curriculum vitae - 近畿大学病院 · web viewb. research awards . national multiple sclerosis...

CURRICULUM VITAE

I. PERSONAL DATA

A. Name: Ikuo TsunodaB. Birthplace: Fukushima, Japan C. Citizenship: Japanese D. Address: Department of Microbiology

Kindai University Faculty of Medicine 377-2 Ohnohigashi, Osakasayama,

Osaka 589-8511, JapanE. Telephone: 81-72-366-0221F. E-mail: [email protected], [email protected]. Home page: http://www.med.kindai.ac.jp/microbio/

II. EDUCATION

1990 M.D. Tohoku University School of Medicine, Sendai, Japan, General Medicine1994 Ph.D. Tohoku University School of Medicine, Sendai, Japan, Neuropathology

1995-1999 Postdoctoral Fellow, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah

III. PROFESSIONAL EXPERIENCE

A. Full-time Positions

1994 Research Associate, Department of Neurological Sciences, Tohoku University School of Medicine, Sendai, Japan

1999-2002 Research Associate, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah

2002-2005 Instructor, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah

2005-2007 Assistant Professor, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah

2007-2009 Assistant Professor, Department of Pathology, Division of Cell Biology & Immunology, University of Utah School of Medicine, Salt Lake City, Utah

2008-2009 Adjunct Assistant Professor, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah

2009-2015 Assistant Professor, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana

http://www.med.kindai.ac.jp/microbio/

mailto:[email protected]

mailto:[email protected]

Ikuo Tsunoda, M.D., Ph.D. 2

2015-2016 Associate Professor, Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana

2015-2016 Adjunct Associate Professor, Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana

2016-present Professor and Chair, Department of Microbiology, Kindai University Faculty of Medicine, Osaka, Japan

B. Research Awards

National Multiple Sclerosis Society (NMSS) Pilot Research Award PP0994, 2004-2005, Lesion development from inside (axon) to outside (myelin): Inside-Out models. $44,000. (Tsunoda I is PI).

The Funding Incentive Seed Grant, University of Utah, 2006-2008, Does Axonal Injury Recruit Inflammatory Cells to the Site of Axonal Degeneration, Targeting Demyelinating Lesions? Inside-Out Model for Multiple Sclerosis. $24,000. (Tsunoda I is PI).

National Multiple Sclerosis Society (NMSS) Pilot Research Award PP1499, 2008-2009, Treatment of Animal Models for MS with Resveratrol, a Natural Compound in Red Wine. $44,000. (Tsunoda I is PI).

National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS), R21NS059724, 2008-2011Axonal Degeneration can Trigger Demyelinating Disease. $341,840. (Tsunoda I is PI).

Louisiana State University Health Sciences Center (LSUHSC), Research Council Seed package, 07/01/09 – 06/30/12 $150,000. (Tsunoda I is PI).

National Institutes of Health (NIH)/National Center for Research Resources (NCRR) (5P20RR018724-10)/National Institute of General Medical Sciences (NIGMS) (8P20 GM103433-10), 2010-2014Centers of Biomedical Research Excellence (COBRE): Th Cells in Theiler’s Virus Persistence and Pathology. $370,000. (Tsunoda I is Project Leader).

Malcolm Feist Cardiovascular Research Fellowship, 2011-2015Systems Biology Approach for Molecular Mechanisms in Viral Myocarditis. $225,000. (Funds support salary and supplies for Dr. Seiichi Omura in Tsunoda laboratory, Tsunoda I, Sponsor/mentor)

Malcolm Feist Cardiovascular Research Fellowship, 2011-2015


Regulatory Role of Natural Killer T cells in Cardiovirus-induced Myocarditis. $225,000. (Funds support salary and supplies for Dr. Fumitaka Sato in Tsunoda laboratory, Tsunoda I, Sponsor/mentor)

TEVA Neuroscience Investigator-Initiated Studies Program, 2012-2015Neuroprotective Role of Glatiramer Acetate in a Viral Model for Multiple Sclerosis. $125,000. (Tsunoda I is PI).

Louisiana State University Health Sciences Center (LSUHSC), Research Development funds, 2013-2014. $100,000. (Tsunoda I is PI).

National Institutes of Health (NIH)/National Institute of General Medical Sciences (NIGMS) Centers of Biomedical Research Excellence (COBRE) III Pilot Grant (P30-GM110703), 2014-2016Role of Th17/Treg Immunoregulatory Axis in a Viral Model for Multiple Sclerosis. $100,000. (Tsunoda I is PI).

Louisiana State University Health Sciences Center (LSUHSC), Neurology Research Grant, 2015-2017. $75,000. (Tsunoda I is PI).

Japan Society for the Promotion of Science (Grants-in-Aid for Scientific Research-KAKENHI, 16H07356) 2016-2017. Roles of Th17/Treg Differ in a Viral Model for Multiple Sclerosis Depending on Disease Phases? 2,430,000 yen. (Tsunoda I is PI).

C. Editorial Committees and Reviewer Experience

Grant Reviewers2005-2009 Ad Hoc Merit Grant Reviewer, The Salt Lake VA Research and

Development Committee2008 Ad Hoc Reviewer, The National Multiple Sclerosis Society

(NMSS, Pilot Research Award)2010 Study Section Reviewer, The Congressionally Directed Medical

Research Programs (CDMRP), Department of Defense, Multiple Sclerosis Research Program (MRSP)

2010-2013 Reviewer, The Italian Multiple Sclerosis Society (AISM-FISM)2010 Reviewer, The Italian Ministry of Health (Research Funding Call

Grant 2009)2013 Study Section Reviewer, The Department of Veterans Affairs Neurobiology-B (NURB) Scientific Review Group

2014-present Reviewer, Multiple Sclerosis Society, UK (Project Grant)2015-present Reviewer, Swiss Multiple Sclerosis Society (Research Grant)2015-present Reviewer, National Institutes of Health (NIH), Centers of Biomedical

Research Excellence (COBRE), Pacific Center for Emerging Infectious


Diseases Research, COBRE Small Grants Program P30GM114737. University of Hawaii

2016 Reviewer, Florida Department of Health, Zika Research Grant Initiative 2019 Reviewer, Research Foundation - Flanders (Fonds voor

Wetenschappelijk Onderzoek - Vlaanderen – FWO), Senior Project Fundamental Research Project, Belgium.

Editorial Members2009-present Editorial Board Member, Multiple Sclerosis International2010-2012 Editorial Board Member, Neural Regeneration Research2011-2015 Editorial Board Member, World Journal of Virology2012-2015 Editorial Board Member, Virology Discovery2014-present Editorial Board Member, BMC Neurology2014 Co-Chairs Scientific Committee, Congress of Immunology and

Molecular Immunopathology (CIMIP)2016-present Councilor, Japanese Society for Neuroimmunology2016-present Medical Advisor, Japanese Multiple Sclerosis Society2016-present Editorial Board Member, Clinical & Experimental Neuroimmunology

(CENI)2018-present Editorial Board Member, Frontiers in Neurology

Ad Hoc Reviewers Acta Neurobiologiae Experimentalis, Acta Neuropathologica, Acta Neuropathologica Communications, Advances in Virology, Advances in Virus Research, American Journal of Physiology – Heart and Circulatory Physiology, Antiviral Research, Autoimmunity, Biomedicine & Pharmacotherapy, Bioscience Reports, BioTechniques, BMC Neurology, BMC Neuroscience, Brain, Behavior, and Immunity, Brain Research, Brain Sciences, Clinical and Experimental NeuroimmunologyClinical Investigation, European Journal of Pharmacology Expert Review of Neurotherapeutics, Hepatic Medicine: Evidence and ResearchFrontiers in Neurology, Helicobacter, Human Immunology, Immunological Investigations, International Journal of Molecular Sciences, Journal of Cellular and Molecular Medicine, Journal of Neuroimmune Pharmacology, Journal of Neuroimmunology, Journal of Neuroinflammation, Journal of Neuropathology & Experimental Neurology, Journal of NeuroVirology, Journal of Virology, Journal of Visualized Experiments (JoVE), Medical Hypothesis, Nanomedicine: Nanotechnology, Biology and MedicineNeuroscience, Neuroscience and Behavioral Reviews, Neuroscience Journal, Neuroscience Research, NeurotherapeuticsOxidative Medicine and Cellular Longevity, PathophysiologyPLoS One, PLoS Pathogen, Proceedings of the National Academy of Sciences of the United States of America, Progress in Neurobiology, Scientific Reports, Vaccine, Viral ImmunologyVirology, Virology Journal, World Journal of Neurology


IV. AWARDS AND MEMBERSHIPS IN PROFESSIONAL SOCIETIES

1996 The Educational Commission for Foreign Medical Graduates (ECFMG) Certification (certification number 0-449-653-5)

2006 The Consortium of Multiple Sclerosis Centers (CMSC) Travel Award

2008 American Association of Immunologists (AAI) Junior Faculty Travel Grant Award

2015 The LSUHSC-Shreveport Chancellor’s Award: Nicholas E. Martinez, PhD (Tsunoda laboratory Graduate Student from 2009-2014). The Award is presented to the most outstanding Graduate Student of Louisiana State University Health Sciences Center-Shreveport among graduates.

1990-2011 Member, Japanese Society of Neurology1992-2012 Member, Society of Japanese Virologists2002-2011 Member, International Society for NeuroVirology (ISNV)2003-present Member, The American Association of Immunologists (AAI)2003-present Member, The American Society for Virology (ASV)2003-present Member, The American Society for Microbiology (ASM)2012-2013 Member, International Society of Neuroimmunology (ISNI)2012-2013 Member, American Academy of Neurology (AAN)2012-2016 Member, American Heart Association (AHA)2013-present Member, American College of Cardiology (ACC)2016-present Councilor, Japanese Society for Neuroimmunology2016-present Member, Japanese Society for Neuroinfectious Diseases

BIBLIOGRAPHY

I. ORIGINAL PUBLICATIONS

1. Iwasaki Y, Sako K, Tsunoda I and Ohara Y. (1993). Phenotypes of mononuclear cell infiltrates in human CNS. Acta Neuropathol. (Berl) 85 (6): 653-657.

2. Tsunoda I, Awano H, Kayama H, Tsukamoto T, Ueno S, Fujiwara T, Watanabe M and Yamamoto T. (1994). Idiopathic AA amyloidosis manifested by autonomic neuropathy, vestibulocochleopathy, and lattice corneal dystrophy. J. Neurol. Neurosurg. Psychiatry 57 (5): 635-637.

3. Saito T, Hida C, Tsunoda I, Tsukamoto T and Yamamoto T. (1994). Melkerson-Rosenthal syndrome: distal facial nerve branch palsies, masseter myopathy and corticosteroid treatment. Fukushima J. Med. Sci. 40 (1): 39-44.


4. Tsunoda I, Kanno H, Watanabe M, Shimoji S, Hirayama K, Sumita H and Yamamoto T. (1994). Acute simultaneous bilateral vestibulocochlear impairment in neuro-Behcet's disease: A case report. Auris Nasus Larynx 21 (4): 243-247.

5. Tsunoda I, Endo K, Hirayama K, Saito N, Hida C, Tsukamoto T and Yamamoto T. (1995). The POEMS syndrome with intracranial hypertension. Fukushima J. Med. Sci. 41 (1): 61-69.

6. Tsunoda I, Iwasaki Y, Sako K, Terunuma H and Ohara Y. (1996). A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses (TMEV). Acta Neuropathol. (Berl) 91 (6): 595-602.

7. Tsunoda I and Fujinami RS. (1996). Two models for multiple sclerosis: Experimental allergic encephalomyelitis and Theiler’s murine encephalomyelitis virus. J. Neuropathol. Exp. Neurol. 55 (6): 673-686.

8. Tsunoda I, Kurtz CIB and Fujinami RS. (1997). Apoptosis in acute and chronic central nervous system disease induced by Theiler’s murine encephalomyelitis virus. Virology 228 (2): 388-393.

9. Tsunoda I, McCright IJ, Kuang L-Q, Zurbriggen A and Fujinami RS. (1997). Hydrocephalus in mice infected with Theiler’s murine encephalomyelitis virus variant. J. Neuropath. Exp. Neurol. 56 (12): 1302-1313.

10. Rose J, Hill K, Wada Y, Kurtz C, Tsunoda I, Fujinami RS and Cross A. (1998). Nitric oxide synthase inhibitor, aminoguanidine, alters inflammation and demyelination produced by Theiler’s virus infection. J. Neuroimmunol. 81 (1-2): 82-89.

11. Tsunoda I, Kuang L-Q, Tolley ND, Whitton JL and Fujinami RS. (1998). Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA. J. Neuropath. Exp. Neurol. 57 (8): 758-767.

12. Wada Y, McCright IJ, Whitby FG, Tsunoda I and Fujinami RS. (1998). Replacement of loop II of VP1 of the DA strain with loop II of the GDVII strain of Theiler’s murine encephalomyelitis virus alters neurovirulence, viral persistence and demyelination. J. Virol. 72 (9): 7557-7562.

13. Tolley ND, Tsunoda I and Fujinami RS. (1999). DNA vaccination of SJL/J mice against Theiler’s murine encephalomyelitis virus leads to alternations in CNS disease. J. Virol. 73 (2): 993-1000.

14. Tsunoda I, Sette A, Fujinami RS, Oseroff C, Ruppert J, Dahlberg C, Southwood, S, Arrhenius T, Kuang L-Q, Kubo RT, Chesnut RW and Ishioka G. (1999). Lipopeptide particles as the immunologically active component of CTL inducing vaccines. Vaccine 17 (7-8): 675-685.

15. McCright IJ, Tsunoda I, Whitby FG and Fujinami RS. (1999). Theiler’s viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis. J. Virol. 73 (4): 2814-2824.


16. Tsunoda I, Tolley ND, Theil DJ, Whitton JL, Kobayashi H and Fujinami RS. (1999). Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA. Brain Pathol. 9 (3): 481-493.

17. Theil DJ, Tsunoda I, Libbey JE, Derfuss TJ and Fujinami RS. (2000). Alterations in cytokine but not chemokine mRNA expression during three distinct Theiler’s virus infections. J. Neuroimmunol. 104 (1): 22-30.

18. Tsunoda I, Kuang, L-Q, Theil DJ and Fujinami RS. (2000). Antibody association with a novel model for primary progressive multiple sclerosis: Induction of relapsing-remitting and progressive forms of EAE in H2S mouse strains. Brain Pathol. 10 (3): 402-418.

19. Libbey JE, McCright IJ, Tsunoda I, Wada Y and Fujinami RS. (2001). Peripheral nerve protein, P0, as a potential receptor for Theiler’s murine encephalomyelitis virus. J. NeuroVirol. 7 (2): 97-104.

20. Tsunoda I, Wada Y, Libbey JE, Cannon TS, Whitby FG and Fujinami RS. (2001). Prolonged gray matter disease without demyelination caused by Theiler’s murine encephalomyelitis virus with a mutation in VP2 puff B. J. Virol. 75 (16): 7494-7505.

21. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2001). Viruses can silently prime for and trigger central nervous system autoimmune disease. J. NeuroVirol. 7 (3): 220-227.

22. Libbey JE, Tsunoda I and Fujinami RS. (2002). Altered cell growth and morphology in a BHK-21 cell mutant that lacks a receptor for Theiler’s murine encephalomyelitis virus (TMEV). Virology 294 (1): 85-93.

23. McCright IJ, Tsunoda I and Fujinami RS. (2002). Mutation in loop I of VP1 of Theiler’s virus delays viral RNA release into cells and enhances antibody-mediated neutralization: A mechanism for the failure of persistence by the mutant virus. J. NeuroVirol. 8 (2): 100-110.

24. Tsunoda I and Fujinami RS. (2002). Inside-Out versus Outside-In models for virus induced demyelination: Axonal damage triggering demyelination. Springer Semin. Immunopathol. 24 (2): 105-125.

25. Tsunoda I, Kuang L-Q and Fujinami RS. (2002). Induction of autoreactive CD8+

cytotoxic T cells during Theiler’s murine encephalomyelitis virus infection: Implications for autoimmunity. J. Virol. 76 (24): 12834-12844.

26. Wang M, Libbey JE, Tsunoda I and Fujinami RS. (2003). Modulation of immune system function by measles virus infection. II. Infection of B cells leads to the production of a soluble factor that arrests uninfected B cells in G0/G1. Viral. Immunol. 16 (1): 45-56.

27. Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2003). Axonal injury heralds virus induced demyelination. Am. J. Pathol. 162 (4): 1259-1269. PMCID: PMC1851221


28. Tsunoda I, Lane TE, Blackett J and Fujinami RS. (2004). Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult. Scler. 10 (1): 26-34.

29. Tsunoda I, Kuang L-Q, Igenge IZM and Fujinami RS. (2005). Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation. J. Neuroimmunol. 160 (1-2): 122-134.

30. Tsunoda I, Kuang L-Q, Kobayashi-Warren M and Fujinami RS. (2005). Central nervous system pathology caused by autoreactive CD8+ T cell clones following virus infection. J. Virol. 79 (23): 14640-14646. PMCID: PMC1287580

31. Tsunoda I, Libbey JE, Kuang L-Q, Terry EJ and Fujinami RS. (2005). Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am. J. Pathol. 167 (6): 1631-1646.

32. Tsunoda I, Libbey JE, Kobayashi-Warren M and Fujinami RS. (2006). IFN-γ production and astrocyte recognition by autoreactive T cells induced by Theiler’s virus infection: role of viral strains and capsid proteins. J. Neuroimmunol. 172 (1-2): 85-93.

33. McCoy L, Tsunoda I and Fujinami RS. (2006). Multiple sclerosis and virus induced immune responses: Autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity 39 (1): 9-19.

34. Libbey JE, Peterson LK, Tsunoda I and Fujinami RS. (2006). Monoclonal MOG-reactive autoantibody from progressive EAE has the characteristics of a natural antibody. J. Neuroimmunol. 173 (1-2): 135-145.

35. Carlson NG, Hill KE, Tsunoda I, Fujinami RS and Rose JW. (2006). The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: Implications for multiple sclerosis. J. Neuroimmunol. 174 (1-2): 21-31.

36. Libbey JE, Tsunoda I and Fujinami RS. (2006). Autologous hematopoietic stem cell transplantation: A cure for multiple sclerosis? Future Neurol. 1 (4): 403-408.

37. Tsunoda I, Tanaka T, Terry EJ and Fujinami RS. (2007). Contrasting roles for axonal degeneration in an autoimmune versus viral model of multiple sclerosis: When can axonal injury be beneficial? Am. J. Pathol. 170 (1): 214-226. PMCID: PMC1762678

38. Libbey JE, Tsunoda I, Whitton JL and Fujinami RS. (2007). Infectious RNA isolated from the spinal cords of mice chronically infected with Theiler’s murine encephalomyelitis virus. J. Virol. 81 (6): 3009-3011.

39. Tsunoda I, Terry EJ, Marble BJ, Lazarides E, Woods C and Fujinami RS. (2007). Modulation of experimental autoimmune encephalomyelitis by VLA-2 blockade. Brain Pathol. 17 (1): 45-55.


40. Peterson LK, Tsunoda I, Masaki T and Fujinami RS. (2007). Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis. J. Neuroimmunol. 183 (1-2): 69-80.

41. Tsunoda I, Libbey JE and Fujinami RS. (2007). Sequential polymicrobial infections lead to CNS inflammatory disease: Possible involvement of bystander activation in heterologous immunity. J. Neuroimmunol. 188: 22-33. PMCID: PMC1987327

42. Tsunoda I, Tanaka T, Saijoh Y and Fujinami RS. (2007). Targeting inflammatory demyelinating lesions to sites of Wallerian degeneration. Am. J. Pathol. 171 (5): 1563-1575. PMCID: PMC2043517

43. Tsunoda I, Libbey JE and Fujinami RS. (2007). TGF-β suppresses T cell infiltration and VP2 puff B mutation enhances apoptosis in acute polioencephalitis induced by Theiler’s virus. J. Neuroimmunol. 190 (1-2): 80-89. PMCID: PMC2128758

44. Peterson LK, Tsunoda I and Fujinami RS. (2008). Role of CD5+ B-1 cells in EAE pathogenesis. Autoimmunity 41 (5): 353-362.

45. Peterson LK, Tsunoda I, Libbey JE and Fujinami RS. (2008). Role of B:T cell ratio in suppression of clinical signs: a model for silent MS. Exp. Mol. Pathol. 85 (1): 28-39. PMCID: PMC2614211

46. Tsunoda I. (2008). Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. Future Virol. 3 (6): 579-593. PMCID: PMC2600527

47. Peterson LK, Masaki T, Wheelwright SR, Tsunoda I and Fujinami RS. (2008). Cross-reactive myelin antibody induces renal pathology. Autoimmunity 41 (7): 526-36. PMCID: PMC3039869

48. Theil DJ, Libbey LE, Rodriguez F, Whitton JL, Tsunoda I, Derfuss TJ and Fujinami RS. (2008). Targeting myelin proteolipid protein to the MHC class I pathway by ubiqitination modulates the course of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 204 (1-2): 92-100. PMCID: PMC2646907

49. Tsunoda I, Tanaka T and Fujinami RS. (2008). Regulatory role of CD1d in neurotropic virus infection. J. Virol. 82 (20): 10279-10289. PMCID: PMC2566251

50. Tsunoda I, Libbey JE and Fujinami RS. (2009). Theiler's murine encephalomyelitis virus attachment to the gastrointestinal tract is associated with sialic acid binding. J. NeuroVirol. 15 (1): 81-89. PMCID: PMC2882804

51. Tsunoda I, Tanaka T, Taniguchi M and Fujinami RS. (2009). Contrasting roles for V14+ NKT cells in a viral model for multiple sclerosis. J. NeuroVirol. 15 (1): 90-98. PMCID: PMC2671644

52. Penberthy WT and Tsunoda I. (2009). The importance of NAD in multiple sclerosis. Curr. Pharm. Des. 15 (1): 64-99. PMCID: PMC2651433


53. Tsunoda I and Fujinami RS. (2010). Neuropathogenesis of Theiler’s murine encephalomyelitis virus infection, a viral model for multiple sclerosis. J. Neuroimmune Pharml. 5 (3): 355-369. PMCID: PMC2888670

54. Libbey JE, Tsunoda I and Fujinami RS. (2010). Studies in the modulation of experimental autoimmune encephalomyelitis. J. Neuroimmune Pharm. 5 (2): 168-175. PMCID: PMC3046865

55. Greenlee JE, Clawson SA, Hill KE, Wood BL, Tsunoda I and Carlson NG. (2010). Purkinje cell death after uptake of anti-Yo antibodies in cerebellar slice cultures. J. Neuropathol. Exp. Neurol. 69 (10): 997-1007. PMCID: PMC2959164

56. Sato F, Tanaka H, Hasanovic F and Tsunoda I. (2011). Theiler’s virus infection: Pathophysiology of demyelination and neurodegeneration. Pathophysiology 18 (1): 31-41. PMCID: PMC2937201

57. Sato F, Martinez NE, Omura S and Tsunoda I. (2011). Heterogeneity versus homogeneity of multiple sclerosis. Expert Rev. Clin. Immunol. 7 (2): 165-167. PMCID: PMC3085181

58. Libbey JE, Cusick MF, Tsunoda I and Fujinami RS. (2012). Antiviral CD8+ T cells cause an experimental autoimmune encephalomyelitis-like disease in naive mice. J. NeuroVirol. 18 (1): 45-54. PMCID: PMC3327473

59. Tsunoda I, Libbey JE and Fujinami RS. (2012). Immunization with structural and non-structural proteins of Theiler's murine encephalomyelitis virus alters demyelinating Disease. J. NeuroVirol. 18 (2): 127-137. PMCID: PMC3335973

60. Martinez NE, Sato F, Kawai E, Omura S, Chervenak RP and Tsunoda I. (2012). Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis. Future Virol. 7 (6): 593-608. PMCID: PMC3457923

61. Libbey JE, Tsunoda I and Fujinami RS. (2012). Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis. J. NeuroVirol. 18 (6): 471-478. PMCID: PMC3508306

62. Karlsson F, Martinez NE, Gray L, Zhang S, Tsunoda I, and Grisham MB. (2013). Therapeutic evaluation of ex vivo-generated vs. natural regulatory T-cells in a mouse model of chronic gut inflammation. Inflamm Bowel Dis. 19 (11): 2282-2294. PMCID: PMC3812251

63. Martinez NE, Sato F, Omura S, Minagar A, Alexander JS and Tsunoda I. (2013). Immunopathological patterns from EAE and Theiler’s virus infection: Is multiple sclerosis a homogenous 1-stage or heterogeneous 2-stage disease? Pathophysiology 20 (1): 71-84. PMCID: PMC3430756

64. Sato F, Martinez NE, Shahid M, Rose JW, Carlson NG and Tsunoda I. (2013). Resveratrol exacerbates both autoimmune and viral models for multiple sclerosis. Am. J. Pathol. 183 (5): 1390-1396. PMCID: PMC3814682


65. Chaitanya GV, Omura S, Sato S, Martinez NE, Minagar A, Ramanadhan M, Guttman BW, Zivadinov R, Tsunoda I and Alexander JS. (2013). Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature. J. Neuroinflammation 10 (1): 125. PMCID: PMC3854084

66. Alexander JS, Prouty L, Tsunoda I, Ganta CV and Minagar A. (2013). Venous endothelial injury in central nervous system diseases. BMC Med. 11: 219. PMCID: PMC3851779

67. Fernando V, Omura S, Martinez NE, Sato F, Kawai E, Elliott SF, Takahashi S, Yoh K, and Tsunoda I. (2014). Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice. Int. J. Mol. Sci. 15: 1700-1718. PMID: 24463292

68. Martinez NE, Karlsson F, Sato F, Kawai E, Omura S, Grisham MB, Minagar A and Tsunoda I. (2014). Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis. Brain Pathol. 24 (5): 436-51. PMID: 24417588

69. Omura S, Kawai E, Sato F, Martinez NE, Chaitanya GV, Rollyson P, Cvek U, Trutschl M, Alexander JS, and Tsunoda I. (2014). Bioinformatics multivariate analysis determined a set of phase-specific biomarker candidates in a novel mouse model for viral myocarditis. Circ. Cardiovasc. Genet. 7: 444-454. PMID: 25031303

70. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Jaskowski TD, and Carlson NG. (2014). Neuronal uptake of anti-Hu antibody but not anti-Ri antibody leads to cell death in brain slice cultures. J. Neuroinflammation, 11 (1): 160. PMID: 25228406

71. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2014). RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis in novel Th17-biased transgenic mice. J. Neuroimmunol. 276: 142-149. PMID: 25288300

72. Sato F, Omura S, Kawai E, Martinez NE, Acharya MM, Reddy PC, Chaitanya GV, Alexander JS and Tsunoda I. (2014). Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler’s virus infection. Cell. Immunol. 292 (1-2): 85-93.

73. Kawai E, Sato F, Omura S, Martinez NE, Reddy PC, Taniguchi M., and Tsunoda I. (2015). Organ-specific protective role of NKT Cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain. J. Neuroimmunol. 278 (1-2):174-184. PMID: 25434008

74. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2015). Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav. Immun. 43: 86-97. PMID:25046854

75. Becker F, Potepalov S, Shehzahdi R, Bernas M, Witte M, Abreo F, Traylor J, Orr WA, Tsunoda I, and Alexander JS. (2015). Downregulation of FoxC2 increased susceptibility to experimental colitis: Influence of lymphatic drainage function? Inflamm. Bowel Dis. 21 (6): 1282-96. PMID:25822012


76. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, and Carlson NG. (2015). Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One 10 (4):e0123446. PMID: 25885452

77. Al-Kofahi M, Becker F, Gavins FNE, Woolard M, Tsunoda I, Wang Y, Ostanin D, Zawieja DC, Muthuchamy M, von der Weid PY, and Alexander JS. (2015). IL-1β reduces tonic contraction of mesenteric lymphatic muscle cells, with involvement of cyclooxygenase-2 and prostaglandin E2. Br. J. Pharmacol. 172 (16): 4038-51. PMID: 25989136

78. Alexander JS, Chervenak R, Weinstock-Guttman B, Tsunoda I, Ramanthan M, Martinez N, Sato F, Chaitanya GV, Minagar A, Monceaux C, McGee J, Jennings MH, Becker F, Cvek U, Trutschl M, and Zivadinov R. (2015). Blood circulating microparticle species in relapsing-remitting and secondary progressive multiple sclerosis. A case-control, cross sectional study with conventional MRI and advanced iron content imaging outcomes. J. Neurol. Sci. 355 (1-2): 84-9. PMID: 26073484

79. Sato F, Martinez NE, Stewart EC, Omura S, Alexander JS, and Tsunoda I. (2015). “Microglial nodule” and “newly forming lesion” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model. BMC Neurol., 15:219

80. Becker F, Kurmaeva, E, Gavins FNE, Stevenson EV, Navratil AR, Jin L, Tsunoda I, Orr AW, Alexander JS, Ostanin DV. (2016). A critical role for monocytes/macrophages during intestinal inflammation-associated lymphangiogenesis. Inflamm. Bowel Dis. 22：1326-1345. PMID: 26950310

81. Yun J.W. Xiao A, Tsunoda I, Minagar A, Alexander JS. (2016). From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases. Pathophysiology 23 (4): 265-274. PMID: 27531185.

82. Tsunoda I, Sato F, Omura S, Fujita M, Sakiyama N, Park A-M. (2016). Three immune-mediated disease models induced by Theiler’s virus: Multiple sclerosis, seizures, and myocarditis. Clin Exp Neuroimmunol, 7 (4): 330-345.

83. Tsunoda I, Omura S, Sato F, Kusunoki S, Fujita M, Park A-M, Hasanovic F, Yanagihara R, and Nagata S. (2016). Neuropathogenesis of Zika virus infection: Potential roles of antibody-mediated pathology. Acta Med Kindai Univ, 41 (2): 37-52.

84. Kanai K, Park A-M, Yoshida H, Tsunoda I, and Yoshie O. (2017). IL-35 suppresses lipopolysaccharide-induced airway eosinophilia in EBI3-defieicent mice. J Immunol 198 (1), 119-121.

85. Tsunoda I. (2017). Lymphatic system and gut microbiota affect immunopathology of neuroinflammatory diseases, including multiple sclerosis, neuromyelitis optica, and Alzheimer’s disease. Clin Exp Neuroimmunol, 8(3): 177-179.


86. Park A-M, Omura S, Fujita M, Sato F, and Tsunoda I. (2017). Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer’s disease: 10 pitfalls of microbiome studies. Clin Exp Neuroimmunol, 8(3): 215-232.

87. Fujita M, Omura S, Sato F, Park AM, and Tsunoda I. (2017). Influx and efflux of immune cells in the central nervous system. Anat Physiol 7 (4): 274.

88. Sato F, Kawai E, Martinez NE, Omura S, Park A-M, Takahashi S, Yoh K, and Tsunoda I. (2017). T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection. Sci. Rep. 7 (1): 10496. PMID: 28874814

89. Smith HK, Omura S, Vital SA, Becker F, Tsunoda I, Peirce-Cottler S, and Gavins FNE. (2018). Metallothionein-I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke. FASEB J, 32 (5): 2381-2394.

90. Matsuo K, Nagakubo D, Yamamoto S, Shigeta A, Tomida S, Fujita M, Hirata T, Tsunoda I, Nakayama T, Yoshie O. (2018). CCL28-deficient mice have reduced IgA antibody-secreting cells and an altered microbiota in the colon. J Immunol., 200 (2): 800-809.

91. Omura S, Sato F, Martinez NE, Range T, Ekshyyan L, Minagar A, Alexander JS, and Tsunoda I. (2018). Immunoregulation of Theiler’s virus-induced demyelinating disease by glatiramer acetate without suppression of anti-viral immune response. Arch Virol, 163: 1279-1284.

92. Kanai K, Park AM, Watanabe A, Arikawa T, Yasui T, Yoshida H, Tsunoda I, Yoshie O. (2018). Murine γ-herpesvirus 68 induces severe lung inflammation in IL-27-deficient mice with liver dysfunction preventable by oral neomycin. J Immunol, 200 (8): 2703-2713.

93. Choi J, Cooper ML, Staser K, Ashami K, Vij KR, Wang B, Marsala L, Niswonger J, Ritchey J, Alahmari B, Achilefu S, Tsunoda I, Schroeder MA, and DiPersio JF. (2018). Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor 2 for the prevention and treatment of graft-versus-host disease. Leukemia, 32 (11): 2483-2494.

94. Al-Kofahi　M, Omura S, Becker F, Tsunoda I, Sato F, Woolard MD, Gavins FNE, Pattillo, C, Shihab, I, Ghoweba, M, Wang Y, and Alexander JS. (2018). IL-1β Reduces Cardiac Lymphatic Muscle Contraction via COX-2 and PGE2 Induction: Potential Role in Myocarditis. Biomed Pharmacother, 107: 1591-1600.

95. Park A-M, and Tsunoda I. (2018). Forensic luminol reaction for detecting fecal occult blood in experimental mice. BioTechniques 65 (4): 227-230.

96. Park A-M, Tsunoda I, and Yoshie O. (2018). Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130. J Biol Chem 293 (41): 15815-15826.


97. Omura S, Kawai E, Sato F, Martinez NE, Minagar A, Al-Kofahi M, Yun JW, Cvek U, Trutschl M, Alexander, and Tsunoda I. (2018). Theiler’s virus-mediated immunopathology in the CNS and heart: Roles of organ-specific cytokine and lymphatic responses. Front Immunol, 9: 2870.

98. Omura S, Sato F, Martinez NE, Park A-M, Fujita M, Kennett NJ, Cvek U, Minagar A, Alexander JS, and Tsunoda I. (2019). Bioinformatics analyses determined the distinct CNS and peripheral surrogate biomarker candidates between two mouse models for progressive multiple sclerosis. Front Immunol, 10: 516.

99. Yun 　 JW, Cvek U, Kilgore PCSR I, Tsunoda I, Omura S, Sato F, Zivadinov R, Ramanathane M, Minagar A, and Alexander JS. (2019). Neurolymphatic biomarkers of brain endothelial inflammatory activation: Implications for multiple sclerosis diagnosis. Life Sci 229: 116-123.

II. BOOKS AND BOOK CHAPTERS

1. Tsunoda I and Fujinami RS. (1999). Theiler’s murine encephalomyelitis virus (TMEV). In: Persistent Viral Infections. Ahmed R and Chen ISY (Eds.), John Wiley & Sons, Ltd., Chichester, West Sussex, England, pp. 517-536. ISBN-10: 0471980838

2. Tsunoda I and Fujinami RS. (2005). TMEV and neuroantigens: Myelin genes and proteins, molecular mimicry, epitope spreading and autoantibody-mediated remyelination. In: Experimental Models of Multiple Sclerosis. Lavi E and Constantinescu CS (Eds.), Springer, New York NY. pp. 593-616.

3. Tsunoda I, Kobayashi-Warren, M, Libbey JE and Fujinami RS. (2009). Central nervous system degeneration caused by autoimmune cytotoxic CD8+ T cell clones and hybridomas. In: Encyclopedia of Neuroscience. Binder MD, Hirokawa N, Windhorst U (Eds), Springer-Verlag GmbH Berlin Heidelberg. pp. 619-625.

4. Sato F, Omura S, Martinez NE and Tsunoda I. (2011). Animal models for multiple sclerosis. In: Neuroinflammation. Minagar A (Ed), Elsevier, Burlington, MA. pp. 55-79. ISBN-10: 0123849136

5. Tsunoda I. (2016). Immune-mediated diseases in the central nervous system. In. Color Illustration Intensive Course. Immunology. Miyazawa M (Ed), Medical Review, Tokyo, Japan. in press.

6. Tsunoda I. (2016). Immune-mediated diseases in the peripheral nervous system. In. Color Illustration Intensive Course. Immunology. Miyazawa M (Ed), Medical Review, Tokyo, Japan. in press.

7. Sato F, Omura S, Jaffe S and Tsunoda I. (2016). Role of CD4+ T lymphocytes in pathophysiology of multiple sclerosis. In: Multiple Sclerosis: A Mechanistic View. Minagar A (Ed), Elsevier Inc., London, UK. pp. 41-69.


8. Sato F, Omura S, Martinez NE and Tsunoda I. (2018). Animal models for multiple sclerosis. In: Neuroinflammation (Second edition). Minagar A (Ed), Elsevier, Burlington, MA. pp. 37-72.

III. PROCEEDINGS

1. Terry EJ, Tsunoda I and Fujinami RS. (2004). Ultraviolet irradiation alters autoimmune responses, leading to disease progression in an animal model for multiple sclerosis. Proceedings of the NCUR 2004, pp. 1-8.

2. Tsunoda I, Tanaka T, Saijoh Y, Doyle SE, Terry EJ and Fujinami RS. (2007). Axonal damage targets inflammatory demyelinating lesions to sites of Wallerian degeneration: Inside-Out model for multiple sclerosis. In: Tabira T, Yamamura T, and Kira J (eds), 8 th

International Congress of Neuroimmunology. MEDIMOND S.r.l., Bolonga, Italy, 2007, pp. 37-40.

IV. OTHERS

1. Tsunoda I. (2011). Lab Report. Louisiana State University Health Sciences Center-Shreveport (LSUHSC-S). Jikken Igaku (Experimental Medicine), 29 (9): 1460-1462 (Japanese).

2. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2014). Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Elsevier B.V. Audioslides. http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.bbi.2014.07.008

3. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K and Tsunoda I. (2014). RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis in novel Th17-biased transgenic mice. Elsevier B.V. Audioslides. http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.jneuroim.2014.09.006

4. Sato F, Omura S, Kawai E, Martinez NE, Acharya MM, Reddy PC, Chaitanya GV, Alexander JS and Tsunoda I. (2014). Distinct kinetics of viral replication, T cell infiltration, and fibrosis in three phases of myocarditis following Theiler’s virus infection. Elsevier B.V. Audioslides. http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.cellimm.2014.10.004

http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.cellimm.2014.10.004

http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.cellimm.2014.10.004

http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.jneuroim.2014.09.006


http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.bbi.2014.07.008

http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.bbi.2014.07.008


5. Kawai E, Sato F, Omura S, Martinez NE, Reddy PC, Taniguchi M., and Tsunoda I. (2015). Organ-specific protective role of NKT Cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain. Elsevier B.V. Audioslides. http://audioslides.elsevier.com//ViewerLarge.aspx?source=1&doi=10.1016/j.jneuroim.2014.11.003

V. ABSTRACTS

1. Sako K, Iwasaki Y, Ohara Y, Tsunoda I and Okumura K. (1993). Anti-very late antigen-4 antibody suppresses acute active experimental allergic encephalomyelitis in Lewis rats. 69th Annual Meeting American Association of Neuropathologists, Salt Lake City, Utah, June 10-13, 1993. J. Neuropathol. Exp. Neurol. 52 (3): 310.

2. Ohara Y, Iwasaki Y, Terunuma H, Tsunoda I and Mizobuchi M. (1994). Latent infection of human T-cell Leukemia type I (HTLV-I) in human monocytic cell (THP-1). Tenth International Conference on AIDS, Yokohama, Japan, August 7-12, Abstract Book, Vol. 1, p. 136.

3. Terunuma H, Ohara Y, Mizobuchi M, Tsunoda I and Iwasaki Y. (1994). Transcriptional alteration of TNF- and IL-6 in an HIV-infected monocyte/macrophage lineage cell lines. Tenth International Conference on AIDS, Yokohama, Japan, August 7-12, Abstract Book, Vol. 2, p. 97.

4. Ohara Y, Iwasaki Y, Tsunoda I, Terunuma H and Mizobuchi M. (1994). Establishment of human monocytic cells (THP-1) infected with human T-cell leukemia virus type I (HTLV-I). XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 474.

5. Mizobuchi M, Sako K, Iwasaki Y, Ohara Y, Terunuma H and Tsunoda I. (1994). Suppression of acute active experimental allergic selective reduction of CD4+CD45RC cells in the peripheral blood in Lewis rats. XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 497.

6. Terunuma H, Ohara Y, Mizobuchi M, Tsunoda I and Iwasaki Y. (1994). Transcriptional activation of TNF- in HIV infected monocyte/macrophage lineage cell lines. XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 486.

7. Tsunoda I, Ohara Y, Sako K, Terunuma H, Mizobuchi M and Iwasaki Y. (1994). A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses




(TMEV). XIIth International Congress of Neuropathology, Toronto, Canada, September 18-23. Brain Pathol. 4 (4): 497.

8. Mizobuchi M, Iwasaki Y, Ohara Y, Terunuma H, Sako K, Tsunoda I, Kaneko Y, Mimura T and Okumura K. (1994). Suppression of acute active EAE with a derivative of mycophenolic acid. IVth International Congress of Neuroimmunology, Amsterdam, Netherland, October 23-27. J. Neuroimmunol. 54 (1-2): 183.

9. Tsunoda I, Kurtz CIB and Fujinami RS. (1996). Apoptosis as a possible mechanism for the central nervous system leading to demyelinating disease. Cell Biology of Virus Entry, Replication and Pathogenesis, Keystone Symposia on Molecular and Cellular Biology, Santa Fe, New Mexico, February 10-16, p. 45.

10. Tsunoda I, Kurtz CIB and Fujinami RS. (1996). Apoptosis in Theiler’s murine encephalomyelitis virus (TMEV) infection and experimental allergic encephalomyelitis (EAE). Society for Experimental Neuropathology, Miami, Florida, October 12-13. Brain Pathol. 6 (3): 257.

11. Tsunoda I, Tolley, ND, Whitten JL, Kuang L-Q and Fujinami RS. (1998). Enhancement of Theiler’s murine encephalomyelitis virus (TMEV) infection by immunization with plasmid DNA. The Fifth International Symposium on Positive Strand RNA Viruses, St. Petersburg, Florida, May 23-28, 1998.

12. Wada Y, McCright IJ, Whitby FG, Tsunoda I and Fujinami RS. (1998). Substitution of loop II of VP-1 of DA strain with loop II of the GDVII strain of Theiler’s murine encephalomyelitis virus alters neurovirulence, viral persistence and demyelination. EUROPIC ’98, Xth Meeting of the European Study Group on the Molecular Biology of Picornaviruses, Jena, Germany, September 5-11, Vol. 22.

13. Theil DJ, Tsunoda I, Libbey JE and Fujinami RS. (1999). Chemokine and cytokine mRNA expression in GDVII, DA and H101 strains of TMEV infection. Keystone Symposia on Molecular and Cellular Biology, Infections of the Nervous System: Host-Pathogen Interactions, Taos, New Mexico, March 9-14, p. 26.

14. Tsunoda I, Kuang L-Q, Theil DJ and Fujinami RS. (1999). Chronic progressive EAE induced with MOG peptide, possible role of NK1.1+ T cell and Th2-type immune response. Keystone Symposia on Molecular and Cellular Biology, Effects of Inflammation in the CNS, Taos, New Mexico, March 9-14, p. 58.

15. Tsunoda I, Cannon TS and Fujinami RS. (1999). Splenic autoreactive cytotoxic response in Theiler’s murine encephalomyelitis virus (TMEV) infection. American Society for Virology, 18th Annual Meeting, University of Massachusetts, Amherst, Massachusetts, July 10-14, pp. 79.

16. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2000). Viruses can silently prime and trigger autoimmune disease. 2000


FASEB Summer Research Conferences, Neural Immune Interactions in Injury and Disease: Pathways to Therapy. Copper Mountain, Colorado, June 18-23.

17. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2000). Viruses can silently prime for autoimmune CNS disease. Third International Symposium on NeuroVirology 2000, San Francisco, California, September 14-16, 2000. J NeuroVirol. 6 (5): 436.

18. Theil DJ, Tsunoda I, Rodriguez F, Whitton JL and Fujinami RS. (2001). Virus infections that protect against or silently prime and trigger autoimmune disease. Keystone Symposium on Molecular and Cellular Biology: Molecular Aspects of Viral Immunity, Keystone, Colorado April 17-22.

19. Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2002). Axonal injury heralds demyelination in Theiler’s murine encephalomyelitis virus infection, animal model for multiple sclerosis. American Society for Microbiology, 102nd General Meeting, Salt Lake City, Utah, May 19-23.

20. Libbey JE, Tsunoda I and Fujinami RS. (2002). Use of a BHK-21 cell mutant resistant to infection with Theiler’s murine encephalomyelitis virus to search for the receptor. American Society for Microbiology, 102nd General Meeting, Salt Lake City, Utah, May 19-23.

21. Tsunoda I and Fujinami RS. (2002) Induction of autoreactive CD8+ cytotoxic T cells during Theiler’s murine encephalomyelitis virus infection: Implications for Autoimmunity. Fourth International Symposium on Neurovirology/Tenth Conference on Neuroscience of HIV Infection (Conjoint Meeting), Düsseldorf, Germany, June 19-22.

22. Tsunoda I, Libbey JE, Igenge IZM and Fujinami RS. (2003). Lesion development from the axon (inside) to the myelin (outside) in Theiler’s virus infection, Inside-Out model: Retrograde axonal transport of toxic lectin targets inflammatory demyelinating lesions to the site of Wallerian degeneration. Fifth International Symposium of NeuroVirology--HIV Molecular and Clinical Neuroscience Workshop, Baltimore, Maryland, September 2-6. J. NeuroVirol. 9 (Suppl 3): 34.

23. Terry EJ, Tsunoda I and Fujinami RS. (2004). Ultraviolet irradiation alters autoimmune responses leading to disease progression in an animal model for multiple sclerosis. 18th National Conference on Undergraduate Research (NCUR), Indianapolis, Indiana, April 15-27, p. 40-41.

24. Fujinami RS and Tsunoda I. (2004). VP1 of TMEV is required for the generation of autoreactive T cells. American Society for Microbiology, 104th General Meeting, New Orleans, Louisiana, May 23-27.

25. Fujinami RS, Theil DJ, Tsunoda I, Jones MV and Whitton JL. (2004). Viruses Can Silently Prime or Protect and/or Trigger CNS Autoimmune Disease. 12 th International


Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23.

26. Fujinami RS. Theil DJ, Tsunoda I, Jones MV and Whitton JL. (2004). Viruses can silently prime and trigger CNS autoimmune disease. 6th International Symposium on NeuroVirology. Sardina, Italy, September 10-14, 2004. J. NeuroVirol., 10 (Suppl 3): 47-48, 2004

27. Peterson LK, Tsunoda I, Masaki T and Fujinami RS. (2004). Generation and characterization of natural autoantibodies in an animal model for multiple sclerosis. FASEB Summer Research Conferences. Neuro-Immune Interactions: Physiological and Pathological Relevance. Tucson, Arizona, August 7-12.

28. Tsunoda I, Tanaka T, Terry EJ and Fujinami RS. (2005). Is the lack of axonal injury in C57BL/Wlds mice beneficial or detrimental in animal models for multiple sclerosis? Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies. Keystone Symposium, Snowbird, Utah, January 11-15.

29. Kobayashi-Warren M, Tsunoda I, Kuang L-Q, Libbey JE and Fujinami RS. (2005). Interferon-γ ELISPOT assay for delineation of epitope specificity of autoreactive cytotoxic T cell clones and hybridomas established from Theiler’s virus infection. Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies. Keystone Symposium, Snowbird, Utah, January 11-15.

30. Peterson LK, Tsunoda I, Tanaka T, Masaki T and Fujinami RS. (2005). Polyreactivity, lymphocytotoxicity and CNS disease modulation by two MOG92-106 monoclonal antibodies. Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies. Keystone Symposium, Snowbird, Utah, January 11-15.

31. Carlson NG, Hill KE, Tsunoda I, Fujinami RS and Rose JW. (2005). Dying oligodendrocytes express COX-2 in Theiler’s virus infection, an animal model for MS. American Academy of Neurology, Miami Beach, Florida, April 9-16, 2005. Neurology 64 (6) Suppl 1: A84.

32. Tsunoda I, Libbey JE, Kobayashi-Warren M and Fujinami RS. (2005). TMEV infection leading to demyelination: Role for CD8+ autoreactive T cells. Third International Conference on Polyomaviruses and Human Diseases: Basic and Clinical Perspectives. Providence, Rhode Island, September 11-14, J. NeuroVirol. 11 (Suppl 2): 17

33. Smith MCP, Tanaka T, Kirkman NJ, McCoy LL, Tsunoda I and Fujinami RS. (2005). A novel infections animal model for seizure disorders. American Neurological Association 130th Annual Meeting. September 25-28, San Diego, California, Ann. Neurol. 58 (6).

34. Tsunoda I. Contrasting roles of axonal degeneration in autoimmune versus viral models for MS. (2006). The 2006 Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting. Scottsdale, Arizona, May 31-June 3.


35. Tsunoda I, Tanaka T, Saijoh Y, Doyle SE, Terry EJ and Fujinami RS. (2006). Axonal transport of toxic lectin from the PNS targets inflammatory demyelinating lesions to sites of Wallerian degeneration in the CNS in Theiler’s virus infection: Lesion development from the axon (inside) to the myelin (outside). The 8 th International Congress of Neuroimmunology, October 16-19, Nagoya, Japan. J. Neuroimmunol. 178 (Suppl 1): 73.

36. Fujinami RS, McCoy LL, Tsunoda I and Whitton JL. (2006). Viral infection and neurological diseases. The 8th International Congress of Neuroimmunology, October 16-19, Nagoya, Japan. J. Neuroimmunol., 178 (Suppl 1): 11.

37. Hasanovic F, Tsunoda I, Morrey JD, Siddharthan V and Fujinami RS. (2007). Detection of West Nile virus antigen in the brain using immunohistochemistry. UCUR 2007, February 2, Salt Lake City, Utah. UCUR 2007, abstract book, p. 96.

38. Tsunoda I, Tanaka T, Taniguchi M, Hasanovic F and Fujinami RS. (2008). Roles of CD1d-restricted V14+ NKT cells in Theiler’s virus infection, a viral model for multiple sclerosis. The 95th American Association of Immunologist (AAI) Annual Meeting at Experimental Biology 2008, San Diego, California, April 5-9, 2008. FASEB J. 22: 856.6.

39. Tsunoda I, Tanaka T, Hasanovic F and Fujinami RS. (2008). Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection. American Society for Investigative Pathology (ASIP) Annual Meeting at Experimental Biology 2008, San Diego, California, April 5-9. FASEB J. 22: 59.9.

40. Tsunoda I, Carlson NG, Rojas M, Hasanovic F and Rose JW. (2008). Treatment with a red wine component, resveratrol, in a virus-induced murine model for multiple sclerosis. World Congress on Treatment and Research in Multiple Sclerosis (WCTRIMS), ACTRIMS + ECTRIMS + LACTRIMS. Montreal, Canada, September 17-20. Mult. Scler. 14 (Suppl 1): S91.

41. Tsunoda I, Rose JW, Rojas M, Hasanovic F and Carlson NG. (2008). Treatment of an animal model for multiple sclerosis with resveratrol, a natural compound in red wine. 9th International Congress of NeuroImmunology. Forth Worth, Texas, October 26-30. J. Neuroimmunol. 203 (2): 247.

42. Tsunoda I, Carlson NG, Wood BL, Hasanovic F and Rose JW. (2009). Possible neural protection by a red wine component, resveratrol, in a viral model for multiple sclerosis. Keystone Symposium Multiple Sclerosis. Santa Fe, New Mexico, January 21-26, p78.

43. Fujinami RS and Tsunoda I. (2009). Viral infection of the CNS leads to CD8+ T cells with dual specificities to virus and self. Keystone Symposium Multiple Sclerosis. Santa Fe, New Mexico, January 21-26, p59.

44. Fujinami RS and Tsunoda I. (2009). Viral infection leads to CD8+ T cells with dual specificities to virus and self. The 9th International Symposium on NeuroVirology. Miami Beach, Florida, June 2-6, J. NeuroVirol. 15 (Suppl 1): p29-30.


45. Tsunoda I, Carlson NG, Wood BL, Hasanovic F and Rose JW. (2009). Possible neuroprotection by a red wine component, resveratrol, in CNS neurotropic virus infection. The 9th International Symposium on NeuroVirology. Miami Beach, Florida, June 2-6, J. NeuroVirol. 15 (Suppl 1): p100.

46. Tsunoda I, Carlson NG, Kirkman NJ, Doty DJ Saijoh Y and Rose JW. (2009). Inflammation, demyelination, neurodegeneration, and neuroprotection in the pathogenesis of a viral model for multiple sclerosis. A joint symposium supported by High-Tech Research Center Grant and Japan Health Sciences Foundation InternationalResearch Grant on Animal Models for Human Diseases. Izumisano, Osaka, Japan, June 13.

47. Sato F, Carlson NG, Rose JW, Wood BL, Martinez NE and Tsunoda I. (2010). Neuroprotection and suppression of IL-17A and IFN-gamma production by resveratrol, a red wine component, in neurotropic CNS Theiler's virus Infection. 2010 Louisiana NCRR/IDeA Biomedical Research Symposium, January 22, Baton Rouge, Louisiana.

48. Sato F, Carlson NG, Rose JW, Minagar A and Tsunoda I. (2010). Possible neuroprotection and Th17 modulation by a red wine component, resveratrol, in a mouse model for multiple sclerosis, Theiler’s virus infection. 62nd American Academy of Neurology, April 10-17, Toronto, Canada. Neurology 74 (9) Suppl 2: A561.

49. Sato F, Martinez NE, Carlson NG, Rose JW and Tsunoda I. (2010). Resveratrol, a red wine component, exacerbated MOG-induced EAE. The 10th International Congress of Neuroimmunology, October 26-30, Barcelona, Spain. J. Neuroimmunol. 228 (1-2): 95-96.

50. Greenlee JE, Clawson SA, Hill KE, Wood BL, Tsunoda I, and Carlson NG. (2010). Anti-Yo and anti-Hu antibodies affect different neuronal populations and induce cell death by different mechanisms in rat cerebellar slide cultures. The 10th International Congress of Neuroimmunology, October 26-30, Barcelona, Spain. J. Neuroimmunol. 228 (1-2): 189.

51. Sato F, Martinez NE, Omura S, Carlson NG, Rose JW and Tsunoda I. (2011). Resveratrol, a red wine component, exacerbated viral and autoimmune models for multiple sclerosis. Louisiana Biomedical Research Network (LBRN) 9th Annual Meeting, January 21-23, Shreveport, Louisiana.

52. Omura S, Sato F, Martinez, NE, Kennett NJ, and Tsunoda I. (2011). Roles of Th1 and Th17 cells in autoimmune and viral models for relapsing-remitting versus progressive multiple sclerosis. 63rd Annual Meeting of the American Academy of Neurology, April 9-16. Honolulu Hawaii. Neurology 76 (9) Suppl 4: A40.

53. Sato F, Martinez NE, Omura S, Carlson NG, Rose JW and Tsunoda I. (2011). Resveratrol, a red wine polyphenol compound, exacerbated autoimmune and viral models for multiple sclerosis with increased central nervous system inflammation. The Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, June 1-4, Montreal, Canada. Int. J. MS Care 13 (Suppl 3):15.


54. Omura S, Sato F, Martinez, NE and Tsunoda I. (2011). Is MS a homogenous or heterogenous disease? Insight from Th1 and Th17 cytokines in autoimmune and viral models for relapsing-remitting versus primary progressive multiple sclerosis. The Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, June 1-4, Montreal, Canada. Int. J. MS Care 13 (Suppl 3):13-14.

55. Martinez, NE, Karlsson F, Sato F, Omura S, Grisham MB and Tsunoda I. (2011). Regulatory T cells play a detrimental role in a viral model for multiple sclerosis. The Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting, June 1-4, Montreal, Canada. Int. J. MS Care 13 (Suppl 3):14.

56. Alexander JS, Ganta CV, Orr AW, Funk S, Yurdagul A, Cromer W, Mathis JM, Erdreich-Epstein A, Nagra RM, Minagar A, Tsunoda I, Sato F, Martinez N, and Omura S. (2011). Ephrin/Eph receptor expression on brain microvascular endothelial cells and microparticles: regulation by inflammatory cytokines. BrainPET2011. XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET. May 24-28, Barcelona, Spain.

57. Sato F, Martinez NE, Omura S, Alexander JS and Tsunoda I. (2011). Curdlan, a Th17 cell inducer, was both detrimental and protective in Theiler's virus infection. The International Union of Microbiological Societies (IUMS). XV International Congress of Virology, September 6-16, Sapporo, Japan.

58. Martinez, NE, Karlsson F, Sato F, Omura S, Grisham MB and Tsunoda I. (2011). Regulatory T cells play a detrimental role in a viral model for multiple sclerosis. The International Union of Microbiological Societies (IUMS). XV International Congress of Virology, September 6-16, Sapporo, Japan.

59. Sato F, Martinez NE, Omura S, Alexander JS and Tsunoda I. (2011). Effect of curdlan, a Th17 cell inducer, on a viral model for multiple sclerosis. The 23rd

Annual Meeting of the Japanese Society for Neuroimmunology, September 15-17, Tokyo, Japan, p80.

60. Omura S, Sato F, Martinez NE, Kennett NJ, Alexander JS and Tsunoda I. (2011). System biology analysis of microarray data from animal models for relapsing-remitting versus primary progressive multiple sclerosis. The 23rd Annual Meeting of the Japanese Society for Neuroimmunology, September 15-17, Tokyo, Japan, p67.

61. Martinez, NE, Karlsson F, Sato F, Omura S, Grisham MB and Tsunoda I. (2011). Contrasting roles of regulatory T cells in the Theiler’s virus model for multiple sclerosis. Regulatory T cells play a detrimental role in a viral model for multiple sclerosis. Southeast Regional IDeA Meeting, September 22-24, 2011, New Orleans, Louisiana.

62. Sato F, Martinez NE, Omura S, Alexander JS and Tsunoda I. (2011). Curdlan, a Th17 cell inducer, plays contrasting roles in Theiler's virus infection. Southeast Regional IDeA Meeting, September 22-24, 2011, New Orleans, Louisiana.


63. Martinez NE, Karlsson F, Sato F, Omura S, Minagar A, Grisham MB and Tsunoda I. (2011). Regulatory T cells play contrasting roles in a viral model for multiple sclerosis. The American Neurological Association (ANA) 136th Annual Meeting, September 25-27, 2011, San Diego, California. Ann. Neurol. 70 (Suppl 15): S90-1.

64. Tsunoda I, Omura S, Sato F, Martinez NE, Karlsson F, Grisham MB, Chaitanya GV and Alexander JS. (2011). Theiler’s virus infection: Animal models for multiple sclerosis and myocarditis. American Society for Microbiology (ASM) South Central Branch Annual Meeting, December 2-3, 2011, Monroe, Louisiana.

65. Sato F, Omura S, Martinez NE, Chaitanya GV, Alexander JS and Tsunoda I. (2011). Role of Toll-like receptor (TLR)4 in a viral model for myocarditis. American Society for Microbiology (ASM) South Central Branch Annual Meeting, December 2-3, 2011, Monroe, Louisiana.

66. Sato F, Martinez E, Omura S, Alexander S, Minagar A and Tsunoda I. (2012). Curdlan, a Th17 cell inducer, plays contrasting roles in viral model for multiple sclerosis. 64th Annual Meeting of the American Academy of Neurology, April 21-28. New Orleans, Louisiana. Neurology 78 (Suppl 1): P05113.

67. Omura S, Sato F, Martinez NE, Kawai E, Trutschl M, Cvek U and Tsunoda I. (2012). Bioinformatics analysis of microarray data in cardiomyocytes and neuronal cells infected with Theiler’s virus. NIH, NIGMS Fourth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). June 25 – 27, 2012, Washington, DC.

68. Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K and Tsunoda I. (2012). Th17 bias renders mice susceptible to virus-induced demyelinating disease. NIH, NIGMS Fourth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). June 25 – 27, 2012, Washington, DC.

69. Rollyson P, Tsunoda I, Omura S Trutschl M and Cvek U. (2012). Combining visualization with data mining for bioinformatics-driven discovery. NIH, NIGHS Fourth Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE). June 25 – 27, 2012, Washington, DC.

70. Sato F, Omura S, Martinez NE, Kawai E, Chaitanya GV, Alexander JS and Tsunoda I. (2012). Detrimental role of Toll-like receptor 4 in cardiovirus-induced myocarditis. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2012 Scientific Sessions. July 23-26, 2012. New Orleans, Louisiana. Circ. Res. 111 (4, Suppl S): 116.

71. Kawai E, Omura S, Sato, F, Martinez NE, Chaitanya GV, Claycomb WC, Alexander JS and Tsunoda I. (2012). Chemokine and autophagy-related genes in novel in vivo and in vitro models for viral myocarditis. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2012 Scientific Sessions. July 23-26, 2012. New Orleans, Louisiana. Circ. Res. 111 (4, Suppl S): 333.

72. Omura S, Sato F, Martinez NE, Chaitanya GV, Claycomb WC, Alexander JS and Tsunoda I. (2012). Upregulation of chemokines and interferon-associated genes in a


novel model for myocarditis induced by cardiovirus infection. 31st Annual Meeting of the American Society for Virology (ASV). July 21-25, 2012. Madison, Wisconsin. Scientific Program & Abstracts, p144.

73. Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, and Tsunoda I. (2012). Th17 bias renders mice susceptible to a viral model for multiple sclerosis. 11th

International Society for Neuroimmunology (ISNI) Congress. November 5-8, 2012, Boston, MA. J. Neuroimmunol. 253 (1-2): 105-106.

74. Greenlee JE, Clawson S, Wood B, Hill K, Tsunoda I, and Carlson NG. (2013). Comparative uptake and cytotoxicity of anti-Hu and anti-Ri antibodies in rat cerebellar slice cultures. American Academy of Neurology 65th Annual Meeting, March 16-23, 2013, San Diego, California. Neurology 80 (Suppl): P02.161.

75. Omura S, Sato F, Kawai E, Martinez NE, Pearson SF, Rollyson P, Cvek U, Trutschl M and Tsunoda I. (2013). Computational analysis of microarray gene expression patterns discriminates the acute viral versus subacute immune phases of myocarditis induced by cardiovirus. 32nd Annual Meeting of the American Society for Virology (ASV). July 20-24, 2013. State College, Pennsylvania. Scientific Program & Abstracts, p179.

76. Sato F, Omura S, Martinez NE, Kawai E, Pearson SF, Fernando V, Acharya MM, Ganta CV, Alexander JS, Ajuebour MN, Taniguchi M, and Tsunoda I. (2013). Natural killer T cells play protective roles in cardiovirus-induced myocarditis by induction of anti-viral and regulatory cytokines. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2013 Scientific Sessions. July 22-25, 2013. Las Vegas, Nevada. Circ. Res. 113 (4 Sppl):039.

77. Kawai E, Omura S, Sato F, Martinez NE,　Fernando V, Rollyson P, Cvek U, Trutschl M, and Tsunoda I. (2013). Determination of phase-specific biomarkers of viral myocarditis induced by Theiler’s virus using multivariate analyses of viral genome, troponin, transcriptome and echocardiography data. American Heart Association (AHA), Basic Cardiovascular Sciences (BCVS) 2013 Scientific Sessions. July 22-25, 2013. Las Vegas, Nevada. Circ. Res. 113 (4 Sppl):229.

78. Al-Kofahi M, Alexander JS, Woolard M, Tsunoda I, Wang Y, Boktor M, Jordan PA, Sheth A, Zawieja DC, Muthuchamy M, von der Weid P-Y, Ostanin D, Pinto K, and Becker F. (2014). IL-1β inhibits contraction of intestinal lymphatic smooth muscle - Implications for chronic gut inflammation. Digestive Disease Weak (DDW) 2014, May 3-6, 2014. Chicago, Illinois. Gastroenterology 146 (5, Suppl 1): S830.

79. Shafiei F, Omura S, Kawai E, Sato F, Martinez NE, Fernando V, Morris L, Alexander JS, Cvek U, Trutschl M, and Tsunoda I. (2014). Computational multivariate analyses for phase-specific biomarker identification in novel in vivo and in vitro viral myocarditis models induced by cardiovirus. 63rd Annual Scientific Session & Expo of the American College of Cardiology (ACC.14). March 29-31, 2014. Washington, DC. J. Am. Coll. Cardiol. 63 (12 Suppl): A971.

80. Omura S, Cvek U, Trutschl M, Sato F, Martinez NE, Kawai E, Fernando V, Morris LA, Acharya M, Shafiei F, Alexander JS and Tsunoda I. (2014). Brain biomarkers and


spleen surrogate markers for primary progressive MS models. International Workshop and Oral Presentation: MS Model 1, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

81. Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K and Tsunoda I. (2014). Th17 biased transgenic mice show exacerbation of an autoimmune model for MS. International Workshop and Oral Presentation: MS Model 1, the 55 th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

82. Sato F, Fernando V, Omura S, Martinez NE, Kawai E, Shafiei F, Acharya MM, Takahashi S, Yoh K and Tsunoda I. (2014). Autoimmune and viral models of MS in Th2-biased GATA3 transgenic mice. International Workshop and Oral Presentation: MS Model 1, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

83. Tsunoda I, Martinez NE, Omura S, Kawai E and Sato F. (2014). Inside-Out model of multiple sclerosis: Theiler’s virus infection. International Workshop and Oral Presentation: MS Model 2, the 55th Annual Meeting of the Japanese Society of Neurology. May 21-24, 2014. Fukuoka, Japan.

84. Omura S, Sato F, Kawai E, Martinez NE, Cvek U, Trutschl M, Alexander JS and Tsunoda I. (2014). Phase-specific cardiac biomarkers and blood surrogate markers for a mouse model of myocarditis induced by cardiovirus. 33rd Annual Meeting of the American Society for Virology (ASV). June 21-25, 2014. Fort Collins, Colorado. Scientific Program & Abstracts, p161.

85. Greenlee JE, Clardy SL, Clawson SA, Wood B, Hill KE, Tsunoda I, and Carlson NG. (2014). Specificity of antibody binding in anti-Yo antibody mediated Purkinje cell cytotoxicity. 139th Annual Meeting, American Neurological Association (ANA), October 12-14, Baltimore, Maryland. Ann. Neurol. 76 (Suppl 18), S78, 2014

86. Stevenson EV, Yun JW, Omura S, Sato F, Tsunoda I, Minagar A, Becker F, Castor T, Couraud P-O, Romero IA, Weksler B, and Alexander JS. (2015). Fluid dynamic influences on Cerebrovascular endothelial activation responses. 5th Annual Meeting of the International Society for Neurovascular Disease (ISNDV), March 27-29, Naples, Italy. Program Book, p22.

87. Yun JW, Stevenson E, Omura S, Sato F, Tsunoda I, Minagar A, Becker F, Castor T, Xiao A, and Alexander JS. (2015). Endothelial dysfunction in neurodegenerative disease. 5th Annual Meeting of the International Society for Neurovascular Disease (ISNDV), March 27-29, Naples, Italy. Program Book, p29.

88. Becker F, Witte M, Boktor M, Tsunoda I, Jordan PA, Bernas M, Abreo F, Orr AW, and Alexander JS (2015). Reduced intestinal leukocyte exit heightens the severity of DSS colitis in a murine model of lymphovascular deficiency. Digestive Disease Week (DDW) 2015, May 16-19, 2015. Washington DC. Gastroenterology 148 (4, Suppl 1): S-721.

89. Al-Kofahi M, Becker F, Wang Y, Tsunoda I, Woolard M, Jordan PA, Boktor M, and Alexander JS (2015). IL-1 receptor antagonist (Anakinra) restores mesenteric lymphatic


muscle cell tonic contractility suppressed by acute or chronic colitis conditioned media in vitro. Digestive Disease Week (DDW) 2015, May 16-19, 2015. Washington DC. Gastroenterology 148 (4, Suppl 1): S-693.

90. Sato F, Kawai E, Martinez NE, Omura S, Cliburn EA, Takahashi S, Yoh K, and Tsunoda I. (2015). Th1 transcription factor T-bet, but not the Th2 transcription factor GATA3, overexpression is detrimental in neurotropic viral infection in the CNS. 34th Annual Meeting of the American Society for Virology (ASV). July 11-15, 2015. London, Ontario, Canada.

91. Sato F, Kawai E, Martinez NE, Omura S, Stewart EC, Takahashi S, Yoh K, and Tsunoda I. (2015). Th1/Th2 imbalance by “gain-of-function” mutations cause fatal Theiler’s virus infection in mice. 2015 Southeast Regional IDeA Meeting. November 11-13, 2015. Biloxi, Mississippi.

92. Becker F, Gavins FN, Vowinkel T, Tsunoda I, Rijcken E, Ostanin DV, and Alexander JS. (2016). Contributions of monocytes to gut inflammation in acute and chronic colitis models. 11th Congress of European Crohn’s and Colitis Organization (ECCO). March 16-19, 2016. Amsterdam, Netherlands.

93. Yun JW, Minagar A, Tsunoda I, and Alexander JS. (2016). Brain endothelial cells segregate lymphatic-venous biomarkers into microparticles following inflammatory cytokine stimulation. Experimental Biology 2016, April 2-6, 2016, San Diego, California. FASEB J 30 (1, Suppl): 993:9.

94. Becker F, Vowinkel T, Rijcken E, Tsunoda I, Ostanin DV and Alexander JS. (2016). Monocytes/macrophages play a contributing role in lymphangiogenesis independent of their role in intestinal inflammation. 133. Kongress Deutsche Gesellschaft für Chirurgie. April 26-29, 2016. Berlin, Germany.

95. Omura S, Sato F, Alexander JS, Kilgore PCSR, Cvek U, Trutschl M, and Tsunoda I. (2016). Upregulation of lymphatic markers and vascular adhesion molecules in CNS RNAseq transcriptome of a viral model for multiple sclerosis. The 6 th Annual International Society for Neurovascular Disease (ISNVD) Scientific Meeting, April 29-30, 2016. Ney York, New York.

96. Minagar A, Tsunoda I, and Alexander JS. (2016). Multiple sclerosis as a vascular disease. The 6th Annual International Society for Neurovascular Disease (ISNVD) Scientific Meeting, April 29-30, 2016. Ney York, New York.

97. Sato F, Omura S, Park A-M, Fujita M, Stokes KY, and Tsunoda I. Viral infection activates myelin-specific T cells, triggering MS-like CNS inflammatory demyelination. XXIII World Congress of Neurology, September 16-21, 2017. Kyoto, Japan. J. Neurol. Sci. 381 (Suppl): 1057-1058.

98. Omura S, Sato F, Martinez NE, Cvek U, Minagar A, Alexander JS, and Tsunoda I. Bioinformatics analysis determined the CNS and peripheral lymphoid surrogate biomarker candidates between two distinct EAE models for progressive multiple sclerosis. XXIII World Congress of Neurology, September 16-21, 2017. Kyoto, Japan. J. Neurol. Sci. 381 (Suppl): 794-795.


99. Omura S, Shimizu K, Morikawa M, Kuwahara M, Kawamura T, Mori T, Kusunoki S, and Tsunoda I. (2017). Factor Analysis Associated Anti-Glycolipid Antibodies with Clinical Data in Guillain-Barré Syndrome. Informatics in Biology, Medicine and Pharmacology (IBMP2017). September 27-29, 2017. Sapporo, Japan. 第 6 回生命医薬情報学連合大会。北海道大学。

100. Sato 　 F, Martinez NE, Omura S, Park A-M, Fujita M, and Tsunoda I. (2017). Protective and detrimental effects of curdlan, a Th17 cell inducer, in immune-mediated demyelination induced by a neurotropic viral infection. The 46 th Annual Meting of the Japanese Society for Immunology. December 12-14, 2017. Sendai International Center, Sendai, Japan.

101. Omura S, Sato F, Park A-M, Fujita M, Alexander JS, Kilgore PCSR, Cvek U, Tsunoda I. (2018). Bioinformatics analyses identified phase-specific heart biomarkers and blood surrogate markers for a mouse model of viral myocarditis. Louisiana Biomedical Research Network (LBRN) 16th Annual Meeting, January 10, 2018, Louisiana State University Health Sciences Center (LSUHSC)-Shreveport, Shreveport, Louisiana.

102. Tsunoda I, Omura S, Sato F, Park A-M, Fujita M, Sakiyama N, Minagar A, Kilgore PCSR, Cvek U and Alexander JS. (2018). Neurotropic virus infection downregulates lymphatic molecules, suppressing lymphocyte exit from the central nervous system. The 12th China-Japan International Conference of Virology, May 17-19, 2018. Wuhan, PR China. Abstract book, p56.　

103. Sato F, Martinez NE, Omura S, Park A-M, Fujita M, Minagar A, Alexander JS, and Tsunoda I. (2018). Potential prebiotic β-glucan curdlan differently alters viral versus autoimmune models of MS. The 8th Sendai Conference 2018. July 14, 2018. Abstract book, p9.

104. Omura S, Shimizu K, Kuwahara M, Morikawa M, Fujita M, Park A-M, Sato F, Kusunoki S, and Tsunoda I. (2018). Distinct sets of anti-glycolipid antibodies are associated with latent factors in Guillain-Barré syndrome by exploratory factor analysis. 14th International Congress of Neuroimmunology (ISNI 2018). August 27-31, 2018. Brisbane Convention & Exhibition Centre (BCEC), Brisbane, Australia.

105. Omura S, Sato F, Park A-M, Fujita M, Alexander JS, Kilgore PCSR, Cvek U, Tsunoda I. (2018). Bioinformatics analyses identified phase-specific heart biomarkers and blood surrogate markers for a mouse model of viral myocarditis. Research and Industry Day (RAID) 2018 Conference, October 26, 2018, Louisiana Tech Shreveport Center, Shreveport, Louisiana.

106. Kanai K, Park A-M, Tsunoda I, and Yoshie O. (2018). A Severe Infectious Mononucleosis-Like Disease in IL-27-Deficient Mice Infected with Murine γ-Herpesvirus 68. The 66th Annual Meeting of the Japanese Society for Virology. October 28-30, 2018. Kyoto Terrsa, Kyoto, Japan.

107. Sato F, Omura S, Martinez NE, Cliburn EA, Acharya MM, Reddy PC, Alexander JS, and Tsunoda I. (2018). Theiler’s virus-induced myocarditis model with acute viral


replication, subacute T cell infiltration and chronic fibrosis in the heart. The 66th Annual Meeting of the Japanese Society for Virology. October 28-30, 2018. Kyoto Terrsa, Kyoto, Japan.

108. Khadka S, and Tsunoda I. (2018). New diagnostic algorithm of HIV/AIDS in Nepal. 4th Dianken Microbiology Colloquium, October 31, 2018, Osaka Institute of Public Health, Osaka, Japan.

109. Sato F, Omura S, Kawai E, Martinez N.E, Acharya MM, Reddy PC, Alexander JS, and Tsunoda I. (2018). TLR4 exacerbates a novel model of myocarditis induced with a picornavirus. The 47th Annual Meeting of the Japanese Society for Immunology, December 10-12, 2018. Fukuoka International Congress Center, Fukuoka, Japan.

110. Omura S, Nishio K, and Tsunoda I. (2019). Communication between CNS and gut microbiota in a viral model for multiple sclerosis. The 1st International Symposium on Chemical Communication (ISCC2019), January 9-10, 2019. National Center of Sciences Building, Tokyo, Japan. Program and Abstracts book, p46.

VI. ORAL PRESENTATIONS (INVITED)

1. XIIth International Congress of Neuropathology. “A comparative study on acute and chronic diseases induced by two subgroups of Theiler's murine encephalomyelitis viruses (TMEV).” Toronto, Canada, September 18-23, 1994.

2. Keystone Symposia on Molecular and Cellular Biology, Cell Biology of Virus Entry, Replication and Pathogenesis. “Apoptosis as a possible mechanism for elimination of virus infected cells from the central nervous system leading to demyelinating disease.” Santa Fe, New Mexico, February 10-16, 1996.

3. Biology of Neurologic Disease Meeting, Society for Experimental Neuropathology. “Apoptosis in Theiler's murine encephalomyelitis virus (TMEV) infection and experimental allergic encephalomyelitis (EAE).” Miami, Florida, October 12-13, 1996.

4. The Fifth International Symposium on Positive Strand RNA Viruses. “Enhancement of Theiler’s murine encephalomyelitis virus (TMEV) infection by immunization with plasmid DNA.” St. Petersburg, Florida, May 23-28, 1998.

5. Fukushima Medical University School of Medicine. “Exacerbation of viral and autoimmune models for multiple sclerosis by bacterial DNA.” Fukushima, Japan, April 19, 1999.


6. Keystone Symposium on Molecular and Cellular Biology: Effects of Inflammation in the CNS. “Chronic progressive EAE induced with MOG peptide: Possible role of NK1.1+ T cell and Th2-type immune response.” Taos, New Mexico, March 9-14, 1999.

7. American Society for Virology, 18th Annual Meeting. “Splenic autoreactive cytotoxic response in Theiler’s murine encephalomyelitis virus (TMEV) infection.” University of Massachusetts, Amherst, Massachusetts, July 10-14, 1999.

8. American Society for Microbiology, 102nd General Meeting. “Axonal injury heralds demyelination in Theiler’s murine encephalomyelitis virus infection, animal model for multiple sclerosis.” Salt Lake City, Utah, May 19-23, 2002.

9. Fifth International Symposium of NeuroVirology--HIV Molecular and Clinical Neuroscience Workshop. “Lesion development from the axon (inside) to the myelin (outside) in Theiler’s virus infection, Inside-Out model: Retrograde axonal transport of toxic lectin targets inflammatory demyelinating lesions to the site of Wallerian degeneration.” Baltimore, Maryland, September 2-6, 2003.

10. Iwate Medical College. Neuroscience seminar. “Inside-Out versus Outside-In models for virus induced demyelination: Axonal damage triggering demyelination.” Morioka, Iwate, Japan November 18, 2004.

11. Fukushima Medical University School of Medicine. “Axonal injury in animal models of multiple sclerosis.” Fukushima, Fukushima, Japan, November 22, 2004.

12. Tohoku University School of Medicine. “Retrograde axonal transport of toxic lectin targets inflammatory demyelinating lesions to the site of Wallerian degeneration.” Sendai, Miyagi, Japan, November 25, 2004.

13. Multiple Sclerosis Update. “The Inside out model of multiple sclerosis.” Salt Lake City, UT, May 20-21, 2005

14. Fukushima Medical University School of Medicine. ”Autoreactive cytotoxic CD8+ T cells in Theiler’s murine encephalomyelitis virus infection” Fukushima, Fukushima, Japan, November, 17, 2005

15. Molecular Medical Science Institute, Otsuka Pharmaceutical Co. Ltd. “Multiple Sclerosis and Axon Injury.” Tokushima, Tokushima, November 21, 2005.

16. Kinki University School of Medicine. “Axonal injury in multiple sclerosis: Inside-Out model.” Osakasayama, Osaka, November 22, 2005.

17. The 2006 Consortium of Multiple Sclerosis Centers Annual Meeting. “Contrasting roles of axonal degeneration in autoimmune versus viral models for MS.” Scottsdale, AZ, May 31-June3, 2006.


18. Iwate Medical College. “Autoimmune Cytotoxic CD8+ T cells in Theiler’s Murine Encephalomyelitis Virus Infection.” Morioka, Iwate, Japan October 10, 2006.

19. The 8th International Congress of Neuroimmunology. “Axonal transport of toxic lectin from the PNS targets inflammatory demyelinating lesions to sites of Wallerian degeneration in the CNS in Theiler’s virus infection: Lesion development from the axon (inside) to the myelin (outside).” October 16-19, 2006, Nagoya, Japan.

20. The Brain Institute, The University of Utah, Multiple Sclerosis Research in Utah. “Does axonal degeneration precede demyelination in MS? An Inside-Out model.” Salt Lake City, Utah, October 18, 2007.

21. Hokkaido University. “Contrasting roles of axonal degeneration in virus infection and autoimmune disease. Animal models for multiple sclerosis and post-polio syndrome.” Sapporo, Hokkaido, Japan. October 24, 2007.

22. Second Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd. “Can axonal degeneration be beneficial or detrimental in an autoimmune versus viral model of multiple sclerosis?” Tokushima, Tokushima, Japan. October 30, 2007.

23. Kinki University Medical Association. “Axonal degeneration in viral and autoimmune models for multiple sclerosis. ” Osakasayama, Osaka, Japan. October 21, 2007.

24. The 13th Neuroscience Seminar, The Juzen Medical Society Kanazawa University. “Contrasting roles of axonal degeneration in viral and autoimmune models for multiple sclerosis.” Kanazawa, Ishikawa, Japan. November 6, 2007.

25. American Society for Investigative Pathology (ASIP) Annual Meeting at Experimental Biology 2008. “Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection.” San Diego, California, April 5-9, 2008.

26. Institut Pasteur of Shanghai, Chinese Academy of Sciences. “Can axonal degeneration be beneficial or detrimental in neurotropic virus infection and autoimmune encephalitis?” Shanghai, China. June 2, 2008.

27. The University of Cincinnati, Neurology Grand Rounds “Axonal degeneration in viral and autoimmune models for multiple sclerosis: Inside-Out model.” Cincinnati, Ohio, January 14, 2009.

28. Tohoku University Graduate School of Medicine. “Axonal degeneration in neurotropic virus infection.” Sendai, Miyagi, Japan, January 27, 2009.


29. Hiroshima University School of Medicine. “Compartmental neurodegeneration as a protection mechanism against neurotropic virus infection.” Hiroshima, Hiroshima, Japan, January 29, 2009.

30. Kinki University School of Medicine. “Autoimmune cytotoxic CD8+ T cells in Theiler’s virus infection.” Osakasayama, Osaka, Japan, January 30, 2009.

31. The 483rd Brain Institute Conference, Kyushu University School of Medicine. ”Axonal degeneration in viral and autoimmune models for multiple sclerosis: Inside-Out model.” Hakata, Fukuoka, Japan, February 2, 2009.

32. Louisiana State University Health Sciences Center. “Axonal degeneration as a self-destructive defense mechanism against neurotropic virus.” Shreveport, Louisiana, February 10, 2009.

33. High-Tech Research Center Grant and Japan Health Sciences Foundation International Research Grant on Animal Models for Human Diseases. “Inflammation, demyelination, neurodegeneration, and neuroprotection in the pathogenesis of a viral model for multiple sclerosis.” Izumisano, Osaka, Japan, June 13, 2009.

34. Research Institute of Environmental Medicine, Nagoya University. “Axonal degeneration in animal models for multiple sclerosis: Inside-Out model.” Nagoya, Aichi, Japan, June 15, 2009.

35. Tohoku Medical Society. “Axonal degeneration in viral and autoimmune models for multiple sclerosis: Inside-Out model.” Sendai, Miyagi, Japan, June 18, 2009.

36. The University of Basel. "Genetic Approaches in Medical Research" Lecture Series. ”Axonal degeneration in autoimmune and viral models for multiple sclerosis: Inside-Out model.” Basel, Switzerland, October 22, 2010.

37. The 330th Tsukuba Molecular Life Science Seminar. “Resveratrol, a red wine component, exacerbates autoimmune and viral models for multiple sclerosis.” Tsukuba Society for Molecular Medicine/TSMM, University of Tsukuba, Tsukuba, Ibaraki, Japan. September 9, 2011.

38. Hokkaido University Health Sciences Seminar. “Axonal degeneration in autoimmune and viral models for multiple sclerosis: Inside-Out model.” Faculty of Health Sciences, Hokkaido University, Sapporo, Japan. September 12, 2011.

39. Asahikawa Medical College. “Resveratrol, a red wine component, exacerbates autoimmune and viral models for multiple sclerosis.” Department of Medicine, Asahikawa Medical College, Asahikawa, Japan. September 13, 2011.

40. South Central Branch American Society for Microbiology (ASM) Annual Meeting. “Theiler’s virus infection: Animal models for multiple sclerosis and myocarditis.” Monroe, Louisiana, December 2, 2011.


41. Texas Tech University Health Sciences Center. Biomedical Sciences Biomedical Seminar Series. “Theiler’s virus infection: Animal models for multiple sclerosis and myocarditis.” Lubbock, Texas, November 14-16, 2013.

42. Kinki University Medical Association. “The role of Th17 and regulatory T cells in viral and autoimmune models for multiple sclerosis. ” Osakasayama, Osaka, Japan. May 19, 2014.

43. International Workshop and Oral Presentation: MS Model 2, the 55 th Annual Meeting of the Japanese Society of Neurology. “Inside-Out model of multiple sclerosis: Theiler’s virus infection.” Fukuoka, Japan, May 21-24, 2014.

44. University at Buffalo, the State University of New York, Neurology Grand Rounds. “A viral model for multiple sclerosis; Theiler’s virus infection.” Buffalo, New York, May 7, 2015.

45. Multiple Sclerosis Summit. University of Utah. “Models of MS and Disease Progression”. Salt Lake City, Utah, December 5, 2015.

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