buck institute for age research review of the nathan shock center of excellence in basic biology of...
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Buck Institute for Age Research
Review of the Nathan Shock Center of Excellence in Basic Biology of Aging
at the
Buck Institute for Age Research
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What are Nathan Shock Centers?
First RFA -- 1999 Support Admin core, 2 or more research resource cores,
research development coreEnhance basic biology of aging research; establish regional/national
resources; enhance aging research environment for junior/other investigators
Second RFA -- 2004 Fund research and training related to the basic biology of aging
Intended for institutions with substantial investment in/commitment to aging research
Not intended to support clinical research
Third RFA -- 2009 Applications due early May, 2009
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1999 -- four centers funded (U Michigan, U Rochester, U Texas San Antonio, U Washington)
Buck Institute applied (same yr Buck opened)
2004 -- five centers funded (Buck Institute, Jackson Labs, U Michigan,
U Texas San Antonio, U Washington)
2009 -- # to be funded unknown (Buck's competitive renewal)
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Buck Institute's Nathan Shock Center(organization)
Director and PI -- Dale Bredesen (Buck CEO)Transferred to Campisi July, 2008
Administrative Core (Bredesen/Campisi)
Four research Cores:Animal/transgenic (Kerby/McDonald, Zhang)
Genomics (Melov)Proteomics (Gibson)
Imaging (Nicholls/Brand)
Research & Development Core (Greenberg)
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Buck Institute's Nathan Shock Center(resource allocation)
Awarded Requested
Total award (yr 1): $383 K 633 K
Administrative core: $52 K 86 KAnimal/transgenic core: $60 K 100 KGenomics core: $60 K 101 KProteomics core: $61 K 102 KImaging core: $51 K 85 KResearch/development core: $99 K 157 K
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Buck Institute's Nathan Shock Center(activities)
Annual Buck symposium (partial)
Special courses (2-3/yr)
Weekly seminar series (6/yr)
High school internships (2/yr)
Pilot projects (2/yr)
Core activities
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Buck Institute's Nathan Shock Center(future plans)
Continue support for:
Research and Development Core
(Annual symposium -- partial Seminars -- 4-6 Courses -- 2-3
Pilot projects -- at least 2)
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Buck Institute's Nathan Shock Center(future plans)
Continue support for:
Animal core
(Reduced emphasis on transgenicsExpand with small animal imaging)
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Buck Institute's Nathan Shock Center(future plans)
Continue support for:
Genomics core
(Incorporate SOLID sequencingLunyak as co-director)
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Buck Institute's Nathan Shock Center(future plans)
Continue support for:
Proteomics core
(Biomolecular Mass Spectrometry CoreExpand to include lipid, carbohydrate analyses)
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Buck Institute's Nathan Shock Center(future plans)
Continue support for:
Imaging core
(Bioenergetics and Imaging CoreExpand to include Seahorse analyses)
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Buck Institute's Nathan Shock Center(future plans)
Continue support for:
Imaging core
(Bioenergetics and Imaging CoreExpand to include Seahorse analyses)
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Buck Institute's Nathan Shock Center(future plans)
Establish new core:
Small molecule screening core
(Bob HughesTools for drug discovery
Tools for animal model testingTools for pathway identification)