be280a 06 mri2 - university of california, san diego · be280a_06_mri2.ppt author: thomas liu...
TRANSCRIPT
![Page 1: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/1.jpg)
1
TT Liu, BE280A, UCSD Fall 2006
Bioengineering 280APrinciples of Biomedical Imaging
Fall Quarter 2006MRI Lecture 2
TT Liu, BE280A, UCSD Fall 2006
GradientsSpins precess at the Larmor frequency, which isproportional to the local magnetic field. In a constantmagnetic field Bz=B0, all the spins precess at the samefrequency (ignoring chemical shift).
Gradient coils are used to add a spatial variation to Bzsuch that Bz(x,y,z) = B0+Δ Bz(x,y,z) . Thus, spins atdifferent physical locations will precess at differentfrequencies.
![Page 2: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/2.jpg)
2
TT Liu, BE280A, UCSD Fall 2006
Simplified Drawing of Basic Instrumentation.Body lies on table encompassed by
coils for static field Bo, gradient fields (two of three shown),
and radiofrequency field B1.
MRI System
Image, caption: copyright Nishimura, Fig. 3.15
TT Liu, BE280A, UCSD Fall 2006
Z Gradient Coil
B(mT)
L
Credit: Buxton 2002
![Page 3: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/3.jpg)
3
TT Liu, BE280A, UCSD Fall 2006
Gradient Fields
!
Bz(x,y,z) = B0
+"Bz
"xx +
"Bz
"yy +
"Bz
"zz
= B0
+Gxx +Gyy +Gzzz
!
Gz
="B
z
"z> 0
!
Gy ="Bz
"y> 0
y
TT Liu, BE280A, UCSD Fall 2006
Interpretation
∆Bz(x)=Gxx
Spins Precess atat γB0+ γGxx(faster)
Spins Precess at γB0- γGxx(slower)
x
Spins Precess at γB0
![Page 4: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/4.jpg)
4
TT Liu, BE280A, UCSD Fall 2006
Gradient Fields
!
Gx x + Gy y + Gzz =r G "
r r
!
r G "Gx
ˆ i + Gyˆ j + Gz
ˆ k
!
Bz(r r ,t) = B
0+
r G (t) "
r r
Define
!
r r " xˆ i + yˆ j + z ˆ k
So that
Also, let the gradient fields be a function of time. Thenthe z-directed magnetic field at each point in thevolume is given by :
TT Liu, BE280A, UCSD Fall 2006
Static Gradient Fields
!
M(t) = M(0)e" j#0te
" t /T2
In a uniform magnetic field, the transverse magnetizationis given by:
In the presence of non time-varying gradients we have
!
M (r r ) = M (
r r ,0)e
" j#Bz (r r )t
e" t /T2 (
r r )
= M (r r ,0)e
" j# (B0+r
G $r r )t
e" t /T2 (
r r )
= M (r r ,0)e
" j%0te" j#
r G $
r r te" t /T2 (
r r )
![Page 5: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/5.jpg)
5
TT Liu, BE280A, UCSD Fall 2006
Time-Varying Gradient FieldsIn the presence of time-varying gradients the frequencyas a function of space and time is:
!
"r r ,t( ) = #B
z(r r ,t)
= #B0
+ #r G (t) $
r r
="0
+ %"(r r ,t)
TT Liu, BE280A, UCSD Fall 2006
PhasePhase = angle of the magnetization phasorFrequency = rate of change of angle (e.g. radians/sec)Phase = time integral of frequency
!
"#r r ,t( ) = $ "%(
r r ,& )
0
t
' d&
= $ (v
G (r r ,& ) )
r r
0
t
' d&
!
"r r ,t( ) = # $(
r r ,% )
0
t
& d%
= #$0t + '"
r r ,t( )
Where the incremental phase due to the gradients is
![Page 6: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/6.jpg)
6
TT Liu, BE280A, UCSD Fall 2006
Phase with constant gradient
!
"#r r ,t
3( ) = $ "%(r r ,& )
0
t3
' d&
!
"#r r ,t2( ) = $ "%(
r r ,& )
0
t2
' d&
= $"%(r r )t2
if "% is non - time varying.
!
"#r r ,t
1( ) = $ "%(r r ,& )
0
t1
' d&
TT Liu, BE280A, UCSD Fall 2006
Phase with time-varying gradient
![Page 7: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/7.jpg)
7
TT Liu, BE280A, UCSD Fall 2006
Time-Varying Gradient FieldsThe transverse magnetization is then given by
!
M(r r ,t) = M(
r r ,0)e
" t /T2 (r r )
e# (
r r ,t )
= M(r r ,0)e
" t /T2 (r r )
e" j$0t exp " j %$
r r ,t( )d&
o
t
'( )= M(
r r ,0)e
" t /T2 (r r )
e" j$0t exp " j(
r G (&) )
r r d&
o
t
'( )
TT Liu, BE280A, UCSD Fall 2006
Signal EquationSignal from a volume
!
sr(t) = M(r r ,t)
V" dV
= M(x,y,z,0)e# t /T2 (
r r )
e# j$0t exp # j%
r G (&) '
r r d&
o
t
"( )z"
y"
x" dxdydz
For now, consider signal from a slice along z and dropthe T2 term. Define
!
m(x,y) " M(r r ,t)
z0#$z / 2
z0 +$z / 2
% dz
!
sr(t) = m(x,y)e" j#0t exp " j$
r G (%) &
r r d%
o
t
'( )y'
x' dxdy
To obtain
![Page 8: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/8.jpg)
8
TT Liu, BE280A, UCSD Fall 2006
Signal EquationDemodulate the signal to obtain
!
s(t) = ej" 0t sr(t)
= m(x,y)exp # j$r G (% ) &
r r d%
o
t
'( )y'
x' dxdy
= m(x,y)exp # j$ Gx (%)x + Gy (%)y[ ]d%o
t
'( )y'
x' dxdy
= m(x,y)exp # j2( kx (t)x + ky (t)y( )( )y'
x' dxdy
!
kx (t) ="
2#Gx ($ )d$0
t
%
ky (t) ="
2#Gy ($ )d$0
t
%
Where
TT Liu, BE280A, UCSD Fall 2006
MR signal is Fourier Transform
!
s(t) = m(x,y)exp " j2# kx (t)x + ky (t)y( )( )y$
x$ dxdy
= M kx (t),ky (t)( )= F m(x,y)[ ]
kx (t ),ky (t )
![Page 9: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/9.jpg)
9
TT Liu, BE280A, UCSD Fall 2006
Recap• Frequency = rate of change of phase.• Higher magnetic field -> higher Larmor frequency ->
phase changes more rapidly with time.• With a constant gradient Gx, spins at different x locations
precess at different frequencies -> spins at greater x-valueschange phase more rapidly.
• With a constant gradient, distribution of phases across xlocations changes with time. (phase modulation)
• More rapid change of phase with x -> higher spatialfrequency kx
TT Liu, BE280A, UCSD Fall 2006
K-space
!
s(t) = M kx (t),ky (t)( ) = F m(x,y)[ ]kx ( t ),ky ( t )
!
kx (t) ="
2#Gx ($ )d$0
t
%
ky (t) ="
2#Gy ($ )d$0
t
%
At each point in time, the received signal is the Fouriertransform of the object
evaluated at the spatial frequencies:
Thus, the gradients control our position in k-space. Thedesign of an MRI pulse sequence requires us toefficiently cover enough of k-space to form our image.
![Page 10: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/10.jpg)
10
TT Liu, BE280A, UCSD Fall 2006
Interpretation
∆x 2∆x-∆x-2∆x 0
∆Bz(x)=Gxx
!
exp " j2#1
8$x
%
& '
(
) * x
%
& '
(
) *
!
exp " j2#2
8$x
%
& '
(
) * x
%
& '
(
) *
!
exp " j2#0
8$x
%
& '
(
) * x
%
& '
(
) *
FasterSlower
TT Liu, BE280A, UCSD Fall 2006
K-space trajectoryGx(t)
t
!
kx(t) =
"
2#G
x($ )d$
0
t
%
t1 t2
kx
ky
!
kx(t1)
!
kx(t2)
![Page 11: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/11.jpg)
11
TT Liu, BE280A, UCSD Fall 2006
K-space trajectoryGx(t)
tt1 t2
ky
!
kx(t1)
!
kx(t2)
Gy(t)
t3 t4kx
!
ky (t4 )
!
ky (t3)
TT Liu, BE280A, UCSD Fall 2006 Nishimura 1996
![Page 12: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/12.jpg)
12
TT Liu, BE280A, UCSD Fall 2006
K-space trajectoryGx(t)
tt1 t2
ky
Gy(t)
kx
TT Liu, BE280A, UCSD Fall 2006
Spin-WarpGx(t)
t1
ky
Gy(t)
kx
![Page 13: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/13.jpg)
13
TT Liu, BE280A, UCSD Fall 2006
Spin-WarpGx(t)
t1 ky
Gy(t)
kx
TT Liu, BE280A, UCSD Fall 2006
Spin-Warp Pulse Sequence
Gx(t)
ky
kx
Gy(t)
RF
![Page 14: BE280A 06 mri2 - University of California, San Diego · BE280A_06_mri2.ppt Author: Thomas Liu Created Date: 11/8/2006 4:53:51 PM](https://reader035.vdocuments.us/reader035/viewer/2022071017/5fd1467030fa1d6b98574fc1/html5/thumbnails/14.jpg)
14
TT Liu, BE280A, UCSD Fall 2006
UnitsSpatial frequencies (kx, ky) have units of 1/distance.Most commonly, 1/cm
Gradient strengths have units of (magneticfield)/distance. Most commonly G/cm or mT/m
γ/(2π) has units of Hz/G or Hz/Tesla.
!
kx(t) =
"
2#G
x($ )d$
0
t
%
= [Hz /Gauss][Gauss /cm][sec]= [1/cm]
TT Liu, BE280A, UCSD Fall 2006
ExampleGx(t) = 1 Gauss/cm
t
!
kx(t
2) =
"
2#G
x($ )d$
0
t
%= 4257Hz /G &1G /cm &0.235'10
(3s
=1 cm(1
kx
ky
!
kx(t1)
!
kx(t2)
t2 = 0.235ms
1 cm