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TRANSCRIPT
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Monitoring for Opioid Induced Respiratory Depression: Paradigm Shift from Threshold
Monitoring to Trend Monitoring
Carla R. Jungquist, ANP‐BC, PhD
Assistant Professor University at Buffalo
J. Paul Curry, MD
Past Chief of Staff Hoag Memorial Hospital and Clinical Professor UCLA Dept. Anesthesiology
Conflict of Interest Disclosure
• Authors Conflicts of Interest:
– A. Jungquist – Serve as expert witness for cases of personal
injury or death from opioid induced respiratory depression
– B. Curry – Consultant with Lyntek Medical Technologies that
holds patents on real‐time advanced clinical pattern recognition
Objectives
• Describe current monitoring practices and possible legal consequences from adverse events
• Describe the physiology of respiration as it relates to identifying impending respiratory depression
• Identify disease and conditions associated with increased risk of opioid induced respiratory depression
• Describe best practices for the use of electronic monitoring.
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Why we care
• Postoperative hypoxemia, defined as oxygen saturation (SpO2) below 90%, is a multifactorial problem affecting as many as 76% of our patients. (Curry, 2003)
• Opioid‐related adverse events in post‐surgical populations is associated with: – increased length of hospitalization
– greater hospital costs
– higher likelihood for 30‐day readmissions
– higher mortality rates
Why we care
• In an extensive review of 24 legal cases associated with Obstructive Sleep Apnea that went to jury decisions, all cases (11) that occurred on post surgical units involved opioids and resulted in either severe anoxic brain injury or death.
• Settlements ranged from $650,000 ‐ $7.7 million.
• The incidence has been progressively increasing since 1991.
(Fouladpour , 2015)
How Nurses Recognize Patients at Risk
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2009 & 2013 Monitoring Practices
High Risk Only All Patients2013 (n=102) 2009 (n=90) 2013 (n=102) 2009 (n=90)
Intermittent Pulse OximetryEpidural 30% 21% 38% 36%IV PCA 36% 22% 42% 36%Oral/IV 34% 20% 40% 37%
Continuous Pulse OximetryEpidural 41% 25% 37% 31%IV PCA 41% 32% 28% 20%Oral/IV 17% 27% 5% 13%
End Tidal Carbon DioxideEpidural 10% 6% 7% 2%IV PCA 14% 8% 11% 2%Oral/IV 8% - 1% -
Use of sedation scales
2013 (n=102) 2009 (n=90)
Pasero Opioid Scale 53% 21%
Aldrete Scale 39% 30%
Ramsey Scale 17% 15%
Modified Ramsay Scale 13% 13%
Richmond Agitation-Sedation Scale 42% 12%
Riker Scale/Modified Riker Scale 6% 8%
Scale developed at your institution 8% <1%
Motor Activity Assessment Scale 1% <1%
Glasgow Coma Scale 37% <1%
University of Michigan Scale 4% <1%
Best Practice for IV PCA
• Every 2.5 hours for the first 24 hours:
– respiratory rate
– level of sedation and
– SpO2 with pulse‐oximetry
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2012 Hospital Practice
• Comparing Best Practice to the hospital monitoring practices, we found that:
– 8.3% of the patients on opioid IV PCA were being monitored per best practice.
• If we changed the timeframe to every 4.5 hours
– 26.8% of the patients were monitored using the 3 parameters of RR, PO, SS.
Scratch, the Cat
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Orion, the Hunter
Review of respiratory physiology
Review of respiratory physiology
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Three Patterns Of Respiratory Dysfunction
Type I
A healthy male who had just undergone elective surgery develops shortness of breath that’s noticed by his family who express concern to the nurse. The nurse, citing a normal oxygen saturation reading on his oximeter, reassures the family that the monitor indicates he’s okay. Eventually his respiratory rate does rise to a critical value, but by this time it’s too late to effectively respond to his rapidly deteriorating clinical condition and the patient, with sepsis, dies.
Framework of three patterns of respiratory dysfunction
Three patterns of respiratory dysfunction
Type II
A healthy female who is receiving routine post–op nasal oxygen has been up all night complaining of severe post‐op pain, but is now finally asleep after yet another dose of IV opioid. The nurse, noticing on rounds the patient’s oxygen saturation is ‘perfect’ on the monitor, decides not to awaken her. She is found dead in bed 4 hours later.
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Framework of three patterns of respiratory dysfunction
Math Counts!
• The alveolar gas equation: [PA02 = FIO2(PATM‐PH2O) – PaCO2/RQ]
• PAO2‐PaO2 (A‐a gradient) = (Pt. age + 10)/4
• Henderson‐Hasselbach equation (pH=6.1+log(HCO3/(0.03xPaCO2))
• Automated mathematical models like HbO.Dash are used by blood gas laboratories, correlating reliable saturation values off any known PaO2
How Nurses Recognize Patients at Risk
Simulated SPO2 values associated with FIO2 and PaCO2/arterial pH
FIO2 PaCO2
55mmHg (pH 7.26)
Oximeter 90% alarm breach
SPO2
driftPaCO2
70mmHg(CO2
Narcosis)
Oximeter 90% alarm breach
SPO2
drift
30yo Patient Model.21 SPO2 91% ‐ + + +
.24 SPO2 95% ‐ ‐ SPO2 89% + +
.27 ‐ ‐ SPO2 93% ‐ +
.30 SPO2 98% ‐ ‐ SPO2 95% ‐ ‐
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How Nurses Recognize Patients at Risk
Simulated SPO2 values associated with FIO2 and PaCO2/arterial pH
FIO2 PaCO2
55mmHg (pH 7.26)
Oximeter 90% alarm breach
SPO2
driftPaCO2
70mmHg(CO2
Narcosis)
Oximeter 90% alarm breach
SPO2
drift
50yo Patient Model.21 SPO2 89% + + + +
.24 SPO2 94% ‐ + SPO2 87% + +
.27 ‐ ‐ SPO2 93% ‐ +
.30 ‐ ‐ SPO2 95% ‐ ‐
How Nurses Recognize Patients at Risk
Simulated SPO2 values associated with FIO2 and PaCO2/arterial pH
FIO2 PaCO2
55mmHg (pH 7.26)
Oximeter 90% alarm breach
SPO2
driftPaCO2
70mmHg(CO2
Narcosis)
Oximeter 90% alarm breach
SPO2
drift
75yo Patient Model.21 SPO2 87% + + + +
.24 SPO2 93% ‐ + SPO2 84% + +
.27 SPO2 96% ‐ ‐ SPO2 91% ‐ +
.30 ‐ ‐ SPO2 95% ‐ ‐
Framework of three patterns of respiratory dysfunction
Type III
An otherwise healthy male with unrecognized sleep apnea receives a post‐operative opioid. His alarm sounds repeatedly but lasts only for about 30 seconds before it stops, only to repeat again and again. When the nurse awakens the patient he feels fine and is completely alert, asking for more pain medication, which the nurse gives in a normal dose. The nurse, suffering from alarm fatigue, stops responding to the same alarming. Later that night the patient is found dead in bed.
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Framework of three patterns of respiratory dysfunction
Framework of three patterns of respiratory dysfunction
Pulse Oximetry
• Perhaps all patients in the first 48 hours post‐op should be continuously monitored, but remember…we have a lot of patients on IV opioids for acute pain control that are not undergoing a procedure. Patients are in the hospital because they need us to take care of them!!! Letting your patient “get a good night of sleep” is not taking good care of them.
• Intermittent – timing and technique is the problem
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Respiration is the most vulnerable during sleep
We missed the desaturations!!
What is wrong with this picture???
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ETCO2
Minute Volume
Recommendations for best monitoring practices
• Regardless of the type of electronic monitoring or nurse monitoring, the most important point I want you to take from this talk is that patient’s have individual response to opioids and the only way we will be able to figure out if they are in trouble is to compare their parameters to their baseline.
• Keep in mind the different patterns of dysfunction. Know your patient’s risks and how best to provide safe and effective pain control.
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References
1. Samuels & Rabinov (1986 ) Difficulty Reversing Drug‐induced Coma in a Patient with Sleep Apnea. Anesthesia‐Analgesia.
2. Khoo, Mukherjee, Phua & Xia Shi (2009) Obstructive Sleep Apnea Presenting as Recurrent Cardiopulmonary Arrest. Sleep Breath.
3. APSF NEWSLETTER (2002) Sleep Apnea and Narcotic Postoperative Pain Medication: A Morbidity and Mortality Risk.
4. Chung et al. (2015) Postoperative Sleep‐Disordered Breathing in Patients Without Preoperative Sleep Apnea: Anesthesia‐Analgesia.
5. Taenzer, Pyke, McGrath, Blike (2010) Impact of Pulse Oximetry Surveillance on Rescue Events and Intensive Care Unit Transfers: Anesthesiology.
6. Foulapour, Jesudoss, Bolden, Sharman, & Auckley (2015) Perioperative Complications in Obstructive Sleep Apnea Patients Undergoing Surgery: A Review of the Legal Literature. Anesthesa‐Analgesia.
7. Jarzyna, D., Jungquist, C.R., Pasero, C., Willens, J.S., Nisbet, A., Oakes, L., Dempsey, S., Santangelo, D., & Polomano, R.C.(2011). American society for pain management nursing: Expert consensus panel on monitoring for opioid‐induced sedation and respiratory depression. Journal of Pain Management Nursing, 12(3), 118‐145.
8. Willens J, Jungquist CR, Polomano, R (2013) ASPMN Monitoring Survey Results, Journal of Pain Management Nursing, available online 1/2013. http://dx.doi.org/10.1016/j.pmn.2013.01.002
9. Jungquist CR, Willens JS, Dunwoody DR, Klingman KJ, Polomano RC (2013) Monitoring for Opioid Induced Advancing Sedation and Respiratory Depression: ASPMN membership survey of current practice. Pain Management Nursing. Available online May, 2014. Vol 14, No 1 (March), 2013: pp 60‐65. http://dx.doi.org/10.1016/j.pmn.2013.01.002.
10. Jungquist CR, Pasero C, Tripoli N, Gorodetsky R, Metersky M, Polomano RC (2014) Instituting Best Practice for Monitoring for Opioid Induced Advancing Sedation in Hospitalized Patients. Worldviews on Evidence Based Nursing. 00:00, 1‐11. Available online 9/24/14.
11. Curry JP, Jungquist CR (2014). A critical assessment of monitoring practices, patient deterioration, and alarm fatigue on inpatient wards: a review. Patient Safety in Surgery. 2014, 8:29 http://www.pssjournal.com/content/8/1/29.