beth israel president's reception
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December 1, 2009: Your body as a self healing ecosystem...TRANSCRIPT
Stem Cell Therapies and Regeneration:
Your Body as a Self-Healing Ecosystem
Neil Theise, MDDepartments of Pathology and Medicine
Beth Israel Medical Center - Albert Einstein College of MedicineNew York City
www.neiltheise.com
this talk: Posted on slideshare.net (search “theise”)
December ‘99
January ’00December ‘99
LethalIrradiation
Male Bone Marrow Transplant
FISH forY-Chromosome
July ’00January ’00December ‘99
Controversy!!!
Sort PKH-brightSort PKH-bright
Male Donor BMMale Donor BM
Lin DepleteLin DepleteElutriateElutriate
PKH26PKH26LabelLabel
48 Hours48 Hours
Transplant Transplant singlesingle cell into cell into 22oo Female Recipient Female Recipient
11oo Female Recipient Female Recipient
Bone Marrow
One Adult Cell
Epithelia of • Liver• Lung• Gut, (Pancreas)
Skin, Hair follicles
MESODERM
ENDODERM ECTODERM
One Adult Cell
One Adult Cell
Adult cells can do whateverembryonic cells can do!
MESODERM
ENDODERM ECTODERM
One Adult Cell
One Adult Cell
The Standard Paradigm ofEmbryology & Adult Tissue Repair
The Revised Paradigm
Controversy!!!
trivial...trivial...vs.vs.
ROBUST!!!ROBUST!!!
Meanwhile, Meanwhile, back at the stem cell debates…back at the stem cell debates…
trivial vs. robust...?trivial vs. robust...?
Conversations with Jane ProphetNew Media Artist and
Professor, Interdisciplinary StudiesUniversity of Westminster, London UK
SciArt Award, Wellcome Trust 2002
Conversations with Jane ProphetNew Media Artist and
Professor, Interdisciplinary StudiesUniversity of Westminster, London UK
SciArt Award, Wellcome Trust 2002
Date: 9th May 2002 Location: Neil's office, New York
Jane says: “Ideas about pathways are interesting. A Jane says: “Ideas about pathways are interesting. A lot of people who are involved in digital biology are lot of people who are involved in digital biology are interested in things like swarming people and so interested in things like swarming people and so called ’soup organism’ behaviour. And one of the called ’soup organism’ behaviour. And one of the
useful models to take forward is about ant useful models to take forward is about ant colonies…”colonies…”
Complex Adaptive Systems:
Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed. Chicago IL: University of Chicago Press; 2002.
Johnson S, Emergence. New York NY: Scribner; 2001.
…
Complex Adaptive Systems:Interacting individuals that,
if they fulfill 4 criteria,organize themselves from the bottom up,
into larger structures
Complex Adaptive Systems:Interacting individuals that,
if they fulfill 4 criteria,organize themselves from the bottom up,
into larger structures that appear planned from the top, downward,
Complex Adaptive Systems:Interacting individuals that,
if they fulfill 4 criteria,organize themselves from the bottom up,
into larger structures that appear planned from the top, downward,
BUT ARE NOT!
Complex Adaptive Systems:Interacting individuals that,
if they fulfill 4 criteria,organize themselves from the bottom up,
into larger structures that appear planned from the top, downward,
BUT ARE NOT!
These self organizing structures are ADAPTIVE.ADAPTIVE.
Complex Adaptive Systems:Rise and Fall of Economic Markets
Urban DevelopmentImmune Systems
BeatlemaniaRise and Fall of Civilizations
Coral ReefsEvolution and Speciation
Complex Adaptive Systems:
• Numbers matter
Complex Adaptive Systems:
• Numbers matter
• Negative feedback loops
Complex Adaptive Systems:
• Numbers matter
• Negative feedback loops
• Interactions are local without global sensing
Complex Adaptive Systems:
• Numbers matter
• Negative feedback loops
• Interactions are local without global sensing
• Low level randomness
Low level engraftment Low level engraftment is not only NOT trivial, is not only NOT trivial, but it is VITAL but it is VITAL – – literally so.literally so.1-31-3
Low level engraftment Low level engraftment is not only NOT trivial, is not only NOT trivial, but it is VITAL but it is VITAL – – literally so.literally so.1-31-3
11Theise ND. Exp Hematology 2003Theise ND. Exp Hematology 200322D’Inverno M, Theise ND. BCMD 2004D’Inverno M, Theise ND. BCMD 200433D’Inverno M, Theise ND, Prophet J.D’Inverno M, Theise ND, Prophet J.
In: Potten C, Wilson J, Clarke R, Renahan A: In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applicationsTissue stem cells: Biology and applications
Hierarchies of complex systems…
thing vs. phenomenon
depends on scale of observation
How does this relate to disease and injury?
HEARTHEARTATTACK!!!ATTACK!!!
STEMSTEMCELLSCELLS
STEMSTEMCELLSCELLS
STEMSTEMCELLSCELLS
Stem Cells!Stem Cells!
Stem Cells!Stem Cells!
Here at Beth Israel(in collaboration with NeoStem, Inc)
The Team:Drs. Theise, Karpeh, and Bodenheimer
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPDwith Dr. Jonathan Raskin, Pulmonary Medicine
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
with Dr. Martin Karpeh, Chair of Surgery
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Projects in exploration/planning stages: End stage liver disease (cirrhosis) Type I diabetes
Here at Beth Israel(in collaboration with NeoStem, Inc)
Grant applications now submitted for:
Emphysema/COPD Chronic non-healing cutaneous wounds
Projects in exploration/planning stages: End stage liver disease (cirrhosis) Type I diabetes
In the future…? What interests you…? Talk to me!
More…
2006 Conference:Longevity & Optimal Health
Integrating Eastern & Western Perspectives
GLOBAL mind/body interventions
e.g. YOGA, MEDITATION, etc….
GLOBAL mind/body interventions
Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
e.g. YOGA, MEDITATION, etc….
GLOBAL mind/body interventions
LOCAL effects
Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking
Site Specific, Tissue Regeneration
e.g. YOGA, MEDITATION, etc….
Still more…
Communities
BodiesCells
e.g. cities, cultures, ecosystems, Gaia
BodiesCells
If our parks are the lungs of the city…?If our parks are the lungs of the city…?
Are our hospitals its organs of healing and regeneration?Are our hospitals its organs of healing and regeneration?