de jesusmb 1st environmental nanotechnology workshop · 2015-05-20 · title: microsoft word - de...
TRANSCRIPT
Nanotoxicology: Interactions between nanoparticles and cells
Marcelo Bispo de Jesus
Nano-‐Cell Interactions Lab., Biochemistry Department, Biology Institute, Campinas University, Campinas, SP, Brasil
Nanomaterials are released in the atmosphere from natural events (e.g. volcano eruption) even before life started on Earth. Recently, the advances in material manipulation increased the variety and the amount of these nanomaterials into the atmosphere. Eventually, these nanomaterials will interact with animals, including humans, and regarding their nano scale properties; they will reach the cellular environment. Eukaryotic cells, via endocytosis, can internalize nanomaterials and inside the cells they can trigger different cellular responses (cell-‐cycle and proliferation irregularities, inflammatory cytokine production, diminution in mitochondrial function, activation of cell signaling pathways, autophagy, apoptosis, and cell death). Understanding the molecular interaction of nanomaterials in the context of the cellular environment is crucial for the success of nanomaterials. In this seminar we will discuss the nanotoxicology at molecular level. Briefly, we will talk about the major endocytic pathways; by which cell can internalize nanomaterials. In addition, we will discuss the intracellular trafficking, metabolism, and undesirable effects of nanomaterials in eukaryotic cells.