices. Secondary storage. Computer languages. Operating systems with DOS as an example.

Introduction to Unix and Windows, data processing, principles of programming. Algorithms and

flow charts.

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2. Computer programming in FORTRAN/ C/ BASIC

(The language features are listed here with respect to FORTRAN. The instructoir may choose

another language such as BASIC or C and the features mey be replaced appropriately). Elements

of the computer language. Constants and variables. Operations and symbols. Expresion.

Arithmetic assignment ststement. Input and Out put . Format statement. Termination

statement. Branching statements such as IF or GO TO statements. LOGICAL variables. Double

precision variables. Subscripted variables and DIMENSION. DO statement. FUNCTION and

SUBROUTINE. COMMON and DATA ststements.(Note: Students learn these programming logics

by “hand on ” experience on a personnel computer ).

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3. Programming in Chemistry :

Development of small computer codes involving simple formulae in chemistry, such as van der

Waal equation, pH titration, kinetics, radioactive decay. Evaluation of lattice energy and ionic

radii from experimental data. Linear simultaneous equation to solve secular equation with

Huckel theory. Elementary structural features such as bond lengths, bond angles, dihedral

angles etc of molecules extracted from a data base such Cambrige data base.

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4. Use of Computer Programmes :

The students will learn to how to operate a PC and how to run stsndard programmes and

packages. Execution of linear regression such as X Y plot, numerical integration and

differentiation as wel as differential equation solution programmes. Monte Carlo and molecular

dynamics. Programmes with data preferably from physi9cal chemistry laboratory. Further, the

students will operate one or two or more packages such as MATLAB, EASYPLOT, EXCEL, FOXPRO

and Word Processing software – MS Word and Powerpoint.

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Course Coordinator : Prof. S.N.Limaye

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ICH-C 226 M.Sc. Chemistry Semester II

Laboratory Course – Inorganic Chemistry

Credits-02 Qualitative and Quantitative Analysis : Chromatography Separation of Cations and Anions by (a). Paper Chromatography (b). Column chromatography – ion exchange. Preparations : Preparation of selected inorganic compounds and their studies by IR, electronic spectra, Mossbaur, ESR and magnetic susceptibility measurements. Handling of air and moisture sensitive compounds

VO(acac)2 TiO(C9H8NO)2. 2(H2O) cis- K[Cr(C2O4)2(H2O)2] Na [Cr(NH3)2(SCN)4] cis- K[Cr(C2O4)2(H2O)2 Mn (acac)3 K3[Fe(C2O4)3] Prussian Blue, Turnbull’s Blue Co(NH3)6][Co(N)2)6] cis – [Co(trien)(NO2]Cl.H2O Hg[Co(SCN)4] [Co(Py)2Cl2 [Ni(NH)6)Cl2 Ni (dmg)2 [Cu(NH3)4]SO4.H2O

Dr. Yadvendra Rohan

ICH-C-227


Laboratory Course - Organic Chemistry

Credits : 2

Organic Synthesis : Cannizziro reaction : 4-Chlorobenzaldehyde as substrate,

Friedel Crafts Reaction ; β-benzoylpropionic acid from succinic anhydride and benzene, Aromatic electrophilic

substitutions : Synthesis of p-nitroaniline and p- bromoaniline.

Acetoacetic ester condensation: Synthesis of ethyl-n-butyl acetotate by A.E.E. condensation.

The products may be Characterized by Spectral Techniques.

Quantative Analysis : Determination of the percentage or number of hydroxyl groups in organic compounds by

acetylation method.

Estimation of amines / phenols using bromate bromide solution or acetylation method. Course Coordinator Dr. Ratnesh Das

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ICH -C 228

M.Sc. Industrial Chemistry

Laboratory Course – Physical Chemistry Credits ; 2

PHASE EQUILIBRIA

Detemine the congruent composition and temperature of binary system (e.g. diphenylamine -

benzophenone system?

To construct the phase diagram for the three component system (e.g.chloroform, acetic acid and water).

Determine the triangular phase diagram of ethanol, benzene and water?

CHEMICAL KINETICS

Determine the rate constant of the reaction between potassium persulphate and potassium iodide (KI) at

room temperature?

Determine the velocity constant of hydrolysis of an ester / ionic reaction in miceller media?

Determine the primary salt effect on the kinetics of ionic reactions and testing of the Bronsted

relationship?

CONDUCTOMETRY

Determine the solubility and solubility product of the given sparingly soluble salt conductometrically?

Determine the activity coefficient of Zn2+

ion in the solution of 0.002M ZnSO4 using Debye – Huckel

limiting law?

POTENTIOMETRY/pH METRY

Determine the strengths of strong acid and weak acid in the given mixture of both by titrating it with

standard NaOH solution potentiometrically.

Determine the temperature dependence of EMF of the cell?

Acid – base titration in a non-aqueous medium using pH meter.

Determination of dissociation constant of mono/dibasic acids by Albert – Serjeant method.

SOLUTION

Determine the degree of dissociation of weak electrolyte and to study the

deviation from ideal behaviour that occurs with strong electrolyte?

POLARIMETRY

Determine the concentration of unknown Sugar solution using polarimeter?

Course oordinator Prof. Mrs. Archana Pandey

ICH-C 229

M.Sc. Industrial Chemistry, Semester - II

Laboratory Course - Computer for Chemists

Credits :1 15 Hrs The students will learn to how to operate a PC and how to run standard programmer and

packages – for chemistry applications.

Execution of linear regression such as X Y plot, numerical integration and differentiation as well

as differential equation solution programmer .

Monte Carlo and molecular dynamics – PC Model, Programming with data preferably from

physical chemistry laboratory-Basic/C/Fortran.

Operation of one or two or more packages such as EXCEL, Word Processing software – MS Word

and Powerpoint, MATLAB, EASYPLOT, FOXPRO.

Course Coordinator : Prof. S.N.Limaye

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Books Suggested: Inorganic Chemistry 1. Advanced Inorganic Chemistry, F.A. Cotton and G. Wilkinson, John Wiley.

2. Inorganic Chemistry, J.E. Huhey, Harpes & Row.

3. Chemistry of the elements, N.N. Greenwood and A. Earnshaw, Pergamon.

4. Inorganic Electronic Spectroscopy, A.B.P. Lever, Elsevier.

5. Magnetochemistry, R.L. Carlin, Springer-Verlag.

Organic Chemistry : Books Suggested: 1. Advanced Organic Chemistry, Reaction Mechanism and Structure, Jerry March, John Wiley.

2. Modern Synthetic Reaction, H.O. House, W.A. Benjamin.

3. Principles in Organic Synthesis, R.O.C. Norman and J.M. Coxon.

4. Reactions Mechanisms & Problems in Organic Chemistry, P Chattapadhyay, 1 Edn, Asian,

Books Private Limitted, New Delhi

5. Organic Synthesis, Michael B Smith, McGraw Hill, 2 , Edn, 2004, NewYork.

Physical Chemistry : Books Suggested 1. Modern Electrochemistry, Vol. I & II, J.O.M. Bokris and A.K.N. Reddy, Plenum

2. Chemical Kinetics, K.J. Laidler, McGraw Hill.

3. Physical Chemistry, P.W. Atkins, ELBS.

4. Encyclopedia of Physical Chemistry, Vol I – IV, J.C. Moore.

5. Solid State Chemistry, D.K. Chakrabarty, New Age Publishers.

6. Physical Chemistry of Surfaces, Wiley, A.W. Adamson.

7. Textbook of Polymer Science, F.W. Billmeyer, Wiley.

Spectroscopy : Books Suggested: 1. Fundamentals of Molecular Spectroscopy, C.N. Banwell, Tata McGraw Hill.

2. Physical Methods for Chemistry, R.S. Drago, Saunders Company

3. Infrared and Raman Spectra: Inorganic and Coordination Compounds, K.Nakamoto, Wiley.

4. Solving problems with NMR Spectroscopy, Atta-ur-Rahman, Academic Press, Elsevier, 2005.

Computers in Chemistry: Books Suggested:

1. Computational Chemistry, A. C. Norris, John Wiley.

2. A Handbook of Computational Chemistry, Tim Clark, John Wiley and Sons, 1985.

3. Computer Programming in FORTRAN 77, V. Rajaraman, Prentice Hall of India, New Delhi, 1995.

4. Computer Oriented Numerical Methods, Author: V. Rajaraman, Prentice Hall of India.

5. Computer Software Applications in Chemistry, Peter C. Jurs, John Wiley and Sons, New York,

1986.

Organic Practicals : Books Suggested: 1. Experiments and Techniques in Organic Chemistry, D. Pasto, C. Johnson and M. Miller, Prentice

Hall.

2. Macroscale and Microscale Organic Experiments, K.L. Williamson, D.C. Heath.

3. Vogel's Textbook of Practical Organic Chemistry, A.R. Tatchell, John Wiley.

18

Dr. Hari Singh Gour Vishwavidyalaya, Sagar M.Sc. Industrial Chemistry SCHEME OF EXAMINATION

Semester III


ICH-C-321 Industrial Polymer 03

ICH-C-322 Industrial Chemicals 03

ICH-C-323 Chemistry of Natural Products 03

ICH-E-324 Applied Electrochemistry 03

ICH-E-325 Analytical Chemistry 03

ICH-E-326 Medicinal Chemistry 03

ICH-C-327 Laboratory Course Common to all 02

ICH-E-3284 Laboratory Course – in Electrochemistry 02

ICH-E-3285 Laboratory Course – in Analytical Chemistry 02

ICH-E-3286 Laboratory Course – in Medicinal Chemistry 02

19

ICH-C-321

M.Sc. Industrial Chemistry semester III

Industrial Polymers

Credits : 3 45 Hrs

1. Types of polymerization: classification, chain growth reactions (radical, ionic and Ziegler-

Natta Polymerization) and step growth reactions (poly addition, reversible and irreversible

polycondensation.

Polymer Solution: Polymer Solubility and its thermodynamics, Composition of dissolved

polymer chains, fractionation of polymers by solubility.

10

8

2. Commercial polymers-: Polyenes; Preparation, properties and uses of poly-thene,

polypropene, polyvinylchloride, polystyrene and polybutene. Effect of stereochemistry on the

structure and properties of polymers.

10

3. Polymer Rheology and Morphology: Introduction stress and strain, ideal elastic solid,

Newtonian and non- Newtonian fluid. Apparent viscosity, the power, low molecular hole

concept, Wessenberg effects,Rheological properties of fluid, melt fracture and irregular, time

dependent flow, viscoelastic behavior, mechanical model of a viscoelastic material relaxation

enhancement under constant stress. Hysteresis, creep and relaxation of typical plastics.

12

4. X- ray diffraction: Structural studies of polymer crystal structure, ESCA to study surface

and bonding in polymers.

5

Course Coordinator Prof. O.P.Chourasia

ICH-C -322


Industrial Chemicals

Credits : 3 45 Hrs 1. Petrochemicals: Chemicals from paraffin’s, olefins, acetylenes and aromatics. Chemicals

from natural gas,

8

2. Greases-: Structure, mechanical properties of greases in general. Types of greases,

preparation, properties and uses of sodium, calcium, lithium aluminum and lead base greases.

Greases- : Mixed based Lubricating greases.

7

3. Lubrication oils-: Methods of Preparation- production, properties and uses of refrigeration

oils, cutting oils, transformer oils and gear oil.

Additives for lubrication oils and greases (antioxidant; passivators, pour point depressants,

detergents, adhesives and emulsifiers.

8

4. Industrial organic synthesis: Introduction, raw materials and basic processes. Petroleum

products as raw materials in industrial synthesis. Synthesis of methanol, ethanol,

acetaldehyde, glycol, glycerol, acetone 1,3 butadiene.

7

5. Corrosion-: Corrosion testing, corrosion by water and steam, atmospheric corrosion,

corrosion by soil, oxidizing acids, reducing acid, CO2, H2S, chlorine and salts.

Corrosion current and corrosion potential, corrosion measurement methods: Weight loss

method, electrochemical approach, corrosion rate at short time intervals.

Corrosion studies on specific metals in different mediums (acid / neutral / alkaline

environment): C-steel, Fe-Steel, Copper, Aluminum...

12

6/ Corrosion Hazards and its industrial implications. 3

Course Coordinator Prof. R. N. Yadav

20

ICH-C -323


Chemistry of Natural Products

Credits : 3 45 Hrs 1. Terpenoids and Carotenoids : Classification, nomenclature, occurrence, isolation, general methods

of structure determination, isoprene rule.

Structure determination, stereochemistry, biosynthesis and synthesis of the following

representative molecules; citral, α-Terpeniols, Menthol, Zingiberene, Santonin, Phytol and β-

carotene, Porphyrins : Structure and synthesis of Haemoglobin and Chlorophyll

Perfumes: Introduction and synthesis of some important synthetic chemicals used in perfume

industry- coumarin, ionone etc.

8

2. Alkaloids : Definition, nomenclature and physiological action, occurrence, isolation,general methods

of structure elucidation, degradation, classification based on nitrogen heterocyclic rings, role of

alkaloids in plants. Structure, seterochemistry.

Synthesis and biosynthesis of the following: Nicotine, Quinine and Morphine.

15

3. Steroids : Occurrence, nomenclature, basic skeleton, Diel hydrocarbon and stereochemistry.

Isolation, structure determination and synthesis of Cholesterol, Bile acids, Testosterone, sterone,

Progesterone. Biosynthesis of steroids.

Prostaglandins : Occurrence, Classification, nomenclatur, biogenesis and physiological effects,

Pyrthroids and Rotenones ; Synthesis and Reacation of Pyrthroids and Rotenones

12

4. Plant Pigments Occurrence, nomenclature, general methods of isolation, Synthesis and structure

determinaton, of Quercetin, Myrcetin, Quercetin-3-glucoside. Butein, Cyanidin-3,5-diglucoide,

Hirustidin, change of colours in cyandin with pH Variation. Biosynthesis of flavanoids:Acetate

pathway and Shikimic acid pathway.

7

Course Coordinator Prof. S.P.Shrivastava

21

ICH-E-324


Applied Electrochemistry

Credits : 3 45 Hrs

1. Ion-solvent Interaction:

Ion-solvent Interaction, structure of liquids, dissociation theory of Ion-solvent Interaction,

Solvation and hydration of ions.

8

2. Electrokinetic phenomenon : Electrokinetic effects, the electrical double layer and its

structure, Stern theory of the double layer, Electro-osmosis, streaming potential, influence of

ions on electrokinetic phenomenon.

7

3. Solid State electrochemistry: Fuel cells and solid state batteries, Introductory ideas of semi-

conductor electrochemistry.

8

4. Newer Polarographic techniques: General treatment and applications of the following

techniques: (a). Oscilographic polarography; (b). AC polarography ; (c). Pulse polarography,

NPP and DPP

7

5. Polarographic study of Metal Complexes: Effect of ligand on polarographic waves,

determination of stability constants of complexes (in reversible diffusion- controlled systems)

by Lingane’s method, Deford and Hume’s method, Schaap and McMasters method.

Determination of metal ions (by masking) in multicomponent systems.

8

6. Environmentally oriented electrochemistry : The environmental situation, the

electrochemical advantages. The solar-hydrogen solution. The CO2 fixing, Photo-

electrochemical reduction of CO2. Electrochemical removal of wastes: (i) Waste water (ii)

Sulphur dioxide (iii) Removal of metals (iv) Destruction of nitrates.

Electrochemical treatment of low level nuclear wastes. Bactericidal effects.

7


22

ICH-E-325

M.Sc. Chemistry semester III

Advanced Analytical Chemistry Credits : 3 45 Hrs

1. Classification and Sample Preparation : Classification of Analytical methods–classical and

instrumental. Types of instrumental analysis. Volumetric analysis glassware calibration, Samples and

sample preparation - Introductory idea of sampling, dissolution and decomposition. Gravimetric

techniques. Reagents in analysis and their application

5

2. Errors and Evaluation : Definition of terms in mean and median. Precision-standard déviation, relative

standard déviation. Accuracy-absolute error, relative error. Type of error in experimental data

determinate (systematic), indeterminate (or random) and gross, Sources of errors and the effects

upon the analytical results. Methods for reporting analytical data. Statistical evaluation of data-

indeterminate errors. The uses of standard statistical packages.

6

3. Food Analysis ; Moisture, ash, crude protein, fat crude fibre, carbohydrates, calcium potassium,

sodium and phosphate. Food adulteration-common adulterants in food, contamination of food stuffs.

Microscopic examination of foods for adulterants. Pesticide analysis in food products. Extraction and

purification of sample, HPLC. Gas chromatography for organophosphates. Thin-layer chromatography

for identification of chlorinated pesticides in food products.

8

4. Analysis of Water Pollution : Origin of waste water, types, water pollutants and their effects. Sources

of water pollution domestic, industrial, agricultural soil and radioactive wastes as sources of pollution.

Objectives of analysis-parameter for analysis-colour, turbidity, total solids, conductivity, acidity,

alkalinity, hardness, chloride, sulphate, fluoride, silica, phosphates and different forms of nitrogen.

Heavy metal pollution public health significance of cadmium, chromium copper, lead, zinc,

manganese, mercury and arsenic. General survey of instrumental technique for the analysis of heavy

metals in aqueous systems. Measurement of DO, BOD and COD. Pesticides as water pollutants and

analysis. Water pollution laws and standards.

9

5. Analysis of Soil, Fuel, Body Fluids and Drugs : Analysis of soil: moisture, pH, total nitrogen,

phosphorus, silica, lime, magnesia, manganese, sulphur and alkali salts.

Fuel analysis: solid liquid and gas. Ultimate and proximate analysis heating values grading of coal.

Liquid fuels flash point aniline point octane number and carbon. Residue. Gaseous fuels producer gas

and water gas calorific value.

Clinical chemistry: Composition of blood collection and preservation of samples Clinical analysis.

Serum electrolytes, blood glucose blood urea nitrogen, uric acid albumin, globulins, barbiturates, acid

and alkaline phosphates, immunoassay principles of radio immunoassay (RIA) and applications. The

blood gas analysis trace elements in the body.

Drug analysis; Narcotics and dangerous drugs. Classification of drugs. Screening by gas and thin layer

chromatography and spectrophotometric measurements.

12

3

2

Course Coordinator Prof. S. N. Limaye

23

ICH-E-326


Medicinal Chemistry Credits : 3 45 Hrs

1. Drug therapy of allergies, general idea about drug acid in ophthalmic d isorders;

Principal of toxicology and treatment of poisoning: cyanide, salicylic acid, organ phosphorous

compounds.

10

2. Anticonvulsants and antiepileptic drugs- Classification, pharmacology, mode of action and adverse

effects of drugs used in convulsive and epileptic disorders. Drug used in depression, mania and CNS

degenerative disorders.

Diuretic and anti-diuretic drugs, drug used in therapy of migraine, CNS stimulant, hallucinogens.

10

3. Composition and functions of blood R.B.C. W.B.C., Haemoglobin, platelets and plasma Leukemia ,

blood coagulation factor and its mechanism.

General description, collection preservation, physical chemical and microscopic examinations of

stool, sputum and semen.

10

4. Pharamacokinetics and Pharmacodynamics: Introduction, uses of pharmacokinetic and

pharmacodynamics in drug development, drug receptor. Theories, effect of drugs and drug doses.

5

5. Antineoplastic Agents: Introduction, cancer chemotherapy, special problems, role alkylating agents

and antimetabolites in treatment of cancer. Mention of carcinolytic antibiotics and mitotic inhibitors

Synthesis of merchlorethamine, cyclophosphamide, melphalan, uracil, mustard and 6-

mercaptopurine. Recent development in cancer chemotherapy.

Course Coordinator Dr. Ms. Ritu Yadav

M.Sc. Industrial Chemistry Semester III

ICH-C-327

Laboratory Course Compulsory to All Credits : 2 30 Hrs

1. Determination of Fe2+ in iron oreby K2Cr2O7(Heamatite,Magnetite) Pyrolusite.

2. Determination of avilavble lime or free CaO in industrial lime or in milk of lime iodometrically.

3. Determination of the amount of Blaching powder required to disinfecta water samleby Horock Test.

4. Determination of CMC of mied surfctant(Cation,Anion) by S.T. and conductivity.

5. To study the Kinetic of Degradation of Asprin at a given pH by titration method.

6. Spectrophotometric determination of Paracetamol in tablets.

7. Synthesis of dyes - Methyl orange from aniline ; Gosin from Pthalic anhydride

8. To determine the minimum dose of coagulate a given sampel by Jar Test.

9. Determination of total acid value ofan oil.

10. Detrminationof strong acid number of inorganic acidity of an oil.

11. To determine % of chlorine N Bleching powder.

12. Organic Synthesis and Spectral analysis of Synthesis of 7-hydroxy-4-methoxy coumarin; Phenl

formaldehyde resin ; Synthesis of soap ; Aldol condensation.

13. Estimation of - Nitrogen; Sulphur ; Methoxy group

14. Estimation of Keto-enol equillbrium.

15. To identify the amino acids by paper chromatography and determine ther Rf values.

Course Coordinator Dr Mrs. Ritu Yadav

24

ICH-E-328-4


Electro-chemistry

Credits : 2 30 Hrs

Condutometry: Study of relationship between ionic conductance and viscosity, measurement of conductivities of

electrolytes in mixed solvents.

II pH-metry: Titrations of polyprotic systems and Zwitter ions.

III Potentiometry: Acid-Base titrations in aqueous and non-aqueous media.

IV. Polarography: Determination of : (i). Vitamin C in fruit juices; (ii)Zn, Cd, Pb, Cu in samples of drinking

water ; (iii). Heavy metals in wood samples.

IV Amperometry: Amperometric titration of ; (i)Thiourea Vs Silver nitrate. (ii)Vitamin C Vs Ferric nitrate.

Note : Students must verify the results using statistical treatment :

V. Statistical treatment of data: Suitable experiments may be designed for statistical treatment of data: Standard

deviation, correlation coefficient, regression line, F-test, Q-test.

Course Coordinator Prof. Mrs. Archana Pandey

ICH-E-328-5


Analytical chemistry Credits : 2 30 Hrs Water analysis- : Determination of : Biological Oxygen Demand (B.O.D.); Chemical Oxygen Demand (C.O.D.) Dissolved

Oxygen (D.O.) ; Determination of Acidity / Alkalinity of water sample.

Separation and identification of organo – Chloro and Organo-phosphorous pesticides using Chromatography /

spectrophotometry :

Separation and identification of barbiturates from drug samples chromatography / spectrophotometry ;

Determination of viscosity and shear viscosity of polymer solution, microemulsion and gels by using

rheometer. Ion Selective Electrodes: Introductory idea about ionselective electrodes their fabrication: Co; Ni; Cu; Zn; Pd; Cd etc. and

determination of concentration of unknown of Co; Ni; Cu; Zn; Pd; Cd using prepared ion selective electrodes.

Course Coordinator Prof. S.N.Limaye


ICH-E-328-6

Medicinal- Chemistry

Credits : 2 30 Hrs Synthesis of following drugs.

Aspirin ; Paracetamol; Phenacetin ; Benzocaine ; Phenothiazine ; Isoniazide

Estimation of Cholesterol in blood sample by spectrophotometer.

Determination of λmax of paracetamol, Alprazolam, Ketoconazole, carbamazepam, hydrochlorothizide, theophyline,

compare with standard one.

Interpretation of IR Spectra of certain drugs and comparation with standard.

Analysis of ascorbic acid in given tablet by spectrophotometery.

Representative synthesis of drug molecules : ß-Binaphthol ; Ethyl (+)- (S)-3-hydroxybutyrate using Baker’s Yeast.


25

Dr. Hari Singh Gour Vishwavidyalaya, Sagar M.Sc. Industrial Chemistry

2013 - 14 SCHEME OF EXAMINATION

Semester IV


ICH-C-421 Industrial Polymer-II 03

ICH-C-422 Advanced Analytical Techniques 03

ICH-C-423 Drug Designing 03

ICH-E-424 Applied Electrochemistry – II 03

ICH-E-425 Environmental and Green Chemistry 03

ICH-E-426 Medicinal Chemistry – II 03

ICH-C-427 Laboratory Course I Common to all 02

ICH-E-4284 Laboratory Course – Electrochemistry 02

ICH-E-4285 Laboratory Course – Analytical Chemistry 02

ICH-E-4286 Laboratory Course – Medicinal Chemistry 02

26

M.Sc. Industrial Chemistry Semester IV

ICH-C-421

Industrial Polymers

Credits : 3 45 Hrs

1. Technique of polymerization, Bulk, solution, suspension, emulsion, melt, solvent solid and gas phase

polymerization.

8

2. Degradation of polymers; Oxidation, thermal, photo and hydrolytic degradation methods. 7

3. Commercial polymers: Industrial preparation of monomers for cellulose, rayon wool, polyester,

polyamide and acrylic fibres. Preparation modification, properties and uses of the fibres.

8

4. Commercial polymers-: Functional polymers: Electrically conducting polymers, fire retarding

polymers and Biomedical polymers.

7

5. Commercial polymers-: Plastics and resins: Preparation, properties of phenol- formaldehyde, urea-

formaldehyde, melamine- formaldehyde and glyptals. Epoxy resins and silicone polymers.

8

6. Structural Study-: Vibrational spectroscopy to study the crystallinity in synthetic polymers. Lamellar

thickness measurement by Raman methods.

7

Course Coordinator Prof. O.P.Chourasia

M.Sc. Chemistry semester IV; ICHE-E-422 :Advanced Analytical Chemistry

Credits : 3 45 Hrs

1. Basic theory and instrumentation Functional Elements of a Measuring System, Measuring

Instruments , Control Instruments,Calibration Instruments, Testing Instruments, Analytical

Instrument, Analog Instrument ,Digital Instrument, Transducer or sensors in Instruments. Some of the

important sensors along with their properties for Laboratory techniques and application : thermal

pressure, ion and gas sensing probes, micro-electrodes, optical spectrophotometers, ICP in AAS / AES.

Hyphenated techniques.

5

2. Thermo analytical methods, thermogravimetric analysis, Thermogravimetric analysis (TGA):

mass ; differential thermal analysis (DTA): temperature difference and differential scanning

calorimetry (DSC): heat difference ; Thermomechanical analysis (TMA): dimension ;

Dilatometry (DIL): volume ; Dynamic mechanical analysis (DMA) : mechanical stiffness &

damping ; Dielectric thermal analysis (DEA): dielectric permittivity & loss factor ; Evolved gas

analysis (EGA) : gaseous decomposition products ; Thermo-optical analysis(TOA) : optical

properties

10

3. Electro chemical methods, spctro electrochemistry. Modification of the electrodes for the

analytical applications and development of biosensors for the study of mechanism of drug

action and bio electrodes.

8

4. Chromatographic methods, Classification: Technique and Mechanism; paper and thin layer

chromatography adsorption, liquid liquid partition, ion exchange, HPTLC, DCC, gel permeation, and

gel electrophoresis and gas chromatography, HPLC.Columns and detectors in GC-HPLC -

Hyphenated techniques

10

5. Radio chemical methods, traces in chemical analysis, isotopic exchange, isotope dilution

analysis. NAA,

4

6. Optical microscopy: transmission electron microscope and scanning electron microscope.

Atomic force microscopy, electron and neutron scattering, osmometry, tensiometry,

ultrasonic absorption study

8

Course Coordinator Prof. S. N. Limaye

27


ICH-C-423

Drug Designing

Credits : 3 45 Hrs

1. Antibiotics : β-lactam rings, antibiotics inhibiting protein sybthesis. Synthesis of penicillin G, penicllin

V, amoxicillin, cephalosporin, tetracycline

5

2. Local Anti-infective Drugs

Introduction and general mode of action. Synthesis of sulphonamides,furazolidone, ciprofloxacin,

norfloxacin, dapsone, amino Salicylic acid, ethionamie, flucanazole, griseofulvin, chloroquin and

pramaquin.

10

3. Drug Design : Development of new drugs, procedures followed in drug design, concept of lead

compound and lead modification, concepts of prodrugs and softdrugs, structure- activity relationship

(SAR). Theories of drug activity: occupancy theory, rate theory, induced theory, Quantitative

structure activity relationship. History and development of QSAR. Concepts of drug receptors.

Elementary treatment of drug receptor interactions. physicochemical parameters: lipophilicity,

partition coefficient, electronic ionization constant, steric, Shelton and surface activity parameters

and redox potentials. Free-Wilson analysis, Hansch analysis, relationship between Free-Wilson and

Hansch analysis. LD-50, ED-50 (mathematical derivation of equations excluded).

15

4. Psychoactive Drug : Introduction, neurotransmitters, NA Dopamine, 5HT, acetylcholine, GABA,

Histamine, serotonin, CNS depressants, general anaesthetics, mode of action of hypnotics, sedatives,

anti-anxiety drugs, benzodiazipinene, neurochemistry of mental diseases. Antipsychotic drugs-

neurolcptics, antidepressants, butyrophenones.

Synthesis of diazepam, oxazepam, phenytoin, barbiturates, thiopental sodium, glutethimide.

15

Course Coordinator Prof. R.N.Yadav

28


ICH-C-424

Applied Electrochemistry

Credits : 3 45 Hrs

1. Electrodeposition:

Fectors affecting elctrodeposition of metals, Simultaneous discharge of cations, depolarisation of

metal deposition, separation of metals by electrolysis. Electrochemical passivity, Passivity and

current density, chemical passivity, theories of passivity, Mechanical passivity, Electroplating.

8

2. Corrosion:

The corrosion of metals: hydrogen evalution type and differential oxygenation type -corrosion.

Corrosion inhibition, Electrochemical theory of Corrosion

7

3. Bioelctrochemistry- Bioelectrodics:

Useful preliminaries biostructures (amino acids, proteins, DNA etc.) membrane potentials and

theories of membrane potentials. Enzyme as electrodes, electrochemical enzyme catalysed oxidation

of Styrene. William’s electrochemical model for metabolism. Electrochemical aspects of some bio-

processes. Electrochemical Biosensors.

8

4. Selected Aspects of Organic Electrochemistry:

General Introduction, determination of organoelectrochemical reactions: anodic oxidation of β-

Cynoethane, ethers. The manufacture of nylon.

7

5. Designer of Electrodes:

Introduction,formation of monolayers of organic molecules on electrodes. Different electrodes of

carbon as electrode material: Glassy corban electrode, carbon fibre electrode, carbon paste

electrode and carbon nano-tube paste based electrode and their applications

8

6. Newer Polarographic techniques: General treatment and applications the following techniques:

Anodic stripping voltammetry and cyclic voltammetry Chronopotentiometry Spectroelctrochemistry.

7

Course Coordinator Prof. Mrs. A. Pandey

29


ICH-C-425

Environmental and Green Chemistry

Credits : 3 45 Hrs

1. Green chemistry : Introduction to the green chemistry- prevention of waste, atom economy less

hazardous chemical synthesis, designing safer chemicals, safer solvents and auxallaries, design for

energy efficiency reduced derivatives, renewable feed stolks, catalysis, design for degradation, real

time analysis for pollution and prevention, inherently safer chemistry for accident prevention,

10

2. Green synthesis : clean routes, super critical solvents, ionic liquids, green catalyst, auto exhaust

catalyst and clean technology

5

3. Biotic and abiotic components of environments, macro environmental and micro environment by

cycles- C, O2, P, S, CO2 cycles bio-distribution of elements, chemical ‘speciation’

8

4. Pollution and its control, : atmospheric pollution gaseous air pollution, acid rain, particulate air

pollution, green house effect and ozone shield, radiation hazards,

4

5. Aquatic pollution- agricultural and pesticide pollutants, marine pollution, oil spills and oil pollution, 4

6. Industrial pollution - Soil pollution by oil industry, polymers, cement, fertilizers, paper and pulp,

mining and metallurgy textiles.

3

7. Environmental analytical chemistry : Techniques and quantification of pollutants: Trace elements

and radio nuclide analysis

4

8. Environmental Toxicology and detoxification mechanism : chemical solutions to environmental

problems, better bio degradability, kinetics of decomposition, soil remediation, chemical

remediation, bio remediation

7

Course Coordinator Prof. S.P.Shrivastava


ICH-C-426

Medicinal Chemistry

Credits : 3 45 Hrs

1. Drug acting on gastrointestinal disorder-treatment of peptic ulcers, emetics, antiemtics, drugs for

constipation and diarrhoea

10

2. Nopiod and opiod analgesics, non –steroidal anti- inflammatory drugs. Drugs used in arthritis.

Antagonists, chemotherapy of antimicrobial agents, Hematopoietic agents-growth factors,

minerals, anticoagulant, thrombolytic and anti-platelet drugs. Drug acting on skin and mucus

membranes

10

3. Urine examination- composition, sample collectiorarn, preservation, physical, chemical and

microscopic examination of urine, structure and formation of urine in kidney

5

4. Inflamation, regeneration and healing, vascular disorders- congestion, I ischemia, Hemorrhage,

thrombosis and infection, metabolic disorder- Jaundice, Biopsy and Autopy. Theory of fixation and

staining

10

5. Cardiovascular Drug

Introduction, cardiovascular diseases, drug inhibitors of peripheral sympathetic function, central

intervention of cardiovascular output, Direct acting article dialators.

Synthesis of amyl nitrate, sorbitrate, quinidine, verapmil, methyldopa, atenolol, oxyprenolol.

10

Course Coordinator Dr. Ratnesh das

30


ICH-C-427

Laboratory Course Compulsory to All Credits : 2 30 Hrs

Isolation of Caffeine from Tea leaves.

Isolation of Nicotine from Tobacco

Isolation of Limonene from Citrus rinds

Isolation of β- Carotene from Carrot

Isolation of Lycopene from tomatoes

Isolation of Lactose from Milk

Isolation of Casein from Milk

Isolation of Eugenol from cinnaman leaf oil or clove.

Isolation of Cucumarin from turmeric.

Isolation of oleo resin from ginger.

Isolation of cinchonine from cinchona bark.

Isolation of piperine from black pepper.

Isolation of oleic acid from olive oil (involving the preparation of complex with urea and separation of

linoleic acid).

Isolation of eugenol from cloves.

Extraction of fatty oil from Seed and determine the Density and refractive index of the oil

Isolation of Protein and Carbohydrate ( as reducing sugars) from Seeds - Color test

Estimation of SO4, CNS, PO4, Ag by nephelo / turbidi metry.

Estimation of aspirine, caffine, amino acids.

Estimation of carbohydrate, cholesterol by spectrophotometry.

Synthesis of some polymer and their rheological study

Molecular weight determination of high polymer, Miscellization of polymeric surfactants (PVP-44000, PG400,

PEG4000) by surface tension/viscosity or conductivity measurement methods.

To determine the structure of crystal by X-ray diffraction method

Course Coordinator Dr. Mrs. Ritu Yadav

31


ICH-E-428-4

Electrochemistry Credits : 2 30 Hrs

I Electrogravimetry: Determination of metals (single component), electroplating of metal ions.

II Polarography: Determination of

a. Fe and Mo in steel. b. Urea and glucose in biological fluids.

c. Heavy metals in wine samples and petroleum products.

III Amperometry: Amperometric titration of

a. Pb Vs SO42-

. b. Pb Vs K2Cr2O7. c. Ni Vs DMG.

IV Coulometry: Coulometric titration at constant current, Separation of metal ions by coulometric analysis at

controlled potential.

V. Study of metal chelates: Determination of overall and stepwise stability constant of metal chelates by

polarographic, pH-metric and conductometric techniques.

Note: Common for both III & IV Semester Laboratory work.

VI Statistical treatment of data: suitable experiments may be designed for statistical treatment of data:

Standard deviation, correlation coefficient, regression line, F-test, Q-test.

Course Coordinator Prof. Ratnesh das


ICH-C-428-5

Green Chemistry

Credits : 3 45 Hrs

Greener Synthesis : Acetylation of primary amine ; 4+2 Cycloaddition reaction, electrophilic aromatic substitution

reaction I, electrophilic aromatic substitution reaction II, green photochemical reactions, pinocole-pinacolone

rearrangement reaction I, radical coupling reaction, green oxidation reaction, three component coupling

reaction, synthesis of biodiesel, solvent free reaction, general environmental analysis.

Course Coordinator Dr. Mrs. Ritu Yadav


ICH-C-428-6

Medicinal Chemistry

Credits : 2 30 Hrs

Estimation : -OH (alcoholic and phenolic ), -OCH3, pri- sec- and tert- amine, amide, Estimation of

organic sulfur (by Messenger method), reducing sugars,

Synthesis and characterization of following drugs:

Benzanilide by Beckman rearrangement

N-(m-nitrobenzyl) aniline from m-nitrobenzaldehyde

1H-indole-3 carbaldehyde

2-phenyl indole

Cinnamic acid by Perkin reaction

ß-dimethylamines proplophenone hydrochloride (Manich Base)

Determination of the drug release by dissolution apparatus

To determine the kinetics of drug release by using different kinetic models Course Coordinator Dr. Ratnesh Das

dr. hari singh gour vishwavidyalaya, sagar - … · dr. hari singh gour vishwavidyalaya, sagar...

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