contraccion muscular udla
TRANSCRIPT
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Estructura del tejido muscular
esquelético.
Configuración de la célula muscular.
Estructura molecular del sarcómero.
Unión neuromuscular y sinapsis
neuromuscular.
Fenómeno de excitación –
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Nunca consideres el
estudio como una
obligación, sino
como una
oportunidad para
penetrar en el bello
y maravilloso mundo
del saber.
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Nucleus
Muscle fiber
(cell)
Striations
Skeletal muscle
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Depósitos
EnergéticosCorrientes
Iónicas
AMP/ATP [Ca2+]i
Switch Metabólico [Utilización de Sustratos
Energéticos]
Expresión Génica [Adaptación Estructurales y
Funcionales]
Contracción Muscular
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Vaina de
mielina
Fibra Muscular
La unión neuromuscular
consiste en la sinapsis
entre el botón terminal
del axon y la placa
motora del sarcolema de
la fibra muscular.
Arbolización Terminal
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Placa motora
Terminaci
ón
Axonal
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Vesícula
s
Sináptic
as
Espaci
o
Sinapti
coMembrana
Postsinápt
ica
Receptores
Nicotínicos
Membrana
Presinapti
ca
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Postsynaptic
cell
Synaptic
vesicle
Action
potential
Axon
terminal
An action potential depolarizes
the axon terminal.1
1
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Voltage-gated
Ca2+ channel
Postsynaptic
cell
Ca2+
Ca2+
Synaptic
vesicle
Action
potential
Axon
terminal
An action potential depolarizes
the axon terminal.
The depolarization opens voltage-
gated Ca2+ channels and Ca2+
enters the cell.
1
2
1
2
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Voltage-gated
Ca2+ channel
Postsynaptic
cell
Ca2+
Ca2+
Docking
protein
Synaptic
vesicle
Action
potential
Axon
terminal
An action potential depolarizes
the axon terminal.
The depolarization opens voltage-
gated Ca2+ channels and Ca2+
enters the cell.
Calcium entry triggers exocytosis
of synaptic vesicle contents.
1
2
3
1
2
3
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Voltage-gated
Ca2+ channel
Postsynaptic
cell
Ca2+
Ca2+
Docking
protein
Synaptic
vesicle
Action
potential
Axon
terminal
Receptor
An action potential depolarizes
the axon terminal.
The depolarization opens voltage-
gated Ca2+ channels and Ca2+
enters the cell.
Calcium entry triggers exocytosis
of synaptic vesicle contents.
Neurotransmitter diffuses across
the synaptic cleft and binds with
receptors on the postsynaptic cell.
4
1
2
3
4
1
2
3
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Voltage-gated
Ca2+ channel
Postsynaptic
cell
Ca2+
Ca2+
Docking
protein
Synaptic
vesicle
Action
potential
Axon
terminal
Receptor
An action potential depolarizes
the axon terminal.
The depolarization opens voltage-
gated Ca2+ channels and Ca2+
enters the cell.
Calcium entry triggers exocytosis
of synaptic vesicle contents.
Neurotransmitter diffuses across
the synaptic cleft and binds with
receptors on the postsynaptic cell.
Cell
response
Neurotransmitter binding initiates
a response in the postsynaptic
cell.
4
5
1
2
3
4
5
1
2
3
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Skeletal muscle
fiber
AChE
Action potential
ACh Acetyl + choline
Nicotinicreceptor
Motor endplate
Somatic motorneuron
Axon terminal
Voltage-gatedCa2+ channel Ca2+
Ca2+
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Figure 11-13b
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Skeletal muscle
Muscle fascicle:
bundle of fibers
Muscle fiber
Connective tissueConnective tissue
Tendon
Nerve and
blood vessels
Nucleus
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II aI
II b
• Fibras I // oscuras // mioglobina y enzimas oxidativas //
• Fibras II // claras // enzimas glicolíticas //
–II a // enzimas glicolíticas y oxidativas //
–II b // enzimas glicolíticas //
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FT 1
FT 2 b
FT 2 a
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Mitochondria
Myofibril
Thick
filament
Thin
filament
T-tubules
Sarcoplasmic
reticulum
Sarcolemma
Nucleus
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Sarcolemma
Thin filament
Thick filament
Triad Terminal
cisterna
T-tubule brings action
potentials into interior
of muscle fiber.
Sarcoplasmic reticulum
stores Ca2+.
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Myofibril
(c) A band
Z disk
I bandM line
H zone
Z disk
Sarcomere
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SarcomereA band
(a)
I band H zone I band
Z diskZ diskM line
Thick
filament
Thin
filament
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Z disk Z disk
Titin
M line
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Z disk
M line
Z disk
MyosinTitin provides
elasticity and
stabilizes myosin.
ActinNebulin helps
align actin.
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Myosin tail
Myosin heads
Myosin molecule
(e)
Thick filaments
Hinge
region
M line
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Thin filaments
Tropomyosin
Troponin
Actin chain
G-actin molecule
(f)Titin
Nebulin
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Skeletal muscle
fiber
AChE
Action potential
ACh Acetyl + choline
Nicotinicreceptor
Motor endplate
Somatic motorneuron
Axon terminal
Voltage-gatedCa2+ channel Ca2+
Ca2+
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Muscle fiber
Motor end plate
AChAxon terminal of
somatic motor neuron
Sarcoplasmic reticulum
Actin
Troponin
Tropomyosin
Myosin
head
Z disk
Myosin thick filament
M line
T-tubule
DHP
receptor
Ca2+
Somatic motor neuron
releases ACh at neuro-
muscular junction.
(a)
1
1
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Muscle fiber
Motor end plate
AChAxon terminal of
somatic motor neuron
Sarcoplasmic reticulum
Actin
Troponin
Tropomyosin
Myosin
head
Z disk
Myosin thick filament
M line
T-tubule
DHP
receptor
Ca2+
Somatic motor neuron
releases ACh at neuro-
muscular junction.
Net entry of Na+ through ACh
receptor-channel initiates
a muscle action potential.
Na+
K+
(a)
potential
1 2
1
2 Action potential
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(b)
Action potential in
t-tubule alters
conformation of
DHP receptor.
3
3
Ca2+
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Ca2+
Ca2+
released
(b)
Action potential in
t-tubule alters
conformation of
DHP receptor.
DHP receptor opens Ca2+
release channels in
sarcoplasmic reticulum
and Ca2+ enters cytoplasm.
3 4
3
4
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Ca2+
Ca2+
released
(b)
Action potential in
t-tubule alters
conformation of
DHP receptor.
DHP receptor opens Ca2+
release channels in
sarcoplasmic reticulum
and Ca2+ enters cytoplasm.
Ca2+ binds to troponin,
allowing strong actin-
myosin binding.
3 4 5
3
4
5
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M line
Ca2+
Ca2+
released
Myosin thick filament
(b)
Action potential in
t-tubule alters
conformation of
DHP receptor.
DHP receptor opens Ca2+
release channels in
sarcoplasmic reticulum
and Ca2+ enters cytoplasm.
Ca2+ binds to troponin,
allowing strong actin-
myosin binding.
Myosin heads execute
power stroke.
3 4 5
6
3
4
5
6
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M line
Ca2+
Distance actin moves
Ca2+
released
Myosin thick filament
(b)
Action potential in
t-tubule alters
conformation of
DHP receptor.
DHP receptor opens Ca2+
release channels in
sarcoplasmic reticulum
and Ca2+ enters cytoplasm.
Ca2+ binds to troponin,
allowing strong actin-
myosin binding.
Myosin heads execute
power stroke.
Actin filament slides
toward center of
sarcomere.
3 4 5
6 7
3
4
5
6
7
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Pi
Pi
ADP
ADP
G-actin moves
Cytosolic Ca2+
Tropomyosin shifts,
exposing binding
site on G-actin
TNTN
Power stroke
TroponinG-actin
Tropomyosin
blocks binding
site on G-actin
Myosin head
(b)(a) Initiation of contractionRelaxed state
Ca2+ levels increase
in cytosol.Ca2+ binds to troponin.
Troponin-Ca2+ complex
pulls tropomyosin away
from G-actin binding site.
Myosin binds to actin and
completes power stroke.
Actin filament moves.
3
4
3 4
1 2
1
2
5
5
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PiADP
TN
TroponinG-actin
Tropomyosin
blocks binding
site on G-actin
Myosin head
(a) Relaxed state
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PiADP
G-actin moves
Cytosolic Ca2+
Tropomyosin shifts,
exposing binding
site on G-actin
TN
Power stroke
(b) Initiation of contraction
Ca2+ levels increase
in cytosol.Ca2+ binds to troponin.
Troponin-Ca2+ complex
pulls tropomyosin away
from G-actin binding site.
Myosin binds to actin and
completes power stroke.
Actin filament moves.
3
4
3 4
1 2
1
2
5
5
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ADP
Cytosolic Ca2+
Ca2+ levels increase
in cytosol.1
1
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ADP
Cytosolic Ca2+
TN
Ca2+ levels increase
in cytosol.
Ca2+ binds to
troponin.
1
2
1
2
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ADP
Cytosolic Ca2+
Tropomyosin shifts,
exposing binding
site on G-actin
TN
Ca2+ levels increase
in cytosol.
Ca2+ binds to
troponin.
Troponin-Ca2+
complex pulls
tropomyosin
away from G-actin
binding site.
1
2
3
1
2
3
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ADP
Cytosolic Ca2+
Tropomyosin shifts,
exposing binding
site on G-actin
TN
Power stroke
Ca2+ levels increase
in cytosol.
Ca2+ binds to
troponin.
Troponin-Ca2+
complex pulls
tropomyosin
away from G-actin
binding site.
Myosin binds
to actin and
completes power
stroke.
1
2
3
4
1
2
3
4
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PiADP
G-actin moves
Cytosolic Ca2+
Tropomyosin shifts,
exposing binding
site on G-actin
TN
Power stroke
Ca2+ levels increase
in cytosol.
Ca2+ binds to
troponin.
Troponin-Ca2+
complex pulls
tropomyosin
away from G-actin
binding site.
Myosin binds
to actin and
completes power
stroke.
Actin filament
moves.
1
2
3
4
5
1
2
3
4
5