BIOGEN IDEC’S NEW SCIENTIFIC WORKSPACE MODEL Ed Dondero & Werner Meier 2013 Intl Conference on Research Facilities – Boston, MA

At first we shape our buildings, thereafter our buildings shape us…... Winston Churchill

A Closer Look: Biogen Idec

Through cutting-edge science and medicine, we discover, develop and deliver to patients worldwide innovative therapies for neurodegenerative diseases, autoimmune disorders and hemophilia

We have one of the industry’s most robust late-stage pipelines with more than a dozen programs in clinical development

Our three blockbuster products AVONEX, TYSABRI and RITUXAN

TECFIDERA is fourth US product, a first-line oral treatment for people with relapsing multiple sclerosis

Founded in 1978, we are the world’s oldest independent biotechnology company that today has a rapidly-expanding global footprint and employs nearly 6,000 people worldwide

Robust Pipeline Consistently Growing

AVONEX (INTERFERON BETA-1A) TYSABRI (NATALIZUMAB)

RITUXAN (RITUXIMAB) FUMADERM (FUMARIC ACID ESTERS)

FAMPYRA (PROLONGED-RELEASE FAMPRIDINE TABLETS) TECFIDERA (DIMETHYL FUMARATE)

RECOMBINANT FACTOR IX Fc (rFIXFc) RECOMBINANT FACTOR VIII Fc (rFVIIIFc)

PEG IFN (PEGYLATED INTERFERON BETA-1A) DACLIZUMAB-HYP

GA101 (HUMANIZED ANTI-CD20 MAB) GA101 (HUMANIZED ANTI-CD20 MAB)

TYSABRI (NATALIZUMAB) OCRELIZUMAB (HUMANIZED ANTI-CD20 MAB)

ANTI-TWEAK ANTI-LINGO

STX-100 NEUBLASTIN

CD40L BIIB037 (HUMAN ANTI-AMYLOID BETA MAB)

SMNrx

PHASE 1 PHASE 2 PHASE 3 FILING APPROVED

Growing Global Footprint

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With operations in 29 countries, direct commercial capabilities in 27, and a distributor network and partnerships that extend our commercial reach to more than 70 additional markets, Biogen Idec has established a global footprint that allows us to capture the greatest value for the products we develop.

Background

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20 year old facility

150, 000 SF six story plus basement

Constant Volume Mechanical System

Academic model for Biology and Chemistry labs

(6) 12 person modules per floor

1:2 lab office to tech ratio

Dedicated equipment

Common equipment and support

What Did We Do?

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► Initiated Lab design with unique interview process

► Macro – building view

► Micro – lab module view

►Prioritized challenges

► Demolition and reconstruction of the interior of existing B6 lab building (150,000SF)

►New mechanical system

►Horizontal and vertical communication

►Convert existing adjacent office space (B6A) to lab

Why We Did What We Did

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Infrastructure

► Lack of spontaneous interaction

► Aging MEP infrastructure

► High energy consumption

► Enviable! (natural light)

Efficiency

► Consolidation of acquired lab functions to Cambridge campus

► Compliance

► Chemicals

► Food and drink

► Inability to rapidly accommodate evolving technologies

► Reduce orphaning

Why We Did What We Did - Orphaning

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How We Did It? the Process

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Assemble Team

Metrics

Data Collection Visioning

Lab Tenets

Lab Concepts

Approvals

Design

New Office

How We Did It? - Visioning

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►Engaged design partner

►Joint visioning exercise

► Output = Establish Tenets • Full Utilization of lab floors, accommodating

groups of varying sizes and needs such that no seats are “orphaned”

• Adaptable Design, allowing changes in function, equipment, layout, and group sizes without major disruption or investment.

• Visibility, openness and access to natural light within and between labs and offices.

• Increase in collaborative space, easily accommodating both scheduled and spontaneous sharing of data, ideas and energy.

Assemble Team

Metrics

Data Collection Visioning

Lab Tenets

Lab Concepts

Approvals

Design

New Office

How We Did It? – Data Acquisition

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►Acquired existing condition data

► Lab reviews

► User interviews

► Output = Developed metrics

Assemble Team

Metrics

Data Collection Visioning

Lab Tenets

Lab Concepts

Approvals

Design

New Office

ExistingOffice (SF) 6,987

Lab 7,609Lab Support 3,556

Total Lab (SF) 11,165

Bench & Equipment (LF) 1,425

How We Did It? – Concepting/Approval

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►Concepting

§ Lab, Office and hybrid centric

►Proofing

► Incorporate new office workplace settings

► Recommend preferred option through inclusive process

§ Working group (users)

§ Governance Team

§ Senior Management (EVP level)

Assemble Team

Metrics

Data Collection Visioning

Lab Tenets

Lab Concepts

Approvals

Design

New Office

Lab Planning Options

Lab Centric

Pro’s Full office integration Visibility and openness

Con’s

3 distinct Lab zones Lab area stretched Limits casual interaction to office area

Pro’s Full lab and office consolidation

Casual interactions

Con’s Longer distance from desk to lab bench

Pro’s Full lab consolidation Adaptable lab design Openness

Con’s 3 distinct office zones Linear desk orientation Limited casual interaction to lab area

Office Centric Hybrid

How We Did It? – Data Acquisition

Existing Lab Centric Office Centric Hybrid Office (SF) 6,987 8,351 8,246 9,140

Lab 7,609 8,697 8,371 8,501Lab Support 3,556 1,978 2,178 1,700

Total Lab (SF) 11,165 10,675 10,549 10,201

Bench & Equipment (LF) 1,425 1,164 1,278 1,464

How We Did It? – Design

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Assemble Team

Metrics

Data Collection Visioning

Lab Tenets

Lab Concepts

Approvals

Design

New Office

Lab layout – Minimal fixed structures

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Bldg infrastructure

Emergency showers

Sink and eye wash

PPE (de)gowning/

Primary circulation

Secondary circulation

Office/Lab separation

Lab layout – Minimal fixed structures

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How We Did It? – Open Concept “I” Space

6’ x 8’ typical workstation 6’ x 4’ typical lab tech bay

• A more open concept that creates visual connection • Panels and componentry of sufficient height to balance privacy but not impede collaboration • Easily accessible wire management • A lighter, airier aesthetic

6x4 workstations - 42

6x8 workstations - 27

“I” Space

Office layout – Open concept “I” Space

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How We Did It? – Open Concept “We” Space

Collaboration Learning

Concentrative Connecting

“We” spaces

How We Did It? – New Office

Collaboration Enclosed, private space that enables project teams and groups to concentrate and focus and even reserve for extended periods of time

Learning Technology-enhanced meeting spaces for larger groups that helps users create, capture, display, store, and retrieve information

How We Did It? – New Office

Concentrative

Enclosed space where an individual can get away to make a phone call, have a confidential conversation with a co-worker or privacy and quiet for heads down concentrated work

Connecting

Primary thoroughfare that links different spaces and facilitates interaction as it draws people through the environment

Office layout – Open concept

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Learning

Concentrating

Collaborating

Connecting

“We” Space

Office layout – “We” Space – Connecting - Collaborating

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Wrap-up

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Acknowledgements

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Bill Harris Andy Goetze Steve Webster Jeannie Thacker Sallyann Thomas Tagore Hernandez Kristine Dudley Jane Kepros Rich Quinby

Paul Norris Serena Bodner Cherie Butts Baisong Mei

Glenn Bernard Harris Zeidman Mike Bakis Robert Chavez

Carrie Hawley Robyn Goldstein

Carl Nelson

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To be continued……