Following the opening of the Mel-

lanby Centre on 9th June 2009, this

year saw the 1st Annual Mellanby

Centre Research Day. Held in the

Medical School on 10th June, we

hosted 120 delegates, including at-

tendees from both industry and

charity. Speakers included Dr Fiona

McGuigan, Malmö University Hospi-

tal, Sweden; Professor Ted Gross,

University of Washington, USA;

Professor Graham Williams, Imperial College London; Dr Tarran Jones,

MRC Technologies; and Professor Bo Abrahamsen, University of Southern

Denmark. The Day included a successful evening social event held at the

Rutland Hotel with live jazz music provided by Andy Chantry’s quintet.

With thanks to our kind sponsors E2V Scientific Instruments, Lilly, Med-

tronic, ONO Pharma, Roche and Warner Chilcott. Plans for the second

meeting to be held mid 2011 are underway. http://www.mellanbycentre.dept.shef.ac.uk/

In Brief

Mellanby Centre day

NIHR portal

Project updates

Lay Advisory Panel

update

Staff news

Team building event

Meetings attended

Recent publications

Collaborations

Upcoming meetings

Mellanby Centre Research Day

The NIHR recognises that NIHR-funded bodies usually comprise an eclectic

mix of people and organisations dispersed across a range of locations. This is

certainly true of the Bone BRU, with staff employed by either the Sheffield Teaching Hospital NHS Foundation Trust or the University of Sheffield and

located in various buildings across Sheffield’s hospitals and university campuses. To improve internal communications, they have launched the new

NIHR Portal, which uses Microsoft SharePoint 2007 and is accessible from any PC linked to the internet. It provides a central point for storing, sharing and

accessing all documents, reducing the administrative burden and helping staff to

directly access the information they need. The Bone BRU has a dedicated and restricted access area on the NIHR portal for sharing documentation relating

to clinical trials management, research projects, research ethics and govern-ance, along with training resources, a shared interactive calendar and other

useful admin tools. The Bone BRU is currently creating repositories of docu-ment and picture libraries, presentation materials and training resources, whilst

running user training and feedback assessments to ensure the portal

facility is designed to best meet the needs of the Bone BRU.

Bone Biomedical Research Unit

Newsletter

September 2010

Introducing the NIHR Portal

The public face of the portal does not require

any log-on information. It provides news and infor-

mation about the NIHR as well as links to services

and sites of interest to

the research community (such as funding opportu-

nities) and can be found at www.nihr.ac.uk.

Please contact Kath

Knight for further infor-

mation(Katharine.knight@sth.nh

s.uk)

Projects

XtremeCT We successfully recruited 180 study participants

within 12 months and completed our first study

using the XtremeCT device, which was purchased

using BRU capital funding. With this high-res

quantitative computed tomography device we

were able to show that the bones of the arms and

legs continue to increase in size after the end of

longitudinal growth, that both men and women

lose bone with ageing and that bone loss is mainly

due to perforation of trabecular plates in women

and thinning of trabecular plates in men.

This work has been accepted for presentation at

the American Society for Bone and Mineral Re-

search (ASBMR) annual conference in October.

Additional analyses planned on these data will ex-

amine the cortical porosity of the tibial and radial

bones. Finite element analysis will also be per-

formed to further examine the micro-

architectural properties of bone.

The purchase of this XtremeCT scanner, one of

only three in the country, has helped the Bone

BRU become the UK’s leading centre in this area

of research and we look forward to updating you

with our research findings.

Future projects:

Studying the build-up of new bone in response

to a currently available anabolic therapy

(teriparatide)

3D images of the

radius a

(a) 30 year old man

(b) 72 year old

woman

Studying the serotonin excess effects on bone in

carcinoid patients

Looking at the effects of obesity on bone struc-

ture and strength

Investigating the relationship between serum

oestradiol and vertebral fracture risk.

Fracture Risk Assessment Pathway Vertebral fractures are a common problem, particu-

larly in post-menopausal women, which can lead to a number of health problems including back-pain,

height loss, and deformity, and are associated with significant morbidity and increased mortality. 20% of

women with vertebral fractures will experience an-

other within a year.

Vertebral fracture assessment (VFA) is a low-risk imaging technique, that uses much less radiation than

spinal radiography. It has been comprehensively evaluated by our research team and was introduced

into clinical practice in Sheffield in August 2008 as

part of an innovative one-stop diagnostic pathway. This 10 second scan can be used to visually identify

vertebral fractures at the same time as measuring bone mineral density (BMD), an important indicator

of osteoporosis. This has helped reduce unneces-sary clinical investigations whilst enhancing risk as-

sessment. Staff at the Metabolic Bone Centre, lead

by Dr Nicky Peel, are now working to implement the Fracture Liason Service. The aim of this is to

work with fracture clinics, trauma wards, depart-ments of Occupational Therapy and Physiotherapy,

and A&E to identify all men and women over the age of 50 presenting with new fractures. Nurse-led tri-

age within the MBC will offer appointments to all

patients considered “at risk”, who will then enter in to the FRAS pathway.

The MBC has

recently been awarded the Brit-

ish Society for

Rheumatology Osteoporosis

Award 2010 for their work in

fracture risk as-

sessment.

September 2010 Page 2

Bone BRU Newsletter

Projects cont.

Tibial strain and vibration therapy We have now received approval to begin recruit-

ment for research in to the relationship between

tibial strain and limb displacements in healthy vol-

unteers during vibration exercise and habitual

locomotor activities. This study, led by Profes-

sor Eugene McCloskey, will also document the

transmission of the vibration stimulus to other

parts of the skeleton.

Pharmacologic osteoporosis treatments reduce

fracture risk by 25 to 50%, but in advanced dis-

ease, fracture risk remains high due to irreversi-

ble losses of bone structure. There are data to

support a critical role for mechanical stimulation

in improving or maintaining skeletal integrity but

previous studies in humans have been limited due

to poor understanding of the strains induced in,

and their transmission through, the skeleton.

By surgically implanting strain gauges on to the

tibia, we will be able to record tibial bone strain

during vibration therapy as well as during a range

of habitual locomotor activities. We can also

record the transmission of vibrations and deter-

mine the muscle power in the lower limb associ-

ated with various habitual locomotor activities

and the relationship to the measured tibial bone

strain.

With the data recorded from 5 healthy volun-

teers, we plan to construct models of the tibia

The TRIO study is a novel study, comparing

the effects of 3 bisphosphonates (alendronate,

risedronate and ibandronate) at a variety of bone

sites. Alendronate is currently prescribed due to

its lower price; however both risedronate and

ibandronate will come off patent shortly, and

prices are expected to fall in line with alendro-

nate. Results of this trial are therefore expected

to inform clinical decision-making for treatment

of osteoporosis in the future.

As part of our agreement with the School of

Health and Related Research (ScHARR) to pro-

vide clinical trial databases, data management, and

statistical support we now have a fully functional

web-based clinical trials database for our TRIO

and TRIO offset studies. The TRIO data moni-

toring committee was formed to hold an inde-

pendent review of the safety data and primary

endpoint data collected so far, which is to be

held in the new clinical trials database. The first

data monitoring committee meeting was held in

April 2010 and attended by Professor Coleman,

Professor Ross and Professor Eastell, along with

2 statisticians from ScHARR, Mike Bradburn and

Neil Shephard, and the Bone BRU manager, Kath

Knight. Prof Rob Coleman led a review of the

results and data presented by the statisticians

from ScHARR and the committee concluded that

there were no significant issues in relation to the

number or frequency of adverse events recorded

in the trial.

Preliminary findings will be further evaluated in a

planned interim analysis that will be completed in

October 2010.

The Power Plate Pro5, an example of one of the 3 vibration plat-forms that will be used in this study.

based upon architectural data, material proper-

ties and strain which will form the beginnings of

an evidence base for the skeletal effects of vibra-

tion therapy. Future implications for our work

include the potential to target common sites of

fracture, to achieve the full anabolic response

with lower doses or shorter duration of drug

therapy and to help maintain improvements in

bone mass and structure.

September 2010 Page 3

Bone BRU Newsletter

Lay Advisory Panel for Bone Research

Active involvement

The Panel is currently engaged in carrying out a

survey of patients attending the Metabolic Bone

and Orthopaedic clinics at the Northern General

Hospital. The aim of the survey is to

find out more about patient views on

research, particularly with regards to

engaging the public in clinical trials.

Panel members were involved in the

survey design and are now working

with staff to collect responses to the

survey using handheld PDAs (personal

digital assistants). Responses are then

relayed to a central computer and

data analysis will be carried out by the Picker In-

stitute Europe. We have been invited to give an

oral presentation of the results of this work in a

workshop session at the INVOLVE conference in

Nottingham in November. Several Panel mem-

bers will attend the conference and contribute to

the workshop.

The main role of the Lay Advisory Panel for

Bone Research over the past year has been to

review our research protocols and participant

information leaflets. The review process is inter-

active and involves a presentation by the study

Principal Investigator followed by a question and

answer session with the Panel

members. The Panel then prepares

a written review of the study,

focusing on participant related

issues. Investigators have found

the feedback from the Panel to be

a very useful preparation for the

ethics review.

Since the last Bone BRU newslet-

ter, the work of the Panel has

been promoted nationally in an article published

by INVOLVE. The article, written by a Panel

member, appeared in their Summer 2010 edition

newsletter. Dr Angela Rogers attended the Bio-

medical Research, Patient and Public Involve-ment Workshop in April and was consequently

invited to speak to Joan Saddler, Director of Pa-

tient and Public Affairs and at the INVOLVE

Group Meeting in London in June this year.

Page 4

“the work of the Panel has

been promoted nationally in an

article, written by a panel

member, published by INVOLVE

in their Summer 2010 edition

newsletter”

September 2010

Bone BRU Training Programme

Launched in January 2010, this programme has been designed with the inten-

tion that everyone who trains and works in our unit will be equipped with the

knowledge and skills to achieve their aims and develop expertise that will be

useful in the future. This multi-disciplinary programme is available to every-

one: staff, BMedSci students, PhD students and research fellows.

The programme has three tiers which run concurrently—designed to ensure

that we meet everyone’s needs. Inductions are run each time we have new

trainees in the department, and guarantee new personnel are accredited and

safe to work. The core sessions extend over one year and cover the impor-

tant areas of bone metabolism, as well as providing support with some ge-

neric skills such as writing, presentating and statistics. The advanced pro-gramme runs over two years, and is intended to build on the core pro-

gramme to develop greater knowledge of bone metabolism and related areas.

The first block of the training has now been completed, and feedback from

tutors and participants has indicated that it has so far been a success. Details

about the programme can be found on the NIHR portal at

https://portal.nihr.ac.uk/Welcome/Pages/NewWelcome.aspx.

Research Funding

The International

Osteoporosis Founda-

tion and i3 innovus

have funded Sheffield to

coordinate the UK

section of the study

ICUROS (The Interna-

tional Costs and

Utilities Related to Os-

teoporotic Fractures

Study). This study

started in March 2010

and is led by Professor

McCloskey.

Bone BRU Newsletter

Paul Dimitri

We welcome

Dr Paul Dimitri

as an NIHR

Clinical Fellow

at the Bone

BRU. He is also

a Consultant in

Paediatric En-

docrinology at

Sheffield Children's Hospital. Paul’s PhD research

focused on fat and bone mass in children, exam-

ining the relationships between fat-derived hor-

mones, osteokines and bone turnover. He is cur-

rently involved in projects studying bone in chil-

dren with single gene obesity syndromes and in

adolescents with anorexia nervosa.

Paul.Dimitri@sch.nhs.uk

Scott MacInnes

Dr Scott MacInnes has joined us an NIHR Clini-

cal Fellow, and is working with Mr Mark Wilkin-

son.

scottmacinnes@doctors.org.uk

Lucy Harris

Lucy completed her Biomedical Science degree at

the University of Sheffield and now joins us as a

PhD student. She is supervised by Prof Eugene

McCloskey and will be working on the new clini-

cal trial studying the strains exerted by mechani-

cal vibration on the tibia. She will also be com-

paring the exerted strains to those induced by

habitual activities and observing their effects on

BMD.

mdp10lch@sheffield.ac.uk

Katherine Andrews

Katherine joined us in Septem-

ber as an Editorial Research

Assistant. She comes to us

from BioMed Central where she worked as an Editorial As-

sistant, aiding in the administer-

ing of the peer review process,

before joining the Post-

Publication Production Department. In this role,

People

BMedSci Students

Matt Clark

Matt is supervised by Mr

Mark Wilkinson, and his

project focuses on the

systemic effects of metal

ion release after hip re-

surfacing. The project is

a continuation of a study

carried out in 2009. It

involves the analysis of

clinical imaging and bio-logical samples taken

from 35 matched pairs of men and women who

have previously had either a total hip replace-

ment or hip resurfacing. The project also in-

cludes continued recruitment of women into the

study, collecting their data and further analysis.

Matt has completed his 2nd year in Medicine, and

envisions a future in Orthopaedics. He is origi-

nally from Newcastle, and enjoys playing rugby

and loves to watch all sports. mda08mjc@shef.ac.uk

Ed Harlock

Ed is supervised by

Mr Mark Wilkinson,

and will be studying

the functional effect

of genetic variation in

the failure of hip

prostheses, which is

usually due to oste-

September 2010 Page 5

Bone BRU Newsletter

she was responsible for ensuring correct conver-

sion of manuscripts from PDF to HTML format,

and reformatting figures and tables in XML.

Katherine’s role in the Bone BRU will be to assist

the work of the Research Programme Managers,

Lynne Ferrar and Angela Rogers, helping to co-

ordinate meetings, to upload and maintain infor-

mation on the websites, produce the newsletter

and provide editorial assistance.

K.Andrews@sheffield.ac.uk

olysis. He will be investigating how

these variations cause changes in cyto-

kine production in various cell lines.

Hailing from Ripon, and a big YCCC

fan, as well as rugby and football, Ed

hopes to complete his medical degree

and work to become a surgeon.

mda08eh@sheffield.ac.uk

Alice Manley

Alice is working

on a joint project

between the 2

BRUs, supervised

by Prof Richard

Eastell and Dr

Chris Newman.

Her work forms

part of the Car-

diovascular sub-

study of the Fat and Bone Study. The

aim of this is to find out if there is an interaction between cardiovascular

risk and fracture risk in individuals

aged between 55 and 75 years. She

will be evaluating cardiovascular risk

factors and assessing fracture risk.

mdc07am@sheffield.ac.uk

Rachel Stansfield

Rachel is undertaking

the second of the joint

BRU projects super-

vised by Prof Richard

Eastell and Dr Chris

Newman. Her project

is entitled “Bone and

Collagen Turnover

markers in Acute

Coronary Syndrome

and Pulmonary

People

Team-Building

22 April

Halifax Hall,

The Edge,

Endcliffe Village

37 staff attended

our team-building

workshop with Isabelle Read of

Ashbridge

Consulting. The

purpose of this

event was to

discuss ideas on

how to make the

BRU successful at

all levels, both as a

respected research

facility, and as a

connected, friendly

working

environment.

The event enabled

us to set up a social

committee and find

ways to include all

staff in work and

social aspects;

review building

facilities; celebrate

our recent

achievements and

discuss ways to

source new funding

and improve our

publication record

for our continued

success.

“How to

make the

BRU

success f u l a t

a l l l e ve ls . ”

Hypertension” and she will work on

the value of collagen degredation

markers after myocardial infarction to

study healing.

In her spare time, Rachel is making

the most of living on the fringes of the

Peak District, frequently walking in

the National Parks or catching up

with course-mates. She hopes to con-

tinue in research in the future.

mdc08rs@sheffield.ac.uk

Will JM Udall

Supervised by Dr

Lang Yang, Will is

working on a

project entitled

“Hip structure

and finite element

analyses of Hip

QCT scans for

assessing the hip

fracture risk". As

part of the MRC Biomarker project,

50 postmenopausal women with re-

cent hip fracture and 50 matched con-

trols were recruited. Will is to per-

form hip structure and finite element

analyses on the quantitative computed

tomography (QCT) scans of the hip. Will chose to leave his native New-

castle to study in Sheffield partly due

to the climbing opportunities pre-

sented around the city, and he cur-

rently runs the Medics bouldering

club. Will would like to pursue a ca-

reer in Orthopeadics following a 9

week placement at the NGH last

year.

mda07wju@sheffield.ac.uk

Don’t forget!!

September 2010 Page 6

Bone BRU Newsletter

February

British Hip Society Conference, Sheffield Oral: Effect of Cobalt and Chromium Ions on the

Formation and Function of Human Peripheral Blood Derived Osteoclasts in-vitro.* Rebecca Andrews

*Presidents prize

Oral: Effect of Cemented Prosthesis Geometry on Bone Remodelling of the Proximal Femur: A Random-

ised Clinical Trial. Mark Wilkinson

March National Late Effects of Cancer Confer-

ence, Sheffield Oral: Optimum oestrogen replacement in the young

survivor.* Jenny Walsh *Best abstract prize

Symposium: Bone health after cancer

Eugene McCloskey-Chair

British Endocrine Society Meeting, Man-chester

Oral: Quality of life in CAH. Richard Ross

Orthopaedic Research Society Meeting, New Orleans

Oral: Effect of Sliding-Taper versus Composite-Beam Femoral Prosthesis Loading Regime on Periprosthetic

Bone Mass and Turnover after Total Hip Arthroplasty: A Randomized Clinical Trial. Mark Wilkinson

Poster: Serum C-terminal Telopeptide of Type I

Collagen, a Matrix Metalloproteinase-Derived Colla-gen Degradation Product, is a Sensitive Biomarker for

Detecting Periprosthetic Osteolysis. Mark Wilkinson

14th International Conference, Japan Oral: New aspect of CAH/adrenal insufficiency. Rich-

ard Ross

April Adrenal Meeting ,Turin

Oral: Optimal glucocorticoid therapy. Richard Ross

June ENDO 2010, San Diego,

Oral: Optimizing Replacement Therapy for Adrenal

Insufficiency. Richard Ross

Bone Research Society Meeting, London Poster: The effect of Cobalt(II) and Chromium(VI)

on the proliferation and activity of SaOs-2 os-teoblast cells in vitro. Rebecca Andrews

European Calcified Tissue Society, Glas-

gow Oral: Efficacy and safety of the Cathepsin K inhibi-

tor, ONO-5334, in the treatment of postmeno-pausal osteopenia or osteoporosis. Richard Eastell.

Poster: Reduced risk of colon cancer death in pa-

tients treated with alendronate—National Register based cohort study. B. Abrahamsen et al.

Poster: Subtrochanteric and diaphyseal fractures in

patients during long-term alendronate treatment: expanded and extended National Register based

cohort studies. B Abrahamsen et al.

Poster: Relationships between osteoporosis medica-tion adherence, surrogate marker outcomes and

non-vertebral fracture incidence. Richard Eastell

Poster: What accounts for inadequate response to Zoledronic acid? Richard Eastell.

Poster: Effect of calcium-fortified ice cream on

bone turnover in young women. Lynne Ferrar

Poster: The percentage reduction in vertebral frac-ture risk with lasofoxifene explained by change in

spine bone mineral density. R Jacques et al.

Poster: Optimum oestrogen replacement in the young survivor. Jennie Walsh

Workshop: Using DXA for vertebral fracture

analysis. Lynne Ferrar

Meet the Professor Session: FRAX and interven-tion thresholds. Eugene McCloskey

Symposium: Risk assessment and treatment op-

tions of primary and secondary osteoporosis in 2010. Eugene McCloskey

September 2010 Page 7

Meetings

Bone BRU Newsletter

Arlt W, Willis DS, Wild SH, Krone N, Doherty

EJ, Hahner S, Han TS, Carroll PV, Conway GS,

Rees DA, Stimson RH, Walke BR, Connell JM,

Ross RJ; the United Kingdom Congenital Adrenal

Hyperplasia Adult Study Executive (CaHASE).

Health Status of Adults with Congenital Adrenal

Hyperplasia: A Cohort Study of 203 Patients. J

Clin Endocrinol Metab. 2010 Aug 18. [Epub ahead

of print]

Black DM, Kelly MP, Genant HK, Palermo L,

Eastell R, Bucci-Rechtweg C, Cauley J, Leung PC,

Boonen S, Santora A, de Papp A, Bauer DC;

Fracture Intervention Trial Steering Committee;

HORIZON Pivotal Fracture Trial Steering Com-

mittee. Bisphosphonates and fractures of the sub-

trochanteric or diaphyseal femur. N Engl J Med.

2010; 362(19):1761-71

Borgström F, Ström O, Kleman M, McCloskey

EV, Johansson H, Odén A, Kanis JA. Cost-

effectiveness of bazedoxifene incorporating the

FRAX(R) algorithm in a European perspective.

Osteoporos Int. 2010 Jun 8. [Epub ahead of print]

Cummings SR, Ensrud K, Delmas PD, LaCroix

AZ, Vukicevic S, Reid DM, Goldstein S, Sriram U,

Lee A, Thompson J, Armstrong RA, Thompson

DD, Powles T, Zanchetta J, Kendler D, Neven P,

Eastell R; PEARL Study Investigators. Laso-

foxifene in postmenopausal women with osteo-

porosis. N Engl J Med. 2010; 362(8):686-96

Eastell R, Christiansen C, Grauer A, Kutilek S,

Libanati C, McClung MR, Reid IR, Resch H, Siris

E, Uebelhart D, Wang A, Weryha G, Cummings

SR. Effects of denosumab on bone turnover

markers in postmenopausal osteoporosis. J Bone

Miner Res. 2010 Sep 13. [Epub ahead of print]

Eastell R, Rogers A, Ni X, Krege JH. Effects of

raloxifene and alendronate on bone turnover as

assessed by procollagen type I N-terminal

Publications

propeptide. Osteoporos Int. 2010 Sep 14. [Epub

ahead of print]

Emms NW, Stockley I, Hamer AJ, Wilkinson JM.

Long-term outcome of a cementless, hemispheri-

cal, press-fit acetabular component. Journal of

Bone and Joint Surgery - British Volume. 2010; 92-B

(6):856-861

Evangelou E, Valdes AM, Kerkhof HJM, Styrkars-

dottir U, Zhu YY et al. Meta-analysis of genome-

wide association studies confirms a susceptibility

locus for knee osteoarthritis on chromosome

7q22. Ann Rheum Dis (in press)

Gauthier A, Kanis JA, Martin M, Compston J,

Borgström F, Cooper C, McCloskey EV; On be-

half of the Committee of Scientific Advisors, In-

ternational Osteoporosis Foundation. Develop-

ment and validation of a disease model for post-

menopausal osteoporosis. Osteoporos Int. 2010

Aug 11. [Epub ahead of print]

Gordon A, Greenfield EM, Eastell R, Kiss-Toth E,

Wilkinson JM. Individual susceptibility to pe-

riprosthetic osteolysis is associated with altered patterns of innate immune gene expression in

response to pro-inflammatory stimuli. J Orthop

Res. 2010; 28(9):1127-35

Johansson H, Odén A, Kanis J, McCloskey EV,

Lorentzon M, Ljunggren O, Karlsson MK, Orwoll

E, Tivesten A, Ohlsson C, Mellström D. Low

bone mineral density is associated with increased

mortality in elderly men: MrOS Sweden. Osteopo-

ros Int. 2010 Jun 29. [Epub ahead of print]

Johansson H, Kanis JA, McCloskey EV, Odén A,

Devogelaer JP, Kaufman JM, Neuprez A, Hiligs-

mann M, Bruyere O, Reginster JY. A FRAX(R)

model for the assessment of fracture probability

in Belgium. Osteoporos Int. 2010 Mar 30. [Epub

ahead of print]

September 2010 Page 8

Bone BRU Newsletter

We’ve had a very successful publication run in 2010, with two articles published in the New England

Journal of Medicine, as well as 4 articles published in the top speciality journals within our field,

Journal of Clinical Endocrinology and Metabolism, and Journal of Bone and Mineral Research.

Kanis JA, Johansson H, Oden A, McCloskey EV.

A meta-analysis of the efficacy of raloxifene on all

clinical and vertebral fractures and its depend-

ency on FRAX. Bone. 2010; 47(4):729-35

Leslie WD, Lix LM, Johansson H, Oden A,

McCloskey E, Kanis JA; Manitoba Bone Density

Program. Independent clinical validation of a Ca-

nadian FRAX((R)) tool: Fracture prediction and

model calibration. J Bone Miner Res. 2010 Apr 30.

[Epub ahead of print]

McCloskey EV, Paterson A, Kanis J, Tähtelä R,

Powles T. Effect of oral clodronate on bone

mass, bone turnover and subsequent metastases

in women with primary breast cancer. Eur J Can-

cer. 2010; 46(3):558-65

Murphy E, Glüer CC, Reid DM, Felsenberg D,

Roux C, Eastell R, Williams GR. Thyroid function

within the upper normal range is associated with

reduced bone mineral density and an increased

risk of nonvertebral fractures in healthy euthy-

roid postmenopausal women. J Clin Endocrinol Me-

tab. 2010; 95(7):3173-81

Paggiosi MA, Glueer CC, Roux C, Reid DM, Fel-

senberg D, Barkmann R, Eastell R. International

variation in proximal femur bone mineral density.

Osteoporos Int. 2010 Jul 15. [Epub ahead of print]

Paggiosi MA, Clowes JA, Finigan J, Naylor KE,

Peel NF, Eastell R. Performance of Quantitative

Ultrasound Measurements of Bone for Monitor-

ing Raloxifene Therapy. J Clin Densitom. 2010 Sep

16. [Epub ahead of print]

Peel NM, Travers C, Bell RA, Smith K. Evaluation

of a health service delivery intervention to pro-

mote falls prevention in older people across the

care continuum. J Eval Clin Pract. 2010 Aug 15.

[Epub ahead of print]

Ström O, Borgström F, Kleman M, McCloskey

EV, Odén A, Johansson H, Kanis JA. FRAX and

its applications in health economics—cost-

effectiveness and intervention thresholds using

Publications bazedoxifene in a Swedish setting as an example.

Bone. 2010; 47(2):430-7

Verma S, Vanryzin C, Sinaii N, Kim MS, Nieman

LK, Ravindran S, Calis KA, Arlt W, Ross RJ,

Merke DP. A pharmacokinetic and pharmacody-

namic study of delayed- and extended-release

hydrocortisone (Chronocort) vs. conventional

hydrocortisone (Cortef) in the treatment of con-

genital adrenal hyperplasia. Clin Endocrinol (Oxf).

2010; 72(4):441-7

Walsh JS, Henry YM, Fatayerji D, Eastell R. Hor-

monal determinants of bone turnover before and

after attainment of peak bone mass. Clin Endocri-

nol (Oxf). 2010; 72(3):320-7.

Review

Coleman RE, Walsh JS. Bone: causes of low bone

mass in breast cancer-time for action? Nat Rev

Endocrinol. 2010; 6(1):10-2

Eastell R, Newman C, Crossman DC. Cardiovas-

cular disease and bone. Arch Biochem Biophys.

2010 Jun 11. [Epub ahead of print]

Kanis JA, McCloskey EV, Johansson H, Oden A,

Ström O, Borgström F. Development and use of

FRAX in osteoporosis. Osteoporos Int. 2010; 21

Suppl 2:S407-13

Stone B, Dockrell D, Bowman C, McCloskey EV.

HIV and bone disease. Arch Biochem Biophys.

2010; 503(1):66-77

Walsh JS, Henriksen DB. Feeding and bone. Bio-

chem Biophys. 2010; 503:11-19.

Editorial

McCloskey EV. Calculating fracture risk in pri-

mary care. Practitioner. 2010; 254(1725):7

Letter

McCloskey EV, Compston J, Cooper C. The US

FRAX filter: avoiding confusion or hindering pro-

gress? Osteoporos Int. 2010; 21(5):885

September 2010 Page 9

Bone BRU Newsletter

Monthly BRU Group Meetings

27th September

1st November

6th December

Seminar Room,

Centre for Biomedical Research

13.30-16.00

We welcome all your news and views, so drop

us a line if you have anything you want to include

in the November newsletter. Deadline for con-

tributions is 1st November. bonebru@sheffield.ac.uk

Recent Collaborations

Publication of our first joint paper with the

Cardiovascular BRU (Eastell, Newman &

Crossman, 2010)

2 joint Bone/Cardiovascular BRU BMedSci

projects

Extending research into Paediatrics with ap-

pointment of Dr Paul Dimitri

Working with ScHARR to provide clinical trail

databases

Monthly meetings with the endocrinology re-

searchers

Joint funding of the Biorepository with the

Medical School

Upcoming Meetings

ASBMR Annual Meeting

15-19 October, Toronto

http://www.asbmr.org/Meetings/

AnnualMeeting.aspx

ISCD and IOF FRAX® Initiative:

"Interpretation and Use of FRAX® in Clinical

Practice",

11-13 November, Bucharest

http://event.ascendys.ch/

NOS Osteoporosis Conference

28 Nov-1 Dec. Liverpool

http://www.nos.org.uk/NetCommunity/

Page.aspx?pid=300

3rd Joint meeting of BRS and BORS

27-29 June 2011, Cambridge

Registration opens Nov 2010

September 2010 Page 10

Bone BRU Newsletter

PPI Seminars

The benefit of involving patients and the public in

research has become increasingly recognised and is now a requirement for seeking National Institute of Health Research (NIHR) funding.

You are invited to attend any of the following semi-nars: 10th November, 12:30-13:30 in MBC Seminar Room, NGH - Dr Nicola Peel

18th November, 12:30-13:30 Lecture Theatre, Jes-sop Wing - Dr Simon Palfreyman 25th November, 17:30-18:30 Large Committee Room, Weston Park Hospital - Dr Angela Rogers & Professor Simon Heller

Please email Nicola Redfearn by Friday 22nd October

2010 confirming which seminar you wish to attend. Nicola.redfearn@sth.nhs.uk

Items of Esteem

Mr Mark Wilkinson was appointed to the Board

of Directors of the Orthopaedic Research Soci-

ety in the United States for the term 2010-2011.

He was also appointed Chair of the Special Pro-

jects Committee of the society and sits on its

Professional Development and Mentoring Coun-

cil.

Prof Eugene McCloskey has been appointed chair

of one of 3 task-forces created by the joint IOF

and ISCD committee to improve the FRAX® tool.