CLARENCE ERNEST SCHUTTDEPARTMENT OF CHEMISTRYPRINCETON UNIVERSITY(609) 258-4435 (O)/ (617) 866-0024(C)SCHUTT@PRINCETON.EDU ; SCHUTT@NLMFOUNDATION.ORG

EDUCATION The University of Michigan, 1967, BS (Physics) Honors Program,

Michigan State University, 1969, MS (Physics)

Harvard University, 1976, Ph.D. (Applied Mathematics)Thesis: The Structure of Tomato Bushy Stunt Virus to 5.5 Å

ResolutionResearch Advisor: Prof. Stephen C. Harrison

EMPLOYMENT HISTORY Director and Chief Scientific Officer, Nancy Lurie Marks Family Foundation

(2008 - present)

Professor of Chemistry, Princeton University (1995 – 2012)

Associate Professor of Chemistry, Princeton University (1985 - 1995)

Post-doctoral Fellow, Medical Research Council Laboratory of Molecular Biology, Cambridge, England (1977-1985), Research Advisors: Sir Aaron Klug and Dr. Hugh Huxley

Graduate Research Fellow, Department of Biochemistry & Molecular Biology, Harvard University, Cambridge, Massachusetts (1972-1976)

Administration Manager, Aerospace America, Inc., Bay City, Michigan (1970-1971)

Physicist, Bendix Aerospace Systems Division, Ann Arbor, Michigan (1969-1970)

FELLOWSHIPS AND HONORS Honorary Professorship, University of San Marcos (Lima) (2009)Visiting Fellow Commoner, Trinity College, Cambridge University (2004-2005)Member, Physiological Chemistry Study Section of the NIH (1998 – 2001)Past Chairman of the Board, National Alliance for Autism Research (1999 - June 2001)J & J Focused Giving Award (1989 - 1991)Ph.D. honoris causa, Stockholm University, 1988

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Established Investigatorship, American Heart Association (1982 - 1987)Muscular Dystrophy Association Fellowship (1980 - 1982)Helen Hay Whitney Fellowship (1977 - 1979)General Motors College Scholarship (1963-1967)

SPECIAL ADVISORY CAPACITY Scientific Advisor, Nancy Lurie Marks Family Foundation (2002-2007) Member, Neurodiscovery Advisory Council, Harvard Medical School (2010-2012) Member, Vice-Chancellor’s Advisory Council, Oxford University (2010-2012)

ADVISORY BOARDSMember, Advisory Council, Department of Neuroscience, Harvard

Medical School (2010)Editorial Board, Phil. Trans. Roy. Soc. B (2007-2010)Board Member, Center for Jewish Life, Princeton University,

(September 2006 -2009)Founder and Co-Chair, Princeton-Eden Lecture Series (1994 - present)Member, External Review Committee, St. Jude Children’s Research Hospital (October 2001) Chairman, Scientific Advisory Board, NitroSystems, Inc., GA (1998- 2003) Member, NIH-Physiological Chemistry Study Section, (1997- 2000)Chairman, Scientific Advisory Board, DGI Technologies Inc, Upper Montclair, NJ (1994 -2003)Founding Trustee & Chairman, National Alliance for Autism Research,

Princeton, NJ (1995 –2001)Member, Scientific Advisory Board, 3-D Pharmaceuticals, Inc., Exton, PA

(1993 -2003)Advisory Committee for Brookhaven National Light Source for Protein Crystallography, (1991 - 1998)

RESEARCH GROUP

POSTDOCTORAL FELLOWS:

Nancy Vogelaar (1990-1996)Michael Rozycki (1987-1996)

Daniel Bollag (1990-1991)Anne Stock (1988-1990)

GRADUATE STUDENTS:

Alex Plakonatonakis, writing thesisVolodymyr Gelfand. “Quantitative Modeling of Muscle Contraction”, June 2003Kartik Narayan. “Towards an Atomic-Resolution Structure of Filamentous Actin”, January 2003

Constantine Kreatsoulas. “A Catalytic Polymerization Model for Actin-Based Motility” November 2002

Raj Chakrabarti. “PCR Enhancement by Organic Solvents”, June 2002. Ilana M. Nodelman. “Structural Analyses of Human Profilin IIB and Rotavirus NSP4” June 2001

Gregory D. Bowman. “A Structural Investigation of Actin Depolymerizing Factor 1 from Arabidopsis Thaliana” June 2001

Rebecca Page. “Domain Motions in Actin & their Implications for F-actin Modelling” (Department

of Chemistry). December 1999Donald Preston Huddler, Jr. “Structural Studies of Plant Profilins” (Department of Molecular

Biology). June 1999Ron Shigeta, Ph.D. 1996, “Structural Analyses of Pertussis Toxin and Profilin

I from Arabidopsis Thaliana.”

John Chik, Ph.D. 1996, “Solid-State Transformations of Crystalline Bovine Profilin:b-Actin

Complex at Atomic Resolution.”Nalin Goonesekere, Ph.D. 1994, "The Crystal Structure of Profilin."Katrina Forest, Ph.D. 1993, "X-Ray and Electron Crystallography Applied

to Pertussis Toxin."James Myslik, Ph.D. 1992, "The Structure of Actin in the Crystalline

Profilin:Actin Complex."Roberta Susnow, Ph.D. 1991, "Quantitative Biomolecular Structural

SensitivityAnalysis," (Advisors: C. E. Schutt and H. Rabitz)

Joanna Krueger, Ph.D. 1991, "Structure/Function Studies of the Methylesterase

Involved in Bacterial Chemotaxis."Vidya Raghunathan, Ph.D. 1991, "Study of Profilin Conformation: Effects of

Phosphatidylinositol."Malini Raghavan, Ph.D.1991, "The Use of Alternative Substrates in the

Characterization of Actin and CarnosineMethylating Enzymes."Nicholas Strauss, Ph.D. 1987, "X-ray Crystallographic Studies on the

Structure and Interactions of the Profilin:Actin Complex." (Cambridge

University)

COURSES TAUGHT

Chemistry 981 Junior Independent Study Seminar (Fall,2011, 2012)Chemistry 543 Structural Biology of Neurodevelopmental Disorders

(Spring 2009, 2010)Chemistry 215 Honors Freshman Chemistry (Fall 2009, 2010)Chemistry 231-232 Integrated Science Course (Spring 2006, 2007, 2008; Fall 2006, 2007))Chemistry 306 Thermodynamics & Kinetics (Spring 2003, 2004, 2008)

Woodrow Wilson School 474 Special Topics in Public Affairs: Pharmaceutical Research, Drug Approval, and Health Policy (Fall 2002-2006) – re-numbered WWS327 Chemistry 543 Structural Biology of the Human Nervous System (Spring 1999) Senior Seminar: Consilience: Case Studies in Complex Adaptive Systems (Fall 1998) Chemistry 508 Biophysical Chemistry (Fall 1997)Freshman Seminar (FRS119) Symmetry and Chance in Biology (Fall 1996)Chemistry 542 Principles of Macromolecular Structure (Spring 1996) Freshman Seminar (FRS118) Architectonics of Nature (Spring 1996) Chemistry 543 Structural Biology of Human Disease (Spring 1994,

1997; Fall 1994; Fall 1995)Senior Seminar: Complex Adaptive Systems (1993)Chemistry 543 Advanced Crystallography (1993) Freshman Seminar: Change and Transformation in the Material World

(1991, 1992) Chemistry 201 Introductory Chemistry (1989 – 1993, 1997-2001) Chemistry 205 Honors Freshman Chemistry (1987 - 1988)Chemistry 542 Principles of Macromolecular Structure (1987 - 1990)

CONFERENCES ORGANIZED Wenner-Gren Symposium, “Force Transduction in Biological Systems”,

Stockholm, Sweden, August 2004Princeton Class of 1943, "The Amazing Human Mind" Reunion

Symposium, Princeton University, May 29, 1998Princeton 250th Anniversary Symposium “The Architectonics of Nature”,

Princeton University, November 1996

The Eden Institute Foundation Princeton Lecture Series on Autism, “Affecting the Research and Service Agenda,” Princeton, NJ. Annually May 1995-June 2009

Frontiers in Structural Biology: in honor of D. L. D. Caspar’s 60th birthday, Princeton University, May 1986

NSF/NIH SCIENTIFIC REVIEWS (SELECTED)

Member, N.I.H., Physiological Chemistry Study Section, (1996-2000)

COMMITTEES

Associated Faculty of Molecular Biology Department, Princeton University Director, Graduate Program in Molecular Biophysics, Princeton University

(1992 -2002)Member, Program in Materials Science, Princeton University Executive Committee, Program in Neuroscience, Princeton University Director, Graduate Program of Chemistry Department, Princeton University

(1995 - 1997)Member, Summer Scholars Institute, Princeton University (1995 - 1998)

University Radiation Safety Committee (1987 – 1990, 1998 -2002)University Committee on Standings and Evaluations (1990 - 1991)Faculty Fellow, Forbes CollegeUndergraduate Class Advisor (1990 - 1991)University Committee, Public Lectures (1993)Director, Graduate Program of Chemistry Department, Princeton University

(1995 - 1997)Member, Council of the Princeton University Community (2000 – 2002)Member, Faculty Advisory Committee on Policy (2001-2002)

Member, Faculty Advisory Committee, Program in Neuroscience (2006-2012)

UNDERGRADUATE THESIS DIRECTED

2011 Stephanie Noble, Modeling Filamentous Actin. Department of Chemical Engineering

2007 Lauren D. Pflepsen, Personalized Psychopharmacotherapy: A Model for Biomarker- Based Diagnosis and Optimized Treament of Schisophrenia.

. Tara L. Lloyd, Proton NMR Metabonomic Analysis of Blood Serum from

Pregnant Mares Grazing Endophyte-Infected Fescue.

Catherine E. Cushenberry, Redistributing Pharmacovigilance: Physicians and the Industry in U.S. Post-Market Drug Surveillance

2006 Sarah Murphy, Regulation of Molecular Interactions: Implications for Synaptogenesis &

Neurodevelopment.

Lauren F. Chaparro, Generation RX: The Science, Ethics, and Politics of Antidepressants in Pediatrics.

Andrew Goldstein, Public Scientific Literacy: A New Rationale Rooted in Individual Agency.

2003 Michael Bennett, Structural Studies on Tropomyosin Isoforms

2002 Jamie Chaft, Structural Studies on Rotaviral NSP4

1999 Natalie Audage. “Photoperiodic Effects on Brain GnRH and Area X Volume in Male

Canaries (Serinus canaria). Department of Chemistry.

Sulene Liu Chi. “Partial Construction of a Single-Chain Linked Actin Trimer”. Department

Of Chemistry.

Neal A. Desai. “Human Consciousness: A Philosophico-Scientific Theory”. Department

of Molecular Biology.

Sepander David Kamvar. “Muscle Contraction as a Markov Process”. Department of

Chemistry.

1997 Matthew Hassan, “Serotonin and the Synaptic Cytoskeleton.”

1996 Daniel Klebanov, "Analysis of Muscle Contraction through Computer Modeling.”

Kurt Thorn, "The Crystal Structure of Arabidopsis Profilin I at 1.6Å Phased by MAD

Analysis of the Selenomethionyl Protein."

1994 Jennifer Jones, "Purification and Preliminary Characterization of B. Verrucosa

Profilin."

Robert Smith, "Pertussis Toxin a Purification and Crystallization Study Augmented by ATPgS Precession Photography."

Senaka A. Peter, "Influence of sn-2 Chain Unsaturation on the 2H-NMR

Order Parameter Profiles and the Bilayer Thickness of Stearic Acid sn-1 Chains in Phosphatidylcholines."

1992 Stephen Miller, "Computer Simulation of the Actin Power StrokeModel of Muscle Contraction."

Kristin Anderson, "A Preliminary Analysis of Tubulin Stability andpH Dependence of the Tubulin Lattice." (Eng. Biol.)

Patrick Ying, "Basic Fibroblast Growth Factor and Sulfated

Polysaccharides:Development of A Binding Assay."

1991 Kevin Leong, "The Expression of Mammalian Profilin in Escherichia Coli:

Toward an NMR Structural Determination." (Eng. Biol.)

Thomas Cappola, "Investigating the Structure of ADP.Pi-Actin."

Alyssa Kuhn, "Purification, Crystallization and Preliminary X-ray Analysis

of Porcine Growth Hormone." (Eng. Biol.)

Daniel Elkes, "Evidence for Thymosin Beta-4 in Triton-Based Homogenate of

Calf Thymus." (Mol. Biol.)

1990 Thu Huong Le Trinh, "Purification and Crystallization of Gc."

1989 Leo Kwok-Yueh Shin, "Alchemy in Elizabethan England and Late Ming China."

Catherine Smith, "Post-Translational Modification of Actin."

Chinyu Su, "Induction and Partial Purification of Yeast Tubulin."

1988 Mona Gabbay, "Creativity in Science: Visual Perception of the Actin/Profilin

Electron Density Map." Elizabeth Hilton, "Actin Database: A Tool for Structural and Mechanistic Studies."

1987 Donna Czerniakowski,"Purification and Interaction of Gelsolin and Actin." Thomas Hawn, "Refinement of the Electron Density Map of the Actin:

Profilin Complex." Scott Garman, "Progress Toward the Determination of the Structure of

Profilin:actin Crystals." Stephen Kimatian, "Molecular Dynamics of the Lipid Micelle."

1986 Howard Chen "Molecular Graphics and Biology." (Chem Eng)

INVITED SEMINARS AND LECTURES

2012 “Implications of Autism Research for Global Health Policy”, 20 November, WWS

“Distinguished Lectureship”, Children’s Hospital, 17 December, Univ. Pennsylvania

2010

“Autism: Advancing Research, Diagnosis and Treatment, Massachusetts General Hospital, 9 April

“Eppley Lecture: Architectonics of Autism”, University of Nebraska Medical School, 22 April 2010

“Plenary Lecture: Why Now is the Time to Fund Adult Programs in Autism”, Interdisciplinary

Council on Development & Learning, Washington DC, 7 November 2010

2009 “Acceptance Lecture: Honorary Professorship”, University of San Marcos, Lima, Peru, 30 March

2008

“An Architectonic Perspective on Autism”, St. Peter’s College, 8 March 2008

“Because of Alex – Cancer Biology & Autism”, Princeton-Eden Lecture Series, 6 June, 2008

“The Structural Biology of Autism”, Brandeis University, 5 September 2008

2007“The Origins of Life: An Architectonic Perspective”, 28 March 2007, Nobel Forum: What is Life?, Karolinska Institute, Stockholm, Sweden

“An Architectonic Perspective on Autism: New Directions in Autism Research”, 25 September 2007, Brandeis University

“A Policy Perspective on the Pharmaceutical Industry”, 4 October 2007, The Wharton School, University of Pennsylvania

2006 “Because of Alex – Implications of Genomics for Autism Research”,

Princeton-Eden Lecture Series, June, 2006

“The Lima Lectures on Molecular Evolution: Origins of Life”, 1 August 2006, University of San Marcos, Lima, Peru.

“The Lima Lectures on Molecular Evolution: Origins of Eukaryotic Cells”, 2 August 2006, University of San Marcos, Lima, Peru.

“The Lima Lectures on Molecular Evolution: Origins of Multi-Cellularity”, 3 August 2006, University of San Marcos, Lima, Peru

“The Lima Lectures on Molecular Evolution: Evolution of the Brain and Communication by Speech, 4 August 2006, University of San Marcos, Lima, Peru

2005 “Actin Filament Modeling: Interpretation of Recent Results from Crystallography”, 26 Sept. 2005, Medical Research Council Laboratory of Molecular Biology, Cambridge, England

“The Path Forward for Autism Research & Philanthropy”, 26 Sept. 2005, Masters Lodge, Trinity College, Cambridge, England (after dinner speech)

2004 “Architectonics of Molecules”, 17 March 2004, University of San Marcos, Lima Peru

“How Molecules Create Thought”, 18 March 2004, University of San Marcos, Lima, Peru

“Art & Science”, 19 March 2003, University of San Marcos, Lima, Peru

“Beyond the Genome: Evolution of Special Physical Abilities”, 16 June 2004, Arts & Ideas Festival, New Haven, Conn.

“Structural Biology of Actin Filament Assembly: a new model for filament severing and capping by gelsolin”, Wenner-Gren Symposium, 18 August 2004, Stockholm, Sweden

2002“The Tango of Art & Science”, 19 Feb. 2002, The Newark Museum, Newark,

NJ

“Structural Biology and Human Disease”, 12 Feb. 2002, Uppsala, Sweden

“Structural Biology of Actin-Based Motility”, 25 Mar. 2002, Nano Architectonics International Symposium II, Los Angeles, CA

“Personalized Medicine and Structure of Protein Families”, 4 Dec. 2002, Genaissance Pharmaceuticals, New Haven, CT

2001“Because of Alex…scenarios for future without autism”, 8 June 2001 Keynote Address: “Teaching to Make a Difference”, Harold W. McGraw Jr.

Center for Teaching and Learning, Princeton, NJ

“Structural Biology of Autism”, National Institutes of Health/ACC, 8 September 2001, Bethesda, MD

“Genes, Genii and the Architectonics of Autism” FECA Conference, 6 November 2001, Westchester County, NY

2000MACC Lecture, "Gold in the Details", 18 September 2000

1999Fox-Chase Cancer Center, Philadelphia, PA “The Architectonics of Actin”, 18

March 1999

New York University Medical School, “The Architectonics of Actin”, 27 April 1999

Stockholm University, “Who does he think he is?” – Symposium on Actin and Chromatin

Remodeling in honor of Uno Lindberg’s 60th Birthday. 19 May 1999

Gordon Conference on Muscle Contraction, Session Chair and Speaker, “Actin Dynamics”,

Colby College, Andover, VT, 8 June 1999

Wyeth-Ayerst Lederle Vaccines Division, Rochester, NY “What Protein Crystallography Teaches us

About Protein Dynamics”. 25 August 1999

Eastern College (St. Davids, PA), “The Architectonics of Nature”, Inaugural Lecture, Templeton

Honors College, 17 September 1999

University of California, Santa Barbara, “Because of Alex… Scenarios for a Future without

Autism”, Plenary Lecturer. Symposium on “Autism 2000: Focus on Solutions”, 24 September 1999

University of Toledo, Annual Distinguished Lecturer of Department of Chemistry, “The Nature of

Actin” – 17 November 1999. Special Public Lecture in Honor of the Installation of Dr. Vic

Kapoor as President of Toledo University – “Architectonics” – 18 November 1999

1998

The Princeton Section of the American Chemical Society, “Protein Architectonics,” Princeton, NJ, January 15

Autism Society of America, Oakland County Chapter, “Because of Alex... My Odyssey from Denial

to NAAR,” West Bloomfield, MI, January 25

Vanderbilt University, “Architectonics of Actin”, Nashville, TN, February 10

Chapel Hill Autism Group, Chapel Hill, NC, February 23

University of Toronto, "Muscle Contraction as a Markov Process," Toronto, Canada, February 26

Princeton Plasma Physics Laboratory, "The Architectonics of Living Molecules," March 7

Fetzer Institute, "Architectonics: Actin, Autism and Art," Kalamazoo, MI, March 24-27

The Eden Institute Foundation Princeton Lecture Series on Autism, “Because of Alex...,” Princeton, NJ, May 15

The Amazing Human Mind Reunion Symposium, "Architectonics of the Mind," Princeton, May 29 1997

Florida State University, “Muscle Contraction as a Markov Process”, Tallahassee, FL, January 10-11

Lederle Vaccines Group, “Collaborative Challenges for Drug Discovery in the Age of

Bioinformatics,” Pearl River, NY, February 18

Rockefeller University, “The Structural Biology of Actin-Binding Proteins”, New York, NY,

Feb. 24-25Wyeth-Ayerst, “The Structural Biology of Actin-Binding Proteins”, Princeton,

NJ, March 5

The Eden Institute Foundation Princeton Lecture Series on Autism, “Because of Alex...,” Princeton, NJ, May 23

The University of Michigan, Department of Biophysics, “The Architectonics of Actin"

Ann Arbor, MI, December 17

1996Parke-Davis Pharmaceuticals, Workshop in Structural Biology, Ann Arbor, MI,

Feb. 16 “Nurturing the Biochemistry-Crystallography Interface” “Nurturing the Crystallography-Chemistry Interface” “Some Case Histories of Successful Structural Collaborations”

Dupont Agricultural Products, “Gerald Edelman’s Theory of Neural Darwinism,” Wilmington, DE, March 20

Delaware Valley Enzymology Club, “The Nature of Actin”, Wilmington, DE, March 20

The Eden Institute Foundation Princeton Lecture Series on Autism, “Because of Alex...,” Princeton, NJ, May 24

COSAC Annual Meeting, “The Future of Biomedical Research in Autism,” New Brunswick,

NJ, April

The Autism Society of America, “The Structural Biology of Autism,” Los Angeles, CA, April 27

Morehouse College, “The Nature of Actin: Its Role in Generating Force in Muscle and Non-muscle Cells as Revealed by High Resolution X-ray Crystallography,” Atlanta, GA October 22

1995

FMC, “The High Resolution Crystal Structure of the Profilin:Actin Complex and its

Implications for Cell Motility and Muscle Contraction,” Princeton, NJ, Jan 24

Wyeth Ayerst, “Structural Biology of the Immune System,” Princeton, NJ, Jan 25

Parke-Davis, “The High Resolution Crystal Structure of the Profilin:Actin Complex and Its

Implications for Cell Motility and Muscle Contraction”, Ann Arbor, MI, Feb 14

Stockholm University, “Structural Biology and Human Disease,” Stockholm, Sweden,

March 14-17.

10th Meeting of the European Cytoskeletal Forum, Stockholm, Sweden, May 27-31

Dupont Agricultural Products Analytical Panel Discussion, Wilmington, DE, April 21

The Eden Institute Foundation Princeton Lecture Series on Autism, “Because of Alex...”,

Princeton, NJ, May 19Twenty-First EMBO Annual Symposium, "Structure and Function of

Proteins," Heidelberg, Germany, September 24-28

Workshop on “The Creative Process in Molecular Science I,” Dupont Agricultural Products

Division, Wilmington, DE, October 14-15

Workshop on “The Creative Process in Molecular Science II,” Dupont Agricultural Products

Division, Wilmington, DE, November 14-15

American Chemical Society, “Graduate Program in the United States,” Columbia

University, NY, November 18-19

1994Scripps Research Institute, "The Structure of Crystalline Profilin:b-Actin and

its Implications," La Jolla, CA, January 27

Stockholm University, "Structural Biology and Human Disease," Stockholm, Sweden, February 4 - 9

Eden Institute, " Research Perspective on Autism," Princeton, NJ, February 21

Southwestern Medical Center, Molecular Biophysics Program, "The Structure of Crystalline

Profilin:b-Actin and its Implications," The University of Texas, Dallas, TX, April 12

Workshop on "Molecular Imaging of Cytoskeleton Protein Assembly," Baylor Medical

College, Houston, TX, April 29 - May 4

Wistar Institute, "A Unified View of the Role of Actin in Muscle and Non-muscle

Motility: Lessons from Crystal Structures of Profilin:Actin and Profilin," Philadelphia, PA, October 19

Seventh Biophysical Discussions, "Structural Studies on the Ribbon-To-Helix Transition in Profilin:Actin Crystals," Airlie House, VA, October 21-23

1993DIA Workshop, "Research Perspective in Structural Biology and Chemistry, 7th Biennial Meeting," Orlando, FL, January

Merck Pharmaceuticals, Rahway, NJ, March

The Biological Chemistry Seminar Series, University of Pennsylvania, April

Cold Spring Harbor Symposium, "Actin as the Generator of Tension During Muscle Contraction," New York, April

American Crystallographic Association, "The 2.6 Å Resolution Structure of the Profilin:actin Complex," Albuquerque Convention Center, May

The 22nd Meeting of the Federation of European Biochemical Societies, Stockholm, Sweden, July

The European Cytoskeletal Forum Meeting, Assisi, Italy, September

1992Biophysics Section of the New York Academy of Sciences, "A New Theory of Muscle Contraction," New York, NY, February

Synthetic Vaccines Symposium, "Implications of Crystal Structure Analysis of Pertussis

Toxin for Vaccine Development," San Francisco, CA, April

International Conference, NIH, "Muscle as a Machine: Energy Transduction in the

Contractile System," Bethesda, MD, April

Departments of Anatomy and Physiology, The University of Michigan, "Actin Power-

Stroke: A New Theory of Muscle Contraction," Ann Arbor, MI, May

Royal Swedish Academy Workshop on Cell Motility, Kristineberg Marine Biology Station, Sweden

MSRI Summer Institute Workshop on Mechanochemical Engines, University of California

at Berkeley, San Francisco, CA, July

Fourth International Conference on Biophysics and Synchrotron Radiation, Tsukuba,

Japan, August

1991Venezuela Institute of Science (IVIC), Caracas, Venezuela

Stockholm University, Science & History Series, Stockholm, Sweden

Stockholm University, Faculty Club Lecture, Stockholm, Sweden

Dept. of Electrical Engineering, Cornell University, Ithaca, NY

Institute for Defense Analysis, Princeton, NJ

Dept. of Chemical Engineering, Princeton University

Indiana Molecular Biology Symposium VI, "Proteins as Machines", Indiana University,

Bloomington, IN

1990Biophysics Lecture, Harvard University, Cambridge, MA

Squibb Institute Lecture, Princeton, NJ

Stockholm University Lecture Series on Structural Biology, Sweden

J & J Focused Giving Symposium, New Brunswick, NJAmerican Cyanamid/Princeton Univ. Joint Symposium, Princeton, NJ

Dept. of Cell Biology, Stanford University Medical School, Stanford, CA

N.I.H. Workshop on the Future of Research in Muscle Contractility, Washington, DC

Dept. of Biochemistry, Univ. of North Carolina, Chapel Hill, NC

Dept. of Biochemistry, Emory University Medical School, Atlanta, GA

Dept. of Anatomy, Robert Wood Johnson Medical School, New Brunswick, NJ

Class of 1930, 60th Reunion Address, Princeton University

Dept. of Chemistry, Princeton University

Dept. of Chemistry, Rutgers University, Newark, NJ

Medical School, University of California at San Francisco, San Francisco, CA

MRC Laboratory of Molecular Biology, Cambridge, England

1989Drug Information Society Symposium, San Francisco, CA

Einstein College of Medicine, New York, NY

Bioscience89 International Symposium, Malmo, Sweden

Dept. of Chemistry, Oslo University, Oslo, Norway

Dept. of Chemistry, University of Kansas, Manhatten, KS

McNeil Pharmaceuticals, Philadelphia, PA

Protein Society Annual Meeting, Seattle, WA

J & J Council of Research Directors, Princeton, NJ

Biophysics Dept., Downstate Medical College, Brooklyn, NY

PUBLICATIONS

Lassing, I., Hillberg, L., Hoglund, A.-S., Karlsson, R., Schutt, C., Lindberg, U. “Tropomyosin is a tetramer under physiological salt conditions”, Cytoskeleton 67:599-607 (2010)

Lindberg, U., Schutt, C.E., Goldman, R.D., Nyakern-Meazza, M., Hillberg, L., Rethge, LSZ, Grenklo, S. ‘Tropomyosin Regulates the Impact of Actin Binding Proteins on Actin Filaments” in TROPOMYOSIN, Advances in Experimental Medicine and Biology 644:223-231 (2008)

Grenklo, S., Hillberg, L., Rathge, L.S.Z, Pinaev, G., Schutt, C.E., Lindberg, U. “Tropomyosin Assembly Intermediates in the Control of Microfilament Ssytem Turnover”. Eur. Cell Biol. 87:905-920 (2008)

Ball, J.M., Parr, R.D., and Schutt, C.E. "Analysis of Rotavirus NSP4 Genetic Groups, Structure, and Function", Chapter18: Segmented Double-Stranded RNA Viruses: Structure and Molecular Biology, Patton, John F. , Editor, Horizon Scientific Press (2008)

Lovelace, J.J., Murphy, C.R., Daniels, L., Narayan, K., Schutt, C.E., Lindberg, U., Svensson, C., Borgstahl, G.E.O. "Protein Crystals can be Incommensurately Modulated", J. Appl. Cryst. 41:600-605 (2008)

Lindberg U., Karlsson, R., Lassing, I., Schutt, C.E., Hoglund, A-S, "The Microfilament System and Malignancy, Seminars in Cancer Biology, 18:2-11 (2008)

Lassing, I., Schmitzberger, F., Bjornstedt, M., Holmgren, A., Nordlund, P., Schutt, C., Lindberg, U. "Molecular and Structural Basis for Redox Regulation of -actin", J. Mol. Biol., 370:331-348 (2007).

Schuler, H., Karlson, R., Schutt, C.E., and Lindberg, U. “The Connection Between Actin ATPase and Polymerization”, Advances in Molecular and Cell Biology, 37:49-66 (2006).

Hillberg, L, Rathje, L-S.Z, Nyakern-Meazza, M., Helfand, B., Goldman, R.D., Schutt, C.E., Lindberg, U. “Tropomyosins are present in lamellipodia of motile cells”, Eur. J. Cell Biol. 85: 399-409 (2006)

Lovelace, J.J., Narayan, K., Chik, J.K., Bellamy, H.D., Snell, E.H., Lindberg, U., Schutt, C.E., Borgstahl, G.E.O. "Imaging modulated reflections from a semi-crystalline state of profilin : actin crystals." J. of Appl. Cryst. 37: 327-30 (2004).

M. Nyåkern-Meazza, K. Narayan, C. E. Schutt, and U. Lindberg, “Tropomyosin and gelsolin cooperate in controlling the microfilament System”, J. Biol. Chem. 277:28774-28779 (2003)

Narayan, K., S. Chumnarnsilpa, H. Choe, E. Irobi, D. Urosev, U. Lindberg, C. E. Schutt, L. D. Burtnick and R. C. Robinson. "Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin." FEBS Lett 552(2-3): 82-5 (2003).

Nyman, T., R. Page, C. E. Schutt, R. Karlsson and U. Lindberg. "A cross-linked profilin-actin heterodimer interferes with elongation at the fast-growing end of F-actin." J Biol Chem 277(18): 15828-33 (2002).

T. Nyman, H. Schüler, E. Korenbaum, C. E. Schutt, R. Karlsson and U. Lindberg, “The Role of MeH73 in Actin Polymerization and ATP hydrolysis”, J. Mol. Biol. 317:577-589 (2002).

T. Nyman, R. Page, C. E. Schutt, R. Karlsson and U. Lindberg, “A Cross-linked Profilin-Actin Heterodimer Interferes with Elongation at

the Fast-growing End of F-actin.”, Journal of Biological Chemistry, 277(18): 15828-15833, (2002).

S. L. Springs, S.E. Bass, G. Bowman, I. Nodelman, C. Schutt & G. L. McLendon, “A Multigeneration analysis of Cytochrome b562 redox variants: evolutionary strategies for modulating redox potential revealed using a library approach”, Biochemistry, 41(13):4321-4328 (2002).

R. Chakrabarti, & C.E. Schutt. "Novel Sulfoxides Facilitate GC-Rich Template Amplification"; Biotechniques 32(4) (2002)

R. Chakrabarti, & C.E. Schutt. “The enhancement of PCR amplification by low molecular-weight sulfones"; Gene 274:293-298 (2001).

R. Chakrabarti, & C.E. Schutt. "The enhancement of PCR amplification by low molecular-weight amides", Nucleic Acids Research, 29(11):2377-2381. (2001)

C. E. Schutt, & Lindberg, Uno. "The New Architectonics: an invitation to structural biology", The New Anatomist, 261(5): 198-216 (2000).

G.D. Bowman, I.M. Nodelman, Y. Hong, N.-H. Chua, U. Lindberg & C.E. Schutt, “A Comparative Structural Analysis of the ADF/Cofilin Family”. PROTEINS: Structure, Function, and Genetics , 41:374-384 (2000).

H. Schuler, CE Schutt, U. Lindberg & R. Karlsson. “Covalent binding of ATPgS to the nucleotide-binding site in S14C-actin. FEBS Letters”, 476(3):155-9 (2000).

H. Schuler, M. Nyakern, C.E. Schutt, U. Lindberg & R. Karlsson. “Mutational Analysis of Arginine-177 in the Nucleotide-binding site of -actin” (European Journal of Biochemistry, 267(13):4054-62 (2000).

G. D. Bowman, Nodelman IM, Levy O, Lin SL, Tian P, Zamb TJ, Udem SA, Venkataraghavan B, Schutt CE. "Crystal structure of the oligomerization domain of NSP4 from rotavirus reveals a core metal-binding site." J Mol Biol, 304(5):861-71 (2000).

U. Lindberg & C.E. Schutt. “Gelsolin”. Encyclopedia of Molecular Biology. (T. Creighton, Ed). John Wiley & Sons, Inc. p. 965 (1999).

U. Lindberg & C.E. Schutt. “Profilin”. Encyclopedia of Molecular Biology. (T. Creighton, Ed). John Wiley & Sons, Inc. pp. 1960-1962 (1999).

U. Lindberg & C.E. Schutt. “Actin-binding Proteins”. Encyclopedia of Molecular Biology. (T. Creighton, Ed). John Wiley & Sons, Inc. pp 32-48 (1999).

H. Schuler, H., U. Lindberg, C.E. Schutt & R. Karlsson. “Stabilities of actin isoforms. Thermal Unfolding of G-actin Monitored with the Dnase I-inhibition Assay”. European Journal of Biochemistry, 267(2): 476-86 (1999).

I.Nodelman, G. Bowman, U. Lindberg & C.E. Schutt. “X-ray Structure Determination of Human Profilin II: A Comparative Structural Analysis of Human Profilins”. Journal of Molecular Biology, 294, 1271-1285 (1999).

C. Kreatsoulas, U.Lindberg & C.E. Schutt, “Nouveau Regard sur le Muscle”. Les Cahiers de Science & Vie. 53: 78-87 (1999).

H. Schuler,, E. Korenbaum, C.E. Schutt, U. Lindberg. & R. Karlsson, “Mutational Analysis of Serine-14 and Aspartic Acid-157 in the Nucleotide Binding Site of -actin”. European Journal of Biochemistry, 265, 210-220 (1999).

E. Korenbaum, P. Nordberg, C. Björkegren-Sjögren, C. E. Schutt, U. Lindberg, R. Karlsson, "The Role of Profilin in Actin Polymerization and Nucleotide Exchange," Biochemistry, 37, 9274-9283 (1998).

E. Korenbaum, P. Nordberg, C. Björkegren-Sjögren, C. E. Schutt, U. Lindberg, R. Karlsson, "The Role of Profilin in Actin Polymerization and Nucleotide Exchange," Biochemistry, 37, 9274-9283 (1998).

R. Page, U. Lindberg and C. E. Schutt, Domain Motions in Actin,” Journal of

Molecular Biology, 280, 463-474 (1998)

C. Schutt And U. Lindberg, “Muscle Contraction as a Markov Process,” Acta Physiological Scandanavica,163, 307-324 (1998).

C. E. Schutt, C. Kreatsoulas, R. Page, and U. Lindberg, “In Reply”, Nature Structural Biology, 4, 684 (1997).

C. E. Schutt, C. Kreatsoulas, R. Page, and U. Lindberg, “Plugging into Actin’s Architectonic Socket,” Nature Structural Biology, 4, 169-172 (1997).

L. Tong, D. M. Ho, N. J. Vogelaar, C. E. Schutt and R. A. Pascal, Jr., “The Albatrossenes: Large, Cleft-Containing, Polyphenyl Polycyclic Aromatic Hydrocarbons.” J. Am. Chem. Soc., 119, 7291-7302 (1997).

K. S. Thorn, H. E. M. Christensen, R. Shigeta, Jr., D. Huddler, Jr., L. Shalaby, U. Lindberg, N.-H. Chua, C. E. Schutt, “The Crystal Structure of a Major Allergen from Plants,” Structure, 5, 19-32 (1997)

J. K. Chik, U. Lindberg, C. Schutt, “The Structure of an Open State of -actin at 2.65 Å Resolution,” Journal of Molecular Biology, 263, 607-623 (1996).

X. Qiao, M. A. Padula, D. M. Ho, N. J. Vogelaar, C. E. Schutt and R. A. Pascal, Jr., “Octaphenylnaphthalene and Decaphenylanthracene,” J. A. C. S., 118, 741-745 (1996).

C. E. Schutt, M. D. Rozycki, J. C. Myslik and U. Lindberg, “A Discourse on Modeling F-actin,” Journal of Structural Biology, 115, 186-198 (1995).

G. Pinaev, C. E. Schutt, U. Lindberg, “The Effect on Actin ATPase of Phalloidin and Tetramethylrhodamine Phalloidin,” FEBS Letters, 369, 144-148 (1995).

M. D. Rozycki, J. K. Chik, U. Lindberg and C. Schutt, “Crystallographically Observed Conformational Changes and Sulfhydryl Reactivity in Actin,” Biophysical J., 68, 367s (1995).

C. Schutt, M. Rozycki, J. Chik, U. Lindberg, "Structural Studies on the Ribbon-to-Helix Transition in Profilin:Actin Crystals," Biophysical J., 68, 12s-18s (1995).

R. Susnow, C. Schutt, H. Rabitz, "Principal component analysis of dipeptides," Journal of Computational Chemistry, 15, 963-980 (1994).

R. Susnow, C. E. Schutt, H. Rabitz, S. Subramanian, , "Conformational Study of Dipeptides - A Sensitivity Analysis Approach", Journal of Computational Chemistry, 15, 947-962 (1994).

E. S. Cedergren-Zeppezauer, N. C. W. Goonesekere, M. D. Rozycki, J. C. Myslik, Z. Dauter, U. Lindberg, C. E. Schutt, "Crystallization and Structure Determination of Bovine Profilin at 2.0 Å Resolution," J. Mol. Biol., 24, 459-475 (1994).

C. E. Schutt, M. D. Rozycki, U. Lindberg, "What's the Matter with the Ribbon?" Current Biology, 4, 185-186 (1994).

R. Shigeta Jr., K. Forest, L. Yan, D. Kahne, and C. Schutt, "The Isomorphous Binding of Mercury-Substituted Thio-Saccharides to Pertussis Toxin Crystals Yields Crystallographic Phases," Acta Crystallographica, D50, 71-74 (1994).

M. Rozycki, J. Myslik, C. Schutt, and U. Lindberg, "Structural Aspects of Actin Binding Proteins," Current Opinion in Cell Biology, 6, 87-95 (1994).

C. Björkegren, M. Rozycki, C. E. Schutt, U. Lindberg, and R. Karlsson, "Mutagenesis of Human Profilin Locates Its Poly (L-Proline)-Binding Site" FEBS Letters, 33, 123-126.(1993).

C. E. Schutt, J. C. Myslik, M. D. Rozycki, N. Goonesekere and U. Lindberg, "The Structure of Crystalline Profilin:ß-Actin", Nature, 365, 810-816 (1993).

P. Aspenström, C. Schutt, U. Lindberg, R. Karlsson, "Mutations in b-actin: Influence on Polymer Formation and on Interactions with Myosin and Profilin", FEBS Letters, 329, 163-170 (1993).

C. Schutt and U. Lindberg, "A New Perspective on Muscle Contraction", FEBS Letters, 325, 59-62 (1993).

K. Forest, R. Shigeta, C. Schutt, D. Winkelmann, and J. Gotto, "Electron Crystallography of Pertussis Toxin," Witholt et al., (Eds.), in Bacterial Protein Toxins, Zbl. Bakt. Suppl. 23, Gustav Fischer, Stuttgart, Jena, New York, 304-305 (1992).

M. Raghavan, U. Lindberg and C. E. Schutt, "The Use of Alternative Substrates in the Characterization of Actin and Carnosine Methylating Enzymes," European Journal of Biochemistry, 210, 311-318 (1992).

C. E. Schutt and U. Lindberg, "Fishing deep beneath the shallow water," Current Biology, 2, 563-564 (1992).

K. Forest and C. E. Schutt, "Protein Engineering for Structure Determination," Current Opinion in Structural Biology, 2, 576-581 (1992).

J. Krueger, J. Stock and C. E. Schutt, "Evidence that the Methylesterase of Bacterial Chemotaxis may be a Serine Hydrolase", Biochim. Biophys. Acta., 1119, 322-326 (1992).

V. Raghunathan, P. C. Mowery, M. D. Rozycki, U. Lindberg and C. E. Schutt, "Structural Changes in Profilin Accompany its Binding to Phosphatidylinositol 4,5-Bisphosphate", FEBS Letters, 297, 46-50 (1992).

R. Susnow, R. B. Nachbar, C. E. Schutt and H. Rabitz, "The Study of Amide Structure Through Sensitivity Analysis", J. Phys. Chem., 95, 10662-10676 (1992).

C. E. Schutt and U. Lindberg, "Actin as the Generator of Tension during Muscle Contraction", P.N.A.S, 89, 319-323 (1992) .

R. Susnow, R. B. Nachbar Jr., C. E. Schutt and H. Rabitz, "The Sensitivity of Molecular Structure to Intramolecular Potentials", J. Phys. Chem, 95, 8585-8597 (1991).

C. E. Schutt, U. Lindberg, and J. Myslik, "Actin in Ribbons," Nature, 508 (1991) (Scientific correspondence).

C. E. Schutt and U. Lindberg, "Scratching the Back of the Cortex," Current Biology, 4, 257-258 (1991).

N. J. Vogelaar, U. Lindberg, and C. E. Schutt, "Crystallization and Preliminary X-ray Analysis of Gc, the Vitamin D-Binding Protein in Serum" J. Mol. Biol., 220, 545-547 (1991).

D. M. Bollag, P. Seddon, P. Bohlen, Y. Gluzman and C. E. Schutt, "Preliminary X-ray Crystallographic Analysis of a Modified Basic Fibroblast Growth Factor" J. Mol. Biol., 218, 493-494 (1991).

M. Rozycki, C. E. Schutt and U. Lindberg, "Affinity Chromatography-based Purification of Profilin-Actin", Methods in Enzymology, 196, 100-118 (1991).

M. Raghavan, J. W. Gotto, J. V. Scott and C. E. Schutt, "Preliminary X-ray Crystallographic Analysis of Holotoxin from Bordetella Pertussis", J. Mol. Biol., 213, 411-414 (1990).

J. K. Krueger, A. M. Stock, C. E. Schutt, C. E., J. B. Stock "Inclusion Bodies from Proteins Produced at High Levels in E. Coli" in Protein Folding, (ed. L. M. Gierasch and J. King) Amer. Assoc. for the Adv. Science, (1990) pp. 136-143.

C. E. Schutt, M. U. Lindberg, J. Myslik, and N. Strauss, "Molecular Packing inProfilin:Actin Crystals and its Implications", J. Mol. Biol., 209, 735-746 (1989).

M. Raghavan, C. K. Smith, C. E. Schutt, "Analytical Determination of Methylated Residues in Actin", Anal. Biochem., 178, 194-197 (1989).

J. K. Krueger, M. H. Kulke, C. E. Schutt, and J. B. Stock, "Protein Inclusion Body Formation and Purification", Biopharm. Manufacturing, 2, 40-45 (1989).

A. M. Stock, J. M. Mottonen, J. B. Stock and C. E. Schutt, "Three-dimensional Structure of CheY, the response regulator of bacterial chemotaxis", Nature, 337, 745-749 (1989).

J. J. Wendoloski, S. Kimatian, C. E. Schutt and F. R. Salemme, "Molecular Dynamics Simulation of a Phospholipid Micelle", Science, 243, 636-638 (1989).

C. E. Schutt and U. Lindberg, "The Nature of the Actin Molecule", Molecular Mechanisms in Muscular Contraction, (J. Squire, ed.) MacMillan Press, London (1989) pp. 49-63.

C. E. Schutt, "Protein Structure: What's left out tells the story", Nature, 334, 381-382 (1988).

A. M. Stock, D. C. Wylie, J. M. Mottonen, A. N. Lupas, E. G. Ninfa, A. J. Ninfa, C. E. Schutt and J. B. Stock, "Phospho-Proteins Involved in Bacterial Signal Transduction", Cold Spring Harbor Symposium on Quantitative Biology on "Sensory Signal Transduction" 53, 49-57 (1988).

U. Lindberg, C. E. Schutt, E. Hellsten, A. C. Tjader and T. Hult. "The Use of Poly L-Proline-Sepharose in the Isolation of Profilin and Profilactin Complexes", Biophys. Biochim. Acta, 967, 391-400 (1988).

C. E. Schutt, "Muscle Regulation: Movement on the Aufbaubahn", Nature, 325, 757-758 (1987).

Clarence E. Schutt, "The Calchemists", Nature, 325 (1987). (Comment)

C. Schutt, N. Strauss, K. Morikawa, Uno Lindberg, "Crystallographic Studies on the Profilin:actin Complex" in "The 11th Taniguchi International Symposium: Actin, Its Structure and Functions". Edited by T. Yanagida, University of Tokyo Press, 10-17 (1986).

C. Schutt and P. Evans, "Relative Absorption Corrections for Rotation Films, Acta Cryst., A41, 568-570 (1985).

C. Schutt, "Hands on the Calcium Switch", Nature, 315, 15 (1985).

C. Schutt, N. Strauss, U. Lindberg, "Crystallographic Studies of the Profilin:actin Complex", J. Mus. Res. Cell. Mot., Vol. 6 (5) 668, (1985).

S. C. Harrison, C. E. Schutt, F. Winkler and R. Durbin, "Data Collection fromVery Large Crystalline Structures", Methods in Enzymology Vol. 114, 211 (1985).

J. D. Harvey, A. R. Bellamy, W. C. Earnshaw and C. Schutt, "Biophysical Studies of Reovirus Type 3, IV. Low -Angle X-ray Diffraction Studies" Virology, 112, 240-249 (1981).

J. P. Langmore and C. E. Schutt, "Low-Angle X-ray Scattering from Chromatin", Nature, 291, 359 (1981).

J. P. Langmore and C. E. Schutt, "The Higher Order Structure of Chicken Erythrocyte Nuclei in vivo", Nature, 288, 620-622 (1980).

F. K. Winkler, C. E. Schutt and S. C. Harrison, "The Oscillation Method for Very Large Unit Cells", Acta Cryst., A35, 901-911 (1979).

S. C. Harrison, A. J. Olson, C. E. Schutt and F. K. Winkler, "Tomato Bushy Stunt Virus at 2.9 Å Resolution", Nature, 276, 368-373 (1978).

F. K. Winkler, C. E. Schutt, S. C. Harrison and G. Bricogne, "Tomato Bushy Stunt Virus at 5.5 Å Resolution", Nature, 265, 509-513 (1977).

C. Schutt and F. K. Winkler, "The Oscillation Method for Very Large Unit Cells" in The Rotation Method in Crystallography, Eds., Arndt & Wonacott, (North-Holland, 1977), pp. 173-185.

J. S. Mattson and C. E. Schutt, "Application of Digital Minicomputers to Colour Matching" in Laboratory Systems and Spectroscopy, Eds., Mattson and Mark, Vol. 5, (Marcel Dekker, Inc., 1977), pp. 141-155.

J. S. Mattson, Harry B. Mark, Jr., A. Prostak and C. E. Schutt, "Potential Application of an Infra-red Spectroradiometer for Remote Detection and Identification of Oil Slicks on Water", Env. Sci. & Tech., 5, 415-419 (1971).

J. S. Mattson, Harry B. Mark, Jr., R. L. Kolpack and C. E. Schutt, "A Rapid, Nondestructive Technique for Infra-red Identification of Crude Oils by Internal Reflexion Spectrometry", Anal. Chem., 42 234-237 (1970).

PATENTS

"Compositions and Methods for Enhancing Polynucleotide Amplification Reactions", Raj Chakrabarti & Clarence E. Schutt - Pat. No. 7,276,357 - issued October 2, 2007

“Crystal Structure of rotavirus NSP4 Peptide”, by Gregory D. Bowman, Orlie Levy, Ilana Nodelman, Clarence Schutt and Timothy J. Zamb. (Pending, Application No. 60/250,810)

“Compositions and methods for enhancing polynucleotide amplification reactions”, Chakrabarti, Raj & Schutt, Clarence E. - Pat. No. 6,949,368 – issued Sept. 2005 – Assignee: The Trustees of Princeton University.