d - chiba uopac.ll.chiba-u.jp/da/curator/900112992/kj00005668294.pdfvitamin b complex and liver...
TRANSCRIPT
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -59-
Vitamin B Complex and Liver Function in Skin Diseases
Dφ artment 01 DermatologySchool 01 MedicineChibα University
KATSU TAKENOUCHI乱 1D
KAZUO ASO乱 1D
SHO]I OKAMOTO
Ko UTSUMIM D
( DirectoγPγof K Tαkeγzouchi)
( Recei匂 ed10γ争 ublicαtionMt的 10 1962)
We think that disturbed vitamins metabolism and disturbed liver functions are significant
as ari endogenous cause of some skin diseases We wish to discuss the results of in咽
vestigations carried out in our clinic which support our views on this point
Clinically deficiency in vitamins is apt to cause dermatoses lactic acid tends to
accumulate in the skinwhere oxygen consumption is lower than in any other organand
glycolysis is comparatively active So we think that TCA cyc1e tends to become abnormal
causing disturbance in vitamins metabolism in skin diseasesas shown in Figl amp Tab 1
Therefore special attention should be paid to vitaminsespecially vitamin Bcomplex
QN2 口 115
L
2 1副 a咋回ga旬w1eC司waguemn也 taete QOz 口 06
darrS旬 -rat-QZ L
cerebral cortex of mouse
liver of mouse
skin of mouse 口 08
口15skin of man
Fig 1 Glycolysis and Respiration of the Skin
Fig 1 shows schema of TCA cyc1e at left side and carbon-dioxide
formation (glycolysis) and oxygen consumption of the skin at
right side Experiments show that oxygen consumption of the
skin is less compared with other organswhi1e carbon-dioxide
formation is relatively high These data means that TCA
cyc1e activity is relatively low in the skin
Tab 1 Amount of glycogenlactatecitrateα-keto-glutaratethiamineand
riboflavin in the skin and other tissues
tissue
skin
cerebral cortex
liver 28
300
350
(Tab1showshiUMla山 ac山 theskin compared wi山 hhellipgan) This finding also show that TCA cyc1e in the skin is low J
Vitamin B Complex and Liver Function in Skin Diseases -60- 38巻第
which concerned in TCA cycle as shown in Fig 2 Fig 3 shows the amounts of are
thiamine riboflavin and lipoic acid in the skin estimated in our clinic
We assumed that vitamin B-complex would play one of the important role in some skin
diseases This assumption has been validated by the results of tests for metabolism of
thiamine riboavinand pyridoxine carried out in various skin diseases 自
Tab 2 shows the results of tests for thiamine metabolism carried out in 560 cases of
仏 ゥ00 日
モ ノ 目
斗い
刀
thiamine 06~07 riboflavin 05~09 ( epidermis)
uanvt
t5ns
Q
U
J
4
i
da--I
JHugb
F
mI
aηm
thiamine lipoic acid pantothenic acid
は
山
叫叫ん肌
trL
tiEb
Fig 3 Amount of Thiamine Riboflavin Vitamin B6 and Lipic acid in the Skin μgjg
IMamm06~10μghellipmethod) riboflavin 05~08μg (lumi丑 avinmethod) I pyridoxine 107μg (bioassay method) I lipoic Acid 005~015μg (bioassay method) J
Fig 2 Vitamin B Complex in Glycolysis
and Respiration
Tab 2 Thiamine Metabolism in Various Diseases of the Skin (Diseases in which a sufficiently large number of patents were examined)
normal Man 5
0
5
つ ムワ
Cases examined Normal Suboptimal Deficient
h
q
25
urticaria Group 19 1 0
dermatitis 50 14 11
はじUL~ tじ乙tIlla
chronic eczema
infant eczema
eczema
(t
78
43
193 128 41 24
lupus eryth (S L E)
discoid e
3
5
2
5 1 psonasls
herpes zoster
pellagra
ari boflavinosis
Stryker amp Halbeisen syndrome
cheilitis amp angstomatitis
alopecia areata
nevus plg
vitiligo
15
9
4
9
3
16
31
5
38
11 3
6 2
1 1
2 3
15
22 4
5
25 8
1
1
2
4
3
1
5 5
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -61-
Tab 3 Thiamine Metabolism in Eczema
h
x
a
-
--~I
l
n
u
4
a
-
h
v
H
l
M
t
m
m
tzebfkμ-
5
p
d
)
GIllie-ill--
出
一
ueovgU
eiad
μ
Q
J
M
手
d
a
Mmn
mmmu
d aJ1111111l 一
内
Vlaa
刷
白
日u
泊目一 0
0
0
0
0
0
4
mnu3
LM
m
明釦山
恥
四
士
一
fγ
一
1
0
0
0
1
0
6
1〆
L
一
t
uarr一j一一 amp
1
E
a
a
d
q
δ
A
】ノ
凶
肱
Lふ
工
五一 つ
い
e-mdvr)U一
mnloee恒一
1
0
4
5
6
N
引
一
う Noof
d
ae
amp
m
cases 閣岨
t
c
m
m光市一
m
勘広間凶一
Fexam-
1
l
a
g
3
mm
mmοk
出回
批 ined 白
i
一3
0
0
0
3
0
5
3
3
2
一
b
Illi---Illi--lolli--
0
1
8
川
崎
一
回
但
冗
加
礼
節
風
1
一一 一 一 一一一llilia---llili--Ili
一
2
3
4
2
2
2
9
1 eczema capiliti
2 eczema follicularis
3 eczema mammae
4 blepharitis eczematosa
生
ワ
ム
q
ο
q
b
n
u
5 eczema sycosiforme
6 eczema periorale qJ7 other acute and subacute
eczema
n
J
1
dっ ロUFhdnU
にU
q
h
F
h
d
A吐
品
ム
噌
dA
2
噌 E
E
4
0
5
7
5
2
2
2
0
ム
唱
ム
守
5 I
47 421
59 510
60 466
83 609i
1 62 597
86 86
48 485
475
7 I 12
1
1 I 1
可
4
司 i
A
U
A
8 eczema of exposed area
9 eczema and et vulvae
10 atopic eczema
11 neurodermatitis circumscripta 2 I 1
1 I 0
010
3 I 0
2 I 0
リ
氏
5
3
5
3
1
6
5
2
u
n
υ
n
u
n
U
Q
U
12 lichen simplex chronicus
13 dermatitis papi11aris capiliti
14 nummular eczema
15 seborrheic dermatitis
61 59416 other chronic eczema 2 I 2 ムE
Tab 4 Comparison of Clinical and Labolatory Findings of
Dermatitis of Exposed Area with Pellagra
ム
合e58y d合e50y d合e45y
x of ti tis ofltitis of titis of titis of titis of
d 昔e前 e50y e 67y|ld y||d合 72y 47y ma-I aerma-I aerma-der5m7ay-』 d合er7m5ay dr立 la- rma- rma-
titeis x-of tlteis x-of titeis pel- I pel- ex- ex- ex- ex- ex-lagra Ilagra posed I posed I posed posed I posed posed posed posed
area I area I area areaarea I area area area
267
66 58 I 68
12 10 1131
288 301
60 60
091 10
789
(一〉 (十〉|()
(十) (土) (十〉
(十件) (叶) I (1ft)
KSD (一〉 KSD
(十) (一〉
(十〉
(ー〉
(+)(十〉
(~)(+)(十件)
(-)(-) (+)
count of erythro-cytes
hemoglobin
colour index
mean diameter of erythrocyte
free Hcl
liver dysfunction
thiamine meta-bolism
oapnhdtihnag lmological
knee jerk reflex
chei1itisstoma-titis
diarrhoea
o bsti pa tion
785 I 795
(-)
(+)
(+十〉
KSD
(-)
(+)
(-)
(土)
(-)
(+)
(+十)
(-)
(一)
(十十〉
(-)
(+)
330
70
105
79
(一)
(1ft)
(+ト)
(ー)
(一)
(十)
(-)
(-)
315 350 293 350
68 76 70 68
10108 12 0971
797 790787 786
(+) (一) (一〉
(-)(十) (土)(士〉
(廿十) ( 1ft ) (+十) (+十〉
KSD cIniljieacl tlon ciniljieacl tion c1nilIiEaC1 tIon
(+) (一〉 (土)(一〉
(+) (ー) (一) (一)
(ー) (-)(一〉 (一〉
(~)(土) (十〉 (土)
-62- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
asthenic feeling
ultra~violet-ray test
parasitism
serum protein
(+)
(-)
(十十〉
(一)
(+)
(一)
(一)
78
(-) (-)
(-) (一) I(一) I(一) (一〉 (-) (-)
(一) I (一 )ascans ascans(一) (-) (-)
638606(+8〉 |6(+4) 73 69 78
=Keratitis superficials diffusa
(m 4Sh仰附吋helliphellip ws吋巾叫ttha 討im凶凶山山山helliph伽刷a訂凶打吋一KSD
抗t helliphellipS油山山helliphellip加伽凶hellips出山脳 加凶凶叫山山江愉凶O叩一hellip iri凶a la
body and pellagra in c1inical f自indingfor instance disturbed liver functionanacidity I in gastric juiceand ophthalmological五ndings )
various skin diseases It will be seen that no small number of patients beginning with
patients with eczemaare attended by disturbed thiamine metabolism We wish to call
your attention to the fact thatas shown in Tab 3 metabolic insu伍 ciencyof thiamine
was seen more commonly in patients with eczema who have the lesions in the exposed
part of the skin It is also of interest that the findings of gastric juiceeye and blood in
inany of these patients were near1y the same as the findings in patients with pellagra as
shown in Tab 4
Tab 5 gives the results of tests for blood pyruvate levels in 87 patients Tab 6 shows
Tab 5 Blood Level of Pyruvate in Eczema and Dermatitis
Noof icnaesdDiseases es INormall Suboptimal Abnormal exam
toi1et dermatitjs
contact dermatitis
dermatitis of exposed area
eczeme ani et vulvae
eczema tyloticum rhagadiforme
eczeme mamrnae
eczerna capiliti
other acute or chronic eczema
eczerna of exposed area
chronic eczema
7
13
4
4
3
2
2
18
13
21
5
7 2
2
2
2
12
2
10
1
1
24 3
1
5
2
2
1 2
11
8
[TO山 7 j(5払 11 32 (12) (38)
Tab 6 Blood Level of Riboflavin in Various Diseases of the Skin (Average)μgdl
同二ょzzs|totaldbona叫 es附 ribo白川 rateof e町
norrnal rnen 9485
acute eczema 8711
chronic eczema 8275
dermatitis 8421
seborrheic dermatitis 8689
erythroderma 9030
erytherna multiforme 8521
So called ariboflavinosis 7548
ariboflavinosis 7271
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -63-
the results of tests for riboflavin levels and their relation to skin diseases in 317 patients
and Tab 7 gives the results of similar tests on pyrodoxine It is strange there should be
no disturbance of pyridoxine metabolism in the so-called seborrheic dermatitis
The results of experiments shown so far indicate that there is a disturbance of meta-
bolism of vitamin B-complex in a large proportion of patients with eczema dermatitis
erythroderma lupus erythematodes disseminatus and psoriasis In fact adminiatration of
vitamin Bcomplex has had effects in these patients In Tab 8--9 are listed the skin 同
diseases in which vitamins may be used with some effects
Tab 7 Metabolism of Vitamin B6 in Various Diseases of the Skin (Results
of Load Test of Vitamin B6)
DiseasesNormal Suboptimal Defici削
4
2
5
3
eczema 2
dermatitis 12 seborrheic dermatitis
2 erythroderm ia 4
psonasls 12 d
τ
i
T
i
urticaria
erytheina todes 11 muco cutaneoussyndrome
2 1
erythema nodosum
acne vulgaris 1 1
skin carcinoma 11 Pegets disease 1 leucamia cutis
neurosyphilis 1
chei1itis 1
drug eruption 1
spontaneous gangrane 1
hysterical gangrane 1
Total 22 13 13
Tab 8 Derinal Manifestation Vttamins Deficiency and their
application to Skin Diseases
つ
Vitamin Animal
rabbit depilation as alopecia areata
thiamile mouse roughness of the hair
h川町 mati出 depilation
pig dermatitis
riboflavin
Human Indicat面白 of Skin
Diseases
paleness of the skin allergic dermatoses pellagra
disa ppearance of alopecia areata herpes skin-elasticity (Elson) zoster psoriasis vulgaris
seborrhoeic dermatitis on 1 ariboflavinosis pellagra the nasolabial folds yen sunlight Dermatitis eyelid and ear1aps 1 facial desquamative cheilitisstomatitis eczema rosacea sycosis angularis (Sebrel amp 1 vulgaris eczema Butler) scrotal derma- infantiledermatitis 1 titis erythematous 1 seborrhoeic eczema
ldqumtinnthhdl b hidmtiti of the elbow acne like acne vulgaris1
lesion (Nakagawa Yasu
da) glossitis (Kruse Jollife)
-64- Vitamin B Complex and LiveI Function in Skin Diseases 第 38巻
a Ipellagra
3
m
HU
JA
一
白
》一
即
日
一
剖ヨ
一
一 一一一
一
直一一一
刀
副
一一一 一 一 一一副
一
ザ
日
目
陥
一
件
山
中
pellagraerythematodesd
pg
Lm
m
dE
T
n
U 1
1
e
l
a
e
-
-
e
g
g
m
SO
d
m
-
h
u
V
l
i
o
c|
|
e
r
山
田
加
は
出
田
立
コ
xeroderma pigmentosum rosaceasunlight
dhellip| chronic urticaria
ipb
i出 pernio戸阿阿訂的
strophtllus infantum
seborrhoeic dermatitis m E
A
B
cheilitis stomatitis
北
孔
amp
infantile seborrheic glossitis dermatitisacne vulgaris
田βhsod
m
w
u
cmu
z
e
a
n
ummagm
引
げ
口
口
dmぼ珂比
配川
infinlmT
ndpd
抗
町
民
出幻
qu
pellagra-like dermatitis allergic derniatoses (caused by Muller-V ilter by the use of desoxypyridoxine)
M
h
a
p
a
o
t
-
- 一 eηy訂 r凶r円humO
spaba
PC m
Um
tι
白」
imouse emhematous idryness of the skin-(e巾 hrodermiaexfoliativa idesquamative dermatitisI pityriasislike desquama-I (Leiner)
itamin H rat depigmentation tive de~-ati~ ~n t~ ~eor7~eic dermatitis
此凶丸山
ethii~tJtn) I ~~e~~~~~~~S_~~~stric- ~~~a__n山 eαemaIker)desquamative Iacne vulgari dermatitis of exposed
area (Williams)
出
副日九川
IpoliosiserythematodesZ52立おI ion d~~~~出s herpetiformisrat de仰向凶
Duhring
inositolrat atrichosis
listryke叶 lalbeisenfolic acid Irat depigmentation Isyndrome
hn 同 poliosisalopecia江
I
DA L 創ゐ psoriasis vulgaris唄1
d 唱
し
Tab9
日 剖 内
口
旧いに副
ほ
ddH
a-u
+Lt
e
mMne
QU
eneb唱
胃
げ
eaQUS
vzykFn
trF
hEKI
epenu
EA4Eb
C
F
GV
vitamin Bロ
江
I配sC問 eydryness of the I~戸igmenvitamin c | S kinMic伽allergic dermatoses
keratose (Crandon)
follicular keratose Ikeratose Vitamin A Iryness o~ the ~10n follic山 rkeratoseI
Ihyposecretion of Sweet Iichytyosis (FrazierFu) Ikeratosis follicularis
(T ab helliphellipmωnhellipih凶凶耐fe百
the left cornerand skin lesion caused by Vitamin B complex in man in the midle I At the right corner dermatoses in which B complex may have some effects are listed)
The relation between liver function and skin diseases has attracted the attention of
various investigators Disturbed liver function tends to lead to disturbed metabolism of
vitamins Sothe relation between the two cannot be overlooked
Tob 10-11 show the relation of thiamine and ribo自avinto liver function It will be
seen that liver function is related to metabolic disturbence of thiamine and ribofiavin
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
Vitamin B Complex and Liver Function in Skin Diseases -60- 38巻第
which concerned in TCA cycle as shown in Fig 2 Fig 3 shows the amounts of are
thiamine riboflavin and lipoic acid in the skin estimated in our clinic
We assumed that vitamin B-complex would play one of the important role in some skin
diseases This assumption has been validated by the results of tests for metabolism of
thiamine riboavinand pyridoxine carried out in various skin diseases 自
Tab 2 shows the results of tests for thiamine metabolism carried out in 560 cases of
仏 ゥ00 日
モ ノ 目
斗い
刀
thiamine 06~07 riboflavin 05~09 ( epidermis)
uanvt
t5ns
Q
U
J
4
i
da--I
JHugb
F
mI
aηm
thiamine lipoic acid pantothenic acid
は
山
叫叫ん肌
trL
tiEb
Fig 3 Amount of Thiamine Riboflavin Vitamin B6 and Lipic acid in the Skin μgjg
IMamm06~10μghellipmethod) riboflavin 05~08μg (lumi丑 avinmethod) I pyridoxine 107μg (bioassay method) I lipoic Acid 005~015μg (bioassay method) J
Fig 2 Vitamin B Complex in Glycolysis
and Respiration
Tab 2 Thiamine Metabolism in Various Diseases of the Skin (Diseases in which a sufficiently large number of patents were examined)
normal Man 5
0
5
つ ムワ
Cases examined Normal Suboptimal Deficient
h
q
25
urticaria Group 19 1 0
dermatitis 50 14 11
はじUL~ tじ乙tIlla
chronic eczema
infant eczema
eczema
(t
78
43
193 128 41 24
lupus eryth (S L E)
discoid e
3
5
2
5 1 psonasls
herpes zoster
pellagra
ari boflavinosis
Stryker amp Halbeisen syndrome
cheilitis amp angstomatitis
alopecia areata
nevus plg
vitiligo
15
9
4
9
3
16
31
5
38
11 3
6 2
1 1
2 3
15
22 4
5
25 8
1
1
2
4
3
1
5 5
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -61-
Tab 3 Thiamine Metabolism in Eczema
h
x
a
-
--~I
l
n
u
4
a
-
h
v
H
l
M
t
m
m
tzebfkμ-
5
p
d
)
GIllie-ill--
出
一
ueovgU
eiad
μ
Q
J
M
手
d
a
Mmn
mmmu
d aJ1111111l 一
内
Vlaa
刷
白
日u
泊目一 0
0
0
0
0
0
4
mnu3
LM
m
明釦山
恥
四
士
一
fγ
一
1
0
0
0
1
0
6
1〆
L
一
t
uarr一j一一 amp
1
E
a
a
d
q
δ
A
】ノ
凶
肱
Lふ
工
五一 つ
い
e-mdvr)U一
mnloee恒一
1
0
4
5
6
N
引
一
う Noof
d
ae
amp
m
cases 閣岨
t
c
m
m光市一
m
勘広間凶一
Fexam-
1
l
a
g
3
mm
mmοk
出回
批 ined 白
i
一3
0
0
0
3
0
5
3
3
2
一
b
Illi---Illi--lolli--
0
1
8
川
崎
一
回
但
冗
加
礼
節
風
1
一一 一 一 一一一llilia---llili--Ili
一
2
3
4
2
2
2
9
1 eczema capiliti
2 eczema follicularis
3 eczema mammae
4 blepharitis eczematosa
生
ワ
ム
q
ο
q
b
n
u
5 eczema sycosiforme
6 eczema periorale qJ7 other acute and subacute
eczema
n
J
1
dっ ロUFhdnU
にU
q
h
F
h
d
A吐
品
ム
噌
dA
2
噌 E
E
4
0
5
7
5
2
2
2
0
ム
唱
ム
守
5 I
47 421
59 510
60 466
83 609i
1 62 597
86 86
48 485
475
7 I 12
1
1 I 1
可
4
司 i
A
U
A
8 eczema of exposed area
9 eczema and et vulvae
10 atopic eczema
11 neurodermatitis circumscripta 2 I 1
1 I 0
010
3 I 0
2 I 0
リ
氏
5
3
5
3
1
6
5
2
u
n
υ
n
u
n
U
Q
U
12 lichen simplex chronicus
13 dermatitis papi11aris capiliti
14 nummular eczema
15 seborrheic dermatitis
61 59416 other chronic eczema 2 I 2 ムE
Tab 4 Comparison of Clinical and Labolatory Findings of
Dermatitis of Exposed Area with Pellagra
ム
合e58y d合e50y d合e45y
x of ti tis ofltitis of titis of titis of titis of
d 昔e前 e50y e 67y|ld y||d合 72y 47y ma-I aerma-I aerma-der5m7ay-』 d合er7m5ay dr立 la- rma- rma-
titeis x-of tlteis x-of titeis pel- I pel- ex- ex- ex- ex- ex-lagra Ilagra posed I posed I posed posed I posed posed posed posed
area I area I area areaarea I area area area
267
66 58 I 68
12 10 1131
288 301
60 60
091 10
789
(一〉 (十〉|()
(十) (土) (十〉
(十件) (叶) I (1ft)
KSD (一〉 KSD
(十) (一〉
(十〉
(ー〉
(+)(十〉
(~)(+)(十件)
(-)(-) (+)
count of erythro-cytes
hemoglobin
colour index
mean diameter of erythrocyte
free Hcl
liver dysfunction
thiamine meta-bolism
oapnhdtihnag lmological
knee jerk reflex
chei1itisstoma-titis
diarrhoea
o bsti pa tion
785 I 795
(-)
(+)
(+十〉
KSD
(-)
(+)
(-)
(土)
(-)
(+)
(+十)
(-)
(一)
(十十〉
(-)
(+)
330
70
105
79
(一)
(1ft)
(+ト)
(ー)
(一)
(十)
(-)
(-)
315 350 293 350
68 76 70 68
10108 12 0971
797 790787 786
(+) (一) (一〉
(-)(十) (土)(士〉
(廿十) ( 1ft ) (+十) (+十〉
KSD cIniljieacl tlon ciniljieacl tion c1nilIiEaC1 tIon
(+) (一〉 (土)(一〉
(+) (ー) (一) (一)
(ー) (-)(一〉 (一〉
(~)(土) (十〉 (土)
-62- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
asthenic feeling
ultra~violet-ray test
parasitism
serum protein
(+)
(-)
(十十〉
(一)
(+)
(一)
(一)
78
(-) (-)
(-) (一) I(一) I(一) (一〉 (-) (-)
(一) I (一 )ascans ascans(一) (-) (-)
638606(+8〉 |6(+4) 73 69 78
=Keratitis superficials diffusa
(m 4Sh仰附吋helliphellip ws吋巾叫ttha 討im凶凶山山山helliph伽刷a訂凶打吋一KSD
抗t helliphellipS油山山helliphellip加伽凶hellips出山脳 加凶凶叫山山江愉凶O叩一hellip iri凶a la
body and pellagra in c1inical f自indingfor instance disturbed liver functionanacidity I in gastric juiceand ophthalmological五ndings )
various skin diseases It will be seen that no small number of patients beginning with
patients with eczemaare attended by disturbed thiamine metabolism We wish to call
your attention to the fact thatas shown in Tab 3 metabolic insu伍 ciencyof thiamine
was seen more commonly in patients with eczema who have the lesions in the exposed
part of the skin It is also of interest that the findings of gastric juiceeye and blood in
inany of these patients were near1y the same as the findings in patients with pellagra as
shown in Tab 4
Tab 5 gives the results of tests for blood pyruvate levels in 87 patients Tab 6 shows
Tab 5 Blood Level of Pyruvate in Eczema and Dermatitis
Noof icnaesdDiseases es INormall Suboptimal Abnormal exam
toi1et dermatitjs
contact dermatitis
dermatitis of exposed area
eczeme ani et vulvae
eczema tyloticum rhagadiforme
eczeme mamrnae
eczerna capiliti
other acute or chronic eczema
eczerna of exposed area
chronic eczema
7
13
4
4
3
2
2
18
13
21
5
7 2
2
2
2
12
2
10
1
1
24 3
1
5
2
2
1 2
11
8
[TO山 7 j(5払 11 32 (12) (38)
Tab 6 Blood Level of Riboflavin in Various Diseases of the Skin (Average)μgdl
同二ょzzs|totaldbona叫 es附 ribo白川 rateof e町
norrnal rnen 9485
acute eczema 8711
chronic eczema 8275
dermatitis 8421
seborrheic dermatitis 8689
erythroderma 9030
erytherna multiforme 8521
So called ariboflavinosis 7548
ariboflavinosis 7271
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -63-
the results of tests for riboflavin levels and their relation to skin diseases in 317 patients
and Tab 7 gives the results of similar tests on pyrodoxine It is strange there should be
no disturbance of pyridoxine metabolism in the so-called seborrheic dermatitis
The results of experiments shown so far indicate that there is a disturbance of meta-
bolism of vitamin B-complex in a large proportion of patients with eczema dermatitis
erythroderma lupus erythematodes disseminatus and psoriasis In fact adminiatration of
vitamin Bcomplex has had effects in these patients In Tab 8--9 are listed the skin 同
diseases in which vitamins may be used with some effects
Tab 7 Metabolism of Vitamin B6 in Various Diseases of the Skin (Results
of Load Test of Vitamin B6)
DiseasesNormal Suboptimal Defici削
4
2
5
3
eczema 2
dermatitis 12 seborrheic dermatitis
2 erythroderm ia 4
psonasls 12 d
τ
i
T
i
urticaria
erytheina todes 11 muco cutaneoussyndrome
2 1
erythema nodosum
acne vulgaris 1 1
skin carcinoma 11 Pegets disease 1 leucamia cutis
neurosyphilis 1
chei1itis 1
drug eruption 1
spontaneous gangrane 1
hysterical gangrane 1
Total 22 13 13
Tab 8 Derinal Manifestation Vttamins Deficiency and their
application to Skin Diseases
つ
Vitamin Animal
rabbit depilation as alopecia areata
thiamile mouse roughness of the hair
h川町 mati出 depilation
pig dermatitis
riboflavin
Human Indicat面白 of Skin
Diseases
paleness of the skin allergic dermatoses pellagra
disa ppearance of alopecia areata herpes skin-elasticity (Elson) zoster psoriasis vulgaris
seborrhoeic dermatitis on 1 ariboflavinosis pellagra the nasolabial folds yen sunlight Dermatitis eyelid and ear1aps 1 facial desquamative cheilitisstomatitis eczema rosacea sycosis angularis (Sebrel amp 1 vulgaris eczema Butler) scrotal derma- infantiledermatitis 1 titis erythematous 1 seborrhoeic eczema
ldqumtinnthhdl b hidmtiti of the elbow acne like acne vulgaris1
lesion (Nakagawa Yasu
da) glossitis (Kruse Jollife)
-64- Vitamin B Complex and LiveI Function in Skin Diseases 第 38巻
a Ipellagra
3
m
HU
JA
一
白
》一
即
日
一
剖ヨ
一
一 一一一
一
直一一一
刀
副
一一一 一 一 一一副
一
ザ
日
目
陥
一
件
山
中
pellagraerythematodesd
pg
Lm
m
dE
T
n
U 1
1
e
l
a
e
-
-
e
g
g
m
SO
d
m
-
h
u
V
l
i
o
c|
|
e
r
山
田
加
は
出
田
立
コ
xeroderma pigmentosum rosaceasunlight
dhellip| chronic urticaria
ipb
i出 pernio戸阿阿訂的
strophtllus infantum
seborrhoeic dermatitis m E
A
B
cheilitis stomatitis
北
孔
amp
infantile seborrheic glossitis dermatitisacne vulgaris
田βhsod
m
w
u
cmu
z
e
a
n
ummagm
引
げ
口
口
dmぼ珂比
配川
infinlmT
ndpd
抗
町
民
出幻
qu
pellagra-like dermatitis allergic derniatoses (caused by Muller-V ilter by the use of desoxypyridoxine)
M
h
a
p
a
o
t
-
- 一 eηy訂 r凶r円humO
spaba
PC m
Um
tι
白」
imouse emhematous idryness of the skin-(e巾 hrodermiaexfoliativa idesquamative dermatitisI pityriasislike desquama-I (Leiner)
itamin H rat depigmentation tive de~-ati~ ~n t~ ~eor7~eic dermatitis
此凶丸山
ethii~tJtn) I ~~e~~~~~~~S_~~~stric- ~~~a__n山 eαemaIker)desquamative Iacne vulgari dermatitis of exposed
area (Williams)
出
副日九川
IpoliosiserythematodesZ52立おI ion d~~~~出s herpetiformisrat de仰向凶
Duhring
inositolrat atrichosis
listryke叶 lalbeisenfolic acid Irat depigmentation Isyndrome
hn 同 poliosisalopecia江
I
DA L 創ゐ psoriasis vulgaris唄1
d 唱
し
Tab9
日 剖 内
口
旧いに副
ほ
ddH
a-u
+Lt
e
mMne
QU
eneb唱
胃
げ
eaQUS
vzykFn
trF
hEKI
epenu
EA4Eb
C
F
GV
vitamin Bロ
江
I配sC問 eydryness of the I~戸igmenvitamin c | S kinMic伽allergic dermatoses
keratose (Crandon)
follicular keratose Ikeratose Vitamin A Iryness o~ the ~10n follic山 rkeratoseI
Ihyposecretion of Sweet Iichytyosis (FrazierFu) Ikeratosis follicularis
(T ab helliphellipmωnhellipih凶凶耐fe百
the left cornerand skin lesion caused by Vitamin B complex in man in the midle I At the right corner dermatoses in which B complex may have some effects are listed)
The relation between liver function and skin diseases has attracted the attention of
various investigators Disturbed liver function tends to lead to disturbed metabolism of
vitamins Sothe relation between the two cannot be overlooked
Tob 10-11 show the relation of thiamine and ribo自avinto liver function It will be
seen that liver function is related to metabolic disturbence of thiamine and ribofiavin
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -61-
Tab 3 Thiamine Metabolism in Eczema
h
x
a
-
--~I
l
n
u
4
a
-
h
v
H
l
M
t
m
m
tzebfkμ-
5
p
d
)
GIllie-ill--
出
一
ueovgU
eiad
μ
Q
J
M
手
d
a
Mmn
mmmu
d aJ1111111l 一
内
Vlaa
刷
白
日u
泊目一 0
0
0
0
0
0
4
mnu3
LM
m
明釦山
恥
四
士
一
fγ
一
1
0
0
0
1
0
6
1〆
L
一
t
uarr一j一一 amp
1
E
a
a
d
q
δ
A
】ノ
凶
肱
Lふ
工
五一 つ
い
e-mdvr)U一
mnloee恒一
1
0
4
5
6
N
引
一
う Noof
d
ae
amp
m
cases 閣岨
t
c
m
m光市一
m
勘広間凶一
Fexam-
1
l
a
g
3
mm
mmοk
出回
批 ined 白
i
一3
0
0
0
3
0
5
3
3
2
一
b
Illi---Illi--lolli--
0
1
8
川
崎
一
回
但
冗
加
礼
節
風
1
一一 一 一 一一一llilia---llili--Ili
一
2
3
4
2
2
2
9
1 eczema capiliti
2 eczema follicularis
3 eczema mammae
4 blepharitis eczematosa
生
ワ
ム
q
ο
q
b
n
u
5 eczema sycosiforme
6 eczema periorale qJ7 other acute and subacute
eczema
n
J
1
dっ ロUFhdnU
にU
q
h
F
h
d
A吐
品
ム
噌
dA
2
噌 E
E
4
0
5
7
5
2
2
2
0
ム
唱
ム
守
5 I
47 421
59 510
60 466
83 609i
1 62 597
86 86
48 485
475
7 I 12
1
1 I 1
可
4
司 i
A
U
A
8 eczema of exposed area
9 eczema and et vulvae
10 atopic eczema
11 neurodermatitis circumscripta 2 I 1
1 I 0
010
3 I 0
2 I 0
リ
氏
5
3
5
3
1
6
5
2
u
n
υ
n
u
n
U
Q
U
12 lichen simplex chronicus
13 dermatitis papi11aris capiliti
14 nummular eczema
15 seborrheic dermatitis
61 59416 other chronic eczema 2 I 2 ムE
Tab 4 Comparison of Clinical and Labolatory Findings of
Dermatitis of Exposed Area with Pellagra
ム
合e58y d合e50y d合e45y
x of ti tis ofltitis of titis of titis of titis of
d 昔e前 e50y e 67y|ld y||d合 72y 47y ma-I aerma-I aerma-der5m7ay-』 d合er7m5ay dr立 la- rma- rma-
titeis x-of tlteis x-of titeis pel- I pel- ex- ex- ex- ex- ex-lagra Ilagra posed I posed I posed posed I posed posed posed posed
area I area I area areaarea I area area area
267
66 58 I 68
12 10 1131
288 301
60 60
091 10
789
(一〉 (十〉|()
(十) (土) (十〉
(十件) (叶) I (1ft)
KSD (一〉 KSD
(十) (一〉
(十〉
(ー〉
(+)(十〉
(~)(+)(十件)
(-)(-) (+)
count of erythro-cytes
hemoglobin
colour index
mean diameter of erythrocyte
free Hcl
liver dysfunction
thiamine meta-bolism
oapnhdtihnag lmological
knee jerk reflex
chei1itisstoma-titis
diarrhoea
o bsti pa tion
785 I 795
(-)
(+)
(+十〉
KSD
(-)
(+)
(-)
(土)
(-)
(+)
(+十)
(-)
(一)
(十十〉
(-)
(+)
330
70
105
79
(一)
(1ft)
(+ト)
(ー)
(一)
(十)
(-)
(-)
315 350 293 350
68 76 70 68
10108 12 0971
797 790787 786
(+) (一) (一〉
(-)(十) (土)(士〉
(廿十) ( 1ft ) (+十) (+十〉
KSD cIniljieacl tlon ciniljieacl tion c1nilIiEaC1 tIon
(+) (一〉 (土)(一〉
(+) (ー) (一) (一)
(ー) (-)(一〉 (一〉
(~)(土) (十〉 (土)
-62- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
asthenic feeling
ultra~violet-ray test
parasitism
serum protein
(+)
(-)
(十十〉
(一)
(+)
(一)
(一)
78
(-) (-)
(-) (一) I(一) I(一) (一〉 (-) (-)
(一) I (一 )ascans ascans(一) (-) (-)
638606(+8〉 |6(+4) 73 69 78
=Keratitis superficials diffusa
(m 4Sh仰附吋helliphellip ws吋巾叫ttha 討im凶凶山山山helliph伽刷a訂凶打吋一KSD
抗t helliphellipS油山山helliphellip加伽凶hellips出山脳 加凶凶叫山山江愉凶O叩一hellip iri凶a la
body and pellagra in c1inical f自indingfor instance disturbed liver functionanacidity I in gastric juiceand ophthalmological五ndings )
various skin diseases It will be seen that no small number of patients beginning with
patients with eczemaare attended by disturbed thiamine metabolism We wish to call
your attention to the fact thatas shown in Tab 3 metabolic insu伍 ciencyof thiamine
was seen more commonly in patients with eczema who have the lesions in the exposed
part of the skin It is also of interest that the findings of gastric juiceeye and blood in
inany of these patients were near1y the same as the findings in patients with pellagra as
shown in Tab 4
Tab 5 gives the results of tests for blood pyruvate levels in 87 patients Tab 6 shows
Tab 5 Blood Level of Pyruvate in Eczema and Dermatitis
Noof icnaesdDiseases es INormall Suboptimal Abnormal exam
toi1et dermatitjs
contact dermatitis
dermatitis of exposed area
eczeme ani et vulvae
eczema tyloticum rhagadiforme
eczeme mamrnae
eczerna capiliti
other acute or chronic eczema
eczerna of exposed area
chronic eczema
7
13
4
4
3
2
2
18
13
21
5
7 2
2
2
2
12
2
10
1
1
24 3
1
5
2
2
1 2
11
8
[TO山 7 j(5払 11 32 (12) (38)
Tab 6 Blood Level of Riboflavin in Various Diseases of the Skin (Average)μgdl
同二ょzzs|totaldbona叫 es附 ribo白川 rateof e町
norrnal rnen 9485
acute eczema 8711
chronic eczema 8275
dermatitis 8421
seborrheic dermatitis 8689
erythroderma 9030
erytherna multiforme 8521
So called ariboflavinosis 7548
ariboflavinosis 7271
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -63-
the results of tests for riboflavin levels and their relation to skin diseases in 317 patients
and Tab 7 gives the results of similar tests on pyrodoxine It is strange there should be
no disturbance of pyridoxine metabolism in the so-called seborrheic dermatitis
The results of experiments shown so far indicate that there is a disturbance of meta-
bolism of vitamin B-complex in a large proportion of patients with eczema dermatitis
erythroderma lupus erythematodes disseminatus and psoriasis In fact adminiatration of
vitamin Bcomplex has had effects in these patients In Tab 8--9 are listed the skin 同
diseases in which vitamins may be used with some effects
Tab 7 Metabolism of Vitamin B6 in Various Diseases of the Skin (Results
of Load Test of Vitamin B6)
DiseasesNormal Suboptimal Defici削
4
2
5
3
eczema 2
dermatitis 12 seborrheic dermatitis
2 erythroderm ia 4
psonasls 12 d
τ
i
T
i
urticaria
erytheina todes 11 muco cutaneoussyndrome
2 1
erythema nodosum
acne vulgaris 1 1
skin carcinoma 11 Pegets disease 1 leucamia cutis
neurosyphilis 1
chei1itis 1
drug eruption 1
spontaneous gangrane 1
hysterical gangrane 1
Total 22 13 13
Tab 8 Derinal Manifestation Vttamins Deficiency and their
application to Skin Diseases
つ
Vitamin Animal
rabbit depilation as alopecia areata
thiamile mouse roughness of the hair
h川町 mati出 depilation
pig dermatitis
riboflavin
Human Indicat面白 of Skin
Diseases
paleness of the skin allergic dermatoses pellagra
disa ppearance of alopecia areata herpes skin-elasticity (Elson) zoster psoriasis vulgaris
seborrhoeic dermatitis on 1 ariboflavinosis pellagra the nasolabial folds yen sunlight Dermatitis eyelid and ear1aps 1 facial desquamative cheilitisstomatitis eczema rosacea sycosis angularis (Sebrel amp 1 vulgaris eczema Butler) scrotal derma- infantiledermatitis 1 titis erythematous 1 seborrhoeic eczema
ldqumtinnthhdl b hidmtiti of the elbow acne like acne vulgaris1
lesion (Nakagawa Yasu
da) glossitis (Kruse Jollife)
-64- Vitamin B Complex and LiveI Function in Skin Diseases 第 38巻
a Ipellagra
3
m
HU
JA
一
白
》一
即
日
一
剖ヨ
一
一 一一一
一
直一一一
刀
副
一一一 一 一 一一副
一
ザ
日
目
陥
一
件
山
中
pellagraerythematodesd
pg
Lm
m
dE
T
n
U 1
1
e
l
a
e
-
-
e
g
g
m
SO
d
m
-
h
u
V
l
i
o
c|
|
e
r
山
田
加
は
出
田
立
コ
xeroderma pigmentosum rosaceasunlight
dhellip| chronic urticaria
ipb
i出 pernio戸阿阿訂的
strophtllus infantum
seborrhoeic dermatitis m E
A
B
cheilitis stomatitis
北
孔
amp
infantile seborrheic glossitis dermatitisacne vulgaris
田βhsod
m
w
u
cmu
z
e
a
n
ummagm
引
げ
口
口
dmぼ珂比
配川
infinlmT
ndpd
抗
町
民
出幻
qu
pellagra-like dermatitis allergic derniatoses (caused by Muller-V ilter by the use of desoxypyridoxine)
M
h
a
p
a
o
t
-
- 一 eηy訂 r凶r円humO
spaba
PC m
Um
tι
白」
imouse emhematous idryness of the skin-(e巾 hrodermiaexfoliativa idesquamative dermatitisI pityriasislike desquama-I (Leiner)
itamin H rat depigmentation tive de~-ati~ ~n t~ ~eor7~eic dermatitis
此凶丸山
ethii~tJtn) I ~~e~~~~~~~S_~~~stric- ~~~a__n山 eαemaIker)desquamative Iacne vulgari dermatitis of exposed
area (Williams)
出
副日九川
IpoliosiserythematodesZ52立おI ion d~~~~出s herpetiformisrat de仰向凶
Duhring
inositolrat atrichosis
listryke叶 lalbeisenfolic acid Irat depigmentation Isyndrome
hn 同 poliosisalopecia江
I
DA L 創ゐ psoriasis vulgaris唄1
d 唱
し
Tab9
日 剖 内
口
旧いに副
ほ
ddH
a-u
+Lt
e
mMne
QU
eneb唱
胃
げ
eaQUS
vzykFn
trF
hEKI
epenu
EA4Eb
C
F
GV
vitamin Bロ
江
I配sC問 eydryness of the I~戸igmenvitamin c | S kinMic伽allergic dermatoses
keratose (Crandon)
follicular keratose Ikeratose Vitamin A Iryness o~ the ~10n follic山 rkeratoseI
Ihyposecretion of Sweet Iichytyosis (FrazierFu) Ikeratosis follicularis
(T ab helliphellipmωnhellipih凶凶耐fe百
the left cornerand skin lesion caused by Vitamin B complex in man in the midle I At the right corner dermatoses in which B complex may have some effects are listed)
The relation between liver function and skin diseases has attracted the attention of
various investigators Disturbed liver function tends to lead to disturbed metabolism of
vitamins Sothe relation between the two cannot be overlooked
Tob 10-11 show the relation of thiamine and ribo自avinto liver function It will be
seen that liver function is related to metabolic disturbence of thiamine and ribofiavin
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
-62- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
asthenic feeling
ultra~violet-ray test
parasitism
serum protein
(+)
(-)
(十十〉
(一)
(+)
(一)
(一)
78
(-) (-)
(-) (一) I(一) I(一) (一〉 (-) (-)
(一) I (一 )ascans ascans(一) (-) (-)
638606(+8〉 |6(+4) 73 69 78
=Keratitis superficials diffusa
(m 4Sh仰附吋helliphellip ws吋巾叫ttha 討im凶凶山山山helliph伽刷a訂凶打吋一KSD
抗t helliphellipS油山山helliphellip加伽凶hellips出山脳 加凶凶叫山山江愉凶O叩一hellip iri凶a la
body and pellagra in c1inical f自indingfor instance disturbed liver functionanacidity I in gastric juiceand ophthalmological五ndings )
various skin diseases It will be seen that no small number of patients beginning with
patients with eczemaare attended by disturbed thiamine metabolism We wish to call
your attention to the fact thatas shown in Tab 3 metabolic insu伍 ciencyof thiamine
was seen more commonly in patients with eczema who have the lesions in the exposed
part of the skin It is also of interest that the findings of gastric juiceeye and blood in
inany of these patients were near1y the same as the findings in patients with pellagra as
shown in Tab 4
Tab 5 gives the results of tests for blood pyruvate levels in 87 patients Tab 6 shows
Tab 5 Blood Level of Pyruvate in Eczema and Dermatitis
Noof icnaesdDiseases es INormall Suboptimal Abnormal exam
toi1et dermatitjs
contact dermatitis
dermatitis of exposed area
eczeme ani et vulvae
eczema tyloticum rhagadiforme
eczeme mamrnae
eczerna capiliti
other acute or chronic eczema
eczerna of exposed area
chronic eczema
7
13
4
4
3
2
2
18
13
21
5
7 2
2
2
2
12
2
10
1
1
24 3
1
5
2
2
1 2
11
8
[TO山 7 j(5払 11 32 (12) (38)
Tab 6 Blood Level of Riboflavin in Various Diseases of the Skin (Average)μgdl
同二ょzzs|totaldbona叫 es附 ribo白川 rateof e町
norrnal rnen 9485
acute eczema 8711
chronic eczema 8275
dermatitis 8421
seborrheic dermatitis 8689
erythroderma 9030
erytherna multiforme 8521
So called ariboflavinosis 7548
ariboflavinosis 7271
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -63-
the results of tests for riboflavin levels and their relation to skin diseases in 317 patients
and Tab 7 gives the results of similar tests on pyrodoxine It is strange there should be
no disturbance of pyridoxine metabolism in the so-called seborrheic dermatitis
The results of experiments shown so far indicate that there is a disturbance of meta-
bolism of vitamin B-complex in a large proportion of patients with eczema dermatitis
erythroderma lupus erythematodes disseminatus and psoriasis In fact adminiatration of
vitamin Bcomplex has had effects in these patients In Tab 8--9 are listed the skin 同
diseases in which vitamins may be used with some effects
Tab 7 Metabolism of Vitamin B6 in Various Diseases of the Skin (Results
of Load Test of Vitamin B6)
DiseasesNormal Suboptimal Defici削
4
2
5
3
eczema 2
dermatitis 12 seborrheic dermatitis
2 erythroderm ia 4
psonasls 12 d
τ
i
T
i
urticaria
erytheina todes 11 muco cutaneoussyndrome
2 1
erythema nodosum
acne vulgaris 1 1
skin carcinoma 11 Pegets disease 1 leucamia cutis
neurosyphilis 1
chei1itis 1
drug eruption 1
spontaneous gangrane 1
hysterical gangrane 1
Total 22 13 13
Tab 8 Derinal Manifestation Vttamins Deficiency and their
application to Skin Diseases
つ
Vitamin Animal
rabbit depilation as alopecia areata
thiamile mouse roughness of the hair
h川町 mati出 depilation
pig dermatitis
riboflavin
Human Indicat面白 of Skin
Diseases
paleness of the skin allergic dermatoses pellagra
disa ppearance of alopecia areata herpes skin-elasticity (Elson) zoster psoriasis vulgaris
seborrhoeic dermatitis on 1 ariboflavinosis pellagra the nasolabial folds yen sunlight Dermatitis eyelid and ear1aps 1 facial desquamative cheilitisstomatitis eczema rosacea sycosis angularis (Sebrel amp 1 vulgaris eczema Butler) scrotal derma- infantiledermatitis 1 titis erythematous 1 seborrhoeic eczema
ldqumtinnthhdl b hidmtiti of the elbow acne like acne vulgaris1
lesion (Nakagawa Yasu
da) glossitis (Kruse Jollife)
-64- Vitamin B Complex and LiveI Function in Skin Diseases 第 38巻
a Ipellagra
3
m
HU
JA
一
白
》一
即
日
一
剖ヨ
一
一 一一一
一
直一一一
刀
副
一一一 一 一 一一副
一
ザ
日
目
陥
一
件
山
中
pellagraerythematodesd
pg
Lm
m
dE
T
n
U 1
1
e
l
a
e
-
-
e
g
g
m
SO
d
m
-
h
u
V
l
i
o
c|
|
e
r
山
田
加
は
出
田
立
コ
xeroderma pigmentosum rosaceasunlight
dhellip| chronic urticaria
ipb
i出 pernio戸阿阿訂的
strophtllus infantum
seborrhoeic dermatitis m E
A
B
cheilitis stomatitis
北
孔
amp
infantile seborrheic glossitis dermatitisacne vulgaris
田βhsod
m
w
u
cmu
z
e
a
n
ummagm
引
げ
口
口
dmぼ珂比
配川
infinlmT
ndpd
抗
町
民
出幻
qu
pellagra-like dermatitis allergic derniatoses (caused by Muller-V ilter by the use of desoxypyridoxine)
M
h
a
p
a
o
t
-
- 一 eηy訂 r凶r円humO
spaba
PC m
Um
tι
白」
imouse emhematous idryness of the skin-(e巾 hrodermiaexfoliativa idesquamative dermatitisI pityriasislike desquama-I (Leiner)
itamin H rat depigmentation tive de~-ati~ ~n t~ ~eor7~eic dermatitis
此凶丸山
ethii~tJtn) I ~~e~~~~~~~S_~~~stric- ~~~a__n山 eαemaIker)desquamative Iacne vulgari dermatitis of exposed
area (Williams)
出
副日九川
IpoliosiserythematodesZ52立おI ion d~~~~出s herpetiformisrat de仰向凶
Duhring
inositolrat atrichosis
listryke叶 lalbeisenfolic acid Irat depigmentation Isyndrome
hn 同 poliosisalopecia江
I
DA L 創ゐ psoriasis vulgaris唄1
d 唱
し
Tab9
日 剖 内
口
旧いに副
ほ
ddH
a-u
+Lt
e
mMne
QU
eneb唱
胃
げ
eaQUS
vzykFn
trF
hEKI
epenu
EA4Eb
C
F
GV
vitamin Bロ
江
I配sC問 eydryness of the I~戸igmenvitamin c | S kinMic伽allergic dermatoses
keratose (Crandon)
follicular keratose Ikeratose Vitamin A Iryness o~ the ~10n follic山 rkeratoseI
Ihyposecretion of Sweet Iichytyosis (FrazierFu) Ikeratosis follicularis
(T ab helliphellipmωnhellipih凶凶耐fe百
the left cornerand skin lesion caused by Vitamin B complex in man in the midle I At the right corner dermatoses in which B complex may have some effects are listed)
The relation between liver function and skin diseases has attracted the attention of
various investigators Disturbed liver function tends to lead to disturbed metabolism of
vitamins Sothe relation between the two cannot be overlooked
Tob 10-11 show the relation of thiamine and ribo自avinto liver function It will be
seen that liver function is related to metabolic disturbence of thiamine and ribofiavin
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -63-
the results of tests for riboflavin levels and their relation to skin diseases in 317 patients
and Tab 7 gives the results of similar tests on pyrodoxine It is strange there should be
no disturbance of pyridoxine metabolism in the so-called seborrheic dermatitis
The results of experiments shown so far indicate that there is a disturbance of meta-
bolism of vitamin B-complex in a large proportion of patients with eczema dermatitis
erythroderma lupus erythematodes disseminatus and psoriasis In fact adminiatration of
vitamin Bcomplex has had effects in these patients In Tab 8--9 are listed the skin 同
diseases in which vitamins may be used with some effects
Tab 7 Metabolism of Vitamin B6 in Various Diseases of the Skin (Results
of Load Test of Vitamin B6)
DiseasesNormal Suboptimal Defici削
4
2
5
3
eczema 2
dermatitis 12 seborrheic dermatitis
2 erythroderm ia 4
psonasls 12 d
τ
i
T
i
urticaria
erytheina todes 11 muco cutaneoussyndrome
2 1
erythema nodosum
acne vulgaris 1 1
skin carcinoma 11 Pegets disease 1 leucamia cutis
neurosyphilis 1
chei1itis 1
drug eruption 1
spontaneous gangrane 1
hysterical gangrane 1
Total 22 13 13
Tab 8 Derinal Manifestation Vttamins Deficiency and their
application to Skin Diseases
つ
Vitamin Animal
rabbit depilation as alopecia areata
thiamile mouse roughness of the hair
h川町 mati出 depilation
pig dermatitis
riboflavin
Human Indicat面白 of Skin
Diseases
paleness of the skin allergic dermatoses pellagra
disa ppearance of alopecia areata herpes skin-elasticity (Elson) zoster psoriasis vulgaris
seborrhoeic dermatitis on 1 ariboflavinosis pellagra the nasolabial folds yen sunlight Dermatitis eyelid and ear1aps 1 facial desquamative cheilitisstomatitis eczema rosacea sycosis angularis (Sebrel amp 1 vulgaris eczema Butler) scrotal derma- infantiledermatitis 1 titis erythematous 1 seborrhoeic eczema
ldqumtinnthhdl b hidmtiti of the elbow acne like acne vulgaris1
lesion (Nakagawa Yasu
da) glossitis (Kruse Jollife)
-64- Vitamin B Complex and LiveI Function in Skin Diseases 第 38巻
a Ipellagra
3
m
HU
JA
一
白
》一
即
日
一
剖ヨ
一
一 一一一
一
直一一一
刀
副
一一一 一 一 一一副
一
ザ
日
目
陥
一
件
山
中
pellagraerythematodesd
pg
Lm
m
dE
T
n
U 1
1
e
l
a
e
-
-
e
g
g
m
SO
d
m
-
h
u
V
l
i
o
c|
|
e
r
山
田
加
は
出
田
立
コ
xeroderma pigmentosum rosaceasunlight
dhellip| chronic urticaria
ipb
i出 pernio戸阿阿訂的
strophtllus infantum
seborrhoeic dermatitis m E
A
B
cheilitis stomatitis
北
孔
amp
infantile seborrheic glossitis dermatitisacne vulgaris
田βhsod
m
w
u
cmu
z
e
a
n
ummagm
引
げ
口
口
dmぼ珂比
配川
infinlmT
ndpd
抗
町
民
出幻
qu
pellagra-like dermatitis allergic derniatoses (caused by Muller-V ilter by the use of desoxypyridoxine)
M
h
a
p
a
o
t
-
- 一 eηy訂 r凶r円humO
spaba
PC m
Um
tι
白」
imouse emhematous idryness of the skin-(e巾 hrodermiaexfoliativa idesquamative dermatitisI pityriasislike desquama-I (Leiner)
itamin H rat depigmentation tive de~-ati~ ~n t~ ~eor7~eic dermatitis
此凶丸山
ethii~tJtn) I ~~e~~~~~~~S_~~~stric- ~~~a__n山 eαemaIker)desquamative Iacne vulgari dermatitis of exposed
area (Williams)
出
副日九川
IpoliosiserythematodesZ52立おI ion d~~~~出s herpetiformisrat de仰向凶
Duhring
inositolrat atrichosis
listryke叶 lalbeisenfolic acid Irat depigmentation Isyndrome
hn 同 poliosisalopecia江
I
DA L 創ゐ psoriasis vulgaris唄1
d 唱
し
Tab9
日 剖 内
口
旧いに副
ほ
ddH
a-u
+Lt
e
mMne
QU
eneb唱
胃
げ
eaQUS
vzykFn
trF
hEKI
epenu
EA4Eb
C
F
GV
vitamin Bロ
江
I配sC問 eydryness of the I~戸igmenvitamin c | S kinMic伽allergic dermatoses
keratose (Crandon)
follicular keratose Ikeratose Vitamin A Iryness o~ the ~10n follic山 rkeratoseI
Ihyposecretion of Sweet Iichytyosis (FrazierFu) Ikeratosis follicularis
(T ab helliphellipmωnhellipih凶凶耐fe百
the left cornerand skin lesion caused by Vitamin B complex in man in the midle I At the right corner dermatoses in which B complex may have some effects are listed)
The relation between liver function and skin diseases has attracted the attention of
various investigators Disturbed liver function tends to lead to disturbed metabolism of
vitamins Sothe relation between the two cannot be overlooked
Tob 10-11 show the relation of thiamine and ribo自avinto liver function It will be
seen that liver function is related to metabolic disturbence of thiamine and ribofiavin
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
-64- Vitamin B Complex and LiveI Function in Skin Diseases 第 38巻
a Ipellagra
3
m
HU
JA
一
白
》一
即
日
一
剖ヨ
一
一 一一一
一
直一一一
刀
副
一一一 一 一 一一副
一
ザ
日
目
陥
一
件
山
中
pellagraerythematodesd
pg
Lm
m
dE
T
n
U 1
1
e
l
a
e
-
-
e
g
g
m
SO
d
m
-
h
u
V
l
i
o
c|
|
e
r
山
田
加
は
出
田
立
コ
xeroderma pigmentosum rosaceasunlight
dhellip| chronic urticaria
ipb
i出 pernio戸阿阿訂的
strophtllus infantum
seborrhoeic dermatitis m E
A
B
cheilitis stomatitis
北
孔
amp
infantile seborrheic glossitis dermatitisacne vulgaris
田βhsod
m
w
u
cmu
z
e
a
n
ummagm
引
げ
口
口
dmぼ珂比
配川
infinlmT
ndpd
抗
町
民
出幻
qu
pellagra-like dermatitis allergic derniatoses (caused by Muller-V ilter by the use of desoxypyridoxine)
M
h
a
p
a
o
t
-
- 一 eηy訂 r凶r円humO
spaba
PC m
Um
tι
白」
imouse emhematous idryness of the skin-(e巾 hrodermiaexfoliativa idesquamative dermatitisI pityriasislike desquama-I (Leiner)
itamin H rat depigmentation tive de~-ati~ ~n t~ ~eor7~eic dermatitis
此凶丸山
ethii~tJtn) I ~~e~~~~~~~S_~~~stric- ~~~a__n山 eαemaIker)desquamative Iacne vulgari dermatitis of exposed
area (Williams)
出
副日九川
IpoliosiserythematodesZ52立おI ion d~~~~出s herpetiformisrat de仰向凶
Duhring
inositolrat atrichosis
listryke叶 lalbeisenfolic acid Irat depigmentation Isyndrome
hn 同 poliosisalopecia江
I
DA L 創ゐ psoriasis vulgaris唄1
d 唱
し
Tab9
日 剖 内
口
旧いに副
ほ
ddH
a-u
+Lt
e
mMne
QU
eneb唱
胃
げ
eaQUS
vzykFn
trF
hEKI
epenu
EA4Eb
C
F
GV
vitamin Bロ
江
I配sC問 eydryness of the I~戸igmenvitamin c | S kinMic伽allergic dermatoses
keratose (Crandon)
follicular keratose Ikeratose Vitamin A Iryness o~ the ~10n follic山 rkeratoseI
Ihyposecretion of Sweet Iichytyosis (FrazierFu) Ikeratosis follicularis
(T ab helliphellipmωnhellipih凶凶耐fe百
the left cornerand skin lesion caused by Vitamin B complex in man in the midle I At the right corner dermatoses in which B complex may have some effects are listed)
The relation between liver function and skin diseases has attracted the attention of
various investigators Disturbed liver function tends to lead to disturbed metabolism of
vitamins Sothe relation between the two cannot be overlooked
Tob 10-11 show the relation of thiamine and ribo自avinto liver function It will be
seen that liver function is related to metabolic disturbence of thiamine and ribofiavin
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -65-
Fig 4--5 show the results of investigations carried out in our c1 itl ic on the relation
between liver function and skin diseases The results of tests for fluctuations in serum
proteins and amino acids in the serum and urine perfarmed in association with liver
function tests are given in Tab 12-13
Tab 10 Liver Function and Thiamine Metabolism
cases in which
Mヤa加 13smtoyenns BSF
Takada unne unne dysfunction of Test urobilin urobilinogen
162 cases 172 cases 178 cases 169 cases liver were observed
174 cases
+
203 282十 163 247汁 91250 130 I 673 I 23 448523 96 567 I 53 556 23
Tab 11 Liver Functions and Riboflavin Metabolism
一一 ~11~ver~functions amount of 一B一2一一 amount of B2 in blood (arerage)μgdl
total B2 ester B2 I rate of ester
Cobalt reaction normal (74 cases)
left side reaction (59 cases)
right side reaction (50 cases)
606
606
577
527
506
477
8561
8465
8275
serum protein
below 64 (71 cases)
above 64 (63 cases) 577 464
633 539
8172
8472
urine urobilinogen
positive (91 cases)
negative (96 cases)
597 491 8263
615 523 8498
Eコ normal臨習 leftside reaction
亡コ normalabore 2cc 区週土 betwe印1 5-19cc
尽~ nght sJde reactJOn ~ + below 149cc
20 40 ω 100 5030 70 10 acute eczema acute eczema
chronic eczema chronic eczema
dermatitis dermatitis
toxic exanthema toxic exanthema
urticaria urticaria
pruritus pruritus
erythrodermia erythrodermia pityriasis rubra pityriasis rubra erythematodes erythematodes pyodermia pyodermia
Fig 4 Cobalt Reaction in 1236 Fig 5 Grops Reaction m 1217 Cascs of Various Skin cases of Various Skin
Diseases Diseases
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
-66- Vitamin B Complex and Liver Function in Skin Diseases 第 38巻
Tabo 12 Serum Protein Fractions in Various Skin Diseases
cases total
四
四
間
AjGα-Gl βGl r-G1Al
町
内
disease lncrease lncrease reversedecrease mcreaseNoof dpercoreteaIsne
lsquo 叫刊
exam
唱
則~30137ト515 358~492307~439 239--355 075--67
dermatitis
38eczema
170--282
erythrodermia
435--564473--603528--645291~40346 92~182
20 100 60 60 40 5
司ワ臼
p(EiZteybrriaas〉is rubra 5 40 80 60 60 80 80
6drug eruption 17 50 33 33 50 33
salvalsan 4 50 75 50 75 25dermatitis
ヴ
alimeOnStIaSry 0 50 50 25 04toxic
urticaria 12 33 12
psonasls
9
30 20 30 50 20 10
司ヴ
20 60 50 60 50 4010emruytlthiefomrame
100 100pellagra 2 100 50
erythematodes 7 14 100 14 43 86 43
ichtyosis 50 50 50 50 50
pems carcmoma 0 100 100 100 100 100
poFHU
AU
t t dTotale 27唱
VE
lLg e--c
ac
d4a
-aA
Tab 13 Skin Diseases in Which Notable Increase and Decrease of Free
Amino Acid in Serum and Urine were Observed (200 cases)
serum urme
lncrease decrease mcrease decrease
I~山eoxyProlineacute eczema a
g
g
EA
一一一一一一一一
日
一出戸
一すlsquo〈山
町勾
ennyeaannem O
K
teaneous
-m EEAO
hlhellipalanine henYl-1
l向 ny凶 ninegmlyetcTilnioenine erythrodermia
phaleinnyelalanine valine
alanine lysinep(Hiteybriraas)is rubra leucine methioninetyrosine
phenylalaninecollagen 1F1ycm
threoninehistidinedisease tyrosinephenylalanine
且
In view of the results of our experimentswe wお hto emphasize that liver function and
(helliphelliphelliphelliphellip helliphellip sses
metablism of vitaminsplay a significant part in the etiology of skin diseases
originally as manuhellip)ωbe made at Univers比 isand hellipes in the U S AEurope and India d
authors tour of inspectlOn from September 1960 to January 1961
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~
第 1号 Vitamin B Complex and Liver Function in Skin Diseases -67-
References
HasizumeK Jap J of Derm683291958
2) BaronE S G J Invest Derm~ 11971948
~