©cmbi 2005 bioinformatics new integrating across borders problem oriented theory and practice not...
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©CMBI 2005
Bioinformatics
NewIntegratingAcross bordersProblem orientedTheory and practiceNot very difficult…
©CMBI 2005
Bio + informatics
©CMBI 2005
Bioinformatics examples
Analysis of the information content of genomes
Sequence analysis and sequence alignment
Most computational aspects of drug design
Data mining in biological databases
Model macromolecular structures/complexes
Biological pathway analysis
Phylogeny
©CMBI 2005
The human genome
©CMBI 2005
Human genome
....acccaa gaagtcagaa tcctcgaagc tgaagcctga ctgtaagctc tgcctcctac
aactagacaa gtcacaatgc aacccctttg ctccagagga aaaggagtaa gcacagaggg
cttctgagtc cggcaatgct ccatttcctg acaggagcat tttacagact tgcgtctgcc
cctctgaggg aggcagggcc atcagctaac actcagagac aaggatggtc ctacaacatc
ctgatctggg aggaagaggt gaaggcaact caccaccctc aggcatctta acagaaaaca
gtggaactaa ggctcattct aaagaatgtg cccaagatca cacaccgaag gctgcaaagc
gagagtcaaa cttggaaccc tgaacctgca cttgtccctt tacactgccc tgcagcatgg
atgcgatggc tgggcagagg gaagtgccca agcctgggga caaaaatgcc tacctg....
©CMBI 2005
Genome annotation
©CMBI 2005
Bioinformatics and medicine
The human genome will be known and properly annotated in a few years.
At that moment we know nearly all targets for medicines.
©CMBI 2005
Chromosomes
©CMBI 2005
Goals for medicine and pharma
©CMBI 2005
Bioinformatics and medicine
Parasite
Active site
©CMBI 2005
Bioinformatics and medicine
©CMBI 2005
GPCR: Thé target for drug design
©CMBI 2005
Drug Design
©CMBI 2005
Single Nucleotide Polymorphism
SNPs (“snips”): Naturally occurring variants that affect a single nucleotide.
Occurrence: once in every 300-1000 bases.
SNPs are responsible e.g. for hair colour, but are also the reason for individual differences in respons to drugs.
©CMBI 2005
Plant/Animal improvement
©CMBI 2005
Protein engineering
©CMBI 2005
Molecular graphics
If you don't think that pictures are the best way to communicate, I suggest you go home, and watch your radio.
©CMBI 2005
Molecular graphics
©CMBI 2005
Molecular graphics
Some mutations found in the P63 model reduce its DNA binding capacity
P63 is a P53 homologue
©CMBI 2005
Data and databases
©CMBI 2005
Sequences
Sequence alignment is the best tool for transferring information from a well studied molecule to a novel, unknown, or less well studied molecule.And this topic, transfer of information, will be the main topic of this course.