Biomanufacturing

in North Carolina

Biomanufacturing in N.C.

What is biotechnology?

A collection of technologies that use

living cells and/or biological

molecules to solve problems and make

useful products.

Biomanufacturing in N.C.

The making of these products is

called biomanufacturing or

bioprocessing.

Biomanufacturing in N.C.

A Growing Industry in N.C.

16 biomanufacturing companies

More than 30 other companies engaged in related manufacturing of pharmaceuticals, diagnostics and medical devices

Together, they employ more than 20,000 people.

Biomanufacturing in N.C.

Types of products made in N.C. include:

Vaccines for humans and animals

Biopharmaceuticals

Amino acids

Industrial enzymes

Therapeutics isolated from blood

Custom DNA sequences

Biogen Idec

Produces biopharmaceuticals to treat cancer,

multiple sclerosis and inflammatory diseases.

Its large-scale manufacturing in

Research Triangle Park

is one of the largest

cell culture facilities

in the world.

Ajinomoto Is a world leader in the

production of amino acids,

the building blocks of

proteins. Like many

bioprocessing facilities, the

Raleigh plant operates

at full capacity

24 hours a day,

365 days a year.

Is a world leader in production of

recombinant protein

biopharmaceuticals. Its state-of-the-art

facilities are located in Research

Triangle Park.

Diosynth RTP

AlphaVax Is developing a new

vaccine technology with

broad applications

against infectious

disease, cancer and

biodefense threats. Its

manufacturing plant is

located in Lenoir.

Novozymes North America

Is located on 1,600 acres

in Franklinton. It is the

largest multi-purpose

enzyme manufacturing

plant in the United States

and employs

approximately

350 people.

Novozymes is the biotech-based world leader in

industrial enzymes and microorganisms.

Embrex Is an international ag

biotech company that

developed the first in ovo

(in the egg) injection

system. It eliminates the

need for manual

vaccination of newly

hatched broiler chicks.

The manufacturing plant

is located in

Laurinburg.

Wyeth Vaccines

Operates one of the

world’s largest

vaccine facilities in

Sanford. The

vaccines that

eliminated small

pox and polio in the

U.S. came from

Wyeth laboratories.

Greer Labs Is a leading supplier

of allergy testing

and treatment

materials. Its

manufacturing

facility is located in

Lenoir.

KBI BioPharma Is a contract

biomanufacturer in Durham. The

company produces a

variety of bio-pharmaceuticals

for other companies.

MWG Biotech

Offers products and services for gene

research.

The company produces custom DNA sequences.

The facility is located in

High Point.

Argos Therapeutics Is developing

therapeutic

vaccines in

Durham, which are

given to treat

(instead of

prevent) diseases

such as cancer

and HIV/AIDS.

Biolex Produces hard-to-

make therapeutic proteins by growing them in the aquatic

plant Lemna (duckweed).

The biomanufacturing plant is in Pittsboro.

Isolates a variety of therapeutic proteins

from human blood and plasma in its

Clayton, N.C., facility.

The diseases these proteins treat

include:

● Hemophilia

● Clotting disorders

● Shock ● Burns

● Immune disorders

● Hepatitis ● Tetanus

● Rabies exposure.

Talecris Biotherapeutics

Archer Daniels Midland

Is one of the largest agricultural processors in the world. The plant, in Southport, N.C., produces citric acid.

Corn Products International

Produces high-

fructose corn syrup and starch

in Winston-Salem.

Merck & Co. Broke ground on a new

biomanufacturing

facility in 2004. When

completed in 2008,

the Durham facility

will produce vaccines

for chicken pox and

measles-mumps-

rubella (MMR).