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o--.ss in State Hospitals Editor: In the arricle in the issue on changing characteris- tics of schizophrenic patients admit- ted hospitals, the conclusio draw . by Thompson and associate!> (1) . weakened considerably by/ a oversight· involving fundin of care in state psychiairic hospit . By , Medicaid will not reim- burse fr tanding psychiatric llospi- cals for c provided to patieiiltS be- ges of 21 and 64 There- percentages of te hos- pital care ded by Medicaid are not a result of a deterioratin economic situation for patients bu rather re- flect: current onstraints n reimbur- sement. I !ad , same patient pop- ulation been treated ip general-hos- pital-based unitS that do receive Medicaid reithbursement for the 18-to-21 age group, the percent- age of patients cpvered by Medicaid might be up to times higher. My conclusion is that rather than pour additional ding into anti- quated instiruti , os, we shoufd pro- mote downsizia'g of state facilities t1 . through the aggressive development of sma11er communiry-based psychi- atric units in local hospitals. Such units cat! provide better-qualicy care,help keep the p!Uient closer to home, and 1Pand the use of partial hospitalization. They can improve the financial 'situation at the state level by reducing the cost of operat- ing state nospitals while increasing the amount of federal Medicaid matching funds flowing into the state and to the general hdspitaIs (2). ROBERT A. PREHN, PH.D. Dr. p ,Jn is administrator of the Oaks, the psychiatric hospital of the New Han- '\ rwer Regional Medical Center in Wil- mingtr)7l, North Carolina. References L ThompsonJW, BelcherJR, BR, et al: Changing characteristics of sth izo- phrenic patients admitted to state hospi- tals. Hospital and Communiry Psychiatry 44:231-235, 1993 2. Mottison WF, Prehn RA: A Win-Win Proposition: Rural Hospitals and Psychi- atric Services. Raleigh, NC, Notth Caro- lina Hospital Association, Jan 1993 Hospital and Communicy Psychiatry JAMES W. THOMPSON, are risk factOrs for developing manic or hypomanic symptOms. Our observations indicate a defi- nite temporal relationship between obsessive-compulsive and manic symptoms; the development of hy- pomanic or manic symptoms follows the progressive reduction of obses- sive-compulsive symptoms. More- over, the assessment of obsessive- compulsive patients for personality disorders revealed the presence of borderline personality disorder in 3.3 percent of such patients (3). When . these patients were treated with pro- serotonergic antiobsessional drugs, they experienced reduced impulse control, dysphoria, and increased ag- gressiveness and reckless acts, symp- toms similar to those found in mania. In obsessive-compulsive patients with borderline personality disorder, psychomotOr activation appears in the first weeks of treatment, before obsessive symptoms are reduced, and the clinicai picrure is characterized by expansive mood with claiming ideation, recurrent episodes of re- duced impulse control, and loss of insight. Obsessions and compulsions remain unchanged, with a worsening of global functioning. We agree with Stein and asso- ciates' suggestion (4) that the syn- dromes described are the phenome- ,. I I i ! , M.D., M. P.H. JOHN R. BELCHER, PH.D. BRUCE R. DEFORGE, M.A. C. PATRICK MYERS, M.A. MARrr.YN J. ROSENSTEIN, M.A. rug-Induced Mania To the Editor: We were greatly in- terested in a report recently pub- lished elsewhere about drug-induced mania in obsessive-compulsive pa- tients (1). During the last year we observed drug-induced mania in some patients treated with clomipra- mine, fluoxetine, and fluvoxamine in our Obsessive-Compulsive Disorder Center in Milan. Comorbidity appears to be impor- tant in the development of chis com- plication. The frequent co-occur- rence of affective syndromes, ofa pos- itive family histoty for mood disor- der, or both (2) suggests chat these July 1993 VoL 44 No.7 : nological expression ofa serotonerg ic dysfunction, even though data about biological and clinical correlates of serotonergic fimction deficit seem to be Although reduced impulse control and aggressiveness .have been explained as consequences \ \ of a serotOnergic deficit, treatment y with proserotOnergic agents seems, in our clinical observation, to worsen these symptOms, at least in patients with obsessive-compulsive disorder. Considering the clinical charac- teristics of the antidepressant-in- duced symptoms observed, we creat such symptoms with catbamazepine (5) or lithium. For patients who seem to be at risk of developing hypomanic or manic symptOms because of previ- ous affective episodes or family his- tOry and personaiity profile, pharma- cological management involves a slower increase of the dosage of pro- serotonergic antidepressants, combi- nation of such drugs with stabilizing 689 ; I

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o--.ss~ eivlv~'~!) ~

~e;dicaid in State Hospitals

T~the Editor: In the arricle in the ~ch issue on changing characteris­tics of schizophrenic patients admit­ted ~state hospitals, the conclusio draw . by Thompson and associate!> (1) . weakened considerably by/a Signifi~t oversight· involving ~he fundin of care in state psychiairic hospit .

By , Medicaid will not reim­burse fr tanding psychiatric llospi­cals for c provided to patieiiltS be­

ges of 21 and 64 There­percentages of te hos­

pital care ded by Medicaid are not a result of a deterioratin economic situation for patients bu rather re­flect: current onstraints n reimbur­sement. I !ad , same patient pop­ulation been treated ip general-hos­pital-based ps~hiatr¥ unitS that do receive Medicaid reithbursement for the 18-to-21 age group, the percent­age of patients cpvered by Medicaid might be up to f~u.r times higher.

My conclusion is that rather than pour additional ding into anti­quated instiruti , os, we shoufd pro­mote downsizia'g of state facilities t1 . through the aggressive development of sma11er communiry-based psychi­atric units in local g~nera1 hospitals. Such units cat!provide better-qualicy care,help keep the p!Uient closer to home, and 1Pand the use of partial hospitalization. They can improve the financial 'situation at the state level by reducing the cost ofoperat­ing state nospitals while increasing the amount of federal Medicaid matching funds flowing into the state and to the general hdspitaIs (2). ~

ROBERT A. PREHN, PH.D.

Dr. p,Jn is administrator of the Oaks, the psychiatric hospital ofthe New Han­ '\ rwer Regional Medical Center in Wil­mingtr)7l, North Carolina.

References

L ThompsonJW, BelcherJR, DeFor~e BR, et al: Changing characteristics of sth izo­phrenic patients admitted to state hospi­tals. Hospital and Communiry Psychiatry 44:231-235 , 1993

2. Mottison WF, Prehn RA: A Win-Win Proposition: Rural Hospitals and Psychi­atric Services. Raleigh, NC, Notth Caro­lina Hospital Association, Jan 1993

Hospital and Communicy Psychiatry

JAMES W. THOMPSON,

are risk factOrs for developing manic or hypomanic symptOms.

Our observations indicate a defi­nite temporal relationship between obsessive-compulsive and manic symptoms; the development of hy­pomanic or manic symptoms follows the progressive reduction of obses­sive-compulsive symptoms. More­over, the assessment of obsessive­compulsive patients for personality disorders revealed the presence of borderline personality disorder in 3.3 percent of such patients (3). When

. these patients were treated with pro­serotonergic antiobsessional drugs, they experienced reduced impulse control, dysphoria, and increased ag­gressiveness and reckless acts, symp­toms similar to those found in mania.

In obsessive-compulsive patients with borderline personality disorder, psychomotOr activation appears in the first weeks of treatment, before obsessive symptoms are reduced, and the clinicai picrure is characterized by expansive mood with claiming ideation, recurrent episodes of re­duced impulse control, and loss of insight. Obsessions and compulsions remain unchanged, with a worsening ofglobal functioning.

We agree with Stein and asso­ciates' suggestion (4) that the syn­dromes described are the phenome­

,. I

I i !

, ;

I,

M.D., M.P.H. JOHN R. BELCHER, PH.D.

BRUCE R. DEFORGE, M.A. C. PATRICK MYERS, M.A.

MARrr.YN J. ROSENSTEIN, M.A.

~ rug-Induced Mania

To the Editor: We were greatly in­terested in a report recently pub­lished elsewhere about drug-induced mania in obsessive-compulsive pa­tients (1). During the last year we observed drug-induced mania in some patients treated with clomipra­mine, fluoxetine, and fluvoxamine in our Obsessive-Compulsive Disorder Center in Milan.

Comorbidity appears to be impor­tant in the development of chis com­plication. The frequent co-occur­rence ofaffective syndromes, ofa pos­itive family histoty for mood disor­der, or both (2) suggests chat these

July 1993 VoL 44 No.7

:nological expression ofa serotonerg ic dysfunction, even though data about biological and clinical correlates of serotonergic fimction deficit seem to be contradi~ory. Although reduced impulse control and aggressiveness

. have been explained as consequences \ \of a serotOnergic deficit, treatment y

with proserotOnergic agents seems, in our clinical observation, to worsen these symptOms, at least in patients with obsessive-compulsive disorder.

Considering the clinical charac­teristics of the antidepressant-in­duced symptoms observed, we creat such symptoms with catbamazepine (5) or lithium. For patients who seem to be at risk of developing hypomanic or manic symptOms because ofprevi­ous affective episodes or family his­tOry and personaiity profile, pharma­cological management involves a slower increase of the dosage of pro­serotonergic antidepressants, combi­nation ofsuch drugs with stabilizing

rflJ'I\~ 689 ; i

i ~

I

4

agents from the beginning of treat­ment, or use of both approaches.

Systematic investigations are needed to confinn that the presence bf borderline personality disorder in obsessive-compulsive patients pre..,. disposes such patients to antidepres­sant-induced side effects and to iden­tify other fuctors.

EMANUEI.A. MUNDO, M.D. PAOLO RONCHI, M.D. LAURA BEllODI, M.D.

The authars are associated with the de­partment ofneuropsychiatry at the H. S. Raffaele Institute in Milan, Italy.

References

1. Viera E, Bernardo M: Anridep=sanr-in­duced mania in obsessivc:-<ompulsive dis­order (lrr). AmericanJoumal ofPsychiarry l49:l282,l992 "

2. Bellodi 1, Sciuto G, Oi~ria G, er al: Psychiatric disorders in rhe fiunjlies of pariencs with obsessive-compulsive disor­der, Psychiarry Research 42:111-l20, 1992

3. Sciuco G, Diaferia G, Battaglia M, er al: OSM-ill-R personaliry disorders in panic and obsessive-compulsive disorder: acom­parison srudy. Comprehensive Psychiarry 32:450-457, 1991

4. Srein DJ, Hollander E, De Caria C. er al: oeD: a disorder with anxiecy, aggression, impulsivicy, and depressed mood. Psychi­arty Research 36:237-239, 1991

5. Keck PE, McElroy SL, Friedman LM: Valproare and carbamazepine in the rrear­ment of panic and poscrrawnatic stress disorder, withdrawal scates, and behav­ioral dysconcrol syndromes. Journal of Clinical Psychopharmacology l2:36S­41S, 1992

Drug Use by D y Patients

To the Editor: Th repo~ by Cohen and Henkin (1) in he February issue on the prevalence f substance abuse by seriously ment y ill patients in a partial hospital p gram encouraged me to look at my wn day treatmenc program at the W ter P. CarrerCen­ter, a small state hospital in inner­city Baltimore. T e hospital serves a socially disadva taged catchment area that appears be similar to the one described b the authors in inner-city Philad phia.

Oue ofa COtal 0 42 active patiencs in the day creat nt program, I re­viewed the char ,S of 28 patiencs whom I had persofually examined, or 66 percenc. Fourteen of the 28 pa­

690 •

Jtients were men an 14 were women. They ranged in a~ from 24 co 63 years, with mean ~_eof 39.4. Fifty­four percent were ~can American, 54 percent had c pleted the 12th grade, and 54 perc nt had been jailed at least once. All ere unemployed. All had been hosp . ed for psychi­atric disorders, m St within the last sixmonchs.

Twenty-four 0 the 28 patients, or 86 percent, had ptychotic diagnoses based on DSM- I-R criteria. Of these patients, te had a diagnosis of schizophrenia, ei ht of schizoaffec­tive disorder, four fbipolar disorder, and one each of m jor depressive dis­order with psyc otic features and psychotic disor er not otherwise specified.

Four patients had nonpsychotic diagnoses; three ,ad dysthymic dis­order and one had multiple personal­icy disorder with eccive symptoms. Although none 0 me patients had a diagnosis of pe sonality disorder alone. 13 had a ersonality disorder accompanied by anomer disorder, and in five patien personalicy disor­der was vety prominent.

Sixteen of the 8 patients, or 57 percenc, were also substance abusers. Alcohol, by far Me most common substance of abus ,was the preferred or only drug of 1 of the 16 patients. Six of the 16 patients used a variety of subscances, induding alcohol, marijuana, opiat , cocajne, and in­

' halants. Cohen and He 'n (1) found that

age and diagnosis were significant in differenciating s stance users from nonusers. In this ample, which was older than theirs and had a higher proportion ofwo en, gender ,and di­agnosis predicte substance abuse. Thirteen of the men were sub­stance abusers, compared with three of the 14 wome . Half of the 24 patients with psychotic diagnoses were substance abusers, as were six of the eight patients with mood disor­

, der (bipolar, major depressive, or dysthymic disorders),

Ten of the 13 patients with any personality disorder, four of the five patients with very prominent per­sonalicy disorder. and all four of the patients with non psychotic disorders were substance abusers. Therefore.

July 1993 Vol. -44 No.7

although substance Ibuse was pr.om­inent across diag bses, these data corroborate Cohe and Henkin's findings that subsqwce abusers tend to have diagnoses'~f either personal­ity disorder or affettive disorder.

These dara also confirm Cohen•and Henkin's find:ings that "a signif­ican~ numb:r of Wtients who arcend partIal hOSPlcals I Urban areas could also be abusing st et drugs and alco­hol." We have 'ed to meet this challenge by in egrating the hos­pital's addictions services program inco our day treamenc program.

Our program is flexible enough that drug abusels can parricipate in substance abuse groups and in indi­vidual addictio , s counseling; They can also accen Alcoholics Anony­mous and Narcotics Anonymous meetings in the building and me community. Breath analysis testsand urine drug screens are done routinely on some patienfs. D isulflram is used selectively. Cohtacts with outside sources of inforrbation, such as family members or Ot er care providers, are pursued. The patient governmenc places sanctio~ on patients who at­tend the prograb when intoxicated. Problems certainly remain, such as the occasional ~d for acute deroxi­fication and residencial rehabilitation beds. It is diffi t bue dearly impor­tant to consid both the individual needs of certai patients and the needs of a prog , that serves a di-

Dr. Starch i,r as,ristantprofessor ofpsychi­atry at the Un ·ver.rity of Maryland School ofMedici in Baltimore.

Reference

L Cohen E. H in I: Prevalence of sub­stance abuse b seriously mentally ill pa­ciencs in a parcial hospiral program. Hos­pi cal and ComqlUniry Psychiarry 44:l78­180, 1993

Hospitalphilia

To the Editor: Geller's approach (1) [0 the treatment of revolving-door patients with "hospitalphilia," de­scribed in the February issue. has much co offer. If we believe that pa­tients can help themselves improve, why do we reject the notion that they

Hospiral and Community Psychiarry