curriculum vitae scott david boden, md ...ortho.emory.edu/documents/cvs/boden.scottd 2012.pdflange...

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CURRICULUM VITAE SCOTT DAVID BODEN, MD Current Address: The Emory Spine Center 59 Executive Park South, Suite 3000 Atlanta, GA 30329 HIGH SCHOOL EDUCATION: Livingston High School 9/75 — 6/78 Livingston, NJ National Honor Society Who's Who in Music 1978 UNDERGRADUATE EDUCATION: University of Pennsylvania, Philadelphia, PA 9/78 — 5-82 Bachelor of Arts, Chemistry Honors: Summa Cum Laude Phi Lambda Upsilon Honorary Chemical Society Alpha Epsilon Delta Honor Society Sphinx Senior Honor Society "Spade" Senior Class Honor Award Marching Band - Drum Major Conductor, Lead Trombone MEDICAL EDUCATION: University of Pennsylvania School of Medicine 8/82 — 5/86 Philadelphia, PA Doctor of Medicine Honors: Alpha Omega Alpha Medical Honor Society Morton McCutcheon Memorial Prize for meritorious laboratory research Lange Medical Book Award for outstanding scholarship and extracurricular contributions POST-GRADUATE MEDICAL TRAINING: General Surgery Internship, George Washington University Medical Center 7/86 — 6/87 Orthopaedic Surgery Residency, George Washington University Medical Center 7/87 — 6/91 Spinal Surgery Fellowship, Henry H. Bohlman, M.D. 7/91 — 6/92 Case Western Reserve University ACADEMIC APPOINTMENTS: Director, The Emory Orthopaedics & Spine Center 1/1/04 Professor of Orthopaedic Surgery (with tenure) 9/1/01 Professor of Orthopaedic Surgery 9/1/00 Associate Section Chief, Department of Orthopaedic Surgery 1/1/98 Associate Professor of Orthopaedic Surgery 9/1/95 Director, The Emory Spine Center 1/1/94 Clinical Director, Whitesides Orthopaedic Research Laboratory 1/1/93 Assistant Professor of Orthopaedic Surgery 8/1/92 MEDICAL LICENSURE: Georgia # 35566 CERTIFICATION: Diplomate of the American Board of Orthopaedic Surgery (Recertified 9/03) 7/94 Fellow of the American Academy of Orthopaedic Surgeons 2/96 Scott D. Boden, MD July, 2011 1

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Page 1: CURRICULUM VITAE SCOTT DAVID BODEN, MD ...ortho.emory.edu/documents/cvs/Boden.ScottD 2012.pdfLange Medical Book Award for outstanding scholarship and extracurricular contributions

CURRICULUM VITAE

SCOTT DAVID BODEN, MD

Current Address: The Emory Spine Center 59 Executive Park South, Suite 3000

Atlanta, GA 30329 HIGH SCHOOL EDUCATION: Livingston High School 9/75 — 6/78 Livingston, NJ

National Honor Society Who's Who in Music 1978

UNDERGRADUATE EDUCATION: University of Pennsylvania, Philadelphia, PA 9/78 — 5-82 Bachelor of Arts, Chemistry Honors:

Summa Cum Laude Phi Lambda Upsilon Honorary Chemical Society Alpha Epsilon Delta Honor Society Sphinx Senior Honor Society "Spade" Senior Class Honor Award Marching Band - Drum Major Conductor, Lead Trombone

MEDICAL EDUCATION: University of Pennsylvania School of Medicine 8/82 — 5/86 Philadelphia, PA Doctor of Medicine Honors:

Alpha Omega Alpha Medical Honor Society Morton McCutcheon Memorial Prize for meritorious laboratory research Lange Medical Book Award for outstanding scholarship and extracurricular contributions

POST-GRADUATE MEDICAL TRAINING: General Surgery Internship, George Washington University Medical Center 7/86 — 6/87 Orthopaedic Surgery Residency, George Washington University Medical Center 7/87 — 6/91 Spinal Surgery Fellowship, Henry H. Bohlman, M.D. 7/91 — 6/92 Case Western Reserve University ACADEMIC APPOINTMENTS: Director, The Emory Orthopaedics & Spine Center 1/1/04 Professor of Orthopaedic Surgery (with tenure) 9/1/01 Professor of Orthopaedic Surgery 9/1/00 Associate Section Chief, Department of Orthopaedic Surgery 1/1/98 Associate Professor of Orthopaedic Surgery 9/1/95 Director, The Emory Spine Center 1/1/94 Clinical Director, Whitesides Orthopaedic Research Laboratory 1/1/93 Assistant Professor of Orthopaedic Surgery 8/1/92 MEDICAL LICENSURE:

Georgia # 35566

CERTIFICATION: Diplomate of the American Board of Orthopaedic Surgery (Recertified 9/03) 7/94 Fellow of the American Academy of Orthopaedic Surgeons 2/96

Scott D. Boden, MD July, 2011 1

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HOSPITAL APPOINTMENTS: Physician, Veterans Administration Hospital, Decatur, GA 8/1/92 Emory University Hospital, Atlanta, GA 8/1/92 Grady Memorial Hospital, Atlanta, GA 8/1/92

OTHER POSITIONS HELD:

Chairman and Founder, National Spine Network 2/95 – present MEMBERSHIP IN MEDICAL SOCIETIES:

American Medical Association 1982 – present Orthopaedic Research Society 1989 – present American Society for Bone and Mineral Research 1993 – present International Society for Study of the Lumbar Spine 1993 – present North American Spine Society 1993 – present Eastern Orthopaedic Association 1996 – present American Academy of Orthopaedic Surgeons 1996 – present Atlanta Orthopaedic Society 1994 – present Medical Association of Georgia 1992 – present DeKalb County Medical Society 1992 – present Kelly Orthopaedic Society 1993 – present Georgia Orthopaedic Society 1995 – present American Orthopaedic Association 1999 – present President-Elect 2012 American Society for Gene Therapy 2000 – present

Scott D. Boden, MD July, 2011 2

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Patents:

Patents Issued: 1. Patent 5,741,261 issued 4/21/98 to SDGI Holdings, Inc. 2. Patent 5,885,291 issued 3/23/99 to SDGI Holdings, Inc. 3. Patent 5,885,292 issued 3/23/99 to SDGI Holdings, Inc. 4. Patent 5,891,147 issued 4/6/99 to SDGI Holdings, Inc

“Minimally Invasive Spinal Surgical Methods and Instruments” with P.A. Moskovitz, W.F. McKay, and J. Moctezuma

5. Patent 6,300,127 issued 10/9/01 to Emory University 6. Patent 6,444,803 issued 10/02 to Emory University “Bone Mineralization Proteins, DNA, Vectors, Expression Systems” 7. Patent 7,504,374 issued 3/17/09 to SDGI Holdings, Inc

“Method for inducing deposition and maturation of bone comprising a…. with JC Marx, and WF McKay

8. Patent 7,517,866 issued 4/14/09 to Emory University “LIM mineralization protein splice variants” 9. Patent 7,537,902 issued 5/26/09 to Emory University “Methods and kits using a molecular interaction between a Smurf-1 WW domain….” 10. Patent 7,671,014 issued 3/2/10 to SDGI Holdings, Inc “Flowable carrier matrix and methods for delivering to a patient” with N Beals, JL Scifert 11. Patent 7,691,814 issued 4/6/10 to Emory University. “Osteogenic compositions comprising an amino acid sequence capable of being…” 12. Patent 7,722,895 issued 5/26/10 to SDGI Holdings, Inc. “Osteogenic implants with combined implant materials, and materials….” 13. Patent 7,741,117 issued 6/22/10 to Emory University

“Bone mineralization protein expression systems, and methods of studying and methods of studying intracellular signaling pathways induced thereby” with FL Titus, S Sangadala

14. Patent 7,781,574 issued 8/24/10 to Emory University “Chimeric osteogenic factor containing proteins capable of increased nuclear….” 15. Patent 7,847,072 issued 12/7/10 to Sulzer Orthopaedics

“Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue” with K Thorne

16. Patent 7,892,532 issued 2/22/11 to SDGI Holdings, Inc. “Intracellular delivery of osteoinductive proteins and peptides” with FL Titus, JC Marx, ST Yoon, S Drapeau

17. Patent 7,897,564 issued 3/1/11 to SDGI Holdings, Inc. “Flowable carrier matrix and methods for delivering to a patient” with N Beals, JL Scifert 18. Patent 7,923,250 issued 4/12/11 to SDGI Holdings, Inc.

“Methods of expressing LIM mineralization protein in non-osseous cells” with WF McKay, ST Yoon

Scott D. Boden, MD July, 2011 3

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HONORS AND AWARDS:

Washington Orthopaedic Society Resident Research Award 1988

Eastern Orthopaedic Association Resident/Fellow - Research Award 1988

Washington Orthopaedic Society Resident Research Award 1989

Eastern Orthopaedic Association Resident/Fellow - Research Award 1989

Southern Orthopaedic Association Resident Research Award 1989

Washington Orthopaedic Society Resident Research Award 1990

American Orthopaedic Association (AOA) - Zimmer Resident Research Travel Award 1990

Acromed Award for Outstanding Spinal Research - (North American Spine Society) 1990

Washington Orthopaedic Society Resident Research Award 1991

American Orthopaedic Association (AOA) - North American - Traveling Fellowship 1991

St. Charles General Hospital Spine Essay Award 1992

Acromed Award for Outstanding Spinal Research - (North American Spine Society) 1992

American Orthopaedic Association (AOA)- Zimmer Fellow Research Travel Award 1992

Outstanding Clinical Research Paper Award - International Society for Study of the Lumbar Spine 1993

Russel Hibbs Research Award - (Scoliosis Research Society) 1994

Outstanding Research Paper Award - (North American Spine Society) 1994

Volvo Award for Low Back Research - (International Society for Study of the Lumbar Spine) 1995

Outstanding Research Paper Award - (North American Spine Society) 1996

Young Investigator Award - (American Society for Bone & Mineral Research) 1996

Mayfield Award - (American Association of Neurological Surgeons) 1997

Marshall R. Urist Young Investigator Award - (Association of Bone and Joint Surgeons) 1997

Eugene T. Nordby Award - (International Intradiscal Therapy Society) 1997

Outstanding Research Paper Award - (North American Spine Society) 1997

Volvo Award for Low Back Pain Research - (International Society for Study of the Lumbar Spine) 1998

Outstanding Research Paper Award - (North American Spine Society) 1998

Kappa Delta Young Investigator Award - (American Academy of Orthopaedic Surgeons) 1999

Outstanding Research Paper Award - (North American Spine Society) 2000

Outstanding Research Poster Award − (North American Spine Society) 2001

Volvo Award for Low Back Pain Research − (International Society for Study of the Lumbar Spine) 2002

Marshall Urist Award – (Pittsburgh Bone Symposium) 2003

Leon Wiltse Award – (North American Spine Society) 2003

Mayfield Award – (American Association of Neurological Surgeons) 2004

ISSLS Prize For Lumbar Spine Research 2004

Scoliosis Research Society Evidence Based Medicine Award 2006

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EDITORIAL BOARD POSITIONS:

Journal of Bone and Joint Surgery [Am], Consulting Editor of Research 2000 – present Journal of the American Academy of Orthopaedic Surgeons 1993 – 2001 Seminars in Spine Surgery, Editor of SPINESCOPE section 1993 – present Seminars in Spine Surgery, Co-Editor-In-Chief 1995 – present Spine, Deputy Editor 1999 – present Spine, Associate Editor 1993 –1998 Spine, Co-editor of Controversies Section 1994 –1998 The Back Letter 1995 – 2005 Journal of Bone and Mineral Research 1999 – 2002 Contemporary Spine Surgery 2000 – present Advances in Orthopaedic Surgery, Spine Section Editor 1996 – 2000 AAOS - Scientific Copy Editor of Academy News 1994 Orthopaedic Audio Synopsis 1991 – 1996 Orthopaedics Today, Spine Section Editor 2003 - Present

CONSULTANT REVIEWER:

Spine 1993 – present Journal of the American Academy of Orthopaedic Surgeons 1993 – present Journal of the American Medical Association 1994 – present Clinical Orthopedics and Related Research 1995 – present Journal of Bone and Mineral Research 1995 – present Journal of Orthopaedic Research 1996 – present Journal of Bone and Joint Surgery 1997 – present

RESEARCH FOCUS: Dr. Boden’s research has three primary areas. The first is cell/molecular biology of osteoblast differen-tiation including study of the mechanism of action of bone growth factors (BMPs). This research also involves local and regional gene therapy to regenerate bone. This research has evolved into the design and development of small drug-like molecules that will enhance bone formation locally, regionally, and possibly systemically. The second focus is a variety of animal models of spine fusion to understand the biology of the healing process and test the efficacy of various bone graft substitutes. The third focus is that of clinical outcomes research relating to spinal disorders, diagnostic imaging, and utilization of health care resources.

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NATIONAL/INTERNATIONAL COMMITTEES:

American Academy of Orthopaedic Surgeons Subcommittee on Basic Science Evaluation (Chair 1999-2006) 1995 – 2006

Biologic Implants Committee (Chair 2005-2011) 2000 – 2011 Counsel on Research, Quality, and Technology 2005 – 2011 The Orthopaedic Device Forum 2005 - 2011 Program Committee (Chair 2008) 2006 – 2010

Orthopaedic Research Society Program Committee, Ad Hoc Reviewer 1995 – 1996 Program Committee, 1 year member 2000 – 2001 Local Arrangements Chairperson 1996 Board of Directors, Ad Hoc Member 1995 – 1996 Education & Special Projects Committee, Chairman (1998-9) 1996 – 1999 Secretary 2003 − 2006

North American Spine Society Program Committee, member 1996 News Letter Advisory Panel 1996 – 2004 Collaborative Education Committee, Chairman 1996 – 2000 Professional Conduct and Ethics Committee, member 2006 – 2009

American Orthopaedic Association NATF Tour Coordinator 1996 NATF Tour Committee 1999 – 2001

ABC Exchange Fellowship Subcommittee 2001 – 2004 Board of Directors, Member-at-Large 2002 − 2004 Program Chairman – Annual Meeting 2005 Chair, Resident & Emerging Leaders Committee 2003 - 2008 Secretary (Executive Committee) 2006 – 2010 Presidential Line (President 2014) 2011 – 2016

International Society for Study of the Lumbar Spine Program Committee, Chairman (1999) 1996 – 1999 Secretary 2002 – 2005 Presidential Line (President – 2008) 2006 – 2009

NIH consensus Development Conference on Osteoporosis Panel Member 2000

Eastern Orthopaedic Association Board of Directors, Member At Large 1998 – 2001 Program Committee Chairman 2001 – 2002 Secretary 2003 – 2004 Presidential Line (President – 2007) 2004 – 2008 Board of Directors, Newsletter Editor 2009 - present

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UNIVERSITY/HOSPITAL COMMITTEES:

Emory University School of Medicine Rehabilitation Medicine Chairman Search Committee 1995 -1997 Rehabilitation Medicine Chairman Search Committee 2006 - 2007 Neurosurgery Chairman Search Committee, Ad Hoc Member 1995 Emergency Medicine Chairman Search Committee 1998

Emory Healthcare Marketing Subcommittee 1999 - 2009 Service Performance Enhancement Team 2000 – 2006 Clinical Integration Network Committee (Team Leader) 2011

The Emory Clinic, Inc. Operations Committee, Chairman 1998 - 2001 PARIT Steering Committee 1999 - 2001 Managed Care/ Fee Committee 1994 - 1998 Compensation Committee 1998 – 1999 SJH Physician Integration Committee 2011

Emory University Hospital Professional Services Committee 1998 – present

Courses Directed A Primary Care Update, Atlanta GA Date: March 31 – April, 2006 Credits: 14 hours Attendance: 150 A Primary Care Update, Atlanta GA Date: April 20 – 21, 2007 Credits: 15 hours Attendance: 150 A Primary Care Update, Atlanta GA Date: April 2008 Credits: 15 hours Attendance: 120 A Primary Care Update, Atlanta GA Date: April 2009 Credits: 15 hours Attendance: 130 A Primary Care Update, Atlanta GA Date: April 2010 Credits: 15 hours Attendance: 150 A Primary Care Update, Atlanta GA Date: April 29-30, 2011 Credits: 15 hours Attendance: 180

Course Faculty

Spine Study Group, Palm Beach, FL Date: May 3-6, 2007

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Topic Bone Graft Enhancers

AAOS Instructional Course #386, San Diego, CA Date: February 16, 2007 Topic Commonly Used Enhancers of Bone Healing – Mini Debates AAOS Instructional Course #214, San Francisco, CA Date: March 6, 2008 Topic: Bone Growth Factors for Spine Fusion AAOS Instructional Course #318, Las Vegas, NV Date: February 27, 2009 Topic: Safe Use of Biologics in the 21st Century

AAOS Instructional Course #244, New Orleans, LA Date: February 12, 2010 Topic: Safe Use of Biologics in the 21st Century AAOS Instructional Course #216, New Orleans, LA Date: February 12, 2010 Topic: The Art and Science of Reviewing Manuscripts for Orthopaedic Journals Spine Study Group, Palm Beach FL Date: May 14, 2010 Topic: The Separation of Industry and the Surgeon: How Far is Enough? AAOS Instructional Course #413, New Orleans, LA Date: February 18, 2011 Topic: The Art and Science of Reviewing Manuscripts for Orthopaedic Journals Spine Study Group, Palm Beach FL Date: May 18, 2011 Topic: The Seven Secrets of Highly Successful Spine Surgeons: How to Balance Work, Family, Academics, and Live the Dream INVITED LECTURES: Regional Surgeons, San Antonio, TX Date: January 21-28, 2006 Topic: Bone Graft Substitutes Regional Surgeons, San Francisco, CA Date: February 24-25, 2006 Topic: Bone Graft Substitutes Community Surgeons, Durham, NC Date: March 2, 2006 Topic: Bone Graft Substitutes Wake Medical Center Ground Rounds, Raleigh, NC Date: March 3, 2006 Topic: Bone Graft Substitutes Community Surgeons, Wilmington, NC Date: March 3, 2006 Topic: Bone Graft Substitutes Scott D. Boden, MD July, 2011 8

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Regional Surgeons, New York, NY Date: April 8-9, 2006 Topic: Bone Graft Substitutes Japan Spine Research Society (JSRS), Tokyo, Japan Date: April 22, 2006 Topic: Bone Graft Substitutes Spine Society of Australia, Sydney, Australia Date: April 29, 2006 Topic: Bone Graft Substitutes University of Washington Research Day Visiting Professor, Washington, DC Date: May 18-19, 2006 Topic: Resident Research Review Bone Graft Substitutes Orlando Regional Medical Center, Orlando, FL Date: February 1, 2007 Topic: Bone Graft Substitutes Yongdong Severance Hospital, Seoul, Korea Date: May 18, 2007 Topic: The Future Role of Molecular Biology in Spine Bone Graft Substitutes Columbia – NY Presbyterian Hospital, New York, NY Date: June 6-7, 2007 Topic: Resident Graduation Day Visiting Professor Bone Graft Substitutes Update ORS/AAOS Combined Symposium, San Francisco, CA Date: March 5, 2008 Topic: Growth Factor-Based Technologies American Orthopaedic Association Symposium, Quebec Date: June 6, 2008 Topic: Evidence-Based Approach to Brining New Orthopaedic Devices to Market Cedars Sinai Grand Rounds, Los Angeles CA Date: July 30, 2008 Topic: Bone Graft Substitutes UC Irvine Grand Rounds, Irvine, CA Date: July 31, 2008 Topic: Bone Graft Substitutes Miami/Toronto Bone Symposium, Orlando FL Date: November 1, 2008 Topic: Bone Regeneration in Spine Fusions Bone and Joint Decade Global Network Conference, Washington DC Date: October 23, 2009 Topic: Low Back Pain: Future Directions Scott D. Boden, MD July, 2011 9

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University of Miami Grand Rounds, Miami FL Date: November 19, 2009 Topic: Bone Graft Substitutes American Orthopaedic Foot & Ankle Society – Specialty Day, New Orleans, LA Date: March 13, 2010 Topic: Orthobiologics – Spine Surgeon’s Perspective Stanford University Dept of Orthopaedics Annual Research Day, Palo Alto, CA Date: March 26, 2010 Topic: Keynote Address: Bone Graft Substitutes: 2010 Update International Society for Study of the Lumbar Spine, Aukland NZ Date: April 16, 2010 Topic: Debate: Minimally Invasive Lumbar Discectomy for Sciatica (CON) American College of Rheumatology, Atlanta, GA Date: November 9, 2010 Topic: Marshall J. Schiff Memorial Lecture: Everything a Rheumatologist Should Know About Spine Surgery But Was Afraid to Ask Association of Spine Surgeons of India Annual Conference, Mumbai, India Date: January 27, 2011 Topic: Biology of Spine Fusion BMP Update 2011 AAOS Symposium, San Diego, CA Date: February 18, 2011 Topic: Osteoinductive/Osteopromotive Growth Factors Jefferson Orthopaedic Society Annual Meeting, Philadelphia, PA Date: May 6, 2011 Topic: BMP Update Beyond BMPs (Gartland Oration) Japanese Orthopaedic Association Annual Meeting, Tokyo, Japan Date: May 12, 2011 Topic: Use of BMPs in the Spine: 2011 Update American Orthopaedic Association Symposium, Boston, MA Date: June 23, 2011 Topic: Current Status of Osteoinductive Agents for Spine Fusion

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PUBLICATIONS JOURNAL ARTICLES: 1. Boden S.D., Kaplan F.S., Fallon M.D., Ruddy R., Belik J., Andlay E., Zackai E., and Ellis J.:

Metatrophic Dwarfism: Uncoupling of Endochondral and Perichondral Growth. J Bone Joint Surg, 69-A:174-185, February 1987. (Lead Article)

2. Kaplan F.S., Boden S.D., Fallon M.D., Schmidt R., and Haddad J.G.: Estrogen Receptors in

Osteoblasts in a Disorder of Trabecular Bone Remodeling. In International Symposium on Osteoporosis, ed. Jensen J., Riis B., and Christiansen C. Denmark: Norhaven A/S, 1987, p. 73.

3. Kaplan F.S., Fallon M.D., Boden S.D., et al.: Estrogen Receptors in Bone in Polyostotic Fibrous

Dysphasia (McCune-Albright Syndrome). New England Journal of Medicine, 319:421-425, 1988. 4. Joyce M.E., Boden S.D., Oliver B., Heydemann A., and Bolander M.E.: Analysis of Estrogen

Receptor Expression in Rat Fracture Healing by Polymerase Chain Reaction Amplification. Journal of Cellular Biochemistry, Supplement 13E, 1989.

5. Boden S.D., Lestini W.F., and Wiesel S.W.: Compensation Low Back Pain. Seminars in Spine

Surgery, 1(1):68-75, 1989. 6. Boden S.D., Goodenough D.J., Stockham C.D., Jacobs E., Dina T., and Allman R.M.: Precise

Measurement of Vertebral Bone Density Using Computed Tomography Without the Use of an External Reference Phantom. Journal of Digital Imaging, 2(1):31-38, 1989.

7. Boden S.D., Labropoulos P.A., Ragsdale B.D., Gullino P.M., and Gerber L.H.: Retinyl Acetate

Arthritis in C3H-Avy Mice. Arthritis and Rheumatism, 32:625-633, 1989. 8. Kaplan F.S., Dalinka M., Karp J.S., Fallon M.D., Katz M., Boden S.D., Simpson E., Attie M., and

Haddad J.G.: Quantitative Computed Tomography Reflects Vertebral Fracture Morbidity in Osteopenic Patients. Orthopaedics, 12:949-955, 1989.

9. McCowin P.R., Boden S.D., and Wiesel S.W.: Conservative Therapy for Spinal Stenosis. Seminars

in Spine Surgery, 1(3):155-162, 1989. 10. Boden S.D., Fallon M.D., Davidson R., Mennuti M.T., and Kaplan F.S.: Proximal Femoral Focal

Deficiency: Evidence for a Defect in Chondrocyte Proliferation and Maturation. J Bone Joint Surg, 71A:1119-1129, 1989. (Lead Article)

11. Boden S.D., Labropoulos P.A., McCowin P., Lestini W.F., Hurwitz S.R.: Mechanical Considerations

for the Syndesmosis Screw: A Cadaver Study. J Bone Joint Surg 71-A:1548-1555, 1989. 12. Boden S.D., Joyce M.E., Oliver B., Heydemann A., Bolander M.E.: Estrogen Receptor mRNA

Expression in Callus During Rat Fracture Healing. Rapid Communication. Calcified Tissue International, 45:324-325, 1989.

13. Boden S.D., and Wiesel S.W.: Conservative Treatment for Cervical Disc Disease. Seminars in

Spine Surgery, 1(4):229-232, 1989. 14. Boden S.D., and Kaplan F.S.: Calcium Homeostasis. Orthopaedic Clinics of North America, 21:31-

42, 1990. 15. Boden S.D., Labropoulos P.A., and Saunders R.: Hip Fractures In Young Patients: Is This Early

Osteoporosis? Calcified Tissue International, 46:65-72, 1990. (Lead Article) Scott D. Boden, MD July, 2011 11

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JOURNAL ARTICLES: (Cont.) 16. Boden S.D., Davis D.O., Dina T., Patronas N., and Wiesel S.W.: Abnormal Magnetic Resonance

Scans of the Lumbar Spine in Asymptomatic Subjects: A Prospective Investigation. J Bone Joint Surg, 72-A:403-408, 1990.

17. Boden S.D., McCowin P.R., Davis D.O., Dina T.S., Mark A.S., and Wiesel S.W.: Abnormal Magnetic

Resonance Scans of the Cervical Spine in Asymptomatic Subjects: A Prospective Investigation. J Bone Joint Surg, 72-A:1178-1184, 1990.

18. Boden S.D., and Wiesel S.W.: Lumbosacral Segmental Motion in Normal Individuals: Have We

Been Measuring Instability Properly? Spine, 15:571-576, 1990. 19. Boden S.D., Labropoulos P.A., Vailas J.C.: MRI of the Acute Knee Injury: It's Sensitive, But Is It

Cost Effective? Arthroscopy, 6:306-310, 1990. 20. Boden S.D., Davis D.O., Dina T.S., Parker C.P., O'Malley S., Sunner J.L., Wiesel S.W.: Contrast-

Enhanced MR Imaging Performed After Successful Lumbar Disc Surgery: Prospective Study. Radiology, 182:59-64, 1992.

21. Shellock F.G., Morris E., Deutsch A., Mink J.H., Kerr R., Boden S.D.: High Incidence of

Hematopoietic Hyperplasia on Knee MR Imaging Examinations of Asymptomatic Marathon Runners. Am. J. Radiology, 158:335-338, 1992.

22. Davis D.O., Boden S.D.: Modern Imaging of Degenerative Disease of the Lumbosacral Spine.

Seminars in Spine Surgery, 4:66-84, 1992. 23. Boden S.D., Davis D.O.: Imaging of the Postoperative Lumbar Spine. Seminars In Spine Surgery,

4:66-84, 1992. 24. Monaghan B.A., Kaplan F.S., Lyttle C.R., Fallon M.D., Boden S.D., and Haddad J.G.: Estrogen

Receptors in Fracture Healing. Clin Orthop 280:277-280, 1992. 25. Boden S.D., Davis D.O., Dina T.S., Stoller D.W., Brown S.D., Vailas J.C., Labropoulos P.A.: A

Prospective and Blinded Investigation of Magnetic Resonance Imaging of the Knee: Abnormal Findings in Asymptomatic Subjects. Clin Orthop 282:177-185, 1992.

26. Lowery W.D., Horn T.J., Boden S.D., Wiesel S.W.: Impairment Evaluation Based on Spinal Range

of Motion in Normal Subjects. J. Spinal Disorders, 5:398-402, 1992. 27. Boden S.D., Davis D.O., Dina T.S., Sunner J.L., Wiesel S.W.: Postoperative Discitis: Distinguishing

Early MR Findings from Normal Postoperative Disc Space Changes. Radiology 184:765-771, 1992. 28. Boden S.D.: Errors in Decision Making Following Radiographic Investigations of the Spine.

Seminars in Spine Surgery 5:90-100, 1993. 29. Boden S.D., Dodge L.D., Rechtine G.R., and Bohlman H.H.: Rheumatoid Arthritis of the Cervical

Spine: A Long-Term Analysis with Predictors of Paralysis and Recovery. J. Bone Joint Surg. 75-A:1282-1297, 1993.

30. Wiesel S.W., Boden S.D.: Pedicle finder design: A Flange to Prevent Vertebral Body Cortex

Penetration. J Orthop Tech 1(2):89-90, 1993. 31. Soghikian G.W., Boden S.D., Labropoulos P.A.: Bone Mineral Content of the Spine and Proximal

Femur in Female Patients with Hip Fracture. Orthopedics 17:917-921, 1994.

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JOURNAL ARTICLES: (Cont.) 32. Catherwood B.D., Titus L., Evans C.O., Rubin J., Boden S.D., Nanes M.S.: Increased Expression of

Tissue Plasminogen Activator Messenger RNA in an Immediate Response to Parathyroid Hormone in Neonatal Rat Osteoblasts. Endocrinology 134:1429-1436, 1994.

33. Wiesel S.W., Boden S.D., Feffer H.L.: A Quality-based Protocol for the Management of

Musculoskeletal Injuries: A Ten-Year Prospective Outcome Study. Clinical Orthopaedics and Related Research 301:164-176, 1994.

34. Wiesel S.W., Boden S.D.: Musculoskeletal Injuries in the Workplace: Defining Quality Care.

Journal of American Academy of Orthopaedic Surgeons 2:231-238, 1994. 35. Yamaguchi K., Martin C.H., Boden S.D., Labropoulos P.A.: Operative Treatment of Syndesmotic

Disruptions Without Use of a Syndesmotic Screw: A Prospective Clinical Study. Foot and Ankle 15:407-414, 1994.

36. Schimandle, J.H., Boden, S.D.: Spine Update: The Use of Animal Models to Study Spinal Fusion.

Spine, 19:1998-2006, 1994. 37. Schimandle, J.H., Boden, S.D.: Spine Update: Animal Use in Spinal Research. Spine, 19:2474-

2477, 1994. 38. Boden, S.D. Rheumatoid Arthritis of the Cervical Spine: Surgical Decision Making Based on

Predictors of Paralysis and Recovery. Spine, 19:2275-2280, 1994. 39. Boden, S.D., Martin, C., Rudolph, R., Kirkpatrick, J.S., Moeini, S.M.R., Hutton, W.C.: Increase of

Motion Between Lumbar Vertebrae After Excision of the Capsule and Cartilage of the Facets. J Bone Joint Surg, 76-A:1847-1853, 1994.

40. Boden, S.D., Schimandle, J.H., Hutton, W.C.: An Experimental Lumbar Intertransverse Process

Spinal Fusion Model: Radiographic, Histologic, and Biomechanical Healing Characteristics. Spine, 20:412-420, 1995.

41. Schimandle, J.H., Boden, S.D., Hutton, W.C.: Experimental Spinal Fusion with Recombinant

Human Bone Morphogenetic Protein 2 (rhBMP-2). Spine, 20:1326-1337, 1995. 42. Dina, T.S., Boden, S.D., Davis, D.O.: The Lumbar Spine After Surgery for Herniated Disk: Imaging

Findings in the Early Postoperative Period. American Journal of Roentgenology, 164:665-671, 1995.

43. Silcox, D.H., Daftari, T., Boden, S.D., Schimandle, J.H., Hutton, W.C. Whitesides, T.E.: The Effect

of Nicotine on Spinal Fusion. Spine, 20:1549-1553, 1995. 44. Boden, S.D., Schimandle, J.H., Hutton, W.C.: Lumbar Intertransverse Process Spinal Arthrodesis

with Use of a Bovine Bone-Derived Osteoinductive Protein: A Preliminary Report. J. Bone Joint Surg., 77-A:1404-1417, 1995.

45. Boden, S.D., Riew, K.D., Yamaguchi, K., Branch, T.P., Schellinger, D., Wiesel, S.W.: Lumbar Facet

Joint Orientation: Association With Degenerative Disc Disease. J. Bone Joint Surg., 78-A:403-411, 1996.

46. Boden, S.D., Sumner, R.: Biologic Factors Affecting Spinal Fusion and Bone Regeneration. Spine,

20:102S-112S, 1995. 47. Boden, S.D., Schimandle, J.H.: Biologic Enhancement of Spinal Fusion. Spine, 20:113S-123S,

1995. Scott D. Boden, MD July, 2011 13

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JOURNAL ARTICLES: (Cont.) 48. Riebel, G.D., Boden, S.D., Whitesides, T.E., Hutton, W.C.: The Effect of Nicotine on Incorporation

of Cancellous Bone Graft in an Animal Model. Spine, 20:2198-2202, 1995. 49. Feiertag, M.A., Boden, S.D., Schimandle, J.H., Norman, J.T.: A Rabbit Model for Nonunion of

Lumbar Intertransverse Process Spine Arthrodesis. Spine, 21:27-31, 1996. 50. Boden, S.D., Schimandle, J.H., Hutton., W.C., Chen, M.I.: The 1995 Volvo Award in Basic Sciences.

The Use of An Osteoinductive Growth Factor for Lumbar Spinal Fusion. Part I: The Biology of Spinal Fusion. Spine, 20:2626-2632, 1995.

51. Boden, S.D., Schimandle, J.H., Hutton, W.C.: The 1995 Volvo Award in Basic Sciences. The Use of

an Osteoinductive Growth Factor for Lumbar Spinal Fusion. Part II: Study of Dose, Carrier, and Species. Spine, 20:2633-2644, 1995

52. Boden, S.D.: Current Concepts Review. The Use of Radiographic Imaging Studies in the Evaluation

of Patients Who Have Degenerative Disorders of the Lumbar Spine. J Bone Joint Surg, 78-A:114-124, 1996.

53. Parker, L.M., Murrell, S.E., Boden, S.D., Horton, W.C.: The Outcome of Posterolateral Fusion in

Highly Selected Patients with Discogenic Low Back Pain. Spine, 21:1909-1917, 1996. 54. Boden, S.D., McCuaig, K., Hair, G., Racine, M., Titus, L., Wozney, J.M., Nanes, M.S.: Differential

Effects and Glucocorticoid Potentiation of Bone Morphogenetic Protein Action During Rat Osteoblast Differentiation. Endocrinology, 137:3401-3407, 1996.

55. Boden, S.D., Schimandle, J.H., Hutton, W.C., Damien, C.J., Benedict, J.J., Baranowski, C., Collier,

S.: In Vivo Evaluation of a Resorbable Osteoinductive Composite as a Graft Substitute for Lumbar Spinal Fusion. J Spinal Disord, 10:1-11, 1997.

56. Boden, S.D., Wiesel, S.W.: Lumbar Spine Imaging: Role in Clinical Decision Making. Am Acad

Orthop Surg, 4: 238-248, 1996. 57. Boden, S.D., Moskovitz, P.A., Morone, M.A., Toribitake, Y: Video-Assisted Lateral Intertransverse

Process Arthrodesis. Spine, 21:2689-2697, 1996. 58. Holliger, E.H., Trawick, R.H., Boden, S.D., Hutton, W.E.: The Morphology of the Lumbar Spine

Intertransverse Process Fusion Mass in the Rabbit Model. A Comparison Between Two Bone Graft Material: rhBMP-2 and Autograft. J Spinal Disord 9:125-128, 1996.

59. Hutton, W.C., Elmer, W.A., Boden, S.D., Horton, W.C., Carr, K.: Analysis of Chondroitin Sulfate in

Lumbar Intervertebral Disks at Two Different Stages of Degeneration as Assessed by Discogram. J Spinal Disord, 10:47-54,1997.

60. Malko, J.A., Hutton, W.C., Giacometti, A.R., Kater G., Greenfield, P., Boden, S.D., Silcox, D.H.: Do

Changes in Loading Affect the Interpretation of MRI Scans of the Lumbar Spine. J Spinal Disord 9:129-135, 1996.

61. Cahoon, S., Boden, S.D., Gould, K.G., Vailas, A.C.: Noninvasive Markers of Bone Metabolism in

the Rhesus Monkey: Normal Effects of Age and Gender. J Med Primatol, 25(5):333-338, 1996. 62. Morone, M.A., Boden, S.D.: Experimental Posterolateral Spinal Fusion with a Demineralized Bone

Matrix Gel (Grafton). Spine, 23:159-167, 1998. Scott D. Boden, MD July, 2011 14

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JOURNAL ARTICLES: (Cont.) 63. Boden, S.D., Hair, G., Titus,L., Racine, M., McCuaig, K., Wozney, J.M., Nanes, M.S.:

Glucocorticoid-induced Differentiation of Fetal Rat Calvarial Osteoblasts Is Mediated by Bone Morphogenetic Protein-6. Endocrinology, 138:2920-2828, 1997.

64. Boden, S.D., Martin, G.J., Horton, W.C., Truss, T.L., Sandhu, H.S.: Laparoscopic Anterior Spinal

Arthrodesis with rhBMP-2 in a Titanium Interbody Threaded Cage. J Spinal Disord, 11:95-101, 1998.

65. Dreyer, S.J., Boden, S.D.: Natural History of Rheumatoid Arthritis of the Cervical Spine. Clin

Orthop, 366:98-106, 1999. 66. Toribatake, Y., Hutton, W.C., Tomita, K., Boden, S.D.: Vascularization of the Fusion Mass in a

Posterolateral Intertransverse Process Fusion. Spine, 23:1149-1154, 1998. 67. Barber, J.W., Boden, S.D., Ganey, T., Hutton, W.C.: A Biomechanical Study of Lumbar Pedicle

Screws Does convergence Affect Axial Pullout Strength? J Spinal Disord, 11:215-220, 1998. 68. Boden, S.D., Dreyer, S.J., Levy, H.I.: Management of Low Back Pain: Current Assessment and

Formulation of a Blueprint for the Health Care Delivery System of the Future. PM&R Clinics of North America, 9:419-433, 1998.

69. Boden, S.D., Swanson, A.L.: An Assessment of the Early Management of Spine Problems and

Appropriateness of Diagnostic Imaging Utilization. PM&R Clinics of North America, 9:411-418, 1998.

70. Sandhu, H.S., Boden, S.D.: Biologic Enhancement of Spinal Fusion. Orthop. Clin North Am,

29:621-631, 1998. 71. Boden, S.D.: Outcome Assessment After Spine Fusion: Why and How. Orthop. Clin. North Am.,

29:717-728, 1998. 72. Boden, S.D.: The Biology of Posterolateral Lumbar Spine Fusion. Orthop. Clin. North Am., 29:603-

619, 1998. 73. Morone, M.A., Boden, S.D., Martin, G.J., Hair, G., Racine, M., Titus, L., Hutton, W.C.: Marshall R.

Urist Young Investigator Award. Gene Expression during Autograft Lumbar Spine Fusion and the Effect of Bone Morphogenetic Protein-2. Clin. Orthop., 351:252-265, 1998.

74. Boden, S.D.: Bone Repair and Enhancement Clinical Trial Design: Spine Applications.

Clin.Orthop., 355S:S336-S346, 1998. 75. Martin, G.J., Boden, S.D., Titus,L.: Recombinant Human Bone Morphogenetic Protein-2 Overcomes

the Inhibitory Effect of Ketorolac, a Non-Steroidal Anti-inflammatory Drug (NSAID) on Posterolateral Lumbar Intertransverse Process Spine Fusion. Spine, 24(21):2188-94, 1999.

76. Boden, S.D., Martin, G.J., Morone, M., Ugbo, J.L., Titus, L., Hutton, W.C.: The Use of Coralline

Hydroxyapatite with Bone Marrow, Autogenous Bone Graft, or Osteoinductive Bone Protein Extract for Posterolateral Lumbar Spine Fusion. Spine, 24:320-327, 1999.

77. Martin, G.J., Boden, S.D., Titus, L., Scarborough, N.C.: New Formulations of Demineralized Bone

Matrix as a More Effective Graft Alternative in Experimental Posterolateral Lumbar Spine Arthrodesis. Spine, 24:637-645, 1999.

Scott D. Boden, MD July, 2011 15

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JOURNAL ARTICLES: (Cont.) 78. Boden, S.D., Titus, L., Hair, G., Liu, Y., Viggeswarapu, M., Nanes, H., Baranowski, C.: 1998 Volvo

Award Winner in Basic Science Studies. Lumbar Spine Fusion by Local Gene Therapy With a cDNA Encoding a Novel Osteoinductive Protein (LMP-1). Spine, 23:2486-2492, 1998.

79. Hutton, W.C., Elmer, W.A., Boden, S.D., Hyon, S., Toribatake, Y., Tomita, K., Hair, G.A.: The Effect

of Hydrostatic Pressure on Intervertebral Disc Metabolism. Spine, 24:1507-1515, 1999. 80. Silcox, D.H., Boden, S.D., Schimandle, J.H., Johnson, P., Whitesides, T.E., Hutton, W.C.:

Reversing the Inhibitory Effect of Nicotine on Spinal Fusion Using an Osteoinductive Protein Extract. Spine, 23:291-297, 1998.

81. Chen,M.I., Boden, S.D., Ugbo, J.L., Schimandle, J.H., Hutton, W.C.: A New Semi-Automated

Method for Histologic Quantitation of Lumbar Spine Fusion Process. Neuro-Orthopedics, 24:43-57, 1998.

82. Boden, S.D., Liu, Y., Hair, G.A., Helms J.A., Hu D., Racine M., Nanes M.S., Titus L.: LMP-1, A LIM-

Domain Protein, Mediates BMP-6 Effects on Bone Formation. Endocrinology, 139(12):5125-5134, 1998.

83. Dreyer, S.J., Boden S.D.: Nonoperative Treatment of Neck and Arm Pain. Spine,

23(24):2746-2754, 1998. 84. Altman, D.A., Titus, L., Hair, G.A., Boden, S.D.: Spine Update: Molecular Biology and Spinal

Disorders: A Survey for the Clinician. Spine, 24:723-730, 1999. 85. Boden, S.D., Martin, G.J., Morone, M.A., Ugbo, J.L., Moskovitz, P.A.: Posterolateral lumbar

intertransverse process spine arthrodesis with rhBMP-2/hydroxyapatite tricalcium phosphate after laminectomy in the nonhuman primate. Spine, 24:1179-1185, 1999.

86. Martin, G.J.,Jr., Boden, S.D., Morone, M.A., Moskovitz, P.A.: Posterolateral Intertransverse Process

Spinal Arthrodesis with rhBMP-2 in a Nonhuman Primate: Important Lessons Learned Regarding Dose, Carrier, and Safety. J. Spinal Disord, 12(3)179-186, 1999.

87. Ludwig, S.C., Boden, S.D.: Osteoinductive Bone Graft Substitutes For Spinal Fusion. A Basic

Science Summary. Othop Clin of North Am, 30:635-645, 1999. 88. Boden, S.D.: Bioactive Factors For Bone Tissue Engineering. Clin Orthop, 367S:S84-S94, 1999. 89. Jacobs, I.N., Podrebarac, P., Boden, S.D., Chen, M.: Graft healing in laryngotracheal reconstruction:

an experimental rabbit model. Ann Otol Rhinol Laryngol 108:599-605, 1999. 90. Boden, S.D., Zdeblick, T.A., Sandhu, H.S., Heim, S.E.: The Use of rhBMP-2 in Interbody Fusion

Cages: Definitive Evidence of Osteoinduction in Humans. Spine 25:376-381, 2000. 91. Borenstein, D.G., O’Mara, J.W., Boden, S.D., Lauerman, W.C., Jacobson, A., Platenberg, C.,

Schellinger, D., Wiesel, S.W.: The Value of Lumbar Magnetic Resonance Imaging to Predict Low Back Pain in Asymptomatic Subjects: A 7-Year Follow-Up Study. J Bone Joint Surg, 83-A:1306-1311, 2001.

92. Theiss, S., Boden, S.D., Hair, G., Titus, L., Morone, M., Louis-Ugbo, J.: The Effect of Nicotine on

Gene Expression during Spine Fusion. Spine, 25:2588-2594, 2000. 93. Boden, S.D.: Biology of Lumbar Spine Fusion and Use of Bone Graft Substitutes: Present, Future,

and Next Generation. Tissue Engineering, 6:383-399, 2000. Scott D. Boden, MD July, 2011 16

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JOURNAL ARTICLES: (Cont.) 94. Kang, J.D., Boden, S.D.: Breakout Session 7: Spine Gene Therapy. Clin Orthop, 379S:S256-S259,

2000.

95. Gilbert, L, He X, Farmer, P., Boden, S.D., Kozlowski, M., Rubin, J. Nanes, M.S.: Inhibition of Osteoclast Differentiation by Tumor Necrosis Factor-alpha. Endocrinology 141:3956-3964, 2000.

96. Boden, S.D., Hair, G.A.., Viggeswarapu, M., Liu, Y., Titus, L.: Gene Therapy for Spine Fusion. Clin Orthop, S225-S233, 2000.

97. Ludwig, S.C., Kowalski, J.M., Boden, S.D.: Osteoinductive bone graft substitutes. Eur Spine J 9(Suppl 1):S119-S125, 2000.

98. Murakami, H., Boden,S.D., Hutton, W.C.: Anterior Lumbar Interbody Fusion Using a Barbell Shaped

Cage. J Spinal Disord , 14:385-392,2001. 99. Viggeswarapu, M., Boden, S.D., Li, Y., Hair, G.A., Louis-Ugbo, J., Murakami, H., Kim, H-S., Mayr, M.T., Hutton, W.C., Titus, L.: Adenoviral Delivery of Lim Mineralization Protein–1 Induces New Bone Formation in Vitro and In Vivo. J Bone Joint Surg 83-1:364-376, 2001. 100. Cha, C.W., Boden, S.D.: Potential of Growth Factors and Gene Therapy in Spinal Stabilization.

Seminars in Spine Surgery 13:73-81, 2001. 101. Hutton,W.C., Elmer, W.A., Bryce, L.M., Kozlowska, E.E., Boden, S.D., Koslowski, M.: Do the

Intervertebral Disc Cells Respond to Different Levels of Hydrostatic Pressure? Clinical Biomechanics, 16:728-734, 2001.

102. Levy, H.I., Hanscom, B., Boden, S.D.: Three Question Depression Screener in Lumbar Disc

Herniations and Spinal Stenosis. Spine, 27:1232-1237, 2002. 103. Liu, Y., Hair, G.A., Boden,S.D., Viggeswarapu, M., Titus, L.: Overexpressed LIM Mineralization

Proteins Do Not Require LIM Domains to Induce Bone. J Bone Min Res, 17:406-414, 2002. 104. Boden, S.D.: Overview of the Biology of Lumbar Spine Fusion and Principles for Selecting a Bone

Graft Substitute. Spine, 27S:S26-S31, 2002. 105. Suh, D.Y., Boden, S.D., Louis-Ugbo, J., Mayr, M.T., Murakami, H., Kim, H-S., Minamide, A., Hutton,

W.C.: Delivery of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) Using a Compression Resistant Matrix in Posterolateral Spine Fusion in the Rabbit and the Non-Human Primate. Spine, 27:353-360, 2002.

106. Louis-Ugbo, I., Kim, H-S., Boden, S.D., Mayr, M.T., Li, R.C., Seeherman, H., D’Augusta, D., Blake,

C., Jiao, A., Peckham,S.: Retention of 125I-Labeled Recombinant Human Bone Morphogenetic Protein-Z By Biphasic Calcium Phosphate or a Composite Sponge in a Rabbit Posterolateral Spine Arthrodesis Model. J. Orthop. Res., 20:1050-1059, 2002.

107. Boden, S.D., Kang, J., Sandhu, H., Heller, J.G.: 2002 Volvo Award in Clinical Studies. Use of

rhBMP-2 to Achieve Posterolateral Lumbar Spine Fusion in Humans: A Prospective and Randomized Clinical Pilot Trial. Spine, 27:2662-2673, 2002.

108. Zigler, J.E., Boden, S.D., Anderson, P.A., Bridwell, K., Vaccaro, A.: Specialty Update: What’s New

in Spine Surgery. J. Bone Joint Surg., 84-A:1282-1288, 2002. Scott D. Boden, MD July, 2011 17

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JOURNAL ARTICLES: (Cont.)

109. Greenwald AS, Boden SD, Goldberg VM, Khan Y, Laurencin CT, Rosier RN: Bone-Graft Substitutes: Facts, Fictions, And Applications. J Bone Joint Surg Am 83-A (Suppl 2, Pt 2):98-103, 2001.

110. Akamaru, T., Suh, D.Y., Boden, S.D., Kim, H-S., Minamide, A., Louis-Ugbo, J.: Simple Carrier Matrix Modifications Can Enhance Delivery of Recombinant Human Bone Morphogenetic Protein-2 for Posterolateral Spine Fusion. Spine, 28(5):429-434, 2003.

111. Damien, C.J., Grob, D., Boden, S.D., Benedict, J.J. : Purified Bovine BMP Extract and Collagen for

Spine Arthrodesis : Preclinical Safety and Efficacy. Spine, 27S:S50-S58, 2002. 112. Minamide, A., Boden, S.D., Viggeswarapu, M., Hair, G., Oliver, C., Titus, L.: Mechanism of Bone

Formation With Gene Transfer of the cDNA Encoding for the Intracellular Protein LMP-1: Evidence for Induction of Multiple BMPs. J. Bone Joint Surg., 86-A(6):1030-1039, 2003.

113. Yoon ST, Boden SD: Osteoinductive Molecules In Orthopaedics: Basic Science And Preclinical

Studies. Clin Orthop 395:33-43, 2002.

114. Schaufele, M.K., Boden, S.D.: Outcome Research in Patients with Chronic Low Back Pain. Orthop. Clin. 34:231-237, 2003.

115. Kim, H-S., Viggeswarapu, M., Boden, S.D. Liu, Y., Hair, G., Louis-Ugbo, J., Murakami, H.,

Minamide, A., Suh D.Y., Titus, L.: Overcoming the Immune Response to Permit Ex Vivo Gene Therapy for Spine Fusion With Type 5 Adenoviral Delivery of the LIM Mineralization Protein-1 (LMP-1) cDNA. Spine, 28(3):219-226, 2003.

116. Boden, S.D., Grob, D., Damien, C.: Ne-Osteo Bone Growth Factor for Posterolateral Lumbar Spine

Fusion. Spine, 29:504-514, 2004 117. Pahl, M.A., Brislin, B.T., Boden,S.D., Hilibrand, A.S., Vaccaro, A.R., Hanscom, B., Albert, T.J.: The

Impact of Four Common Lumbar Spine Diagnoses Upon Overall Health Status. The Spine Journal, 6:125-130, 2006

118. Schaufele, MK, Boden, SD: Physical function measurements in neck pain. Phys Med Clin N AM 14:569-588, 2003. 119. Dreyer, SJ, Boden, SD: Laboratory evaluation in neck pain. Phys Med Clin N AM 14:589-604,

2003. 120. Schaufele, MK, Boden, SD: Outcome research in patients with chronic low back pain. Orthop Clin

N Am 34:231-237, 2003. 121. Carey, TS, Boden, SD: A critical guide to case series reports. Spine 28:1631-1634, 2003. 122. Weinstein, JN, Boden, SD, An,H: Editorial: Emerging technology in Spine. Should we rethink the

past or move forward in spite of the past? Spine 28(15S):S1, 2003. 123. Cha, CW, Boden, SD: Gene Therapy applications for spine fusion. Spine 28(15S): S74-S84, 2003. 124. Zigler, JE, Anderson, PA, Boden, SD, Birdwell KH, Vaccaro, AR: Specialty Update: What’s new in

spine surgery. J Bone Joint Surg 85A:1626-1636, 2003. 125. Louis-Ugbo, J, Murakami, H, Kim, H-S, Minamide, A, Boden, SD: Evidence of osteoinduction by

Grafton Demineralized Bone Matrix in Non-human primate spinal fusion. Spine 29: 360-366, 2004. Scott D. Boden, MD July, 2011 18

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JOURNAL ARTICLES: (Cont.) 126. Yoon, ST, Boden, SD: Spine fusion by gene therapy. Gene Therapy, 11:360-367, 2004. 127. Boden, SD, Balderston, RA, Heller, JG, Hanley, Jr, EN, Zigler, JE: An AOA Critical Issue: Disc

Replacements: This time will we really cure low-back and neck pain? J Bone Joint Surg 86A:411-422, 2004.

128. Tortolani, PJ, Park, AE, Louis-Ugbo, J, Attalah-Wasif, E, Kraiwattanapong C, Heller, JG, Boden,

SD, Yoon ST: The effects of doxorubicin (adriamycin) on spinal fusion: An experimental model of posterolateral lumbar spinal arthrodesis. Spine J., 4:669 – 674, 2004.

129. Yoon, ST, Park JS, Kim KS, Li J, Attalah-Wasif, ES, Hutton, WC, Boden, SD: ISSLS Prize Winner:

LMP-1 upregulates Intervertebral disc cell production of Proteoglycans and BMPs in vitro and in vivo. Spine, 29: 2603-2611, 2004.

130. Liu, Y, Titus, L Barghouthi, M, Viggeswarapu, M, Hair, G, Boden, S: Gluocorticoid regulation of

human BMP-6 transcription. Bone 35: 673-681, 2004. 131. Bridwell, K, Anderson, PA, Boden, SD, Vacarro, AR, Zigler, JE: What’s new in spine surgery. J

Bone Joint Surgery 86-A: 1587-1596, 2004. 132. Barnes, B, Boden, SD, Louis-Ugbo, J, Tomak, PR, Park, JS, Park MS, Minamide, A: Lower dose of rhBMP-2 achieves spine fusion when combined with an osteoconductive bulking agent in

non-human primates. Spine, 30(10): 1127-1133, 2005. 133. Kraiwattanapong, C, Boden, SD, Louis-Ugbo, J Attallah-Wasif, E, Barnes, B, Hutton, W:

Comparison of healos/bone marrow to Infuse (rhBMP-2/ACS) with a collagen-ceramic sponge bulking agent as graft substitutes for lumbar spine fusion. Spine, 30(10): 1001-1007, 2005.

134. Boden, SD, Einhorn, TA, Morgan, TS, Tosi LL, Weinstein, JN: An AOA Critical Issue. The Future of the Orthopaedic Surgeon: Proceduralist or Keeper of the Musculoskeletal System: J Bone Joint Surgery, 87-A: 2812-2821, 2005. 135. Boden, SD: The ABC’s of BMPs. Ortho Nurs, 24: 49-52, 2005. 136. Minamide, A, Yoshida, M, Kawakami, M, Yamasaki, S, Kojima, H, Hashizume, H, Boden, SD: The

use of cultured bone marrow cells in Type I collagen gel and porous hydroxyapatite for posterolateral lumbar spine fusion. Spine, 30: 1134-1138, 2005.

137. Bridwell, KH, Anderson, PA, Boden, SD, Vaccaro, AR, Wang, JC: What’s new in spine surgery. J

Bone Joint Surg, 87-A: 1892-1901, 2005. 138. Singh, K, Smucker, JD, Boden, SD: Use of recombinant bone morphogenetic protein – 2

as an adjunct in posterolateral lumbar spine fusion: A prospective CT-scan analysis at one and two years. J Spinal Disord, 19:416-423, 2006.

139. Zanella, JM, Oliver, C, Peckham, SM, McKay, B, Toth, JM, Boden, SD: Effect on bone induction of using contrast media to reconstitute recombinant human bone morphogenetic protein – 2 in an ectopic model in rats: J Neurosurg Spine 5:434-439, 2006. 140. Weinstein, JN, Tosteson, TD, Lurie, JD, Tosteson, AN, Hanscom, B, Skinner, JS, Abdu, WA, Hilibrand, AS, Boden, SD, Deyo, RA: Surgical vs nonoperative treatment for lumbar disk herniation. The spine patient outcomes research trial (SPORT): A randomized trial. JAMA 296: 2441-2450, 2006. Scott D. Boden, MD July, 2011 19

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JOURNAL ARTICLES: (Cont.) 141. Sangadala S, Boden SD, Viggeswarapu M, Liu Y, Titus L: LIM Mineralization Protein – 1 potentiates bone morphogenetic protein responsiveness by a novel interaction with Smurf1 resulting in decreased ubiquitination of smads. J Biol Chem 281:17212 – 17219, 2006. 142. Minamide A, Yoshida M, Kawakani M, Enyo Y, Hashizume H, Boden SD: The effects of Bone morphogenetic protein and basic fibroblast growth factor on cultured mesenchymal stem cells for spine fusion. Spine 32: 1067-1071, 2007. 143. Singh K, Smucker JD, Ugbo JL, Tortolani PJ, Tsai L, Fei Q, Kuh S, Rumi M, Heller JG, Boden SD, Yoon St: rhBMP-2 enhancement of posterolateral spine fusion in a rabbit model in the presence of concurrently administered doxorubicin. Spine J. 3:326-331, 2007. 144. Yaszemski MJ, Polly DW, Boden SD, Anderson GB: Technology assessment: approach and reimbursement. Spine 32:S39-43, 2007. 145. Sangadala S, Boden SD, Metpally RP, Reddy BV: Modeling and analysis of molecular interaction between Smurf1-WW2 domain and various isoforms of LIM mineralization protein. Proteins 68:690- 701, 2007. 146. Obremskey, WT, Marotta JS, Yaszemski MJ, Churchill LR, Boden SD, Dirschl DR: Symposium.

The introduction of biologics in orthopaedics: issues of cost, commercialization, and ethics. J Bone Joint Surg 89, 1641-1649, 2007.

147. Glassman SD, Dimar JR, Burkus K, Hardacker JW, Pryor PW, Boden SD, Carreon LY: The efficacy of rhBMP-2 for posterolateral lumbar fusion in smokers. Spine 32:1693-1698, 2007. 148. Fei Q, Boden SD, Sangadala S, Viggeswarapu M, Liu Y, Titus L: Truncated human LMP-1 triggers

differentiation of C2C12 cells to an osteoblastic phenotype in vitro. Acta Biochim Biophys Sin, 39:693-700, 2007.

149. Hilibrand AS, Spindler KP, Boden SD: AOA Symposium. Orthopaedists partnering with other physicians to provide musculoskeletal care. J Bone Joint Surg 89:2810-2818, 2007. 150. Weinstein JN, Tosteson TD, Lurie JD, Tosteson AN, Blood E, Hanscom B, Herkowitz H, Cammisa F,

Albert T, Boden SD, Hilibrand A, Goldberg H, Berven S, An H: Surgical versus nonsurgical therapy for lumbar spinal stenosis. N Engl J Med 358:794-810, 2008.

151. Bridwell KH, Anderson PA, Boden SD, Vaccaro AR, Wang JC: What’s new in spine surgery. J Bone

Joint Surg Am 90:1609-1619, 2008. 152. Sangadala S, Titus L, Boden SD: Expression, purification and mass spectrometric analysis of LIM

mineralization protein-1 in human lung epithelial cells. Acta Biochim Biophys Sin 40:909-918, 2008. 153. Tosteson AN, Lurie JD, Tosteson TD, Skinner JS, Herkowitz H, Albert T, Boden SD, Bridwell K,

Longley M, Andersson GB, Blood EA, Grove MR, Weinstein JN: Surgical treatment of spinal stenosis with and without degenerative spondylolisthesis: cost-effectiveness after 2 years. Ann Intern Med 149:845-853, 2008.

154. Toth JM, Boden SD, Burkus JK, Badura JM, Peckham SM, McKay WF: Short-term osteoclastic

activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment. Spine 34:539-550, 2009.

155. Boden LM, Rosengren KJ, Martin DF, Boden SD: A comparison of static near stereo acuity in youth

baseball/softball players and non-ball players. Optometry 80:121-125, 2009. Scott D. Boden, MD July, 2011 20

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JOURNAL ARTICLES: (Cont.) 156. Sangadala S, Okada M, Liu Y, Viggeswarapu M, Titus L, Boden SD: Engineering, cloning and

functional characterization of recombinant LIM mineralization protein-1 containing an N-terminal HIV-derived membrane transduction domain. Protein Expr Purif 65:165-173, 2009.

157. Bridwell KH, Anderson PA, Boden SD, Vaccaro AR, Wang JC: What’s new in spine surgery. J

Bone Joint Surg Am 91:1822-1834, 2009. 158. Abdu WA, Lurie JD, Spratt KR, Tosteson AN, Zhao W, Tosteson TD, Herkowitz H, Longely M,

Boden SD, Emery S, Weinstein JN: Degenerative spondylolisthesis: Does fusion method influence outcome? Four-year results of the spine patient outcomes research trial. Spine 34:2351-2360, 2009.

159. Okada M, Sangadala S, Liu Y, Yoshida M, Reddy BV, Titus L, Boden SD: Development and

optimization of a cell-based assay for the selection of synthetic compounts that potentiate bone morphogenetic protein-2 activity. Cell Biochem Funct 27:526-534, 2009.

160. Liu H, Bargouti M, Zughaier S, Zheng Z, Liu Y, Sangadala S, Boden SD, Titus L: Osteoinductive

LIM mineralization protein-1 supresses activation of NF-kappaB and selectively regulates MAPK pathways in pre-osteoclasts. Bone 46:1328-1335,. 2009.

161. Bridwell KH, Anderson PA, Boden SD, Vaccaro AR, Wang JC: What’s new in spine surgery. J Bone

Joint Surg Am 92:2017-2028, 2010. 162. Boden SD: 2009 ISSLS Presidential Address: the three key questions. Spine 35:1048-1053, 2010. 163. Weinstein JN, Tosteson TD, Lurie JD, Tosteson A, Blood E, Herkowitz H, Cammisa F, Albert T,

Boden SD, Hillibrand A, Goldberg H, Berven S, An H: Surgical versus nonoperative tereatment for lumbar spinal stenosis four-year results of the Spine Patient Outcomes Research Trial. Spine 35:1329-1338, 2010.

164. Higashino K, Viggeswarapu M, Bargouti M, Liu H, Titus L, Boden SD: Stromal cell-derived factor-1

potentiates bone morphogenetic protein-2 induced bone formation. Tissue Eng Part A 17:523-530, 2011.

165. Liu H, Liu Y, Viggeswarapu M, Zheng Z, Titus L, Boden SD: Activation of c-Jun NH(2)-terminal

kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type I BMP receptor. J Bone Miner Res 26:1122-1132, 2011.

166. Kato S, Sangadala S, Tomita K, Titus L, Boden SD: A synthetic compound that potentiates bone

morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype. Mol Cell Biochem 349:97-106, 2011.

167. Nakao SI, Minamide A, Kawakami M, Boden SD, Yoshida M: The influence of alendronate on spine

fusion in an osteoporotic animal model. Spine 36:1445-52, 2011. 168. Liu H, Liu Y, Viggeswarapu M,Zheng Z, Titus L, Boden SD (2011) Activation of c-Jun HN(2) terminal

kinase-1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor. J Bone Min Res 26(5)1122-32

169. Kato S, Sangadala S, Tomita K, Titus L, Boden SD (2011) A synthetic comound that potentiates

bone morphogenetic protein-2 induced transdifferentiation of myoblasts into the osteoblastic phenotype. Mol Cell Biochem 349(1-2)97-106

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170 Liu Y, Liu H, Titus L, Boden SD (2012) Natural antisense transcripts enhance bone formation by increasing sense IFITM5 transcription. Bone 51(5)933-8

BOOKS : 1. Boden, S.D., Wiesel, S.W., Laws, E.R., Rothman, R.H.: The Aging Spine: Essentials of Path

physiology, Diagnosis and Management. Philadelphia: W.B. Saunders Co., 350 pp., 140 illus., 19 chapters, February 1991.

2. Wiesel, S.W., Boden, S.D., Borenstein, DG, Rothman, R.H.: Neck Pain, 2nd Ed. Charlottesville:

The Michael Co., 490 pp., 1992. 3. Borenstein, D.G., Wiesel, S.W., Boden, S.D.: Low Back Pain: Medical Diagnosis and

Comprehensive Management. 2nd Ed. Philadelphia: W. B. Saunders Co., 1995. 4. Borenstein, D.G., Wiesel, S.W., Boden, S.D.: Neck Pain: Medical Diagnosis and Comprehensive

Management. Philadelphia: W.B. Saunders Co., 1996. 5. Schering, S.C., Boden, S.D., Borenstein, D.G., Wiesel, S.W.: Neck Pain. 3rd Ed. Charlottesville:

Lexis Publishing, 2000. 6. Emery, S.E., Boden, S.D.: Surgery of the Cervical Spine. Philadelphia: Saunders, 2003. 7. Boden, S.D., Bohlman, H.H.: The Failed Spine. Philadelphia, Lippincott Williams & Williams, 2003. 8. Corbin, T., Connolly, P., Yuan, H., Bao, C., Boden, SD: Emerging Spine Surgery Technologies. St.

Louis: Quality Medical Publishing, 2005. 9. Borenstein, D.G., Wiesel, S.W., Boden, S.D.: Low Back and Neck Pain: Comprehensive Diagnosis

and Management. Philadelphia: W.B. Saunders Co., 2004.

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BOOK CHAPTERS: 1. Boden, S.D., and Wiesel, S.W.: Standardized Approaches to Diagnosis and Treatment of Low Back

Pain and Multiply Operated Patients. In Low Back Pain, Eds. S.W. Wiesel et al. Charlottesville: Michie Co., 1989, pp. 95-174.

2. Bolander, M.E., Joyce, M.E., Boden, S.D., Oliver, B., and Heydemann, A.: Estrogen Receptor

MRNA Expression During Fracture Healing in the Rat Detected by Polymerase Chain Reaction Amplification. In Calcium Regulation and Bone Metabolism, Ed. by D.V. Cohn, F.H. Glorieux, and T.J. Martin. Amsterdam: Elsevier Science Publishers, 1990, pp. 382-387.

3. Boden, S.D., and Wiesel, S.W.: Chronic Low Back Pain: Avoiding Common Diagnostic and

Therapeutic Errors. In Evaluation and Treatment of Chronic Pain, 2nd ed., Ed. G.M. Arnoff. Baltimore: Williams & Wilkins, 1992, pp.238-247.

4. Kaplan, F.S., Boden, S.D., and Zackai, E.: Skeletal Dysplasia and Dwarfism: Physiology and Path

physiology. In Neonatology Fetal Medicine, Physiology and Pathophysiology, Ed. R.A. Polin and W.W. Fox.. Philadelphia: W.B. Saunders, 1992, pp. 1656-1665.

5. Boden, S.D., and Wiesel, S.W.: Conservative Treatment of Cervical Disc disease. In Rothman and

Simeone's The Spine, 3rd Ed.. Philadelphia: W.B. Saunders, 1992, pp 591-596. 6. Boden, S.D., and Wiesel, S.W.: Compensation Low Back and Neck Pain. In Rothman and

Simeone's The Spine, 3rd Ed.. Philadelphia: W.B. Saunders, 1992, pp 1909-1920. 7. Boden, S.D., and Wiesel, S.W.: The Multiply Operated Low Back Patient. In Rothman and

Simeone's The Spine, 3rd Ed.. Philadelphia: W.B. Saunders, 1992, pp 1899-1906. 8. Boden, S.D., and Wiesel, S.W.: Conservative Management of Cervical Disc Disease. In Disorders

of the Cervical Spine, ed. by M.B. Camins and P.F. O'Leary. Baltimore: Williams & Wilkins, 1992, pp 157-160.

9. Wiesel, S.W., and Boden, S.D.: Conservative Treatment of Spinal Stenosis: The Cornerstone. In

Spinal Stenosis, Ed. by G.B. Anderson. Mosby Year Book, 1992, pp 331-338. 10. Boden, S.D., Wiesel, S.W.: Standardized Approach to the Diagnosis and Treatment of Neck Pain

and Brachialgia. In Neck Pain, Ed. by S.W. Wiesel et al. Charlottesville: The Michie Co., 1992, pp. 75-108.

11. Boden, S.D., Bohlman, H.H.: Orthopaedic Management of the Spine in Rheumatic Disease. In

Rheumatology, Ed. by J. Klippel and P. Dieppe. London: Mosby-Year Book Europe, 1994, pp 271-278.

12. Boden, S.D., Bohlman, H.H.: Rheumatoid Arthritis of the Cervical Spine: Surgical Decision-Making.

In Surgery of the Cervical Spine, Ed. by H.S. An and J.M. Simpson. London: Martin Dunitz, 1995, pp. 357-366.

13. Boden, S.D., Clark, C.R.: Rheumatoid Arthritis of the Cervical Spine: Predictors of Paralysis and

Recovery. In The Cervical Spine, Ed. by C.R. Clark. Philadelphia: Lippincott, 1998, pp. 693-703. 14. Boden, S.D.: Diagnostic Imaging of the Spine. In Essentials of the Spine, Ed. by J.N. Weinstein, B.

Rydevik, V. Sonntag. New York: Raven Press, 1995, pp. 97-110.

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15. Wiesel, S.W., Boden, S.D.: Diagnosis and Management of Cervical and Lumbar Disease. In Essentials of the Spine, Ed. by J.N. Weinstein, B. Rydevik, V. Sonntag. New York: Raven Press, 1995, pp. 139-163.

16. Boden, S.D., Schimandle, J.H.: The Biology of Lumbar Spine Fusion and Bone Graft Materials. In

The Lumbar Spine, 2nd Ed., Ed. by S.W. Wiesel, J.N. Weinstein, H.N. Herkowitz et al. Philadelphia: W.B. Saunders, 1996, pp 1284-1306.

17. Boden, S.D., Wiesel, S.W., Spengler, D.M.: A Lumbar Spine Algorithm. In The Lumbar Spine, 2nd

Ed., Ed. by S.W. Wiesel, J.N. Weinstein, H.N. Herkowitz et al. Philadelphia: W.B. Saunders, 1996, pp. 447-457.

18. Wiesel, S.W., Eisenstein, S., Delamarter, R., Dove J., Boden, S.D.: The Multiply Operated Lumbar

Spine. In The Lumbar Spine, 2nd Ed., Ed. by S.W. Wiesel, J.N. Weinstein, H.N. Herkowitz et al. Philadelphia: W.B. Saunders, 1995, pp 1106-1117.

19. Boden, S.D., Lee, R.R., Herzog, R.J.: Magnetic Resonance Imaging of the Spine. In The Adult

Spine, 2nd Ed. Ed. by J. Frymoyer et al. New York: Raven Press, 1997, pp. 563-630. 20. Boden, S.D., Frymoyer, J.: Segmental Instability: Overview and Classification. In The Adult Spine,

2nd Ed. Ed. by J. Frymoyer et al. New York: Raven Press, 1997, pp. 2137-2156. 21. Levine, M.J., Boden, S.D.: Current Opinion in Orthopaedics: Allograft and Bone Substitutes for the

Spine. Current Opin Orthop, 7:41-47, 1996. 22. Levine, M.J., Boden, S.D.: Diagnostic Imaging of the Spine. In Principles and Techniques of Spine

Surgery, Ed. by H.S. An. Philadelphia: William & Wilkins, 1998, pp. 103-127. 23. Boden, S.D.: Bone Growth Enhancing Substance for Spinal Fusion. In Orthopedic Knowledge

Update - Spine, Ed. by S. R. Garfin and A.R. Vaccaro. Rosemont, IL: AAOS, 1996, pp. 63-67. 24. Boden, S.D., Wiesel, S.W.: Compensation Low Back and Neck Pain. In The Spine, 4th Ed., Ed. by

H. Herkowitz et al. Philadelphia, W.B. Saunders, 1999, pp.1773-1782. 25. Schimandle, J.H., Boden, S.D.: Bone Grafts and Bone Graft Substitutes for Spinal Fusion. In The

Spine, 4th Ed., Ed. by H. Herkowitz et al. Philadelphia, W.B. Saunders, 1999, pp 1610-1630. 26. Boden, S.D.: Imaging of the Patient With Lumbar Radiculopathy. In Low Back Pain: A Scientific

and Clinical Overview, Ed. by J.N. Weinstein and S.L. Gordon. Rosemont, IL: AAOS, 1997, pp. 73-83.

27. Schimandle, J.H., Boden, S.D.: Bone Substitutes for Lumbar Fusion: Present and Future.

Operative Tech. Orthop., 7:60-67, 1997. 28. Lamb, D., Boden, S.D.: Imaging of the Post-Operative Spine Patient: An Algorithmic Approach. In

Revisions in Spine Surgery, Ed. by J.Y. Margulies, M. Aebi, and C.F. Jean-Pierre. Philadelphia: Mosby, 1999, Ch. 14, pp. 188-200.

29. Boden, S.D.: Rheumatoid Arthritis: Atlantoaxial Instability Management Algorithm. In

Controversies in Spine Surgery, Ed. by T.A. Zdeblick et al. St. Louis, Quality Medical Publishing, 1999, Ch. 12, pp. 315-320.

30. Buckwalter, J.A., Boden, S.D., Eyre, D.R., Mow, V.C., Weidenbaum, M.: Intervertebral Disc: Aging,

Degeneration, and Herniation. In Orthopaedic Basic Science, 2nd Ed., ed. by Joseph A. Buckwalter, T.A. Einhorn and S.R. Simon. Rosemont, IL: AAOS, 2000, Ch. 22, pp. 557-566.

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31. Boden, S.D., Reiter, M.F., Simpson, J.M.: Inflammatory arthritis of the Spine. In Orthopaedic Knowledge Update: Home Study Syllabus, ed. by J.H. Beaty. [Rosemont, IL], American Academy of Orthopaedic Surgeons, 1999, Ch. 56., pp. 737-746.

32. Wiesel, S.W., Boden, S.D., Lauerman, E.C.: The Multiply Operated Low Back: An Algorithmic

Approach. In The Spine, 4th Ed., ed. by H. Herkowitz et al. Philadelphia, W.B. Saunders, 1999, pp. 1741-1748.

33. Boatright, K.C., Boden, S.D.: Bone Graft and Fusion-Enhancing Substances: Practical Applications

of Gene Therapy. In Principles and Practice of Spine Surgery, ed. by A.R. Vaccaro, R.R., Betz, and S.M. Zeidman. St. Louis: Mosby, 2002, pp. 127-139.

34. Schimandle, J.H., Boden, S.D.: Cervical Radiculopathy. In Surgery of the Cervical Spine, ed. By

S.E. Emery and S.D. Boden. Philadelphia: W.B. Saunders, 2003, pp. 89-111. 35. Dreyer, S.J., Boden, S.D.: Cervical Spine. Nonoperative Treatment. In The Failed Spine, ed. by

S.D. Boden and H.H. Bohlman. Philadelphia: Lippincott Williams & Wilkens, 2003, pp. 18-29. 36. Boden, S.D.: Gene Therapy: Augmentation of Bone Formation for Spine Fusion. In Molecular

Biology in Orthopaedics, ed. By C. Evans. Rosemont, IL: AAOS, 2003, Ch. 31, pp. 387-401. 37. Boden, S.D.: Clinical Trials in Bone Tissue Engineering: General Design Principles. In

Orthopaedic Tissue Engineering, ed. By L. Sandell and A. Grodzinsky. Rosemont, IL: AAOS, 2004. 38. Boden, S.D.: Clinical Trials in Bone Tissue Engineering: Spine Applications Update. In

Orthopaedic Tissue Engineering, ed. By L. Sandell and A. Grodzinsky. Rosemont, IL: AAOS, 2004, Ch 14.

39. Cha, CW, Boden, SD: Gene Therapy Approaches to Spine Fusion. In Emerging Spinal

Technologies, ed. By T. Corbin, P. Connolly, H. Yuan, C. Bao, S.D. Boden. St. Louis: Quality Medical Publishing, 2005, Ch 8, PP 111-125.

40. Rhee, JM, Boden, SD: Opportunities in Spinal Applications. In Bone Tissue Engineering, ed by J.O. Hollinger, T.A., Einhorn, B.A. Doll, C. Sfeir. Boca Raton: CRC Press, 2005, pp 315-329. 41. Boatright, KC, Boden, SD: Biology of Spine Fusion. In Bone regeneration and repair ed by JR Lieberman and GE Friedlaender, Totowa, NJ Humana Press, 2005, Ch 12, PP 225-239. 42. Hollinger JO, Schnitz JP, Friedlaender GE, Brown CR, Boden SD, Lynch S: Therapeutic

Opportunities fo rBone Grafting. In Principles of Regenerative Medicine, ed by A Atala, R Lanze, JA Thomson, RM Nerem. Burlington MA. Elsevier, 2008, Ch 68, pp 1164-1175.

AUDIO JOURNALS: 1. Abnormal Lumbar MRI Scans in Asymptomatic Subjects. Orthopaedic Audio Synopsis, July 1990. 2. Abnormal Cervical MRI Scans in Asymptomatic Subjects. Orthopaedic Audio Synopsis, May 1991. 3. MRI in the Diagnosis of Intra articular Knee Pathology. Orthopaedic Audio Synopsis, June, 1992. 4. Protocol for Management of Low Back Pain and Sciatica. Orthopaedic Audio Synopsis, August,

1993.

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ORAL AND POSTER PRESENTATIONS (National, Regional): 1. "Percutaneous Aspiration of Wound Hematoma After Total Hip Arthroplasty." Presented at the 54th

Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, January 1987. 2. "Estrogen Receptors in Osteoblasts in a Disorder of Trabecular Bone Remodeling." Presented at

the 34th Annual Meeting of the Orthopaedic Research Society, Atlanta, February 1-4, 1988. 3. "Quantitative CT Studies for Osteoporosis Without the Use of an External Calibration Phantom."

Presented at the Ninth Conference on Computer Applications in Radiology, Hilton Head, S.C., June 2, 1988.

4. "Mechanical Indications for the Syndesmosis Screw: A Cadaver Study." Presented at the 19th

Annual Meeting of the Eastern Orthopaedic Association, San Juan, P.R., October 13, 1988. 5. "Lumbosacral Segmental Motion in Normal Individuals." Presented at the 35th Annual Meeting of

the Orthopaedic Research Society, Las Vegas, February 6-9,1989. 6. "Hip Fracture in Young Patients: Is This Early Osteoporosis?" Presented at the 35th Annual

Meeting of the Orthopaedic Research Society, Las Vegas, February 6-9, 1989. 7. "Mechanical Indications for the Syndesmosis Screw: A Cadaver Study." Poster Presentation at the

35th Annual Meeting of the Orthopaedic Research Society, Las Vegas, February 6-9, 1989. 8. "Proximal Femoral Focal Deficiency: Evidence for a Hypertrophic Chondrocyte Defect." Poster

Presentation at the 35th Annual Meeting of the Orthopaedic Research Society, Las Vegas, February 6-9, 1989.

9. "Mechanical Indications for the Syndesmosis Screw: A Cadaver Study." Presented at the 56th

Annual Meeting of the American Academy of Orthopaedic Surgeons, Las Vegas, February 11, 1989. * Also AAOS Poster Session

10. "Hip Fractures in Young Patients: Is This Early Osteoporosis?" Presented at the American

Orthopaedic Association Residents Conference, Rochester, New York, March 1989. 11. "Abnormal Lumbar Spine MRI Scans in Asymptomatic Individuals" Presented at the Annual Meeting

of the International Society for the Study of the Lumbar Spine, Kyoto, Japan, May 19, 1989. 12. "Lumbosacral Segmental Motion in Normal Individuals." Presented at the 4th Annual Meeting of the

North American Spine Society, Quebec City, June 1989. 13. "Mechanical Indications for the Syndesmosis Screw: A Cadaver Study." Presented at the Annual

Meeting of the American Orthopaedic Foot and Ankle Society, Sun Valley, Idaho, August 3, 1989. 14. "Long-Term Precision of QCT Bone Density Measurements in Osteopenic Vertebral Specimens."

Poster Presentation at the Seventh International Workshop On Bone Densitometry, Rancho Mirage CA, September 1989.

15 "QCT Trabecular Bone Mineral Density in Young Patients With Hip Fractures." Presented at the

Seventh International Workshop On Bone Densitometry, Rancho Mirage CA, September 1989. 16. "QCT Bone Densitometry: A New Method Without the Use of an External Calibration Phantom."

Presented at the Seventh International Workshop on Bone Densitometry, Rancho Mirage CA, September 1989.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 17. "The Incidence of Abnormal Lumbar Spine MRI Scans in Asymptomatic Patients: A Prospective and

Blinded Investigation." Presented at the Southern Medical Association 83rd Annual Scientific Assembly, Washington DC, November 4, 1989.

18. "Mechanical Indications for the Syndesmosis Screw." Presented at the Southern Medical

Association 83rd Annual Scientific Assembly, Washington DC, November 4, 1989. 19. "The Incidence of Abnormal Cervical Spine MR Scans in Asymptomatic Individuals; A Prospective

and Blinded Investigation." Presented at the 17th Annual Meeting of the Cervical Spine Research Society, New Orleans LA, December 7, 1989.

20. "Estrogen Receptor MRNA Expression in Callus During Fracture Healing in the Rat." Presented at

the 36th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, February 5, 1990. 21 "Estrogen Receptors in Non-Neoplastic Skeletal Tissues." Presented by B. Monaghan at the 36th

Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, February 5, 1990. 22. "Bone Mineral Content of the Spine and Proximal Femur in Patients with Hip Fracture: A

Prospective Investigation Using QCT and DPA." Presented by G. Soghikian at the 36th Annual Meeting of the Orthopaedic Research Society, New Orleans LA, February 6, 1990.

23. "Long Term Precision of Quantitative Computed Tomography Bone Density Measurements in

Osteopenic Vertebral Specimens." Poster presentation at the 36th Annual Meeting of the Orthopaedic Research Society, New Orleans LA, February 5-8, 1990.

24. "The Incidence of Abnormal Lumbar Spine MRI Scans in Asymptomatic Subjects: A Prospective

and Blinded Investigation." Presented at the 36th Annual Meeting of the Orthopaedic Research Society and the 57th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, February 1990.

25. "QCT Bone Densitometry: A New Method With Improved Precision Without the Use of An External

Calibration Phantom." Poster presentation at the 36th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, February 5-8, 1990.

26. "Pitfalls in Diagnostic Imaging of Lumbar Degenerative Disc Disease." Scientific Exhibit at the 57th

Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans LA, February 8-13, 1990.

27. "MRI of the Acutely Injured Knee: Sensitive, But Is It Cost Effective?" Presented by P. Labropoulos

at the 57th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA, February 10, 1990.

28. "Mechanical Considerations for the Syndesmosis Screw: A Cadaver Study." Invited paper,

presented at the 7th Annual Meeting of the Southern Orthopaedic Association, Maui HA, June 9, 1990.

29. "Distinguishing Symptomatic From Asymptomatic HNP on Lumbar Spine MRI Scans." Presented at

the 103rd Annual Meeting of the American Orthopaedic Association, Boston MA, June 12, 1990. 30. "Distinguishing Symptomatic from Asymptomatic HNP on Lumbar Spine MRI Scans." Presented at

the Annual Meeting of the International Society for Study of the Lumbar Spine, Boston MA, June 14, 1990.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 31. "The Incidence of Abnormal Cervical Spine MRI Scans in Asymptomatic Subjects." Presented at the

5th Annual Meeting of the North American Spine Society, Monterey CA, August 10, 1990. 32. "The Incidence of Abnormal Magnetic Resonance Scans of the Knee in Asymptomatic Subjects."

Presented at the 21st Meeting of the Eastern Orthopaedic Association, Bermuda, October 19, 1990. 33. "The Incidence of Abnormal Magnetic Resonance Scans of the Knee in Asymptomatic Subjects."

Presented at the 58th Annual Meeting of the American Academy of Orthopaedic Surgeons, Anaheim CA, March 8, 1991. *Also presented as poster exhibit.

34. "The Incidence of Abnormal Magnetic Resonance Scans of the Knee in Asymptomatic Subjects."

Poster presentation at the 37th Annual Meeting of the Orthopaedic Research Society, Anaheim CA, March 4-7, 1991.

35. "The Incidence of Abnormal Cervical Spine MRI Scans in Asymptomatic Subjects." Invited paper,

presented at Specialty Society Day, Federation of Spine Associations, Anaheim CA, March 10, 1991.

36. "Lumbar Spine: A Prospective Study of Postoperative MR Imaging with Gd-DTPA in Asymptomatic

Patients." Presented by S.W. Wiesel at the 18th Annual Meeting of the International Society for Study of the Lumbar Spine, Heidelberg, Germany, May 13, 1991.

37. "Lumbar Spine: A Prospective Study of Postoperative MR Imaging With Gd-DTPA in Asymptomatic

Patients." Presented at the 6th Annual Meeting of the North American Spine Society, Keystone CO, August 2, 1991.

38. "High Incidence of Hematopoietic Hyperplasia on Knee MR Imaging Examinations of Asymptomatic

Marathon Runners." Presented by E. Morris at the 77th Scientific Assembly of the Radiological Society of North America, Chicago IL, December 1, 1991.

39. "Sequential Post-Operative Lumbar MR Imaging After Successful Disc Surgery." Presented at the

77th Scientific Assembly of the Radiological Society of North America, Chicago IL, December 4, 1991.

40. "Estrogen Treatment During Fracture Repair Strengthens Healing Callus in an Osteoporotic Model."

Presented by M. Bolander at the 38th Annual Meeting of the Orthopaedic Research Society, Washington DC, February 18, 1992.

41. "Impairment Evaluation Based on Spinal Range of Motion in Normal Subjects." Presented by W.

Lowery at the 59th Annual Meeting of the American Academy of Orthopaedic Surgeons, Washington DC, February 20, 1992.

42. "Postoperative Discitis: Distinguishing Early MR Findings from Normal Postoperative Disc Space

Changes." Presented at the Annual Meeting of the International Society for Study of the Lumbar Spine, Chicago, IL, May 22, 1992.

43. "Impairment Evaluation Based on Spinal Range of Motion in Normal Subjects." Presented at the

Ninth Combined Meeting of the Orthopaedic Associations of the English-Speaking World, Toronto, Canada, June 24, 1992.

44. "Contrast-Enhanced MR Imaging Performed after Successful Lumbar Disc Surgery: A Prospective

Study." Presented at the Ninth Combined Meeting of the Orthopaedic Associations of the English-Speaking World, Toronto, Canada, June 25, 1992.

Scott D. Boden, MD July, 2011 28

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 45. "A Quality-Based Protocol for the Management of Low Back Pain and Sciatica: A Ten-Year

Prospective Study." Presented at the 7th Annual Meeting at the North American Spine Society, Boston MA, July 9, 1992.

46. "Postoperative Discitis." Presented at the 7th Annual Meeting of the North American Spine Society,

Boston, MA, July 10, 1992. 47. "Rheumatoid Arthritis of the Cervical Spine." Presented at the 23rd Meeting of the Eastern

Orthopaedic Association, Dorado, P.R., October 16, 1992. 48. "Rheumatoid Arthritis of the Cervical Spine." Presented at the 20th Meeting of the Cervical Spine

Research Society, Palm Desert, CA, December 4, 1992. 49. "A Quality-Based Protocol for the Management of Low Back Pain and Sciatica." Presented by S.W.

Wiesel at the 60th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, February 18, 1993.

50. "Operative Treatment of Syndesmotic Disruption Without Use of a Syndesmotic Screw: A

Prospective Clinical Study." Presented by K. Yamaguchi at the 60th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, February 20, 1993.

51. "Rheumatoid Arthritis of the Cervical Spine: Predictors of Paralysis and Recovery." Presented at

the 60th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, February 20, 1993.

52. "Postoperative Discitis." Presented by T.C. Dina at the 60th Annual Meeting of the American

Academy of Orthopaedic Surgeons, San Francisco, CA, February 22, 1993. 53. "A Quality-Based Protocol for the Management of Low Back Pain and Sciatica: A Ten-Year

Prospective Outcome Study." Presented at the 20th Annual Meeting of the International Society for Study of the Lumbar Spine, Marseille, France, June 18, 1993.

54. "Mineralization by ß-Glycerolphosphate Enhances Osteocalcin Production by MC3T3-E1 Cells in -

MEM but not BGJb." Poster Presentation at the 15th Annual Meeting of the American Society of Bone and Mineral Research, Tampa, FL, September 20, 1993.

55. "Lumbar Facet Joint Orientation: Definitive Evidence for Clinical Relevance." Poster Presentation at

the 40th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, February 21-24, 1994.

56. "Effect of Lumbar Facet Capsule/Cartilage Excision: Does Added Instability Outweigh Increased

Fusion Area?" Poster Presentation at the 40th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, February 21-24, 1994.

57. "A Rabbit Lumbar Spine Intertransverse Process Fusion Model: Radiographic and Biomechanical

Healing Characteristics." Poster Presentation at the 40th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, February 21-24, 1994.

58. "Mineralization by -Glycerolphosphate Enhances Osteocalcin Production by MC3T3-E1 Cells in -

MEM but not BGJb." Presented at the 40th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, February 21, 1994.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 59. "The Effect of Nicotine on Incorporation of Cancellous Bone Graft in an Animal Model." Presented

at the 40th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, February 21, 1994.

60. "Lumbar Facet Joint Tropism: Defining Normal and the Relationship to Disc Disease." Presented at

the 61st Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA, March 1, 1994.

61. "Lumbar Facet Joint Orientation: Definitive Evidence for Clinical Relevance." Presented by K.D.

Riew at the 21st Annual Meeting of the International Society for Study of the Lumbar Spine, Seattle, WA, June 22, 1994.

62. "In Vivo Evaluation of Bovine-Derived Bone Morphogenetic-like Protein as a Graft Substitute for

Lumbar Spine Fusion." Presented at the 21st Annual Meeting of the International Society for Study of the Lumbar Spine, Seattle, WA, June 22, 1994.

63. "Lumbar Facet Capsule/Cartilage Excision: Does Added Instability Outweigh Increased Fusion

Area?" Presented by J.S. Kirkpatrick at the 21st Annual Meeting of the International Society for Study of the Lumbar Spine, Seattle, WA, June 25, 1994.

64. "A Rabbit Model for Lumbar Spine Intertransverse Process Fusion." Poster Presentation at the 21st

Annual Meeting of the International Society for Study of the Lumbar Spine, Seattle, WA, June 22-25, 1994.

65. "Analysis of Sulphated Glycosaminoglycans in Intervertebral Discs at Different Stages of

Degeneration." Poster Presentation at the 21st Annual Meeting of the International Society for Study of the Lumbar Spine, Seattle, WA, June 22-25, 1994.

66. "Experimental Spinal Fusion with Recombinant Human Bone Morphogenetic Protein (rhBMP-2)."

Poster presentation at the 16th Annual Meeting of the American Society for Bone and Mineral Research, Kansas City, MO, September 9-13, 1994.

67. "Cloning of the Catalytic Domain of a Glucocorticoid Regulated Protein Tyrosine Phosphatase from

Differentiated Rat Osteoblasts." Poster presentation by L.Titus at the 16th Annual Meeting of the American Society for Bone and Mineral Research, Kansas City, MO, September 9-13, 1994.

68. "Correlation of Early TGF-_1 mRNA Expression with Late Mineralization After Glucocorticoid-

Induced Osteoblast Differentiation In Vitro." Poster presentation at the 16th Annual Meeting of the American Society for Bone and Mineral Research, Kansas City, MO, September 9-13, 1994.

69. "Experimental Spine Fusion with Human Recombinant Bone Morphogenetic Protein (rhBMP-2)."

Presented by J.H. Schimandle at the 29th Annual Meeting of the Scoliosis Research Society, Portland, OR, September 21-24, 1994.

70. "A Rabbit Model for Lumbar Spine Intertransverse Process Fusion." Presented by J.H. Schimandle

at the 29th Annual Meeting of the Scoliosis Research Society, Portland, OR, September 21-24, 1994.

71. "The Effect of Nicotine on Spinal Fusion: An Animal Model." Presented by D.H. Silcox at the 29th

Annual Meeting of the Scoliosis Research Society, Portland, OR, September 21-24, 1994. 72. "Experimental Spine Fusion with Recombinant Human Bone Morphogenetic Protein (rhBMP-2)."

Presented at the 25th Annual Meeting of the Eastern Orthopaedic Association, Southampton, Bermuda, October 12-16, 1994.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 73. "The Effect of Nicotine on Incorporation of Cancellous Bone Graft in an Animal Model." Presented

by G.D. Reibel at the 9th Annual Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994.

74. "Lumbar Facet/Capsule/Cartilage Excision: Does Added Instability Outweigh Increased Fusion

Area?" Presented by J.S. Kirkpatrick at the 9th Annual Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994.

75. "Lumbar Facet Joint Orientation: Definitive Evidence for Clinical Relevance." Presented by K.D.

Riew at the 9th Annual Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994.

76. "A Rabbit Model for Lumbar Spine Intertransverse Process Fusion." Presented at the 9th Annual

Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994. 77. "In Vivo Evaluation of Bovine-Derived Bone Morphogenetic-like Protein as a Graft Substitute for

Lumbar Spine Fusion." Presented at the 9th Annual Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994.

78. "Experimental Spine Fusion with Recombinant Human Bone Morphogenetic Protein (rhBMP-2)."

Presented at the 9th Annual Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994.

79. "The Effect of Nicotine on Spinal Fusion: An Animal Model." Presented by T.K. Daftari at the 9th

Annual Meeting of the North American Spine Society, Minneapolis, MN, October 19-22, 1994. 80. "In Vivo Evaluation of Bovine-Derived Bone Morphogenetic-like Protein as a Graft Substitute for

Lumbar Spine Fusion." Poster Presentation at the 41st Annual Meeting of the Orthopaedic Research Society, Orlando, FL, February 13-16, 1995.

81. "Correlation of Early TGF-B1 mRNA Expression with Late Mineralization After Glucocorticoid-

Induced Osteoblast Differentiation In Vivo. Poster Presentation at the 41st Annual Meeting of the Orthopaedic Research Society, Orlando, FL, February 13-16, 1995.

82. "Spine Fusion With Recombinant Human Bone Morphogenetic Protein (rhBMP-2): Beginning the

Era of Biologic Spine Fusion." Presented by J.H. Schimandle at the 62nd Annual Meeting of Orthopaedic Surgeons, Orlando, FL, February 16-21, 1995.

83. "In Vivo Evaluation of Bovine-Derived Bone Morphogenetic-like Protein as a Graft Substitute for

Lumbar Spine Fusion." Presented at the 62nd Annual Meeting of Orthopaedic Surgeons, Orlando, FL, February 16-21, 1995.

84. "A Rabbit Model for Lumbar Spine Intertransverse Process Fusion." Poster presentation at the 62nd

Annual Meeting of Orthopaedic Surgeons, Orlando, FL, February 16-21, 1995. 85. "The Effect of Nicotine on Spinal Fusion." Presented by D.H. Silcox at the at the 62nd Annual

Meeting of Orthopaedic Surgeons, Orlando, FL, February 16-21, 1995. 86. "In Vivo Evaluation of Bovine-Derived Bone Morphogenetic-like Protein as a Graft Substitute for

Lumbar Spine Fusion." Presented at the 8th Annual Meeting of the Federation of Spine Associations, Orlando, FL, February 19, 1995.

87. "The Effect of Nicotine on Spinal Fusion." Presented by D.H. Silcox at the 8th Annual Meeting of the

Federation of Spine Associations, Orlando, FL, February 19, 1995. Scott D. Boden, MD July, 2011 31

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 88. "Use of an Osteoinductive Bone Protein for Spinal Fusion." Presented by T.E. Whitesides at the

108th Annual Meeting of the American Orthopaedic Association, White Sulphur Springs, WV, June 11, 1995.

89. "In vivo evaluation of a Resorbable Osteoinductive Composite as a Graft Substitute for Lumbar

Spinal Fusion. Presented at the 22nd Annual Meeting of the International Society for Study of the Lumbar Spine, Helsinki, Finland, June 19, 1995.

90. "The Use of an Osteoinductive Growth Factor for Lumbar Spinal Fusion." Presented at the 22nd

Annual Meeting of the International Society for Study of the Lumbar Spine, Helsinki, Finland, June 19, 1995.

91. "Effects of BMPs on Osteoblast Differentiation." Poster presentation at the Annual Meeting of the

American Society for Bone and Mineral Research, Baltimore, MD, September 11, 1995. 92. "In vivo evaluation of a Resorbable Osteoinductive Composite as a Graft Substitute for Lumbar

Spinal Fusion. Presented at the 20th Annual Meeting of the Scoliosis Research Society, Asheville, SC, September 15, 1995.

93. "Reversing the Effect of Nicotine on Spinal Fusion Using Bone Morphogenetic Protein: An Animal

Model." Presented by D. Hal Silcox, III, at the 30th Annual Meeting of the Scoliosis Research Society, Asheville, SC, September 15, 1995.

94. "In vivo evaluation of a Resorbable Osteoinductive Composite as a Graft Substitute for Lumbar

Spinal Fusion. Presented at the 10th Annual Meeting of the North American Spine Society, Washington, DC., October 19, 1995.

95. "Reversing the Effect of Nicotine on Spinal Fusion Using Bone Morphogenetic Protein: An Animal

Model." Presented at the 10th Annual Meeting of the North American Spine Society, Washington, DC., October 19, 1995.

96. "Evaluation of a Bovine-Derived Osteoinductive Bone Protein in a Non-Human Primate Model of

Lumbar spinal Fusion." Presented at the 10th Annual Meeting of the North American Spine Society, Washington, DC., October 19, 1995.

97. "Spatial and Temporal Histologic Quantitation of Lumbar Intertransverse Process Spine Fusion

Healing." Presented at the 10th Annual Meeting of the North American Spine Society, Washington, DC., October 19, 1995.

98. “Evaluation of a Bovine-Derived Osteoinductive Bone Protein in a Non-Human Primate Model of

Lumbar Spinal Fusion.: Presented at the 42nd Annual Meeting of the Orthopaedic Research Society, Atlanta, GA, February 19, 1996.

99. “Effects of BMPs on Osteoblast Differentiation In Vitro." Poster Presentation at the 42nd Annual

Meeting of the Orthopaedic Research Society, Atlanta, GA, February 18-22, 1996. 100. “Reversing the Inhibitory Effect of Nicotine on Spinal Fusion Using an Osteoinductive Bone Protein

Extract.” Poster Presentation at the 42nd Annual Meeting of the Orthopaedic Research Society, Atlanta, GA, February 18-22, 1996.

101. “Evaluation of Bovine-Derived Bone Morphogenetic-like Proteins as a Graft Substitute for Lumbar

Spinal Fusion In Vivo.” Poster Presentation at the 63rd Annual Meeting of the American Academy of Orthopaedic Surgeons, Atlanta, GA, February 24, 1996.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 102. “Evaluation of a Bovine-Derived Osteoinductive Bone Protein in a Non-Human Primate Model of

Lumbar Spinal Fusion.” Presented at the 63rd Annual Meeting of the American Academy of Orthopaedic Surgeons, Atlanta, GA, February 24, 1996.

103. “Reversing the Inhibitory Effect of Nicotine on Spinal Fusion Using an Osteoinductive Bone Protein

Extract.” Presented by D. Hal Silcox at the 63rd Annual Meeting of the American Academy of Orthopaedic Surgeons, Atlanta, GA, February 24, 1996.

104. “Glucocorticoid-Induced Differentiation of Fetal Rat Calvarial Osteoblasts Is Mediated by BMP-6.”

Presented at the 18th Annual Meeting of the American Society of Bone and Mineral research, Seattle WA, September 10, 1996.

105. “Do Diurnal Changes in Loading Affect the Interpretation of MRI Scans of the Lumbar Spine?”

Presented at the 27th Annual Meeting of the Eastern Orthopaedic Association, Hilton Head, S.C., October 17, 1996.

106. “Video-Assisted Lateral Intertransverse Process Arthrodesis BValidation of a New Minimally

Invasive Lumbar Spinal Fusion Technique in the Rabbit and Non-human Primate (Rhesus) Models.” Presented at the 11th Annual Meeting of the North American Spine Society, Vancouver, B.C., October 25, 1996.

107. “Demineralized Bone Matrix as a Graft Extender in Posterolateral Lumbar Spine Arthrodesis.”

Presented by M.A. Morone at the 11th Annual Meeting of the North American Spine Society, Vancouver, B.C., October 25, 1996.

108. “Video-Assisted Lateral Intertransverse Process Arthrodesis BValidation of a New Minimally

Invasive Spinal Fusion Technique.” Poster Presentation at the 43rd Animal Meeting of the Orthopaedic Research Society, San Francisco, CA., February 9, 1997.

109. “Gene Expression During Experimental Posterolateral Lumbar Spinal Fusion.” Presented at the

43rd Annual Meeting of the Orthopedic Research Society, San Francisco, CA., February 11, 1997. 110. “Revascularization of the Fusion Mass in a Posterolateral Intertransverse Process Fusion.”

Presented by Y. Toribatake at the 43rd Annual Meeting of the Orthopedic Research Society, San Francisco, CA., February 11, 1997.

111. “Glucocorticoid-Induced Differentiation of Fetal Rat Calvarial Osteoblasts Is Mediated by BMP-6.”

Presented at the 43rd Annual Meeting of the Orthopedic Research Society, San Francisco, CA., February 12, 1997.

112. “Reversing the Inhibitory Effect of Nicotine on Spinal Fusion Using an Osteoinductive Bone Protein

Extract.” Poster presentation at the 64th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, February 15, 1997.

113. “The Use of a New Form of Demineralized Bone Matrix in Experimental Spine Fusion.” Presented

by G. Martin at the Joint Section on Disorders of the Spine and Peripheral Nerves, NewPort Beach, CA., February 19, 1997.

114. “Gene Expression During Lumbar Spine Fusion: A Molecular Basis for Preventing Nonunions.”

Presented at the Annual Meeting of the Association of Bone and Joint Surgeons, Scotsdale, AZ, May 1, 1997.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 115. “Laparoscopic Anterior Spinal Arthrodesis With rhBMP-2 in a Titanium Interbody Threaded Cage.”

Presented by G.J. Martin at the 10th Annual International Intradiscal Therapy Society Meeting, Naples, FL., May 28, 1997.

116. “Laparoscopic Anterior Spinal Arthrodesis With rhBMP-2 in a Titanium Interbody Threaded Cage.”

Presented at the 24th Annual Meeting of the International Society for Study of the Lumbar Spine, Singapore, June 3, 1997.

117. “Patient-based Health Outcome Assessment for Spinal Diagnostic Groups.” Presented by T.J.

Albert at the 24th Annual Meeting of the International Society for Study of the Lumbar Spine, Singapore, June 3, 1997.

118. “Gene Expression During Posterolateral Lumbar Spine Fusion: Effect of BMP-2." Presented at the

24th Annual Meeting of the International Society for Study of the Lumbar Spine, Singapore, June 6, 1997.

119. “Revascularization of the Fusion Mass in Posterolateral Intertransverse Process Fusion.” Presented

by Y. Toribatake at the 24th Annual Meeting of the International Society for Study of the Lumbar Spine, Singapore, June 6, 1997.

120. “Gene Expression During Lumbar Spinal Fusion.” Presented by M.A. Morone at the Southern

Neurosurgical Society, Pinehurst, N.C., June 5, 1997. 121. “Video-Assisted Lateral Intertransverse Process Arthrodesis: Validation of a New Minimally Invasive

Technique in a Large Animal (Goat) Model.” Presented by P.A. Moskovitz at the 4th International Meeting on Advanced Spine Techniques, Bermuda, July 10, 1997.

122. “Laparoscopic Anterior Spinal Arthrodesis with rhBMP-2 in a Titanium Interbody Threaded Cage.”

Presented by G.J. Martin at the 1997 CNS Annual Meeting, New Orleans, LA, October 1, 1997. 123. “The Use of Two New Forms of Demineralized Bone Matrix in Experimental Posterolateral Lumbar

Spine Arthrodesis.” Presented by G.J. Martin at the 1997 CNS Annual Meeting, New Orleans, LA, October 1, 1997.

124. “Gene Expression During Lumbar Spine Fusion.” Presented at the 12th Annual Meeting of the

North American Spine Society, New York, NY, October 24, 1997. 125. “Laparoscopic Anterior Spinal Arthrodesis with rhBMP-2.” Presented by W. C. Horton at the 12th

Annual Meeting of the North American Spine Society, New York, NY, October 25, 1997. 126. “Video-Assisted Lateral Intertranverse Process Arthrodesis.” Presented by P.A. Moskovitz at the

12th Annual Meeting of the North American Spine Society, New York, NY, October 25, 1997. 127. “A Novel LIM Protein Involved in Bone Mineralization.” Presented at the 44th Annual Meeting of the

Orthopaedic Research Society, New Orleans, LA, March 16, 1998. 128. ”Posterolateral Lumbar Spinal Arthrodesis with rhBMP-2/Hydroxyapatite - Tricalcium Phospate

(HA-TCP) Following Laminectomy in the Non-Human Primate.” Presented at the 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 1, 1998.

129. “BMP-2 Reverses the Inhibitory Effect of Ketorolac on Posterolateral Spine Fusion.” Poster

Presentation at the 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 16, 1998.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 130. “Gene Expression during Posterolateral Lumbar Spine Fusion: Effect of BMP-2.” Poster

Presentation at the 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, March 16, 1998.

131. “Gene Expression during Posterolateral Lumbar Spine Fusion: Effect of BMP-2.” Presented at the

65th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA, March 20, 1998.

132. “The Use of Two New Forms of Demineralized Bone Matrix in Experimental Posterolateral Lumbar

Spine Arthrodesis.” Presented at the 65th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA, March 20, 1998.

133. “BMP-2 Reverses the Inhibitory Effect of Ketorolac on Posterolateral Spine Fusion.” Presented by

G.J. Martin at the 65th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA, March 20, 1998.

134. “Laparoscopic Anterior Spinal Arthrodesis with rhBMP-2.” Presented by W.C. Horton at the 65th

Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA, March 20, 1998.

135. “Gene Expression during Posterolateral Lumbar Spine Fusion: Effect of BMP-2.” Presented at the

Federation of Spine Association Annual Meeting, New Orleans, LA, March 22, 1998. 136. “In Vivo Evaluation of a Ceramic Osteoinductive Composite as a Graft Substitute for Lumbar Spinal

Fusion.” Presented at the 25th Annual Meeting of the International Society for Study of the Lumbar Spine. Brussels, Belgium, June 11, 1998.

137. “BMP-2 Reverses the Inhibitory Effect of Ketorolac, a NSAID, on Posterolateral Lumbar

Intertransverse Process Spine Fusion.: Presented at the 25th Annual Meeting of the International Society for Study of the Lumbar Spine, Brussels, Belgium, June 11, 1998.

138. “Spine Fusion by Local Gene Therapy and LMP-1.” Presented at the 25th Annual Meeting of the

International Society for Study of the Lumbar Spine, Brussels, Belgium, June 11, 1998. 139. “Lumbar Spine Fusion by Local Gene Therapy.” Presented at the 29th Annual Meeting of the

Eastern Orthopaedic Association, Dorado, P.R., October 17, 1998. 140. ”In Vivo Evaluation of a Ceramic Osteoinductive Composite as a Graft Substitute for Lumbar Spinal

Fusion.” Presented at the 13th Annual Meeting of the North American Spine Society, San Francisco, CA, October 28, 1998.

141. “Posterolateral Lumbar Spinal Arthrodesis with rhBMP-2/Hydroxyapatite-Tricalcium Phosphate (HA-

TCP) Following Laminectomy in the Non Human Primate.” Presented at the 13th Annual Meeting of the North American Spine Society, San Francisco, CA, October 29, 1998.

142. ”Lumbar Spine Fusion by Local Gene Therapy with a cDNA Encoding a Novel Osteoinductive

Protein (LMP-1).” Presented at the 13th Annual Meeting of the North American Spine Society, San Francisco, CA, October 30, 1998.

143. “An Assessment of the Early Management of Spine Problems and Appropriateness of Diagnostic

Imaging Utilization.” Presented at the 13th Annual Meeting of the North American Spine Society, San Francisco, CA, October 31, 1998.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 144. “Glucocorticoid/BMP-6 Induction of Osteoblast Differentiation Is Mediated by Increased LTBP-1

Expression.” Presented at the 45th Annual Meeting of the Orthopaedic Research Society, Anaheim, CA, February 2, 1999.

145. “The Use of rhBMP-2 in Interbody Fusion Cages: Definitive Evidence of Osteoinduction in Humans.”

Presented at the 66th Annual Meeting of the American Academy of Orthopaedic Surgeons. Anaheim, CA, February 7, 1999.

146. “Lumbar Spine Fusion by Local Gene Therapy With a cDNA Encoding a Novel Osteoinductive

Protein (LMP-1).” Presented at the 66th Annual Meeting of the American Academy of Orthopaedic Surgeons. Anaheim, CA, February 7, 1999.

147. “The Use of rhBMP-2 in Interbody Fusion Cages: Definitive Evidence of Osteoinduction in Humans.”

Presented at the 26th Annual Meeting of the International Society for Study of the Lumbar Spine, Kona, HI, June 22, 1999.

148. “An Assessment of the Early Management of Spine Problems and Appropriateness of Diagnostic

Imaging Utilization.” Presented at the 26th Annual Meeting of the International Society for Study of the Lumbar Spine, Kona, HI, June 22, 1999.

149. “Adenovirus-mediated Gene Transfer of a Novel Osteoinductive LMP-1 cDNA Induces Nodule

Formulation In Vitro and Bone Formation In Vivo.” Presented at the 21st Annual Meeting of the American Society for Bone and Mineral Research, St. Louis, MO, October 2, 1999.

150. “Use of Low Dose Adenovirus for Local Gene Therapy in Lumbar Spine Fusion.” Presented at the

30th Annual Meeting of the Eastern Orthopaedic Association, Vienna, Austria, October 15, 1999. 151. “Use of Low dose Adenovirus for Local Gene Therapy in Lumbar Spine Fusion.” Presented at the

14th Annual Meeting of the North American Spine Society, Chicago, IL, October 21, 1999. 152. “Effect of Nicotine on Gene Expression During Spine Fusion. Presented at the 14th Annual Meeting

of the North American Spine Society, Chicago, IL, October 21, 1999. 153. “Identification, Cloning, Sequencing, and Function of Human LMP-l.” Poster presentation at the

American Society for Bone and Mineral Research, St. Louis MO, October 2, 1999. 154. “The Effect of Nicotine on Gene Expression During Spine Fusion.” Poster Presentation at the 46th

Annual Meeting of the Orthopaedic Research Society, Orlando, Fl, March 11, 2000. 155. “Use of Low Dose Adenovirus for Local Gene Therapy in Lumbar Spine Fusion.” Presented at the

46th Annual Meeting of the Orthopaedic Research Society, Orlando, Fl, March 14, 2000. 156. “Adenoviral Delivery of LIM Mineralization Protein-1 Successfully Induces de novo Bone Formation

in vivo.” Presented at the 67th Annual Meeting of the American Academy of Orthopaedic Surgeons, Orlando FL, March 17, 2000.

157. “Use of Low Dose Adenovirus for Local Gene Therapy in Lumbar Spine Fusion.” Presented at the

27th Annual Meeting of the International Society for Study of the Lumbar Spine. Adelaide, Australia, April 11, 2000.

158. “Adenoviral Delivery of LIM Mineralization Protein-1 Successfully Induces Bone Formation in vivo.”

Presented at the 34th Annual Meeting of the American Society for Gene Therapy, Denver, CO, June 3, 2000.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 159. “Use of Low Dose Adenovirus for Local Gene Therapy in Spine Fusion.” Presented at the 113th

Annual Meeting of the American Orthopaedic Association, Hot Springs, VA, June 16, 2000. 160. “Adenoviral Delivery of LIM Mineralization Protein-1 (LMP-1) Induces de novo Bone Formation in

Vivo.” Presented at the 31st Annual Meeting of the Eastern Orthopaedic Association, Orlando, FL, October 13, 2000.

161. “Adenoviral Delivery of LMP-1 Successfully Induces de novo Bone Formation in Vivo.” Presented at

the 15th Annual Meeting of the North American Spine Society, New Orleans, LA, October 27, 2000. 162. “Adenoviral Delivery of LMP-1 Induces Consistent Spine Fusion.” Presented at the 47th Annual

Meeting of the Orthopaedic Research Society, San Francisco CA, February 28, 2001. 163. “Adenoviral Delivery of LMP Mineralization Protein-1 Successfully Induces Lumbar Spine Fusion.”

Presented at the 68th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco CA, March 4, 2001.

164. “Evaluation of rhBMP-2 With Various Ceramic/Collagen Sponges Carriers in Posterolateral Spine

fusion in the Rabbit and Non-human Primate.” Presented at the 28th Annual Meeting of the International Society for Study of the Lumbar Spine, Edinburgh, Scotland, June 22, 2001.

165. “Overcoming the Immune Response to Permit Ex Vivo Gene Therapy for Spine Fusion With Type 5

Adenoviral Delivery of the LMP-1 cDNA.” Presented by Hak-Sun Kim at the 28th Annual Meeting of the International Society for Study of the Lumbar Spine, Edinburgh, Scotland, June 22, 2001.

166. “Mechanism of Bone Formation Induced by LMP-1.” Poster presentation by Akhito MInamide at the

American Society for Bone and Mineral Research. Dallas, TX, October 13, 2001. 167. “Ne-Osteo Bone Growth Factor for Posterolateral Lumbar Spine Fusion: A Prospective Human

Clinical Pilot Study.” Presented at the 32nd Annual Meeting of the Eastern Orthopaedic Association, Southampton, Bermuda, October 12, 2001.

168. “Evidence of Osteoinduction by Grafton DBM in Non-Human Primate Fusion.” Presented at the 32nd

Annual Meeting of the Eastern Orthopaedic Association, Southampton, Bermuda, October 12, 2001. 169. “Use of rhBMP-2 Supplemented with Allograft Bone Chips in Posterolateral Fusions in Non-Human

Primates.” Presented at the 32nd Annual Meeting of the Eastern Orthopaedic Association, Southampton, Bermuda, October 12, 2001.

170. “Overcoming the Immune Response to Permit Ex Vivo Gene Therapy for Gene fusion with Type 5

Adenoviral delivery of LIM Mineralization Protein-1 (LMP-1) cDNA.” Poster presentation at the 16th Annual Meeting of the North American Spine Society, Seattle, WA, October 31, 2001.

171. “Ne-Osteo Bone Growth Factor for Posterolateral Lumbar Spine Fusion: A Prospective Human

Clinical Pilot Study.” Presented by the 16th Annual Meeting of the North American Spine Society, Seattle, WA, November 1, 2001.

172. “Evidence of Osteoinduction by Grafton DBM in Non-Human Primate Spine Fusion.” Presented at

the 16th Annual Meeting of the North American Spine Society, Seattle, WA, November 3, 2001. 173. “Use of rhBMP-2 Supplemented with Allograft Bone Chips in Posterolateral Fusions in Non-Human

Primates.” Poster presentation at the 16th Annual Meeting of the North American Spine Society, Seattle, WA, October 31, 2001.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 174. “Overcoming the Immune Response to Permit Ex vivo Gene Therapy for Spine Fusion with

Adenoviral Delivery of the LIM Mineralization Protein–1 (LMP-1) cDNA.” Poster Presentation at the 48th Annual Meeting of the Orthopaedic Research Society, Dallas, TX, February 9-12, 2002.

175. “Ne-Osteo Bone Growth Factor for Posterolateral Lumbar Spine Fusion: A Prospective Human

Clinical Pilot Study.” Presented at the 48th Annual Meeting of the Orthopaedic Research Society, Dallas TX, February 13, 2002.

176. “Mechanism of Bone Formation Induced by Ad-LMP-1: Histological and Immunohistochemical

Studies.” Presented at the 48th Annual Meeting of the Orthopaedic Research Society, Dallas TX, February 11, 2002.

177. “Evaluation of rhBMP-2 with Various Ceramic/Collagen Sponge Carriers in Posterolateral Spine

Fusion in the Rabbit and Non-Human Primate.” Poster presentation at the 48th Annual Meeting of the Orthopaedic Research Society, Dallas TX, February 9-12, 2002.

178. “Overcoming the Immune Response to Permit Ex Vivo Gene Therapy for Spine Fusion with Type 5

Adenoviral Delivery of the LIM Mineralization Protein (LMP-1) cDNA.” Presented at the 69th Annual Meeting of the American Academy of Orthopaedic Surgeons, Dallas TX, February 13, 2002.

179. “Evaluation of the rhBMP-2 with Various Ceramic/Collagen Sponge Carriers in Posterolateral Spine

Fusion in the Rabbit and in the Non-Human Primate.” Presented at the 69th Annual Meeting of the American Academy of Orthopaedic Surgeons, Dallas TX, February 14, 2002.

180. “Use of rhBMP-2 Supplemented with Allograft Bone Chips in Posterolateral Fusions in Non-Human

Primates.” Presented at the 69th Annual Meeting of the American Academy of Orthopaedic Surgeons, Dallas TX, February 14, 2002.

181. “Ne-Osteo Bone Growth Factor For Posterolateral Lumbar Spine Fusion — A Prospective Human

Pilot Study.” Presented at the 69th Annual Meeting of the American Academy of Orthopaedic Surgeons, Dallas TX, February 15, 2002.

182. “Ne-osteo Bone Growth Factor for Posterolateral Lumbar Spine Fusion: A Prospective Human

Clinical Pilot Study.” Presented by Dieter Grob at the 29th Annual Meeting of the International Society for Study of the Lumbar Spine, Cleveland OH, May 17, 2002.

183. “Mechanism of Bone Formation by LMP-1 Gene Therapy.” Presented at the 29th Annual Meeting of

the International Society for Study of the Lumbar Spine, Cleveland OH, May 17, 2002. 184. “Use of rhBMP-2 to Achieve Posterolateral Spine Fusion in Humans.” Presented at the 29th Annual

Meeting of the International Society for Study of the Lumbar Spine, Cleveland OH, May 17, 2002. 185. “Gene Therapy with LMP-1 Increases Intervertebral Disc Cell Proteoglycan Production and Changes

Cell Phenotype.” Presented by Tim Yoon at the 29th Annual Meeting of the International Society for Study of the Lumbar Spine, Cleveland OH, May 17, 2002.

186. “Low Dose Ad-LMP-1 Transduction of Non-Human Primate Cells Induces Ectopic Bone Formation in

Athymic Rats.” Poster Presented at the American Society for Gene Therapy, Boston, MA, June 8, 2002.

187. “A Region of the rhBMP-6 Promoter Contributing to Basal and Glucocorticoid-Mediated Effects.”

Poster Presented at the 24th Annual Meeting of the American Society for Bone and Mineral Research, San Antonio, TX, September 20-24, 2002. Abstract # SU198.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 188. “Overcoming the Immune Response to Permit Ex Vivo Gene Therapy for Spine Fusion Using

Human Type 5 Adenovirus to Deliver LIM Mineralization Protein-1 (LMP-1) cDNA.” Poster Presented at the 24th Annual Meeting of the American Society for Bone and Mineral Research, San Antonio, TX, September 20-24, 2002. Abstract # M045.

189. “The Involvement of LMP-1 in Prostate Cancer Metastases Bone.” Poster Presented at the 24th

Annual Meeting of the American Society for Bone and Mineral Research, San Antonio, TX, September 20-24, 2002. Abstract #M068.

190. “Use of rhBMP-2 to Achieve Posterolateral Spine Fusion in Humans: A Prospective and

Randomized Clinical Pilot Trial.” Presented at the 33rd Annual Meeting of the Eastern Orthopaedic Association. Amelia Island, Florida, October 18, 2002.

191. ”rhBMP-2 for Posterolateral Spine Fusion: A Prospective, Randomized Clinical Trial.: Presented at

the 17th Annual Meeting of the North American Spine Society. Montreal, Canada, November 1, 2002.

192. “Simple Carrier Matrix Modifications Can Enhance Delivery of rhBMP-2 for Posterolateral Spine

Fusion.” Poster Presentation at the 49th Annual Meeting of the Orthopaedic Research Society, February 3, 2003, New Orleans, LA.

193. “LMP-1 Overexpression in Intervertebral Discs Cells Increases BMP-2 Gene Expression and

Regulates Proteoglycan Production.” Presented by J-S. Park at the 49th Annual Meeting of the Orthopaedic Research Society. February 2, 2003, New Orleans, LA.

194. “Use of rhBMP-2 to achieve Posterolateral Spine Fusion in Humans: A Prospective and

Randomized Trial.” Poster Presentation at the 70th Annual Meeting of the American Academy of Orthopaedic Surgeons. New Orleans, LA, February 5-9, 2003.

195. “Use of a Recombinant LMP-1 Fusion Protein to Induce Spine Fusion Without Risks of Gene

Therapy.” Presented at the 30th Annual Meeting of the International Society for the Study of the Lumbar Spine. Vancouver, B.C., May 17, 2003.

196. “Intervertebral Disc Replacements: This time have we really cured back and neck pain?”. Critical

Issues Symposium presented at the annual meeting of the American Orthopaedic Association. Charleston, SC, June 13, 2003.

197. “Optimized Carrier Matrix Allows Lower Dose of rhBMP-2 to Achieve Spine Fusion in Non-Human

Primates.” Presented at the 18th Annual Meeting of the North American Spine Society. San Diego, CA, October 23, 2003.

198. “Use of a Recombinant LMP-1 Fusion Protein to Induce Spine Fusion Without Risks of Gene

Therapy.” Presented at the 18th Annual Meeting of the North American Spine Society. San Diego, CA, October 23, 2003.

199. “The Use of a Recombinant LMP-1 Fusion Protein to Induce Spine Fusion Without Risks of Gene

Therapy.” Presented at the 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 10, 2004.

200. “Comparison of Healos/Bone Marrow to InFuse with a Collagen-Ceramic Sponge Bulking Agent as

Graft Substitutes for Lumbar Fusion.” Poster presented at the 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 10, 2004.

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ORAL AND POSTER PRESENTATIONS (National, Regional): (Cont.) 201. “LMP-1 Upregulates Proteoglycan Production and BMP-2 in Degenerated Human Cervical Disc

Cells.” Presented by Emad Attalah-Wasif at the 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 10, 2004.

202. “Age-Related Intervertebral Disc Degeneration in the Rabbit.” Presented by Tim Yoon at the 31st

Annual Meeting of the International Society for Study of Lumbar Spine, Porto, Portugal, June 2, 2004.

203. “Biological Treatment for Intervertebral Disc Degeneration.” Presented by Emad Attalah-Wasif at

the 31st Annual Meeting of the International Society for Study of Lumbar Spine, Porto, Portugal, June 2, 2004.

204. “LMP-1 Upregulates Intervertebral Disc Cell Production of Proteoglycans and BMPs in Vitro and in

Vivo.” Presented by Tim Yoon at the 31st Annual Meeting of the International Society for Study of Lumbar Spine, Porto, Portugal, June 3, 2004.

205.”LMP-1 Gene Therapy of Human Marrow Cells Upregulates Proteoglycan and BMP Synthesis.”

Presented by Emad Attalah-Wasif at the 31st Annual Meeting of the International Society for Study of Lumbar Spine, Porto, Portugal, June 4, 2004.

206. “Optimized Carrier Matrix Allows Low Dose of rhBMP-2 to Achieve Spine Fusion in Non-Human

Primates. Presented at the 31st Annual Meeting of the International Society for Study of Lumbar Spine, Porto, Portugal, June 4, 2004.

207. “Comparison of Healos/Bone Marrow to InFuse with a Collagen-Ceramic Sponge Bulking Agent as

Graft Substitutes for Lumbar Spine Fusion.” Presented at the 31st Annual Meeting of the International Society for Study of Lumbar Spine, Porto, Portugal, June 4, 2004.

208. “Comparison of Healos/Bone Marrow to InFuse with a Collagen-Ceramic Sponge Bulking Agent as

Graft Substitutes for Lumbar Spine Fusion.” Presented at the 19th Annual Meeting of the North American Spine Society, Chicago, IL, October 28, 2004.

209. Viggeswarapu, M, Bargouti, M, Teklemariam, M, Baker, N, Rogers, C, Zhu, L, Titus, L, Boden, SD:

Increasing BMP Responsiveness in Human Mesenchymal Stem Cells in Vitro by Addition of the Osteoinductive LMP-1 Gene. Presented by M Viggeswarapu on September 26th at the 27th annual meeting of the American Society for Bone and Mineral Research, Nashville, TN, September 23-27, 2005.

210. Sangadala, S, Liu, Y, Viggeswarapu, M, Boden, SD, Titus L, LMP-1 Interacts with Smurf1and

Potentiates Cellular Responsiveness to BMP-2. Presented by S Sangadala on September 26th at the 27th annual meeting of the American Society for Bone and Mineral Research, Nashville, TN, September 23-27, 2005.

211. Viggeswarapu M, Bargouti M, Teklemariam M. Rogers L, Baker N, Titus L, Boden SD. “Increasing

BMP Responsiveness in Human Mesenchymal Stem Cells in vitro by Delivery of the Osteoinductive LMP-1 gene.” Presented by M Viggerswarapu at the 9th Annual Meeting of the American Society for Gene Therapy. Baltimore, MD, June 2, 2006.

212. Sangadala S, Boden SD, Viggeswarapu M, Liu Y, Titus L. “Inhibition of smurf1 potentiates BMP-2 activity.” Presented by S Sangadala at the 28th Annual Meeting of the American Society for Bone and Mineral Research. Philadelphia PA, September 17, 2006.

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ORAL AND POSTER PRESENTATIONS (Local): 1. "Osteoporosis: A New Look at an Old Disease." Presented at Orthopaedic Surgery Grand Rounds,

George Washington University, Washington D.C., March 17, 1988. 2. "Bone Mineral Density in Young Patients With Hip Fractures." Presented at the Washington

Orthopaedic Society, Washington, D.C., April 11, 1988. 3. "Quantitating Osteoporosis: A Radiology Update." Presented at Radiology Rounds, George

Washington University, Washington, D.C., July 22, 1988. 4. "Current Issues on Imaging of Lumbar Spine Instability and Disc Disease." Presented at

Orthopaedic Surgery Grand Rounds, George Washington University, Washington, DC, April 13, 1989.

5. "Abnormal Lumbar Spine MRI Scans in Asymptomatic Individuals." Presented at the Washington

Orthopaedic Society, Washington, DC, April 17, 1990. 6. "Estrogen Treatment Strengthens Mechanical Properties of Healing Fracture Callus in an

Osteoporotic Model." Presented at the Washington Orthopaedic Society, Washington, DC, April 12, 1990.

7. "Abnormal MR Scans of the Knee in Asymptomatic Individuals." Presented at the Washington

Orthopaedic Society, Washington, DC, April 8, 1991. 8. "Postoperative MR Imaging With Gadolinium After Successful Lumbar Disc Surgery: A Prospective

Investigation." Presented at Orthopaedic Surgery Grand Rounds, George Washington University, Washington, DC, May 30, 1991.

9. "Pitfalls in MR Imaging of the Spine." Presented at the Annual Meeting of the Cleveland

Orthopaedic Club, Cleveland, OH, October 28, 1991. 10. "Musculoskeletal Injuries in the Workplace." Presented at Orthopaedic Surgery Grand Rounds,

Emory University, Atlanta, GA, September 29, 1992. 11. "A Rabbit Model for Spinal Fusion." Presented at the North American Traveling Fellows Didactic

Program, Emory University, Atlanta, GA, October 27, 1993. 12. "Spinal Imaging." Presented at Rehabilitation Medicine Conference, Emory University, Atlanta, GA,

November 8, 1994. 13. "Rheumatoid Arthritis and the Cervical Spine." Presented at Rheumatology Department Grand

Rounds, Emory University, Atlanta, GA, December 6, 1994. 14. "Management of the Herniated Lumbar Disc." Presented at Rehabilitation Medicine Conference,

Emory University, Atlanta, GA, December 6, 1994. 15. "Management of Low Back Pain in a Managed Care Environment.: Presented at Neurosurgery

Department Grand Rounds, Emory University, Atlanta, GA, August 23, 1995. 16. "The Use of an Osteoinductive Growth Factor for Lumbar Spinal Fusion." Presented at the Annual

Meeting of the Georgia Orthopaedic Society, Sea Island, GA, October 8, 1995. 17. “Bone Growth Factors: Animal Studies and Potential Clinical Uses.” Presented at Endocrinology

Grand Rounds, Emory University, Atlanta, GA. October 25, 1995. Scott D. Boden, MD July, 2011 41

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ORAL AND POSTER PRESENTATIONS (Local): (cont.) 18. “Bone Growth Factors – Current Status of BMP.” Presented at the Orthopedic Grand Rounds at

Piedmont Hospital, Atlanta, GA., May 5, 1997. 19. “Use of Growth Factors to Regenerate Bone.” Presented at the Emory Department of General

Surgery Grand Rounds, Emory University, Atlanta, GA., May 15, 1997. 20. “Medical and Surgical Management of the Spine.” Presented to Department of Physical Therapy

Masters Students, Atlanta, GA, October 6, 1998. 21. “Bone Graft Substitutes: Present, Future, Next Generation.” Presented at the Emory Department of

Orthopaedic Surgery Grand Rounds, Atlanta, GA, October 17, 1999. 22. “Rheumatoid Disease of the Cervical Spine.” Presented at Grand Rounds, Emory Department of

Rehabilitation Medicine, Atlanta GA, December 21, 2000. 23. “Medical and Surgical Management of the Spine.” Presented to the Emory Department of Physical

Therapy Masters Students, Atlanta GA, October 8, 2001. 24. “Indications for Spine Fusion.” Presented to the National Association of Orthopaedic Nurses.”

Atlanta GA, February 23, 2002. 25. “Management of Low Back Pain.” Presented to CIGNA Healthcare, Atlanta GA, February 26, 2002. 26. “BMP Update.” Presented at Grand Rounds, Emory Department of Neurosurgery, Atlanta, GA, June

17, 2004. 27. “Bone, Back and Joint Health”. Presented to Emory Mini-Medical School, February 26, 2008.

Atlanta, GA. TEACHING AND COMMUNITY SERVICE (NON-MEDICAL AUDIENCE) 1. Indications for Low Back Surgery for a Presumed Herniated Disc with Nerve Root Impingement.

Hippocrates’ Lantern 2:4, pp 1-4, 1994. 2. “Bones and the Spine.” Presented at the Emory University Mini Medical School, Atlanta, GA,

November 8, 1994. 3. “The Musculoskeletal System and the Spine.” Presented at the Emory University Mini Medical

School, Atlanta, GA, October 10, 1995.

4. “Managing Low Back Pain in a Managed Care Environment.” Presented to the GHA Telnet Series (Emory Update), Georgia, April 29, 1998.

5. Curbing costly tests for back pain. Strategic Medicine, November, 1998, pp. 2-7. 6. ”Orthopaedics - Latest Research and Advances.” Presented at the Emory Mini-Medical School.

Atlanta, GA, October 17, 2000.

Scott D. Boden, MD July, 2011 42