blood physiology 1432 lecture 3 leucocytes 1 professor a m abdel gader md, phd, frcp (lond., edin),...
TRANSCRIPT
![Page 1: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/1.jpg)
![Page 2: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/2.jpg)
Blood Physiology1432
Lecture 3
Leucocytes 1
Professor A M Abdel GaderMD, PhD, FRCP (Lond., Edin), FRSH (London)
Professor of Physiology, College of Medicine &the Blood Bank, King Khalid University Hospital
King Saud UniversityRiyadh
![Page 3: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/3.jpg)
![Page 4: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/4.jpg)
LeucocytesWhite Blood Cells
(WBCs)
![Page 5: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/5.jpg)
Objectives of Lecture -3At the end of this lecture the student should be able to:1.Describe the different types of WBCs2.Recognize the general functions of WBCs3.Describe the genesis and site of formation of WBCs4.Describe the stages of neutrophil formation5.Describe the role of the neutrophil in defending the body against infections6.Describe the process of phagocytosis
![Page 6: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/6.jpg)
Leucocytes (WBCs)Contents
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis– Structure and function of Eosinophils and
basophils
![Page 7: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/7.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis– Structure and function of Eosinophils and
basophils
Leucocytes (WBCs)Contents
![Page 8: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/8.jpg)
Blood Film
![Page 9: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/9.jpg)
![Page 10: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/10.jpg)
Hematopoiesis
![Page 11: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/11.jpg)
Formed Elements of Blood• Red blood cells ( erythrocytes )• White blood cells ( leukocytes )
– granular leukocytes• neutrophils• eosinophils• basophils
– agranular leukocytes• lymphocytes = T cells, B cells, and natural killer
cells• monocytes
• Platelets
![Page 12: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/12.jpg)
Leucocytes (WBCs) – cont.
General Characteristics & types of WBCs
• Types of WBC1. Granular (polymorphnuclear):
• Neutrophil 62%.– 10-16um, nucleus 2-5 lobes, purple
cytoplasmic granules
• Eosinophil 2.3%.– 12-18um, 2 lobes nucleus, coarse red
granules
• Basophil 0.4%.– 10-14um, rarely segmented nucleus,
nucleus hidden by large round bluish granules
![Page 13: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/13.jpg)
Leucocytes (WBCs) – cont.
General Characteristics & types of WBCs
• Types of WBC2. Agranular WBC
– Monocytes 5.3%• 15-20um, kidney shape nucleus
– Lymphocyte 30%• round nucleus
– small (5-8um) – large (9-15um)
![Page 14: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/14.jpg)
![Page 15: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/15.jpg)
![Page 16: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/16.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
Leucocytes (WBCs)-cont.
Contents
![Page 17: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/17.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
Leucocytes (WBCs)-cont.
Contents
![Page 18: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/18.jpg)
Leucocytes (WBCs) – cont.
Genesis (Production) of WBCs
Pluripotential stem cell
Committed Stem cell
RBCs WBCs Platelets
Mylocytic Lymphocytic Linage Linage
![Page 19: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/19.jpg)
Figure 16-5c: Bone marrow
![Page 20: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/20.jpg)
Hematopoiesis
![Page 21: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/21.jpg)
21
![Page 22: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/22.jpg)
Leucocytes (WBCs) – cont.
Genesis (Production) of WBCs- leucopoiesis)
Sites of WBC formation• Granulocytes (neutrophil, basophil,
eosinophil):
– bone marrow
• Agranulocytes – lymphocytes- bone marrow,
thymus, lymphoid tissues– monocytes- bone marrow
![Page 23: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/23.jpg)
23
![Page 24: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/24.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
Leucocytes (WBCs)-cont.
Contents
![Page 25: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/25.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
Leucocytes (WBCs)-cont.
Contents
![Page 26: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/26.jpg)
Life Span of WBCs
Granulocytes:• 4 to 8 hrs (transit time ) in blood circulation• 4 to 5 hrs in tissues
– In infections life span a few hours
Monocytes :– 10 to 20 hrs in blood circulation– Leave capillaries to tissues, increase in size
to become tissue macrphages which live for months
![Page 27: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/27.jpg)
Life Span of WBCs-cont.
Lymphocytes:
• A few hrs in blood circulation >> tissues >> lymph >>> Blood (Recirculation)
?Life span: weeks to months
![Page 28: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/28.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
Leucocytes (WBCs)-cont.
Contents
![Page 29: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/29.jpg)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils (& macrophages)
– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
Leucocytes (WBCs)-cont.
Contents
![Page 30: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/30.jpg)
Leucocytes (WBCs)
• General Characteristics & types of WBCs• Genesis (Production) of WBCs• Life Span of WBCs• Defense properties of neutrophils &
macrophages– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
![Page 31: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/31.jpg)
Defense properties of neutrophils (& macrophages)
• Attack and destroy bacteria, viruses
• Sequence of events:– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
![Page 32: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/32.jpg)
![Page 33: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/33.jpg)
Netrophils function-cont.
Defense properties of neutrophils & macrophages-cont
Phyagocytosis: Engulfing and killing of bacteria or any
invading organism
Steps: Chemotaxis:
– Bacterial & viral toxins• Products of damaged tissues:
attract neutrophil to accumulate at infected site.
– Opsonization: plasma substances (IgG) attached to the bacteria to make them easy to phagocyte
![Page 34: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/34.jpg)
Diapedesis
![Page 35: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/35.jpg)
Diapedesis
http://www.whfreeman.com/immunology/CH01/diapedesis.htm
![Page 36: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/36.jpg)
Defense properties of neutrophils & macrophages
• Attack and destroy bacteria, viruses
• Sequence of events:– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
![Page 37: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/37.jpg)
![Page 38: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/38.jpg)
Defense properties of neutrophils & macrophages
• Attack and destroy bacteria, viruses
• Sequence of events:– Chemotaxis– Diapedesis– Amaeboid Motion– Phagocytosis
![Page 39: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/39.jpg)
Phagocytosis- cont.
Phagocytosis is selective:Distinguish self from non-self…... How?
– Normal tissues have smooth surface– Normal tissues have protective
protein surface– Antibodies coating bacteria
(Opsonization)
![Page 40: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/40.jpg)
Phagocytosis
![Page 41: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/41.jpg)
Microbial killing
41
![Page 42: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/42.jpg)
Phagocytosis by neutrophils- cont.
Neutrophils attach to bacteria & encircled it with pseudopodia and take it into a vacuole (phagosome).
• One Neutrophil can engulf 3 to 20 bacteria• One Macrophage can engulf up to 100 bacteria
Microbial killing: fusion of neutrophil granules with vacuole,
– Discharge of lysozyme, myeloperoxidase enzymes into the vacuole, killing and digesting the engulfed bacteria.
– Release of Free radicals by oxidizing agents: superoxide, hydrogen peroxide to kill the bacteria
![Page 43: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/43.jpg)
![Page 44: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/44.jpg)
Leucocytes (WBCs) – cont.
• Types of WBC1. Granular (polymorphnuclear):
• Neutrophil 62%.– 10-16um, nucleus 2-5 lobes, purple
cytoplasmic granules
• Eosinophil 2.3%.– 12-18um, 2 lobes nucleus, coarse red
granules
• Basophil .4%.– 10-14um, rarely segmented nucleus,
nucleus hidden by large round bluish granules
![Page 45: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/45.jpg)
Blood Film
![Page 46: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/46.jpg)
Eosinophils
Function: • Phagocytosis: Phagocytosis is same as neutrophil,
but less efficient
• Chemotaxis: eosinophil attracted towards chronic inflammation/allergic tissue (allergic disease of skin & lungs)
By eosinophil chemotactic factor
Phagocytose (& detoxify) antigen/antibody complexes
![Page 47: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/47.jpg)
Eosinophils cont,
•High eosinophil count:– Parasitic (hook worm, ascaris,
bilharzia)– Allergic (asthma, rhinitis, drug
reaction)– Allergic skin diseases
![Page 48: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/48.jpg)
Leucocytes (WBCs) – cont.
• Types of WBC1. Granular (polymorphnuclear):
• Neutrophil 62%.– 10-16um, nucleus 2-5 lobes, purple
cytoplasmic granules
• Eosinophil 2.3%.– 12-18um, 2 lobes nucleus, coarse red
granules
• Basophil .4%.– 10-14um, rarely segmented nucleus,
nucleus hidden by large round bluish granules
![Page 49: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/49.jpg)
Leucocytes (WBCs) – cont.
• Types of WBC1. Granular (polymorphnuclear):
• Neutrophil 62%.– 10-16um, nucleus 2-5 lobes, purple
cytoplasmic granules
• Eosinophil 2.3%.– 12-18um, 2 lobes nucleus, coarse red
granules
• Basophil .4%.– 10-14um, rarely segmented nucleus,
nucleus hidden by large round bluish granules
![Page 50: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/50.jpg)
Blood Film
![Page 51: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/51.jpg)
Basophils
• Similar to tissue mast cells• Non-phagocytic cells• Granules: dark blue color.• Granules contain:
– Heparin– Histamine – Serotonin (5HT).
Released during allergic reactions
![Page 52: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/52.jpg)
Objectives of Lecture -3At the end of this lecture the student should be able to:1.Describe the different types of WBCs2.Recognize the general functions of WBCs3.Describe the genesis and site of formation of WBCs4.Describe the stages of neutrophil formation5.Describe the role of the neutrophil in defending the body against infections6.Describe the process of phagocytosis
![Page 53: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/53.jpg)
![Page 54: Blood Physiology 1432 Lecture 3 Leucocytes 1 Professor A M Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of](https://reader033.vdocuments.us/reader033/viewer/2022051001/56649eb35503460f94bbb466/html5/thumbnails/54.jpg)
THANK YOU
جزيل لكمالشكر