cd40l concentration-dependently binds to mac-1's i-domain. wolf d et al. circulation research...
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![Page 1: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/1.jpg)
CD40L concentration-dependently binds to Mac-1's I-domain.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association
![Page 2: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/2.jpg)
CD40L binds to a distinct binding site within the Mac-1 I-domain.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association
![Page 3: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/3.jpg)
The peptide inhibitor cM7 specifically interferes with CD40L-Mac-1 binding.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association
![Page 4: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/4.jpg)
CD40L-Mac-1 interaction drives leukocyte recruitment in vivo.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association
![Page 5: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/5.jpg)
Specific blockade of the CD40L-Mac-1 interaction attenuates atherosclerosis in mice.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association
![Page 6: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/6.jpg)
Inhibition of the CD40L-Mac-1 dyad reduces macrophage and lipid accumulation in atherosclerotic lesions.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association
![Page 7: CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109:1269-1279 Copyright © American Heart Association](https://reader033.vdocuments.us/reader033/viewer/2022061306/5514676b5503462d4e8b5be6/html5/thumbnails/7.jpg)
CD40L-Mac-1 interaction does not mediate thrombus formation and stability in mice.
Wolf D et al. Circulation Research 2011;109:1269-1279
Copyright © American Heart Association