Coronary Phantom Design for Coronary Phantom Design for K-edge AngiographyK-edge Angiography

John JorgensenSarah Pachtman

Punam PatelMarcus Spallek

Advisor: Dr. Frank Carroll

MXI SystemsMXI Systems

MX 200– Applications

• Radiotherapy• Crystallography• Mammography• Pediatrics• K-edge Imaging

– Angiography???

http://www.onlinetelemedicine.com/html/product/sam_images/Angiography.jpg

Project BackgroundProject Background

Monochromatic tunable X-ray:– Reduced radiation

dose to patient– Reduced contrast

agent concentrations

• K-edge imaging

FOR MORE INFO...

Free Electron Laser Laboratory http://www.vanderbilt.edu/fel/

Diagram of MX200’s laser paths and major elements.http://www.mxisystems.com/mx200.html

K-edge EffectK-edge Effect

Project GoalsProject Goals

Design a coronary phantom Test contrast agent concentrations

– hypersensitivity reaction to iodine (3-12% patients)

– current clinical dilution is 1:16

– using monochromatic plain films it is possible to see 1:256 dilutions

Determine optimal angle for stereo imaging

θ30”3”

Tan θ = 3/30 = 0.10

θ ~ 6°

Solution DescriptionSolution Description

Radio Translucent at 35 keV

Flexible material– Fluid perfusion

Phantom Size– 7.5cm diameter

Vasculature – Size Range 5 - 1 mm– Coronary arteries on

surface– Curved channels– Hollow vessels

Finger imaged at

19 keV

Finger imaged at

26 keV

Phantom DesignsPhantom Designs

Ball-3.exe

Shelley Medical Imaging Technologies www.simutech.com

Preliminary Sketch

SolidWorks Model

Material ConsiderationsMaterial Considerations

Ideal Material– ReoFlex™ 20 polyurethane

resin Actual Material

– Z-Corp’s ZP 102 plaster-based powder

– Compatible with printing machine used for prototyping process

– Ideal for printing fine-detail or thin-walled models

– Radiotranslucent and flexible formulation

– Option to infiltrate with Synair Corporation Por-A-Mold polyurethane resin

ScheduleSchedule

FOR MORE INFO...

http://vubme.vuse.vanderbilt.edu/srdesign/2003/group12/NCIIA%20Grant%20Proposal.htm

November December January February March April

Research Research

Material Testing &

Design

Material Testing &

Design

ManufacturingManufacturing

TestingTesting

Current StatusCurrent Status

Work Completed– Design Finalized– Manufacturer Contacted– Prototype Being Made

• Expected by Early Next Week

Future PlansFuture Plans

April– Create Pump for Dosimetry Testing– Start Testing

• Test Dosimetry for Imaging• Test for Optimal Stereo Angle

– Write Final Report– Create Poster

TestingTesting

Create Pump for Dosimetry TestingRun Tests

– Test Dosimetry for Imaging• Acquire series of images with different

dilutions of contrast agent

– Test for Optimal Stereo Angle• Acquire series of images at different

rotation angles

Team and ResourcesTeam and Resources

Advisor: Dr. Frank Carroll, M.D. Monochromatic x-ray machine W.M. Keck Free-electron Laser (FEL) Center at Vanderbilt University Materials and tools provided by BME Department and FEL Center

– Polyurethane resins from outside contractors

Photograph of device with laser cover removed

http://www.vanderbilt.edu/fel/Xray/manuscripts/final%20report%20for%20ONR%20grant%2020021218.doc

Questions?Questions?

Home