chromosomal chiasmataweb.mit.edu/7.01x/7.013/documents/geneticslecture3.pdf · 2007. 2. 26. · 1...
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STARTSTARTFOUNDATIONSFOUNDATIONS
How-to 1How-to 1 FO
RM
AT
ION
FO
RM
AT
ION
How-to 2How-to 2
SYSTEMSSYSTEMSPR
OB
LE
MS
PR
OB
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MS
Future ofFuture of
BIOCHEM GENETICS CELL BIO.MOL. BIO
STEM
CELLS,
CLONING
REC. DNA
CELL
TYPE
3DSTRUCTURE
FERTILI-
ZATION
SYSTEMS
VIRUSES
IMMUNE
LIFELIFE
NERVOUSCANCER
2
STARTSTARTFOUNDATIONSFOUNDATIONS
How-to 1How-to 1 FO
RM
AT
ION
FO
RM
AT
ION
How-to 2How-to 2
SYSTEMSSYSTEMSPR
OB
LE
MS
PR
OB
LE
MS
Future ofFuture of
BIOCHEM GENETICS CELL BIO.MOL. BIO
STEM
CELLS,
CLONING
REC. DNA
CELL
TYPE
3DSTRUCTURE
FERTILI-
ZATION
PRIONS
VIRUSES
CANCER
LIFELIFE
IMMUNE NERVOUS
BIOCHEM GENETICS
3
Student question of the day
Q: What makes an allele recessive?
A: Alleles in isolation are not dominant or
recessive; phenotypes are dominant or
recessive.
Alleles contribute to “pea shape”:
Genotype Phenotype Dominance
SS smooth smooth >
Ss smooth wrinkled
ss wrinkled4
http://www.humanillnesses.com/original/Se-Sy/Sickle-cell-Anemia.html
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5Purves 10.7 6
Chromosomal Chiasmata
7http://www.sciencemag.org/cgi/content/full/287/5461/2216 8Alfred Sturtevant 1891- 1970
http://www.nature.com/ng/journal/v34/n3/full/ng0703-242.html
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9http://www.sciencemag.org/cgi/content/full/287/5461/2216
C.B. Bridges, 1937, 5 Mb of DNA on tip of Drosophila Chr. 2
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Terms
• Dominant phenotype
• Recessive phenotype
• Incomplete dominance
• Dihybrid cross
• Mendel’s 2nd Law
• Linkage
• Linkage group
• Loci
• Crossing over
• Chiasmata
• Recombinants
• Genetic Map
• Centimorgan (cM)
• Map Unit
• Recombination Frequency
• Genetic Distance
• Physical Distance
• Meosis I
• Meosis II
• Chromosomal theory