cytokines dr.marián sabol, phd. p.j. Šafárik university, medical faculty, institute of medical...
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Cytokines
Dr.Marián Sabol, PhD.
P.J. Šafárik University, Medical Faculty, Institute of Medical MicrobiologyTr. SNP 1, Košice, Slovakia
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Definition
-Low molecular non-antibody proteins
-Secreted by leukocytes and some non-leukocytic cells
- Act as intercellular mediators
- They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialised glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
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Functions of Cytokines
1.Development of cellular and humoral immune responses
2.Induction of the inflammatory response
3.Regulation of hematopoiesis
4.Control of cellular proliferation and differentiation
5. Healing of wounds
* Although the immune response to a specific Ag includes the production ofd of cytokines, cytokines act in an Ag-nonspecific manner.
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Properties of cProperties of cytokinesytokines
Autocrine,
Paracrine and
Endocrine Action
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Cytokine Cytokine networknetwork
Pleiotropy,
Redundancy,
Synergy,
Antagonism
of Cytokines
PLEIOTROPY
REDUNDANCY
ANTAGONISM
SYNERGY
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Cytokine Cytokine networknetwork
Cascade Induction
of Cytokines
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Plasma Cell
Inflammatory response
Clonalexpansion
T cell
LAK
NK
ActivatedB cell
Mast cell
Stem cell
Hematopoiesis
Endothelial cellsFibroblasts
Hypotalamus
Neutrophil
Antigen
RestingB cell
Mph
Resting T cell Eosinophils
Th
TNF IL-1
TGF- PDGF
TNF IL- 1
IL- 1, 6, 11, 12TNF, CSFsIL- 1,6,8,
IL-10,12,15IFN , TNF-
Antigen
IL-3,6,7GM-CSFIL- 3,4,10
IL- 3,5
IL-2
IL-2,4,5,13TGF-IFN-
IL-4
IL –10,4
IL -2 TGF-
IL-6
IL-3,4.10,13IFN-, TNF-
IL-8, TNF-
IL-1,6 TNF-
IL-2 IFN- IL-15
IL-2 IL-12 (APC) IL-15 IL-2
IL-2
IL-12(via APC)
IL-2 IFN-
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Th1Th1 / / Th2Th2
Regulation of TH Subsets by Cytokines
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TH1 Response
-cell-mediated functions (e.g., delayed-type hypersensitivity and activation of TC cells)
-Production of IgG3, IgG1, IgG2 (opsonization and C activation).-Excessive inflammation and tissue injury.- Target: viral infections and intracellular pathogens. ( IL-2, IFNand TNF)
- IFN also inhibits the expansion of the TH2 population.
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TH2 Response
-Stimulates eosinophil activation and differentiation
- Provides help to B cells, and promotes the production
of relatively large amounts of IgM, IgE, and IgG4
-Supports allergic reactions.
The production of Il-4, IL-5 and IL-10 promotes the function of IgE and eosinophils on the anti-helminth (round worm) immunity.
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