Cancer Care Engineering

Joe Pekny, PhD Visionary

Marietta Harrison, PhD Worker Bee

Cancer Care EngineeringCurrent Funding Initiatives

Walther Cancer Institute Foundation

Engineering the Cancer System (R-CCE)

Funded: $1.35M Regenstrief Institute 7/1/07-2009

Focused on Health Services Research

• Cancer Care Delivery, Modeling & Data Visualization, CCEHub

Warfighter CCE (W-CCE)

Funded: $2.4M DOD, 12/1/07-2011

Focused on Prevention, Molecular Signatures

•Sample Acquisition, OMIC Analysis, Data Modeling, Data Visualization, Literature Mining

Funded: $0.2M 2007-2009

Dog-CCE (D-CCE)

Regenstrief, PCC, DP, Engineering, Vet School

Funded: $0.2M 2007-2009

Cancer Care Engineering

Vision: to harness goal-oriented research to solve the cancer problem using Indiana as model for the nation

Approach: create an engineering “Systems Analysis” model for cancer prevention, detection, treatment and care delivery

Team: Over seventy physicians, caregivers, engineers, scientists and staff drive the CCE vision

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Cancer Care Engineering

The Integrated Pillars

Mathematical Models

Patient OMIC Analysis

Health Services Research

Cancer as a Managed Disease

Cancer Care Engineering

Predictive Biomarkers “OMICS”

Patient Blood

• Genomic Analysis

• Lipidomic

• Metabolomic

• Glycoproteomic

Cancer Care Engineering

Critical Enablers

• Interactive Databases

-CCEHub

• Visualization

Cancer Care Engineering

Mathematical Models

Statistical

Semi-mechanistic

• Population-based

• Agent-based