coursedescription phar 5-10 1314 - pécsi...

UP MS Pharmacy major – 5-10th semester’s obligatory courses - Course descriptions – academic year of 2013/2014

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The University of Pécs

Medical School

PHARMACY Major

STUDY PROGRAM 2013/2014

Subjects of the

5-10th semesters (obligatory subjects and criterion requirements)


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5th semester OPG-BFM ______ Biopharmacy ________________________________________________________________________ 3 OPG-FG1 _______ Pharmacognosy 1 _____________________________________________________________________ 5 OPG-GK1 ______ Pharmaceutical Chemistry 1 ___________________________________________________________ 10 OPG-GT1 ______ Pharmaceutical Technology 1 __________________________________________________________ 13 OPO-IMM ______ Basic Immunology ___________________________________________________________________ 16 OPO-MI1 _______ Microbiology 1 _____________________________________________________________________ 18

6th semester OPG-FG2 _______ Pharmacognosy 2 ____________________________________________________________________ 20 OPG-GK2 ______ Pharmaceutical Chemistry 2 ___________________________________________________________ 26 OPG-GT2 ______ Pharmaceutical Technology 2 __________________________________________________________ 30 OPO-KOT ______ Pathophysiology _____________________________________________________________________ 32 OPO-MK2 ______ Microbiology 2 _____________________________________________________________________ 36 OPR-SG2 _______ Professional Practice 2 ________________________________________________________________ 38

7th semester OPG-GH1 ______ Pharmacodynamics 1 _________________________________________________________________ 39 OPG-GI2 _______ Pharmaceutical Practice and Management 1 _______________________________________________ 42 OPG-GK3 ______ Pharmaceutical Chemistry 3 ___________________________________________________________ 44 OPG-GT3 ______ Pharmaceutical Technology 3 __________________________________________________________ 47 OPO-KE1 ______ Public Health 1 ______________________________________________________________________ 49

8th semester OPG-GH2 ______ Pharmacodynamics 2 _________________________________________________________________ 51 OPG-GI3 _______ Pharmaceutical Practice and Management 2 _______________________________________________ 54 OPG-GK4 ______ Pharmaceutical Chemistry 4 ___________________________________________________________ 57 OPG-GT4 ______ Pharmaceutical Technology 4 __________________________________________________________ 59 OPO-KE2 ______ Public Health 2 ______________________________________________________________________ 61 OPO-KL1 ______ Clinical Studies 1 ____________________________________________________________________ 63

9th semester OPG-FID _______ Herbal Medicine and Herbs in Nutrition __________________________________________________ 65 OPG-GS3 _______ Pharmacodynamics 3 _________________________________________________________________ 68 OPG-KLF ______ Clinical Pharmacology ________________________________________________________________ 72 OPG-PMG ______ Problemsolving Pharmacy _____________________________________________________________ 74 OPG-TOX ______ Toxicology _________________________________________________________________________ 76 OPG-UI4 _______ Pharmaceutical Practice and Management 3 _______________________________________________ 78 OPO-KL2 ______ Clinical Studies 2 ____________________________________________________________________ 81 OPO-KLV ______ Clinical Laboratory Investigations _______________________________________________________ 84 OPS-SG3 _______ Professional Practice Before State Examination 1___________________________________________ 86

10th semester OPS-SG4 _______ Professional Practice Before State Examination 2___________________________________________ 88


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OPG-BFM BIOPHARMACY Course director: DR. ATTILA DÉVAY, professor Department of Pharmacotechnology

2 credit ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GT1 parallel + OPO-EL1 completed

Topic The aim of this course is to introduce biopharmaceutical features of medicines, taking into account dosage forms and routes of administration. Basic pharmacokinetic aspects (kinetics of active agents, compartmental analysis, routes of administration), some in vitro and in silico biopharmaceutical practices (using special biopharmaceutical softwares) are presented, bioequivalence studies of medicines are discussed. Students learn to design and develop pharmaceutical dosage forms according to biopharmaceutical requirements. Single- and repeated dosing calculations will be discussed according to pharmaceutical and physiological aspects.

Conditions for acceptance of the semester Accepted work report Accepted written assessments

Making up for missed classes Students must fulfil requirements determined by the Code of Studies and Examinations.

Reading material Applied biopharmaceutics and pharmacokinetics, Leon Shargel, A. B.C. Yu, Stamford Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yon Rojanasakul, Humana Press Modern pharmaceutics, Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker Inc., New York- Basel www.boomer.org www.gytsz.pte.hu www.sciencedirect.com

Lectures 1 Subject and general approach of biopharmacy Dr. Dévay Attila 2 Subject and general approach of biopharmacy Dr. Dévay Attila 3 Drug delivery systems and the input options I. Dr. Dévay Attila 4 Drug delivery systems and the input options I. Dr. Dévay Attila 5 Drug delivery systems and the input options II. Dr. Dévay Attila 6 Drug delivery systems and the input options II. Dr. Dévay Attila 7 Examination of drug-liberation Dr. Dévay Attila 8 Examination of drug-liberation Dr. Dévay Attila 9 Drug-liberation Dr. Dévay Attila 10 Drug-liberation Dr. Dévay Attila 11 WRITTEN TEST Dr. Dévay Attila 12 WRITTEN TEST Dr. Dévay Attila


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13 Drug-absorption Dr. Dévay Attila 14 Drug-absorption Dr. Dévay Attila 15 Drug-distribution and drug-metabolisms Dr. Dévay Attila 16 Drug-distribution and drug-metabolisms Dr. Dévay Attila 17 Drug-distribution and drug-metabolisms Dr. Dévay Attila 18 Drug-distribution and drug-metabolisms Dr. Dévay Attila 19 Drug-excretion Dr. Dévay Attila 20 Drug-excretion Dr. Dévay Attila 21 Biopharmaceutical analysis and modelling Dr. Dévay Attila 22 Biopharmaceutical analysis and modelling Dr. Dévay Attila 23 Biopharmaceutical tests I. Dr. Dévay Attila 24 Biopharmaceutical tests I. Dr. Dévay Attila 25 Biopharmaceutical tests II. Dr. Dévay Attila 26 Biopharmaceutical tests II. Dr. Dévay Attila 27 WRITTEN TEST Dr. Dévay Attila 28 WRITTEN TEST Dr. Dévay Attila

Practices

Seminars

Exam topics/questions

Participants dr. Börzsei Rita Judit (BORPAAO.PTE), Dr. Dévay Attila (DEAHABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE)


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OPG-FG1 PHARMACOGNOSY 1 Course director: DR. GYÖRGYI HORVÁTH, professor Department of Pharmacognosy

5 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 42 practices + 0 seminars = total of 70 hours Headcount limitations (min-max.): min. 3 – max. 40 Prerequisites: OPO-GN2 completed

Topic Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene technology, critical evaluation of holistic medicine and homeOPA-thy, possibilities of phytotherapy) and discusses the chemical composition and other qualitative characteristics, as well as the most important areas of usage, pharmacology of herbal drugs and drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are required to recognize the most important tea drugs and drugs with strong physiological effects that are traded and/or imported into Hungary. Through practices students obtain experience in drug analysis and identification methods and the ability to solve daily problems, with special emphasis on processing information from literature, databases and the internet. Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their active ingredients in general, preparing a detailed knowledge and analysis of drugs in the spring semester.

Conditions for acceptance of the semester Satisfactory completion of 1 written test based on the lectures. Completion of all laboratory practices and 4 written tests based on the material of the practices. Absences and missed practices: participation is compulsory in the lab practices, 1 absence is allowed. Students are allowed to make up for the missed lab practice, but should consult the lab instructor in advance.

Making up for missed classes Students are allowed to make up for the missed lab practice, but should consult the lab instructor in advance.

Reading material Compulsory literature: Evans W.C.: Trease and Evans Pharmacognosy. Saunders, London-New York, 2000 Recommended literature: 1. Aronson J.K. (ed): Meylers Side Effects of Herbal Medicines. Elsevier, Amsterdam-Oxford-Tokyo, 2009 2. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines. 2nd edition. Pharmaceutical Press, London-Chicago, 2002 3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products. 2nd edition. Thieme, Exeter; Stuttgart;

New York, 2003 4. Poole C.F., Poole S.K.: Chromatography Today. Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991 5. WHO Guidelines on Good Agricultural and Collection Practices (GACP) for medicinal plants, 2003

Lectures 1 Scope and subject of pharmacognosy. Dr. Farkas Ágnes 2 Scientific and Hungarian names of medicinal plants and drugs. Basic ethnobotany. Dr. Farkas Ágnes 3 Wild, protected and cultivated medicinal plants; medicinal plant breeding. Dr. Farkas Ágnes 4 Plant biotechnology, gene technology. Dr. Farkas Ágnes 5 Natural substances in pharmaceutical research. Dr. Horváth Györgyi 6 (Traditional) herbal medicines and dietary supplements. Dr. Horváth Györgyi 7 Tea drugs, primary processing of medicinal plants, plant extracts. Industrial medicinal plants. Dr. Farkas Ágnes 8 Qualification and phytochemical evaluation of medicinal plants. Dr. Farkas Ágnes 9 Phytotherapy. Dr. Horváth Györgyi


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10 Aromatherapy. Dr. Horváth Györgyi 11 Medicinal plants in homeOPA-thy. Dr. Horváth Györgyi 12 Drugs of fungal and animal origin. Dr. Horváth Györgyi 13 Photosynthesis and related metabolic pathways of effective substances. Dr. Molnár Péter 14 Role of nitrate- and sulphate-reduction in synthesis of effective substances. Dr. Molnár Péter 15 Synthesis, role of carbohydrates. Dr. Molnár Péter 16 Usage of carbohydrates. Dr. Molnár Péter 17 Synthesis, role and usage of lipids. Dr. Molnár Péter 18 Oils and waxes. Dr. Molnár Péter 19 Biosynthesis of terpenoids. Dr. Molnár Péter 20 Classification of terpenoids. Dr. Molnár Péter 21 Test. Dr. Horváth Györgyi 22 Test. Dr. Horváth Györgyi 23 Biosynthesis and role of amino acids and proteins. Dr. Molnár Péter 24 Biosynthesis and role of amino acids and proteins. Dr. Molnár Péter 25 General features of alkaloids. Dr. Molnár Péter 26 Classification of alkaloids. Dr. Molnár Péter 27 General features of phenoloids. Dr. Molnár Péter 28 Classification of phenoloids. Dr. Molnár Péter

Practices 1 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 2 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 3 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 4 Drugs with carbohydrate content. 5 Microscopic distinction of starch grains. 6 Cytochemical detection of starch and inulin. 7 Drugs containing inorganic and organic acids. 8 Drugs containing inorganic and organic acids. 9 Equiseti herba contamination with Equisetum palustre; analysis of the epidermis and other morpho-anatomical features. 10 Drugs with essential oil I. Lamiaceae. 11 Menthae piperitae folium. 12 Identification of Thymi vulgaris herba and Serpylli herba on the basis of glandular trichomes. 13 Drugs with essential oil II. Apiaceae. 14 Identification of Anisi vulgaris fructus, Carvi fructus, Foeniculi fructus, Coriandri fructus on the basis of histological

features, with the help of a drug atlas. 15 Investigation of Lupuli flos. 16 Drugs with essential oil III. Asteraceae.


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17 Investigation of Matricariae flos on the basis of Ph.Hg. VIII. 18 Distinction of Solidaginis herba and Solidaginis virgaureae herba based on micromorphological features. 19 Iridoids, diterpenes. 20 Triterpene saponins. 21 Histological comparison of Valerianae radix and Primulae radix. 22 Alkaloid-containing drugs I. Solanaceae. 23 Alkaloid-containing drugs I. Boraginaceae, Fabaceae, Papaveraceae. 24 Comparison of Belladonnae folium and Stramonii folium on the basis of cleared preparations. 25 Alkaloid-containing drugs II. Erythroxylaceae, Strychnaceae. 26 Alkaloid-containing drugs II. Rubiaceae. 27 Alkaloid-containing drugs II. Theaceae, Sterculiaceae, Apocynaceae. 28 Amino acids. 29 Peptides and proteins. 30 Identification of Phaseoli pericarpium by calcium-oxalate prisms. 31 Steroid-containing drugs. Investigation of Avenae herba. 32 Cardenolic glycosides. 33 Characterisation of Digitalis purpureae folium and Digitalis lanatae folium. 34 Phenoloids I. 35 Morphological and histological investigation of Hyperici herba. 36 Histological characterisation of Sennae folium, Sennae fructus acutifoliae and Sennae fructus angustifoliae. 37 Phenoloids II. 38 Characterisation of Cotini folium with histochemical reactions. 39 Cleared preparations of Juglandis folium. 40 Final test. 41 Final test. 42 Final test.

Seminars

Exam topics/questions 1. Scope and subject of Pharmacognosy. Herbaria. 2. Scientific and Hungarian names of medicinal plants; binomial nomenclature; pharmaceutical names of drugs. 3. Ethno-pharmacobotany. 4. Natural compounds in pharmaceutical research. 5. Classification of herbal medicines. 6. Significance of photosynthesis, structure and chemical composition of the chloroplast. Light reactions of photosynthesis. 7. The nitrogen cycle, nitrogen fixation. 8. Nitrogen assimilation and sulphate reduction. Nitrogen- and sulphur-containing compounds in the pharmaceutical practice. 9. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic

acid; C4 and CAM type plants. 10. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins,

mannans, gummi arabicum, heterOPO-lysaccharides: occurrence, medicinal usage. 11. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-α-phosphatidic acid, cholamine, choline,

serine, inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids.

12. Fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants. 13. Structure of arachidonic acid, ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Physical and

chemical parameters of fats and oils, occurrence in plants, medicinal usage. 14. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and

utilisation of waxes. 15. Prostaglandins: discovery, occurrence; chemical structure; biosynthetic precursor; biological effects, medicinal usage.

Polyacetylenes: synthesis, features, occurrence in plants, biological role. 16. IsOPR-enoid compounds I. IsOPR-ene rule; modes of linking of isOPR-ene units; natural and artificial polyisOPR-enes. 17. IsOPR-enoid compounds II. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA),

isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis. 18. IsOPR-enoid compounds III. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few

examples; occurrence, biological role, medicinal usage. 19. IsOPR-enoid compounds IV. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role,

application in medicine.


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20. IsOPR-enoid compounds V. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins.

21. Proteinogenic amino acids I.: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine, glutamic acid, glutamine, histidine, leucine, isoleucine.

22. Proteinogenic amino acids II.: Structural formula and chemical name of lysine, methionine, phenylalanine, proline, hydroxyproline, serine, threonine, tryptophan, tyrosine, valine.

23. Important amino acid reactions I. a.) Basic reaction of transamination; b.) reductive desamination -> formation of α-amino acids from α -keto acids (α -oxo acids); c.) formation of glutamine from glutamic acid.

24. Important amino acid reactions II.: a.) Decarboxylation; b.) oxidative desamination; c.) formation of asparagine from aspartic acid

25. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid and carbamide. Allantoin, as the most well-known plant ureid.

26. Specific amino acids: chemical structure of γ-amino-butyric acid (GABA), β-amino-butyric acid (BABA) and β-alanine; formation, significance in plants; chemical transformation.

27. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA-). Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

28. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromelain, ficin).

29. The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

30. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in their biosynthesis (ornitin, lysine, phenylalanine, tyrosine, tryptophan, histidine).

31. Alkaloids II. Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure).

32. Alkaloids III. Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

33. Alkaloids IV. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline).

34. Alkaloids V. TrOPA-ne alkaloids – Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortrOPA-ne, trOPA-ne, tropine (3α-hydroxi-trOPA-ne) and tropic acid. Atropine, hyosciamine, scOPO-lamine – structure, occurrence, biological effect, application in medicine and elsewhere.

35. Alkaloids VI. Structure of pseudotropine (3β-hydroxi-trOPA-ne), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect.

36. Alkaloids VII. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine. 37. Alkaloids VIII. Opium alkaloids: a.) Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid. 38. Alkaloids IX. Opium alkaloids: b.) Structure of morphine; biological effect, medical usage. Structure, biological effects and

medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. 39. Alkaloids X. LSD as the most important representative of ergot alkaloids: chemical structure, biological effects. Biological

effects and medical application of further important ergot alkaloids. 40. Alkaloids XI. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and

caffeine; occurrence, biological effects, usage. 41. Alkaloids XII. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence in plants;

usage. Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing quaternary nitrogen. The most important alkaloid-containing plant families.

42. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of β-phenyl-propionic acid, trans (E)-cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic acid and quinic acid).

43. Phenoloids II. The hydroquinone – para-benzoquinone transformation. Quinone derivatives and their significance in plant biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in plants, significance in biology and medicine.

44. Phenoloids III. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in plants.

45. Phenoloids IV. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

46. Phenoloids V. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance.


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47. Phenoloids VI. Flavonoids: Structure of α- and γ-pyran, α- and γ-pyrone and coumarin (α-pyrone condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and isolation of rutin (vitamin P).

48. Phenoloids VII. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants, biological effects and medical significance of anthocyanin colouring agents.

49. Phenoloids VIII. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-β-D-glucose. Occurrence, features and application of tannins.

50. Phenoloids IX. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.

51. Wild and protected medicinal plants, collection of medicinal plants. 52. Cultivation and breeding of medicinal plants; plant biotechnology and gene technology. 53. Tea drugs, primary processing, extracts. 54. Industrial medicinal plants. 55. Qualification and phytochemical evaluation of medicinal plants, requirements of the pharmacopoeia. 56. Phytotherapy; types, licensing and distribution of herbal medicines. 57. Aromatherapy 58. HomeOPA-thy 59. Drugs of fungal and animal origin.

Participants Dr. Farkas Ágnes (FAADAB.T.JPTE)


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OPG-GK1 PHARMACEUTICAL CHEMISTRY 1 Course director: DR. PÁL PERJÉSI, full professor Department of Pharmaceutic Chemistry

6 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPA-BY1 completed + OPA-SV1 completed + OPA-AN2 completed

Topic Introduction to the quality control of substances used in pharmaceutical compounding. PharmacOPO-eal analysis of selected inorganic substances. Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.

Conditions for acceptance of the semester Participation in both the lectures and the practices of the course is obligatory. Maximum absences from lectures and practices: three. 80% of the performed quantitative determinations should be completed. Both semester test results must exceed 60%.

Making up for missed classes Missed practices may be made up during re-take opportunities announced by the department. During each make-up session only one missed practice is allowed.

Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory Manual. University of Pécs. D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams&Wilkins,

Philadelphia, 2002 Lecture notes

Lectures 1 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeia nomenclature

of substances. Dr. Perjési Pál 2 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature

of substances. Dr. Perjési Pál 3 Identification and qualitative tests of the European Pharmacopoeia Dr. Perjési Pál 4 Identification and qualitative tests of the European Pharmacopoeia Dr. Perjési Pál 5 Physical and physicochemical methods of the European Pharmacopoeia Dr. Perjési Pál 6 Physical and physicochemical methods of the European Pharmacopoeia. Dr. Perjési Pál 7 Instrumental (IR, UV-VIS) and chromatographic (TLC, HPLC) methods of the European Pharmacopoeia. Dr. Perjési Pál 8 Instrumental (IR, UV-VIS) and chromatographic (TLC, HPLC) methods of the European Pharmacopoeia. Dr. Perjési Pál 9 Molecular mechanisms of drug action. Receptor theories. Dr. Perjési Pál 10 Molecular mechanisms of drug action. Receptor theories. Dr. Perjési Pál 11 Structural and physical chemistry of drug action. Structure-activity relationships. Dr. Perjési Pál 12 Structural and physical chemistry of drug action. Structure-activity relationships. Dr. Perjési Pál 13 Drug metabolism. Phase 1 and Phase 2 transformations. Dr. Perjési Pál 14 Drug metabolism. Phase 1 and Phase 2 transformations. Dr. Perjési Pál


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15 General anaesthetics. Dr. Perjési Pál 16 General anaesthetics. Dr. Perjési Pál 17 Sedative-Hypnotics. Dr. Perjési Pál 18 Sedative-Hypnotics. Dr. Perjési Pál 19 Narcotic analgesics and their antagonists I. Dr. Huber Imre 20 Narcotic analgesics and their antagonists. Dr. Huber Imre 21 Narcotic-analgesics and their antagonists II. Dr. Huber Imre 22 Narcotic-analgesics and their antagonists II. Dr. Huber Imre 23 Anticonvulsant drugs. Dr. Huber Imre 24 Anticonvulsant drugs. Dr. Huber Imre 25 Antipsychotics. Neuroleptics. Dr. Perjési Pál 26 Antipsychotics. Neuroleptics. Dr. Perjési Pál 27 Anxiolytics. Dr. Perjési Pál 28 Anxiolytics. Dr. Perjési Pál

Practices 1 Laboratory safety, accident protection, equipping.

Physical test and determination. Experimental error. Calculations. The pharmacopoeial nomenclature of substances.

2 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations. The pharmacopoeial nomenclature of substances.



5 Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum. Natrii chloridum, Chloraminum.




9 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 10 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 11 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 12 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 13 Oxygen and oxygen compounds. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum. 14 Oxygen and oxygen compounds. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum. 17 Sulfur and sulfur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum. 21 Nitrogen and nitrogen compounds. Ammonii chloridum. Natrii nitris. Kalii nitras, Bismuthi subnitras. 25 Phosphorus and phosphorus compounds. Calcii hydrogenphosphas, Tricalcii phosphas, Natrii dihydrogenphosphas,

Dinatrii phosphas, Arsenii trioxidum. 29 Carbon and carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas.


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33 Silicon and compounds. Alkali metals, Alkaline earth metals. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxidum, Magnesii trisilicas, Silica colloidalis hydrica.

37 Boron and aluminium compounds. Acidum boricum. Borax. Aluminii sulfas, Alumen. Aluminii oxidum hydricum 41 Transition metals I. Zinci oxidum, Zinci chloridum, Hydrargyrum chloratum amidatum (Ph.Hg.VII.), Barii sulfas 45 Transition metals II. Cupri sulfas, Ferrosi sulfas, Ferri chloridum, Kalii permanganas. 49 Complete pharmacopoeial analysis of one substance. 51 Complete pharmacopoeial analysis of one substance. 53 Complete pharmacopoeial analysis of one substance. 55 Complete pharmacopoeial analysis of one substance

Seminars

Exam topics/questions Written exam covering the topics of the lectures and laboratory practices. Further details: www.gytsz.pte.hu

Participants Dr. Rozmer Zsuzsanna (ROZQAAP.PTE)


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OPG-GT1 PHARMACEUTICAL TECHNOLOGY 1 Course director: DR. ATTILA DÉVAY, professor Department of Pharmacotechnology

7 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 70 practices + 0 seminars = total of 98 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GI1 completed + OPR-LAT completed

Topic Courses of pharmaceutical technology are taught in the third and fourth years. The aim of the courses of Pharmaceutical Technology is to introduce basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients. Further studies include overview of national and international pharmacopoeias. Practices usually begin with seminars where a basic introduction of the proper lesson takes place. After seminars students have to prepare medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculations of single and daily maximal doses, preparation, labelling and pricing. Students also have to prepare galenic formulations according to the official formula. Practices of quality control of medicines are carried out as well. Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solutions, syrups, elixirs, oral drops, ear drops, nasal drops, parenteral solutions and associated calculations with practicing quality control of the mentioned dosage forms.

Conditions for acceptance of the semester Accepted preparations made on practices Accepted work reports Accepted practical and theoretical assessments


Reading material International Pharmacopoeias European Pharmacopoeia Hungarian National Formulary: Formulae Normales VII (FoNo VII.) Encyclopedia of Pharmaceutical Technology, James Swarbrick, Informa Healthcare, New York, London Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yon Rojanasakul, Humana Press Modern Pharmaceutics, Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker Inc., New York- Basel Pharmaceutical and Clinical Calculations, Mansoor A. Khan, Indra K. Reddy, CRC Press Pharmaceutical Compounding and Dispensing, Chris Langley, Dawn Belcher, Pharmaceutical Press www.gytsz.pte.hu www.sciencedirect.com

Lectures 1 Introduction to pharmaceutical technology Dr. Dévay Attila 2 Introduction to pharmaceutical technology Dr. Dévay Attila 3 Solutions, syrups, elixirs, mixtures Dr. Dévay Attila 4 Solutions, syrups, elixirs, mixtures Dr. Dévay Attila 5 Aromatic waters, alcohol and oil based solutions Infusions, decoctions Dr. Dévay Attila 6 Aromatic waters, alcohol and oil based solutions Infusions, decoctions Dr. Dévay Attila 7 Extracts, tinctures Dr. Dévay Attila 8 Extracts, tinctures Dr. Dévay Attila 9 The physico-chemical properties of active ingredients Dr. Dévay Attila


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10 The physico-chemical properties of active ingredients Dr. Dévay Attila 11 Interaction and incompatibility of pharmaceutical preparations Dr. Dévay Attila 12 Interaction and incompatibility of pharmaceutical preparations Dr. Dévay Attila 13 Nasal and ear preparations Dr. Dévay Attila 14 Nasal and ear preparations Dr. Dévay Attila 15 Aseptic preparations Dr. Dévay Attila 16 Aseptic preparations Dr. Dévay Attila 17 Eye preparations Dr. Dévay Attila 18 Eye preparations Dr. Dévay Attila 19 Sterilization. The most important injections Dr. Dévay Attila 20 Sterilization. The most important injections Dr. Dévay Attila 21 Preparation and examination of injections Dr. Dévay Attila 22 Preparation and examination of injections Dr. Dévay Attila 23 Infusions. The most important class of injectable preparations Dr. Dévay Attila 24 Infusions. The most important class of injectable preparations Dr. Dévay Attila 25 WRITTEN TEST Dr. Dévay Attila 26 WRITTEN TEST Dr. Dévay Attila 27 Injectable and plantable preparations Dr. Dévay Attila 28 Injectable and plantable preparations Dr. Dévay Attila

Practices 0 General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions 0 Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations 0 Complex solutions, mixtures, drops 0 Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops 0 Preparation and examination of pure solutions, alcoholic solutions 0 Preparation and examination of syrups and colloid solutions 0 Preparation and examination of mucilages and colloid solutions 0 Assessment 0 Sterilizing, isotonisation, calculations, eye drops 0 Preparation of eye drops, ointments 0 Preparation and examination of injections 0 Preparation and examination of infusions 0 Preparation and examination of emulsions and suspensions 0 End-of- semester assessment


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Seminars

Exam topics/questions The end-of-semester exam will be evaluated on a 1-5 grade-point system. Knowledge acquired is tested based on subject matter defined on a list of topics provided by the institute.

Participants Dr. Mayer Klára (MAKMABO.PTE), Dr. Nagy Sándor Ferenc (NASMAAO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE)


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OPO-IMM BASIC IMMUNOLOGY Course director: DR. PÉTER NÉMETH, full professor Department of Immunology and Biotechnology

2 credits ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Headcount limitations (min-max.): min. 5 – max. 200 Prerequisites: OPA-BY1 completed + OPO-MB2 completed

Topic Introduction to the current immunobiology. Organisation of the human immune system: organs, tissues, cellular and molecular components. Regulation of immune functions: recognition, differentiation, effector functions, memory formation, suppression of the immune response, immunological tolerance. Main aspects of the physiological and pathological immune response. Basic immunOPA-thological aspects of immune related diseases including allergy, autoimmune diseases, organ transplantation, immunity against tumours.

Conditions for acceptance of the semester Participation on the lectures. No more absence as 3.

Making up for missed classes No.

Reading material A.K. Abbas, A.H. Lichtman and A. Pillai: Cellular and Molecular Immunology, 6th edition (Elsevier) More details see on www.immbio.hu

Lectures 1. Historical overview, main aspects and perspectives in the theoretical and practical immunology – immunobiology. Dr. Németh Péter 2. Historical overview, main aspects and perspectives in the theoretical and practical immunology – immunobiology. Dr. Németh Péter 3. Recognition molecules: Immunological recognition in innate, adaptive, and natural immunity. Definition of the antigen.

Molecular structures and main functions of antibodies, B cell- and T cell receptors. Dr. Németh Péter 4. Recognition molecules: Immunological recognition in innate, adaptive, and natural immunity. Definition of the antigen.

Molecular structures and main functions of antibodies, B cell- and T cell receptors. Dr. Németh Péter 5. Recognition by MHC. Antigen presentation and MHC restriction. Molecular structure of MHC, subclasses, genetics,

functions. Superantigens. Dr. Németh Péter 6. Recognition by MHC. Antigen presentation and MHC restriction. Molecular structure of MHC, subclasses, genetics,

functions. Superantigens. Dr. Németh Péter 7. Communication between cellular components of the immune system. (I.) Co-receptors and adhesion molecules. Dr. Berki Timea 8. Cytokines, cytokine receptors Dr. Berki Timea 9. Organization and rearrangement of the antigen receptor genes. Dr. Balogh Péter 10. Primary B cell development: developmental stages and checkpoints. Dr. Balogh Péter 11. Innate immunity: inflammation, leukocyte migration. Dr. Engelmann Péter 12. T-cell development in the thymus. Stages of maturation and the role of environmental factors. Dr. Berki Timea 13. The complement system. Dr. Berki Timea 14. Beginning of the immune response: early stages of T/B cell interaction, CD3 complex and signal transduction, BcR

signal transduction. Co-stimulation. T-dependent and T-independent antigens. Dr. Boldizsár Ferenc


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15. Components of the humoral immune response: extrafollicular reaction and germinal center formation. Dr. Balogh Péter 16. Development and maintenance of immunological memory, role in immune regulation (CD45 isoforms). Comparison of

the prmary and secondary immune response. Dr. Balogh Péter 17. Effector functions of immunoglobulins. Antigen-antibody reactions. IgE-mediated immunreactions. Dr. Berki Timea 18. Effector mechanisms of cell-mediated immune responses (CMI): 1. Cytotoxicity. 2. Th-cell mediated macrophage

activation (Delayed type hypersensitivity = DTH). Dr. Berki Timea 19. Systemic and local immunity (SALT, MALT). Immunological tolerance. Dr. Németh Péter 20. Systemic and local immunity (SALT, MALT). Immunological tolerance. Dr. Németh Péter 21. Hypersensitivity. Dr. Boldizsár Ferenc 22. Hypersensitivity. Dr. Boldizsár Ferenc 23. Suppression of the immune response. Autoimmunity and autoimmune diseases. Dr. Németh Péter 24. Suppression of the immune response. Autoimmunity and autoimmune diseases. Dr. Németh Péter 25. Primary immunodeficiencies. Dr. Balogh Péter 26. Acquired immunodeficiencies, pathomechanism and progression of AIDS, diagnostic and therapeutic possibilities. Dr. Najbauer József 27. Immunity against tumors. Immunological aspects of organ transplantation. Dr. Németh Péter 28. Immunity against tumors. Immunological aspects of organ transplantation. Dr. Németh Péter

Practices

Seminars

Exam topics/questions Multiple choice questions prepared according to the subject of the lectures. Details see on www.immbio.hu

Participants


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OPO-MI1 MICROBIOLOGY 1 Course director: DR. JÚLIA SZEKERES, full professor Department of Medical Microbiology and Immunology

2 credits ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 5 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Headcount limitations (min-max.): min. 1 – max. 100 Prerequisites: OPA-BY1 completed + OPO-MB2 completed

Topic During the course the morphology, physiology of microbes, the techniques of disinfection and sterilization, the basics of antimicrobial therapy and drug-use will be discussed. The host-parasite interactions, the factors playing roles in the pathogenesis of infections, the defense mechanisms of the host and the modes of prevention will be detailed.. In this semester some lecture from systematic bacteriology are given. The objective is to provide a solid microbiological basis that will contribute to understanding detailed microbiology and further pharmacological studies.

Conditions for acceptance of the semester Attendance of the lectures is up to the judgement of the student. The materials of the lectures will be a part of the examinations. The students will have to successfully complete a written test in the exam period

Making up for missed classes

Reading material Denyer SP, Hodges NA, Gorman SP: Hugo and Russell’s Pharmaceutical Microbiology, Blackwell Science Ltd 2004, ISBN: 0-

632-06467-0

Lectures 1 Introduction the subject of microbiology, Taxonomy Dr. Emődy Levente 2 Morphology and structure of bacteria - essential cell components Dr. Tigyi Zoltán 3 Morphology and structure of bacteria - accessorial cell components Dr. Tigyi Zoltán 4 The physiology of bacteria, nutration types and growth of bacteria Dr. Kocsis Béla 5 Microbial genetics I. Dr. Tigyi Zoltán 6 Microbial genetics II. Dr. Tigyi Zoltán 7 Sterilization Dr. Kerényi Mónika 8 Disinfection Dr. Kerényi Mónika 9 Microbiological evaluation of drugs. Pyrogenicity testing Dr. Kocsis Béla 10 Antimicrobial drugs - general information.Pharmacodynamic and pharmacokinetic effects Dr. Kocsis Béla 11 Inhibitiors of bacterial cell wall synthesis Dr. Kocsis Béla 12 Inhibitors of bacterial protein synthesis Dr. Kocsis Béla 13 Antibiotics that inhibit nucleic acid synthesis. Drugs that inhibit other biochemical targets Dr. Kocsis Béla 14 Mechanisms of Resistance Dr. Kocsis Béla 15 Pathogenicity and virulence Dr. Emődy Levente


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16 Immunology of infectious diseases I Dr. Polgár Beáta 17 Immunology of infectious diseases II. Dr. Polgár Beáta 18 Immunology of infectious diseases III. Dr. Polgár Beáta 19 Immunotherapy I Dr. Polgár Beáta 20 Immunotherapy II. Dr. Polgár Beáta 21 Vaccinology I. Dr. Emődy Levente 22 Vaccinology II. Dr. Emődy Levente 23 Pyogenic bacteria I Dr. Kerényi Mónika 24 Pyogenic bacteria II. Dr. Kerényi Mónika 25 Pyogenic bacteria III. Dr. Kerényi Mónika 26 Enteric bacteria and gastrointestinal pathogens I. Dr. Tigyi Zoltán 27 Enteric bacteria and gastrointestinal pathogens II. Dr. Tigyi Zoltán 28 Enteric bacteria and gastrointestinal pathogens III. Dr. Tigyi Zoltán

Practices

Seminars

Exam topics/questions Written exam consists of multiple choice question

Participants


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OPG-FG2 PHARMACOGNOSY 2 Course director: DR. GYÖRGYI HORVÁTH, professor Department of Pharmacognosy

5 credit ▪ final exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 42 practices + 0 seminars = total of 70 hours Headcount limitations (min-max.): min. 3 – max. 40 Prerequisites: OPG-FG1 completed

Topic Pharmacognosy covers general features of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene technology, critical evaluation of holistic medicine and homeOPA-thy, possibilities of phytotherapy) and discusses the chemical composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are required to be able to recognize the most important tea drugs and drugs with strong physiological effects that are traded and/or imported into Hungary. Through practices students shall gain experience in drug analysis and identification methods and the ability to solve daily problems, with special emphasis on gathering information from literature, databases and the internet. Course objective and role in the curriculum: students should become familiar with the general, phytochemical and pharmacological features of drugs applied in pharmaco- and phythotherapy.

Conditions for acceptance of the semester Criteria of acceptance of the semester: Satisfactory completion of 1 written test based on the lectures. Completion of all laboratory practices. Students have to write successful tests based on the material of the practices every week. Absences and missed practices: participation is compulsory on the lab practices, 1 absence is allowed.

Making up for missed classes Students are allowed to make up for the missed lab practice, but should consult the lab instructor in advance.

Reading material Compulsory literature: Evans W.C.: Trease and Evans Pharmacognosy. Saunders, London-New York, 2000 Recommended literature: 1. Aronson J.K. (ed): Meyler’s Side Effects of Herbal Medicines. Elsevier, Amsterdam-Oxford-Tokyo, 2009 2. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines. 2nd edition. Pharmaceutical Press, London-Chicago, 2002 3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products. 2nd edition. Thieme, United Kingdom-

Stuttgart-USA, 2003 4. Poole C.F., Poole S.K.: Chromatography Today. Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991 5. WHO Guidelines on Good Agricultural and Collection Practices (GACP) for medicinal plants, 2003 6. Györgyi Horváth: Drug Reactions in the Pharmacognosy. Teaching Supplement for the Pharmacognosy Practices.

University of Pécs, Medical School, 2011.

Lectures 1 Drugs containing monoterpenes, essential oils Dr. Horváth Györgyi 2 Drugs containing monoterpenes, essential oils Dr. Horváth Györgyi 3 Essential oils Dr. Horváth Györgyi 4 Essential oils Dr. Horváth Györgyi 5 Iridoid-containing drugs Dr. Horváth Györgyi 6 Iridoid-containing drugs Dr. Horváth Györgyi 7 Drugs containing sesquiterpenes Dr. Molnár Péter 8 Drugs containing diterpenes and terpenophenols Dr. Molnár Péter 9 Drugs containing triterpenes Dr. Molnár Péter


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10 Drugs containing steroids, saponins and cardenolides Dr. Molnár Péter 11 Drugs containing alkaloids of ornithine, lysine and phenylalanine origin Dr. Molnár Péter 12 Drugs containing alkaloids of ornithine, lysine and phenylalanine origin Dr. Molnár Péter 13 Drugs containing alkaloids of tryptophan and histidine origin Dr. Molnár Péter 14 Drugs containing alkaloids of tryptophan and histidine origin Dr. Molnár Péter 15 Purine-containing drugs Dr. Molnár Péter 16 Drugs containing specific amino acid derivatives Dr. Molnár Péter 17 Drugs containing cyanogenic glycosides Dr. Horváth Györgyi 18 Drugs containing glucosinolates Dr. Horváth Györgyi 19 Drugs containing phenylprOPA-noid derivatives Dr. Horváth Györgyi 20 Drugs containing phloroglucin derivatives Dr. Horváth Györgyi 21 Drugs containing coumarin derivatives Dr. Horváth Györgyi 22 Drugs containing furanocoumarin derivatives Dr. Horváth Györgyi 23 Drugs containing anthraquinone derivatives Dr. Horváth Györgyi 24 Drugs containing naphthoquinone derivatives Dr. Horváth Györgyi 25 Drugs containing flavonoids Dr. Horváth Györgyi 26 Drugs containing flavonoids Dr. Horváth Györgyi 27 Drugs containing polyphenols Dr. Horváth Györgyi 28 Drugs containing tannins. Dr. Horváth Györgyi

Practices 1 Accident and fire-protection instruction. 2 General methods of analysis for drugs of plant origin. 3 Nitrate detection in drinking water suitable for tea extraction and in nettle tea. 4 Analysis of carbohydrate containing drugs. 5 Analysis of carbohydrate containing drugs. 6 Honey adulteration test. 7 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 8 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 9 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 10 Analysis of essential oil containing drugs. 11 Essential oil extraction for quantitative measurements. 12 Detection of essential oil components. 13 Extraction and detection of nicotine and caffeine. 14 Extraction and detection of nicotine and caffeine. 15 Soxhlet-extraction (demonstration). 16 Extraction and detection of atropine and scOPO-lamine. 17 Extraction and detection of atropine and scOPO-lamine.


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18 Written test: Phytochemistry I. 19 Extraction and detection of alliin. 20 Extraction and detection of alliin. 21 Extraction and detection of alliin. 22 Quantitative determination of total flavonoid content. 23 Quantitative determination of total flavonoid content. 24 Quantitative determination of total flavonoid content. 25 Detection of phenoloids. 26 Detection of phenoloids. 27 Detection of phenoloids. 28 Quantitative determination of total tannin content. 29 Quantitative determination of total tannin content. 30 Quantitative determination of total tannin content. 31 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 32 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 33 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 34 Analysis of drugs containing saponins. 35 Analysis of drugs containing saponins. 36 Written test: phytochemistry II. 37 Separation of carotenoids with column chromatography (demonstration). 38 Separation of carotenoids with column chromatography (demonstration). 39 Separation of carotenoids with column chromatography (demonstration). 40 Drug identification practice: Histology and phytochemistry. 41 Drug identification practice: Histology and phytochemistry. 42 Drug identification practice: Histology and phytochemistry.

Seminars

Exam topics/questions Final exam: Students are required to demonstrate their theoretical and practical knowledge based on the material of both semesters. Students

can sit for the final exam only after a successfully completed first semester and the satisfactory completion of all practices in the second semester.

At the entrance exam students are required to identify and characterise 5 drugs. Following a successful entrance exam students draw two exam questions.

The grade of the final exam is based on the written tests of the second semester, drug identification and the result of the oral exam. Drugs to be identified at the entrance exam (according to Ph.Hg. VIII.):

Absinthii herba, Agar, Agrimoniae herba, Allii ursini herba, Aloë capensis, Althaeae radix, Anethi fructus, Anisi fructus, Anisi stellati fructus, Artemisiae (vulgaris) herba in toto, Aurantii amari epicarpium et mesocarpium, Avenae herba, Belladonnae radix, Betulae folium, Bursae pastoris herba, Calami rhizoma, Calendulae flos, Callunae vulgaris herba, Cannabis sativae fructus, Capsici fructus, Cardamomi fructus, Cardui benedicti herba, Carvi fructus, Caryophylli flos, Centaurii herba in toto, Cerasi stipes, Chamomillae romanae flos, Cichorii radix, Cinnamomi cortex, Coriandri fructus, Cotini folium, Crataegi folium cum flore, Crataegi fructus, Cucurbitae semen, Dulcamarae stipes et fructus, Ephedrae herba, Epilobii herba, Equiseti herba, Eupatorii herba in toto, Farfarae folium, Foeniculi dulcis fructus, Fragariae folium in toto, Frangulae cortex, Galegae herba, Galii veri herba, Gentianae radix, Ginkgo folium, Ginseng radix, Graminis rhizoma, Hederae helicis folium, Helianthi annui flos, Hibisci sabdariffae flos, Hippocastani semen, Hyperici herba, Ipecacuanhae radix, Juglandis folium, Juniperi pseudo-fructus, Lavandulae flos, Leonuri cardiacae herba, Lichen islandicus, Lini semen, Liquiritiae radix, Lupuli flos, Malvae sylvestris flos, Matricariae flos, Melissae folium, Menthae piperitae folium, Menyanthidis trifoliatae folium, Millefolii herba, Ononidis radix, Origani herba, Papaveris rhoeados flos, Papaveris caput, Phaseoli legumen, Plantaginis lanceolatae folium, Podophylli radix et rhizoma, Populi gemma, Primulae radix, Pruni spinosae fructus, Quercus cortex, Robiniae pseudoacaciae flos, Rosae pseudo-fructus c. seminibus/s. seminibus, Rosmarini folium, Rubi fruticosi folium, Salicis cortex, Salviae officinalis folium, Sambuci flos, Sambuci fructus, Saponariae albae radix, Saturejae herba in toto, Secale cornutum, Senna folium, Sennae fructus acutifoliae, Serpylli herba in toto, Silybi mariani fructus, Sinapis albae semen, Solani amylum, Solidaginis herba, Sophorae flos, Spiraeae herba, Tagetes flos, Tanaceti parthenii herba, Taraxaci folium, Thymi herba, Tiliae flos, Tragacantha, Urticae herba in toto, Uvae ursi folium, Valerianae radix, Verbasci flos, Visci stipes.


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Exam questions:

I. General part. Phytochemistry. 1. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic

acid; C4 and CAM type plants. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins, mannans, gummi arabicum, heterOPO-lysaccharides: occurrence, medicinal usage.

2. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-α-phosphatidic acid, cholamine, choline, serine, inositol. Structures of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids. Physical and chemical characteristics of fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants.

3. Arachidonic acid, prostaglandins: discovery, occurrence, chemical structure, biological effects, medical usage. Structure of ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and utilisation of waxes. Polyacetylenes: synthesis, features, occurrence in plants, biological role.

4. IsOPR-enoid compounds. IsOPR-ene rule; modes of linking of isOPR-ene units; occurrence, biological role, medicinal application; natural and artificial polyisOPR-enes. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA), isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few examples; occurrence, biological role, medicinal usage.

5. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role, application in medicine. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins.

6. Proteinogenic amino acids: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine, glutamic acid, glutamine, histidine, leucine, isoleucine, lysine, methionine, phenylalanine, proline, hydroxyproline, serine, threonine, tryptophan, tyrosine, valine.

7. Important amino acid reactions a.) Basic reaction of transamination; b.) reductive desemination; formation of alpha-amino acids from alpha-keto acids (alpha-oxo acids); c.) formation of glutamine from glutamic acid; d.) decarboxylation; e.) oxidative desemination; f.) formation of asparagine from aspartic acid. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid and carbamide. Allantoin, as the most well-known plant ureid.

8. Specific amino acids: chemical structure of gamma-amino-butyric acid (GABA), beta-amino-butyric acid (BABA) and beta-alanine; formation, significance in plants; chemical transformation. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA-). Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

9. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromealin, ficin). The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

10. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in their biosynthesis (ornithine, lysine, phenylalanine, tyrosine, tryptophan, histidine). Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure). Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

11. Alkaloids II. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline). TrOPA-ne alkaloids – Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortrOPA-ne, trOPA-ne, tropine (3α-hydroxi-trOPA-ne) and tropic acid. Atropine, hyosciamine, scOPO-lamine – structure, occurrence, biological effect, application in medicine and elsewhere.

12. Alkaloids III. Structure of pseudotropine (3-beta-hydroxi-trOPA-ne), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine.

13. Alkaloids IV. Opium alkaloids: Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid. Structure of morphine; biological effect, medical usage. Structure, biological effects and medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. LSD as the most important representative of ergot alkaloids: chemical structure, biological effects. Biological effects and medical application of further important ergot alkaloids.

14. Alkaloids V. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and caffeine; occurrence, biological effects, usage. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence in plants; usage. Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing quaternary nitrogen. The most important alkaloid-containing plant families.

15. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of beta-phenyl-propionic acid, trans (E)-cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic acid and quinic acid). The hydroquinone para-benzoquinone transformation. Quinone derivatives and their significance in plant biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in plants, significance in biology and medicine.


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16. Phenoloids II. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in plants. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

17. Phenoloids III. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance. Flavonoids: Structure of alpha- and gamma-pyran, alpha- and gamma-pyrone and coumarin alpha-pyrone condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and isolation of rutin (vitamin P).

18. Phenoloids IV. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants, biological effects and medical significance of anthocyanin colouring agents. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-beta-D-glucose. Occurrence, features and application of tannins.

19. Phenoloids V. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.

II. Drugs 1. Drugs containing carbohydrates: Mel depuratum, Manna, Pulpa tamarindorum, Rosae pseudo-fructus, Solani amylum, Tritici

amylum, Maydis amylum, Oryzae amylum, Lana gossypii, Agar, Acaciae gummi (Gummi arabicum), Tragacantha, Helianthus tuberosus

2. Drugs containing mucilage-like carbohydrates: Lichen islandicus, Althaeae radix, Althaeae folium, Malvae sylvestris folium et flos, Salep tuber, Graminis rhizoma, Cyamopsidis tetragonolobae semen, Farfarae folium et flos, Lini semen, Cydoniae semen

3. Carbohydrate-containing drugs stimulating non-specific immune reactions: Echinaceae radix, Eupatorii herba, Arnicae flos, Visci stipes, Calendulae flos, Tiliae flos, Foenugraeci semen

4. Drugs containing polar, non-polar fats, oils and waxes of plant origin: Lecitin, Ricini oleum virginale, Helianthi annui oleum raffinatum, Lini oleum virginale, Soiae oleum raffinatum, Carthami oleum raffinatum, Brassicae napae oleum, Arachidis oleum raffinatum, Butyrum cacao, Jojoba, Cera carnauba

5. Drugs containing essential oil: Menthae piperitae folium, Lavandulae flos, Basilici herba, Orthosiphonis folium, Melissae folium, herba, Thymi herba, Serpylli herba, Origani herba, Majoranae herba, Saturejae herba, Hyssopi herba, Salviae officinalis folium, Rosmarini folium, Rosae petalum, Juniperi pseudo-fructus, Camphora, Eucalypti folium, Carvi fructus, Coriandri fructus, Aurantii amari epicarpium et mesocarpium, Cardamomi fructus, Myrrha

6. Essential oils: Anisi aetheroleum, Aurantii amari floris aetheroleum, Aurantii dulcis aetheroleum, Carvi aetheroleum, Caryophylli floris aetheroleum, Cinnamomi zeylanici corticis aetheroleum, Citronellae aetheroleum, Coriandri aetheroleum, Eucalypti aetheroleum, Foeniculi amari fructus aetheroleum, Juniperi aetheroleum, Lavandulae aetheroleum, Limonis aetheroleum, Matricariae aetheroleum, Melaleucae aetheroleum, Menthae piperitae aetheroleum, Myristicae fragrantis aetheroleum, Neroli aetheroleum, Pini silvestris aetheroleum, Rosmarini aetheroleum, Salviae sclareae aetheroleum, Thymi aetheroleum

7. Drugs containing iridoids: Plantaginis lanceolatae folium, Euphrasiae herba, Lamii albi herba, Harpagophyti radix, Agni casti fructus, Verbenae herba, Valerianae radix, Gentianae radix, Menyanthidis trifoliatae folium, Centaurii herba, Oleae folium

8. Drugs containing sesquiterpenes: Chamomillae romanae flos, Millefolii herba, Matricariae flos, Tanaceti parthenii herba, Cynarae folium, Absinthii herba, Artemisiae vulgaris herba, Abrotani herba, Dracunculi herba, Artemisiae maritimae herba et flos, Cardui benedicti herba, Helenii radix, Arnicae flos, Petasitidis folium, rhizoma, Bardanae radix, Cichorii radix et herba, Taraxaci radix et herba, Pyrethri flos

9. Drugs containing diterpenes and triterpenes: Colophonium, Marrubii herba, Ballotae nigrae herba, Taxi bracteae folium, Liquiritiae radix, Quillajae cortex, Verbasci flos, Saponariae albae radix, Saponariae rubrae radix, Primulae radix, Polygalae radix, Pruni africanae cortex, Hederae helicis folium, Betulae folium, Veronicae herba, Ononidis radix, Herniariae herba, Solidaginis virgaureae herba, Solidagnis herba, Centellae asiaticae herba, Hippocastani semen/folium/cortex, Calendulae flos, Avenae herba

10. Drugs containing adaptogenic triterpenes, sterols and saponins: Ginseng radix, Eleuterococci radix, Urticae radix et folium, Epilobii herba, Cucurbitae semen, Dioscoreae tuber, Trigonellae foenigraeci semen, Rusci rhizoma

11. Drugs containing bufadienolides, cardenolides: Digitalis purpureae folium, Digitalis lanatae folium, Strophanthi semen, Scillae bulbus, Adonidis herba, Erysimi herba et semen, Convallariae herba, Nerii folium, Hellebori radix, Leonuri cardiacae herba

12. Drugs containing specific amino acids, amino acid derivatives and amines: Allii sativi bulbus, Allii ursini folium, Allii cepae bulbus, Bursae pastoris herba, Galegae herba, Phaseoli legumen

13. Drugs containing alkaloids of ornithine and lysine origin: Belladonnae radix et folium, Hyoscyami folium, Stramonii folium, Cocae folium, Nicotianae folium, Pulmonariae herba, Symphyti radix, Lobeliae herba, Laburni semen, Sarothamni scOPA-rii herba


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14. Drugs containing alkaloids of phenylalanine origin: Capsici fructus, Ephedrae herba, Papaveris fructus sine seminibus, Opium crudum, Chelidonii herba et radix, Fumariae herba, Berberidis radicis cortex, Colchici tuber, Ipecacuanhae radix, Boldo folium, Tubokurarin-curare

15. Drugs containing alkaloids of tryptophan origin: Secale cornutum, Rauwolfiae radix, Vincae minoris herba, Catharanthi herba, Strychni semen, Curare, Cinchonae cortex, Uncariae tomentosae radix, Passiflorae herba, Physostigmae semen

16. Drugs containing purine structure effective substances: Coffeae semen, Theae folium, Cacao semen, Guarana, Mate folium, Colae semen

17. Drugs containing terpenoid alkaloids: Aconiti tuber, Veratri rhizoma et radix, Solani herba 18. Drugs containing cyanogenic glycosides, isothiocyanate derivatives: Amygdali semen, Lini semen, Sinapis nigrae semen 19. Drugs containing phloroglucin and terpenophenol derivatives: Filicis maris rhizoma, Lupuli flos, Cannabis herba 20. Drugs containing phenol- and phenylpropionic acid derivatives: Cinnamomi cortex, Caryophylli flos, Zingiberis rhizoma,

Anisi fructus, Anisi stellati fructus, Foeniculi dulcis fructus, Asari rhizoma, Calami rhizoma, Petroselini fructus, Balsamum peruvianum, Filipendulae ulmariae herba, Salicis cortex

21. Drugs containing quinone- and anthraquinone derivatives, naphthoquinone- and dianthrone derivatives: Uvae ursi folium, Vitis-idaeae folium, Frangulae cortex, Rhamni purshianae cortex, Rhei radix, Aloe, Juglandis folium, Alkannae radix, Droserae herba, Lawsoniae folium, Sennae folium et fructus, Hyperici herba

22. Drugs containing coumarins, furocoumarins, lignans and flavanolignans: Meliloti herba, Angelicae radix, Ammeos visnagae fructus, Ammi majoris fructus, Levistici radix, Apii fructus, Podophylli rhizoma, Silybi mariani fructus

23. Drugs containing flavonoids: Tiliae flos, Sambuci flos, Equiseti herba, Crataegi folium cum flore, Crataegi fructus, Violae herba cum floris, Ginkgo folium, Stoechados flos, Populi gemma, PrOPO-lis, Ribis nigri folium

24. Drugs containing tannins, polyphenols: Galla, Quercus cortex, Ratanhiae radix, Hamamelidis folium, Tormentillae rhizoma, Anserinae herba, Gei radix et rhizoma, Agrimoniae herba, Fragariae folium, Alchemillae herba, Polygoni avicularis herba, Rubi idaei folium, Rubi fruticosi folium, Coryli folium, Myrtilli folium et fructus

Participants Dr. Horváth Györgyi (HOGAAA.T.JPTE), Dr. Molnár Péter (MOPG-AAO.PTE)


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6 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GK1 completed + OPG-GT1 completed

Topic Introduction to molecular features and structural activity relationships of selected groups of active pharmaceutical ingredients. Pharmacopoeal analysis of selected inorganic substances.

Conditions for acceptance of the semester The participation in both the lectures and the practices of the course is obligatory. Maximum absences from lectures and practices: three. 80% of the performed quantitative determinations should be completed. Both semester test results must exceed 60%.

Making up for missed classes Missed practices may be made up during the re-take opportunities announced by the department. During each re-take session only one missed practice is allowed.

Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory Manual. University of Pécs. D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams&Wilkins,

Philadelphia, 2002 Lecture notes

Lectures 1 Antidepressants. Dr. Perjési Pál 2 Antidepressants. Dr. Perjési Pál 3 Anti-Parkinson agents Dr. Huber Imre 4 Anti-Parkinson agents Dr. Huber Imre 5 Nootropics. Analeptics Dr. Huber Imre 6 Nootropics. Analeptics Dr. Huber Imre 7 Non-opioid analgesics and antipyretics. Dr. Perjési Pál 8 Non-opioid analgesics and antipyretics. Dr. Perjési Pál 9 Non-steroidal anti-inflammatory agents I Dr. Perjési Pál 10 Non-steroidal anti-inflammatory agents I Dr. Perjési Pál 11 Non-steroidal anti-inflammatory agents II Dr. Perjési Pál 12 Non-steroidal anti-inflammatory agents II Dr. Perjési Pál 13 Antiallergic antihistamines. Drugs for rheumatic gout. Dr. Perjési Pál 14 Antiallergic antihistamines. Drugs for rheumatic gout. Dr. Perjési Pál 15 Parasympathomimetics Dr. Perjési Pál


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16 Parasympathomimetics Dr. Perjési Pál 17 Parasympatholytics Dr. Perjési Pál 18 Parasympatholytics Dr. Perjési Pál 19 Sympathomimetics Dr. Perjési Pál 20 Sympathomimetics Dr. Perjési Pál 21 Sympatholytics Dr. Perjési Pál 22 Sympatholytics Dr. Perjési Pál 23 Local anesthetic agents Dr. Huber Imre 24 Local anesthetic agents Dr. Huber Imre 25 Spasmolytics. Muscle relaxants. Antitussive agents. Mucolytics. Dr. Huber Imre 26 Spasmolytics. Muscle relaxants. Antitussive agents. Mucolytics. Dr. Huber Imre 27 Drugs of gastrointestinal disorders. Dr. Huber Imre 28 Drugs of gastrointestinal disorders. Dr. Huber Imre

Practices 1 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum,

Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isOPR-opylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum (Ph.Hg.VII.)

2 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum, Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isOPR-opylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum (Ph.Hg.VII.)



5 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 6 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 7 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 8 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 9 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 10 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 11 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 12 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 13 Aldehydes and ketones. Carbohydrates. Formaldehydi solutio (35 per centum), Fructosum, Glucosum anhydricum,

Lactosum, Saccharum. 14 Aldehydes and ketones. Carbohydrates. Formaldehydi solutio (35 per centum), Fructosum, Glucosum anhydricum,



Lactosum, Saccharum.


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17 Carboxylic acids. Amino acids. Acidum benzoicum. Acidum lacticum, Acidum tartaricum, Acidum sorbicum, Acidum citricum, Natrii citras, Acidum asparticum.




21 Sedative-hypnotics I. Carbonic acid derivatives. Chloroformium (Ph.Hg.VII.) Chlorali hydras, Chlorobutanolum, Ureum, Urethanum (Ph.Hg.VII.).




25 Sedative-hypnotics II. Barbituric acid derivatives. Tautomerism. Barbitalum, Barbitalum natricum, Phenobarbitalum, Phenytoinum.




29 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 30 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 31 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 32 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 33 Non-steroidal analgesics and antipyretics. . Acidum salicylicum, Acidum acetylsalicylicum, Natrii salicylas,

Salicylamidum (Ph. Hg. VII.), Paracetamolum, Phenacetinum (Ph. Hg. VII.). 34 Non-steroidal analgesics and antipyretics. . Acidum salicylicum, Acidum acetylsalicylicum, Natrii salicylas,



Salicylamidum (Ph. Hg. VII.), Paracetamolum, Phenacetinum (Ph. Hg. VII.). 37 Non-steroidal anti-inflammatory agents. Phenazonum, Aminophenazonum (Ph.Hg.VII.), Metamizolum natricum,

Diclofenacum natricum, Indometacinum. 38 Non-steroidal anti-inflammatory agents. Phenazonum, Aminophenazonum (Ph.Hg.VII.), Metamizolum natricum,



Diclofenacum natricum, Indometacinum. 41 Autonomic nervous system drugs. Pilocarpini hydrochloridum, Atropini sulfas, Homatropini methylbromidum,

Homatropini hydrobromidum, Naphazolini hydrochloridum. 42 Autonomic nervous system drugs. Pilocarpini hydrochloridum, Atropini sulfas, Homatropini methylbromidum,



Homatropini hydrobromidum, Naphazolini hydrochloridum. 45 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 46 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 47 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 48 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 49 Complete pharmacopoeial analysis of one substance. 50 Complete pharmacopoeial analysis of one substance. 51 Complete pharmacopoeial analysis of one substance. 52 Complete pharmacopoeial analysis of one substance.


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53 The correlation between structure, the configuration and the conformation of molecules. 54 The correlation between structure, the configuration and the conformation of molecules. 55 The correlation between structure, the configuration and the conformation of molecules. 56 The correlation between structure, the configuration and the conformation of molecules.

Seminars

Exam topics/questions Oral exam covering the topics of Pharmaceutical Chemistry II and selected topics of Pharmaceutical Chemistry I. Before the exam each student must have a Minimum Requirement Test the result of which must be at least 80%. Further details: www.gytsz.pte.hu

Participants Dr. Rozmer Zsuzsanna (ROZQAAP.PTE)


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7 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 70 practices + 0 seminars = total of 98 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GT1 completed

Topic This semester includes a practice with ocular dosage forms. Special formulations of ocular dosage forms are eye ointments and oily and viscous eye drops. Other formulations such as emulsions, suspensions and semisolid dosage forms (ointment, cream, gel, paste) are also to be discussed.

Conditions for acceptance of the semester Accepted preparations made on practices Accepted work reports Accepted practical and theoretical assessment



Lectures 1 Cristallisation, polimorphy, and their pharmacetical technological aspects Dr. Dévay Attila 2 Cristallisation, polimorphy, and their pharmacetical technological aspects Dr. Dévay Attila 3 Evaporation and distillation Dr. Dévay Attila 4 Evaporation and distillation Dr. Dévay Attila 5 Extraction, Pressing Dr. Dévay Attila 6 Extraction, Pressing Dr. Dévay Attila 7 Filtration, sedimentation, centrifugation Dr. Dévay Attila 8 Filtration, sedimentation, centrifugation Dr. Dévay Attila 9 Written test Dr. Dévay Attila 10 Written test Dr. Dévay Attila 11 Dispers system. Emulsions, emulgents Dr. Dévay Attila 12 Dispers system. Emulsions, emulgents Dr. Dévay Attila


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13 Dispers system. Suspensions Dr. Dévay Attila 14 Dispers system. Suspensions Dr. Dévay Attila 15 Reologic properties of ointments, Excipients for preparation of ointments Dr. Dévay Attila 16 Reologic properties of ointments, Excipients for preparation of ointments Dr. Dévay Attila 17 Structural properties of ointments, Preparation and examinations of ointments Dr. Dévay Attila 18 Structural properties of ointments, Preparation and examinations of ointments Dr. Dévay Attila 19 Written test Dr. Dévay Attila 20 Written test Dr. Dévay Attila 21 Importance and determination of particle size Dr. Dévay Attila 22 Importance and determination of particle size Dr. Dévay Attila 23 Wrapping of pharmaceutical preparations Dr. Dévay Attila 24 Wrapping of pharmaceutical preparations Dr. Dévay Attila 25 Technology of medications for veterinary use Dr. Dévay Attila 26 Technology of medications for veterinary use Dr. Dévay Attila 27 The practical aspects of preparation of medication at a pharmacy Dr. Dévay Attila 28 The practical aspects of preparation of medication at a pharmacy Dr. Dévay Attila

Practices 0 General instructions, rules and regulations on practices, introduction to emulsions, suspensions and oinments 0 Preparation and examination of suspensions 0 Preparation and examination of magistral emulsions and ointments I. 0 Preparation and examination of magistral emulsions and ointments II. 0 Magistral ointments/creams/pastes/gels 0 Preparation and examination of ointments and creams 0 Preparation and examination of gels and pastes 0 Assessment 0 Preparation and examination of suppositories, calibration 0 Preparation and examination of rectal suppositories 0 Preparation and examination of vaginal suppositories 0 Examination of packaging materials 0 Visiting a pharmaceutical company 0 End-of- semester assessment

Seminars

Exam topics/questions The end-of-semester exam will be evaluated on 1-5 grade-point system. Knowledge acquired is tested based on subject matter defined on a list of topics provided by the institute.

Participants dr. Börzsei Rita Judit (BORPAAO.PTE), Dr. Mayer Klára (MAKMABO.PTE), Dr. Nagy Sándor Ferenc (NASMAAO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE)


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OPO-KOT PATHOPHYSIOLOGY Course director: DR. JÁNOS GARAI, professor Department of Pathophysiology and Gerontology

4 credits ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Headcount limitations (min-max.): min. 5 – no limit Prerequisites: OPO-EL2 completed

Topic The main goal of the curriculum is to acquaint students on a preclinical level with the basic dysfunctions of individual organs and organ systems, in order to familiarize them with the inherited and acquired etiological factors, with the pathogenesis and pathomechanism of diseases, and with the possible compensatory or adaptive mechanisms and system interactions. The topics covered (among others) include pathophysiologic attributes of circulation, respiration, energy homeostasis, thermoregulation, renal-, endocrine-, gastrointestinal functions, acid-base and salt-water balance with special focus on pathomechanisms fundamentally linked to target sites of the most prescribed drugs as well as on iatrogenic risks in connection with the main- and side-effects of drugs. Since the mean age of the patients is growing higher in most parts of the world, the gerontological aspects of functional changes are embedded into the curriculum throughout the course. The course is important to understand the clinical symptoms, as well as the possible pharmacological or other interventions and steps of prevention.

Conditions for acceptance of the semester Max. three absences from seminars (15%/28) may be tolerated. On the interim written test (ZH) a 50% achievement is the precondition for entering the oral exam. The person(s) not achieving 50% or not participating at the interim test must answer 10 Minimum Questions within 10 minutes in writing just prior to the oral exam. 80% achievement is the precondition for entering the exam. Passing the minimum questions in this case, however, is only a prerequisite, but is not sufficient on its own for a successful exam.

Making up for missed classes Writing an essay from the topic of the missed seminars

Reading material Basically the knowledge of topics dealt with at the lectures and seminars is the requirement at the exams. - Basic Principles of Pathophysiology (department notes for medical students 2006) edited by Professor Miklós Székely, - Color Atlas of Pathophysiology (S. Silbernagl, F. Lang), Thieme Stuttgart; New York, 2000 (useful for final preparation) - Essentials of Pathophysiology for Pharmacy (Martin M. Zdanowicz) CRC Press 2002 Hand-outs on http://www.pote.hu/index.php?page=egyseg&egy_id=150&menu=okt_anyag&nyelv=eng

Lectures 1 Inflammation & injury I Dr. Garai János 2 Inflammation & injury II Dr. Garai János 3 Pathophysiology of coronary circulation I Dr. Garai János 4 Pathophysiology of coronary circulation II Dr. Garai János 5 Disorders of cerebral circulation Dr. Garai János 6 Disorders of cerebral circulation Dr. Garai János 7 Abnormalities of blood pressure, hypertension Dr. Garai János 8 Consequences of hypertension, and prevention thereof Dr. Garai János 9 Circulatory failure, definition, forms Dr. Garai János 10 Chronic heart failure Dr. Garai János


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11 Disorders of the control of breathing, sleep apnea sy. Dr. Garai János 12 Abnormalities of gas exchange Dr. Garai János 13 Dyspnea, respiratory failure, tissue hypoxia Dr. Garai János 14 Role of buffers in acid-base balance Dr. Garai János 15 Role of breathing and the kidney in pH-homeostasis Dr. Garai János 16 Anomalies in glomerular és tubular functions Dr. Garai János 17 Acute and chronic renal failure, uraemia Dr. Garai János 18 Disorders of thermoregulation: introduction / fever Dr. Garai János 19 Disorders of thermoregulation: fever / hypo- & hyperthermia Dr. Garai János 20 Energetic balance, nutritional status Dr. Garai János 21 Obesity, metabolic syndrome Dr. Garai János 22 Diabetes mellitus (DM) syndrome: definition, classification Dr. Garai János 23 Pathogenesis of DM syndromes Dr. Garai János 24 Acute complications of DM Dr. Garai János 25 Chronic complications of DM Dr. Garai János 26 Pancreatic disorders. Dr. Garai János 27 Pathophysiology of liver function, liver damage, icterus Dr. Garai János 28 Portal hypertension, ascites, hepatic coma Dr. Garai János

Practices

Seminars 1 The contextual position of Pathophysiology in pharmacists' curriculum 2 Health and disease. Pathogens, disease course, signs & symptoms, therapy, prevention 3 ECG analysis, basic aspects 4 Common anomalies of repolarisation 5 ECG of acute myocardial infarct 6 Abnormal impulse formation 7 Abnormal impulse conduction 8 Complex ECG-abnormalities 9 Theory of respiratory function tests 10 Demonstration of respiratory function tests in practice 11 Acid-base balance, functionality of defense systems, major challenges 12 Acid-base disorders 13 Salt-water balance (Osmo- & volume homeostasis), the regulators and effectors 14 Disorders of salt-water balance 15 Disorders of metabolism I: LipOPR-oteins, hyperlipidemias, atherosclerosis 16 Disorders of metabolism II: Abnormal aminoacid metabolism, hyperuricemia, gout 17 Potassium homeostasis 18 Hyperkalemias, hypokalemias


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19 Pathophysiology of vitamins and trace elements 20 Hypo- & hypervitaminoses 21 Disorders of Ca, P homeostasis, osteOPO-rosis, osteomalacia 22 Vitamin-D, parathormone, hypo- & hypercalcemia 23 Anaemia, polycythemia 24 Disorders of hemostasis, DIC 25 Disorders of swallowing, filling- and emptying of the stomach, vomiting. 26 GI tract motility problems I: Diarrhea, constipation 27 GI tract motility problems II: ileus / Malabsorption syndromes 28 Pre-exam discussion of particular questions requested by the students.

Exam topics/questions Pathophysiology of water-soluble vitamins and trace elements Pathophysiology of fat-soluble vitamins Complete starvation Partial starvation, accelerated forms of energetic insufficiency, anorexia nervosa Obesity: criteria, classification, epidemiology, etiology and pathogenesis. Metabolic syndrome Protein deficiency, protein-calorie malnutrition, senile sarcopenia Pathobiochemistry of LDL-metabolism, hyperlipOPR-oteinemias Hypoglycemias Etiology and pathogenesis of DM1. Etiology and pathogenesis of DM2. Diabetic coma (ketoacidotic & hyperosmolar forms) Late complications of diabetes mellitus (including pathobiochemistry thereof) Pathophysiology of the pituitary, anomalies of growth Hyperthyroidism Hypothyroidism Glucocorticoid hyperfunctional states Pathophysiological aspects of glucocorticoid therapy Adrenal (cortex) insufficiency Hyperaldosteronisms Hyper- and hypocalcemia OsteOPO-rosis, osteomalacia General pathophysiology and consequences of anemias and polycythemia Deficiency anemias Aplastic anemias Hemolytic anemias Congenital and acquired coagulOPA-thies Bleeding abnormalities due to vascular factors Disorders of platelet functions Disseminated intravascular coagulation Thrombophilia, thrombosis: causes and consequences Pathophysiology of peptic ulcer Disorders of gastric filling and emptying, vomiting Malabsorption syndromes Diarrhea: causes, pathophysiological forms, consequences Bowel obstruction (ileus) Obstipation, diverticulosis Jaundice (conjugated & non-conjugated hyperbilirubinemias) Pathophysiological aspects of hepatic detoxifying system Toxic- and idiosynchratic liver damage Hepatic coma Liver cirrhosis, portal hypertension, ascites Pancreatitis (acute & chronic): pathophysiology and consequences. Hypothermia Heat stroke, malignant hyperthermia Pathophysiology of fever, its biological value, basic aspects of antifebrile strategies


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Inflammation, forms of manifestation, basic pathomechanisms Main groups and important representatives of inflammatory mediators Systemic inflammatory response syndrome (SIRS), multiple organ failure (MOF) Metabolic acidosis and alkalosis: causes, compensation, consequences Respiratory acidosis and alkalosis: causes, compensation, consequences Hyperkalaemia Hypokalaemia Mechanisms and disorders of volume regulation, abnormal distribution of extracellular fluid (edema) Mechanisms and disorders of osmoregulation, states with hypo- and hypertonicity Cardiovascular adaptation to physical exercise in healthy persons and patients with heart disease Pathophysiology of coronary insufficiency, risk factors Pathomechanism and consequences of acute myocardial infarction (AMI) Pathophysiology of heart failure CardiomyOPA-thies Cerebral hypoxia, ischemia, stroke Pulmonary hypertension. General pathophysiology and classification of systemic hypertension Primary (essential) hypertension: characteristics, etiological factors, consequences Hypertension and the kidneys (reciprocal connection) Hypertension and the adrenal gland Vasovagal syncope and other states with hypotension Circulatory shock: definition, classification, pathophysiology, phases and characteristics of microcirculation Hypovolemic shock Distributive shock Cardiogenic shock Forms of extrasystole (premature beats) Pre-excitation syndromes, forms and consequences of paroxysmal tachycardia Flutter and fibrillation: atrial and ventricular Nomotopic and passive heterotopic abnormalities of impulse formation Abnormalities of atrioventricular conduction (AV blocks) Intraventricular conduction abnormalities (bundle branch blocks) Atrial and ventricular axis deviations Primary repolarization abnormalities in the ECG: ECG in angina pectoris and acute myocardial infarction Disorders of the control of breathing. Sleep-apnea syndrome (OSAS, CSAS) Causes and consequences of increased airway resistance, chronic obstructive pulmonary disease (COPD) Alveolar hypoventilation and hyperventilation, causes and consequences Forms and mechanisms of hypoxia, ways of compensation, cyanosis Disorders of oxygen transport (abnormal hemoglobin, CO-poisoning, methemoglobinemia) Partial and complete respiratory failure, dyspnea Principles of basic respiratory function tests, parameters of restrictive and obstructive breathing mechanics Pathophysiology of glomerular filtration Disorders of tubular functions Acute renal failure: causes, forms, general and specific features Chronic renal failure: causes, characteristics and progression Uraemia Hyperuricemia, gout Disturbances of amino acid metabolism, (phenylketonuria, hyperhomocysteinaemia etc)

Participants Dr. Garai János (GAJMAAO.PTE), Dr. Garami András (GAAFAEO.PTE), Dr. Solymár Margit (SOMFAAO.PTE), Dr. Soós Szilvia (SOSFABO.PTE)


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OPO-MK2 MICROBIOLOGY 2 Course director: DR. JÚLIA SZEKERES, full professor Department of Medical Microbiology and Immunology

3 credits ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 28 lectures + 14 practices + 0 seminars = total of 42 hours Headcount limitations (min-max.): min. 1 – max. 100 Prerequisites: OPO-MI1 completed

Topic Systematic bacteriology, virology, mycology and parasitology are the main subjects of the second semester. The course is completed by a block of lectures integrating the knowledge using a clinical microbiological approach.. The objective is to provide solid knowledge on the prevention and therapy of infectious diseases.

Conditions for acceptance of the semester At the end of second semester the students will sit for written examinations (MCQ) in microbiology. The subject of the examinations is the information provided on the lectures and practices during the first and second semesters.


Reading material Denyer SP , Hodges NA, Gorman SP: Hugo and Russell’s Pharmaceutical Microbiology, Blackwell Science Ltd 2004, ISBN: 0-

632-06467-0

Lectures 1 Pathogens in respiratory tract Dr. Mestyán Gyula 2 Pathogens in respiratory tract Dr. Mestyán Gyula 3 Aerobic and anaerobic spore-forming bacteria Dr. Kocsis Béla 4 Aerobic and anaerobic spore-forming bacteria Dr. Kocsis Béla 5 Gram-negative nonfermenters Dr. Emődy Levente 6 Mycobacteria Dr. Emődy Levente 7 Anti-mycobacterial drugs Dr. Mestyán Gyula 8 Spirochaetes Dr. Kocsis Béla 9 Rickettsia, Chlamydia Dr. Kerényi Mónika 10 Zoonosis Dr. Kerényi Mónika 11 Characterization of viruses (basic concepts, structure, chemical composition, classification). Multiplication of viruses

(modes of replication, mutants, interaction between viruses) Dr. Szereday László 12 Pathogenesis of virus infections (modes and types of infection, immunity) Dr. Szereday László 13 Adenovirus, Parvovirus (Erythrovirus B19) Dr. Szereday László 14 Herpesviruses, Hepatitis viruses Dr. Szereday László 15 Papovaviruses, Polyomaviruses, Poxviruses, Slow virus infections, Prions Dr. Szereday László 16 Arboviruses, Roboviruses, Rhabdoviruses Dr. Szereday László 17 Respiratory viruses (orthomyxo-,Paramyxovitruses, Coronaviruses, RSV, Rhinoviruses) Dr. Szereday László


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18 Enteric viruses Dr. Szereday László 19 Retroviruses (HTLV-I, HTLV-II., HIV and AIDS) Dr. Szereday László 20 Prophylaxis of virus infections, chemotherapy (conventional and new vaccines, antiviral compounds, interferon) Dr. Szereday László 21 Mycology I. Dr. Mestyán Gyula 22 Mycology II. Dr. Mestyán Gyula 23 Antimycotics Dr. Mestyán Gyula 24 Parasitology I. Dr. Kocsis Béla 25 Parasitology II. Dr. Kocsis Béla 26 Antiparasitic drugs Dr. Mestyán Gyula 27 Nosocomial or iatrogenic infections I. Dr. Kocsis Béla 28 Nosocomial or iatrogenic infections II. Dr. Kocsis Béla

Practices 1 Introduction, safety regulations. The microscope, native and stained preparations 2 Introduction, safety regulations. The microscope, native and stained preparations 3 Cultivation of bacteria, media and techniques. Bacterial diagnosis.(Biochemical reactions in the identification) 4 Cultivation of bacteria, media and techniques. Bacterial diagnosis.(Biochemical reactions in the identification) 5 Serology. Molecular diagnostics. Immunotherapy. 6 Serology. Molecular diagnostics. Immunotherapy 7 Sterilisation and disinfection, Sterility and pyrogen testing. Demonstration of the effect of disinfectants on skin flora 8 Sterilisation and disinfection, Sterility and pyrogen testing. Demonstration of the effect of disinfectants on skin flora 9 Antibiotic sensitivity (Kirby-Bauer method, MIC, MBC, E-test) 10 Antibiotic sensitivity (Kirby-Bauer method, MIC, MBC, E-test) 11 Antibiotic concentration in body fluids. Detection of enzyme and compounds which neutralize antibiotics. Interactions of

antibiotics 12 Antibiotic concentration in body fluids. Detection of enzyme and compounds which neutralize antibiotics. Interactions of

antibiotics 13 Diagnostic virology, mycology and parasitology 14 Diagnostic virology, mycology and parasitology

Seminars

Exam topics/questions Written exam consists of multiple choice questions

Participants Dr. Halász Melinda (HAMFACO.PTE), Dr. Kerényi Mónika (KEMHAAP.PTE), Dr. Kocsis Béla (KOBHACE.PTE), Dr. Mestyán Gyula (MELPAAP.PTE), Dr. Polgár Beáta (POBPAAP.PTE), Dr. Szereday László (SZLPAAP.PTE), Dr. Tigyi Zoltán (TIZHAAE.PTE)


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OPR-SG2 PROFESSIONAL PRACTICE 2 Course director: DR. KLÁRA MAYER, associate professor Department of Pharmacotechnology

0 credit ▪ signature ▪ criterion requirement module ▪ spring semester ▪ recommended semester: 6 Number of hours/semester: 0 lectures + 160 practices + 0 seminars = total of 160 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GK1 completed + OPG-GT1 completed + OPR-SG1 completed

Topic The aim of a summer pharmacy practice after the semester 7 is to expand on the practical and theoretical knowledge and adaptation into pharmaceutical practice. The student is allowed to execute the practice in a pharmacy or in a clinical/hospital pharmacy. It is also allowed to split the four week practice into two, two-week practices in order to spend the practice at two places.

Conditions for acceptance of the semester Student can only work under the supervision of the tutor pharmacist or other assigned person. Brief daily report must be done during the practice and must be presented in Pharmaceutical Technology 3.

Making up for missed classes Four weeks of practice can be split into two parts due to illness.

Reading material European Pharmacopoeia Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices 1 Knowing the duties of pharmacy 2 Evaluation of prescriptions 3 Practicing preparation of liquid dosage forms under supervision 4 Examination of incoming active pharmaceutical ingredients, rules of impleation 5 Practicing usage of pharmaceutical appliances, scales 6 Basics of aseptic work 7 Observing expenditure 8 Pharmaceutical elaboration, documentation, storage 9 Practicing synonyms, pharmaceutical nomenclature, abbreviations, formulas 10 Observing preparations of Hungarian National Formulary (Formulae Normales VII.) 11 Observing pharmaceutical interactions and incompatibility, solving incompatibility 12 Pharmaceutical documentation (book for elaboration, log of sterilizing, etc.) 13 Studying pharmaceutical literature 14 Knowing medical aids, surgical bandages 15 Knowing and practicing work of assistants

Seminars

Exam topics/questions Knowledge acquired is evaluated based on reports made during pharmacy practice.

Participants Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE)


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OPG-GH1 PHARMACODYNAMICS 1 Course director: DR. GÁBOR PETHŐ, full professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Headcount limitations (min-max.): min. 5 – no limit Prerequisites: OPG-GK2 completed + OPA-BA2 completed + OPO-EL2 completed

Topic The aim of the course is to provide students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic nervous system and the cardiovascular system. It must be emphasized that the knowledge of the physiological principles is absolutely necessary for the study of this subject.

Conditions for acceptance of the semester Maximum of 25 % absence is allowed

Making up for missed classes There is no way to make up for missed lectures or seminars.

Reading material Rang, Dale, Ritter, Moore: Pharmacology, 7th edition, Elsevier Churchill Livingstone, 2012 B. G. Katzung (ed.): Basic and Clinical Pharmacology, 12th edition, Lange Medical Books/McGraw-Hill, 2012

Lectures 1 General aspects of neuropharmacology. General characterization of the autonomic nervous system Dr. Barthó Loránd 2 Cholinergic agonists Dr. Barthó Loránd 3 Cholinesterase inhibitors I Dr. Barthó Loránd 4 Cholinesterase inhibitors II Dr. Barthó Loránd 5 Muscarinic receptor antagonists I Dr. Barthó Loránd 6 Muscarinic receptor antagonists II Dr. Barthó Loránd 7 Neuromuscular blocking agents I Dr. Pethő Gábor 8 Neuromuscular blocking agents II Dr. Pethő Gábor 9 Agents acting on biosynthesis, storage, release and elimination of catecholamines I Dr. Pethő Gábor 10 Agents acting on biosynthesis, storage, release and elimination of catecholamines II Dr. Pethő Gábor 11 Adrenergic receptor agonists I Dr. Barthó Loránd 12 Adrenergic receptor agonists II Dr. Barthó Loránd 13 Adrenergic receptor antagonists I Dr. Barthó Loránd 14 Adrenergic receptor antagonists II Dr. Barthó Loránd 15 Pharmacology of calcium channels I Dr. Pethő Gábor 16 Pharmacology of calcium channels II Dr. Pethő Gábor


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17 Drugs acting on the renin-angiotensin-aldosterone system I Dr. Pethő Gábor 18 Drugs acting on the renin-angiotensin-aldosterone system II Dr. Pethő Gábor 19 Diuretics I Dr. Pethő Gábor 20 Diuretics II Dr. Pethő Gábor 21 Drugs used to treat congestive heart failure I Dr. Barthó Loránd 22 Drugs used to treat congestive heart failure II Dr. Barthó Loránd 23 Antianginal drugs I Dr. Barthó Loránd 24 Antianginal drugs II. Drugs that increase regional blood flow Dr. Barthó Loránd 25 Antihypertensive drugs I Dr. Pethő Gábor 26 Antihypertensive drugs II Dr. Pethő Gábor 27 Antiarrhythmic drugs I Dr. Pethő Gábor 28 Antiarrhythmic drugs II Dr. Pethő Gábor

Practices

Seminars 1 Introduction to pharmacodynamics I 2 Introduction to pharmacodynamics II 3 Basic mechanisms of drug actions 4 Characterization of agonist-receptor interaction I 5 Characterization of agonist-receptor interaction II 6 Characterization of agonist-receptor interaction III 7 Signal transduction mechanisms of drug receptors 8 Tachyphylaxis and tolerance to drugs 9 Mechanisms of drug antagonisms I 10 Mechanisms of drug antagonisms II 11 Transport of drugs across membranes I 12 Transport of drugs across membranes II 13 Absorption of drugs 14 Distribution of drugs 15 Biotransformation of drugs I 16 Biotransformation of drugs II 17 Excretion of drugs I 18 Excretion of drugs II 19 Pharmacokinetic parameters I 20 Pharmacokinetic parameters II 21 Pharmacokinetic parameters III 22 Pharmacokinetic parameters IV 23 Drug development 24 Drugs acting on autonomic ganglia 25 Computer program demonstrating the cardiovascular effects of agents acting on the autonomic nervous system I 26 Computer program demonstrating the cardiovascular effects of agents acting on the autonomic nervous system II 27 Local anaesthetics I 28 Local anaesthetics II


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Exam topics/questions 1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects

mediated by physicochemical interactions) 2. Characterisation of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy 3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs 4. Mechanisms of drug antagonisms 5. Transport of drugs across membranes 6. Absorption of drugs, oral bioavailability and presystemic elimination 7. Plasma protein binding and tissue distribution of drugs 8. Biotransformation of drugs 9. Excretion of drugs 10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses 11. Drug development 12. Cholinergic agonists and cholinesterase inhibitors 13. Muscarinic receptor antagonists 14. Neuromuscular blocking agents. Drugs acting on autonomic ganglia 15. Agents acting on the biosynthesis, storage, release and elimination of catecholamines 16. Adrenergic receptor agonists 17. Adrenergic receptor antagonists 18. Local anaesthetics 19. Calcium channel blockers 20. Drugs acting on the renin-angiotensin-aldosterone system 21. Diuretic drugs 22. Positive inotropic and other drugs used to treat congestive heart failure 23. Antianginal drugs. Drugs that increase regional blood flow 24. Antihypertensive drugs 25. Antiarrhythmic drugs In addition to the exam topics, an important part of the exam are questions aimed at assessing the general knowledge of the student.

Participants Dr. Barthó Loránd (BALIAAO.PTE), Dr. Borbély Éva (BOEMAAO.PTE), Dr. Gregus Zoltán (GRZMAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Simonné Dr. Hajna Zsófia Réka (HAZMABO.PTE)


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OPG-GI2 PHARMACEUTICAL PRACTICE AND MANAGEMENT 1 Course director: DR. LAJOS BOTZ, full professor Dept. of Pharmaceutics and University Pharmacy

3 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 0 practices + 14 seminars = total of 42 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GI1 completed + OPG-GK1 completed + OPG-GT1 completed

Topic The course examines the basic functioning of the medical market, the fundamentals and specifications of economic relations. It also aims to demonstrate the specific professional methods for the evaluation of drug therapies. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures in pharmaceutical studies: Basic aim of these lectures is to further strengthen pharmacy practice and related economic knowledge in order to understand pharmacoeconomics, drug allocation, pharmaceutical management, health economics, evidence based medicine and in general pharmaceutics. This knowledge will support later studies in these fields. A further goal is to help students gain insight into practical pharmaceutical work and into other professional studies. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills.

Conditions for acceptance of the semester Midterm examination: oral and written. Accepting criteria of semester: attendance of at least 75 % of lectures, successful exam.

Making up for missed classes Compensation is possible following personal discussion.

Reading material All presentations can be downloaded from the website of the Department: (http://aok.pte.hu/index.php?page=egyseg&egy_id=50&nyelv=hun&menu=okt_anyag). Principles of Pharmacoeconomics, Ed.: J.L. Bootman, R. J. Townsend, W. F. McGhan, Harvey Whitney Book Company, 2002. Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, Sixth Edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, Sixteenth Edition, American Pharmacists

Association, 2009.

Lectures 1 Drug Research and Development. Dr. Botz Lajos 2 Drug authorization process. Dr. Botz Lajos 3 Patent of drugs. Dr. Botz Lajos 4 Variations of authorization processes (orphan drugs, generics). Dr. Botz Lajos 5 Nonclinical studies, preclinical development. Design and methodology in clinical trials. Dr. Fittler András Tamás 6 The coffee study. Dr. Fittler András Tamás 7 Clinical trials I. Dr. Baliné Dr. Háber Ágota 8 Clinical trials II. Dr. Baliné Dr. Háber Ágota 9 Clinical trials III. Dr. Baliné Dr. Háber Ágota 10 Monitoring clinical trials. Dr. Botz Lajos 11 Equivalences of drugs I. Dr. Botz Lajos 12 Equivalences of drugs II. Dr. Botz Lajos


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13 Pharmacovigilance I. Dr. Botz Lajos 14 Pharmacovigilance II. Dr. Botz Lajos 15 Organisation of the Hungarian health care system I. Dr. Fittler András Tamás 16 Organisation of Hungarian health care system II. Dr. Fittler András Tamás 17 The drug supply chain, participants in the drug market. Dr. Fittler András Tamás 18 Social insurance in Hungary. Dr. Fittler András Tamás 19 Requirements for the opening and operation of pharmacies. Dr. Fittler András Tamás 20 Regulation of public drug supply. Dr. Fittler András Tamás 21 Fundamentals of economics I. Dr. Fittler András Tamás 22 Fundamentals of economics II. Dr. Fittler András Tamás 23 Fundamentals of economics III. Dr. Fittler András Tamás 24 Fundamentals of economics IV. Dr. Fittler András Tamás 25 Fundamentals of economics V. Dr. Fittler András Tamás 26 Fundamentals of economics VI. Dr. Fittler András Tamás 27 Fundamentals of economics VII. Dr. Fittler András Tamás 28 Exam, test. Dr. Botz Lajos

Practices

Seminars 1 Basics of communication. 2 Communication skills in pharmacy practice I. 3 Communication skills in pharmacy practice II. 4 Medication safety and communication. 5 Good practice of dispensing non prescription medications I. 6 Good practice of dispensing non prescription medications II. 7 Good practice of dispensing non prescription medications III. 8 Good practice of dispensing non prescription medications IV. 9 Good practice of dispensing non prescription medications V. 10 Good practice of dispensing non prescription medications VI. 11 Good practice of dispensing non prescription medications VII. 12 Good practice of dispensing non prescription medications VIII. 13 Good practice of dispensing non prescription medications IX. 14 Exam, test.

Exam topics/questions Based on the topics of the lectures and seminars.

Participants Dr. Baliné Dr. Háber Ágota (BAHRABO.PTE), Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE)


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7 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 42 lectures + 56 practices + 0 seminars = total of 98 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GK2 completed + OPG-GT2 completed

Topic Introduction to the most important analytical methods and their applications to pharmacOPO-eal qualification of active pharmaceutical ingredients and experiments. Introduction to the molecular aspect and structure-activity relationship of selected groups of active pharmaceutical ingredients.


Making up for missed classes Missed practices may be made up during the opportunities announced by the department. During each make-up session only one missed practice is allowed.

Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory manual. University of Pécs. D.A. Williams, T.L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams & Wilkins,

Philadelphia, 2002.

Lectures 1 Application of CD and ORD spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 2 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 3 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 4 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 5 Application of fluorimetry in pharmaceutical analysis. Dr. Kőszegi Tamás 6 Application of fluorimetry in pharmaceutical analysis. Dr. Kőszegi Tamás 7 Application of atomic absorption spectrometry and flame photometry in pharmaceutical analysis. Dr. Perjési Pál 8 Application of IR spectroscopy in pharmaceutical analysis. Dr. Lóránd Tamás 9 Application of IR spectroscopy in pharmaceutical analysis. Dr. Lóránd Tamás 10 Application of thermoanalytic methods in pharmaceutical analysis. Dr. Perjési Pál 11 Agents of cardiac failure. Dr. Perjési Pál 12 Agents of cardiac failure. Dr. Perjési Pál 13 Agents of antiarrythmic agents. Dr. Perjési Pál 14 Agents of antiarrythmic agents. Dr. Perjési Pál 15 Antihypertensire agents. Dr. Perjési Pál


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16 Antihypertensire agents. Dr. Perjési Pál 17 Diuretics. Dr. Perjési Pál 18 Diuretics. Dr. Perjési Pál 19 Antianginal drugs. Dr. Perjési Pál 20 Antianginal drugs. Dr. Perjési Pál 21 Antihyperlidemic agents. Dr. Perjési Pál 22 Antihyperlidemic agents. Dr. Perjési Pál 23 Antithrombotics, Thrombolytics, Coagulants. Dr. Perjési Pál 24 Antithrombotics, Thrombolytics, Coagulants. Dr. Perjési Pál 25 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 26 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 27 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 28 Application of mass spectrometry in pharmaceutical analysis. Dr. Perjési Pál 29 Application of NMR spectroscopy in pharmaceutical analysis. Dr. Berente Zoltán 30 Application of NMR spectroscopy in pharmaceutical analysis. Dr. Berente Zoltán 31 Introduction to separation techniques. Dr. Perjési Pál 32 Introduction to separation techniques. Dr. Perjési Pál 33 Application of TLC in pharmaceutical analysis. Dr. Perjési Pál 34 Application of TLC in pharmaceutical analysis. Dr. Perjési Pál 35 Application of HPLC in pharmaceutical analysis. Dr. Perjési Pál 36 Application of HPLC in pharmaceutical analysis. Dr. Perjési Pál 37 Application of GC in pharmaceutical analysis. Dr. Perjési Pál 38 Application of GC in pharmaceutical analysis. Dr. Perjési Pál 39 Application of gel chromatography in pharmaceutical analysis. Dr. Perjési Pál 40 Application of capillary electrophoresis in pharmaceutical analysis. Dr. Perjési Pál 41 Application of capillary electrophoresis in pharmaceutical analysis. Dr. Perjési Pál 42 Application of immunoassay techniques in pharmaceutical analysis. Dr. Perjési Pál


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Practices 1 Laboratory safety, accident protection, equipping. 2 Preliminary testing and classification of inorganic and organic compounds I. Identification of 20 inorganic and organic substances I. 5 Preliminary testing and classification of inorganic and organic compounds II. Identification reactions of inorganic

cations and anions. Identification of 20 inorganic and organic substances II. 9 Preliminary testing and classification of inorganic and organic compounds III. Identification reactions of organic functional groups. Identification of 20 inorganic and organic substances II. 13 Validation of analytical methods. Important performance characteristics. Validation of a titrimetric method. Comparison

of different methods, calculation of some performance characteristics. 17 Spectrophotometry I. Definition of Lambert-Beer’s law . Determination of specific absorbance. Spectrophotometric

determination of drug mixtures containing two components. 21 Spectrophotometry II. Determination of drug mixtures containing salicylic acid and acetylsalicylic acid by

spectrophotometric and alkalimetric methods. 25 Spectrophotometry III. Determination of isoniazid drugs by spectrophotometric and bromatometric methods. 29 Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Calibration of pH-

meter. Determination of a mixture containing a strong and a weak acid. 33 Potentiometry II. Electrodes used in potentiometry. Determination of the pKa os ascorbic acid by direct potentiometric

titration. 37 Potentiometry III. Polarography, amperometry. Determination of water by the Karl Fischer method. Determination of

protonation constants of paracetamol by difference titration. 41 Spectrophotometry IV. Buffer solutions. Determination of the pKa of benzocaine by spectrophotometry. 45 The principles of thin-layer chromatography and denzitometry. The characterization of gelchromatography. TLC

investigation of C1-C5 alcohols. The separation of serum albumine and sodium chloride by gel chromatographic method. 49 The principles of high pressure liquid chromatography. Determination of 4-nitrophenol, 4-nitrophenyl-glucuronide and 4-

nitrophenol-sulphate by HPLC method. 53 The principles of gas chromatography. Determination of salicylic acid and metabolites by GC method

Seminars

Exam topics/questions Written exam based on the topics of the lectures and the laboratory practices. Further details: www.gytsz.pte.hu

Participants Dr. Kuzma Mónika (KUMFABO.PTE)


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7 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 70 practices + 0 seminars = total of 98 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GK2 completed + OPG-GT2 completed

Topic Mainly semisolid- dosage forms are prepared in this semester: Suppositories and vaginal suppositories. Powders and capsules as solid dosage forms are also prepared and discussed.


Making up for missed classes Students must fulfil requirements stated in the Code of Studies and Examinations.

Reading material International Pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII.) Encyclopedia of Pharmaceutical Technology, James Swarbrick, Informa Healthcare, New York, London Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yon Rojanasakul, Humana Press Modern Pharmaceutics, Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker Inc., New York- Basel Pharmaceutical and Clinical Calculations, Mansoor A. Khan, Indra K. Reddy, CRC Press Pharmaceutical Compounding and Dispensing, Chris Langley, Dawn Belcher, Pharmaceutical Press www.gytsz.pte.hu www.sciencedirect.com

Lectures 1 Milling and grinding Dr. Dévay Attila 2 Milling and grinding Dr. Dévay Attila 3 Drying, freeze-drying Dr. Dévay Attila 4 Drying, freeze-drying Dr. Dévay Attila 5 Cristallisation, polimorphy, and their pharmaceutical technological aspects Dr. Dévay Attila 6 Cristallisation, polimorphy, and their pharmaceutical technological aspects Dr. Dévay Attila 7 Fluidization and its application Dr. Dévay Attila 8 Fluidization and its application Dr. Dévay Attila 9 Preparation of granules Dr. Dévay Attila 10 Preparation of granules Dr. Dévay Attila 11 From the molecule to the preparation (drug design) Dr. Dévay Attila 12 From the molecule to the preparation (drug design) Dr. Dévay Attila


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13 Tabletting I Dr. Dévay Attila 14 Tabletting I Dr. Dévay Attila 15 Tabletting II Dr. Dévay Attila 16 Tabletting II Dr. Dévay Attila 17 Tabletting excipients, examinations Dr. Dévay Attila 18 Tabletting excipients, examinations Dr. Dévay Attila 19 Dragee, preparation and examination of coated tablets Dr. Dévay Attila 20 Dragee, preparation and examination of coated tablets Dr. Dévay Attila 21 WRITTEN TEST Dr. Dévay Attila 22 WRITTEN TEST Dr. Dévay Attila 23 Pharmaceutical capsules Dr. Dévay Attila 24 Pharmaceutical capsules Dr. Dévay Attila 25 Quality Assurance, Quality Control, GMP Dr. Dévay Attila 26 Quality Assurance, Quality Control, GMP Dr. Dévay Attila 27 Official approval of manufactured preparations, validation, reproducibility, process control Dr. Dévay Attila 28 Official approval of manufactured preparations, validation, reproducibility, process control Dr. Dévay Attila

Practices 0 General instructions, rules and regulations on practices, introduction to solid forms 0 Undivided (bulk) powders, dusting powders, species I. 0 Undivided (bulk) powders, dusting powders, species II. 0 Divided powders I. 0 Divided powders II. 0 Dusting powders 0 Pills, hard gelatin capsules 0 Assessment 0 Preparation of garnules I., drying 0 Preparation of garnules II., examinations 0 Tabletting I., Machines 0 Tabletting II., Direct compression 0 Sugar and film coating processes 0 End-of- semester assessment

Seminars


Participants dr. Börzsei Rita Judit (BORPAAO.PTE), Dr. Mayer Klára (MAKMABO.PTE), Dr. Nagy Sándor Ferenc (NASMAAO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE)


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OPO-KE1 PUBLIC HEALTH 1 Course director: DR. ISTVÁN KISS, full professor Department of Public Health Medicine

2 credits ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 7 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Headcount limitations (min-max.): min. 2 – no limit Prerequisites: OPO-EL2 completed + OGOMK2 completed

Topic The subject Public health represents the preventive side of medicine. The subject deals with the primary, secondary, tertiary prevention of the most important diseases in our time using the conventional and the molecular/genomical epidemiology. The aim of the subject is to demonstrate the process from health to disease and to demonstrate the preventive possibilities at the individual and community levels.

Conditions for acceptance of the semester Oral exam


Reading material Tompa (editor): Basic Principles of Public health (ISBN: 978 963 9879 13 3) Maxcy, Rosenau, Last: Public Health and Preventive Medicine, 14th edition, Appleton and Lange (ISBN 0-8385-6185-3)

Lectures 0 History of public health Dr. Szabó István 0 Scope of preventive medicine Dr. Szabó István 0 Global overview of health status Dr. Szabó István 0 Demography, basics of epidemiology Dr. Szabó István 0 Applied epidemiology Dr. Szabó István 0 Nutritional epidemiology Dr. Szabó István 0 Healthy nutrition, macro- and micronutrients I. Dr. Szabó István 0 Healthy nutrition, macro- and micronutrients II. Dr. Szabó István 0 Foodborne non-infectious diseases Dr. Szabó István 0 Foodborne infections Dr. Szabó István 0 Genetically modified organism Dr. Varjas Tímea 0 Microbiological and chemical food safety Dr. Szabó István 0 Molecular epidemiology Dr. Varjas Tímea 0 Health problems of children and youth Dr. Szabó István 0 Health problems of aged people Dr. Szabó István 0 Epidemiology of cardiovascular diseases Dr. Szabó István 0 Epidemiology of cerebrovascular diseases, epidemiology of hypertension Dr. Varjas Tímea


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0 Predictive epidemiology of cancer Dr. Szabó István 0 Cancer prevention, cancer screening Dr. Varjas Tímea 0 Epidemiology of addictions - Epidemiology of smoking Dr. Szabó István 0 Smoking and cancer Dr. Varjas Tímea 0 Epidemiology of addictions - Epidemiology of alcohol consumption Dr. Varjas Tímea 0 Epidemiology of addictions - Health effects of drug abuse Dr. Szabó István 0 Epidemiology of osteOPO-rosis Dr. Varjas Tímea 0 Epidemiology of diabetes Dr. Szabó István 0 Epidemiology of accidents and violent deaths Dr. Szabó István 0 Epidemiology of suicide, epidemiology of mental disorders Dr. Szabó István 0 Epidemiology of other non-infectious diseases Dr. Szabó István

Practices

Seminars


Participants


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OPG-GH2 PHARMACODYNAMICS 2 Course director: DR. GÁBOR PETHŐ, full professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Headcount limitations (min-max.): min. 5 – no limit Prerequisites: OPG-GH1 completed + OPG-GK3 completed + OPG-GT3 completed

Topic The aim of the course is to provide students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the blood, pharmacology of histamine, serotonin and eicosanoids, pharmacology of the respiratory tract and the gastrointestinal tract, pharmacology of the central nervous system. Drug abuse and dependence as well as non-steroidal anti-inflammatory drugs will also be discussed.

Conditions for acceptance of the semester Maximum of 25 % absence is allowed



Lectures 1 Drugs used to treat hyperlipOPR-oteinaemias I Dr. Borbély Éva 2 Drugs used to treat hyperlipOPR-oteinaemias II Dr. Borbély Éva 3 Drugs affecting haemostasis I Dr. Pethő Gábor 4 Drugs affecting haemostasis II Dr. Pethő Gábor 5 Drugs affecting haemostasis III Dr. Pethő Gábor 6 Drugs affecting haemostasis IV Dr. Pethő Gábor 7 Drugs affecting haematOPO-iesis I Dr. Simonné Dr. Hajna Zsófia Réka 8 Drugs affecting haematOPO-iesis II Dr. Simonné Dr. Hajna Zsófia Réka 9 Introduction into the pharmacology of the central nervous system I Dr. Barthó Loránd 10 Introduction into the pharmacology of the central nervous system II Dr. Barthó Loránd 11 Antianxiety and hypnotic drugs I Dr. Barthó Loránd 12 Antianxiety and hypnotic drugs II Dr. Barthó Loránd 13 Pharmacology of alcohols I Dr. Barthó Loránd 14 Pharmacology of alcohols II Dr. Barthó Loránd 15 Antipsychotic drugs I Dr. Barthó Loránd 16 Antipsychotic drugs II Dr. Barthó Loránd


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17 Antidepressants I Dr. Barthó Loránd 18 Antidepressants II Dr. Barthó Loránd 19 Antiepileptic drugs I Dr. Pethő Gábor 20 Antiepileptic drugs II. Centrally-acting muscle relaxants Dr. Pethő Gábor 21 Opioid analgesic drugs I Dr. Barthó Loránd 22 Opioid analgesic drugs II Dr. Barthó Loránd 23 Opioid analgesic drugs III Dr. Barthó Loránd 24 Opioid analgesic drugs IV Dr. Barthó Loránd 25 Non-steroidal antiinflammatory drugs I Dr. Pethő Gábor 26 Non-steroidal antiinflammatory drugs II Dr. Pethő Gábor 27 Non-steroidal antiinflammatory drugs III Dr. Pethő Gábor 28 Adjuvant analgesics. Drugs used to treat gout. Dr. Pethő Gábor

Practices

Seminars 1 Histamine, H1 receptor antagonists 2 H2 receptor antagonists 3 Serotonin, serotonin receptor agonists 4 Serotonin receptor antagonists 5 Pharmacology of eicosanoids 6 Drugs acting on the smooth muscle including uterine muscle 7 Pharmacology of the respiratory tract I 8 Pharmacology of the respiratory tract II 9 Pharmacology of the respiratory tract III 10 Pharmacology of the respiratory tract IV 11 Pharmacology of the gastrointestinal tract I 12 Pharmacology of the gastrointestinal tract II 13 Pharmacology of the gastrointestinal tract III 14 Pharmacology of the gastrointestinal tract IV 15 Pharmacology of the gastrointestinal tract V 16 Pharmacology of the gastrointestinal tract VI 17 General anaesthetics I 18 General anaesthetics II 19 Drug treatment of neurodegenerative disorders I 20 Drug treatment of neurodegenerative disorders II 21 Central nervous system stimulants I 22 Central nervous system stimulants II. Nootropic drugs 23 Drug abuse I 24 Drug abuse II 25 Drug abuse III 26 Drug abuse IV 27 Harmful effects of drugs and their mechanisms I 28 Harmful effects of drugs and their mechanisms II


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Exam topics/questions 1. Antianxiety and hypnotic drugs 2. Alcohols: pharmacology, toxicology 3. Antipsychotic drugs 4. Antidepressants 5. Central nervous system stimulants. Nootropic drugs 6. Drug treatment of neurodegenerative disorders 7. General anaesthetics 8. Antiepileptic drugs 9. Opioid analgesic drugs: morphine and codeine 10. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists 11. Non-steroidal antiinflammatory drugs: aspirin, paracetamol 12. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol 13. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants 14. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants 15. Drugs used to treat hyperlipOPR-oteinaemias 16. Drugs affecting haemostasis 17. Drugs affecting haematOPO-iesis 18. Histamine, H1 and H2 receptor antagonists 19. Serotonin, serotonin receptor agonists and antagonists 20. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine

muscle 21. Drugs used in bronchial asthma 22. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents 23. Drugs used in the treatment of peptic ulcer 24. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis 25. Laxatives, antidiarrhoeal agents, drug treatment of inflammatory bowel diseases 26. Harmful effects of drugs and their mechanisms In addition to the exam topics, an important part of the exam are questions that aim at assessing the general knowledge of the

student.

Participants Dr. Barthó Loránd (BALIAAO.PTE), Dr. Borbély Éva (BOEMAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Simonné Dr. Hajna Zsófia Réka (HAZMABO.PTE)


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OPG-GI3 PHARMACEUTICAL PRACTICE AND MANAGEMENT 2 Course director: DR. LAJOS BOTZ, full professor Dept. of Pharmaceutics and University Pharmacy

5 credit ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 18 practices + 24 seminars = total of 70 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GH1 completed + OPG-GI2 completed + OPG-GT3 completed

Topic The course examines basic functions of the health care system and pharmaceutical supply system; with respect to general legal, pharmaceutical, economical (marketing) relations and specialities. The undergraduates acquire knowledge of the innovation of a new drug from a drug candidate, the formation of the legal validity of official indications, as well as grouping and professional explanation of unwanted effects. Methods of comprehensive analysis, evaluation and development of drug therapy, the framework and regulation of the pharmaceutical supply system will be covered throughout the semester. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures are to consolidate students’ legal, marketing and pharmacoeconomical knowledge (pharmaceutical management, health economy, pharmaceutical supply, pharmacoeconomy, evidence based medicine and pharmaceutics), and to lay the foundations of practical pharmaceutical work and further professional development. Interactive group work during the seminars will encourage problem solving skills and creative thinking.

Conditions for acceptance of the semester Midterm examination: oral and written. Midterm grade: written final examination. Acceptance criteria of semester: attendance of at least 75 % of lectures, successful exam.

Making up for missed classes Compensation is possible following personal discussion.

Reading material All presentations can be downloaded from the website of the Department: (http://aok.pte.hu/index.php?page=egyseg&egy_id=50&menu=okt_anyag&nyelv=eng). Robert S. Beardsley, Carole L. Kimberlin, William N. Tindall: Communication Skills in Pharmacy Practice, Sixth Edition, Wolters

Kluwer, Lipincott Williams & Wilkins, 2012. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, Sixteenth Edition, American Pharmacists

Association, 2009. Walker, Roger: Clinical Pharmacy and Therapeutics, 2011.

Lectures 1 Pharmaceutical Care I. Dr. Télessy István 2 Pharmaceutical Care II. Dr. Télessy István 3 Pharmaceutical Care - Metabolic syndrome I. Dr. Télessy István 4 Pharmaceutical Care - Metabolic syndrome II. Dr. Télessy István 5 Introduction to hospital and clinical pharmacy I. Dr. Fittler András Tamás 6 Introduction to hospital and clinical pharmacy II. Dr. Fittler András Tamás 7 Hospital pharmacy services I. 8 Hospital pharmacy services II. 9 Pharmaceutical law and Pharmaceutical organisations I. Dr. Mohay Ágoston Csanád 10 Fundamentals and legal basic terms. Dr. Mohay Ágoston Csanád 11 The Constitution, Acts, Laws, Regulations, Directives. Dr. Mohay Ágoston Csanád


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12 Patient rights, obligations. Dr. Mohay Ágoston Csanád 13 Health care professional rights and obligations. Dr. Fittler András Tamás 14 The European Union. Dr. Fittler András Tamás 15 International Pharmaceutical Organizations. Dr. Fittler András Tamás 16 National Pharmaceutical Organizations. Dr. Fittler András Tamás 17 Pharmaceutical law and Pharmaceutical organisations II. Dr. Fittler András Tamás 18 Fundamentals of Health Economics, Health Policy. Dr. Botz Lajos 19 Health Care Systems, Insurance Models. Dr. Botz Lajos 20 The Costs of Health Care, The Benefits of Health Care. Dr. Botz Lajos 21 Health Expenditures, Prices of Drugs/Health Care Services, Cost Control Technique. 22 Main Pharmacoeconomic Evaluations 1. Theoretical. 23 Main Pharmacoeconomic Evaluations 2. Practical. 24 The pharmaceutical and healthcare market. Dr. Fittler András Tamás 25 Marketing mix, Motivations of the customer. Dr. Fittler András Tamás 26 SWOT analysis, BCG matrix. Dr. Fittler András Tamás 27 Patents, trade marks, brand building. Dr. Fittler András Tamás 28 Life cycle management, Product strategies. Dr. Fittler András Tamás

Practices 1 Good practice of dispensing non prescription medications I. 2 Good practice of dispensing non prescription medications II. 3 Good practice of dispensing non prescription medications III. 4 Good practice of dispensing non prescription medications IV. 5 Good practice of dispensing non prescription medications V. 6 OGood practice of dispensing non prescription medications VI. 7 Good practice of dispensing non prescription medications VII. 8 Good practice of dispensing non prescription medications VIII. 9 Good practice of dispensing non prescription medications IX. 10 Good practice of dispensing non prescription medications X. 11 Good practice of dispensing non prescription medications XI. 12 Good practice of dispensing non prescription medications XII. 13 Good practice of dispensing non prescription medications XIII. 14 Good practice of dispensing non prescription medications XIV. 15 Strategies to meet specific needs I. 16 Strategies to meet specific needs II. 17 Pharmacovigilance III. 18 Pharmacovigilance IV.


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Seminars 1 Communication skills in hospital practice I. 2 Communication skills in hospital practice II. 3 Electronic communication is healthcare. 4 Pharmacovigilance I. 5 Pharmacovigilance II. 6 Pharmaceutical Care III. 7 Pharmaceutical Care IV. 8 Pharmaceutical Care V. 9 Pharmaceutical Care - Metabolic syndrome III. 10 Pharmaceutical Care - Metabolic syndrome IV. 11 Hospital pharmacy services III. 12 Interactive appraisal of topics discussed during the lectures, dispute and case study. 13 Interactive appraisal of topics discussed during the lectures, dispute and case study. 14 Pharmacoeconomic consequences of (non)-compliance/adherence. 15 Decision Analysis. 16 Decision Tree. 17 Drug Utilization Studies. 18 SOJA. 19 Quality of Life I. 20 Quality of Life II. 21 Interactive appraisal of topics discussed during the lectures, dispute and case study. 22 Pricing strategies, Distribution. 23 Advertising medicines I. 24 Advertising medicines II.


Participants


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6 credit ▪ final exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GK3 completed + OPG-GT3 completed

Topic Introduction to quality control of compounded preparations. Application of instrumental methods in pharmacopoeal quality control of pharmaceutical preparations. Introduction of molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients.


Making up for missed classes Missed practices may be made up during the opportunities announced by the department. During each make-up session only one missed practice is allowed.

Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory Manual. University of Pécs. D.A. Williams, T.L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams & Wilkins,

Philadelphia, 2002.

Lectures 1 Adrenocorticoids. Dr. Perjési Pál 2 Adrenocorticoids. Dr. Perjési Pál 3 Estrogens, Androgens, Progestins. Dr. Perjési Pál 4 Estrogens, Androgens, Progestins. Dr. Perjési Pál 5 Drugs affecting calcium homeostatis. Dr. Perjési Pál 6 Drugs affecting calcium homeostatis. Dr. Perjési Pál 7 Insulin and oral hypoglycemic drugs. Dr. Perjési Pál 8 Insulin and oral hypoglycemic drugs. Dr. Perjési Pál 9 Drug affecting thyroid functions. Dr. Perjési Pál 10 Drug affecting thyroid functions. Dr. Perjési Pál 11 Vitamins. Dr. Perjési Pál 12 Vitamins. Dr. Perjési Pál 13 Antiparasitic agents. Dr. Perjési Pál 14 Antiparasitic agents. Dr. Perjési Pál 15 Antifungal drugs. Dr. Perjési Pál


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16 Antifungal drugs. Dr. Perjési Pál 17 Antimicrobial agents. Dr. Perjési Pál 18 Antimicrobial agents. Dr. Perjési Pál 19 Antibiotics I. Dr. Lóránd Tamás 20 Antibiotics I. Dr. Lóránd Tamás 21 Antibiotics II. Dr. Lóránd Tamás 22 Antibiotics II. Dr. Lóránd Tamás 23 Antibiotics III. Dr. Lóránd Tamás 24 Antibiotics III. Dr. Lóránd Tamás 25 Anticancer agents. Dr. Perjési Pál 26 Anticancer agents. Dr. Perjési Pál 27 Antiviral agents. Dr. Perjési Pál 28 Antiviral agents. Dr. Perjési Pál

Practices 1 The fundamentals of reaction kinetics. The dependence of drug degradation rate on temperature and pH. Analysis of

degradation of acetylsalicylic acid. 5 Determination methods of partition coefficients. Determination of logP steroids by thin-layer chromatographic technique. 9 The structure, the configuration and the conformation of molecules. (Hyperchem) 11 The analytics of steroid hormones. TLC identification of steroid hormones. Determination of hydrocortisone content

using spectrophotometric method. 13 Identification of multi-component drug mixtures I. General principles. Pulvis antispasticus: chemical identification,

chromatographic identification, assay. 17 Identification of multi-component drug mixtures II. Determination of bases I. Pulvis chinacisalis cum vitamino C, Pulvis

somniferens. 21 Identification of multi-component drug mixtures III. Determination of bases II. Pulvis analgeticus, Tabletta Meristin. 25 Identification of multi-component drug mixtures IV. Determination of acids I. Spiritus iodosalicylatus, Spiritus

salicylatus cum resorcino. 29 Identification of multi-component drug mixtures V. Unguentum haemorrhoidale, Suppositorium analgeticum. 33 Identification of multi-component drug mixtures VI. 37 Visit at the Quality Control Laboratory of Hungaropharma Ltd 41 Vitamines. Acidum ascorbicum, Acidum folicum, Pyridoxinii ydrochloridum, Riboflavinum, Thiamini hydrochloridum.

Detremination of cyanocobalaminum by spectrophotometric and HPLC method. 45 Chemotherapeutic agents. Chinini hydrochloridum, Sulfadimidinum, Sulfaguanidinum, Sulfathiazolum,

Chloramphenicolum 49 Spectrum analysis of infrared and nuclear magnetic resonance spectrums. The nomenclature and plotting of heterocycles. 53 Summary. Repetition.

Seminars

Exam topics/questions Oral exam covering the topics of Pharmaceutical Chemistry I-IV. Before the exam each student must have a Minimum

Requirement Test the result of which must be at least 80%. Further details: www.gytsz.pte.hu

Participants Dr. Kuzma Mónika (KUMFABO.PTE)


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6 credit ▪ final exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 56 practices + 0 seminars = total of 84 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GH1 completed + OPG-GK3 completed + OPG-GT3 completed

Topic This semester solid dosage forms, theoretical introduction to granulation, tabletting and tablet coating are to be discussed. Quality control of prepared dosage forms are also discussed such as disintegration, dissolution, tablet hardness tests, etc. Aspects and work in industrial pharmacies is also mentioned during this semester.


Making up for missed classes Students must fulfil requirements stated in the Code of Studies and Examinations.


Lectures 1 Drug Delivery Systems 1. Dr. Dévay Attila 2 Drug Delivery Systems 1. Dr. Dévay Attila 3 Drug Delivery Systems 2. Dr. Dévay Attila 4 Drug Delivery Systems 2. Dr. Dévay Attila 5 Drug Delivery Systems 3. Dr. Dévay Attila 6 Drug Delivery Systems 3. Dr. Dévay Attila 7 Drug Delivery Systems 4. Dr. Dévay Attila 8 Drug Delivery Systems 4. Dr. Dévay Attila 9 Written test Dr. Dévay Attila 10 Written test Dr. Dévay Attila 11 Multiparticulate systems 1 Dr. Dévay Attila 12 Multiparticulate systems 1 Dr. Dévay Attila


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13 Multiparticulate systems 2 Dr. Dévay Attila 14 Multiparticulate systems 2 Dr. Dévay Attila 15 Multiparticulate systems 3 Dr. Dévay Attila 16 Multiparticulate systems 3 Dr. Dévay Attila 17 Development of pharmaceutical dosage forms I Dr. Dévay Attila 18 Development of pharmaceutical dosage forms I Dr. Dévay Attila 19 Written test Dr. Dévay Attila 20 Written test Dr. Dévay Attila 21 Development of pharmaceutical dosage forms II Dr. Dévay Attila 22 Development of pharmaceutical dosage forms II Dr. Dévay Attila 23 Stability of preparations Dr. Dévay Attila 24 Stability of preparations Dr. Dévay Attila 25 Quality Assurance, Quality Control, GMP Dr. Dévay Attila 26 Quality Assurance, Quality Control, GMP Dr. Dévay Attila 27 Official approval of manufactured preparations, validation, reproducibility, process control Dr. Dévay Attila 28 Official approval of manufactured preparations, validation, reproducibility, process control Dr. Dévay Attila

Practices 0 General instructions, rules and regulations on practices, solutions, nasal drops, ear drops 0 Emulsions, suspensions 0 Eye oinments, eyes drops, tea mixtures, decoctions, infusions 0 Ointments/creams/pastes/gels 0 Vaginal, rectal suppositories 0 Powders, pills, hard gelatin capsules 0 Personal assessment 1. 0 Personal assessment 2. 0 Personal assessment 3. 0 Personal assessment 4. 0 Personal assessment 5. 0 Personal assessment 6. 0 Personal assessment 7. 0 End-of-term assessment

Seminars


Participants dr. Börzsei Rita Judit (BORPAAO.PTE), Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE), Dr. Pernecker Tivadar (PETNAAO.PTE)


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OPO-KE2 PUBLIC HEALTH 2 Course director: DR. ISTVÁN KISS, full professor Department of Public Health Medicine

3 credits ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 14 practices + 0 seminars = total of 42 hours Headcount limitations (min-max.): min. 2 – no limit Prerequisites: OPO-KE1 completed

Topic The subject Public health represents the preventive side of the medicine. The subject deals with the primary, secondary, tertiary prevention of the most important diseases in our time using the conventional and the molecular/genomical epidemiology. The aim of the subject is to demonstrate the process from the health to the disease and to demonstrate the preventive possibilities at the individual and community levels.

Conditions for acceptance of the semester Oral exam


Reading material Tompa (editor): Basic Principles of Public health (ISBN: 978 963 9879 13 3) Maxcy, Rosenau, Last: Public Health and Preventive Medicine, 14th edition, Appleton and Lange (ISBN 0-8385-6185-3)

Lectures 0 Human ecology Dr. Varjas Tímea 0 Environmental disasters Dr. Varjas Tímea 0 Chemical pollutants Dr. Szabó István 0 Health effects of water pollution Dr. Szabó István 0 Health effects of soil pollution Dr. Szabó István 0 Health effects of environmental physical exposures Dr. Szabó István 0 Air pollution. Noise Dr. Szabó István 0 Occupational medicine Dr. Varjas Tímea 0 Occupational health Dr. Szabó István 0 Toxicology Dr. Szabó István 0 Industrial toxicology of organic compounds Dr. Szabó István 0 Industrial toxicology of inorganic compounds Dr. Szabó István 0 Introduction to the epidemiology of infectious diseases Dr. Szabó István 0 Pathomechansim of infection Dr. Szabó István 0 Control for nosocomial infections Dr. Szabó István 0 Molecular epidemiology of infectious diseases Dr. Szabó István 0 Laboratory diagnostics of infectious diseases Dr. Szabó István


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0 Epidemiology of airborne infections Dr. Szabó István 0 Epidemiology of parasitic infections Dr. Szabó István 0 Epidemiology of enteral diseases I. Dr. Szabó István 0 Epidemiology of enteral diseases II. Dr. Szabó István 0 Health effects of tourism, traffic and transport Dr. Szabó István 0 Epidemiology of prion diseases. Dr. Szabó István 0 Epidemiology of hepatitis Dr. Szabó István 0 Sexually transmitted diseases Dr. Szabó István 0 Epidemiology of AIDS Dr. Szabó István 0 Bioterrorism. Re-emerging and emerging infectious diseases I. Dr. Varjas Tímea 0 Bioterrorism. Re-emerging and emerging infectious diseases II. Dr. Varjas Tímea

Practices 0 Genotoxicological investigations I. 0 Genotoxicological investigations I. 0 Chemical and microbiological qualification of drinking water 0 Chemical and microbiological qualification of drinking water 0 Genotoxicological investigations II. 0 Genotoxicological investigations II. 0 Risk assessment. Chemical safety 0 Risk assessment. Chemical safety 0 Survaillance for infectious diseases. Vaccination 0 Survaillance for infectious diseases. Vaccination 0 Sterilisation, desinfection, deratisation, desinsection 0 Sterilisation, desinfection, deratisation, desinsection 0 Non-ionizing radiation and electromagnetic fields. Ionizing radiation 0 Non-ionizing radiation and electromagnetic fields. Ionizing radiation

Seminars


Participants Dr. Szabó István (SZIGABO.PTE)


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OPO-KL1 CLINICAL STUDIES 1 Course director: DR. ERIKA PINTÉR, full professor Department of Pharmacognosy

2 credits ▪ semester exam ▪ module ▪ spring semester ▪ recommended semester: 8 Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Headcount limitations (min-max.): min. 2 – max. 40 Prerequisites: OPA-BA2 completed + OPO-EL2 completed

Topic The task of the subject is the transmission of the most fundamental knowledge of the clinical studies for the pharmacy students. The curriculum covers the most important diseases focusing on their pharmacotherapy. The task of this subject is to promote the accurate knowledge of pharmacotherapy in clinical practise.

Conditions for acceptance of the semester Maximum of 15 % absence allowed

Making up for missed classes None

Reading material Lecture notes

Lectures 1 Basic principles of medication of internal diseases Dr. Cziráki Attila 2 Basic principles of medication of internal diseases Dr. Cziráki Attila 3 Cardiology Dr. Czopf László 4 Cardiology Dr. Czopf László 5 Gastroenterology Dr. Fábián György 6 Gastroenterology Dr. Fábián György 7 Hepatology Dr. Pár Alajos Imre 8 Hepatology Dr. Pár Alajos Imre 9 Nephrology Dr. Nagy Judit 10 Nephrology Dr. Nagy Judit 11 Metabolism Dr. Wittmann István 12 Hypertension Dr. Kovács Tibor 13 Survey of the endocrinological diseases Dr. Mezősi Emese 14 Survey of the endocrinological diseases Dr. Mezősi Emese 15 Pulmonology Dr. Ruzsics István 16 Pulmonology Dr. Ruzsics István 17 Hematology Dr. Nagy Ágnes


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18 Hematology Dr. Nagy Ágnes 19 Infectology Dr. Péterfi Zoltán 20 Infectology Dr. Péterfi Zoltán 21 Surgery of the esophagus and the stomach Dr. Papp András 22 Surgery of the esophagus and the stomach Dr. Papp András 23 ColOPR-octological surgery Dr. Szakály Péter 24 Transplantation Dr. Szakály Péter 25 Transplantation Dr. Szakály Péter 26 Thoracic surgery Dr. Benkő István 27 Surgery of the pancreas Dr. Kelemen Dezső 28 Surgery of the liver Dr. Papp András

Practices

Seminars

Exam topics/questions Írásbeli vizsga az előadások alapján.

Participants


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OPG-FID HERBAL MEDICINE AND HERBS IN NUTRITION Course director: DR. TAMÁS KŐSZEGI, associate professor Institute of Laboratory Medicine

2 credit ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Headcount limitations (min-max.): min. 1 – max. 30 Prerequisites: OPG-FG2 completed + OPG-GH2 completed

Topic Aims of the subject: To give an overview for the students on the biological effects of generally used herbs, drugs and herbal nutrients on the human body (beneficial and hazardous as well). To demonstrate the mode of action, indications and applications of herbal drugs in the most important disease groups by showing practical examples and case reports. To make emphasis on the interactions of herbal constituents with allopathic drugs used in modern medicine. The curriculum helps proper orientation among today’s frequent misbelieves and myths by the methods of evidence based medicine.


Making up for missed classes An absence rate of less than 25% is acceptable, no medical or other certificate is necessary. Personal contact with the tutor is possible.

Reading material Aronson J.K. (ed): Meyler’s Side Effects of Herbal Medicines. Elsevier, Amsterdam-Oxford-Tokyo, 2009 Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines. 2nd edition. Pharmaceutical Press, London-Chicago, 2002 ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products. 2nd edition. Thieme, Exeter; Stuttgart; New York,

2003 European Medicines Agency guidelines; www.ema.europa.eu

Lectures 1 Major biological effects of herbs used in the human diet Dr. Kőszegi Tamás 2 Characteristics of an optimal nutritional regime for maintenance of health in regard of herbal constituents of different

diets Dr. Kőszegi Tamás 3 Biochemical testing methods for the assessment of biological effects of herbal extracts in cellular model systems Dr. Kőszegi Tamás 4 Effects of antioxidants and other cytoprotective molecules of plant origin on cell energetics and free radical levels Dr. Kőszegi Tamás 5 Application of plant extracts and monitoring procedures of their action at the body level Dr. Kőszegi Tamás 6 Herbal formulations with immuno-modulant activity; case discussion Dr. Kőszegi Tamás 7 Application of herbal medicine based on ethnopharmacobotany and evidence based medicine Dr. Papp Nóra 8 Application of herbal medicine based on ethnopharmacobotany and evidence based medicine Dr. Papp Nóra 9 Authentic judgement of plant based dietary supplements using the conception of evidence based medicine Dr. Kőszegi Tamás 10 The problematic of plant based dietary supplements: evidences, myths and disbelieves Dr. Kőszegi Tamás 11 Role of herbal medicine in common cold (diseases of the upper respiratory tract: flue like symptoms); application of

methods based on traditions and on scientific evidences Dr. Farkas Ágnes 12 Herbal remedies in lowering blood cholesterol levels; plants with antidiabetic activity Dr. Farkas Ágnes 13 Major aspects of prevention and therapy of cardiovascular diseases (nutrition and medicinal herbs) Dr. Kőszegi Tamás


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14 Cardiovascular diseases; case discussion Dr. Kőszegi Tamás 15 Complementary therapy of chronic bone and joint diseases Dr. Kőszegi Tamás 16 Rheumatoid arthritis; case discussion Dr. Kőszegi Tamás 17 Medicinal plant drug nutrient interactions Dr. Horváth Györgyi 18 Medicinal plant drug nutrient interactions Dr. Horváth Györgyi 19 Nutritional and herbal medicine approaches in malignant diseases Dr. Kőszegi Tamás 20 Complementary therapy of malignant diseases; case discussion Dr. Kőszegi Tamás 21 Restoration of the various balances in the gastrointestinal tract by phytotherapy and microbiological therapy Dr. Kőszegi Tamás 22 Useful complementary methods in the diseases of the gastrointestinal tract; case discussion Dr. Kőszegi Tamás 23 Body care with roborant; vitamin and antioxidant containing phytotherapeutic agents and lotions Dr. Kőszegi Tamás 24 Body care with roborant; vitamin and antioxidant containing phytotherapeutic agents and lotions; critical evaluation Dr. Kőszegi Tamás

Practices

Seminars

Exam topics/questions 1. Why plants used in human nutrition may be considered to function as medicinal herbs? Give examples. 2. What types of cytoprotective factors can be found in fruits and vegetables? 3. What are the most important constituents of plant origin in the human diet for maintenance of health? 4. Give a few examples for in vitro assessment of biological effects of plant extracts in cellular models. 5. How antioxidant capacity can be measured using in vitro cellular models? How cell energetics can be characterized by

laboratory approaches? 6. Give a few clinical laboratory tests for estimation of biological effects of plant extracts at the body level (e.g. antioxidant,

antiinflammatory, antidiabetic, influencing lipid metabolism, etc). 7. What does immune modulation mean? List a few practical examples with the mention of active ingredients. 8. Plants, herbal drugs and traditional names of them. Different examples for confusing and mismatching herbal names in

phytotherapy. 9. Evaluation of traditional medicine in view of evidence based medicine (give examples). 10. What are the major rules in proper application of dietary supplements? 11. What are the contraindications in application of dietary supplements (give examples)? 12. List the most important medicinal herbs applied in the complementary therapy of common cold and name their active

ingredients. 13. Herbal drugs influencing lipid metabolism and their proper application. 14. Safe application of medicinal herbs in diabetes mellitus (active agents, complex herbal formulations). 15. Complementary therapies with indications and contraindications in cardiovascular diseases (give examples). 16. Mineral supplementation in metabolic bone diseases (including microbiological therapy). 17. Different immune modulation therapies in rheumatoid arthritis. 18. Give some examples in detail on modern drug-herbal medicine interactions with serious outcome (with reference of active

ingredients). 19. Give some examples of important food-drug interactions with reference of active ingredients. 20. List those complementary therapeutically acceptable modalities which can be interpreted by the principles of evidence based

medicine. 21. Name those complementary therapies or processes that are contraindicated in malignant diseases (active agents, ingredients). 22. Explain why restoration of function, bacterial micro flora and permeability of the gastrointestinal tract is of vital importance?


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23. Major indication of phytotherapeutical treatments in certain diseases of the gastrointestinal tract (name the active agents as well).

24. Explain the proper administration routes of vitamins, antioxidants and roborants and their indications. 25. Give description on professional compliance for formulations of external use and of cosmetics containing natural ingredients.

Participants


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OPG-GS3 PHARMACODYNAMICS 3 Course director: DR. GÁBOR PETHŐ, full professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ final exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 24 seminars = total of 48 hours Headcount limitations (min-max.): min. 5 – no limit Prerequisites: OPG-GH2 completed + OPO-GK4 completed + OPG-GT4 completed

Topic The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the endocrine system; chemotherapy of microbial diseases including antibacterial, antifungal drugs, antiviral antiprotozoal, antihelminthic agents, antiseptics and disinfectants; drugs used in chemotherapy of neoplastic diseases; immunosuppressants, immunomodulators, drug treatment of rheumatoid arthritis. Further topics are pharmacogenetics; effects of age, diet and diseases on drug action; drug interactions.




Lectures 1 Corticosteroids I Dr. Pethő Gábor 2 Corticosteroids II Dr. Pethő Gábor 3 Corticosteroids III Dr. Pethő Gábor 4 Oestrogens and anti-oestrogens Dr. Pethő Gábor 5 Progestins and anti-progestins Dr. Pethő Gábor 6 PostmenOPA-usal hormone therapy. Hormonal contraceptives Dr. Pethő Gábor 7 Androgens, anabolic steroids and anti-androgens I Dr. Pethő Gábor 8 Androgens, anabolic steroids and anti-androgens II Dr. Pethő Gábor 9 Thyroid hormones, antithyroid drugs I Dr. Simonné Dr. Hajna Zsófia Réka 10 Thyroid hormones, antithyroid drugs II Dr. Simonné Dr. Hajna Zsófia Réka 11 Hypothalamic and pituitary hormones I Dr. Pethő Gábor 12 Hypothalamic and pituitary hormones II Dr. Pethő Gábor 13 Hypothalamic and pituitary hormones III Dr. Pethő Gábor 14 Insulin, oral hypoglycaemic agents I Dr. Pethő Gábor 15 Insulin, oral hypoglycaemic agents II Dr. Pethő Gábor 16 Insulin, oral hypoglycaemic agents III. Glucagon Dr. Pethő Gábor


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17 Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteOPO-rosis I Dr. Helyes Zsuzsanna 18 Parathyroid hormone, calcitonin, vitamin D and drug treatment of osteOPO-rosis I Dr. Helyes Zsuzsanna 19 Drugs used in neoplastic diseases I Dr. Pethő Gábor 20 Drugs used in neoplastic diseases II Dr. Pethő Gábor 21 Drugs used in neoplastic diseases III Dr. Pethő Gábor 22 Drugs used in neoplastic diseases IV Dr. Pethő Gábor 23 Immunosuppressants and immunomodulators Dr. Pintér Erika 24 Drugs used to treat rheumatoid arthritis Dr. Pintér Erika

Practices

Seminars 1 Basic principles of antimicrobial chemotherapy 2 Sulphonamides and trimethOPR-im 3 Fluoroquinolones 4 Beta-lactam antibiotics I 5 Beta-lactam antibiotics II 6 Beta-lactam antibiotics III. Glycopeptide antibiotics 7 Aminoglycosides 8 Macrolide antibiotics 9 Tetracyclines, chloramphenicol 10 Linezolid, clindamycin, metronidazol 11 Antituberculotic drugs 12 Anti-leprosy drugs 13 Antifungal drugs I 14 Antifungal drugs II 15 Antiviral drugs I 16 Antiviral drugs II 17 Antiprotozoal drugs I 18 Antiprotozoal drugs II 19 Anthelminthic drugs I 20 Anthelminthic drugs II 21 Antiseptics and disinfectants I 22 Antiseptics and disinfectants II 23 Pharmacogenetics, pharmacogenomics 24 Effects of age, diet and disease on drug action. Drug interactions

Exam topics/questions 1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects

mediated by physicochemical interactions) 2. Characterisation of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy 3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs 4. Mechanisms of drug antagonisms 5. Transport of drugs across membranes 6. Absorption of drugs, oral bioavailability and presystemic elimination 7. Plasma protein binding and tissue distribution of drugs 8. Biotransformation of drugs 9. Excretion of drugs 10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability,

calculation of loading and maintenance doses 11. Drug development


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12. Harmful effects of drugs and their mechanisms 13. Factors influencing drug effects: genetic constitution, age, diet, disease 14. Drug interactions 15. Cholinergic agonists and cholinesterase inhibitors 16. Muscarinic receptor antagonists 17. Neuromuscular blocking agents. Drugs acting on autonomic ganglia 18. Agents acting on the biosynthesis, storage, release and elimination of catecholamines 19. Adrenergic receptor agonists 20. Adrenergic receptor antagonists 21. Local anaesthetics 22. Calcium channel blockers 23. Drugs acting on the renin-angiotensin-aldosterone system 24. Diuretic drugs 25. Positive inotropic and other drugs used to treat congestive heart failure 26. Antianginal drugs. Drugs that increase regional blood flow 27. Antihypertensive drugs 28. Antiarrhythmic drugs 29. Antianxiety and hypnotic drugs 30. Alcohols: pharmacology, toxicology 31. Antipsychotic drugs 32. Antidepressants 33. Central nervous system stimulants. Nootropic drugs 34. Drug treatment of neurodegenerative disorders 35. General anaesthetics 36. Antiepileptic drugs 37. Opioid analgesic drugs: morphine and codeine 38. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists 39. Non-steroidal antiinflammatory drugs: aspirin, paracetamol 40. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol 41. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants 42. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants 43. Drugs used to treat hyperlipOPR-oteinaemias 44. Drugs affecting haemostasis 45. Drugs affecting haematOPO-iesis 46. Histamine, H1 and H2 receptor antagonists 47. Serotonin, serotonin receptor agonists and antagonists 48. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine

muscle 49. Drugs used in bronchial asthma 50. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents 51. Drugs used in the treatment of peptic ulcer 52. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis 53. Laxatives, antidiarrhoeal agents, drug treatment of inflammatory bowel diseases 54. Corticosteroids 55. Oestrogens, antioestrogens, progestins, antiprogestins 56. PostmenOPA-usal hormone therapy and hormonal contraceptives 57. Androgens, anabolic steroids, antiandrogens 58. Thyroid hormones, antithyroid drugs 59. Hypothalamic and pituitary hormones 60. Insulin and oral hypoglycaemic agents. Glucagon 61. Parathyroid hormone, calcitonin and vitamin D, drugs used to treat osteOPO-rosis 62. Sulphonamides and trimethOPR-im. Fluoroquinolones 63. Beta-lactam antibiotics 64. Glycopeptide antibiotics, aminoglycosides, macrolide antibiotics 65. Tetracyclines, chloramphenicol, linezolid, clindamycin, metronidazol 66. Antituberculotic drugs. Anti-leprosy drugs


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67. Antifungal drugs 68. Antiviral drugs 69. Antiprotozoal drugs 70. Anthelminthic drugs 71. Antiseptics and disinfectants 72. Drugs used in the chemotherapy of neoplastic diseases: alkylating agents, antimetabolites 73. Drugs used in the chemotherapy of neoplastic diseases: alkaloids, antibiotics, hormonal agents, biological therapy 74. Immunosuppressants and immunomodulators. Drug treatment of rheumatoid arthritis In addition to the exam topics, an important part of the exam are questions that aim at assessing the general knowledge of the

student.

Participants Dr. Barthó Loránd (BALIAAO.PTE), Dr. Borbély Éva (BOEMAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE), Dr. Simonné Dr. Hajna Zsófia Réka (HAZMABO.PTE)


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OPG-KLF CLINICAL PHARMACOLOGY Course director: DR. ERIKA PINTÉR, full professor Department of Pharmacology and Pharmacotherapy

1 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 15 lectures + 0 practices + 0 seminars = total of 15 hours Headcount limitations (min-max.): min. 2 – max. 40 Prerequisites: OPG-GS3 parallel + OPO-KL2 parallel

Topic Via this one semester subject (15 lectures) students get acquainted with the following clinical pharmacological terms and sections: history of drug research, rational drug design, preclinical development, safety pharmacology, clinical studies (Phase I-II-III-IV), Good Clinical Practice, meta-analysis. Documentation of clinical trials. Practical aspects of clinical studies. Evidence-based medicine.

Conditions for acceptance of the semester Maximum of 15 % absence rate is allowed

Making up for missed classes Not allowed.

Reading material Lecture materials are available on the intranet. Atkinson-Abernethy-Daniels-Dedrick-Markey: Principles of Clinical Pharmacology Elsevier, 2007

Lectures 1 History of drugs Dr. Pintér Erika 2 History of drugs Dr. Pintér Erika 3 Drug design and development Dr. Pintér Erika 4 Drug design and development Dr. Pintér Erika 5 Drug design and development Dr. Pintér Erika 6 Preclinical testing Dr. Pintér Erika 7 Preclinical testing Dr. Pintér Erika 8 Safety toxicology Dr. Németi Balázs Ferenc 9 Safety toxicology Dr. Németi Balázs Ferenc 10 Human phase studies Dr. Pintér Erika 11 Hman phase studies Dr. Pintér Erika 12 Human phase studies Dr. Pintér Erika 13 GMP, GLP, GCP Dr. Helyes Zsuzsanna 14 GM, GLP, GCP Dr. Helyes Zsuzsanna 15 Documentation of the clinical studies Dr. Helyes Zsuzsanna


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Practices

Seminars

Exam topics/questions Written test based on lectures.

Participants


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OPG-PMG PROBLEMSOLVING PHARMACY Course director: DR. ERIKA PINTÉR, full professor Department of Pharmacology and Pharmacotherapy

2 credit ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 21 lectures + 0 practices + 0 seminars = total of 21 hours Headcount limitations (min-max.): min. 2 – max. 40 Prerequisites: OPG-GH2 completed + OPG-BFR completed

Topic Training for the practical aspects of the pharmacist practice. Discussions of case reports.

Conditions for acceptance of the semester Maximum of 15 % absence rate is allowed

Making up for missed classes Not allowed.

Reading material Lecture materials are available on the intranet.

Lectures 1 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Dr. Nagy Péter 2 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Dr. Nagy Péter 3 Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Dr. Nagy Péter 4 Medical treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody

stools) Dr. Nagy Péter 5 Medical treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody

stools) Dr. Nagy Péter 6 Pharmacotherapeutic problems of respiratory diseases (cough, runny nose, shortness of breath, wheezing, chest pain) Szitter István 7 Pharmaceutical problems affecting coagulation disorders (warfarin, heparin therapy, interactions, bleeding) Szitter István 8 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) Dr. Nagy Péter 9 Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) Dr. Nagy Péter 10 The specific pharmacological problems of paediatrics -1 Dr. Pintér Erika 11 The specific pharmacological problems of paediatrics -2 Dr. Pintér Erika 12 Inflammatory, allergic diseases Szitter István 13 Anxiety, depression, drug abuse Dr. Aponyi Ildikó 14 Problems of pharmacological pain management-1 Szitter István 15 Problems of pharmacological pain management-2 Szitter István 16 Problem solving in the current scope of antimicrobial therapy-1 Dr. Botz Lajos 17 Problem solving in the current scope of antimicrobial therapy-2 Dr. Botz Lajos


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18 Applications of dermatological preparations (rash, itching, scaling, dermatitis, wound care, dry skin) Dr. Fittler András Tamás 19 Arising medication problems during pregnancy and lactation Dr. Fittler András Tamás 20 Contraception, therapeutic use of drugs for treatment of genitals. Dr. Fittler András Tamás 21 Drugs used for treatment of sensory organs. Dr. Fittler András Tamás

Practices

Seminars

Exam topics/question

Written exam based on lecture materials. Lecture materials are available on the intranet. Drug therapy problems of cardiovascular diseases, (palpitations, chest pain, edema, dizziness, weakness, headache) Medical treatment of gastrointestinal disorders (anorexia, vomiting, diarrhea, constipation, abdominal pain, bloody stools) Pharmacotherapeutic problems of respiratory diseases (cough, runny nose, shortness of breath, wheezing, chest pain) Pharmaceutical problems affecting coagulation disorders (warfarin, heparin therapy, interactions, bleeding) Neurological diseases pharmacotherapy problems: (dizziness, headache, tinnitus, loss of consciousness, pain, paralysis) The specific pharmacological problems of paediatrics Inflammatory, allergic diseases Anxiety, depression, drug abuse Problems of pharmacological pain management Problem solving in the current scope of antimicrobial therapy Applications of dermatological preparations (rash, itching, scaling, dermatitis, wound care, dry skin) Arising medication problems during pregnancy and lactation Contraception, therapeutic use of drugs for treatment of genitals. Drugs used for the treatment of sensory organs.

Participants


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OPG-TOX TOXICOLOGY Course director: DR. ZOLTÁN GREGUS, full professor Department of Pharmacology and Pharmacotherapy

2 credit ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Headcount limitations (min-max.): min. 5 – max. 60 Prerequisites: OGGGS3 parallel + OPG-GK4 completed

Topic Toxicology deals with adverse health effects: including developmental, carcinogenic effects of drugs and other xenobiotics (e.g., pesticides, solvents, metal compounds, toxic gases, chemical warfare agents, mushroom- and plant-derived toxins) caused by overdose or excessive exposure. The course describes the manifestations of harmful effects, mechanisms involved in the adverse outcome, major factors influencing the development of toxic injury, diagnostics of adverse health effects, as well as their prevention and treatment. The principles and practice of safety evaluation of drugs (toxicity testing) and risk assessment of chemicals are also discussed.

Conditions for acceptance of the semester Students are requested to take two multiple choice tests during the semester and a final test at the end of the semester in the examination period. Their grades will be calculated on the basis of their performance (expressed as %) on these three tests. They can acquire 15-15% on the two tests during the study period and 70% on the final test. The cumulative score of the three tests should be at least 60% for the passing grade. The student who fails to take one or both tests during the study period can collect only 85 and 70%, respectively.

Making up for missed classes Students missing a lecture can download the teaching material from the website of Department of Pharmacology and Pharmacotherapy. Alternatively, they can use the notes of fellow students who attended the lecture, or may consult with the teacher giving the lecture.

Reading material 1. Teaching material from the website of Department of Pharmacology and Pharmacotherapy. 2. Recommended literature: a. Toxicology chapters of Pharmacology textbooks, e.g., Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12th

edition, 2011: Drug toxicity and Poisoning; Environmental Toxicology; Rang and Dale’s Pharmacology, 7th edition, 2012: Harmful effects of drugs.

b. Casarett & Doulls’ Toxicology, 8th edition, McGraw and Hill, New York, 2013. (A copy of the chapter on „Mechanisms of Toxicity” by Z. Gregus may be requested from the author.)

c. Timbrell, J.A.: Principles of Biochemical Toxicology. Fourth Edition. Taylor & Francis, Inc., London, 2008.

Lectures 1 The scope of toxicology. Human intoxications - Occurrence and classification. Causes of poisoning-related deaths. Dr. Gregus Zoltán 2 Management of poisoned patients - I. (emergency care, diagnostic procedures) Dr. Gregus Zoltán 3 Management of poisoned patients - II. (decontamination, antidotes) Dr. Gregus Zoltán 4 Management of poisoned patients - III. (enhancement of the elimination of toxicants, supportive treatment) Dr. Gregus Zoltán 5 Drug intoxications - I. Dr. Gregus Zoltán 6 Drug intoxications - II. Dr. Gregus Zoltán 7 Drug intoxications - III. Dr. Gregus Zoltán 8 Intoxication with metals - I. Mechanisms of metal toxicity. Protective mechanisms. Metal chelators. Dr. Gregus Zoltán 9 Intoxication with metals - II. Lead, mercury, cadmium. Dr. Németi Balázs Ferenc 10 Intoxication with metals - III. Arsenic, chromium, cobalt, nickel, manganese. Dr. Németi Balázs Ferenc


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11 Intoxication with pesticides - I. General properties. Insecticides: halogenated hydrocarbons. Dr. Németi Balázs Ferenc 12 Intoxication with pesticides - II. Insecticides: Organophosphates and carbamates. Herbicides. Dr. Gregus Zoltán 13 Intoxication with pesticides - III. Fungicides. Rodenticides. Fumigants. Dr. Gregus Zoltán 14 Intoxication with solvents - I. Benzol, aliphatic hydrocarbons, carbon disulfide. Dr. Gregus Zoltán 15 Intoxication with solvents - II. Alcohols, glycols, halogenated hydrocarbons. Dr. Németi Balázs Ferenc 16 Toxic gases (CO, HCN and cyanogenic compounds, H2S). Dr. Gregus Zoltán 17 Haemolytic chemicals, methaemoglobin-forming chemicals. Dr. Gregus Zoltán 18 Chemical warfare agents - I. Dr. Németi Balázs Ferenc 19 Chemical warfare agents - II. Chemical teratogenesis - I. Dr. Németi Balázs Ferenc 20 Chemical teratogenesis - II. Dr. Németi Balázs Ferenc 21 Chemical carcinogenesis - I. Dr. Gregus Zoltán 22 Chemical carcinogenesis - II. Dr. Gregus Zoltán 23 Toxicity testing and risk assessment - Principles and practices - I. Dr. Gregus Zoltán 24 Toxicity testing and risk assessment - Principles and practices - II. Dr. Gregus Zoltán

Practices

Seminars

Exam topics/questions All tests will consist of 50-70 multiple- choice questions and a few essay- questions, which are covered by the teaching materials

obtained on the website of the Department of Pharmacology and Pharmacotherapy and/or the oral lectures.

Participants


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OPG-UI4 PHARMACEUTICAL PRACTICE AND MANAGEMENT 3 Course director: DR. LAJOS BOTZ, full professor Dept. of Pharmaceutics and University Pharmacy

5 credit ▪ final exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 24 practices + 12 seminars = total of 60 hours Headcount limitations (min-max.): min. 5 – max. 50 Prerequisites: OPG-GH2 completed + OPG-GI3 completed + OPG-GT4 completed

Topic The lectures of the semester will outline the pharmaceutical supply system and professional pharmaceutical practice and care. Students will acquire computer skills in order to search for reliable pharmaceutical information. Basic knowledge of earlier theoretical studies is beneficial. The aims of the lectures in pharmaceutical studies are to broaden the pharmaceutical practice and management skills of students, and to generate interest in pharmacy as a profession.

Conditions for acceptance of the semester Mid-term examination: written. Mid-term exam: oral comprehensive exam. Acceptance criteria of the semester: attendance is required at least 75% of lectures, successful exam.


Possible following private discussion.

Reading material All presentations can be downloaded from the website of the Department: (http://aok.pte.hu/index.php?page=egyseg&egy_id=50&menu=okt_anyag&nyelv=eng). Evidence-based Pharmacy, Ed. C. Bond, Pharmaceutical Press, London, 2002. Pharmaceutical Practice, Ed. A. J. Winfield, R. M. E. Richards, Churchill Livinstone Pharmaceutical Care, Ed. C. H. Knowlton, R. P. Penna, ASHSP Hospital Pharmacy, Ed. M. Stephens, Pharmaceutical Press, London, 2006. Rosemary R. Berardi, Stefanie P. Ferreri et al.: Handbook of Nonpresciption Drugs, Sixteenth Edition, American Pharmacists

Association, 2009. Walker, Roger: Clinical Pharmacy and Therapeutics, 2011. Edzard Ernst, Simon Singh: Trick or Treatment, W. W. Norton & Company, 2008. Section IV: Nutrition and Nutritional

Supplementation, Section XI: Complementary and Alternative Medicine.

Lectures 1 Hospital pharmacy services I. Dr. Botz Lajos 2 Hospital pharmacy services II. Dr. Botz Lajos 3 Hospital pharmacy services III. Dr. Botz Lajos 4 Hospital pharmacy services IV. Dr. Botz Lajos 5 Clinical pharmacy services I. Dr. Botz Lajos 6 Clinical pharmacy services II. Dr. Botz Lajos 7 Quality Assurance I. Dr. Botz Lajos 8 Quality Assurance II. Dr. Botz Lajos 9 Individualized therapy, pharmacogenetics, therapeutic drug monitoring I. Dr. Botz Lajos 10 Individualized therapy, pharmacogenetics, therapeutic drug monitoring II. Dr. Fittler András Tamás 11 Individualized therapy, pharmacogenetics, therapeutic drug monitoring III. Dr. Fittler András Tamás


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12 Individualized therapy, pharmacogenetics, therapeutic drug monitoring IV. Dr. Fittler András Tamás 13 Clinical toxicology. 14 Pharmaceutical care of major diseases I. 15 Pharmaceutical care of major diseases II. 16 Pharmaceutical care of major diseases III. Dr. Télessy István 17 Pharmaceutical care of major diseases IV. Dr. Télessy István 18 Evaluating Clinical Trials from the aspect of EBM. 19 Fundamentals of EBM and Clinical Epidemiology I. 20 Fundamentals of EBM and Clinical Epidemiology II. 21 Evidence-based Practice. Most important internet databases I. Dr. Fittler András Tamás 22 Evidence-based Practice. Most important internet databases II. Dr. Fittler András Tamás 23 How to formulate questions, searching strategies, evaluation methods, evaluating results, conclusions. Dr. Botz Lajos 24 Patient rights in pharmacy practice. Dr. Botz Lajos

Practices 1 Good practice of dispensing non- prescription medications I. 2 Good practice of dispensing non- prescription medications II. 3 Good practice of dispensing non- prescription medications III. 4 Good practice of dispensing non- prescription medication IV. 5 Good practice of dispensing non- prescription medications V. 6 Good practice of dispensing non- prescription medications VI. 7 Good practice of dispensing non- prescription medications VII. 8 Good practice of dispensing non- prescription medications VIII. 9 Good practice of dispensing non- prescription medications IX. 10 Good practice of dispensing non- prescription medications X. 11 Good practice of dispensing non- prescription medications XI. 12 Good practice of dispensing non- prescription medications XII. 13 Practical use of EBP: Answering therapeutic questions I. 14 Practical use of EBP: Answering therapeutic questions II. 15 Practical use of EBP I. 16 Practical use of EBP II. 17 Evidence based evaluation of complementary and alternative medical practices I. 18 Evidence based evaluation of complementary and alternative medical practices II. 19 Evidence based evaluation of complementary and alternative medical practices III. 20 Evidence based evaluation of complementary and alternative medical practices IV. 21 Practice of drug dispensing, interpretation of arising problems I. 22 Practice of drug dispensing, interpretation of arising problems II. 23 Practice of drug dispensing, interpretation of arising problems III. 24 Practice of drug dispensing, interpretation of arising problems IV.

Seminars 1 Pharmaceutical care of major diseases I. 2 Pharmaceutical care of major diseases II. 3 Pharmaceutical care of major diseases III. 4 Pharmaceutical care of major diseases IV.


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5 Pharmaceutical care of major diseases V. 6 Pharmaceutical care of major diseases VI. 7 Pharmaceutical care of major diseases VII. 8 Principles of critical appraisal. 9 Interpreting results - EBM. 10 Pharmaceutical ethics I. 11 Pharmaceutical ethics II. 12 Complementary and alternative medicine.


Participants


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OPO-KL2 CLINICAL STUDIES 2 Course director: DR. ERIKA PINTÉR, full professor Department of Pharmacognosy

5 credits ▪ semester exam ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 60 lectures + 0 practices + 0 seminars = total of 60 hours Headcount limitations (min-max.): min. 2 – no limit Prerequisites: OPO-KL1 completed

Topic The task of the subject is to transmit the most fundamental knowledge pertaining to clinical studies to pharmacy students. The curriculum covers the most important diseases focusing on their pharmacotherapy. The task of this subject is to promote the accurate knowledge pharmacotherapy in the clinical practise.


Making up for missed classes None

Reading material Lecture notes

Lectures 1 Gestation time, pregnancy diagnosis, growth of the uterus during pregnancy. Uncomplicated spontaneous labor.

Disorders of pregnancy: hyperemesis gravidarum, abortion. Dr. Kovács Kálmán 2 Ultrasound examinations during pregnancy. Procedures for assessment of the status of the fetus in utero. Location of the

fetus in utero and its diagnosis. Dr. Kovács Kálmán 3 Laying, holding, rotational and integration abnormalities. Natal complications: breech, vacuum forceps, sectio Caesara,

preterm birth, preeclampsia, diabetes and pregnancy, placenta praevia, abruptio placenta, preterm rupture. Dr. Kovács Kálmán 4 Contraception. Gynecological inflammations. Sterility testing and management. Dr. Kovács Kálmán 5 Cancer screening, gynecologic cancers (cervical and endometrial cancer, ovarian cancer). Benign tumors of the uterus

(myoma). Dr. Kovács Kálmán 6 Growth and development during childhood. Dr. Decsi Tamás Dr. Györgyi Csábi 7 Infant nutrition. Dr. Decsi Tamás Dr. Györgyi Csábi 8 The bacterial infections in pediatric care practice. Dr. Decsi Tamás Dr. Györgyi Csábi 9 Exsiccatio, fluid replacement, oral rehydration. Antifebrile therapy, treatment of convulsion. Dr. Decsi Tamás Dr. Györgyi Csábi 10 Neurological disease symptoms, peripheral and central nervous system disorders. Dr. Pál Endre 11 Stroke. Dr. Pál Endre 12 Encephalitis and meningitis, intracranial and spinal tumors. Dr. Pál Endre 13 Multiple sclerosis, Parkinson’s disease, epilepsy. Dr. Pál Endre 14 Peripheral nervous system diseases, myOPA-thies. Dr. Pál Endre 15 Examination of psychiatric patient. Dr. Tényi Tamás 16 Organic mental disorders. Dr. Tényi Tamás


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17 Endogenous psychoses. Dr. Tényi Tamás 18 Non-psychotic psychiatric disorders. Psychiatric therapies. Dr. Tényi Tamás 19 Ear, nose, laryngology. The outer and middle ear. Dr. Bauer Miklós 20 The inner ear. Audiological and vestibular basics. Dr. Bauer Miklós 21 The nose. Dr. Bauer Miklós 22 The pharynx. Dr. Bauer Miklós 23 The larynx, trachea, esophagus and neck. Dr. Bauer Miklós 24 Basics of preventive dentistry, pediatric dentistry. Dr. Szántó Ildikó 25 Oral surgery treatments, pain relief. Dr. Szántó Ildikó 26 Restorative dental treatments. Dr. Szántó Ildikó 27 Basics of prosthodontics. Dr. Szántó Ildikó 28 Dental development, orthodontic anomalies, drug-induced dental lesions. Dr. Szántó Ildikó 29 Orthopedic examination possibilities, orthopedic screenings, pediatric orthopedic disorders. Dr. Tunyogi Csapó Miklós 30 Large joint diseases and their medical and surgical management Dr. Tunyogi Csapó Miklós 31 Spinal diseases and their conservative and surgical treatment. Dr. Tunyogi Csapó Miklós 32 Joint injuries and their pharmacological and surgical treatment. Dr. Tunyogi Csapó Miklós 33 Orthopedic surgery perioperative complications, prevention, and treatment. Dr. Tunyogi Csapó Miklós 34 Drugs relating voiding and storage of urine, medical treatment of BPH. Dr. Pytel Ákos 35 Medical treatment of uro-oncological diseases. Dr. Beöthe Tamás 36 Medical treatment of erectile dysfunction. Dr. Szántó Árpád 37 Medical aids in urological practice. Dr. Villányi Kinga 38 Urologic clinics of stone diseases and drugs. Dr. Székely József 39 The structure of skin, essential phenomena. Dr. Péter Iván 40 Infectious skin disease, pyoderma, bacterial, viral and fungal diseases. Dr. Péter Iván 41 STD diseases and sexual health care. Dr. Péter Iván 42 Dermatological tumors. Immunpathological disorders in dermatology. Dr. Péter Iván 43 Eye examination of the patient. (The functional anatomy of the organ of vision, functional and morphological methods of

analysis.) Dr. Nagy Ágnes


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44 Chronic eye diseases (glaucoma, cataracts, age-related macular degeneration, symptomatology, basic examinations, interpretation of findings, therapy).

Dr. Nagy Ágnes 45 Acute ocular diseases. (Symptomatology, basic examinations, interpretation of findings, therapy). Dr. Nagy Ágnes 46 Childhood eye diseases. Ocular symptoms of general disorders. Neuroophthalmology. Dr. Nagy Ágnes 47 Traumatology in ophthalmology and intraocular tumors. Dr. Nagy Ágnes 48 Treatment of spondylarthritis. Treatment of gout. Treatment of infection-triggered arthritis. Dr. Kumánovics Gábor 49 Non-biological and biological base therapeutic drugs in rheumatoid arthritis. Dr. Kumánovics Gábor 50 Rules of the utilization of non steroidal antiinflammatory drugs in rheumatology and clinical immunology. Management

of acute and chronical pain in rheumatology. Dr. Hóbor Renáta 51 Pharmacological treatment of osteoporosis. Dr. Hóbor Renáta 52 Treatment with corticosteroids and cytostatic agents in autoimmune diseases. Dr. Czirják László 53 The investigation of patients with cancer, the TNM system, most defining aspects of oncology and drug therapy and

onkoteam decision. Dr. Mangel László 54 The clinical implications of chemotherapy treatments. Dr. Mangel László 55 Modern targeted biological therapies. Dr. Varga Zsuzsanna 56 The principles and practice of the radio-chemotherapy and basics of hormone therapy. Dr. Varga Zsuzsanna 57 The practice of supportive therapy in medicine. Dr. Mangel László Dr. Erika Kövér 58 Specificity of General Practice, a holistic approach to enforcement. Dr. Bán Ildikó 59 Physician-pharmacist relationship. Team work. Role-playing. Dr. Végh Mária Dr. Ágnes Csikós 60 GP office and staff. Pharmacist-patient relationship. Dr. Végh Mária

Practices

Seminars

Exam topics/questions Written exam based on the lecture material

Participants


84

OPO-KLV CLINICAL LABORATORY INVESTIGATIONS Course director: DR. TAMÁS KŐSZEGI, professor Department of Laboratory Medicine

2 credits ▪ midsemester grade ▪ module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 24 lectures + 0 practices + 0 seminars = total of 24 hours Headcount limitations (min-max.): min. 1 – no limit Prerequisites: OPO-KL2 parallel + OPO-IMM completed + OPO-KOT completed

Topic Clinical Laboratory Investigations is a subject based on a solid knowledge in chemistry, biochemistry and physiology. It is a practical guide for comprehending and interpreting a wide variety of modern laboratory tests because it reveals the molecular basis of them. The subject includes classic chemical and biochemical methods, immunochemistry, hematology, blood coagulation, toxicology and molecular biology. The major methodological aspects and applications are discussed during the lectures.

Conditions for acceptance of the semester During the semester two written multiple choice tests should be completed. Attendance of the lectures is obligatory. An absence rate less than 25% of the lectures is only acceptable. The semester may not be accepted and credit points may not be given should absences exceed more than 25% and/or when the two written multiple choice tests are not passed successfully.

Making up for missed classes An absence-rate of less than 25% is acceptable, no medical or other certificate is necessary.

Reading material W.J. Marshall, S.K. Bangert: Clinical Chemistry, 5th ed., Mosby Co, 2004, ISBN 0723433283 G.J. Beckett, S.W. Walker, P. Rae, P. Ashby: Lecture Notes on Clinical Biochemistry, 7th ed., Blackwell Co., 2005 W.J. Marshall, S.K. Bangert: Clinical Chemistry 6th ed., Mosby Co, 2008 ISBN 9780723434559

Lectures 1 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. Different

factors influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches). Dr. Kőszegi Tamás 2 Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. Different

factors influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches). Dr. Kőszegi Tamás 3 Different laboratory approaches in water and electrolyte disorders. Internal and external quality controls. Dr. Kőszegi Tamás 4 Different laboratory approaches in water and electrolyte disorders. Internal and external quality controls. Dr. Kőszegi Tamás 5 Analysis of plasma proteins. Separation techniques and basis of immunochemical methods. Dr. Kőszegi Tamás 6 Analysis of plasma proteins. Separation techniques and basis of immunochemical methods. Dr. Kőszegi Tamás 7 Analysis of plasma enzymes. Routes of release of enzymes into the extracellular space. Enzymes as tissue markers. Dr. Kőszegi Tamás 8 Analysis of plasma enzymes. Routes of release of enzymes into the extracellular space. Enzymes as tissue markers. Dr. Kőszegi Tamás 9 Carbohydrate metabolism and laboratory tests in endocrine diseases. Dr. Kőszegi Tamás 10 Carbohydrate metabolism and laboratory tests in endocrine diseases. Dr. Kőszegi Tamás 11 Laboratory diagnostics of cardiac and skeletal muscle diseases. Inherited and acquired disorders. Importance of the half-

life of tested parameters. Dr. Kőszegi Tamás 12 Laboratory diagnostics of cardiac and skeletal muscle diseases. Inherited and acquired disorders. Importance of the half-

life of tested parameters. Dr. Kőszegi Tamás


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13 Iron, porphyrin and hemoglobin metabolism. Automated immunochemical measurements. Dr. Kőszegi Tamás 14 Iron, porphyrin and hemoglobin metabolism. Automated immunochemical measurements. Dr. Kőszegi Tamás 15 Disorders of lipid metabolism. Automated hematological analyses. Dr. Kőszegi Tamás 16 Disorders of lipid metabolism. Automated hematological analyses. Dr. Kőszegi Tamás 17 Acid-base balance. Methods and interpretation of test results. Dr. Kőszegi Tamás 18 Acid-base balance. Methods and interpretation of test results. Dr. Kőszegi Tamás 19 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases. Dr. Kőszegi Tamás 20 Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases. Dr. Kőszegi Tamás 21 Laboratory tests in kidney diseases. Tumors and tumor markers. Dr. Kőszegi Tamás 22 Laboratory tests in kidney diseases. Tumors and tumor markers. Dr. Kőszegi Tamás 23 Different approaches in liver and gastrointestinal diseases. Basic methods in investigation of disorders in hemostasis. Dr. Kőszegi Tamás 24 Different approaches in liver and gastrointestinal diseases. Basic methods in investigation of disorders in hemostasis. Dr. Kőszegi Tamás

Practices

Seminars

Exam topics/questions In every new semester new multiple choice questions are to be worked out.

Participants


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OPS-SG3 PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 1 Course director: DR. KLÁRA MAYER, associate professor Department of Pharmacotechnology

4 credits ▪ midsemester grade ▪ final/rotational (year) module ▪ autumn semester ▪ recommended semester: 9 Number of hours/semester: 0 lectures + 320 practices + 0 seminars = total of 320 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPG-GH1 completed + OPG-GI2 completed + OPR-SG2 completed

Topic The aim of the first part of the final year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing the aspects of pharmaceutical care, economy and preparing magistral medicines in the pharmacy.

Conditions for acceptance of the semester A brief daily report must be completed during the practice and presented. Tutor pharmacist and chief pharmacist must evaluate students work and confirm the pharmacy practice with their signature. Students must work daily 8 hours during two month of practice.

Making up for missed classes During the 6 months practice only 5 days are allowed to be missed and must be confirmed by a physician. More days of missing must be supplemented.

Reading material European Pharmacopoeia International pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices 1 Students should prepare at least one magistral preparation every day concerning the work of the assistant under the

supervision of the tutor pharmacist 2 Elaborating under supervision 3 Impleation of pharmaceutical ingredients, writing log of impleation 4 Studying and preparing medicines of the Hungarian National Formulary (FoNo VII.) 5 Studying and preparing galenic formulations 6 Aseptic work in pharmacy 7 Control of medicines regarding the incoming ingredients, medicines, medical aids 8 Examination of elaborated medicines (e.g.: Alcohol 70%, Syrups) 9 Examination of incoming ingredients 10 Nomenclature of ingredients 11 Pharmaceutical economy, ordering medicines 12 Treatment of drugs and ingredients of increased control 13 Treatment of waste medicines 14 Treating shift of prices of medicines 15 Daily, weekly, monthly account, monthly reports for health insurance company 16 Re-control of prescriptions 17 Expenditure of medicine 18 Errors and omissions on prescription 19 Veterinary prescriptions 20 HomeOPA-thy in pharmacy 21 Over the counter drugs, their expenditure 22 Directives of the pharmacy 23 Studying pharmaceutical literature 24 Federal laws and bulletins of the pharmaceutical profession 25 Studying the pharmaceutical software for expenditure

Seminars

Exam topics/questions Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.


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OPS-SG4 PROFESSIONAL PRACTICE BEFORE STATE EXAMINATION 2 Course director: DR. KLÁRA MAYER, associate professor Department of Pharmacotechnology

14 credits ▪ midsemester grade ▪ final/rotational (year) module ▪ spring semester ▪ recommended semester: 10 Number of hours/semester: 0 lectures + 640 practices + 0 seminars = total of 640 hours Headcount limitations (min-max.): min. 1 – max. 50 Prerequisites: OPGGS3 completed + OPG-UI4 completed + OPG-GT4 completed

Topic The aim of the first part of the final year is to expand the knowledge and approach of student with practice oriented pharmaceutics, knowing the aspects of pharmaceutical care, economy and preparing medicines both in the public pharmacy (3 months)and in clinical/hospital (1 month)pharmacies. This course is expanded with practice in clinical/hospital pharmacies in order to learn the tasks and connections of the pharmacy with other wards of the hospital.

Conditions for acceptance of the semester Brief daily report must be done during the practice which has to be presented. Tutor pharmacist and chief pharmacist has to evaluate students work and confirm the pharmacy practice with their signature. Student must work daily 8 hours during two month of practice.

Making up for missed classes During the 6 months practice only 5 days are allowed to miss confirmed by a physician. More days of missing must be supplemented

Reading material European Pharmacopoeia International pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII) Compendium

Lectures

Practices 1 PUBLIC PHARMACY

Students should prepare at least one magistral preparation every day concerning the work of the assistant under the supervision of the tutor pharmacist

Elaborating under supervision

Impleation of pharmaceutical ingredients, writing log of impleation

Studying and preparing medicines of the Hungarian National Formulary (FoNo VII.)

Studying and preparing galenic formulations

Aseptic work in pharmacy

Control of medicines regarding the incoming ingredients, medicines, medical aids

Examination of incoming ingredients

Examination of elaborated medicines (e.g.: Alcohol 70%, Sirup. simplex)

Nomenclature of ingredients

Pharmaceutical economy, ordering medicines

Treatment of drugs and ingredients of increased control

Treatment of waste medicines

Treating shift of prices of medicines

Daily, weekly, monthly account, monthly reports for health insurance company

Re-control of prescriptions

Expenditure of medicine

Errors and omissions on prescription

Veterinary prescriptions

HomeOPA-thy in pharmacy

Over the counter drugs, their expenditure

Directives of the pharmacy

Studying pharmaceutical literature

Federal laws and bulletins of the pharmaceutical profession

Studying the pharmaceutical software for expenditure


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27 CLINICAL /HOSPITAL PHARMACY

Knowing the structure of hospital/clinic

Studying the relationship between the pharmacy and other wards

Controlling role of the pharmacy regarding drug utilization and storage of different wards

Federal laws affecting clinical pharmacy practice

Preparing drugs specified for clinical pharmacies under the supervision of the tutor pharmacist

Participating in works on different divisions of the pharmacy (labelling, packaging, etc.)

Knowing and operating with special appliances on different divisions (galenic division, parenteral division) of the pharmacy under the supervision of the tutor pharmacist

Knowing basic galenic preparations of the pharmacy containing knowledge of preparation of infusions, peritoneal dialysis solutions; knowing the conditions for preparations, analytical and microbiological control methods and storage

Preparation of complex infusions (cytostatic infusions, parenteral nutrition infusions)

Knowing and preparation of special magistral formulas, comparing with official formulas of FoNo VII. or Manuale Pharmaceuticum

Recognizing and repairing incompatibilities

Participating in economical tasks of the pharmacy

Studying drugs, medical aids, nutritions, diagnostics, x-ray contrast materials stored in pharmacy

Participating in ordering of drugs on-line and off-line

Studying relationship with pharmaceutical manufacturers and distributors

Studying drug order from foreign countries

Treatment of drugs and ingredients of increased control

Studying participation of the pharmacy in the therapy

Knowing the intelligence service of the pharmacy

Studying role and function of Board of Pharmaceutical Therapy, knowing its protocols

Studying drug development clinical trials, knowing the documentation, federal laws regarding clinical trials

Studying the relationship between the pharmacy and the clinical laboratory

Knowing reagents applied in diagnostics including preparation

Treatment of biological samples, basic clinical examinations, normal levels

Knowing other special tasks of the pharmacy (e.g.: measurement of drug concentration in plasma)

Studying pharmaceutical literature

Knowing basic databases used in clinical pharmacy

Knowing the system of quality assurance

Knowing the quality assurance of the hospital emphasizing the regulations regarding the pharmacy

Seminars

Exam topics/questions Knowledge acquired is evaluated based on reports made during pharmacy practice and the evaluation of the tutor/chief pharmacist.


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