June 2019 Proprietary Information. Restricted Access – Do not disseminate or copy without approval. © 2008-2019 Magellan Rx Management. All Rights Reserved.

Cough and Cold Therapeutic Class Review (TCR)

June 12, 2019

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The materials contained herein represent the opinions of the collective authors and editors and should not be construed to be the official representation of any professional organization or group, any state Pharmacy and Therapeutics committee, any state Medicaid Agency, or any other clinical committee. This material is not intended to be relied upon as medical advice for specific medical cases and nothing contained herein should be relied upon by any patient, medical professional or layperson seeking information about a specific course of treatment for a specific medical condition. All readers of this material are responsible for independently obtaining medical advice and guidance from their own physician and/or other medical professional in regard to the best course of treatment for their specific medical condition. This publication, inclusive of all forms contained herein, is intended to be educational in nature and is intended to be used for informational purposes only. Send comments and suggestions to PSTCREditor@magellanhealth.com.

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FDA-APPROVED INDICATIONS1

Cough and cold formulations are available for use in the treatment of the signs and symptoms of the common cold, sinusitis, allergies, and cough. They come in various combinations from simple cold formulations, narcotic cough and cold formulations, as well as non-narcotic cough and cold formulations. The cold formulations are available as prescription generics which are combined in one of the following manners with several of the available ingredients: antihistamine-only, antihistamine-decongestant, decongestant-expectorant, and expectorant-only. There are many narcotic cough and cold formulations available as prescription generics which are combined in one of the following manners with several of the available ingredients: antitussive-anticholinergic, antitussive-antihistamine-decongestant, antitussive-decongestant-expectorant, and antitussive-expectorant. Lastly, there are many non-narcotic cough and cold formulations that are available as prescription generics which are combined in one of the following manners with several of the available ingredients: antitussive-antihistamine, antitussive-antihistamine-decongestant, antitussive-antihistamine-decongestant-expectorant, antitussive-decongestant, antitussive-decongestant-expectorant, and antitussive-expectorant.

Current products are listed in Appendix A.

OVERVIEW

The common cold is a viral illness that affects persons of all ages prompting frequent use of over-the-counter (OTC) and prescription medications and alternative remedies.2 Adults in the United States (US) experience 2 to 3 colds per year and incidence in children is even greater.3 At least 200 identified viruses are capable of causing the common cold. The viruses often implicated include rhinoviruses, coronaviruses, parainfluenza viruses, respiratory syncytial virus, adenoviruses, and enteroviruses.

Although histologic effects on the nasal epithelium may vary, any of the viruses can cause vasodilation and hypersecretion, leading to the common cold syndrome, which includes nasal congestion, nasal discharge, postnasal drip, throat clearing, sneezing, and cough.

Acute cough has been characterized as a cough lasting 3 weeks or less, sub-acute cough lasts 3 to 8 weeks, and chronic cough lasts over 8 weeks.4,5 Causes of acute cough include the common cold or other respiratory tract infection, and allergic rhinitis. Subacute cough remains after the initial cold or respiratory infection is over. Causes of chronic cough include asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). Cough may also be associated with factors such as gastroesophageal reflux disease (GERD), medication side effects, pulmonary embolism, smoking, and lung cancer; cough due to these conditions will not be addressed in this class review.

Common cold, or upper respiratory tract infection is the third most common reasons for physician visits, with cough being a common presenting symptom.6 In 2017 American College of Chest Physicians (ACCP) updated their clinical practice guidelines on the cough. The ACCP suggests against use of OTC cough and cold medicines and nonsteroidal anti-inflammatory drugs (NSAIDs) in adults and pediatric patients until these products have demonstrated that they decrease cough severity or time to cough resolution. In pediatric patients (≤ 18 years of age), ACCP suggests use of honey in patients to relieve cough over diphenhydramine, or no treatment, but does not recommend honey over dextromethorphan. Notably, honey should not be used in infants less than 1 year of age and children less than 2 years of age should not be given dextromethorphan for cough. Codeine-containing medications should be avoided in pediatrics due to the potential for serious adverse effects.7

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There are a variety of prescription and OTC cough and cold combination products. The focus of this review will be on the prescription products with emphasis on the component ingredients. There are also numerous generic products available.

PHARMACOLOGY

Drug Type Mechanism of Action Examples Anticholinergics Competitively blocks the muscarinic receptors, primarily M2 and M3,

and causes the drying effect on mucus membranes. homatropine, methscopolamine, scopolamine

Antihistamines (first generation)

Competitively antagonize the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle; Blockade of H1-receptors also suppresses the formation of edema, flare, and pruritus that result from histaminic activity; H1-antagonists also possess anticholinergic properties in varying degrees

brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine, dexbrompheniramine, dexchlorpheniramine, diphenhydramine, doxylamine, hydroxyzine, promethazine, pyrilamine, triprolidine

Antitussives (opiate)

Directly act on receptors in the cough center of the medulla; These agents may also have a drying effect on the respiratory tract and increases the viscosity of bronchial secretions; Cough suppression can be achieved at lower doses than those required to produce analgesia; The most significant adverse effect associated with opiate agonist use is respiratory depression which results from a decreased sensitivity to carbon dioxide in the brainstem; Opiates cause generalized central nervous system (CNS) depression; Additive sedative effects are possible with other agents that can lead to CNS depression

codeine, dihydrocodeine, hydrocodone

Antitussives (non-opiate)

Dextromethorphan is a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors in the brain and spinal cord; It acts on the cough center in the medulla to raise the threshold for coughing by decreasing the excitability of the cough center; It is the d-isomer of levorphanol but has none of the analgesic, respiratory depressive, or sedative effects associated with opiate agonists Carbetapentane and chlophedianol appear to work directly on the cough center of the medulla, thereby suppressing the cough reflex; Carbetapentane has atropine-like and anesthetic actions, producing a drying effect of respiratory mucus secretion; In addition, it possesses mild bronchodilatory actions, and does not affect respiratory volume

carbetapentane, chlophedianol, dextromethorphan

Decongestants Phenylephrine possesses both direct and indirect sympathomimetic effects, primarily as a post-synaptic alpha-adrenergic agonist, producing potent vasoconstriction. An indirect effect due to the release of norepinephrine plays a small role in the overall action of phenylephrine; Constriction of blood vessels leads to reduced blood flow to the nose, decreased amount of blood in the sinusoid vessels, and decreased mucosal edema, which relieves nasal congestion; Phenylephrine does not affect the beta receptors in the heart or lungs Pseudoephedrine is a sympathomimetic amine that causes the release of norepinephrine, leading to vasoconstriction and a decrease in nasal and sinus congestion

phenylephrine, pseudoephedrine*

Expectorants Loosens and thins sputum and bronchial secretions to ease expectoration

guaifenesin

* Many products containing pseudoephedrine have been reformulated due to increased regulatory restrictions on the sale and distribution of the drug, likely due to its notable use as a precursor in the illicit synthesis of methamphetamine.

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PHARMACOKINETICS

Due to the various product formulations and varying component ingredients in the cough and cold products, the specific product information should be consulted to evaluate pharmacokinetics.

CONTRAINDICATIONS/WARNINGS

In January 2007, the Centers for Disease Control and Prevention (CDC) warned caregivers and healthcare providers of the risk for serious injury or fatal overdose from the administration of cough and cold products to children and infants less than 2 years of age.8 This warning followed an investigation of the deaths of 3 infants less than 6 months of age that were attributed to the inadvertent inappropriate use of these products. The symptoms preceding these deaths have not been clearly defined, and there is a lack of conclusive data describing the exact cause of death. The report estimated that 1,519 children less than 2 years of age were treated in emergency departments during 2004 and 2005 for adverse events related to cough and cold medications.

In October 2007, the Food and Drug Administration (FDA) Nonprescription Drug Advisory Committee and the Pediatric Advisory Committee recommended that nonprescription cough and cold products containing pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, brompheniramine, phenylephrine, clemastine, or guaifenesin not be used in children less than 6 years of age.9 In January 2008, the FDA issued a Public Health Advisory recommending that OTC cough and cold products not be used in infants and children less than 2 years old.10,11,12 The FDA recommends that if parents and caregivers use cough and cold products in children older than 2 years, labels should be read carefully, caution should be used when administering multiple products, and only measuring devices specifically designed for use with medications should be used. While some combination cough/cold products containing these ingredients are available by prescription only and are not necessarily under scrutiny by the FDA, clinicians should thoroughly assess each patient’s use of similar products, both prescription and nonprescription, to avoid duplication of therapy and the potential for inadvertent overdose.

In January 2008, a FDA panel recommended that nonprescription cold medicines should not be given to children under 2 years old due to the risk of serious and potentially life-threatening adverse reactions. Research has shown that these products offer little to no benefit in this patient population, and may increase the risk of poisoning.13 In October 2008, manufacturers of cough and cold products voluntarily modified their labels to increase the age recommended warnings for use in children and infants to less than 4 years of age versus the previous warning in children and infants less than 2 years of age, making this a more stringent warning than the FDA advisory.14,15 Manufacturers also introduced child-resistant packaging and new measuring devices for use with the products. Alternatives for this patient population include acetaminophen or ibuprofen which can be used to minimize pain and fever, and saline nasal sprays which can be used to clear nasal passages. A cool mist vaporizer is also an option for congestion.16

A retrospective review of OTC cough and cold medication ingestions reported to US poison centers between 2000 and 2010 revealed that unintentional ingestions of these medications decreased by 33.4% and therapeutic errors by 46%.17 Healthcare facility referrals declined for unintentional ingestions (28.9% in patients less than 2 years of age, 19.9% in ages 2 to 5 years, [p<0.0001]) and therapeutic errors (59.2% in children less than 2 years of age; p<0.0001). In addition, among children less than 2 years of age, emergency department (ED) visits related to cough and cold medication decreased from 4.1% of all adverse drug event ED visits before the 2007 manufacture’s voluntary market withdrawal of infant cough

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and cold medications to 2.4% afterward. Similarly, among children aged 2 to 3 years, ED visits related to cough and cold medication adverse drug events decreased from 9.5% of all adverse drug event ED visits before the labeling revision announcement to 6.5% afterward.18

In 2015, the FDA announced they are investigating possible risks of using codeine-containing medications to treat cough and cold symptoms in patients less than 18 years old due to the risk of serious side effects, including slowed or difficult breathing.19 Due to the serious risks associated with the use of codeine-containing products in children, the FDA issued a drug safety communication regarding the use of codeine on April 20, 2017.20 Product labeling for all codeine-containing products was updated to add a contraindication alerting that codeine should not be used to treat pain or cough in children younger than 12 years. A new warning was added to recommend against the use of codeine-containing products in adolescents between 12 and 18 years who are obese or have conditions such as obstructive sleep apnea or severe lung disease, which may increase the risk of serious breathing problems. Additionally, the warning regarding breastfeeding was strengthened to state that breastfeeding is not recommended with use of codeine-containing products due to the risk of serious adverse reactions in breastfed infants, which can include excess sleepiness, difficulty breastfeeding, or serious breathing problems that could result in death. In January 2018, the FDA issued an additional drug safety communication for prescription opioid cough and cold products limiting their use to adults (aged 18 years and older) due to the risks of these medicines outweighing their benefits in children younger than 18 years old.21 The FDA also required the addition of safety information about the risks of misuse, abuse, addiction, overdose, death, and slowed or difficult breathing to the Boxed Warnings for prescription cough and cold medicines containing codeine or hydrocodone.

Some pyrilamine products may contain phenylalanine. These products should not be used in patients with phenylketonuria (PKU).

DRUG INTERACTIONS22

Drug Type

An

tich

olin

erg

ics

An

tih

ista

min

es

An

titu

ssiv

es

(op

iate

)

An

titu

ssiv

es

(no

n-o

pia

te)

De

con

gest

ants

Exp

ect

ora

nts

CNS depressants (e.g., alcohol, sedatives, anxiolytics, etc.)

-- -- -- -- --

Monoamine oxidase inhibitors (MAOIs) -- -- -- -- --

Tricyclic antidepressants -- -- -- --

Alpha blockers -- -- -- -- --

Beta blockers -- -- -- -- --

Centrally acting antihypertensives -- -- -- -- --

Antidiabetic agents -- -- -- -- --

Ototoxic medications (e.g., aminoglycosides)

-- -- -- --

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Concurrent administration of methscopolamine nitrate with either sildenafil or vardenafil has been shown to potentiate hypotension due to the nitrate. Therefore, the concurrent use of sildenafil or vardenafil with products containing methscopolamine nitrate is not recommended.

ADVERSE EFFECTS23,24

Drug Type

An

tich

olin

ergi

cs

An

tih

ista

min

es

An

titu

ssiv

es

(op

iate

)

An

titu

ssiv

es

(no

n-o

pia

te)

De

con

gest

ants

Exp

ecto

ran

ts

Drowsiness

Xerostomia -- -- --

Nausea --

Tachycardia / Palpitations -- -- -- --

CNS depression --

Respiratory depression -- -- --

= Reported

Adverse effects are reported above as a class effect due to the multiple ingredients contained in the products. Adverse effects have been taken from package inserts or other reliable databases and are not meant to be comparative or all inclusive.

SPECIAL POPULATIONS25,26

Pediatrics

Many of the products in this category are approved for use in children as young as 2 years of age. Use of prescription opioid cough and cold products are limited to adult patients aged 18 years and older due to the risks of these medicines outweighing their benefits in children younger than 18 years of age. Please consult the individual prescribing information for specific product information.

Pregnancy

Pregnancy category depends upon the component ingredients. Many are Pregnancy Category C, but consult the individual package inserts for specific product information.

Renal Impairment

Dosage adjustment may be warranted; however, specific guidelines in renal impairment are not available. Consult the individual package inserts for additional information.

Hepatic Impairment

Specific guidelines for dosage adjustments in patients with hepatic impairment are not available. Lower doses may be warranted due to metabolism of any one of the ingredients in a given product.

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Geriatrics

The elderly are more susceptible to the anticholinergic effects of antihistamines. Reduced initial dosages may be needed.

DOSAGES27,28

Drug (Products containing drug)

Maximum Recommended Daily Dose Availability

Adult Child

Anticholinergics

homatropine 9 mg

Ages: 6 to 12 years:

4.5 mg

Tablet and syrup formulations

methscopolamine 12.5 mg

Safe and effective use has not been established in children

Tablet, chewable tablet, and syrup formulations

scopolamine 2.4 mg

Safe and effective use has not been established in children

Tablet and solution formulations

Antihistamines

brompheniramine

48 mg

Ages: 6 to 11 years: 24 mg 2 to 5 years: 12 mg 1 to 2 years: 6 mg

6 to 12 months: 3 mg 3 to 6 months: 2 mg 1 to 3 months: 1 mg

Tablet, capsule, solution, syrup, and suspension

formulations

carbinoxamine

32 mg

Ages: > 6 years: 24 mg

3 to 6 years: 16 mg 2 to 3 years: 8 mg

Solution, suspension, syrup formulations

chlorpheniramine

24 mg Ages:

≥ 6 years: 12 mg 2 to 5 years: 4 mg

Suspensions, solutions, extended-release tablets,

chewable tablets

Extended release formulations are not recommended for children under age 6 years

clemastine

2 mg

Ages: ≥ 12 years: 2 mg

< 12 years: safe and effective use has not been established

Tablet and caplet formulations

cyproheptadine 32 mg

Ages: 7 to 14 years: 16 mg 2 to 6 years: 12 mg

Syrup and tablet formulations

dexbrompheniramine

12 mg

Ages: ≥ 12 years: 12 mg

< 12 years: safe and effective use has not been established

Tablets, extended-release tablets, and syrup

formulations

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Dosages (continued)

Drug (Products containing drug)

Maximum Recommended Daily Dose Availability

Adult Child

Antihistamines (continued)

dexchlorpheniramine

No maximum dosing information

available

Available for use in patients ages ≥ 2

Extended release tablet and oral solution formulations

Extended release tablets are not recommended for use in children 3 to 5 years of age

diphenhydramine 300 mg

Ages: ≥ 6 years: 300 mg

Tablet and suspension formulations

doxylamine 25 mg

Ages: ≥ 12 years: 25 mg

Suspension and chewable tablet formulations

hydroxyzine

400 mg

Ages: ≥ 6 years: 100 mg < 6 years: 50 mg

Infants: safety and efficacy have not been established

Tablets, capsules, and solution formulations

promethazine

100 mg

Ages: Adolescents: 100 mg

≥ 2 years: lesser of 25 mg/dose or

0.5 mg/pound/dose

Tablets and syrup formulations

pyrilamine No maximum dosing information

available

Available for use in patients ages ≥ 2 years

Tablet, syrup, suspension, and chewable tablet formulations

triprolidine

10 mg

Ages: 6 to 11 years: 5 mg

4 to 5 years: 3.75 mg 2 to 3 years: 2.5 mg

4 months to 1 year: 1.25 mg

Tablet, solution, and suspension formulations

Antitussives (opiate)

codeine 360 mg

Ages: Use limited to patients > 18

years

Tablet, capsule, syrup, and solution formulations

dihydrocodeine 90 mg

Use limited to patients > 18 years

Syrup and solution formulations

hydrocodone 30 mg (as an antitussive)

Use limited to patients > 18 years

Capsule and syrup formulations

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Dosages (continued)

Drug (Products containing drug)

Maximum Recommended Daily Dose Availability

Adult Child

Antitussives (non-opiate)

carbetapentane

240 mg

Ages: 6 to 12 years: 120 mg

4 to 5 years: 30 mg 2 to 3 years: 15 mg

Tablets, capsules, extended-release capsules, and

suspension formulations

chlophedianol 100 mg

Ages: 2 to 12 years: 50 mg

Solution formulations

dextromethorphan 120 mg

Ages: 6 to 11 years: 60 mg 2 to 5 years: 30 mg

Tablet, chewable tablet, suspension, and solution

formulations

Decongestants

phenylephrine 60 mg

Ages: 6 to 12 years: 30 mg 2 to 5 years: 15 mg

Tablet, chewable tablet, solution, and syrup

formulations

pseudoephedrine 240 mg

Ages: 6 to 11 years: 120 mg

2 to 5 years: 60 mg

Chewable tablet, capsule, solution, suspension, and

syrup formulations

Expectorants

guaifenesin

2,400 mg

Ages: 6 to 11 years: 1,200 mg

2 to 5 years: 600 mg < 2 years: 300 mg

Extended-release capsule, tablet, solution, suspension,

and syrup formulations

CLINICAL TRIALS

Search Strategy

Studies were identified through searches performed on PubMed and review of information sent by manufacturers. Search strategy included the FDA-approved use of all drugs in this class. Randomized, comparative, controlled trials comparing agents within this class for the approved indications are considered the most relevant in this category. Studies included for analysis in the review were published in English, performed with human participants, and randomly allocated participants to comparison groups. In addition, studies must contain clearly stated, predetermined outcome measure(s) of known or probable clinical importance, use data analysis techniques consistent with the study question, and include follow-up (endpoint assessment) of at least 80% of participants entering the investigation. Despite some inherent bias found in all studies, including those sponsored and/or funded by pharmaceutical manufacturers, the studies in this therapeutic class review were determined to have results or conclusions that do not suggest systematic error in their experimental study design. While the potential influence of manufacturer sponsorship and/or funding must be considered, the studies in this review have also been evaluated for validity and importance.

This class contains a vast number of combination cough and cold products whose constituent ingredients are available both as prescription and over-the-counter medications. All of the products contained in this monograph have supporting evidence related to the safety and efficacy of their constituent

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ingredients. There are numerous placebo-controlled studies available, but none that are comparative to other agents within this class.

META-ANALYSIS

A 2005 Cochrane Review suggested caution in determining clinically significant benefits of any of the non-antibiotic treatments of the common cold other than first-dose decongestants and antihistamine-decongestant combinations.29 The review included comparison of several products, including echinacea, heated humidifier air, dextromethorphan, guaifenesin, vitamin C, zinc lozenges, and 2 combination antihistamine-decongestant products. Dexbrompheniramine 6 mg in combination with pseudoephedrine 120 mg was administered twice daily for 1 week in 1 study. Another study evaluated loratadine 5 mg in combination with pseudoephedrine 120 mg twice daily for 4 days. The authors concluded that most non-antibiotic treatments for the common cold are probably not effective; however, dextromethorphan, guaifenesin, combination antihistamine-decongestants, first-dose nasal decongestants, and, possibly, zinc lozenges show promise.

A 2012 Cochrane Review on the efficacy of OTC medications to treat an acute cough included 26 trials with antitussives, expectorants, mucolytics, antihistamines, antihistamine-decongestant combinations, and other combinations versus placebo with variable results.30 The review could not confirm clear evidence of efficacy of OTC medications to treat an acute cough. A 2007 meta-analysis was done to assess the efficacy of oral phenylephrine 10 mg as a nasal decongestant in the symptomatic relief from the common cold.31 To be included in the analysis, studies had to have a single-dose, randomized, placebo-controlled design; involve an orally-administered product in which phenylephrine 10 mg was the sole active ingredient; enroll patients with acute nasal congestion due to the common cold; evaluate nasal airway resistance as the efficacy endpoint; and have sufficient data points to allow re-analysis and/or meta-analysis of phenylephrine 10 mg and placebo. Eight studies met the inclusion criteria, involving seven cross-over studies of 113 subjects. Significant differences in favor of phenylephrine were seen in four of the 8 studies (p≤0.05). Phenylephrine was significantly more effective than placebo at the primary time points (45, 90, 120, and 180 minutes). This meta-analysis and re-analysis support the effectiveness of a single oral dose of phenylephrine 10 mg as a decongestant in adults with acute nasal congestion associated with the common cold.

SUMMARY

The common cold induces acute cough by directly irritating the upper airway structures. Viral infections of the airway can produce the common cold syndrome including rhinosinusitis. Active treatment of the symptoms associated with cough and cold may include combination products containing anticholinergics, first-generation antihistamines, opiate and non-opiate antitussives, decongestants, and expectorants. The available data do not result in any differentiation among the drugs in their particular class. These products are available in various combinations and individually as both prescription and OTC products. Awareness of the active ingredients is critical in ensuring proper dosing, patient safety, and effective use of these products.

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REFERENCES

1 Available at: https://www.clinicalkey.com/pharmacology/. Accessed June 3, 2019. 2 Fashner J, Ericson K, Werner S. Treatment of the Common Cold in Children and Adults. Am Fam Physician. 2012;86(2):153-159. Available at: https://www.aafp.org/afp/2012/0715/p153.html. Accessed June 10, 2019. 3 Common cold. Available at: https://www.cdc.gov/dotw/common-cold/index.html. Accessed June 10, 2019. 4 Cough symptoms, causes, and risk factors. Available at: http://www.lung.org/lung-health-and-diseases/lung-disease-lookup/cough/cough-symptoms-causes-risks.html. Accessed June 3, 20119. 5 Cough. Available at: https://www.nhlbi.nih.gov/health-topics/cough. Accessed June 3, 2019. 6 Fashner J, Ericson K, Werner S. Treatment of the Common Cold in Children and Adults. Am Fam Physician. 2012;86(2):153-159. Available at: https://www.aafp.org/afp/2012/0715/p153.html. Accessed June 3, 2019. 7 Malesker MA, Callahan-Lyon P, Ireland B, et al. Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated with the Common Cold. Chest Expert Panel Report. CHEST. 2017;152(5):1021-1037. Available at: http://www.chestnet.org/Guidelines-and-Resources/CHEST-Guideline-Topic-Areas/Clinical-Pulmonary. Accessed June 10, 2019. 8 Centers for Disease Control and Prevention (CDC). Infant deaths associated with cough and cold medications - two states, 2005. MMWR Weekly. 2007; 56:1–4. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5601a1.htm. Accessed June 10, 2019. 9 Food and Drug Administration, Division of Drug Risk Evaluation. Nonprescription Drug Advisory Committee meeting: cold, cough, allergy, bronchodilator, antiasthmatic drug products for over-the-counter human use. 2007:29. memorandum. Available at:

http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4323b1-02-FDA.pdf. Accessed June 3, 2019. 10 FDA. Use Caution When Giving Cough and Cold Products to Kids. Available at: https://www.fda.gov/drugs/special-features/use-caution-when-giving-cough-and-cold-products-kids. Accessed June 10, 2019. 11 FDA. OTC Cough and Cold Products: Not for Infants and Children Under 2 Years of Age. Available at: https://www.fda.gov/consumers/consumer-updates/otc-cough-and-cold-products-not-infants-and-children-under-2-years-age. Accessed June 10, 2019. 12 Schaefer MK, Shehab N, Cohen AD, et al. Adverse Events from Cough and Cold Medications in Children. Pediatrics 2008;121;783-787; DOI: 10.1542/peds.2007-3638. 13 Lowry J, Leeder JS. Over-the counter medications: update on cough and cold preparations. Pediatrics in Review. 2015; 36(7): 286-297. DOI: 10.1542/pir.36-7-286. 14 Statement from CHPA on the Voluntary Label Updates to Oral OTC Children’s Cough and Cold Medicines. October 2008. Available at: https://www.chpa.org/10_07_08labelupdatecoughmedicine.aspx. Accessed June 10, 2019. 15 Revised Product Labels for Pediatric Over-the-Counter Cough and Cold Medicines. Available at http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5743a5.htm. Accessed June 3, 2019. 16 American Academy of Pediatrics. Cough and Cold Medicine- Not for Children. 2016 Available at: https://www.aap.org/en-us/about-the-aap/aap-press-room/aap-press-room-media-center/Pages/Cough-and-Cold-Medicine-Not-for-Children.aspx. Accessed June 3, 2019. 17 Mazer-Amirshahi M, Reid N, van den Anker J, et al. Effect of cough and cold medication restriction and label changes on pediatric ingestions reported to United States poison centers. J Pediatr. 2013; 163(5):1372-6. DOI: 10.1016/j.jpeds.2013.04.054. 18 Hampton LM, Nguyen DB, Edwards JR, et al. Cough and cold medication adverse events after market withdrawal and labeling revision. Pediatrics. 2013; 132:1047. DOI: 10.1542/peds.2013-2236.

19 FDA Drug Safety Communication: FDA evaluating the potential risks of using codeine cough-and-cold medicines in children. Available at: http://www.fda.gov/Drugs/DrugSafety/ucm453125.htm. Accessed June 3, 2019. 20 FDA Drug Safety Communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women. Available at: https://www.fda.gov/Drugs/DrugSafety/ucm549679.htm. Accessed June 3, 2019. 21 FDA Drug Safety Communication: FDA requires labeling changes for prescription opioid cough and cold medicines to limit their use to adults 18 years and older. Available at: https://www.fda.gov/Drugs/DrugSafety/ucm590435.htm?utm_campaign=New%20FDA%20Drug%20Safety%20Communication%20on%20prescription%20opioid%20cough%20and%20cold%20medicines&utm_medium=email&utm_source=Eloqua. Accessed June 3, 2019. 22 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 3, 2019. 23 Available at: http://www.drugs.com/. Accessed June 3, 2019. 24 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 3, 2019. 25 Available at: http://www.drugs.com/. Accessed June 3, 2019. 26 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 3, 2019. 27 Available at: http://www.drugs.com/. Accessed June 3, 2019. 28 Clinical Pharmacology. Available at: http://www.clinicalpharmacology.com. Accessed June 3, 2019. 29 Arroll B. Non-antibiotic treatments for upper respiratory tract infections (common cold). Respir Med. 2005; 99(12):1477-84. 30 Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings. Cochrane Database of Systematic Reviews 2012, Issue 8. Art. No.: CD001831. DOI: 10.1002/14651858.CD001831.pub4. 31 Kollar C, Schneider H, Waksman J, Krusinska E. Meta-analysis of the efficacy of a single dose of phenylephrine 10 mg compared with placebo in adults with acute nasal congestion due to the common cold. Clin Ther. 2007 Jun;29(6):1057-70.

COUGH AND COLD, COLD, Appendix A; Current Product Listing

LABEL NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKETALA-HIST IR 2 MG TABLET POLY PHARMACEUT SSB ALA-HIST IR TABLET OTC (ORAL) COUGH AND COLD, COLD

ALA-HIST PE 2-10 MG TABLET POLY PHARMACEUT SSB ALA-HIST PE TABLET OTC (ORAL) COUGH AND COLD, COLDBENZEDREX INHALER B.F ASCHER & CO SSB BENZEDREX INHALER OTC (NASAL) COUGH AND COLD, COLD

CHILD MUCINEX NIGHT TIME LIQ RECKITT BENCKIS SSB CHILDREN'S MUCINEX LIQUID OTC (C) (ORAL) COUGH AND COLD, COLDCHILD MUCINEX STUFFY NOSE-CHST RECKITT BENCKIS SSB CHILDREN'S MUCINEX LIQUID OTC (C) (ORAL) COUGH AND COLD, COLD

QC COLD RELIEF PLUS EFF TABLET CHAIN DRUG GEN CHLORPHENIRAMINE/PHENYLEPHRINE/ASA TABLET EFF OTC (ORAL) COUGH AND COLD, COLDCONTAC COLD-FLU CAPLET MEDA CONSUMER H SSB CONTAC TABLET OTC (C) (ORAL) COUGH AND COLD, COLD

DECONEX IR 385-10 MG TABLET POLY PHARMACEUT SSB DECONEX IR TABLET OTC (ORAL) COUGH AND COLD, COLDDELSYM COUGH-COLD NIGHTTIME LQ RECKITT BENCKIS SSB DELSYM COUGH & COLD LIQUID OTC (C) (ORAL) COUGH AND COLD, COLD

DEXBROMPHENIR-PHENYLEPH 2-10MG WESTMINSTER PHA GEN DEXBROMPHENIRAMINE/PHENYLEPHRINE OTC (ORAL) COUGH AND COLD, COLDFLU RELIEF THERAPY NIGHT LIQ AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, COLD

FLU-SEVERE COLD-COUGH POWD PKT AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, COLDHM SEVERE COLD COUGH-FLU PKT HEALTH MART GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, COLD

QC NIGHT SEVERE COLD-COUGH PKT CHAIN DRUG GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, COLDALLERGY PLUS-SINUS HA CAPLET AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

ALLERGY-SEVERE SINUS HA CAPLET AMERISOURCE-GNP GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDQC ALLERGY & SINUS HA CAPLET CHAIN DRUG GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

THERAFLU EXPRESSMAX NIGHT CPLT GSK CONSUMER HE GEN DIPHENHYDRAMINE/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDDOXYLAMINE-PHENYLEPH 7.5-10 MG WESTMINSTER PHA GEN DOXYLAMINE/PHENYLEPHRINE OTC (ORAL) COUGH AND COLD, COLD

DURAVENT PE TABLET ALLEGIS PHARMAC SSB DURAVENT PE TABLET OTC (ORAL) COUGH AND COLD, COLDED A-HIST LIQUID EDWARDS PHARM. SSB ED A-HIST LIQUID OTC (ORAL) COUGH AND COLD, COLD

ED-A-HIST 4 MG-10 MG TABLET EDWARDS PHARM. SSB ED A-HIST TABLET OTC (ORAL) COUGH AND COLD, COLDED BRON GP LIQUID EDWARDS PHARM. SSB ED BRON GP LIQUID OTC (ORAL) COUGH AND COLD, COLD

GUAIFENESIN 200 MG TABLET MAJOR PHARMACEU GEN GUAIFENESIN 200 MG TABLET OTC (ORAL) COUGH AND COLD, COLDMUCUS RLF CHEST CONGEST 200 MG LEADER GEN GUAIFENESIN 200 MG TABLET OTC (ORAL) COUGH AND COLD, COLD

CHEST CONGEST RLF 400 MG TAB LEADER GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLDHM CHEST CONGEST RLF 400 MG TB HEALTH MART GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD

MUCOSA 400 MG TABLET TIME-CAP LABS GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLDMUCUS RELIEF 400 MG TABLET generic GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD

QC MUCUS RELIEF 400 MG CAPLET CHAIN DRUG GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLDSM CHEST CONGESTION RELIEF CAP SUNMARK GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLD

TUSSIN 400 MG TABLET AMERISOURCE-GNP GEN GUAIFENESIN 400 MG TABLET OTC (ORAL) COUGH AND COLD, COLDCHILDREN'S MUCUS RELIEF LIQ TOPCO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

GS TUSSIN MUCUS-CONG 100 MG/5 PERRIGO/GOODSEN GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDGS TUSSIN MUCUS-CONG 200 MG/10 PERRIGO/GOODSEN GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDGUAIFENESIN 100 MG/5 ML LIQUID METHOD PHARMACE GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDGUAIFENESIN 100 MG/5 ML SOLN generic GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

GUAIFENESIN 200 MG/10 ML SOLN generic GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDGUAIFENESIN 300 MG/15 ML SOLN PHARMACEUTICAL GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDHM ADULT TUSSIN CHEST CONG LIQ HEALTH MART GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

QC TUSSIN MUCUS-CONG 200 MG/10 CHAIN DRUG GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDROBAFEN 200 MG/10 ML SYRUP MAJOR PHARMACEU GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDSILTUSSIN SA 100 MG/5 ML SYR SILARX/LANNETT GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

SM TUSSIN MUCUS-CONG 200 MG/10 SUNMARK GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDTUSNEL-EX 100 MG/5 ML LIQUID LLORENS PHARM GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

TUSSIN 100 MG/5 ML SYRUP AMERISOURCE-GNP GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDTUSSIN CHEST CONGESTION LIQUID TOPCO GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLD

TUSSIN HONEY SYRUP SUNMARK GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDTUSSIN MUCUS-CONG 200 MG/10 generic GEN GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, COLDHM MUCUS ER 1,200 MG TABLET HEALTH MART GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDHM MUCUS ER 600 MG TABLET HEALTH MART GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD

MUCUS ER 600 MG TABLET AMERISOURCE-GNP GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDMUCUS RELIEF ER 1,200 MG TAB generic GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD

MUCUS RELIEF ER 600 MG TABLET generic GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDMUCUS-ER MAX 1,200 MG TABLET AMERISOURCE-GNP GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDQC MUCUS RELIEF ER 1,200 MG TB CHAIN DRUG GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDQC MUCUS RELIEF ER 600 MG TAB CHAIN DRUG GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD

SM MUCUS ER 600 MG TABLET SUNMARK GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDSM MUCUS RELIEF ER 600 MG TAB SUNMARK GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLDSM MUCUS-ER MAX 1,200 MG TAB SUNMARK GEN GUAIFENESIN TABLET ER OTC (ORAL) COUGH AND COLD, COLD

SM CHEST CONGESTION CAPLET SUNMARK GEN GUAIFENESIN/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDCHEST-SINUS CONGST RLF TABLET AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD

HM MUCUS RLF D ER 600-60 MG TB HEALTH MART GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLDMUCUS RELIEF D ER 600-60 MG TB RUGBY GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLD

MUCUS RELIEF SINUS TABLET MAJOR PHARMACEU GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLDSM CHEST CONG RELIEF PE CAPLET SUNMARK GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLDSM MUCUS RELIEF D ER 600-60 MG SUNMARK GEN GUAIFENESIN/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, COLDMUCUS RELIEF COLD-SINUS CAPLET AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS CONGST-PAIN 325-200-5 MG LEADER GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

SINUS RELIEF PRESS-PAIN CAPLET AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS RELIEF SEV CONGEST CPLT AMERISOURCE-GNP GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

SM SINUS SEVERE CAPLET SUNMARK GEN GUAIFENESIN/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDGUAIFENESIN-PSE ER 1200-120 MG DR.REDDY'S LAB GEN GUAIFENESIN/PSE TABLET ER OTC (ORAL) COUGH AND COLD, COLD

GUAIFENESIN-PSE ER 600-60 MG generic GEN GUAIFENESIN/PSE TABLET ER OTC (ORAL) COUGH AND COLD, COLDMUCUS D ER 600-60 MG TABLET PERRIGO CO. GEN GUAIFENESIN/PSE TABLET ER OTC (ORAL) COUGH AND COLD, COLD

GUAIFENESIN-PSE 375-60 MG TAB XSPIRE PHARMA GEN GUAIFENESIN/PSEUDOEPHEDRNE TABLET OTC (ORAL) COUGH AND COLD, COLDHISTEX-PE SYRUP ALLEGIS PHARMAC SSB HISTEX-PE LIQUID OTC (ORAL) COUGH AND COLD, COLD

HM COLD-SINUS RELIEF CAPLET HEALTH MART GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLDIBUPROFEN COLD-SINUS CPLT AMERISOURCE-GNP GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD

SM COLD-SINUS RELIEF CAPLET SUNMARK GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLDSM IBUPROFEN COLD & SINUS CPLT SUNMARK GEN IBUPROFEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD

QC VAPOR INHALER CHAIN DRUG GEN LEVMETAMFETAMINE INHALER OTC (NASAL) COUGH AND COLD, COLDLIQUITUSS GG 200 MG/5 ML LIQ CAPELLON SSB LIQUITUSS GG LIQUID OTC (ORAL) COUGH AND COLD, COLD

LODRANE D CAPSULE VALEANT/BAUSCH SSB LODRANE D CAPSULE OTC (ORAL) COUGH AND COLD, COLDLOHIST-D LIQUID LARKEN LABS SSB LOHIST-D LIQUID OTC (ORAL) COUGH AND COLD, COLDMAXIFED TABLET MCR AMERICAN PH SSB MAXIFED TABLET OTC (ORAL) COUGH AND COLD, COLD

MUCINEX D ER 1,200-120 MG TAB RECKITT BENCKIS SSB MUCINEX D TABLET ER 12H OTC (ORAL) COUGH AND COLD, COLDMUCINEX D ER 600-60 MG TABLET RECKITT BENCKIS SSB MUCINEX D TABLET ER 12H OTC (ORAL) COUGH AND COLD, COLD

MUCINEX ER 1,200 MG TABLET RECKITT BENCKIS SSB MUCINEX ER TABLET OTC (ORAL) COUGH AND COLD, COLDMUCINEX ER 600 MG TABLET RECKITT BENCKIS SSB MUCINEX ER TABLET OTC (ORAL) COUGH AND COLD, COLD

MUCINEX FAST-MAX COLD-SINUS TB RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-SINUS TABLET OTC (ORAL) COUGH AND COLD, COLDMUCINEX FAST-MAX NITE COLD-FLU RECKITT BENCKIS SSB MUCINEX FAST-MAX NITE COLD-FLU LIQUID OTC (ORAL) COUGH AND COLD, COLDMUCINEX SINUS-MAX NITE CONGEST RECKITT BENCKIS SSB MUCINEX FAST-MAX NITE COLD-FLU LIQUID OTC (ORAL) COUGH AND COLD, COLDCHILD MUCINEX CHEST 100 MG PKT RECKITT BENCKIS SSB MUCINEX GRAN PACK OTC (ORAL) COUGH AND COLD, COLDMUCINEX SINUS-MAX NASAL SPRAY RECKITT BENCKIS GEN MUCINEX SINUS-MAX SPRAY OTC (NASAL) COUGH AND COLD, COLD

1

COUGH AND COLD, COLD, Appendix A; Current Product Listing

LABEL NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKETMUCINEX SINUS-MAX SEVERE LIQ RECKITT BENCKIS SSB MUCINEX SINUS-MAX LIQUID OTC (ORAL) COUGH AND COLD, COLD

MUCINEX SINUS-MAX SEVERE CPLT RECKITT BENCKIS SSB MUCINEX SINUS-MAX TABLET OTC (ORAL) COUGH AND COLD, COLDHM SINUS AND COLD-D CAPLET HEALTH MART GEN NAPROXEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD

SINUS AND COLD-D CAPLET AMERISOURCE-GNP GEN NAPROXEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLDSM SINUS AND COLD-D CAPLET SUNMARK GEN NAPROXEN/PSE TABLET OTC (ORAL) COUGH AND COLD, COLD

NASOPEN PE LIQUID G.M. PHARM SSB NASOPEN PE LIQUID OTC (ORAL) COUGH AND COLD, COLDNOHIST-LQ LIQUID LARKEN LABS SSB NOHIST-LQ LIQUID OTC (ORAL) COUGH AND COLD, COLDNOREL AD TABLET US PHARMACEUTIC SSB NOREL AD TABLET OTC (ORAL) COUGH AND COLD, COLD

CHILD MUCINEX STUFFY NOSE SPRY RECKITT BENCKIS GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLDGS NASAL SPRAY 0.05% PERRIGO/GOODSEN GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD

GS SINUS NASAL SPRAY 0.05% PERRIGO/GOODSEN GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLDHM ORIGINAL NASAL SPRAY 0.05% HEALTH MART GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD

HM SINUS NASAL SPRAY 0.05% HEALTH MART GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLDNASAL DECONGESTANT 0.05% SPRAY MAJOR PHARMACEU GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD

NASAL SPRAY 0.05% generic GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLDNASAL SPRAY ORIGINAL 0.05% AMERISOURCE-GNP GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLDNO DRIP 0.05% NASAL SPRAY generic GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD

SM NASAL SPRAY 0.05% SUNMARK GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLDSM NASAL SPRAY SINUS SUNMARK GEN OXYMETAZOLINE 12 HR NASAL SPRAY OTC (NASAL) COUGH AND COLD, COLD

NASAL SPRAY 0.05% generic GEN OXYMETAZOLINE MIST OTC (NASAL) COUGH AND COLD, COLDSINUS RELIEF 0.05% NASAL SPRAY TOPCO GEN OXYMETAZOLINE MIST OTC (NASAL) COUGH AND COLD, COLD

SM NASAL 0.05% SPRAY SUNMARK GEN OXYMETAZOLINE MIST OTC (NASAL) COUGH AND COLD, COLD4 WAY 1% NASAL SPRAY NOVARTIS/GSK CO GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLD

GS NASAL FOUR 1% NASAL SPRAY PERRIGO/GOODSEN GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLDNASAL FOUR 1% NASAL SPRAY TOPCO GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLD

NASAL SPRAY 1% AMERISOURCE-GNP GEN PHENYLEPHRINE FOUR SPRAY OTC (NASAL) COUGH AND COLD, COLDHM NOSE DROPS HEALTH MART GEN PHENYLEPHRINE NOSE DROPS OTC (NASAL) COUGH AND COLD, COLD

NOSE DROPS AMERISOURCE-GNP GEN PHENYLEPHRINE NOSE DROPS OTC (NASAL) COUGH AND COLD, COLDSM NOSE DROPS SUNMARK GEN PHENYLEPHRINE NOSE DROPS OTC (NASAL) COUGH AND COLD, COLD

ACETAMINOPHEN CONGST-PAIN CPLT MAJOR PHARMACEU GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDCONTAC COLD-FLU DAY CAPLET MEDA CONSUMER H GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

GS SINUS CONGESTION-PAIN CPLT PERRIGO/GOODSEN GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDMAPAP SINUS CAPLET MAJOR PHARMACEU GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

QC SINUS PAIN RELIEF CAPLET CHAIN DRUG GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS CONGESTION-PAIN CAPLET generic GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

SINUS PRESSURE-PAIN CAPLET LEADER GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLDSM SINUS MAXIMUM STRENGTH CPLT SUNMARK GEN PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, COLD

ALLERGY MULTI-SYMPTOM CAPLET generic GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDPAIN RELIEF ALLERGY CAPLET AMERISOURCE-GNP GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD

QC ALLERGY RELIEF MUL-SYM CPLT CHAIN DRUG GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS CONGESTION-PAIN CAPLET generic GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS RELIEF-CONG-PAIN CAPLET AMERISOURCE-GNP GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD

SM ALLERGY MULTI-SYMPTOM CPLT SUNMARK GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS CONG-PAIN DAY-NIGHT CPL AMERISOURCE-GNP GEN PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET SEQUELS OTC (ORAL) COUGH AND COLD, COLD

CHILD COLD-ALLERGY LIQUID LEADER GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLDCHILD TRIAMINIC COLD-ALLERGY NOVARTIS/GSK CO GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLDCHILDREN'S COLD-ALLERGY ELIXIR TOPCO GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD

COLD-ALLERGY ELIXIR AMERISOURCE-GNP GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLDDIMAPHEN ELIXIR MAJOR PHARMACEU GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD

GS CHILD COLD-ALLERGY SOLUTION PERRIGO/GOODSEN GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLDHM CHILD COLD-ALLERGY ELIXIR HEALTH MART GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLDSM CHILD COLD-ALLERGY LIQUID SUNMARK GEN PHENYLEPHRINE/BROMPHENIRAMINE SOLUTION OTC (ORAL) COUGH AND COLD, COLD

BROHIST D 10-4 MG TABLET ALLEGIS PHARMAC GEN PHENYLEPHRINE/BROMPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDRU-HIST D 10-4 MG TABLET ALLEGIS PHARMAC GEN PHENYLEPHRINE/BROMPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD

COLD-ALLERGY TABLET AMERISOURCE-GNP GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSINUS-ALLERGY PE 4-10 MG TAB AMERISOURCE-GNP GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD

SINUS-ALLERGY PE TABLET AMERISOURCE-GNP GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSM COLD-ALLERGY PE TABLET SUNMARK GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSM SINUS-ALLERGY PE TABLET SUNMARK GEN PHENYLEPHRINE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD

CHILDS TRIACTING COLD-COUGH LQ TOPCO GEN PHENYLEPHRINE/DIPHENHYDRAMINE LIQUID OTC (ORAL) COUGH AND COLD, COLDPROMETHAZINE-PHENYLEPHRINE SYR HI-TECH/AKORN C GEN PHENYLEPHRINE/PROMETHAZINE SYRUP (ORAL) COUGH AND COLD, COLD

POLY HIST FORTE 10.5-10 MG TAB POLY PHARMACEUT SSB POLY HIST FORTE TABLET OTC (ORAL) COUGH AND COLD, COLDPOLY HIST FORTE 7.5-10 MG TAB POLY PHARMACEUT SSB POLY HIST FORTE TABLET OTC (ORAL) COUGH AND COLD, COLD

POLY-VENT IR TABLET POLY PHARMACEUT SSB POLY-VENT IR TABLET OTC (ORAL) COUGH AND COLD, COLDV-R VALU-TAPP ELIXIR SUNMARK GEN PSE/BROMPHENIRAMINE LIQUID OTC (ORAL) COUGH AND COLD, COLD

SUDOGEST COLD AND ALLERGY TAB MAJOR PHARMACEU GEN PSE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLDSUDOGEST SINUS AND ALLERGY TAB MAJOR PHARMACEU GEN PSE/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, COLD

APRODINE TABLET MAJOR PHARMACEU GEN PSE/TRIPROLIDINE TABLET OTC (ORAL) COUGH AND COLD, COLDRESCON TABLET CAPELLON SSB RESCON TABLET OTC (ORAL) COUGH AND COLD, COLDRYMED TABLET EDWARDS PHARM. SSB RYMED TABLET OTC (ORAL) COUGH AND COLD, COLD

RYNEX PE LIQUID EDWARDS PHARM. SSB RYNEX PE SOLUTION OTC (ORAL) COUGH AND COLD, COLDSINUS RELIEF 1% NASAL SPRAY LEADER GEN SINUS RELIEF SPRAY OTC (NASAL) COUGH AND COLD, COLD

STAHIST AD TABLET MAGNA PHARM SSB STAHIST AD TABLET OTC (ORAL) COUGH AND COLD, COLDSTAHIST LIQUID MAGNA PHARM SSB STAHIST LIQUID OTC (ORAL) COUGH AND COLD, COLD

TUSNEL PEDIATRIC DROPS LLORENS PHARM SSB TUSNEL PEDIATRIC DROPS OTC (ORAL) COUGH AND COLD, COLD

2

COUGH AND COLD, NARCOTIC, Appendix A; Current Product Listing

LABEL NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKETCAPCOF LIQUID CAPITAL PHARMAC SSB CAPCOF LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC

CODEINE-GUAIFEN 10-100 MG/5 ML generic GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICGUAIATUSSIN AC LIQUID HI-TECH/AKORN C GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC

GUAIFEN-CODEINE 100-10 MG/5 ML PHARMACEUTICAL GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICGUAIFEN-CODEINE 200-20 MG/10ML PHARMACEUTICAL GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC

GUAIFENESIN AC COUGH SYRUP RISING PHARM GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICGUAIFENESIN-CODEINE SYRUP PHARMACEUTICAL GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC

VIRTUSSIN AC 10-100 MG/5 ML LQ VIRTUS PHARMACE GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICVIRTUSSIN AC W-ALC 10-100 MG/5 VIRTUS PHARMACE GEN GUAIFENESIN/CODEINE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICGUAIFENESIN DAC ORAL SOLUTION RISING PHARM GEN GUAIFENESIN/PSE/CODEINE SYRUP OTC (ORAL) COUGH AND COLD, NARCOTIC

VIRTUSSIN DAC LIQUID VIRTUS PHARMACE GEN GUAIFENESIN/PSE/CODEINE SYRUP OTC (ORAL) COUGH AND COLD, NARCOTICHISTEX-AC SYRUP ALLEGIS PHARMAC SSB HISTEX-AC SYRUP OTC (ORAL) COUGH AND COLD, NARCOTIC

HYDROCODONE-CHLORPHEN ER SUSP generic GEN HYDROCODONE/CHLORPHENIRAMINE SUSPENSION ER 12H (ORAL) COUGH AND COLD, NARCOTICHYDROCODONE-HOMATROPINE SOLN generic GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC

HYDROCODONE-HOMATROPINE SYRUP generic GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTICHYDROMET SYRUP ACTAVIS/TEVA GEN HYDROCODONE/HOMATROPINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC

HYDROCODONE-HOMATROPINE 5-1.5 generic GEN HYDROCODONE/HOMATROPINE TABLET (ORAL) COUGH AND COLD, NARCOTICMAXI-TUSS CD LIQUID MCR AMERICAN PH SSB MAXI-TUSS CD OTC (ORAL) COUGH AND COLD, NARCOTICM-CLEAR WC LIQUID R.A.MC NEIL CO. SSB M-CLEAR WC LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC

M-END PE LIQUID R.A.MC NEIL CO. SSB M-END PE LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICNINJACOF-XG LIQUID CENTURION LABS SSB NINJACOF-XG LIQUID OTC (ORAL) COUGH AND COLD, NARCOTIC

POLY-TUSSIN AC LIQUID POLY PHARMACEUT SSB POLY-TUSSIN AC LIQUID OTC (ORAL) COUGH AND COLD, NARCOTICPROMETHAZINE-CODEINE SYRUP generic GEN PROMETHAZINE/CODEINE SYRUP (ORAL) COUGH AND COLD, NARCOTIC

PROMETHAZINE-PE-CODEINE SYRUP HI-TECH/AKORN C GEN PROMETHAZINE/PHENYLEPHRINE/CODEINE SYRUP (ORAL) COUGH AND COLD, NARCOTICTUSSICAPS 10 MG-8 MG CAPSULE VALEANT/BAUSCH SSB TUSSICAPS CAPSULE ER 12H (ORAL) COUGH AND COLD, NARCOTICZ-TUSS AC 2 MG-9 MG/5 ML LIQ MAGNA PHARM SSB Z-TUSS AC OTC (ORAL) COUGH AND COLD, NARCOTIC

1

COUGH AND COLD, NON-NARCOTIC, Appendix A; Current Product Listing

LABEL NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKETALAHIST CF TABLET POLY PHARMACEUT SSB ALAHIST CF TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICALAHIST DM LIQUID POLY PHARMACEUT SSB ALA-HIST DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICAQUANAZ TABLET CAPITAL PHARMAC SSB AQUANAZ OTC (ORAL) COUGH AND COLD, NON-NARCOTICATUSS DA LIQUID MAGNA PHARM SSB ATUSS DA LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

BENZONATATE PERLE 100 MG CAP GREENSTONE LLC. GEN BENZONATATE CAPSULE (AG) (ORAL) COUGH AND COLD, NON-NARCOTICBENZONATATE 100 MG CAPSULE generic GEN BENZONATATE CAPSULE (ORAL) COUGH AND COLD, NON-NARCOTICBENZONATATE 150 MG CAPSULE ASCEND LABORATO GEN BENZONATATE CAPSULE (ORAL) COUGH AND COLD, NON-NARCOTICBENZONATATE 200 MG CAPSULE generic GEN BENZONATATE CAPSULE (ORAL) COUGH AND COLD, NON-NARCOTIC

BROMFED DM COUGH SYRUP MORTON GROVE PH SSB BROMFED DM SYRUP (ORAL) COUGH AND COLD, NON-NARCOTICAP-HIST DM LIQUID ALLEGIS PHARMAC GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

CHILDREN'S COLD-COUGH ELIXIR TOPCO GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILDREN'S COLD-COUGH LIQUID LEADER GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COLD-COUGH ELIXIR AMERISOURCE-GNP GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICDIMAPHEN DM ELIXIR MAJOR PHARMACEU GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICENDACOF-DM LIQUID LARKEN LABS GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

GS CHILDREN'S COLD-COUGH SOLN PERRIGO/GOODSEN GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM CHILD'S COLD-COUGH ELIXIR HEALTH MART GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM COLD-COUGH DM LIQUID SUNMARK GEN BROMPHENIRAMINE/PHENYLEPHRINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICBROMPHENIR-PSEUDOEPHED-DM SYR generic GEN BROM-PSE-DM SYRUP (ORAL) COUGH AND COLD, NON-NARCOTIC

CAPMIST DM TABLET CAPITAL PHARMAC SSB CAPMIST DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCAPRON DM LIQUID CAPITAL PHARMAC SSB CAPRON DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

CAPRON DMT TABLET CAPITAL PHARMAC SSB CAPRON DMT OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILD DAYCLEAR ALLERGY CHEW TB G.M. PHARM SSB CHILDREN'S DAYCLEAR ALLERGY CHEWABLE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

CHLO HIST ORAL SOLUTION R.A.MC NEIL CO. SSB CHLO HIST SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHLO TUSS LIQUID R.A.MC NEIL CO. SSB CHLO TUSS LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DAY MULTI-SYMP FLU-SEVERE COLD LEADER SSB DAY MULTI-SYMP FLU-SEVERE COLD POWDER PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTICDAYCLEAR ALLERGY 25-50 MG TAB G.M. PHARM SSB DAYCLEAR ALLERGY RELIEF OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DECONEX DMX 17.5-385-10 MG TAB POLY PHARMACEUT SSB DECONEX DMX TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICDECONEX DMX 17.5-400-10 MG TAB POLY PHARMACEUT SSB DECONEX DMX TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILD DELSYM COUGH 30 MG/5 ML RECKITT BENCKIS SSB DELSYM SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICDELSYM 30 MG/5 ML SUSPENSION RECKITT BENCKIS SSB DELSYM SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

ROBAFEN COUGH 15 MG LIQUIDGEL RUGBY GEN DEXTROMETHORPHAN CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOUGH RELIEF LIQUID AMERISOURCE-GNP GEN DEXTROMETHORPHAN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN COUGH LIQUID generic GEN DEXTROMETHORPHAN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

CHILD COUGH DM ER 30 MG/5 ML LEADER GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOUGH DM ER 30 MG/5 ML SUSP generic GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DEXTROMETHORPHAN ER 30 MG/5 ML PERRIGO CO. GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS CHLD COUGH DM ER 30 MG/5 ML PERRIGO/GOODSEN GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS COUGH DM ER 30 MG/5 ML SUSP PERRIGO/GOODSEN GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM COUGH DM ER 30 MG/5 ML SUSP HEALTH MART GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM COUGH DM ER 30 MG/5 ML SUSP SUNMARK GEN DEXTROMETHORPHAN SUSPENSION ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

FLU HBP TABLET LEADER GEN DM/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS NIGHTTIME COLD-FLU SOFTGEL PERRIGO/GOODSEN GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

HM NIGHT TIME LIQUID CAP HEALTH MART GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHT COLD-FLU RELIEF LIQ GEL LEADER GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHT TIME COLD-FLU SOFTGEL AMERISOURCE-GNP GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHTTIME COLD-FLU RLF SFTGL LEADER GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICQC NIGHTTIME COLD-FLU SFTGL CHAIN DRUG GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM NIGHTTIME COLD-FLU SFTGL SUNMARK GEN DM/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICALL-NITE COLD-FLU RELIEF LIQ MAJOR PHARMACEU GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

CONTAC COLD-FLU NIGHT LIQUID MEDA CONSUMER H GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS NIGHTTIME COLD-FLU LIQUID PERRIGO/GOODSEN GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM NIGHT TIME COLD-FLU LIQ HEALTH MART GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHT TIME COLD-FLU LIQUID AMERISOURCE-GNP GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

NIGHTTIME COLD AND FLU LIQUID LEADER GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHTTIME COLD-FLU LIQUID LEADER GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM NITE TIME COLD-FLU LIQUID SUNMARK GEN DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM COUGH & RUNNY NOSE LIQUID SUNMARK GEN DM/CHLORPHENIRAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COUGH-COLD HBP TABLET LEADER GEN DM/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOUGH-COLD TABLET MAJOR PHARMACEU GEN DM/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DAY TIME COLD-FLU SOFTGEL AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICDAYTIME COLD-FLU RELIEF SFTGL LEADER GEN DM/PHENYLEPHRINE/APAP CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS DAYTIME COLD-FLU SOFTGEL PERRIGO/GOODSEN GEN DM/PHENYLEPHRINE/APAP CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM DAY TIME COLD-FLU RLF SFTGL SUNMARK GEN DM/PHENYLEPHRINE/APAP CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICDAY TIME COLD-FLU LIQUID AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DAYTIME COLD-FLU RELIEF LIQUID LEADER GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS DAY TIME COLD-FLU LIQUID PERRIGO/GOODSEN GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM DAY TIME COLD-FLU LIQUID SUNMARK GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM DAY TIME COLD-FLU RELIEF LQ SUNMARK GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTHERAFLU EXPRESSMAX COLD-COUGH NOVARTIS/GSK CO GEN DM/PHENYLEPHRINE/APAP LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

FLU-SEVERE COLD-COUGH DAY PKT LEADER GEN DM/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM SEVERE COLD-COUGH-FLU PCKT HEALTH MART GEN DM/PHENYLEPHRINE/APAP POWDER PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COLD HEAD CONGESTION CAPLET generic GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOLD MULTI-SYMPTOM CAPLET TOPCO GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COLD RELIEF MULTI-SYMPTOM CPLT AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICDAYTIME COLD RELIEF CAPLET LEADER GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MAPAP COLD FORMULA CAPLET MAJOR PHARMACEU GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICTHERAFLU EXPRESSMAX DAY CAPLET GSK CONSUMER HE GEN DM/PHENYLEPHRINE/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COLD RELIEF HEAD CONGEST CPLT AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET SEQUELS OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILD TRIAMINIC M-S FEVER-COLD NOVARTIS/GSK CO GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE SUSPENSION OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILDRENS PLUS M-S COLD SUSP AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE SUSPENSION OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILDREN'S PLUS M-S COLD SUSP TOPCO GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE SUSPENSION OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOLD HEAD CONGESTION CAPLET generic GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOLD MULTI-SYMPTOM CAPLET TOPCO GEN DM/PHENYLEPHRINE/APAP/CHLORPHENIRAMINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COLD MULTI-SYMPTOM NIGHT LIQ AMERISOURCE-GNP GEN DM/PHENYLEPHRINE/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHTTIME SEVERE COLD-FLU LIQ LEADER GEN DM/PHENYLEPHRINE/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM DAYTIME SOFTGEL SUNMARK GEN DM/PSE/APAP CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM NITE TIME COLD-FLU REL SFGL SUNMARK GEN DM/PSE/APAP/DOXYLAMINE CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICPEDIATRIC COUGH-COLD LIQUID SILARX/LANNETT GEN DM/PSE/CHLORPHENIRAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

NIGHT TIME COUGH LIQUID AMERISOURCE-GNP GEN DOXYLAMINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIGHTTIME COUGH LIQUID LEADER GEN DOXYLAMINE/DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DURAFLU 325-20-200-60 MG TAB POLY PHARMACEUT SSB DURAFLU TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICED A-HIST DM TABLET EDWARDS PHARM. SSB ED A-HIST DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICED-A-HIST DM LIQUID EDWARDS PHARM. SSB ED-A-HIST DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DM-GUAIF-PE 17.5-385-10 MG TAB WESTMINSTER PHA GEN GUAIFEN/DEXTROMETHORPHAN/PE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

1

COUGH AND COLD, NON-NARCOTIC, Appendix A; Current Product Listing

LABEL NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKET

GUAIFENESIN-DM ER 1,200-60 MG OHM LABS. GEN GUAIFENESIN/DEXTROMETHORPHAN TABLET ER OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSNEL DIABETIC LIQUID LLORENS PHARM GEN GUAIFENESIN/DM LIQUID (ORAL) COUGH AND COLD, NON-NARCOTIC

CHILD MUCUS RELIEF COUGH LIQ generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILD MUCUS-COUGH RELIEF LIQ LEADER GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COUGH DM SYRUP RUGBY GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICDELSYM COUGH+CHEST CNGST DM LQ RECKITT BENCKIS GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DIABETIC SILTUSSIN-DM MAX-STR SILARX/LANNETT GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS CHILD MUCUS RLF COUGH LIQ PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

GS TUSSIN DM COUGH SYRUP PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS TUSSIN DM COUGH-CHEST SOLN PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

GS TUSSIN DM LIQUID PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS TUSSIN DM MAX LIQUID PERRIGO/GOODSEN GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

GUAIFENESIN DM SYRUP generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGUAIFENESIN-DM 100-10 MG/5 ML MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

GUAIFENESIN-DM 200-20 MG/10 ML MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM ADT TUSSIN COUGH CONG DM LQ HEALTH MART GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

HM ADULT TUSSIN DM SYRUP HEALTH MART GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM TUSSIN DM MAX LIQUID HEALTH MART GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCUS RELIEF DM MAX LIQUID generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICQC TUSSIN DM LIQUID CHAIN DRUG GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

ROBAFEN DM CGH-CHEST CONG SYRP MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICROBAFEN DM COUGH LIQUID MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICROBAFEN DM COUGH SYRUP MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

ROBAFEN DM PEAK COLD LIQUID MAJOR PHARMACEU GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSILTUSSIN DM COUGH SYRUP SILARX/LANNETT GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SILTUSSIN DM DAS LIQUID SILARX/LANNETT GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM MUCUS RELIEF COUGH LIQUID SUNMARK GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM TUSSIN DM 400-20 MG/20 ML SUNMARK GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM TUSSIN DM LIQUID SUNMARK GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM TUSSIN DM SYRUP SUNMARK GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSNEL DIABETIC LIQUID LLORENS PHARM GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN DM 400-20 MG/20 ML LIQ LEADER GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSSIN DM CLEAR SYRUP AMERISOURCE-GNP GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN DM LIQUID generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSSIN DM MAX LIQUID generic GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN DM SYRUP AMERISOURCE-GNP GEN GUAIFENESIN/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCUS RLF DM ER 600-30 MG TAB generic GEN GUAIFENESIN/DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHEST CONGST-COUGH RELIEF TAB AMERISOURCE-GNP GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCOSA DM 400-20 MG TABLET TIME-CAP LABS GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCUS RELIEF DM 20-400 MG TAB MAJOR PHARMACEU GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCUS RELIEF DM COUGH TABLET LEADER GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

QC MUCUS RELIEF DM TABLET CHAIN DRUG GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM CHEST CONGEST RLF DM CAPLET SUNMARK GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSSIN DM 400-20 MG TABLET AMERISOURCE-GNP GEN GUAIFENESIN/DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILD MUCUS RELIEF M-S COLD LQ generic GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICDM-GUAIF-PE 18-200-10 MG/15 ML WESTMINSTER PHA GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS CHILD MUCUS RELIEF M-S COLD PERRIGO/GOODSEN GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM CHILD MUCUS RELIEF M-S COLD SUNMARK GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN CF MAX M-S COLD LIQUID AMERISOURCE-GNP GEN GUAIFENESIN/DM/PHENYLEPHRINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

GS TUSSIN CF LIQUID PERRIGO/GOODSEN GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTICHM ADT TUSSIN M-S COLD LIQUID HEALTH MART GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

QC TUSSIN CF LIQUID CHAIN DRUG GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTICROBAFEN CF LIQUID MAJOR PHARMACEU GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM TUSSIN CF SYRUP SUNMARK GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSSIN CF COUGH-COLD LIQUID TOPCO GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN CF COUGH-COLD SYRUP AMERISOURCE-GNP GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSSIN CF MULTI-SYMPTOM COLD LEADER GEN GUAIFENESIN/DM/PHENYLEPHRINE SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTICNIVANEX DMX TABLET NIVAGEN PHARMAC GEN GUAIFENESIN/DM/PHENYLEPHRINE TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

HISTEX-DM SYRUP ALLEGIS PHARMAC SSB HISTEX-DM SYRUP OTC (ORAL) COUGH AND COLD, NON-NARCOTICLOHIST-DM SYRUP LARKEN LABS SSB LOHIST-DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MAXICHLOR PEH DM TABLET MCR AMERICAN PH SSB MAXICHLOR PEH DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICMAXI-TUSS DM LIQUID MCR AMERICAN PH SSB MAXI-TUSS DM OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

M-END DMX LIQUID R.A.MC NEIL CO. SSB M-END DMX LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICCHILD MUCINEX COUGH 5-100MG PK RECKITT BENCKIS SSB MUCINEX COUGH GRAN PACK OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCINEX DM ER 1,200-60 MG TAB RECKITT BENCKIS SSB MUCINEX DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX DM ER 600-30 MG TABLET RECKITT BENCKIS SSB MUCINEX DM TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX FAST-MAX COLD-FLU CAP RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-FLU CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCINEX FAST-MAX COLD-FLU-THRT RECKITT BENCKIS SSB MUCINEX FAST-MAX COLD-FLU-THROAT CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX FAST-MAX CONGEST-COUGH RECKITT BENCKIS SSB MUCINEX FAST-MAX CONGEST-COUGH TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCINEX FAST-MAX DAY-NITE LIQ RECKITT BENCKIS SSB MUCINEX FAST-MAX DAY-NITE CONG LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX FAST-MAX DAY-NITE CONG RECKITT BENCKIS SSB MUCINEX FAST-MAX DAY-NITE CONG TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX FAST-MAX DM MAX LIQUID RECKITT BENCKIS SSB MUCINEX FAST-MAX DM MAX LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

MUCINEX FAST-MAX SEV COLD LIQ RECKITT BENCKIS SSB MUCINEX FAST-MAX SEVERE COLD LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX SINUS-MAX CONG-PAIN CP RECKITT BENCKIS GEN MUCINEX SINUS-MAX CONGESTION PAIN OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX SINUS-MAX PRESSURE-CGH RECKITT BENCKIS SSB MUCINEX SINUS-MAX CONGESTION RELIEF CAPSULE OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCINEX SINUS-MAX PRESSURE-CGH RECKITT BENCKIS GEN MUCINEX SINUS-MAX PRESSURE COUGH OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCUS DM MAX ER 1,200-60 MG TB generic GEN MUCUS DM MAX TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCUS RLF DM MAX ER 1200-60 MG generic GEN MUCUS DM MAX TABLET ER 12H OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

NINJACOF LIQUID CENTURION LABS SSB NINJACOF LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICNINJACOF-D LIQUID CENTURION LABS SSB NINJACOF-D OTC (ORAL) COUGH AND COLD, NON-NARCOTICNOHIST-DM LIQUID LARKEN LABS SSB NOHIST-DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TRIAMINIC DAYTIME COLD-COUGH NOVARTIS/GSK CO GEN PHENYLEPHRINE/DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOLD HEAD CONGESTION CAPLET generic GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

COLD RELIEF MULTI-SYMPTOM CPLT AMERISOURCE-GNP GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICCOLD RLF HEAD CONGESTION CPLT AMERISOURCE-GNP GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS SEVERE DAY COLD-FLU CAPLET PERRIGO/GOODSEN GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

HM SEVERE COLD-FLU CAPLET HEALTH MART GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICMUCUS RLF COLD-FLU-THROAT CPLT AMERISOURCE-GNP GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SEVERE COLD-FLU CAPLET LEADER GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICSM COLD-FLU SEVERE CAPLET SUNMARK GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN CAPLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

DAYTIME SEVERE COLD-FLU LIQUID LEADER GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICGS SEVERE DAYTIME COLD-FLU LIQ PERRIGO/GOODSEN GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SEVERE DAYTIME COLD-FLU LIQ AMERISOURCE-GNP GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSSIN CF MAX SEVERE M-S COLD LEADER GEN PHENYLEPHRINE/DM/APAP/GUAIFENESIN LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

POLY-HIST DM LIQUID POLY PHARMACEUT SSB POLY-HIST DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

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COUGH AND COLD, NON-NARCOTIC, Appendix A; Current Product Listing

LABEL NAME MANUFACTURER DRUG TYPE PROVIDER SYNERGIES BRAND NAME ROUTE PROVIDER SYNERGIES MARKET BASKET

POLY-HIST PD LIQUID POLY PHARMACEUT SSB POLY-HIST PD DROPS OTC (ORAL) COUGH AND COLD, NON-NARCOTICPOLYTUSSIN DM SYRUP POLY PHARMACEUT SSB POLYTUSSIN DM OTC (ORAL) COUGH AND COLD, NON-NARCOTICPOLY-VENT DM TABLET POLY PHARMACEUT SSB POLY-VENT DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

PROMETHAZINE-DM SYRUP MORTON GROVE PH GEN PROMETHAZINE/DM SYRUP (ORAL) COUGH AND COLD, NON-NARCOTICV-R NON-ASPIRIN FLU GELCAP SUNMARK GEN PSE/DM/APAP TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

SM NITE TIME LIQUID SUNMARK GEN PSE/DM/APAP/DOXYLAMINE LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICRESCON-DM LIQUID CAPELLON SSB RESCON-DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICRYNEX DM LIQUID EDWARDS PHARM. SSB RYNEX DM SOLUTION OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSNEL DM LIQUID LLORENS PHARM GEN TUSNEL DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSNEL DM PEDIATRIC LIQUID LLORENS PHARM GEN TUSNEL DM PEDIATRIC LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

TUSNEL CAPLET LLORENS PHARM SSB TUSNEL TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTICTUSNEL DM PEDIATRIC DROPS LLORENS PHARM SSB TUSNEL-DM PEDIATRIC DROPS OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

VANACOF DM 18-200-10 MG/15 ML G.M. PHARM SSB VANACOF DM LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICVANACOF DMX 18-396-10 MG/15 ML G.M. PHARM SSB VANACOF DMX LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

VANACOF LIQUID G.M. PHARM SSB VANACOF LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTICVANATAB DM CAPLET G.M. PHARM SSB VANATAB DM TABLET OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

Y-TUSS LIQUID MAGNA PHARM SSB Y-TUSS LIQUID OTC (ORAL) COUGH AND COLD, NON-NARCOTIC

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