cover picture: identification of flavopiridol analogues that selectively inhibit positive...
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CBCHFX 10 (12) 1893 – 2120 (2009) · ISSN 1439-4227 · Vol. 10 · No. 12 · August 17, 2009 D55712
12/2009
www.chembiochem.org
10th
Volume
Review: Galactofuranose-Containing Polysaccharides (T. L. Lowary)
Minireview: Targeting Mitochondria with Organelle-Specific
Compounds (S. O. Kelley)
Highlight: Sequence Determinants of Prion Formation
from Genome-Wide Studies
(H. A. Lashuel, R. V. Pappu)
A Journal of
Cover Picture
Akbar Ali, Animesh Ghosh, Robin S. Nathans, Natalia Sharova,Siobhan O’Brien, Hong Cao, Mario Stevenson, and Tariq M. Rana*
The cover picture shows how a specific inhibitor of CDK9 could regulate HIV-1 replica-tion. The HIV-1 genome is integrated into a human chromosome and is transcribed byRNA polymerase II. For active viral gene expression, the HIV-1 regulatory factor Tat bindsa structured RNA hairpin loop of early nascent transcript, termed TAR RNA, and recruitsa host heterodimer kinase complex containing cyclinT1 and CDK9. A selective andpotent inhibitor of CDK9 blocks HIV-1 gene expression. For more details see the articleon by T. M. Rana et al. on p. 2072 ff. Cover illustrated by Drs. Huricha Baigude and Chia-Ying Chu.