car t nomenclature and positioning-2
TRANSCRIPT
CAR-T: Market Perspectives April 15, 2015 Brand Acumen The Global Leader in Pharmaceutical Name Development
CAR-T: Market Positioning
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The purpose of this presentation is to examine the CAR-T market landscape with an eye on brand positioning, market messaging and current external perceptions. The contents include a high level overview of the nomenclature and nascent brand architecture of the primary companies, a review of the evolving CAR-T lexicon, and the results of a CAR-T specific Brand Equity Perception Study conducted in March, 2015.
Differentiation Dimensions
Overview: The CAR-T
Nomenclature and Nascent Brand
Architecture
Brand Acumen’s CAR-T
Brand Equity Perception Study
March, 2015
A Review of the Evolving
CAR-T Lexicon
Celyad Transposagen Cellular Biomedicine Carsgen Unum Caribou Biosciences Xcyte WuXi Atara
CAR-T émergent nomenclature
corp
orat
e br
ands
CAR-T a new lexicon
chimeric antigen receptor therapy
Surv
ey D
esig
n
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To initiate the CAR-T Brand Equity Study we surveyed five segments of Key Innovation Leaders (KILs). • Bio Industry Writers (8) • Venture Capitalists (7) • Oncologists (35) • CAR-T Specific Researchers (21) • Market Makers/Analysts (12)
CAR-T Brand Equity Perception Study
Brand Acumen’s CAR-T Brand Equity survey methodology brings together market, brand, competitive, and technological attribute perceptions. A corporate brand’s performance can be assessed allowing for a roadmap for improvement to be identified in micro-niche biotech ecosystems.
sample size/
number of respondents
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
chimeric antigen receptor therapy
CAR-T: The Main Players A Review of Company Nomenclature and Results of the Brand Acumen CAR-T Brand Equity Perception Study
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
tisagenlecleucel-T
Alternative Names: • Anti-CD19-CAR retroviral vector-transduced autologous T
cells - University of Pennsylvania
• Anti-CD19-CAR transduced T cells - Novartis/University of Pennsylvania
• CART-019; CART-19; CART-19 cells
• Chimeric antigen receptor-modified T cells against CD19 - University of Pennsylvania/Novartis
• CTL 019
• LG-740
Most Recent Events 26 Feb 2015 Phase-II clinical trials in Diffuse large B cell lymphoma in USA (IV) (Novartis, pipeline, February 2015) 08 Dec 2014 Efficacy data from a pediatric study in Acute lymphoblastic leukemia presented at the 56th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2014) 15 Oct 2014 Interim efficacy and adverse events data from two phase I trials in Acute lymphoblastic leukemia (second-line therapy or greater) released by University of Pennsylvania
tisa – gen – lec – leu – cel - T generic name
• MesoCART • huCART19
non-proprietary name
CRISPR/Cas9
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score.
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
Sleeping Beauty RheoSwitch®
plat
form
bra
nds
AttSite® UltraVector®
LEAP®
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score.
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
Lentiglobin® Lenti-D® Starbeam Study North Star Study
branded clinical studies
brands
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
eACT™
T-Cell Factory B.V.
acqu
isiti
on
collaboration
plat
form
bra
nd
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score.
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
CaspaCIDe™ CIDeCAR™ GoCAR-T™ DeCIDe™
brands
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score.
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
Armored CAR technology technology brand
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score.
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
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CAR-T nomenclature
@Na
scen
t CAR
-T N
omen
clat
ure
pipeline identifier brand UCART
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score.
CAR-
T Br
and
Equi
ty P
erce
ptio
n St
udy
Each of the six attribute categories are scored from 0-100 with 0 being the lowest and 100 the highest score. The scores are weighted based on respondents answers to quantitative and qualitative criteria.
evolutionary. revolutionary. disruptive.
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