curriculum vitae name: brian r. curtis, ph.d., d(abmli), mt(ascp… curtis cv 2018.pdf · brian...

CURRICULUM VITAE

NAME: Brian R. Curtis, Ph.D., D(ABMLI), MT(ASCP)SBB WORK ADDRESS:

PLACE OF BIRTH: EDUCATION: 1980 - 1982 Biology & Chemistry, Drake University, Des Moines, Iowa 1982-1984 B.S. Biology, Iowa State University, Ames, Iowa 1995 - 1998 M.S. Transfusion Medicine Science, Marquette University, Milwaukee, Wisconsin 2006-2010 Ph.D. Health Sciences (Immunology), University of Wisconsin-Milwaukee SPECIALTY TRAINING:

1985-1986 Internship, Medical Technology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 1990-1991 Internship, Specialist in Blood Bank (SBB), Barnes Hospital & Washington University School

of Medicine, St. Louis, Missouri

PROFESSIONAL EXPERIENCE: 1985 Phlebotomist, University of Iowa Hospitals and Clinics, Iowa City, Iowa 1986 Laboratory Assistant, University of Iowa Pathology Department, Iowa City, Iowa 1986-1987 Medical Technologist, Chemistry, Urinalysis, Serology, Blood Bank, Memorial Hospital,

Belleville, Illinois 1987-1990 Medical Research Associate, in the laboratory of Dr. Hugh Chaplin, Jr., Washington

University School of Medicine, St. Louis, Missouri 1989-1991 Medical Technologist, Blood Bank, Barnes Hospital, St. Louis, Missouri 1991-1999 Product Development Specialist, The Blood Center of Southeastern Wisconsin, Milwaukee,

Wisconsin 1991 – 2010 Research and Development Consultant, Genetic Testing Institute (GTI), Brookfield, WI

Brian R.Curtis, Brian R. 1/10/2018

1995-1999 Supervisor, Neutrophil Antibody and PNH Laboratory, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin

1999-2001 Supervisor, Platelet & Neutrophil Immunology Laboratory, The Blood Center of Southeastern

Wisconsin, Milwaukee, Wisconsin 2001-2010 Technical Director, Platelet & Neutrophil Immunology Laboratory, BloodCenter of

Wisconsin, Milwaukee, WI 2010- present Director, Platelet & Neutrophil Immunology Lab, BloodCenter of Wisconsin 2016 – present Director of Operations, Hemostasis Lab, BloodCenter of Wisconsin 2016 – 2017 Senior Clinical Laboratory Director, BloodCenter of Wisconsin 2017 – present Senior Director Versiti Product Development and Clinical Labs, BloodCenter of Wisconsin APPOINTMENTS:

2012 – present Investigator, Blood Research Institute, BloodCenter of WI 2012 – present Assistant Adjunct Professor, Clinical and Translational Science Institute, Medical College of

Wisconsin, Milwaukee, WI COMMITTEES/BOARDS:

1997 – present ISBT Granulocyte Antigen Nomenclature Working Party 2007 – 2015 AABB TRALI Working Group 2007 ISBT International Platelet Immunology Workshop Org. Committee 2011 REDSIII Alloimmunization and Immunology Working Group (Co-chair) 2011 – present Editorial Board, Transfusion

2012 – present AABB Molecular Testing Standards Committee 2013 – 2016 ABMLI Validation Committee 2014 - present ISBT International Granulocyte Immunobiology Workshop Steering Committee 2015 – present ISTH Platelet Immunology SSC 2015 – present AABB Selection of Abstracts Program Unit 2016 - present ASH Scientific Committee on Transfusion Medicine 2016 - present Platelet Advisory Board, Ionis Pharmaceuticals

BOARD CERTIFICATIONS: 1986 - American Society of Clinical Pathologists Board Certification in Medical Technology, MT(ASCP) 1991 - American Society of Clinical Pathologists Board Certification, Specialist in Blood Banking (SBB) 2012 – Diplomat, American Board of Medical Laboratory Immunology D(ABMLI) 2014 – present - State of New York eCLEP permits as Assistant Director - Cellular Immunology – Non-malignant Leukocyte Immunophenotyping, Immunohematology


AWARDS/HONORS: Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists, University of California, San Diego, CA – 1990

National Blood Foundation Research Scholar, AABB - 1995 Tibor Greenwalt Award for outstanding staff leadership, BloodCenter of Wisconsin, Milwaukee, WI – 2005

PROFESSIONAL MEMBERSHIPS: American Society of Clinical Pathologists 1986 - present American Association of Blood Banks 1989 – present American Society of Hematology 2011 – present International Society of Blood Transfusion 2012 - present ICII 1996 – present International Society of Thrombosis & Hemostasis 2015 – present

NATIONAL INVITED LECTURES

1995 “Platelet Autoantibodies”, The Invitational Conference of Investigational Immunohematologists (ICII), Minneapolis, MN

2000 “Drug-induced thrombocytopenia (DITP): detection of drug-dependent platelet antibodies”. Short Topic, Immunology IV: Drug-Induced Thrombocytopenia, 53rd Annual Meeting of the American Association of Blood Banks, Washington, DC

2001 “Platelet Testing Techniques”, Complex Serological Investigations: AABB Immunohematology Reference Lab Conference, Chicago, IL

2001 “Platelets: Contributions from Wisconsin to Platelet Structure, Function, Genetics, Immunology, Collection, and Transfusion”, Wisconsin Association of Blood Banks 50th Anniversary Meeting, Milwaukee, WI.

2002 “Everything You Wanted to Know About Testing for NATP and HIT”, “Testing for TRALI”, Heart of America Association of Blood Banks 35th Annual Meeting, Kansas City, MO.

2002 “Neonatal Alloimmune Thrombocytopenia (NAT) in Cases of Assisted Reproductive Technology (ART)”. Advanced Case Studies and the Sally Frank Memorial Award Lecture (130-TC), Annual Meeting, American Association of Blood Banks, Orlando, FL

2003 “Neonatal Alloimmune Thrombocytopenia (NAT) in Cases of Assisted Reproductive Technology (ART)”. Advanced Case Studies and the Sally Frank Memorial Award Lecture (321-TC), Annual Meeting, American Association of Blood Banks, San Diego, CA

2004 “The Immunology and Genetics of Platelet Antigens”. DNA Technology in the Clinical Lab. 13th Annual Symposium on Molecular Pathology, Beaumont Pathology Conferences, William Beaumont Hospital, Royal Oak, MI

2004 “Platelet Antigens, Antibodies, and State of the Art Detection.” Platelets: Serology, Clinical and Potential Implications (310-TC). American Association of Blood Banks, Baltimore, MD

2005 “TRALI: Pathogenesis and Serology,” 27th Annual Fall Seminar, Wisconsin Association of Blood Banks, Wausau, WI

2006 “Clinical Testing for Heparin-Induced Thrombocytopenia (HIT).” 6th Annual ACL Laboratories Seminar Day, Milwaukee, WI.

2009 “Platelet Antibody and Antigen Testing in the Clinical Lab and Applications of the Results.” 36th annual Current Topics in Blood Banking Conference, University of Michigan, Ann Arbor, MI.

2009 “Platelet Antibody and Antigen Testing in the Clinical Lab and Applications of the Results.” ASCLS Annual Meeting Scientific Session, Chicago, IL.


2009 “Platelet Antibody and Antigen Testing in the Clinical Lab and How to Apply the Results.” GTI Diagnostics Technical Presentation and Reception. New Orleans, LA.

2010 “Platelet Antibody and Antigen Testing in the Clinical Lab and How to Apply the Results.” Ohio State Association of Blood Banks Meeting. Columbus, OH.

2011 “Clinical Utility of Platelet Antigen Bead Arrays in the Laboratory Diagnosis of Immune Platelet Disorders.” ANTIBODIES: Moving closer to personalized therapeutics and diagnostics. ABRF annual meeting, San Antonio, TX.

2011 “Laboratory Diagnosis of Immune Platelet Disorders,” ASCLS Meeting, Waukesha, WI. 2011 “Laboratory Diagnosis of Immune Platelet Disorders,” California Blood Bank Society and South

Central Assoc. of Blood Banks Joint Meeting, Las Vegas, NV. 2011 “Flow Cytometry in the Clinical Laboratory,” CLIA Midwest Consortia Meeting, Milwaukee, WI. 2011 “Laboratory Diagnosis of Immune Cytopenia Disorders,” Allergy/Immunology Grand Rounds, Medical

College of Wisconsin, Milwaukee, WI 2011 “Laboratory Diagnosis of Immune Platelet Disorders,” Illinois Association of Blood Banks Meeting,

OakBrook, IL 2011 "The Molecular Basis of HNA-3 and Its Importance in TRALI." AABB Meeting, San Diego, CA 2013 “Clinical Significance of HNA in TRALI,” AABB Public Workshop, “Current Perspectives on TRALI

Risk Reduction,” Bethesda, MD 2014 “Diagnostic Lab Testing for Immune Platelet Disorders,” ASCLS Meeting, Milwaukee, WI. 2014 “The Role of Antibody Testing in Support of a Clinical Diagnosis of Heparin-Indueced

Thrombocytopenia (HIT). Northwestern Memorial Hospital, Evanston, IL 2014 “Heparin-Induced Thrombocytopenia: The Role of Antibody Testing and the UAB Experience.”

University of Alabama Birmingham. 2014 “Unraveling the Mystery of HNA-3: a long journey and a complex protein.” Puget Sound Blood

Center, Seattle, WA 2016 “Laboratory Tests for Drug-Dependent Platelet Antibodies,” Ionis Pharmaceuticals, Inc., Carlsbad, CA 2017 “Drug-Induced Thrombocytopenia,” Land O’Lakes Annual Conference on Pharmaceutical Research &

Development, Division of Pharmacy Professional Development, University of Wisconsin, Madison, WI 2017 “Non-chemotherapy drug-induced neutropenia: key points to manage the challenges. Am Soc

Hematology Education Program, Congenital and Acquired Neutropenia, American Society of Hematology Annual Meeting, Atlanta, GA.

INTERNATIONAL INVITED LECTURES

1994 Speaker and Consultant, “Methods for Detection and Characterization of Platelet and Neutrophil

Antigens and Antibodies”, The Korean Society of Blood Transfusion and Seoul National University College of Medicine, Seoul, Korea

1998 Invited Speaker and Consultant, “Guidelines for the Detection and Identification of Platelet Antibodies in the Clinical Lab”, Metrix Laboratories, Mexico City, Mexico

1999 Invited Speaker and Consultant, “Guidelines for the Detection and Identification of Platelet Antibodies in the Clinical Lab”, Diagast Laboratoires, Frankfurt, Germany

1999 Invited Speaker and Consultant, “Development of Procedures for the Detection and Characterization of Platelet and Neutrophil Antigens and Antibodies”, Shen-Zhen Institute of Transfusion Medicine, Shen-Zhen, People’s Republic of China

2005 Invited Speaker, “Drug-Induced Immune Thrombocytopenia,” Third Annual Symposium on Transfusion Immunology and Related Topics, Canadian Blood Services, Research and Development, University of Toronto, Toronto, Canada.

https://www.ncbi.nlm.nih.gov/pubmed/29222255


2008 Invited Speaker, “CD36 (GPIV) – CD36 Deficiency and Immunization Against Platelet CD36,” International Symposium of Platelet Immunology, Chinese Society of Blood Transfusion, Nanning Institute of Transfusion Medicine and Municipal Government and Health Bureau, Nanning, China.

2010 “Application of Platelet Antibody Test Results in the Diagnosis of Immune Platelet Disorders and the Utility of Platelet Antigen Bead Arrays.” GTI Diagnostics. European Symposium on Platelet & Granulocyte Immunobiology, Beaune, France.

2010 “Class I HLA antibodies are the major cause of indeterminate serotonin release assay (SRA) test results in heparin-induced thrombocytopenia (HIT).” European Symposium on Platelet and Granulocyte Immunobiology, Beaune, France.

2012 “Laboratory Diagnosis of Immune Platelet Disorders,” 3rd Nanning International Symposium on Recent Progress in Platelet Immunology and Transfusion. Nanning, CHINA. Keynote Speaker.

2014 “Low Frequency HPA and Other Disorders Involving HPA.” European Symposium on Platelet and Granulocyte Immunobiology, Bad Homburg, Germany.

2015 “Diagnostic Lab Testing for Immune Platelet and Neutrophil Disorders: Future meets Past,” Keynote Presentation. Canadian Society for Transfusion Medicine Annual Conference, Winnipeg.

2015 “FACTS About Platelet Transfusion Refractoriness: Frequency, Aetiologies, Cost, Treatments. Canadian Society for Transfusion Medicine Annual Conference, Winnipeg.

2015 “Standardization of Testing for Drug-Dependent Platelet Antibodies,” Platelet Immunology SSC Meeting, ISTH Congress, Toronto, Canada

TEACHING ACTIVITIES:

1991 – Present Lecturer and Rotation Instructor SBB Program, BloodCenter of Wisconsin 2009 – 2011 Lecturer, Clinical Immunology, Clinical Laboratory Sciences Program, University of Wisconsin-Milwaukee 1999 – Present Rotational Instructor - Provide training and lectures on Platelet and Neutrophil Biology and Immune Disorders to Pathology Residents and Fellows from Medical College of Wisconsin, Transfusion Medicine Fellows and visiting Fellows and post docs, BloodCenter of WI GRANTS & OTHER SUPPORT: 1995 - 1997 Grant: 95-8 "Role of ABO Blood Group Incompatibility in the

Pathogenesis of Neonatal Alloimmune Thrombocytopenic Purpura" - National Blood Foundation, (Principal Investigator).

2001 – 2002 Grant: “Improved Diagnosis of Neonatal Alloimmune

Thrombocytopenia” – President’s Fund for Innovation, (Co-Principal Investigator).

2001-2003 “Study of the pathogenesis, diagnosis, and prevention of abciximab-

induced thromobocytopenia” – Funded Proposal, Centocor, Inc., Malvern, PA, (Co-Investigator).

2003-2004 Grant: “Improved Diagnosis of Neonatal Alloimmune

Thrombocytopenia” – President’s Fund for Innovation, (Co-Principal Investigator).


2007-2009 Subcontractor (agreement #10159-MB-02): Neutrophil Antibody and

Antigen Testing of Blood Donor Samples, “Retrovirus Epidemiology Donor Study-II (REDS-II)” – National Institutes of Health prime contract# N01-HB-57181, (Project Director).

2010 – 2011 Subcontractor (agreement #10159-MB-02): Neutrophil Antibody and

Antigen Testing of Blood Donor Samples, “Retrovirus Epidemiology Donor Study-II (REDS-II)” – National Institutes of Health prime contract# N01-HB-57181, (Project Director).

2012-2013 Grant: “Role of IgA and IgM Immunoglobulins in Heparin-induced

Thrombocytopenia and Thombosis.” Clinical and Translational Science Institute of Southeastern Wisconsin (Co-PI).

2014-2015 Grant: “Development of a New Diagnostic Assay for Heparin Induced

Thrombocytopenia: A Comparative Effectiveness Study” Clinical and Translational Science Institute of Southeastern Wisconsin (Co-PI).

PATENTS: 1996 U.S. Serial No. 5,585,243. Inventors - RH Aster and BR Curtis. METHOD OF

DETECTING CYTOPENIA THAT IS MEDIATED BY DRUG-DEPENDENT ANTIBODY BINDING TO BLOOD CELLS

2015 Patent No. US 9,017,958 B2. Inventor – Brian R. Curtis. METHOD OF

SIMULTANEOUS DETECTION OF HEPARIN-INDUCE IMMUNOGLOBULINS TYPES G, A, AND M.

GRANTS REVIEWED: October 2012: American Association for the Advancement of Science (AAAS) Research

Competitiveness Program, Washington State’s Life Science Discover Fund (LSDF), Washington September 2012: Austrian Science Fund (FWF), Biology and Medicine, Haus der Forschung January 2016: Pilot Translational and Clinical Studies Program, Medical College of Wisconsin

MANUSCRIPT REVIEWS: American Journal of Hematology, Arteriosclerosis Thrombosis and Vascular Biology, Archives of Gynecology and Obstetrics, Blood, Bone Marrow Transplantation, Clinical & Experimental Immunology, Experimental Hematology, Expert Reviews Molecular Diagnostics, Haematologica, Immunohematology, Journal of Laboratory & Clinical Medicine, Journal of Thrombosis & Hemostasis, Pediatric Drugs, The Protein Journal, Tissue Antigens, Transfusion, Transfusion Medicine, Transfusion Medicine Reviews, Vox Sanguinis ABSTRACT REVIEWS:

1991 – present AABB Annual Meeting 2014, 2015 European Hematology Association (EHA) Congress 2016 American Society of Hematology


PUBLICATIONS:

1. Ylagen ES, Curtis BR, Wildgen ME, Mass MD, Chaplin H. Invalidation of antiglobulin tests by high

thermal amplitude cryoglobulin. Transfusion 1990;30:154-157. 2. Green ED, Curtis BR, Issitt PD, Gutgsell NS, Roelke D, Farrar RP, Chaplin H. Inhibition of an anti-Pr

cold agglutinin by citrate present in commercial red cell preservative solutions. Transfusion 1990;30:267-270.

3. Curtis BR, Lamon J, Roelcke D, Chaplin H. Life-threatening antiglobulin test-negative acute

autoimmune hemolytic anemia due to a non-complement activating IgG1 κ cold antibody with Pra specificity. Transfusion 1990;30:838-843.

4. Ramos RR, Curtis BR, Chaplin H. A latex particle assay for platelet-associated IgG. Transfusion

1992;32:235-238. 5. Ramos RR, Curtis BR, Sadler JE, Eby CS, Chaplin H. Severe coombs negative autoimmune hemolytic

anemia with a high thermal amplitude IgG cold antibody. Autoimmunity 1992;12:149-154. 6. Ramos RR, Curtis BR, Duffy BF, Chaplin H. Low retention of WBC fragments by polyester fiber

leukocyte reduction platelet filters. Transfusion 1994;34:31-34. 7. Ramos RR, Curtis BR, Eby CS, Ratkin GA, Chaplin H. Fatal outcome in a patient with autoimmune

hemolytic anemia associated with an IgM bithermic anti-ItP. Transfusion 1994;34:427-431. 8. Curtis BR, McFarland JG, Wu GG, Visentin GP, Aster RH. Antibodies in sulfonamide-induced

immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Blood 1994;84:176-183.

9. Curtis BR and Aster RH. Incidence of the Naka-negative platelet phenotype in African Americans is

similar to that of Asians. Transfusion 1996;36:331-334. 10. Hessner MJ, Curtis BR, Endean DJ, Aster RH. Determination of neutrophil antigen gene

frequencies in five ethnic groups by polymerase chain reaction with sequence specific primers Transfusion 1996;36:895-899.

11. Gentilini G, Curtis BR, Aster RH. An antibody from a patient with ranitidine-induced

thrombocytopenia recognizes a site on glycoprotein IX that is a favored target for drug-induced antibodies. Blood 1998;92:2359-2365.

12. Hessner MJ, Shivaram SM, Dinauer DM, Curtis BR, Endean DJ, Aster RH. Neutrophil antigen

(FcRIIIB) SH gene frequencies in six racial groups. Blood 1999;93:1115-1116. 13. Price WR, Johnson ST, Curtis BR. Immunoglobulin isotype identification in red cell antibodies using

flow cytometry. Transfusion 1999;39:756-762.

14. Curtis BR, Edwards JT, Hessner MJ, Klein JP, Aster RH. Blood group A and B antigens are strongly expressed on platelets of some individuals. Blood 2000;96:1574-1581.


15. Aitman TJ, Cooper LD, Norsworthy JP, Wahid FN, Gray JK, Curtis BR, McKeigue PM,

Kwiatkowski D, Greenwood BM, Snow RW, Hill AV, Scott J. Malaria susceptibility and CD36 mutation. Nature 2000;405:1015-1016.

16. Curtis BR, Swyers J, Divgi A, McFarland JG, Aster RH. Thrombocytopenia after second exposure to

abciximab is caused by antibodies that recognize abciximab-coated platelets. Blood 2002;99:2054-2059.

17. Bougie DW, Wilker PR, Wuitschick ED, Curtis BR, Malik M, Levine S, Lind RN, Pereira J, Aster

RH. Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa. Blood 2002;100:2071-2076.

18. Curtis BR, Ali S, Aitman TJ, Ebert DD, Glazier A, Aster RH. Maternal isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature. Transfusion 2002;42: 1173-1179.

19. Brassard JA, Curtis BR , Cooper RA, Kupfer SR, Furgusen J, Kane M, Komoscar WJ, Kupfer S,

Maurath C, Swabb E, Aster RH. Acute thrombocytopenia in patients treated with the oral glycoprotein GPIIb/IIIa inhibitors xemilofiban and orbofiban: evidence for an immune etiology. Thromb Haemost

2002;88: 892-897. 20. Rezkalla SH, Hayes JJ, Curtis

BR, Aster RH. Eptifibatide induced acute profound thrombocytopenia

presenting as refractory hypotension. Catheter Cardiovasc Interv 2003;58:76-79. 21. Aljitawi OS, Krishnan K, Curtis BR, Bougie DW, Aster RH. Serologically documented loracarbef

(Lorabid)-induced immune thrombocytopenia. Am J Hematol 2003;73:41-43. 22. Davoren A, Curtis BR, Shulman IA, Mohrbacher AF, Bux J, Kwiatkowski BJ, McFarland JG, Aster

RH. TRALI due to granulocyte-agglutinating human neutrophil antigen-3a (5b) alloantibodies in donor plasma: a report of 2 fatalities. Transfusion 2003;43:641-645.

23. Rawal A, Sarode R, Curtis BR, Karandikar N, Friedman KD, Rogers ZR. Acquired Glanzmann’s

thrombasthenia as part of multiple autoantibody syndrome in a pediatric heart transplant patient. J Peds 2004;144:672-674.

24. Harrison CR, Curtis BR, McFarland JG, Huff RW, Aster RH. Severe neonatal alloimmune

thrombocytopenia caused by antibodies to human platelet antigen 3a (Baka) detectable only in whole platelet assays. Transfusion 2003;43:1398-1402.

25. Aster RH, Curtis BR, Bougie DA. Thrombocytopenia resulting from sensitivity to GPIIb/IIIa

inhibitors. Seminars in Thromb Haemost. 2004;30:569-577.

26. Curtis BR, Divgi A, Garritty M, Aster RH. Delayed thrombocytopenia after treatment with abciximab: A new clinical entity associated with the immune response to the drug. J Thromb Haemost 2004;2:985-992.


27. Davoren A, Saving K, McFarland MG, Aster RH, Curtis BR. Neonatal neutropenia and bacterial sepsis associated with placental transfer of maternal neutrophil-specific autoantibodies. Transfusion 2004;44:1041-1046.

28. Boylan B, Vipul R, Paddock C, Salacz M, Friedman KD, Curtis BR, Stapleton M, Newman DK, Chen

H, Kahn M, Newman PJ. JAQ-1/2/3-like ITP – a newly recognized clinical syndrome caused by autantibody-mediated clearance of the GPVI/FcR-chain complex from the human platelet surface. Blood 2004;104:1350-1355.

29. Davoren A, Curtis BR, Aster RH, McFarland JG. Human platelet antigen-specific alloantibodies

implicated in 1162 cases of neonatal alloimmune thrombocytopenia. Transfusion 2004;44:1220-1225.

30. Curtis BR, Bussel JB, Manco-Johnson M, Aster RH, McFarland JG. Fetal and neonatal alloimmune thrombocytopenia in pregnancies involving in vitro fertilization: a report of four cases. Am J Obstet

and Gynecol 2005;192:543-547. 31. Davoren A, Bussel JB, Curtis BR, Moghaddam M, Aster RH, McFarland JG. Prospective evaluation

of a new platelet glycoprotein (GP)-specific assay (PakAUTO) in the diagnosis of autoimmune thrombocytopenia (AITP). Am J Hematol 2005;78:193-197.

32. Curtis BR, Reno CK, Aster RH. Neonatal alloimmune neutropenia attributed to maternal immunoglobulin G antibodies against the neutrophil alloantigen HNA-1c (SH): a report of five cases. Transfusion 2005;45:1308-1313.

33. Peterson JA, Balthazor S, Curtis BR, McFarland JG, Aster RH. Maternal alloimmunization against the

rare platelet-specific antigen HPA-9b (Maxa) is an important cause of neonatal alloimmune thrombocytopenia. Transfusion 2005;45:1487-1495.

34. Curtis BR and Aster RH. Expression of ABH antigens on platelets. Blood 2006;107:842-843.

35. Curtis BR, Kaliszewski J, Marques MB, Saif MW, Nabell L, Blank J, McFarland JG, Aster RH. Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin. Am J Hematol 2006;81:193-198.

36. Curtis BR, McFarland JG. Mechanisms of transfusion-related acute lung injury (TRALI): Anti-

leukocyte antibodies. Crit Care Med (May Suppl) 2006;34:S118-123. 37. RH Aster, BR Curtis, DW Bougie, S Dunkley, A Greinacher, TE Warkentin, BH Chong.

Thrombocytopenia associated with the use of GPIIb/IIIa inhibitors: position paper of the ISTH working group on thrombocytopenia and GPIIb/IIIa inhibitors. J Thromb Haemost 2006;4:678-679.

38. Silliman CC, Curtis BR, Kopko P, Khan SY, Kelher M, Shuler R, Sannoh B, Ambruso DR. Donor

antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model. Blood

2007;109:1752-1755. 39. Von Drygalski A, Curtis

BR, Bougie DW, McFarland JG, Ahl S, Limbu I, Baker KR, Aster RH.

Vancomycin-induced immune thrombocytopenia. N Engl J Med 2007;356:904-910.


40. Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton

PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nature Medicine 2007;13:1086-1095.

41. Curtis BR, Fick A, Lochowicz A, McFarland JG, Ball RH, Peterson, JA, Aster RH. Neonatal

alloimmune thrombocytopenia (NATP) associated with maternal fetal incompatibility for blood group B. Transfusion 2008;48:358-364.

42. Berger-Achituv S, Ellis MH, Curtis BR, Wolach B. Transfusion-related acute lung injury following

administration of intravenous anti-D. Am J Haematol 2008;83:676-678.

43. Curtis BR. Genotyping for human platelet alloantigen polymorphisms: applications in the diagnosis of alloimmune platelet disorders (Review). Semin Thromb Hemost 2008;34:539-548.

44. ISBT Working Party on Granulocyte Immunobiology; (P. Bierling, J. Bux, B. Curtis, B. Flesch, l. Fung, G. Lucas, M. Macek, E. Muniz-Diaz, l. Porcelijn, A. Reil, U. Sachs, R. Schuller, N. Tsuno, M. Uhrynowska, S. Urbaniak, N. Valentin, A. Wikman & B. Zupanska). Recommendations of the ISBT Working Party on Granulocyte Immunobiology for leucocyte antibody screening in the investigation and prevention of antibody-mediated transfusion-related acute lung injury. Vox Sang 2009;96:266-269.

45. James E, Podoltsev N, Salehi E, Curtis BR, Saif MW. Oxaliplatin-induced Immune

Thrombocytopenia (OITP): Another Cumulative Dose Dependent Side Effect. Clinical Colorectal

Cancer 2009;8 (4):220-224. 46. Akhatri M, Curtis B, Waller E. Autoimmune neutropenia in adults. (Review). Autoimmunity Reviews

2009;9:62-66. 47. Aster RH, Curtis BR, McFarland JG, Bougie DW. (Review). Drug-induced Immune

Thrombocytopenia: Pathogenesis, Diagnosis and Management. J Thromb Haemost 2009; 7(6):911-8.

48. Curtis BR and McFarland JG. Detection and identification of platelet antibodies and antigens in the clinical laboratory. (Review) Immunohematology 2009;25(3):125-135.

49. Rousan, TA Rousan, Aldoss IT, Cowley, BD, Curtis BR, Bougie DW, Aster, RH, George JN.

Recurrent acute thrombocytopenia in the hospitalized patient: Sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia. .Am J Haematol 2010;85(1):71-74.

50. Peterson JA, Gitter ML, Kanack A, Curtis BR, McFarland JG, Bougie D, Aster R. New low-

frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia. Transfusion 2010;50(2):324-333.

51. Bautista M, Stevens TW, Chen C, Curtis BR, Aster R, Hsueh C. Hypersensitivity reaction and acute

immune-mediated thrombocytopenia from oxaliplatin: report of two cases and review of literature. Journal of Hematology & Oncology 2010;3:12.


52. Curtis BR, Cox NJ, Sullivan MJ, Konkashbaev A, Bowens K, Hansen K, Aster RH. The neutrophil alloantigen HNA-3a (5b) is located on choline transporter- like protein 2 (CTL2) and appears to be encoded by an R>Q154 amino acid substitution. Blood 2010;115:2073-2076.

53. Czuchlewski DR, Brackney M, Ewers C, Manna J, Fekrazad MH, Martinez A, Nolte K, Hjelle B,

Rabinowitz I, Curtis BR, McFarland JG, Baumbach J, Foucar K. Clinicopathologic features of agranulocytosis in the setting of levamisole-tainted cocaine. Am J Clin Path 2010;133:466-472.

54. Ahmad Wehbe, Birgir Johannsson, Thomas J. Raife, Michelle Bleile, Adam Bell, Brian R. Curtis,

Thorvardur R. Halfdanarson. Severe autoimmune neutropenia associated with acute autoimmune hepatitis. Int J Hematol 2010 May;91(4):673-8.

55. Peterson JA, Gitter M, Pietz B, Bellissimo D, Curtis BR, Aster RH. A third allele of the HPA-5 (Br)

alloantigen system identified investigating a case of neonatal thrombocytopenia. Transfusion 2010; 50(8):1855-6.

56. Reese JA, Li X, Hauben M, Aster RH, Bougie DW, Curtis BR, George JN, Vesely SK. Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods. Blood

2010;116(12):2127-2133.

57. GG Wu, C Kaplan, BR Curtis, HA Pearson. Report on the 14th International Society of Blood Transfusion Platelet Immunology Workshop. Vox Sang 2010;99:375-381.

58. Saw, CL, Syzkoluk H, Curtis BR, Nickerson P, Goldman M. Two cases of platelet-transfusion

refractoriness associated with anti-CD36. Transfusion 2010;50(12):2638-42.

59. Tomoya Hayashi, Etsuko Amakishi, Nobuki Matsuyama, Kazuta Yasui, Rika A Furuta, Yuji Hori, Shigenori Tanaka, Brian R. Curtis, Masayasu Inoue, Fumiya Hirayama. Detection of antibodies reactive with human platelet antigens 15a and 15b using recombinant human CD109 produced in stably transduced cell lines. Brit J Haematol 2010;151(4):402-404.

60. Gottschall J, Triulzi D, Curtis BR, Kakaiya R, Busch M, Norris P, Glynn S, Carrick D, Wright, D, Kleinman S. The frequency and specificity of Human Neutrophil Antigen antibodies in a blood donor population. Transfusion 2011;51(4):820–827.

61. Curtis BR, Sullivan MJ, Holyst T, Szabo A, Bougie, DW, Aster RH. A 36-mer peptide from CTL2 containing arginine 154 is recognized by a subset of HNA-3a alloantibodies implicated in TRALI. Transfusion 2011; ;51:2168-2174.

62. Lochowicz, AJ and Curtis BR. Clinical applications of platelet antibody and antigen testing. Lab Med 2011;42 (11):687-692.

63. Julie A. Peterson, Shannon M. Pechauer, Maria L. Gitter, Adam Kanack, Brian R. Curtis, Jeff Reese,Vasudeva M. Kamath, Janice G McFarland, and Richard H. Aster. New platelet glycoprotein polymorphisms causing maternal immunization and neonatal alloimmune thrombocytopenia. Transfusion 2012;52(5):1117-1124.

64. Adam Kanack, Julie A Peterson, Mia Sullivan, Daniel W Bougie, Brian R Curtis, Richard H Aster.


Full-length recombinant choline transporter-like protein 2 containing arginine 154 reconstitutes the epitope recognized by HNA-3a antibodies. Transfusion 2012;52(5):1112-6.

65. Roos Achterbergh, Eric Vermeer, Brian Curtis, Leendert Porcelijn, Richard H Aster, Wendy Deenik,

Karin Daemen-Gubbels. Thrombocytopenia in a nutshell. Lancet 2012;379:776.

66. Brian R. Curtis. Future preventive and therapeutic targets for transfusion-related acute lung injury. Current Pharmaceutical Design 2012;18:3285-3292.

67. Julie A. Peterson, Shannon M. Pechauer, Maria L. Gitter, Aniko Szabo, Brian R. Curtis, Richard H. Aster. The human platelet antigen (HPA)-21bw is relatively common among Asians and is a potential trigger for neonatal alloimmune thrombocytopenia. Transfusion 2012;52(4):915-916.

68. Krista Bowens, Mia Sullivan, Brian R. Curtis. Determination of neutrophil alloantigen HNA-3a and

HNA-3b genotype frequencies in six racial groups by high-throughput 5’ exonuclease assay. Transfusion 2012 Nov;52(11):2368-2374.

69. GM Thomas, C Carbo, BR Curtis, K Martinod, IB Mazo, D Schatzberg, SM Cifuni, TA Fuchs, UH

von Andrian, JH Hartwig, RH Aster, DD Wagner. Extracellular DNA traps are associated with pathogenesis of TRALI in humans and mice. Blood 2012;119:6335-6343.

70. JG McFarland, AJ Lochowicz, RH Aster, BT Chappell, BR Curtis. Improving the specificity of the PF4 ELISA in diagnosing heparin-induced thrombocytopenia. Am J Hematol 2012;87:776–781.

71. Henricus J Vermeer, Roos Achterbergh, Leendert Porcelijn, Richard H Aster, Wendy Deenik,

Catharine Damen-Gubbels, Brian R Curtis. Watch the Walnuts: Severe Immune Thrombocytopenia after Consumption of English Walnuts. Ned Tijdschr Klin Chem Labgeneesk 2012; 37: 232-233.

72. J Peterson, JG McFarland, BR Curtis, RH Aster. Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnosis and Management. Br J Haematol 2013;161:3-14.

73. A Singla, M Sullivan, JR Bartholomew, S Kapadia, RH Aster, BR Curtis,. Protamine-induced thrombocytopenia: a new mechanism for immune-mediated platelet destruction. Transfusion 2013;53(10):2158-2163.

74. JA Peterson, A Knack, D Nayak, D Bougie, JG McFarland, BR Curtis, RH Aster. Prevalence and clinical significance of low avidity HPA-1a antibodies in women exposed to HPA-1a during pregnancy. Transfusion 2013 Jun;53(6):1309-1318.

75. Reese JA, Nguyen LP, Buchanan GR, Curtis BR, Terrell DR, Vesely SK, George JN.. Drug-induced

thrombocytopenia in children. Pediatr Blood Cancer 2013;60(12):1975-81.

76. Brian R. Curtis and Janice G. McFarland. Human platelet antigens – 2013. Vox Sang 2014;106:93–102.

77. Barry C. Mirtsching, James N. George, Richard H. Aster, Brian R. Curtis. Irinotecan-induced immune thrombocytopenia. Am J Med Sci 2014;347(2):167-169.


78. Suh SE, Jang MJ, Chong SY, Aster RH, Curtis BR, Oh D. A case of oxaliplatin-induced immune-mediated thrombocytopenia. Blood Res. 2014 Mar;49(1):61-4.

79. Julie A Peterson, Maria Gitter, Daniel W Bougie, Shannon Pechauer, Kathie A. Hopp, Brad Pietz, Aniko Szabo, Janice G McFarland, Brian R Curtis, and Richard H Aster. Low frequency human platelet antigens (HPA) as triggers for neonatal alloimmune thrombocytopenia (NAIT). Transfusion

2014;54(5):1286-1293. 80. Kriti Mittal, Michael J McNamara, Brian R Curtis and Keith R McCrae. Persistence of Antiplatelet

Antibodies in Oxaliplatin Induced Immune Thrombocytopenia. JRSM Open 2014;5(6):1-3.

81. Daniel W Bougie, Julie Peterson, Adam Kanack, Brian R Curtis, Richard H Aster. TRALI associated HNA-3a antibodies recognize complex determinants on choline transporter-like protein 2 (CTL2). Transfusion 2014;54:3208-3215.

82. Khandelwal P, Davies SM, Grimley MS, Jordan, Curtis BR, Jodele S, Marsh RA, Filipovich AJ. Bortezomib for refractory autoimmunity in pediatrics. Biol Blood Marrow Transplant. 2014;10:1654-1659.

83. Brian R. Curtis. Drug-induced immune thrombocytopenia: incidence, clinical features, laboratory

testing, and pathogenic mechanisms. Immunohematology 2014;30(2):55-65.

84. Brian R. Curtis. Drug-induced immune neutropenia/agranulocytosis. Immunohematology

2014:30(2):95-101.

85. Anand Padmanabhan, Curtis G. Jones, Daniel W. Bougie, Brian R. Curtis, Janice G. McFarland, Demin Wang and Richard H. Aster. Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis. Blood 2015;125:155-161.

86. Mia J. Sullivan, Julie Peterson, Janice G. McFarland, Daniel Bougie, Richard H. Aster, Brian R.

Curtis. A new low frequency alloantigen (Khab) located on platelet glycoprotein IIIa as a cause of maternal sensitization leading to neonatal alloimmune thrombocytopenia. Transfusion 2015;55:1584-1585.

87. Walz, Amy; Lenzen, Alicia; Curtis, Brian, Canner, Jason; Schneiderman, Jennifer. Use of stem cell transplantation for moderate-severe Glanzmann Thrombasthenia. Platelets 2015;Nov;26(7):702-704.

88. Masanori Hayashi, John J. Strouse, Michael Veltri, Brian R. Curtis, Clifford M. Takemoto. Immune

Thrombocytopenia due to Trimethoprim-Sulfamethoxazole; under recognized risk in children? Pediatr

Blood Cancer 2015;May;62(5):922-923. 89. DM Arnold, BR Curtis, T Bakchoul. Recommendations for standardization of laboratory testing for

drug-induced thrombocytopenia. J Thromb Haemost 2015;Apr;13(4):676-678. 90. Jessica A. Reese, Daniel W. Bougie, Brian R. Curtis, Deirdra R.Terrell, Sara K. Vesely, Richard H.

Aster, James N. George. Drug-induced thrombotic microangiopathy: Experience of the Oklahoma registry and the BloodCenter of Wisconsin. Am J Hematol 2015;90(5):406-410.


91. Anand Padmanabhan, Curtis G. Jones, Daniel W. Bougie, Brian R. Curtis, Janice G. McFarland, Demin Wang, and Richard H. Aster. A PF4-dependent CD62p expression assay selectively detects serotonin releasing antibodies in patients suspected of HIT. Thromb Haemost 2015; Nov 25;114(6):1322-3.

92. Brian R. Curtis. Recent progress in understanding the pathogenesis of fetal and neonatal alloimmune

thrombocytopenia. Br J Haematol 2015; 171, 671–682. 93. Brian R Curtis, Ashley Roman, Mia Sullivan, Cindy Raven, Judy Larison, LeeAnn Weitekamp. Two

Cases of Maternal Alloimmunization Against Human Neutrophil Alloantigen-4b, One Causing Severe Alloimmune Neonatal Neutropenia. Transfusion 2016;56:101–106.

94. Anand Padmanabhan, Curtis G. Jones, Brian R. Curtis, Daniel W. Bougie, Mia J. Sullivan, Namrata

Peswani, Jancie G. McFarland, Daniel Eastwood, Demin Wang, Richard H. Aster. A novel PF4-dependent platelet activation assay identifies patients likely to have heparin-induced thrombocytopenia/thrombosis (HIT). Chest 2016;150(3):506-15.

95. Nanyan Zhang, Huiying Zhi, Brian R Curtis, Sridhar Rao, Chintan Jobaliya, Mortimer Poncz,

Deborah L. French, Peter Newman. Designer Platelets:CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. Blood 2016;127(6):675-680.

96. Brigitte Flesch, Brian R. Curtis, Masja de Haas, Geoff Lucas, Ulrich Sachs. Update on the

nomenclature of human neutrophil antigens and alleles. Transfusion 2016; Jun;56(6):1477-9. doi: 10.1111/trf.13575.

97. Gavin Falk, Krista Bowens, Daniel Bougie, Brian R Curtis, and Richard H Aster. An unexpected development after surgery - post-transfusion purpura! Am J Hematol 2016:Aug 91(8):848-51. doi: 10.1002/ajh.24414.

98. Krista Metzner, Julie Bauer, Heather Ponzi, Allison Ujcich, Brian R. Curtis. Detection and identification of platelet antibodies using a sensitive multiplex assay system - Platelet Antibody Bead Array (PABA). Transfusion 2017;Jul;57(7):1724-1733.

99. Mia J. Sullivan, Randy Kuhlmann, Julie Peterson, Brian R. Curtis. A new low frequency alloantigen (Domb) located on platelet glycoprotein IIIa as a cause of maternal sensitization leading to neonatal alloimmune thrombocytopenia. Transfusion 2017;Jul;57(7):1847-1848.

100. Anand Padmanabhan, Curtis G. Jones, Shannon Pechauer, Brian R. Curtis, Daniel W. Bougie, Mehraboon, Barbara Bryant, Kack Alperin, Thomas Delougehry, Kevin Mulvey, Dhakal Binod, Renren Wen, Demin Wang, Richard H. Aster. Intravenous immunoglobulin for treatment of severe refractory heparin-induced thrombocytopenia. Chest 2017;Sep;152(3):478-485.

101. Jones, Curtis; Pechauer, Shannon; Curtis, Brian; Bougie, Daniel; Irani, Mehraboon; Dhakal, Binod; Pierce, Brenda; Aster, Richard; Padmanabhan, Anand. A PF4-dependent platelet activation assay (PEA) facilitates early detection of pathogenic HIT antibodies. Chest 2017;Oct;152(4):e77-e80. doi: 10.1016/j.chest.2017.06.001.

http://www.ncbi.nlm.nih.gov/pubmed/27159228

http://www.ncbi.nlm.nih.gov/pubmed/27159228


102. Curtis BR. Non-chemotherapy drug-induced neutropenia: key points to manage the challenges. Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):187-193. doi: 10.1182/asheducation-2017.1.187.

103. Paul F. Lindholm, Glenn Ramsey, Brian R. Curtis, Jonathan Fryer, Hau C. Kwaan Severe thrombocytopenia in a patient following liver transplantation caused by HPA-1a antibodies produced by the liver donor. Am J Hematol 2018;Jan;93(1):150-153. doi: 10.1002/ajh.24944

104. Curtis SA, Curtis BR, Lee AL, Hendrickson JE, Lacy J, Podoltsev NA. A patient with oxaliplatin immune-induced syndrome (OIIS) who also developed leucovorin and palonetron-associated thrombocytopenia. Hematology 2017 Dec 28:1-4. doi: 10.1080/10245332.2017.1419600. [Epub ahead of print]

105. Jones CG, Pechauer SM, Curtis BR, Bougie DW, Aster RH, Padmanabhan A. IgG in normal plasma

inhibits HIT antibody-mediated platelet activation: implications for plasma exchange in HIT. Blood 2017 Dec 19. pii: blood-2017-08-803031. doi: 10.1182/blood-2017-08-803031. [Epub ahead of print]

106. Curtis, BR, Hsu, Y-MS, Podoltsev N, Lacy J, Curtis S, DeSimone R, Samuel MS, Bougie DW, Aster RH. Patients undergoing cancer chemotherapy with oxaliplatin are at risk for thrombocytopenia caused by multiple drug-dependent antibodies. Blood 2018; manuscript submitted.

107. Aye Myat Myat, Thinn, Zhengli Wang, Dongwen Zhou, Yan Zhao, Brian R. Curtis, Jieqing Zhu. A

single-chain β3 integrin folds into a bent conformation in solution but extends on the cell surface. EMBO J 2017; manuscript submitted.

108. Narayanan P, Shen, L, Curtis BR, Bourdon M, Nolan JP, Zhou F, Greenlee S, Hoffmaster C, Burel S, Witztum J,Engelhardt J, Henry S. Investigation into the mechanism(s) that leads to platelet decreases in cynomolgus monkeys during administration of ISIS-104838, a 2ʹ-MOE-modified antisense oligonucleotide. Tox Sci 2017; submitted.

BOOK CHAPTERS:

1. BR Curtis. Drug Induced thrombocytopenia (DITP): Detection of drug-dependent platelet antibodies. Immunology IV: Drug-Induced Thrombocytopenia. In The Compendium, The 53rd Annual Meeting of the American Association of Blood Banks, Washington, DC, 2000, pg. 306-311.

2. BR Curtis, JL Gottschall, JG McFarland. Platelet immunology and alloimmunization. In: Rossi’s

Principles of Transfusion Medicine. TL. Simon, WH. Dzik, E. Snyder, CP. Stowell, RG Strauss (eds.), Lippincott Williams & Wilkins, Philadelphia, 3rd edition, pp. 203-217, 2002.

3. MJ Hessner and BR Curtis. Prenatal genotyping for identification of fetuses at risk for immune

cytopenic disorders. In: Molecular Diagnostics for the Clinical Laboratorian. W.B. Coleman and G.J. Tsongalis (editors), Humana Press, 2nd edition, pp. 329-339, 2005.





4. BR Curtis and JG McFarland. Platelet immunology and alloimmunization. In: Rossi’s Principles of Transfusion Medicine. TL. Simon, WH. Dzik, E. Snyder, CP. Stowell, RG Strauss (eds.), Lippincott Williams & Wilkins, Philadelphia, 4th edition, pp. 168-186, 2009. Published Online : 4 MAR 2009, DOI: 10.1002/9781444303513.ch11

5. BR Curtis. Platelet and Granulocyte Antigens and Antibodies. In: Technical Manual. MK Fung, BJ Grossman, CD Hillyer, CM Westhoff (eds.), AABB, Bethesda, 18th edition, Chptr 18, pp. 453-474 , 2014.

6. BR Curtis. Platelet and Neutrophil Antigens. In: Practical Transfusion Medicine. Michael F. Murphy, Derwood H. Pamphilon, Nancy M. Heddle, David Roberts, Mark Yazer (editors), John Wiley & Sons, Ltd., Sussex, UK, 5th edition, Chapter 5, pp. 45-59, 2017.

7. R. Vassallo and Brian R. Curtis. Platelet and Granulocyte Antigens and Antibodies. In: Technical Manual. MK Fung, AF Eder, SL Spitalnik, CM Westhoff (eds.), AABB, Bethesda, 19th edition, Chapter 15, pp. 413-454 , 2017.

EDITORIALS:

1. BR Curtis. The Evolving Use of Bead Arrays for Platelet Antibody Detection. Transfusion 2010;50:1406-1407.

2. BR Curtis. Another Blow to Leukocyte Antibody-Mediated TRALI. Expert Rev Hematol 2010;3(4):373-375.

3. BR Curtis. Is TRALI Caused by HLA Class II too? Blood 2011 Jan 13;117(2):378-9.

ELECTRONIC MEDIA:

1. Chaffin, Joe. Blood Bank Guy. 027: NAIT with Brian Curtis by Joe | Feb 13, 2017 | BBGuy Podcast, http://www.bbguy.org/2017/02/13/027/

2. BR Curtis. AABB Webcasts. Immunohematology Boot Camp: Platelet Immunology. May 10, 2017. Master Program Number: 17EL-133. http://www.aabb.org/development/elearning/Pages/133.aspx

ABSTRACTS (Abstracts included only for work not published in manuscript form):

1. Curtis BR, Chaplin H. A rapid radioimmunoassay (RIA) for platelet-associated IgG, IgM, C3d. Abstract. Transfusion 30 (suppl.), 1989.

2. Curtis BR, Silva VA, Marlo DJ, Chaplin H. A simple method for counting white blood cells (WBC) in

low-WBC platelet products. Abstract. Book of Abstracts. American Association of Blood Banks/International Society of Blood Transfusion Joint Congress, Los Angeles, CA, 1990.

http://www.bbguy.org/author/joechaffin/

http://www.bbguy.org/category/podcast/

http://www.bbguy.org/2017/02/13/027/

http://www.aabb.org/development/elearning/Pages/133.aspx


3. Curtis BR, Ramos RR, Chaplin H. Electron microscopic cytochemistry and platelet-associated IgG measurements: Investigation of a possible storage lesion in 5-day stored platelet products. Abstract. Transfusion 31 (Suppl.), 1991.

4. Curtis BR, McFarland JG, Aster RH. Enhanced detection of antibodies (DDAb) responsible for drug-

induced thrombocytopenia. Transfusion 33 (Suppl.), 1993.

5. Wu GG, Curtis BR, Shao YL, Aster RH. Analysis of quinine-dependent neutrophil-reactive antibodies in patients with quinine-induced hemolytic uremic syndrome (HUS) and quinine-induced thrombocytopenia by flow cytometry and immunoprecipitation. Transfusion 33 (Suppl.), 1993.

6. Wu GG, Curtis BR, Shao YL, Aster RH. Investigation of human neutrophil antigens with a new

nonradioactive immunoprecipitation technique: characterization of NB1 and NB2 antigenic targets. Transfusion 33 (Suppl.), 1993.

7. Osbourne SE, Johnson ST, Weitekamp LA, Curtis BR, Aster RH. Enhanced detection of drug-

dependent antibodies reacting with untreated red blood cells in the presence of drug. Abstract. Transfusion 34 (Suppl.), 1994.

8. Shreck C, Collins J, Curtis BR, Aster R, McFarland JG. Laboratory investigation of thrombocytopenia

related to rarely implicated drugs. Blood 84 (Suppl. 1):186a, 1994.

9. Curtis BR, PJ Hansen, RH Aster. An autoantibody against platelet glycoprotein IIb/IIIa that recognizes citrate but not EDTA platelets. Abstract. Transfusion 37 (Suppl.), 1997.

10. Curtis BR, SF Donnelly, PD Mintz, VX Boos, SL Hetzel, RH Aster. Platelet transfusion refractoriness

in an african american patient due to anti-Naka. Abstract. Transfusion 37 (Suppl.), 1997.

11. BR Curtis, DD Ebert, MJ Hessner, RH Aster. Neonatal alloimmune neutropenia due to anti-SH. Abstract. The 5th European Symposium on Platelet and Granulocyte Immunobiology, S’AgaroGirona, Spain. 1998.

12. BR Curtis, DD Ebert, M Torres, RH Aster. Prolonged, severe neutropenia in an infant due to a high-

titer NA2 alloantibody. The 5th European Symposium on Platelet and Granulocyte Immunobiology, S’Agaro, Girona, Spain. 1998.

13. Bougie, D, Wilker PR, Curtis BR, Aster RH. Drug-induced immune thrombocytopenia (DITP)

induced by ibuprofen. Blood (suppl. 1) 92, 1998.

14. Lozano ML, Curtis BR, Hansen RM, Bayliss K, Peterson JA, Aster RH. A GPIIb/IIIa-specific autoantibody from a patient with acquired amegakaryocytic thrombocytopenia appears to be the first example of a human ligand mimetic immunoglobulin. Blood (suppl. 1) 92, 1998.

15. Johnson ST, Curtis BR, Fueger JT, Gottschall JL. IgA warm autoantibody detected by flow cytometry.

Transfusion (suppl.) 39, 1999.


16. Curtis BR, McFarland JG, Harrison CR, Ebert DD, Aster RH. Some anti-Baka (HPA-3A) antibodies react with intact platelets but fail to react in immunoprecipitation and solid phase assays. Transfusion (suppl. 1) 40, 2000.

17. Curtis BR, Ebert DD, Hessner MJ, Aster RH. Neonatal alloimmune neutropenia due to anti-SH.

Transfusion (suppl. 1) 40, 2000.

18. Hessner MJ, Ekman GC, Ebert DD, Wu GG, Aster RH, Curtis BR. Neutrophil antigen (FCRIIIB) SH gene is observed in association with both NA1 and NA2. Transfusion (suppl. 1) 40, 2000.

19. McFarland JG, Curtis BR, Friedman KD, Aster RH. Platelet alloantigen incompatibilities implicated

in 975 cases of suspected neonatal alloimmune thrombocytopenia (NATP). Blood (suppl. 1) 98;449a, 2001.

20. Gershan JA, Visentin GP, Curtis BR, Aster RH. Molecular basis for high expression of A1 antigen on platelets of some normal individuals. Blood (suppl. 1) 98;708a, 2001.

21. Curtis BR, Swyers J, Divgi A, McFarland JG, Aster RH. Delayed thrombocytopenia after abciximab is caused by neosensitization against murine sequences in the chimeric Fab molecule. The 7th European Symposium on Platelet, Granulocyte, and Red Cell Immunobiology, Programme and Abstracts (pp. 130), Belgirate, Lago Maggiore, Italy, 2002.

22. Aster RH, Bougie DW, Curtis BR. Immune thrombocytopenia (TP) resulting from sensitivity to

fibrinogen receptor antagonists. The 7th European Symposium on Platelet, Granulocyte, and Red Cell Immunobiology, Programme and Abstracts (pp. 52), Belgirate, Lago Maggiore, Italy, 2002.

23. Peterson J, Balthozor S, Curtis BR, McFarland JG, Aster RH. Examination of the incidence of “rare”

platelet alloantigen incompatibility in unresolved cases of neonatal alloimmune thrombocytopenic purpura (NATP). The 7th European Symposium on Platelet, Granulocyte, and Red Cell Immunobiology, Programme and Abstracts (pp. 43), Belgirate, Lago Maggiore, Italy, 2002.

24. Afenyi-Annan A, Judd WJ, Curtis BR. Cefotetan-induced immune mediated hemolysis complicated

by thrombocytopenia: alloimmune or thrombotic? Transfusion (suppl) 42: 46S, 2002.

25. Peterson JA, Balthazar SM, Curtis BR, Aster RH. “Rare” platelet alloantigen incompatibility should be examined in unresolved cases of neonatal alloimmune thrombocytopenic purpura (NATP). Blood suppl.1,100:58a, 2002.

26. Talano JM, Johnson ST, Friedman KD, Ilstrup SJ, Curtis BR, Scott JP, Gottschall JL. Serologic

characteristics of three cases of IgA mediated autoimmune hemolytic anemia (AIHA) confirmed by flow cytometry. Blood suppl. 1, 100:283a, 2002.

27. Curtis BR, Lochowicz AJ, Salman E, Aster RH. First Neutrophil Alloantigen (Lob) Identified on NB1 (CD177) in a Case of Neonatal Alloimmune Neutropenia (NAN). Blood 2003;102:557a.

28. Lankiewcz MW, Talano JM, Johnson ST, Scott JP, Curtis BR, Gottschall JL. IgA Mediated Delayed

Hemolytic Transfusion Reaction/Hyperhemolysis Syndrome in a Patient With Sickle Cell Disease. Blood 2003;102:560a.


29. Peterson JA, Balthozour SM, Curtis BR, McFaralnd JG, Aster RH. Maternal Immunization Against

“Rare” Platelet-Specific Alloantigens is an Important Cause of Neonatal Alloimmune Thrombocytopenia. Blood 2003;102:86a.

30. Fueger JT, Gottschall JL. Curtis BR, Johnson ST. DAT Negative Hemolytic Anemia – the role of

enhanced techniques. Transfusion (supplement) 2003;43:10.

31. Curtis BR, Couture M, Aster RH. Severe neutropenia and agranulocytosis caused by IgM phenytoin-dependent neutrophil antibodies in a patient with chronic renal failure. The 8th European Symposium on Platelet and Granulocyte Immunobiology, Final Program and Abstracts (COM09), Rust, Burgenland, Austria, 2004.

32. Curtis BR, McFarland JG, Bellissimo D, Aster RH, Peterson J. Neonatal thrombocytopenia (NATP)

possibly caused by maternal immunization against a third allele of HPA-5 (HPA-5c, Brc). The 8th European Symposium on Platelet and Granulocyte Immunobiology, Final Program and Abstracts (COM15), Rust, Burgenland, Austria, 2004.

33. Curtis BR, Lochowicz AL, Salman E, Aster RH. First neutrophil alloantigen (Lob) identified on NB1

(CD177). The 8th European Symposium on Platelet and Granulocyte Immunobiology, Final Program and Abstracts (POS32), Rust, Burgenland, Austria, 2004.

34. Curtis BR, Graminske S, Lochowicz AJ, Castro E, Lin, L, Flament J, Metzel P, Corash L.

Conservation of human platelet antigen (HPA) immunologic identity after photochemical treatment of platelet components with amotosalen (S-59) and UVA light. Transfusion (supplement) 2005;45:29A.

35. Punzalan RC, Hanson SJ, Ghanayem N, Curtis BR, Murkowski K, Havens PL, McFarland JG.

Prevalence of heparin-dependent platelet antibodies in children after cardiopulmonary bypass surgery. Blood 2005;106:

36. Curtis BR, Bougie D, Duelge S, Birenbaum J, McFaralnd JG, Cohen A, Aster RH. Drug-induced

immune thrombocytopenia resulting form sensitivity to the chemotherapeutic drug 17-AAG. Vox Sang

2006;(suppl.2)91:23.

37. GM Beyer, MA Martin, T Nash, BR Curtis, Harrison CR. Platelet Refractoriness Secondary to Platelet Specific Antibody Against Glycoprotein IV (CD36). Transfusion (supplement) 2007;47:196A.

38. William R Broderick, Amir A Toor, Brian R Curtis, Tulio Rodriguez, Scott E Smith, Patrick J Stiff,

Phillip J DeChristopher. Refractory Thrombocytopenia Due To Allo-Immune Anti-CD36 Complicating Unrelated Donor Bone Marrow Transplant In A CD36-Negative Recipient. Blood 2007;110 (suppl).

39. D Triulzi, R Kakaiya, S Kleinman, M Busch, P Norris, D Carrick, W Steele, B Curtis, R de Castro,

and G Schreiber for the NHLBI Retrovirus Epidemiology Donor Study-II. Human neutrophil antibody prevalence in US blood donors. Transfusion 2008 (suppl);48:1A.

40. S Santi, D Boyer, S Chance, B Curtis. Large scale screening of blood donors for HLA antibodies using

a high-throughput ELISA assay system. Transfusion 2008 (suppl);48:42A.


41. McFarland JG, Curtis BR, Lochowicz AJ, Gough P, Jahn L, Aster RH. Correlation of PF4 ELISA results and clinical likelihood of HIT – Can we improve on specificity? Blood 2008 (suppl);112:3423.

42. Gheller-Rigoni AI, Adamiak TR, Curtis BR, Hintermeyer MK, Grossman WJ. Autoimmune

Neutropenia Presenting with Severe, Life-threatening Infections. J Allergy Clin Immunol 2009; 123(2):S316.

43. Kathleen Puca, Janice McFarland, Amber Krause-Hugo, Jessie Allert, Brian R Curtis. Fatal

Transfusion Reaction Associated with Transfusion of IgM HNA-1a Antibodies in Plasma From a Male Donor. Transfusion 2009 AABB Meeting, New Orleans, LA.

44. Hopp KA, Weber KM, Bellissimo DB, Pietz, BC, Denomme G, Curtis BR, Johnson ST. Expanded

Use of Nanofluidic PCR Assay for Red Cell and Platelet Antigen Genotyping to Predict Phenotype. Transfusion 2009 AABB Meeting, New Orleans, LA.

45. Julie A. Peterson, Adam Kanack, Maria L. Gitter, Vipul Rathore, Janice McFarland, Brian R Curtis

,

and Richard H. Aster. Surface Plasmon Resonance (SPR) Analysis Detects Clinically Significant Low Avidity HPA-1a Antibodies Not Identified by Conventional Serology. Blood 2009 ASH Meeting, New Orleans, LA.

46. Curtis BR, Cox NJ, Sullivan MJ, Konkashbaev A, Bowens K, Hansen K, Aster RH. The neutrophil

alloantigen HNA-3a (5b) is encoded by an amino acid substitution in the choline transporter-like protein 2 (CTL2). Blood, 2009. Oral presentation, Late Breaking Abstracts Special Session, ASH Annual Meeting, New Orleans, LA.

47. Wu GG, Curtis BR, He BR, ZhouY., Zhou ZL, Yang YL, Li HY, Shen WD., Liu LJ., Zhao TM. Frequency of CD36 deficiency and identification of novel CD36 gene mutations in the Chinese population. Abstract presented to European Symposium on Platelet and Granulocyte Immunobiology, Beaune, France 2010.

48. Peterson J, Kanack A, Gitter M, Rathore V, McFarland J, Curtis BR, Aster R. Detection of low avidity HPA-1a antibodies in neonatal alloimmune thrombocytopenia (NAIT) using surface plasmon resonance. Abstract presented to European Symposium on Platelet and Granulocyte Immunobiology, Beaune, France 2010.

49. BR Curtis, SK Hui, TM Ellis, RH Aster. Class I HLA antibodies are the major cause of indeterminate

serotonin release assay (SRA) test results in heparin-induced thrombocytopenia (HIT). Abstract presented to European Symposium on Platelet and Granulocyte Immunobiology, Beaune, France 2010.

50. B.R. Curtis, R. Umeck, J.E. Harlan. (R2) ANTIBODIES: Moving closer to personalized therapeutics and diagnostics. Journal of Biomolecular Techniques 2011;Vol. 22: October supplement.

51. K Bowens, M Sullivan, BR Curtis. HNA-3 Genotype Frequencies in Six Racial Groups Using a High-Throughput 5’ Exonuclease Assay. Transfusion 2011 AABB Meeting, San Diego, CA.

52. MJ Sullivan, A Singla, S Kapadia, JR Bartholomew, RH Aster, BR Curtis. Severe Thrombocytopenia Caused by Protamine-Dependent Platelet Antibodies. Transfusion 2011 AABB Meeting, San Diego, CA. TOP POSTER AWARD


53. K Bowens, R Achterbergh, E Vermeer, L Porcelijn, W Deenik, K Daemen-Gubbels, RH Aster, BR

Curtis. Immune Thrombocytopenia Associated with Consumption of English Walnuts. Transfusion 2011 AABB Meeting, San Diego, CA.

54. Grace M. Thomas, Carla Carbo, Brian R. Curtis, Kimberly Martinod, Irina B. Mazo, Daphne Schatzberg, Stephen M. Cifuni, Tobias A. Fuchs, Ulrich H. von Andrian, MD, John H. Hartwig, Richard H. Aster, and Denisa D. Wagner. Extracellular DNA Traps Are Associated with Pathogenesis of TRALI in Humans and Mice. Blood 2011, ASH Meeting, San Diego, CA.

55. Julie A Peterson, Adam Kanack, Dhirendra Nayak, Daniel W Bougie, Janice G McFarland, Brian R

Curtis and Richard Aster. Prevalence and clinical significance of low avidity HPA-1a antibodies in women exposed to HPA-1a during pregnancy. Blood 2012, ASH Meeting, Atlanta, GA.

56. Brian R. Curtis, Wayne Bottner, Scott Grady, Janice G. McFarland, Jerome Gottschall. TRALI caused

by transfusion of red blood cells containing HNA-1b and HLA leukocyte antibodies. Transfusion 2013 AABB Meeting, Denver, CO.

57. J. Esensten, M. Moayeri, A. Nambiar, BR Curtis, RH Aster, M. Geere, S. Pandey. A complex case of severe thrombocytopenia and platelet refractoriness consistent with post-transfusion purpura. 2013 SouthCentral Association of Blood Banks Meeting, CA.

58. Mia Sullivan, Scott Grady, Janice G McFarland, Brian R Curtis. A Multiplex Flow Cytometry Bead

Assay For Simultaneous Detection Of IgG, IgA, IgM Heparin-Dependent Antibodies. Blood 2013, ASH Meeting, New Orleans, LA.

59. Janice G McFarland, James B Bussel, Richard A Aster, Brian R Curtis. Diagnostic yield of serologic

evaluation for neonatal alloimmune thrombocytopenia (NAIT) in cases with fetal abnormalities without documented thrombocytopenia. Blood 2013, ASH Meeting, New Orleans, LA.

60. Daniel Bougie, Julie Peterson, Adam Kanack, Brian Curtis and Richard Aster. Antibodies specific for human neutrophil antigen 3a (HNA-3a) recognize complex epitopes on choline transporter protein 2 (CTL2): Implications for HNA-3a antibody detection. Blood 2013, ASH Meeting, New Orleans, LA.

61. Julie Peterson, Maria Gitter, Daniel Bougie, Shannon Pechauer, Kathleen Hopp, Bradley Pietz, Aniko Szabo, Brian Curtis, Janice McFarland and Richard Aster. Role of maternal immunization against low frequency human platelet antigens (HPA) in neonatal alloimmune thrombocytopenia (NAIT). Blood 2013, ASH Meeting, New Orleans, LA.

62. Mia J. Sullivan, Scott Grady, Jancie G. McFarland, Brian R Curtis. Rapid detection of IgG, IgA, IgM antibodies associated with heparin-induced thrombocytopenia (HIT). ISTH Meeting, Milwaukee, WI 2014.

63. LeeAnn Weitekamp, Mia Sullivan, Cindy Raven, Judy Larison, Brian R Curtis. First example of a

neutrophil alloantibody specific for Human Neutrophil Antigen (HNA)-4b. Abstract accepted to European Symposium on Platelet and Granulocyte Immunobiology, Bad Homburg, Germany 2014.


64. Anand Padmanabhan, Curtis Jones, Brian R Curtis, Daniel W. Bougie, Mia Sullivan, Namrata Peswan, Janice McFarland, Daniel Eastwood, Demin Wang, and Richard H. Aster. A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT). Blood 2015, ASH Meeting, Orlando, FL.

65. Huiying Zhi, Nanyan Zhang, Jamie Foeckler, Shawn Kalloway, Sridhar Rao, Brian Curtis, Hardy Weiler, and Peter J. Newman. Crispr/Cas9-Mediated Generation of Mouse Platelets Expressing the Human Platelet Alloantigen, HPA-1a. Blood 2015, ASH Meeting, Orlando, FL.

66. Huiying Zhi, Panida Lertkiatmongkol, Brian Curtis, and Peter J. Newman. Involvement of the EGF

Domain in the Formation of the Human Platelet Alloantigen, HPA-1a. Blood 2015, ASH Meeting, Orlando, FL.

67. Brian R. Curtis, Krista Bowens, Gavin Falk, Richard Aster. Is post-transfusion purpura (PTP) an

autoimmune disorder? European Symposium on Platelet and Granulocyte Immunobiology, Stockholm, Sweden 2016.

68. Anand Padmanabhan, Curtis G Jones, Shannon M Pechauer, Brian R Curtis, Daniel W. Bougie, Mia J Sullivan, Mehraboon S. Irani, Binod Dhakal, Lisa M. Baumann Kreuziger, Brenda M. Pierce, and Richard H. Aster. A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT. ). Blood 2016, ASH Meeting, San Diego, CA.

69. Anand Padmanabhan, Curtis G Jones, Shannon M Pechauer, Barabara J. Bryant, Jack B. Alperin, Mehraboon S. Irani, Binod Dhakal, Brian R Curtis, Daniel W. Bougie, Mia J Sullivan, , Renren Wen, Demin Wang, and Richard H. Aster. Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation. Blood 2016, ASH Meeting, San Diego, CA.

70. PK Narayanan, L Shen, BR Curtis, M Bourdon, JP Nolan, C Ho_master, S Burel, SP Henry. Liver and Splenic Clearance of Platelets Following Treatment of Cynomolgus Monkeys with ISIS 104838 is Accompanied by Innate Immune Activation. Society of Toxicology 56th Annual Meeting and ToxExpo Baltimore, MD, 2017.

71. C. Harmon, H. Worrell, L. Cooling, J. Frederiksen, L. Shao C. Harmon, H. Worrell, L. Cooling, J.

Frederiksen, L. Shao, MJ Sullivan, BR Curtis. Platelet Transfusion Refractoriness due to CD36 Deficiency in the Setting of Myelodysplastic Syndrome. AABB Meeting, San Diego, CA, 2017.

72. Sameer Khatri, Charles Harmon, Brian Curtis, Chisa Yamada. When CD36 Negative Platelet Unit Is Not Available for a Patient with Anti-CD36 Antibodies. AABB Meeting, San Diego, CA, 2017.

73. Aye Myat Myat Thinn, Zhengli Wang, Dongwen Zhou, Yan Zhao, Brian R. Curtis, Jieqing Zhu. Structural and Functional Characterization of a Single Chain β3 Integrin in Solution and on the Cell Surface and the Implications on Integrin Activation and Pathogenesis of Anti-HPA-1a Alloantibodies. Blood 2017, ASH Meeting, Atlanta, GA.

https://ash.confex.com/ash/2015/webprogram/Paper81378.html










74. BR Curtis, YS Hsu, N Podoltsev, J Lacy, S Curtis, RA DeSimone, MS Samuel, K Zutavern, DW Bougie, RH Aster. Drug-Induced Immune Thrombocytopenia (DITP) Caused by Multiple Drug-Dependent Platelet-Reactive Antibodies (DDAbs) in Patients Undergoing Oxaliplatin-Containing Combination Chemotherapy for Metastatic Colon Cancer. Blood 2017, ASH Meeting, Atlanta, GA.

curriculum vitae name: brian r. curtis, ph.d., d(abmli), mt(ascp… curtis cv 2018.pdf · brian...

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