1

Covered in Last Lecture

✓ Innate System

4 Properties of Acquired System:1. Diversity2. Specificity3. Self vs non-Self4. Memory

✓

(blue)(red)

Covered in Last Lecture

✓ Innate System

4 Properties of Acquired System:1. Diversity2. Specificity3. Self vs non-Self4. Memory

Antibody Structure: 2 Heavy chains 2 Light chains

✓

✓

2

Covered in Last Lecture

✓ Innate System

4 Properties of Acquired System:1. Diversity2. Specificity3. Self vs non-Self4. Memory

Antibody Structure: 2 Heavy chains 2 Light chains

Generating Diversity - V(D)J recombination DNA re-arrangements of Heavy Chain Gene

✓

✓

✓

Covered in Last Lecture

✓ Innate System

4 Properties of Acquired System:1. Diversity2. Specificity3. Self vs non-Self4. Memory

Antibody Structure: 2 Heavy chains 2 Light chains

Generating Diversity - V(D)J recombination DNA re-arrangements of Heavy Chain Gene

- similar process for Light Chain Gene- similar process for genes that encode for the T Cell Receptor

✓

✓

✓

19.14

Figure 19.14

T Cell Receptor - TCR

3

Outline of the Human Immune System

Pathogen

Innate Acquired

specificnon-specific

Humoral(foreigners)

Cellular(body cells gone bad)

skin proteins(lysozyme)

small molecules(H2O2)

B Cells TH Cells Tc Cells

Antibodies T Cell Receptors

macrophages

How would you engineer a systemto fight invaders?

Would need:

Cells to recognize invader-need to recognize specifically-must not recognize self

Cells to destroy invader-must have many of these

Memory

Common Abbreviations

TH = T Helper Cell

TC = T Cytotoxic Cell

Ab = Antibody

Ag = Antigen

TCR = T Cell Receptor

MHC = Major Histocompatibility Complex

Structure of MHC* I & II

I II* = Major Histocompatability Complex

4