bipn 148 lecture 16. remembering jennifer anniston
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BIPN 148 Lecture 16
RememberingJennifer Anniston
Activate Visual and Auditory Neurons
Stimulate Hippocampal Neurons
Visual Somatosensory
Olfactory
Auditory
Perirhinal Cortex
Entorhinal Cortex
Dentate GyrusCA3
CA1
Sensory RegionsOf Cortex
Perirhinal/ Entorhinal
Cortex
HippocampalFormation
Get info from cortex to hippocampus
Stimulate hippocampal synapses
Activate Spines
Potentiate Synapses
Activate CaMKII
Phosphorylate AMPA receptors
Phosphorylate GluR1on S831
Insert GluR1 at synapses
Unsilence synapses
Use Stargazin to traffic AMPA-R
Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.
Induce gene expression
Use CaMKIV to induce gene expression
CRE SRE zif268
C/EBP krox20
AMPARHOMERBDNFNT-3
Arc
CBP/CREB
CaMKIV + ERK
Elk-1
RSK2
Express new genes
New gene products or
proteins
Signal to
nucleus
New gene products or
proteins
Synaptic Potentiation
Locally generated tag captures new gene product
Synaptictag
NMDAR
Send gene products to synapse
RememberingJennifer Anniston
Activate visual & auditory neurons
Stimulate hippocampal neurons
Change synaptic strengthby inserting AMPA receptorsInduce gene expressionStabilize change in synaptic strengthRecall image with visual cueDon’t confuse with Angelina Jolie