cerab : a haemodynamically proven technique for treating ... · a haemodynamically proven technique...
TRANSCRIPT
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CERAB : a haemodynamically proven
technique for treating extensive aortoiliac occlusive
disease
P. Goverde MD,
K. Lauwers MD, K.Taeymans MD, P. Verbruggen MD
Vascular Clinic ZNA, Antwerp, Belgium
M. Reijnen MD Phd, F. Grimme MD, J. Van Oostayen MD
Rijnstate Hospital, Arhnem, The Netherlands
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Diclosure
Speaker’s name: Peter Goverde I have the following potential conflicts of interest to report:
Consulting:
Abbott Vascular; Angioslide; Atrium Maquet Getinge
group; Bard Peripheral Vascular; Cardionovum; Cordis Cardinal Health; IMDS; Ivascular; Stille;
Veyran; Ziehm Imaging
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How to prevent ?
How
to treat ?
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• Results of kissing stents inferior compared to isolated stents in iliac artery or aorta • Patency affected by:
• Radial mismatch; aortic lumen dead space around the protruding segment of the stents • Differences in stent conformation • The overlap of the free proximal stent ends
•Re-circulation, turbulence and stasis •Mesenchymal tissue, thrombus and intimal hyperplasia
Greiner A, et al. J Endovasc Ther 2005; 12: 696-703 Sharafuddin MJ, et al. Ann Vasc Surg 2008;22:346-57. Hughes M, et al . Cardiovasc Intervent Radiol 2006; 29: 255-259
Lesions of the aortic bifurcation & kissing stents
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Lesions of the aortic bifurcation & kissing stents
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Covered
Endovascular
Reconstruction
Aortic
Bifurcation
A new technique to reconstruct
the aortic bifurcation with
3 Maquet Getinge V12 covered stents
for extensive occlusive disease
“Cerab-technique : a new approach in treating extensive aortoiliac occlusive disease”: Goverde P. Grimme F, Reijnen M., et al ; J Cardiovasc Surg 2013;54:383-7
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Advantages of covered stents
• May reduce the impact of radial mismatch
• May reduce the risk on embolization
• Prevention of in-stent re-stenosis
• May reduce the risk on rupture / perforation
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due to its specific characteristics:
• low profile
• double ePTFE layer
• easy and accurate deployment
• radial force
• Dog-bone type inflation of balloon
• diameter adaptiveness
(postdilation to a larger diameter is possible without damaging the stent structure and ePTFE )
Why using Bx covered stents ?
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Adaptiveness
1 stent V12 LD (12x 61 mm) = 4 different shapes
12mm
20mm
12mm
18mm
16mm
12mm
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– In vitro testing :
in collaboration with
• University of Twente, Enschede, The Netherlands; E. Groot Jebbink , P. Goverde, M. Reijnen
– In vivo
• Vascular Clinic ZNA, Antwerp,Belgium
• Rijnstate Hospital, Arhnem, The Netherlands
RESULTS
“The Science behind
the Technology”
Geometrical consequences of kissing stents and the Covered Endovascular Reconstruction of the Aortic Bifurcation configuration in an in vitro model for endovascular reconstruction of aortic bifurcation. Groot Jebbink E, Grimme FA, Goverde PC, van Oostayen JA, Slump CH, Reijnen MM .J Vasc Surg. 2015 May;61(5):1306-11.
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Results : in vitro
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Groot Jebbink et al. .J Vasc Surg. 2015 May;61(5):1306-11.
.
Results : in vitro
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Results : in vitro
• CERAB configuration : – Related to the best geometrical
conditions – Low radial mismatch – High stent conformation – Lower mismatch area – Lowest total mismatch volume or dead
space
– Compared to the other 3 configurations
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Particle Image Velocimetry measurements: Turbulence and recirculation at phases B and C
Lesions of the aortic bifurcation & kissing stents
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Particle Image Velocimetry measurements: Mostly laminar flow throughout the cardiac cycle
Dye injection
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RESULTS In VIVO
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February 2009 – March 2014 103 elective patients Acute cases (n=5) and chimney’s (n=5) excluded 61 (36-85) years Rutherford classification:
1 (n=1) 1% 2 (n=0) 0% 3 (n=64) 62% 4 (n=20) 19% 5 (n=17) 17% 6 (n=1) 1%
• Technical success 95%
Results CERAB : Antwerp and Arnhem
First Results of the Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) Technique for Aortoiliac Occlusive Disease. Grimme FA, Goverde PC, Verbruggen PJ, Zeebregts CJ, Reijnen MM. Eur J Vasc Endovasc Surg. 2015 Sep 3. [Epub ahead of print]
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ABI 0.64 ± 0.21 TASC -2
B n=5 (6%) C n=9 (9%) D n=88 (86%)
Risk factors: Smoking n=89 (87% )
Hypertension n=78 (76%)
Diabetes n=29 (29% )
Dyslipidemia n=91 (88%)
Coronary artery disease n=43 (42%)
Pulmonary disease n=46 (45%)
Renal disease n=18 (18%)
Results CERAB : Antwerp and Arnhem
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30-day mortality 0%
30-day complication rate 23% Hematoma groin (n=16)
Re-bleed (n=1)
Pseudoaneurysm (n=2)
Fever eci (n=2)
Atrial fibrillation (n=1)
30-day major complication rate 2% Renal failure (n=1)
Pneumonia (n=1)
ABI : 0.58 ±0.23 -> 0.91 ± 0.14
Hospital Admission 2 days (range 1-16 days)
Results CERAB : Antwerp and Arnhem
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6 m 12 m 18 m 24 m
Primary patency 91.5 87.3 87.3 82.3
Secondary patency 97.8 95.0 95.0 85.0
Freedom from TLR 93.7 88.2 88.2 85.6
Median follow-up 19 months
Limb salvage 100%
Results CERAB : Antwerp and Arnhem
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Conclusions
Covered endovascular reconstruction of the aortic bifurcation (CERAB) is safe and feasible and seems to be a valid alternative for surgery and/or kissing stents
Exploration of the chimney-CERAB, patient selection and the economic benefit may further expand the indications of this technique
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CERAB & Complex iuxtarenal Aortic Occlusive Disease
P. Goverde MD, Antwerp Belgium/ A. Schmidt MD, Leipzig Germany
2 chimney, V12 Atrium Maquet
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CERAB : a haemodynamically proven
technique for treating extensive aortoiliac occlusive
disease
P. Goverde MD,
K. Lauwers MD, K.Taeymans MD, P. Verbruggen MD
Vascular Clinic ZNA, Antwerp, Belgium
M. Reijnen MD Phd, F. Grimme MD, J. Van Oostayen MD
Rijnstate Hospital, Arhnem, The Netherlands