bundle of fibers muscle fiber (muscle cell) myofibril sarcomere

Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

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Bundle of fibers

Muscle fiber (muscle cell)

Myofibril Sarcomere

Myosin filamentActin filament

Relaxed

Partially contracted

Fully contracted

Z- line Z- line

M- disk

A band

H Zone

Myofibril

I band I bandA band

H ZoneZ line Z line

One Complete Sarcomere

M line

Page 4: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

Actin TroponinTropomyosin

Thin filament organization

Page 5: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

Myosin Tail(-helix coiled coil)

Myosin Head

Myosin light chains(LC1, LC2)

Page 6: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

M-disk Region

Page 7: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

Page 8: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

ATP binding causes release of myosin from actin

ATP

Page 9: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

Hydrolysis of ATP

ADPPi

Conformational change“cocking of myosin head”

Page 10: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

ADPPi Formation of myosin/actin

crossbridge

Page 11: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

“Power Stroke”

ADP

Release of ADP and Pi

Page 12: Bundle of fibers Muscle fiber (muscle cell) Myofibril Sarcomere

High Ca2+

Ca2+

channelCa2+

pump

Ca2+/calmodulin

MLCKMLCK-Ca2+

(active)

Myosin/MLC(relaxed)

Myosin/MLC- P(contraction)

ATP ADP

Pi H2O

MLC phosphatase

MLCK- P(inactive)

MLCK phosphatase

Epinephrinereceptor

Epinephrine

G Protein

Adenylatecyclase

ATP

cAMPR2C2 Protein kinase

(inactive)

2C Protein kinase

(active)

Electrical stimulation

Monocyte membrane

Figure 46-19 Sarcomere Myofibril Dark bandLight band Relaxed Contracted Muscle tissue Bundle of muscle fibers (many cells) Muscles Muscle fiber (one cell)

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