cell cycle (cell division), cell-cell interaction, growth and their control aging
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Core Course # MM 704 (Cellular and Molecular Pathology). Cell cycle (Cell division), Cell-cell interaction, growth and their control Aging Apoptosis Tissue injury and repair mechanisms Cell regenerating potential (Role of Stem Cells) Mediators, modulators and messengers - PowerPoint PPT PresentationTRANSCRIPT
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Cell cycle (Cell division), Cell-cell interaction, growth and their control
Aging Apoptosis Tissue injury and repair mechanisms Cell regenerating potential (Role of Stem Cells) Mediators, modulators and messengers
Antioxidants in health and disease
Core Course # MM 704
(Cellular and Molecular Pathology)
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Induced differentiation of stem cells by Induced differentiation of stem cells by small moleculessmall molecules
Strategies to enhance regenerative Strategies to enhance regenerative potential of stem cellspotential of stem cells
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Induced differentiation of stem cells by Induced differentiation of stem cells by small moleculessmall molecules
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Direct Differentiation of ES CellsDirect Differentiation of ES Cells
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Direct Differentiation of MSCsDirect Differentiation of MSCs
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DexamethasoneAscorbic acid5-azacytidineZebularine Retinoic acidNitric oxideDifluoromethylornithine (DFMO)
Small Molecules and Cardiac DifferentiationSmall Molecules and Cardiac Differentiation
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Zebularine
Differentiation of the Adult Stem Cells into Cardiac Differentiation of the Adult Stem Cells into Cardiac like cells by Small Moleculeslike cells by Small Molecules
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Differentiation of the Adult Stem Cells into Cardiac Differentiation of the Adult Stem Cells into Cardiac like cells by Small Moleculeslike cells by Small Molecules
Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x
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Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x
Differentiation of the Adult Stem Cells into Cardiac Differentiation of the Adult Stem Cells into Cardiac like cells by Small Moleculeslike cells by Small Molecules
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Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x
Differentiation of the Adult Stem Cells into Cardiac like cells Differentiation of the Adult Stem Cells into Cardiac like cells by Small Moleculesby Small Molecules
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Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.1755-5922.2012.00320.x
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Strategies to enhance regenerative potential Strategies to enhance regenerative potential of stem cellsof stem cells
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(a) Hypoxic Preconditioning(a) Hypoxic Preconditioning
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After HypoxiaAfter Hypoxia
Before HypoxiaBefore Hypoxia
After ReoxygenationAfter Reoxygenation
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(b) Genetic Manipulation(b) Genetic Manipulation
e.g. Viral mediated e.g. Viral mediated
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Engineered MSCs transdifferentiate into CMs
Circulation Res. Vol 99, 776-84. 2006
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Transplantation of Modified Stem Cells
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Scar tissue
Heart Attack
Blocked blood vessel
Dead muscle
Myocardial infarction
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Isolation of Mesenchymal Isolation of Mesenchymal Stem Cells from ratsStem Cells from rats
Infarction Model in Infarction Model in RatsRats
Functional Functional StudiesStudies
Cell Cell TransplantationTransplantation
HistologHistologyy
RatRat
Chemical or Genetic Chemical or Genetic ModificationModification
Cell Transplantation
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Myogenic transdifferentiationof MSC at 4 weeks after cell transplantation
FITC actinin staining Red PKH26 staining
DAPI Nuclear staining Merge
Circulation Res. Vol 99, 776-784. 2006
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ReferencesReferences
Cardiovasc Ther. 2012 Jun 15. doi: 10.1111/j.17555922.2012.00320.x
Circulation Res. Vol 99, 776-84. 2006