cheminform abstract: green synthesis of 5-substituted-1,3,4-thiadiazole-2-thiols as new potent...
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Thiadiazole derivativesR 0300 DOI: 10.1002/chin.201050135
Green Synthesis of 5-Substituted-1,3,4-thiadiazole-2-thiols as New Potent Nitrifi-cation Inhibitors. — A new one-pot method is used for the synthesis of acid hydra-zides which are further processed in a similar manner to that used in the conventional protocol. This innovation improves the overall synthetic protocol for the thiadiazolethi-ols (III) in terms of yield, time, energy, atom economy and other green chemistry char-acteristics. All compounds with exception of (IIIa) and (IIIc) reveal promising nitrifi-cation inhibition and may be prototypes for the discovery of potent analogues through compound library design and screening. — (SAHA, A.; KUMAR*, R.; KUMAR, R.; DEVAKUMAR, C.; J. Heterocycl. Chem. 47 (2010) 4, 838-845, DOI:10.1002/jhet.345 ; Div. Agric. Chem., Indian Agric. Res. Inst., New Delhi 110 012, India; Eng.) — H. Hoennerscheid
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ChemInform 2010, 41, issue 50 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim