CACHE Systems CACHE Systems Biology Task ForceBiology Task Force

Fall Trustee MeetingFall Trustee Meeting

Nashville, TNNashville, TNNovember 2009November 2009

Systems Biology Task Systems Biology Task ForceForce

Develop educational materials for the Develop educational materials for the undergraduate ChE curriculumundergraduate ChE curriculum

Provide training opportunities for Provide training opportunities for graduate students interested in systems graduate students interested in systems biology researchbiology research

Increase the visibility of systems biology Increase the visibility of systems biology in ChE educationin ChE education

Offer the Foundations of Systems Biology Offer the Foundations of Systems Biology in Engineering (FOSBE) conference in Engineering (FOSBE) conference seriesseries

Task Force MembersTask Force Members Mike Henson (UMass, Chair)Mike Henson (UMass, Chair) Frank Doyle (UCSB)Frank Doyle (UCSB) Vassily Hatzimanikas (EPFL)Vassily Hatzimanikas (EPFL) Marianthi Ierapetritou (Rutgers)Marianthi Ierapetritou (Rutgers) Claire Komives (San Jose State)Claire Komives (San Jose State) Costas Maranas (Penn State)Costas Maranas (Penn State) Tunde Ogunnaike (Delaware)Tunde Ogunnaike (Delaware) Bob Parker (Pittsburgh)Bob Parker (Pittsburgh) Linda Petzold (UCSB)Linda Petzold (UCSB) Chen Su (Eli Lilly)Chen Su (Eli Lilly) Dane Wittrup (MIT)Dane Wittrup (MIT)

Bold indicates CACHE trusteeBold indicates CACHE trustee

FOSBE 2009FOSBE 200933rdrd Conference on Conference on

Foundations of Systems Foundations of Systems Biology in EngineeringBiology in Engineering

Denver, ColoradoDenver, ColoradoInverness Hotel & Conference Inverness Hotel & Conference

CenterCenterAugust 9-12, 2009August 9-12, 2009

www.fosbe.org

Sponsored by CACHE and the Sponsored by CACHE and the Systems Biology Task ForceSystems Biology Task Force

Technical Program & Technical Program & SponsorsSponsors

SundaySunday MondayMonday TuesdayTuesday WednesdayWednesday

MorninMorningg

TraininTraining g WorkshWorkshopop

Drug Drug DevelopmentDevelopment

Network Network ModelingModeling

Circadian Circadian SystemsSystems

AfternoAfternoonon

TraininTraining g WorkshWorkshopop

Free timeFree time Federal Federal Funding PanelFunding Panel

Free timeFree time

EveninEveningg

ReceptiReceptionon

Alternative Alternative FuelsFuels

EducationEducation Synthetic Synthetic BiologyBiology

NightNight KeynoteKeynote Poster Poster Session ISession I

Poster Session Poster Session IIII

Award Award Ceremony & Ceremony & BanquetBanquet

Student Training Student Training WorkshopWorkshop

ObjectivesObjectives Tutorial introductions to several important Tutorial introductions to several important

areas of systems biologyareas of systems biology Targeted at graduate students, post-doctoral Targeted at graduate students, post-doctoral

researchers & young faculty entering the fieldresearchers & young faculty entering the field Further CACHE goal of providing educational Further CACHE goal of providing educational

trainingtraining StructureStructure

7 leading systems biology researchers & 7 leading systems biology researchers & practitionerspractitioners

5 academic speakers covering theoretical 5 academic speakers covering theoretical topics & important applicationstopics & important applications

2 industrial speakers covering systems 2 industrial speakers covering systems biology impact in the pharmaceutical industry biology impact in the pharmaceutical industry

Workshop SpeakersWorkshop Speakers Mathematical Modeling Methodology at Amgen Mathematical Modeling Methodology at Amgen

(David Balaban, Amgen)(David Balaban, Amgen) Network Robustness (Frank Doyle, UCSB )Network Robustness (Frank Doyle, UCSB ) An Example of How Systems Biology is An Example of How Systems Biology is

Contributing to Drug Discovery in the Contributing to Drug Discovery in the Pharmaceutical Setting (Bruce Gomes, Pfizer)Pharmaceutical Setting (Bruce Gomes, Pfizer)

Bioenergetics and Biochemical Network Bioenergetics and Biochemical Network Thermodynamics (Vassily Hatzimanikatis, EPFL)Thermodynamics (Vassily Hatzimanikatis, EPFL)

Circadian Entrainment and Rhythm Generation Circadian Entrainment and Rhythm Generation (Erik Herzog, Washington U and Hiroki Ueda, (Erik Herzog, Washington U and Hiroki Ueda, Kyushu U)Kyushu U)

Stochastic Chemical Kinetics (Dam Gillespie, Stochastic Chemical Kinetics (Dam Gillespie, Gillespie Consulting)Gillespie Consulting)

Parameter Estimation and Structure Identification Parameter Estimation and Structure Identification in Metabolic Networks (Eberhard Voit, Georgia in Metabolic Networks (Eberhard Voit, Georgia Tech)Tech)

Workshop OutcomesWorkshop Outcomes AttendanceAttendance

42 total attendees42 total attendees 19 graduate & post-doctoral students19 graduate & post-doctoral students 11 professors, mostly assistant professors11 professors, mostly assistant professors 1 industry attendee1 industry attendee 3 federal government attendees3 federal government attendees

FeedbackFeedback Overall response very positiveOverall response very positive Several attendees felt the workshop was the Several attendees felt the workshop was the

most valuable portion of the conferencemost valuable portion of the conference Future plansFuture plans

Gathering presentations for website postingGathering presentations for website posting Second workshop planned at FOSBE 2011Second workshop planned at FOSBE 2011

Task Force UpdateTask Force Update Tunde OgunnaikeTunde Ogunnaike

Accepted position as task force chairAccepted position as task force chair Decided not to run for trustee re-electionDecided not to run for trustee re-election Mike Henson will assume chair positionMike Henson will assume chair position

Have mainly focused on FOSBE 2009 & Have mainly focused on FOSBE 2009 & 20112011

Possible initiativesPossible initiatives Change task force members and expand focusChange task force members and expand focus Distribution of materials from Bioengineering Distribution of materials from Bioengineering

Educational Materials Bank (Educational Materials Bank (www.bioEMB.net)) Preparation of NIH proposal for educational Preparation of NIH proposal for educational

modulesmodules