curriculum vitae april, 2017 name: violeta n. mutafova ... · pharmacology (fogarty center fellow...

Mutafova-Yambolieva, Violeta

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CURRICULUM VITAE April, 2017

NAME: VIOLETA N. MUTAFOVA-YAMBOLIEVA, M.D., Ph.D. POSITION: Professor ADDRESS: Department of Physiology and Cell Biology Center for Molecular Medicine University of Nevada School of Medicine 1664 N. Virginia Street Reno, NV 89557-0575 Phone: +1 (775) 784-6274 Fax: +1 (775) 784-6903 Email: [email protected] Website: http://med.unr.edu/directory/violeta-mutafova-yambolieva

EDUCATION

Post-doc, Feb 1995- Jun 1996, University of Nevada School of Medicine Reno, Department of Physiology and Cell Biology, Mentor: Kathleen Keef, Ph.D.

Post-doc, Sep 1993-Jan 1995, University of Nevada School of Medicine Reno, Department of Pharmacology (Fogarty Center fellow NIH), Mentor: David P. Westfall, Ph.D.

Ph.D., 1987, Medical Academy Sofia, Bulgaria Thesis: Mechanisms of hypotensive action of one tetraline derivative. Thesis advisor: Dushka Staneva-Stoytcheva, M.D., Ph.D.

Specialty Pharmacology, 1982-1986, Medical Academy Sofia, Bulgaria

M.D., 1978, Medical Academy, Sofia, Bulgaria

PROFESSIONAL APPOINTMENT

Professor (2008-present), Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV

Associate Professor (2002-2008), Department of Physiology and Cell Biology, University of Nevada School of Medicine

Research Associate Professor (2000-2002), Department of Physiology and Cell Biology, University of Nevada School of Medicine

Research Assistant Professor (1997-2000), Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, Nevada

Postdoctoral Fellow (1996-1997), Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, Nevada


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Postdoctoral Fellow (1993-1995), Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada.

Assistant Professor (1987-1993), Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

Research Fellow (1982-1987), Department of Pharmacology and Toxicology, Medical Academy, Sofia, Bulgaria

Attending Physician (1979-1982), Department of Internal Medicine (emphasized training in Cardiology and ICU), alternating primary care with specialized clinical care, District Hospital Svishtov, Bulgaria

ADDITIONAL TRAINING

Advanced Experimental Pharmacokinetics (1984), Medical Academy, Sofia, Bulgaria

Fogarty International Fellowship (1993-1995), Neurochemistry approaches to study neurotransmitter release, University of Nevada School of Medicine, Reno, Nevada, U.S.A

Electrophysiological approaches to smooth muscle research (1996-1997), University of Nevada School of Medicine, Reno, Nevada, U.S.A.

PROFESSIONAL DEVELOPMENT ACTIVITIES

2011 Workshop “Self-directed learning” according to Stanford University model, Nageshwara Gullapalli, UNSOM, Reno, November 16, 2011

2011 Workshop on medical education curriculum reform in UCLA, February 2011

2010 Workshop “Case Development Strategies: Facilitating Learning for Students” by Dr. Joel Michael, UNSOM, Reno, NV, November 1, 2010.

2003 Discussions for the book Teaching College in an Age of Accountability (Allyn & Bacon, 2003)

2000 Workshop “Guiding Your Course to Success”, UNR, October 20-21, 2000

AWARDS

1999 Digestive Disease Week, Orlando, Florida, May 16-19, 1999, DDW Poster of Distinction

1993 Fogarty International Fellowship (NIH), Recipient

1991 Academician Puhlev Award, Bulgarian Academy of Sciences

1988 First prize “Best Young Pharmacologist”, Bulgarian Pharmacological Society

1981 Award for High Proficiency, Board of District Hospital, Svishtov

1978 Gold medal, Medical Academy (the highest prize in Bulgaria for medical students)

1977 First Prize for Science and Technology (the highest prize in Bulgaria for young scientists)


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1976 First Prize at National Science Competition for Undergraduate Students

RESEARCH AND SCHOLARLY ACTIVITIES

A. KEYWORDS/AREAS OF RESEARCH INTEREST: neurobiology, smooth muscle, neurochemistry, autonomic nervous system, neural control of vascular and visceral smooth muscles, neurotransmitter release and removal, cotransmission, purinergic neurotransmission, purinergic signaling, signal transduction, hypertension, overactive bladder, gastro-intestinal motility disorders

B. GRANT SUPPORT

Mechanosensitive mechanisms regulating bladder function Program Project Grant P01-DK, 2014-2019 PI: Kenton M. Sanders, SD Koh Project 3: “Mechanosensitive release, transport and function of purines during bladder filling” Role: Leader of Project 3 Pending

Regulatory Mechanisms in Intestinal Motility Program Project Grant P01-DK41315, 2014-2019 PI: Kenton M. Sanders Project 3: “Novel mechanisms in enteric purinergic signaling” Role: Leader of Project 3 $1,087,500 (Project 3)

Regulatory Mechanisms in Intestinal Motility Program Project Grant P01-DK41315, 2009-2014 PI: Kenton M. Sanders Project 4: “Novel mechanisms in enteric purinergic signaling” Role: Leader of Project 4 $1,015,000 (Project 4)

Neuronal Excitability and Motility in Colitis R01-DK062267, 2013-2017 PI: Gary M. Mawe, University of Vermont Role: Sub-contractor 2013-2014 $25,000

Activation of Rho-kinase by β-NAD and ADP-ribose Mediates Increased Sympathetic Vasospasm in Genetic Hypertension 0855218F American Heart Association (AHA)-WSA Grant-in-Aid, 2008-2010 Role: PI $141,400

Neuromuscular Transmission in Arteries and Veins R01 HL-60031, 2004-2009 Role: PI $1,020,889

Release of Novel Nucleotide(s) Upon Stimulation of Postganglionic Nerve Terminals in Blood Vessels 0355118Y, American Heart Association (AHA)-WSA Grant-in-Aid, 2003-2005


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Role: PI $141,400

Differential Regulation of Nerve-evoked Adenosine 5’-diphosphoribose (ADPR) Overflow in Canine Mesenteric Artery and Vein Pre-doctoral fellowship 0215033Y PI Lisa Smyth, 2002-2004 Role: Sponsor of postdoctoral fellowship $43,430

Neuromuscular Transmission in Arteries and Veins R01 HL-60031, 1998-2003 Role: PI $1,038,234

Alcohol Consumption and Autonomic Neurovascular Control 0150755Y. AHA-WSA Grant-in-Aid, 2001-2003 Role: PI $141,400

Mechanisms of Neuromuscular Transmission in Mesenteric Artery and Vein 9706217S, AHA (Nevada Affiliate), Beginning grant-in-aid, 1997-1998 Role: PI $25,250

Peptidergic Modulation of Sympathetic Co-transmission NIH - TWO4978, NIH - Fogarty International Center Fellowship Role: PI Sponsor lab David P. Westfall, Ph.D., 1993-1995 $70,000

ORAL PRESENTATIONS AND SEMINARS

2015 Invited Speaker, Symposium on Multicellular Inputs Regulating Muscle Excitability, Granlibakken lake Tahoe, June 14-17, 2015

2013 Invited Speaker, Experimental Biology 2013, Boston, April 20-24, 2013 Multiple purinergic neurotransmitters in the abdominal viscera

2012 Invited seminar, The Molecular Biosciences Graduate Student Forum (MBGSF), University of Nevada Reno, February 7, 2012 Ceasing the ATP supremacy

2012 Invited seminar, University of Vermont, January 6-8, 2012 Ceasing the ATP supremacy

2011 ANMS Satellite meeting “Purinergic neurotransmission in gut motility”, St. Louis, MO September 14, 2011 A multiple-purine hypothesis for neural control in the colon

2011 FASEB Summer Conference, “NAD Metabolism & Signaling”, Luca, Italy, September 4-9, 2011 Regulated release and functions of NAD in excitable cells


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2009 Sierra Nevada Chapter of the Society for Neuroscience, Reno, Nevada, November 20, 2009 Emerging role of NAD as a novel neurotransmitter and neuromodulator

2008 NAD2008 Emerging roles of NAD and NAD-metabolites in cell signaling, Hamburgh-Blankenese, Germany, September 14-17, 2008 Emerging role of NAD as a novel neurotransmitter

2005 ISAN 2005, Marseille, France

CD38 contributes to the removal of extracellular -NAD+ in canine blood vessels and

in murine bladder detrusor smooth muscle

1999 Loyola University, Department of Physiology, Maywood, Illinois Sympathetic neuromuscular co-transmission and neuromodulation

1999 University of Illinois, Department of Biomedical Sciences, Rockford, Illinois Sympathetic neuromuscular co-transmission and neuromodulation

2002 Xth International Symposium on Vascular Neuroeffector Mechanisms, Granlibakken, Lake Tahoe, CA Release of novel factors upon stimulation of postganglionic nerve terminals in blood vessels

1999 East Carolina University, Department of Pharmacology, Greenville, North Carolina Sympathetic co-transmission and neuromodulation

TEACHING

2016 MED 632, Block 2, Cardiovascular, Respiratory and Kidney systems, MSI, UNSOM


2015 PCB 711, Systems Physiology for graduate students, Instructor CVS

2014 CMPP 740, Course Director, Neuroeffector Mechanisms/Neuroscience


2000-2012 PCB 611, Systems Physiology (Cardiovascular System) – instructor, course for medical students MSI, UNSOM

2005-2010 Clinical Problem Solving I, Case Hypertension and Case Coronary Artery Disease – member of faculty panel, course for medical students, UNR

2011 CMPP740, Neuroeffector pharmacology for graduate students



1994-1995 Patient Oriented Problem Solving in Pharmacology for Medical Students

1982-1987 Fundaments of Pharmacology for Medical Students Special Pharmacology for Medical Students Fundaments of Pharmacology for Pharmacy Students


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Special Pharmacology for Pharmacy Students Principles in Pharmacology for Graduate Students Principles in Pharmacology for certified pharmacists

MENTORING

2016-present Roisin McAvera, international graduate student on year placement

2015-2016 Sebstien Hayoz, Postdoctoral fellow

2015-2016 Sheerien Manzoor, international undergraduate student on year placement

2014-2015 Andrea Lees, international undergraduate student on year placement

2013-2014 Nichola Moreland, international undergraduate student on year placement

2013-2014 Robyn Higghinson, international undergraduate student on year placement

2013-present Leonie Durnin, Postdoctoral fellow

2013 Spring Sahael Hatefi, biochemistry undergraduate student

2011-2012 Keely Thornson, neuroscience undergraduate student

2011-2012 Cara Sherrill, neuroscience undergraduate student

2010 Robyn Berent, CMPP graduate student on rotation

2009-2010 Ritaben Patel, undergraduate international student on year placement

2008-2013 Leonie Durnin, PhD student

2008-2009 Leonie Durnin, CMPP graduate student on rotation

2007-2008 Imran Ali, undergraduate international student on year placement

2007-2008 Leonie Durnin , undergraduate international student on year placement

2006-2007 Rebecca Cunningham, undergraduate international student on year placement

2006 Dennis Chang, summer research medical student

2005-2007 Sergey Kamzalov, Postdoc fellow

2005-2006 Lisa Smyth, Postdoctoral fellow

2005-2006 Leonie Durnin , undergraduate international student on year placement

2004-2005 Lianne Breen, undergraduate international student on year placement

2002-2003 Roisin McAllister, undergraduate international student on year placement

2001-2002 Caitriona Byrne, undergraduate international student on year placement

2000-2005 Lisa Smyth, CMPP graduate student on rotation


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2000 Jack Zenteno, CMPP graduate student on rotation

2000-2001 Donna Gribben, undergraduate international student on year placement

1999-2001 Janet Bobalova, Postdoctoral fellow

1999-2000 Lisa Smyth, undergraduate international student on year placement

1998-1999 Bernadette Carolan, undergraduate international student on year placement

SERVICE

2014-2017 Member, Student Promotion & Conduct Committee, UNSOM

2014 Chair, Division of Health Sciences Ad-hoc Promotion & Tenure Committee

2014 Member, Search committee, Research Assistant Professor, Interstitial Cells, February-March 2013

2011-2013 Chair, Promotion and Tenure Committee, UNSOM

2013 Member, Search Committee, Assistant Professor, COBRE

2012 Member, Search Committee, Research Assistant Professor I, IKCA Channels, April-May 2012

2012 Member, Interview Committees (2), Research Assistant, Neuroscience

2011 Medical Education Curriculum reform, Phase II, UNSOM

2009-2012 Member, Faculty Council (UNSOM)

2009-present Biochemistry Graduate Program, thesis committee member

2007-2008 Medical Students Development Committee (UNSOM)

2007 Search Committee, Faculty position, Department of Physiology and Cell Biology

2003-present Member, Cell and Molecular Biology (CMB) graduate program

2007-present Member, Biochemistry graduate program

2006-2007 Review panel, PCB611 System Physiology Course for medical students

2006-2011 Judge, Graduate Student Association Outstanding Graduate Student Research Award

2005 Pre-medical student orientation

2000-2003 Member, Admission Committee, CMPP graduate program

1999-present Member, Cellular and Molecular Physiology and Pharmacology (CMPP) graduate program


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GRANT REVIEWER

2012 Research Grant Council, Hong Kong

2008 Wellcome Trust, United Kingdom

2008 National Science Foundation, USA

2007 National Science Foundation, USA

MEMBERSHIP

2016-present Society for Pelvic Research

2013-present ASPET (American Society of Pharmacology and Experimental Therapeutics)

2011-present American Neuromotilty Society

2008-present Sierra Nevada Chapter of Society for Neuroscience

2005-present American Physiological Society

2005-present American Society for Biochemistry and Molecular Biology

2004-present Society for Neuroscience

2002-present International Society for Autonomic Neuroscience

2001-present American Heart Association Basic Sciences Counsel, Council for Hypertension

2006-2011 Society for Basic Urologic Research

1994 American Association for the Advancement of Science

1994 New York Academy of Sciences

1992 Bulgarian Pharmacology Society, Board Member

JOURNAL REVIEWER

Analytical Biochemistry

Autonomic Neuroscience

British Journal of Pharmacology

BJUI, British Journal of Urology International

Cardiovascular Research

Canadian Journal of Physiology and Pharmacology

European Journal of Pharmacology


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International Journal of Neurochemistry

Gastroenterology

Journal of Anatomy

Journal of Separation Science

Journal of Pharmacology and Experimental Therapeutics

Journal of Urology

Journal of Vascular Research

Purinergic Signaling

PUBLISHED WORK

Peer-reviewed Papers

1. Durnin L, Lees A, Manzoor S, Sasse KC, Sanders KM, Mutafova-Yambolieva VN. Loss of nitric oxide-mediated inhibition of purine neurotransmitter release in the colon in the absence of interstitial cells of Cajal. Am. J. Gastrointestinal and Liver Phys. (under review)

2. Durnin L, Hayoz S, Corrigan RD, Yanez A, Koh SD, Mutafova-Yambolieva VN. Urothelial purine release during filling of murine and primate bladders. Am. J. Renal Physiol. 2016, 311(4):F708-F716

3. Durnin L, Moreland N, Lees A, V Mutafova-Yambolieva. A commonly-used ecto-ATPase inhibitor, ARL-67156, block degradation of ADP more that the degradation of ATP in murine colon. Neurogastroenterology and Motility, 2016, 28(9):1370-81.

4. Mutafova-Yambolieva VN and Sanders KM. Appropriate experimental approach is critical for identifying neurotransmitter substances: application to enteric purinergic neurotransmission. American Journal of Physiology Gastrointestinal and Liver Physiology, 309(7):G608-609, 2015

5. Durnin L, Hwang SJ, Kurahashi M, Ward SM, Sasse KC, Sanders KM, V Mutafova-Yambolieva. Uridine adenosine tetraphosphate (Up4A) is a novel neurogenic P2Y1 receptor activator in the gut. Proceedings of the National Academy of Sciences U S A 111(44):15821-6. doi: 10.1073/pnas.1409078111. Epub 2014 Oct 23, 2014.

6. Kurahashi M, Mutafova-Yambolieva V, Koh S D and K M Sanders. Platelet-derived growth

factor receptor -positive cells and not smooth muscle cells mediate purinergic hyperpolarization

in murine colonic muscles. American Journal of Physiology Cell Physiology, 307(6):C561-70. doi: 10.1152/ajpcell.00080.2014. Epub Jul 23, 2014.

7. Mutafova-Yambolieva V and L Durnin. The purinergic neurotransmitter revisited: a single substance or multiple players? Pharmacology & Therapeutics, 144(2):162-191 doi: 10.1016/j.pharmthera.2014.05.012. [Epub ahead of print] Invited Review, 2014.

8. Peri LE, Sanders KM and V Mutafova-Yambolieva. Differential expression of genes related to purinergic signaling in smooth muscle cells, PDGFRa-positive cells and interstitial cells of Cajal in the murine colon. Neurogastroenterology & Motility, 25(9):e609-20. doi: 10.1111/nmo.12174, 2013.


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9. Roberts JA, Durnin L, Sharkey KA, Mutafova-Yambolieva VN and GM Mawe. Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon. Journal of Physiology, 591(Pt 15):3725-37. doi: 10.1113/jphysiol.2013.254136, 2013.

10. Durnin L, Sanders KM, and V Mutafova-Yambolieva – Differential release of b-NAD+ and ATP upon activation of enteric motor neurons in primate and murine colons. Neurogastroenterology & Motility, 25(3):e194-204. doi: 10.1111/nmo.12069, 2013.

• Highlight: Smith K. Neurogastroenterology: Colonic motor neurotransmission-is -NAD+ in

control? Nat Rev Gastroenterol Hepatol 10(2):64, 2013.

11. Mutafova-Yambolieva V – Neuronal and extraneuronal release of ATP and NAD+ in smooth muscle. IUBMB Life 64(10):817-824. doi: 10.1002/iub.1076. Epub 2012 Sep 3, 2012.

12. Hwang SJ, Blair PJ, Durnin L, Mutafova-Yambolieva V, Sanders KM and SM Ward - P2Y1 purinoreceptors are fundamental to inhibitory motor control of murine colonic excitability and transit. Journal of Physiology 590(Pt 8):1957-72. doi: 10.1113/jphysiol.2011.224634. Epub 2012 Feb 27, 2012.

• Comment: King BF. Resolution and concordance in dissecting the compound inhibitory junction potential. J Physiol 590(Pt8): 1777-8, 2012.

13. Durnin L, Hwang SJ, Ward SM, Sanders KM and VN Mutafova-Yambolieva - Adenosine 5’-diphosphate-ribose (ADPR) is a neural regulator in primate and murine large intestine along with β-NAD+. Journal of Physiology 590(Pt 8):1921-41. doi: 10.1113/jphysiol.2011.222414. Epub 2012 Feb 20, 2012.

14. Durnin L, Dai YP, Aiba I, CW Shuttleworth, Yamboliev IA, VN Mutafova-Yambolieva - Release, neuronal effects and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. European Journal of Neuroscience. 35(3):423-35. doi: 10.1111/j.1460-9568.2011.07957.x. Epub 2012 Jan 25, 2012.

15. Mutafova-Yambolieva VN, Sanders KM, Hwang SJ. Reply. Gastroenterology, 2011; 141(4): e27; author reply e27-8. PMID: 21888906

16. Durnin L, VN Mutafova-Yambolieva - Cyclic ADP-ribose (cADPR) requires CD38 to regulate the release of adenosine 5’-triphosphate (ATP) in visceral smooth muscle, FEBS Journal, 278(17):3095-108. Doi:10.1111/j.1742-4658.2011.08233.x.Epub 2011 Aug 8, 2011.

17. Hwang SJ, Durnin L, Dwyer L, Rhee PL, Ward SM, Koh SD, Sanders KM, and VN Mutafova-Yambolieva - ß-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons. Gastroenterology, 140(2):608-617.e6 Epub 2010 Sep 25, 2011.

• Comment: Rodriguez-Tapia E, Galligan JJ. A new player in neuromuscular transmission in the gastrointestinal tract. Gastroenterology. 140(2):397-400, 2011.

• Comment: Goyal R, Evidence for -nicotinamide adenine dinucleotide as a purinergic,

inhibitory neurotransmitter in doubt. Gastroenterology. 141(4);e27, 2011.

18. Yamboliev IA, Smyth LM, Durnin L, Dai Y-P, VN Mutafova-Yambolieva - Storage and secretion of β-NAD, ATP and dopamine in NGF-differentiated rat pheochromocytoma PC12 cells. European Journal of Neuroscience, 30:756-768, 2009.


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19. Smyth LM, Yamboliev IA, VN Mutafova-Yambolieva. N-type and P/Q-type calcium channels regulate differentially the release of noradrenaline, ATP and β-NAD in blood vessels. Neuropharmacology, 56(2):368-378, 2009.

20. Dai Y-P, Bongalon S, Mutafova-Yambolieva V, Yamboliev IA. Distinct effects of contraction agonists on the phosphorylation state of cofilin in pulmonary artery smooth muscle, Advances in Pharmacological Sciences, Vol. 2008, ID 362741, 2008.

21. Mutafova-Yambolieva VN, Hwang SJ, Hap X, Chen H, Zhu MX, Wood JD, Ward SM, Sanders KM - ß-nicotinamide adenine dinucleotide is a new inhibitory neurotransmitter in visceral smooth muscle. Proceedings National Academy of Sciences USA, 104(41):16359-64, 2007.

22. Bobalova J, VN Mutafova-Yambolieva - Activation of the adenylyl cyclase-protein kinase A pathway facilitates neural release of β-nicotinamide adenine dinucleotide (β-NAD) in canine mesenteric artery. European Journal of Pharmacology, 536, 128-132, 2006.

23. Smyth LM, Breen LT, Yamboliev IA, VN Mutafova-Yambolieva - Novel localization of CD38 in perivascular sympathetic nerve terminals. Neuroscience, 139 (4): 1467-1477, 2006.

24. Smyth LM, Breen LT, VN Mutafova-Yambolieva - Nicotinamide adenine dinucleotide (NAD) is released from sympathetic nerve terminals via a botulinum neurotoxin A mediated mechanism in canine mesenteric artery. Am J Physiol Heart and Circ Physiol. 290(5), H1818-H1825, 2006.

25. Dai Y-P, Bongalon S, Tian H, Mutafova-Yambolieva V, IA Yamboliev - Upregulation of profilin, cofilin-2 and LIMK2 in cultured pulmonary artery smooth muscle cells and in pulmonary arteries of monocrotaline-treated rats. Vascular Pharmacol. 44(5), 275-282, 2006.

26. Breen LT, Smyth LM, Yamboliev IA, VN Mutafova-Yambolieva - beta-NAD is a novel nucleotide released upon stimulation of nerve terminals in human urinary bladder detrusor muscle. Am J Physiol Renal Physiol. 290(2), F486-F495, 2006.

27. Yamboliev IA, VN Mutafova-Yambolieva - PI3K and PKC contribute to membrane depolarization mediated by alpha2-adrenoceptors in the canine isolated mesenteric vein. BMC Physiol. 15, 5:9, 2005.

28. Smyth LM, Bobalova J, Mendoza MG, Lew C, VN Mutafova-Yambolieva - Release of beta-nicotinamide adenine dinucleotide upon stimulation of postganglionic nerve terminals in blood vessels and urinary bladder. J Biol Chem. 279(47), 48893-48903, 2004.

29. Baker SA, Mutafova-Yambolieva VN, Monaghan K, Sanders KM, SD Koh - Mechanism of active repolarization of inhibitory junction potential in murine colon. Am J Physiol Gastrointest Liver Physiol. 285(5), G813-21, 2003.

30. Mutafova-Yambolieva VN, O’Driscoll K, Farrelly, A, Ward, S, Keef, KD. Spatial localization and properties of pacemaker potentials in the canine rectoanal region. Am J Physiol Gastrointest Liver Physiol., 284(5), G748-55, 2003.

31. Bobalova J, V N Mutafova-Yambolieva – Membrane-bound and releasable nucleotidase activities: differences in canine mesenteric artery and vein. Clinical and Experimental Physiology and Pharmacology, 30(3):194-202, 2003.

32. Mutafova-Yambolieva V, Smyth L, J Bobalova– Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein. Cardiovascular Research, 57/1, 217-224, 2003.


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33. Yamboliev IA, Ward S M, V Mutafova-Yambolieva - Canine mesenteric artery and vein convey no difference in the content of major contractile proteins. BMC Physiology, 2, 17, 2002.

34. Bobalova J, Bobal P, V Mutafova-Yambolieva - High-performance liquid chromatographic technique for detection of a fluorescent analogue of ADP-ribose in isolated blood vessel preparations. Analytical Biochemistry 305, 269-276, 2002.

35. Bobalova J, V N Mutafova-Yambolieva - Presynaptic 2-adrenoceptor mediated modulation of ATP and noradrenaline co-release: differences in canine mesenteric artery and vein J Autonomic Pharmacol, 21, 1-9, 2001.

36. Bobalova J, V N Mutafova-Yambolieva – Corelease of endogenous ATP and NA in guinea-pig vein exceeds corelease in mesenteric artery. Clin Exp Pharmacol Physiol 28, 397-401, 2001.

37. Mutafova-Yambolieva V N, K D Keef – Frequency dependent 2-adrenoceptor mediated

modulation of excitatory junction potentials in guinea-pig mesenteric artery. Eur. J. Pharmacology, 411/1-2, 125-129, 2001.

38. Smyth L, J Bobalova, S M Ward and V N Mutafova-Yambolieva - Neuropeptide Y is a cotransmitter with noradrenaline in guinea-pig inferior mesenteric vein: immunohistochemistry and vasomotility. Peptides, 21(6), 835-843, 2000.

39. Smyth L, J Bobalova, S M Ward, K D Keef, V N Mutafova-Yambolieva - Cotransmission from sympathetic vasoconstrictor neurons: differences in guinea-pig mesenteric artery and vein. Autonomic Neuroscience: Basic and Clinical, 86/1-2, 18-29, 2000.

40. Mutafova-Yambolieva V, B M Carolan, T K Harden and K D Keef - P2Y Receptors Mediate Contraction in Guinea-Pig Mesenteric Vein. Gen Pharm The Vascular System 34, 2000, 127-136

41. Mutafova-Yambolieva V and D P Westfall - Effects of type-C Natriuretic Peptide (CNP) on Adrenergic/Purinergic Cotransmission in Rat Tail Artery. Clin Exp Pharmacol Physiol., 25, 12, 1013-1018, 1998.

42. Mutafova-Yambolieva V and D P Westfall - Inhibitory and Facilitatory Presynaptic Effects of Endothelin on Sympathetic Cotransmission in the Rat Isolated Tail Artery. Br J Pharmacol, 123, 136-142, 1998.

43. Mutafova-Yambolieva V N and K D Keef - Adenosine-induced hyperpolarization in guinea-pig coronary artery involves A2b receptors and KATP channels. Am J Physiol (Heart & Circulation 42), 273, H2687-H2695, 1997.

44. Mutafova-Yambolieva V, I A Yamboliev, W T Gerthoffer and D P Westfall - Effect of Natriuretic Peptides and Endothelins on Nerve-Evoked Release of Adenine Nucleotides and Nucleosides in Guinea-Pig Vas Deferens. Can J Physiol Pharmacol 75, 1997, 1083-1087.

45. Mutafova-Yambolieva V and D P Westfall - Modulatory effects of endothelin-3 on release of the sympathetic nerve cotransmitters noradrenaline and ATP. Eur J Pharmacol 285, 213-216, 1995.

46. Mutafova-Yambolieva V and R Radomirov - Modulatory effects of endothelin-1 on purinergic and adrenergic components of sympathetically-mediated contractile activity of rabbit saphenous artery. Br. J. Pharmacol 112, 1109-1117, 1994.

47. Yamboliev I, V Mutafova-Yambolieva and D Mihailova - Galanthamine and rat gastro-intestinal tract in situ and in vitro. Eur. J Drug Metab Pharmacokin , 1994.


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48. Mutafova-Yambolieva V, D Staneva-Stoytcheva, L Lasova and R Radomirov - Effects of cobalt or nickel on the sympathetically mediated contractile responses in rat isolated vas deferens. Pharmacology 48, 2, 100-110, 1994.

49. Mutafova-Yambolieva V, D Staneva-Stoytcheva, L Lasova and R Radomirov - Effects of subchronic exposure of rats to lead or zinc on alpha-adrenoceptor mediated contractile responses in isolated vas deferens. Acta Physiol Pharmacol Bulg 19, 4, 111-119, 1993.

50. Yamboliev I, V Mutafova-Yambolieva and D Mihailova - Gastro-intestinal loss of galanthamine hydrobromide in rats in situ. J Pharm Pharmacol 45, 763-765, 1993.

51. Mutafova-Yambolieva V, I Yamboliev and D Mihailova - Comparative effects of the anticholinesterase drug galantamine on the mechanical activity of isolated rat jejunum and ileum. Gen Pharmacol 24, 1253-1256, 1993.

52. Mutafova-Yambolieva V, K Venkova and L Lasova - Atrial natriuretic peptide (ANP) inhibits purinergic but not adrenergic component of electrically-induced mechanical responses in guinea-pig vas deferens. J Pharmacol Exptl Ther 265, 2, 920-926, 1993.

53. Mutafova-Yambolieva V and R Radomirov - Effects of endothelin-1 on postjunctionally-mediated purinergic and adrenergic components of rat vas deferens contractile responses. Neuropeptides 24, 35-42, 1993.

54. Radomirov R and V Mutafova-Yambolieva - Effect of endothelin-1 on the tone of electrically-stimulated rat vas deferens. Arch Int Pharmacodyn 318, 86-96, 1992.

55. Mutafova-Yambolieva V, O Petkov, D Staneva-Stoytcheva and L Lasova - Interactions between the effect of endothelin-1, clonidine and yohimbine on electrically-induced contractions in rat vas deferens. Gen Pharmacol 23, 3, 529-534, 1992.

56. Vassilev P, D Staneva-Stoytcheva and V Mutafova-Yambolieva - Do H3 -receptors participate

in the effects of histamine on electricalli-evoked contractions of rat vas deferens? Gen Pharmacol 22, 4, 643-645, 1991.

57. Vassilev P, V Mutafova-Yambolieva, D Staneva-Stoytcheva and S. Todorov - Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs. Gen Pharmacol 22, 4, 699-702, 1991.

58. Staneva-Stoytcheva D, J Popova and V Mutafova-Yambolieva - Cholinergic and adrenergic receptor modulation by long-term administration of calcium and calmodulin antagonists. Eur J Pharmacol, 183, 587-588, 1990.

59. Popova J, D Staneva-Stoytcheva and V Mutafova-Yambolieva - Effects of the Ca2+-antagonists nifedipine, verapamil, flunarizine and of the calmodulin antagonist trifluoperazine on muscarinic cholinergic receptors in rat cerebral cortex. Gen Pharmacol 21, 3, 317-319, 1990.

60. Staneva-Stoytcheva D, J Popova, V Mutafova-Yambolieva and P Alov - Influence of long-term treatment with the Ca2+-antagonists nifedipine, verapamil, flunarizine and with the calmodulin antagonist trifluoperazine on beta-receptors in rat cerebral cortex. Gen Pharmacol 21, 1, 149-152, 1990.

61. Mutafova-Yambolieva V, D Staneva-Stoytcheva and R Nikolov - Comparative evaluation of the Ca2+-antagonistic activity of some Bulgarian vasodilating agents and known Ca2+ antagonists on


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K+-depolarized smooth muscle from guinea-pig taenia coli. Acta Physiol Pharmacol Bulg 5, 2, 40-46, 1989.

62. Mutafova-Yambolieva V and D Staneva-Stoytcheva - Pharmacodynamic effects of a 2-piperazinotetralin (P-11) - combined alpha- and beta-adrenoceptor blocking drug with hypotensive action. Meth Find Exptl Clin Pharmacol 10, 9, 551-557, 1988.

63. Mutafova-Yambolieva V and D Staneva-Stoytcheva - Involvement of peripheral dopaminergic mechanisms in the action of a 2-piperazinotetralin (P-11) with hypotensive activity. Meth Find Exptl Clin Pharmacol 10, 9, 559-562, 1988.

64. Mutafova-Yambolieva V and D Staneva-Stoytcheva - Peripheral origin of the hypotensive action of a piperazinotetralin derivative P-11. Compte Rend Acad Bulg Sci 41, 4, 81-83, 1988.

65. Mutafova-Yambolieva V, D Staneva-Stoytcheva and D Ivanov - Effects of a new 2-aminotetralin on the alpha-1 and alpha-2 adrenergic receptors on isolated rat vas deferens. Meth Find Exptl Clin Pharmacol 7, 6, 291-296, 1985.

66. Mutafova-Yambolieva V and D. Staneva-Stoytcheva - Effect of one derivative of 2-aminoteralin on the alpha-adrenergic receptors of isolated vessels. Acta Physiol Pharmacol Bulg 11, 1985, 1, 18-25.

67. Mutafova-Yambolieva V and D Staneva-Stoytcheva - Adrenergic mechanisms of action of a piperazine derivative of 2-aminotetralin. Exp Med Morfol, 24, 1, 8-12, 1985 (in Bulgarian).

68. Staneva-Stoytcheva D, L Raynova, L Tchakarova, V Mutafova, D Ivanov, M Micheva and L Tancheva - Studies on the cardiovascular effects and toxicity of anti-menier drug Betahistine. Probl. Farmazie 13, 63-77, 1985 (in Bulgarian).

69. Vlahov V and V Mutafova - Nivalin and pymadin. Effect of the preparations on cerebral circulation. Medico-Biological Information, 2, 10-12, 1979.

70. Vlahov V, S M Dimitrova and V N Mutafova - Influence of the compound AC-2 on the cerebral circulation and on the oxygen consumption of the brain. Compte Rend Acad Bulg Sci 31, 7, 933-935, 1978.

Book Chapters

1. Eckman DM, V Mutafova, N Hopkins, C McBride and K D Keef - Endothelium-dependent relaxation and hyperpolarization in the guinea-pig coronary artery: role of epoxyeicosatrienoic acid. Endothelium-derived hyperpolarizing factor, Ed. P.M.Vanhoutte ipd International Publishers Distributor, 1999.

2. Mutafova-Yambolieva V and D Staneva-Stoytcheva - Peripheral cardiovascular dopaminegic receptors - physiological and pharmacological role. In "Trends in Pharmacology and Pharmacotherapy", Medicina i Fizkultura, Sofia, 63-82, 1989 (in Bulg).

3. Mutafova V - Calcium antagonist in the treatment of cerebrovascular disorders. In "Calcium Antagonists - Pharmacology and Clinical Use", ed by D. Staneva-Stoytcheva, CNIMZ, Sofia, 49-51, 1984 (in Bulg).

4. Mutafova V - Pharmacological modulation of calcium movements. Conception of calcium antagonists. In "Calcium Antagonists -Pharmacology and Clinical Use", ed. by D. Staneva-Stoytcheva, CNIMZ, Sofia, 23-30, 1984 (in Bulg).


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5. Mutafova V - Role of calcium ions on the functions of the smooth muscles, heart muscle and skeletal muscles. In "Calcium Antagonists -Pharmacology and Clinical Use", ed. by D. Staneva-Stoytcheva, CNIMZ, Sofia, 16-19, 1984 (in Bulg).

6. Mutafova V - Mechanisms of intracellular calcium dynamics. In "Calcium Antagonists - Pharmacology and Clinical use", ed. by D. Staneva-Stoytcheva, CNIMZ, Sofia, 5-10, 1984 (in Bulg).

7. Mutafova V and D Staneva-Stoytcheva - Pharmacological role of calcium ions. Calcium antagonists. Exp. Med. Morf. 4: 1-9, 1983.

Abstracts

1. Durnin L, Lees A, Manzoor S, Sasse KC, Sanders KM, and VN Mutafova-Yambolieva. Loss of nitric oxide-mediated inhibition of purine neurotransmitter release in the colon in the absence of interstitial cells of Cajal. The 1st Annual Meeting, Society for Pelvic Research, Charleston, SC, December 5-6, 2016. AB274. SPR-01, vol 5, Supplement 2 (December 2016): Translational Andrology and Urology.

2. VN Mutafova-Yambolieva and Durnin L. Mechanosensitive release of ATP and other purines from the bladder urothelium. The 1st Annual Meeting, Society for Pelvic Research, Charleston, SC, December 5-6, 2016. AB274. SPR-01, vol 5, Supplement 2 (December 2016): Translational Andrology and Urology. AN309. SPR-36, vol 5, Supplement 2 (December 2016): Translational Andrology and Urology.

3. Durnin L and VN Mutafova-Yambolieva. Changes in stretch-induced purine release from bladder mucosa may contribute to underactive bladder in aging. 2nd International Congress CURE-UAB, Denver, CO, December 3-4, 2015.

4. Mutafova-Yambolieva V. The purine alliance in abdominal viscera. Symposium on Multicellular Inputs Regulating Muscle Excitability. Granlibakken Tahoe, Tahoe City, CA June 14-17, 2015.

5. Lees A, Durnin L, V. Mutafova-Yambolieva. Nitric oxide modulates the release of purine neurotransmitters in the murine large intestine. Symposium on Multicellular Inputs Regulating Muscle Excitability. Granlibakken Tahoe, Tahoe City, CA, June 14-17, 2015.

6. Mutafova-Yambolieva V, L Durnin. Neurogenic purines in colons from human and non-human primates. Purines 2014, Bonn, Germany, July 22-27, 2014.

7. Durnin L, Mutafova-Yambolieva V. Differential degradation of NAD+ and ATP by smooth muscle

cells (SMC), interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor -positive

(PDGFR +) cells in colon. ANMS 2013, Huntington Beach, CA, USA, September 20-22, 2013.

8. Mutafova-Yambolieva V. Multiple purinergic neurotransmitters in the abdominal viscera, Experimental Biology 2013, Boston, MA, April 20-24, 2013.

9. Roberts JA, L Durnin, KA Sharkey, V N Mutafova-Yambolieva, G M Mawe. Free radical scavengers rescue decreased purinergic neuromuscular transmission in the inflamed colon. NGM 2012, Bologna, Italy, September 6-8, 2012.

10. Mutafova-Yambolieva V, L Durnin, K M Sanders. Release of β-NAD and ATP upon activation of myenteric 5-HT3 or nicotinic acetylcholine receptors in murine and primate colons. NGM 2012, Bologna, Italy, September 6-8, 2012.


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11. Hwang SJ, V N Mutafova-Yambolieva, K M Sanders, S M Ward. -NAD and/or its metabolite, ADP-ribose, may mediate purinergic post-junctional enteric inhibitory responses in the colon. 16th Neurogastroenterology & Motility Meeting, St. Louis, MO, USA September 16-18, 2011, Abstract 89.

12. Durnin L, S J Hwang, S M Ward, K M Sanders, V N Mutafova-Yambolieva. β-NAD and ADP-ribose are neural regulators in primate and murine large intestine. Neurogastroenterology & Motility Meeting, St. Louis, MO, USA September 16-18, 2011 Oral presentation, Abstract 31.

13. Roberts JS, L Durnin, VN Mutafova-Yambolieva, KA Sharkey, GM Mawe. Mechanism of disrupted purinergic neuromuscular transmission in the inflamed colon. 16th Neurogastroenterology & Motility Meeting, St. Louis, MO, USA September 16-18, 2011, Abstract 28.

14. Mutafova-Yambolieva VN. Regulated release of NAD in excitable cells. Invited speaker. FASEB Summer Research Conference “NAD Metabolism and Signaling”, Lucca, Italy September 4-9, 2011.

15. Hwang S, VN Mutafova-Yambolieva, KM Sanders, and SM Ward, β-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in the monkey proximal colon. Neurogastroenterology and Motility 2009 International Meeting, Chicago, IL, USA August 27-30, 2009. Abstract 154.

16. Mutafova-Yambolieva VN, IA Yamboliev, KM Sanders, SM Ward, D. Redelman. Emerging role of NAD as a novel neurotransmitter. Invited speaker. NAD2008 Emerging roles of NAD and NAD-metabolites in cell signaling, Hamburgh-Blankenese, Germany, September 14-17, 2008.

17. Mutafova-Yambolieva V N, LM Smyth, LT Breen, L Durnin, I A Yamboliev, β-NAD and CD38 provide a novel mechanism of autonomic nervous system control of vascular and visceral smooth muscle. Abstract selected for oral presentation. ISAN 2007, 5th International Congress of the International Society for Autonomic Neuroscience, Kyoto, Japan, 5-8 October, 2007.

18. Hiragata S, MB Chancellor, WC de Groat, V N Mutafova-Yambolieva, N Yoshimura, Effect of ß-nicotinamide adenine dinucleotide (ß-NAD) on in vivo bladder function in mice. American Urology Association, AUA2007 Annual meeting, Anaheim, CA, May 19-24, 2007.

19. Mutafova-Yambolieva V N, L M Smyth, L T Breen, I A Yamboliev - CD38 is present in

peripheral nerve terminals and contributes to the removal of neurally released extracellular -

NAD+ in mesenteric blood vessels and urinary bladder. Poster presentation with recognition. “The CD38 Enzyme Family: Advances in basic Science and Clinical Practice”, Torino, Italy, June 8-10, 2006. Abstract published in Molecular Medicine, 12 (Suppl 1), S17, 2006.

20. Yamboliev I A, Yan-Ping Dai and V N Mutafova-Yambolieva - Cofilin inactivation is required for maximal contraction of pulmonary artery. ISAN 2005, 4th International Congress of the International Society for Autonomic Neuroscience, Marseille, France, 12-16 July, 2005.

21. Smyth L M, L T Breen, M G Mendoza, R McAllister, I A Yamboliev, V N Mutafova-Yambolieva -

CD38 contributes to the removal of extracellular -NAD+ in canine blood vessels and in murine

bladder detrusor smooth muscle. Abstract selected for oral presentation. ISAN 2005, 4th International Congress of the International Society for Autonomic Neuroscience, Marseille, France, 12-16 July, 2005.


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22. Smyth LM, M G Mendoza, V N Mutafova-Yambolieva - Release of novel nucleotide factors upon nerve stimulation in urinary bladder. Urothelial Cell Physiology in Normal and Disease States, Urothelium 2005, UIPS 2005 Satellite Symposium, San Diego, CA, March 29-30, 2005.

23. Smyth L.M., M. G. Mendoza, V. N. Mutafova-Yambolieva - Release of nicotinamide dinucleotide (NAD), cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from postganglionic nerve terminals. Neuroscience 2004, 34th Annual Meeting, San Diego, CA, October 23-27, 2004.

24. Mutafova-Yambolieva V, L M Smyth, C Lew, J Bobalova, I A Yamboliev – Release of novel nucleotide(s) upon stimulation of perivascular nerve terminals. ISAN 2003, Calgary, Alberta, Canada, July 4-9, 2003.

25. Mutafova-Yambolieva V – Release of novel factors upon stimulation of sympathetic neurons in blood vessels. Invited presentation. Xth International Symposium on Vascular Neuroeffector Mechanisms, Granlibakken, Lake Tahoe, CA, July 12-15, 2002.

26. Smyth L, J Bobalova, C Lew, V N Mutafova-Yambolieva – Release of ADP-ribose upon stimulation of sympathetic nerves in canine isolated mesenteric artery. Xth International Symposium on Vascular Neuroeffector Mechanisms, Granlibakken, Lake Tahoe, CA, July 12-15, 2002.

27. Mutafova-Yambolieva V, J Bobalova, S M Ward, K D Keef, L Smyth – Comparison of autonomic neurotransmission in guinea-pig mesenteric artery and vein. Experimental Biology 2000, April 15-18, 2000, FASEB Journal, 2000.

28. Mutafova-Yambolieva V, S M Ward, and K D Keef – Spatial localization of pacemaker potentials and ICC in the canine rectoanal region. Digestive Disease Week, Orlando, Florida, May 16-19, 1999. Gastroenterology, 116(4), part 2, G4549, DDW Poster of Distinction, 1999.

29. Mutafova-Yambolieva V, B M Carolan, and K D Keef - Effects of exogenous adenine and uridine nucleotides on the tone of guinea-pig mesenteric artery and vein. Experimental Biology 98TM, San Francisco, California, April 18-22, 1998. FASEB Journal, 12, 5, Part II, p. A706, 1998.

30. Mutafova-Yambolieva V and K D Keef - Adenosine-induced hyperpolarization in guinea-pig coronary artery involves A2b receptors and KATP channels. Abstract selected for oral presentation. 7th Symposium on Mechanisms of Vasodilatation, Maastricht, The Netherlands, July 6-9, 1997. J. Vascular Research, vol. 34, suppl. 1, p.30, 1997.

31. Mutafova-Yambolieva V and D P Westfall - Effects of natriuretic peptides on electrically evoked release of norepinephrine and adenyl compounds in guinea pig vas deferens. Experimental Biology 95TM, Atlanta, Georgia, April 9-13, 1995. FASEB Journal, 9, 3, p. A91, 1995.

32. Yamboliev I, V Mutafova-Yambolieva and D Mihailova - Galanthamine and rat G.I.T. in situ and in vitro. Fifth European Congress of Biopharmaceutics and Pharmacokinetics. Brussels, April 20-22, 1993, Abstract published in Eur J Drug Metabolism and Pharmacokinetics 18, 1, p. 1, 1993.

33. Staneva-Stoytcheva D and V Mutafova-Yambolieva - Calcium antagonistic activity of piracetam and flunarizin in K+-depolarizied smooth muscle of guinea-pig taenia coli. Second National Congress of Pharmacy, Sofia, October 8-10, Abstracts 177, 1992.

34. Yamboliev I, V Mutafova-Yambolieva and D Mihailova - Gastrointestinal resorbtion of galanthamine: rate and mechanisms in situ and in vitro. Second National Congress of Pharmacy, Sofia, October 8-10, Abstracts 199, 1992.


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35. Mutafova-Yambolieva V, D Staneva-Stoytcheva, L Lasova - Changes in adrenergic neurotransmission of rat vas deferens during subchronic intoxication with heavy metals (Co2+, Ni2+, Pb2+, Zn2+). Second National Congress of Pharmacy, Sofia, October 8-10, Abstracts 253, 1992.

36. Mutafova-Yambolieva V, R Radomirov, K Venkova, L Lasova and D Staneva-Stoytcheva - Modulatory effects of endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) on sympathetic cotransmission in rat and guinea-pig vas deferens. Workshop "Neuropeptides and cardiovascular functions", Regional European Neuropeptide Club Meeting, Sofia, September 18-20, Abstract 32, 1992.

37. Staneva-Stoytcheva D, J Popova and V Mutafova-Yambolieva - Cholinergic and adrenergic receptor modulation by long-term administration of calcium and calmodulin antagonists. XI International Congress of Pharmacology, Amsterdam, July 1-6, 1990.

38. Vassilev P, D Staneva-Stoytcheva, V Mutafova-Yambolieva - Do H3-receptors participate in the

effects of histamine on electrically-evoked contractions of rat vas deferens? XIth International Congress of Pharmacology, Amsterdam, July 1-6, 1990.

39. Popova J, D Staneva-Stoytcheva and V Mutafova - beta-adrenergic receptor activity change after long-term treatment of rats with Ca2+-antagonists nifedipine, verapamil, flunarizine and with the calmodulin antagonist trifluoperazine. Third International Symposium "Pharmacology of Transmitter Interactions", Sofia, May 16-17, Abstracts p.70, 1990.

40. Popova J, D Staneva-Stoytcheva and V Mutafova - The Ca2+-antagonists nifedipine, varapamil, flunarizine and the calmodulin antagonist trifluoperazine differentially change the activity of rat cortical muscarinic receptors. Third International Symposium "Pharmacology of Transmitter Interactions", Sofia, May 16-17, Abstracts p.69, 1990.

41. Vassilev P, V Mutafova, D Staneva, S Todorov - Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs. Third International Symposium "Pharmacology of Transmitter Interactions", Sofia, May 16-17, Abstracts p.92, 1990.

42. Staneva D, J Popova, V Mutafova, P Popov and N Danchev - Receptor modulation by long-term administration of different calcium and calmodulin antagonists in rats. Third National Congress of the Bulgarian Pharmacological Society, Sofia, May 17-20, Abstracts p. 263, 1990.

43. Yonkov D, D Markovska, D Staneva and V Mutafova - The influence of nifedipine on memory and learning and on nootropic effects of citicholine. Third National Congress of the Bulgarian Pharmacological Society, Sofia, May 17-20, Abstracts p. 318, 1990.

44. Vassilev P, D Staneva and V Mutafova - Do H3-receptors participate in the effects of histamine in the rat vas deferens. Third National Congress of the Bulgarian Pharmacological Society, Sofia, May 17-20, Abstracts p.300, 1990.

45. Vassilev P, V Mutafova and D Staneva - Role of the calcium ion in the mechanism of action of histaminergic agents on electrically evoked muscle responses of rat vas deferens. Conference of Young Scientists of Volgograd Institute, Volgograd, December 1989, Abstracts 19, 1989.

46. Vassilev P., D. Staneva and V. Mutafova - Involvement of calcium ions in the modulation of rat vas deferens contractions by histaminergic drugs. 18th Meeting of the European Histamine Research Society, Breda, May 17-20, 1989, Abstracts p. 104, 1989.


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47. Mutafova-Yambolieva V and D Markovska - Ca2+-dependence of carbachol contractile effects in smooth muscle of guinea-pig taenia coli. 5th International symposium "Physiology and Pharmacology of the Smooth Muscle", October 1988, Varna, Abstracts p.90, 1988.

48. Mutafova V, D Staneva-Stoytcheva and R Nikolov - Calcium antagonistic activity of Bulgarian vasodilator agents on K+-depolarizied smooth muscle. Seventh National Conference of Pharmacology and Clinics of Bulgarian Medicines. April 1988, Sofia, Abstracts 16, 1988.

49. Mutafova V and D Staneva-Stoytcheva - On alpha-adrenolytic properties in isolated blood vessels of one derivative of 2-aminotetraline with hypotensive activity. Jubilee Scientific Session "Biology and Pathology of Cardiovascular System", December 1984, Sofia, Abstracts p. 64, 1984.

50. Staneva-Stoytcheva D, L Tancheva, V Mutafova, M Micheva, L Raynova, L Tchakarova and D Ivanov - Pharmacological and Toxicological studies on Betahistin. Second National Congress of Pharmacology, Plovdiv, May 1984, Abstracts 346, 1984.

51. Mutafova V, D Ivanov and D Staneva - Pre- and postsynaptic mechanisms of the action of one piperazine derivative of 2-aminotetraline. Second National Congress of Pharmacology, Plovdiv, May 1984, Abstracts 136, 1984.

52. Mutafova V - Experimental studies on cardiovascular effects of one piperazine derivative of 2-aminotetraline. Scientific Session "Actual Problems of the Public Health", Sofia, May 1983, Abstracts p. 63, 1983.

53. Vlahov V, S. Dimitrova, D Zafirov and V Mutafova - Effects of cinnarizine, aligeron and piracetam on cerebral blood flow and cerebral arterio-venous differences in partial pressure of O2 (pO2), CO2 (pCO2) and pH. First National Congress of Pharmacology, October 1978, Sofia, Abstracts 22/1, 1978.

54. Mutafova V - Importance of the pharmacologically evoked temperature changes in the brain during measurement of the cerebral blood flow by means of thermoclearance technique. Jubilee Medical Scientific Session, March 1978, Sofia, Abstracts 46.

55. Vlahov V, S Dimitrova and Mutafova V - Effect of the Bulgarian cinnarizine analog AC-2 on cerebral blood flow and oxygen consumption of the brain. First Scientific Session of the Institute of Internal medicine and Pharmacology, Nov 1977, Sofia, Abstracts p. 10, 1977.

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