1999 pyridine derivatives

pyridine derivativesR 0380

12 - 157Direct Synthesis of Unsymmetrical Bis-heterocycles from 2-Heterosubstituted 6-Lithiopyridines. — The unusual and regioselectivemetalation of pyridines (I) at their C-6 position is achieved using a BuLi/Me2N–(CH2)2–OLi complex. This method allows the synthesis of symmetrical andunsymmetrical bis-heterocycles (III). — (GROS, PHILIPPE; FORT, YVES;J. Chem. Soc., Perkin Trans. 1 [old] (1998) 21, 3515-3516; Synth. Org. React.,Fac. Sci., CNRS, Univ. Henri Poincare, F-54506 Vandoeuvre-les-Nancy, Fr.; EN)

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