banting & best diabetes centre...director, banting & best diabetes centre professor,...

Banting & Best Diabetes Centre

ANNUAL REPORT JULY 2012 – JUNE 2013

CONTENTS

Director’s Report ........................................................................................................................................................................ 2 Vision and Mission .................................................................................................................................................................... 3 Organizational Structure & Committees ......................................................................................................................... 3 Research Programs & Enabling Platforms Discovery Research Programs ............................................................................................................................................................ 5 Applied Research Programs ................................................................................................................................................................ 6 Enabling Platforms .............................................................................................................................................................................. 8 Membership ................................................................................................................................................................................. 9 Financial Report ....................................................................................................................................................................... 10 Funding Programs & Funding Decisions Annual Trainee Awards .................................................................................................................................................................... 11 Archie Sopman Diabetes Research and Education Awards 2012 .................................................................................................... 11 BBDC-Novo Nordisk Chair in Incretin Biology .................................................................................................................................. 12 Charles Hollenberg Summer Studentship Program 2013 ................................................................................................................ 12 Diabetes Educator of the Year Award 2012 ..................................................................................................................................... 13 Graduate Studentships: BBDC-Novo Nordisk Studentships .............................................................................................................................................. 13 BBDC-University Health Network Graduate Awards .................................................................................................................. 14 Tamarack Graduate Award in Diabetes Research ...................................................................................................................... 14 Yow Kam-Yuen Graduate Scholarship in Diabetes Research ...................................................................................................... 14 Post-doctoral Fellowships: BBDC Post-doctoral Fellowships and Hugh Sellers Post-doctoral Fellowship ............................................................................. 15 BBDC Fellowships in Diabetes Care (funded by Eli Lilly Canada) ................................................................................................ 15 Pilot and Feasibility Grants .............................................................................................................................................................. 15 Pilot Grants for Innovative Activities Related to Diabetes Education, Management, and Care ...................................................... 16 Reuben & Helene Dennis Scholar in Diabetes Research .................................................................................................................. 16 Trainee Travel Awards ..................................................................................................................................................................... 16 Educational Activities 24th Annual Scientific Day ............................................................................................................................................................... 18 BBDC Seminar Series (at City-wide Endocrine Rounds) ................................................................................................................... 20 Charles Hollenberg Summer Studentship Program: Weekly Seminar Series and Mini-conference 2013 ....................................... 20 Continuing Health Education Workshops ........................................................................................................................................ 22 Diabetes Update 2013 ..................................................................................................................................................................... 22 U of T/BBDC Diabetes and Endocrinology Update for Primary Care Practitioners ........................................................................... 25

Core Laboratory ....................................................................................................................................................................... 26 Communications ...................................................................................................................................................................... 26 Acknowledgements ................................................................................................................................................................. 27 Our Supporters ......................................................................................................................................................................... 27

BBDC ANNUAL REPORT 2012-2013 1

Director’s Report The initial phase of restructuring the BBDC and expanding its programs beyond the traditional base of discovery research into areas of applied research was completed this past year. During this process we successfully preserved all of our existing and highly valued training grants, expanding into new areas by simultaneously embarking on a renewed and invigorated fundraising drive. With the generous support of industry and philanthropic donors, we have been able to accomplish the initial phases of our 2012-2016 vision and plan. Today, the BBDC looks quite different from the BBDC of two years ago, but we are only at the beginning of a very ambitious plan to grow and expand our research capability. It goes without saying that there is a large amount of unfinished business. Keeping one eye on our vision and mission, this next year must see an increase rather than a relaxation of commitment on the part of the BBDC leadership and its members. As the inevitable disruption of the changes we have instituted begins to settle, our drive and determination to achieve even more must accelerate. We are, after all, committed to improving the lives of those living with diabetes, and the global epidemic marches on, waiting for no-one. My Director’s Report, therefore, will be more forward looking than a review of our accomplishments over the past year, which are considerable and outlined in this annual report.

What are the main issues we need to tackle in the upcoming academic year and what changes can you expect to see? One of the fundamental changes to the BBDC has been the creation of program groups, both in discovery and applied research. The purpose of this restructuring was twofold. First, to facilitate the formation of multi(trans)disciplinary groups of scientists who would work together on some of the most vexing issues in diabetes research, sharing their expertise and complementary skills with an overarching aim of translating research findings to impact patient care. Second, the formation of such groups would enable our scientists to apply for the increasing number of group grants that are becoming available, as funding agencies de-emphasise the lone principal investigator and promote the formation of transdisciplinary research teams. We have identified clusters of high impact diabetes research activities within the BBDC and have begun to assemble these program groups. The challenge over the next year or two is to strengthen the activities of these groups, to solidify their interactions and to successfully apply for and obtain group funding for the programs. A number of initiatives are underway in this respect and I believe that we can look forward to initial successes this coming year. Our newly formed Applied Research Programs are already receiving tremendous attention from a wide range of stakeholders with an interest in diabetes. The establishment of these programs is opening up a vast array of opportunities for our researchers and health care providers and for many at U of T who were already working in these areas but were not previously associated with the BBDC. The alliances, collaborations and partnerships that these programs are forming extend beyond the U of T Faculty of Medicine (for example to the Faculty of Pharmacy) and well beyond the U of T diabetes research community (for example to York University and other Canadian Universities) and promise to transform diabetes health care delivery on a national and international scale. You will be hearing much more about the expanding scope and successes of these programs during this next academic year. All of our Applied Research Programs are highly academic, with strength in knowledge generation, but the BBDC needs to do much more to enable the scaling up and implementation of the new knowledge that members of our programs generate. We are actively examining ways to do this. In summary, the BBDC is at the beginning of an exciting new phase of growth and expansion, with the overarching aim of tangibly and beneficially affecting the lives of those living with diabetes. The BBDC, however, is nothing more than the sum of the work and achievements of the highly talented and hardworking BBDC members. This is a ‘bottom up’ organization and I thank all of you for your efforts and wish you every success this upcoming year. Gary F. Lewis, MD, FRCPC Director, Banting & Best Diabetes Centre Professor, Departments of Medicine and Physiology Director, Division of Endocrinology and Metabolism Sun Life Financial Chair in Diabetes Drucker Family Chair in Diabetes Research


Vision As Canada’s leading centre of excellence for innovation in diabetes research, education, and clinical care, we will tangibly impact diabetes prevention and outcomes in Canada and globally.

Mission

We bring together researchers across multiple University of Toronto affiliated disciplines to:

Develop novel treatment paths to cure diabetes or prevent its complications

Identify innovative ways to manage diabetes and improve the lives of those living with the disease

The BBDC was established in 1978 as an Extra-Departmental Unit of the Faculty of Medicine, University of Toronto with the primary objective of advancing diabetes research, education, and care. We offer several studentships, fellowships, grants and other support for qualified individuals involved in diabetes research at the University of Toronto and its affiliated institutions. We also host educational events for researchers and diabetes healthcare providers. The programs of the BBDC are mainly supported from the income on our endowment, but we also receive generous contributions from industry and individuals which fund various research programs. PAST DIRECTORS: Dr. Daniel J. Drucker (2000-2011); Dr. Bernard Zinman (1993-2000); Dr. Charles H. Hollenberg (1981-1993); Dr. Edward A. Sellers 1978-1981, a personal friend of the co-discoverer of insulin, Dr. Charles Best)

Organizational Structure & Committees


COMMITTEES (as of June 2013) *University of Toronto

Executive Committee

DIRECTOR AND CHAIR: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology* Dr. Khosrow Adeli, Departments of Biochemistry*, and Laboratory Medicine & Pathobiology* Dr. Alison Buchan, Vice Dean, Research and International Relations, Faculty of Medicine* Dr. George Fantus, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology*; BBDC Core Laboratory Director Dr. Richard Gilbert, Department of Medicine, Division of Endocrinology & Metabolism* Dr. Tony Lam, Departments of Medicine and Physiology* Dr. Lorraine Lipscombe, Department of Medicine*, and Department of Health Policy, Management and Evaluation* Dr. Rene Wong, Department of Medicine, Division of Endocrinology & Metabolism* Dr. Minna Woo, Department of Medicine, Division of Endocrinology & Metabolism* The governance structure of the BBDC consists of a Director and Executive Committee who ensure that the goals of the Centre are appropriately implemented. The Executive Committee provides leadership and representation for the University of Toronto diabetes research and care community. Discovery Research Steering Committee

CHAIR: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology* Dr. Patricia Brubaker, Leader, Nutrients, the Digestive Tract and Diabetes Program Dr. George Fantus, Leader, Prevention and Therapy of Diabetic Complications Program Dr. Michael Farkouh, Leader, Diabetes and Heart Disease Program Dr. Denice Feig, Leader, Diabetes in Pregnancy Study Group Dr. Tony Lam, Associate Director of Research, BBDC Dr. Michael Wheeler, Leader, Islet/Stem Cell Biology Program This committee is primarily made up of the leadership of the Discovery Research Programs. Their purpose is to coordinate activities in these programs and promote collaboration between the Discovery Research and Applied Research Programs. Applied Research Steering Committee

CHAIR: Dr. Gary Lewis, Department of Medicine, Division of Endocrinology & Metabolism, and Department of Physiology* Dr. Lorraine Lipscombe, Leader, Vulnerable Populations/Population Health Program Dr. Julia Lowe, Leader, International Diabetes Outreach Program Dr. Lori MacCallum, Leader, Optimizing Care Models and Moving Knowledge into Practice Program Dr. Rene Wong, Leader, Continuing Health Education and Professional Development Program and Committee

This committee is made up of the leadership of the Applied Research Programs. Their purpose is to coordinate activities in these programs and promote collaboration between the Applied Research and Discovery Research Programs. Training and Research Excellence Committee

CHAIR: Dr. Tony Lam, Associate Director of Research, BBDC ; Departments of Medicine and Physiology* Dr. Andrew Advani, Department of Medicine, Division of Endocrinology & Metabolism* Dr. Richard Bazinet, Department of Nutritional Sciences* Dr. David Cherney, Department of Medicine, Division of Nephrology* Dr. Carolyn Cummins, Faculty of Pharmacy* Dr. Herbert Gaisano, Departments of Medicine* and Physiology* Dr. Ravi Retnakaran, Department of Medicine, Division of Endocrinology & Metabolism* Dr. Jonathan Rocheleau, Institute of Biomaterials and Biomedical Engineering* Dr. Daniel Winer, Department of Laboratory Medicine and Pathobiology* This committee (formerly known as the Research Committee) implements the scientific review of BBDC funding programs, develops the Annual Scientific Day program, and invites speakers for the BBDC Seminar Series. Continuing Health Education & Professional Development Committee

CHAIR: Dr. Rene Wong, Department of Medicine, Division of Endocrinology & Metabolism* Mrs. Leigh Caplan, Diabetes Educator, Sunnybrook Health Sciences Centre Ms. Margaret De Melo, Clinical Dietitian, Toronto Western Hospital Dr. Jeremy Gilbert, Department of Medicine, Division of Endocrinology & Metabolism* Mr. Henry Halapy, Diabetes Pharmacist, St. Michael's Hospital Dr. Lori MacCallum, Program Director, Knowledge Translation and Optimizing Care Models, Leslie Dan Faculty of Pharmacy* Dr. Phillip Segal, Department of Medicine, Division of Endocrinology & Metabolism* This committee (formerly known as the Care & Education Committee) organizes continuing health education in diabetes for the health care team and reviews applications for various BBDC funding programs.


Research Programs & Enabling Platforms

ISLET/STEM CELL BIOLOGY

Program Leader: Dr. Michael Wheeler Members: Drs. Mark Cattral, Gordon Keller, Gary Lewis, Cristina Nostro, Jonathan Rocheleau, Allen Volchuk, and Minna Woo

The Islet Centre provides a platform for researchers from a range of disciplines to study the role of the pancreatic islet cell as a key cause and target for treatment of type-1 and type-2 diabetes mellitus. The Islet Program builds upon existing infrastructure and CFI funding success of the UHN and dynamic collaborations amongst UHN scientists, including the McEwen Centre for Regenerative Medicine, to accelerate research into the prevention and treatment of this disease. The program plays a prominent role in the ability of UHN researchers to uncover molecular and physiological determinants of type 1 and type 2 diabetes and

accelerate the establishment of an unlimited source of insulin-producing pancreatic cells from stem cells that can rapidly be moved to the clinic to treat diabetes. This research program will create a centralized, multi-modal diabetes research facility at the University Health Network (UHN). NUTRIENTS, THE DIGESTIVE TRACT AND DIABETES

Program Leader: Dr. Patricia Brubaker Members: In progress

The research program brings together investigators from a wide-variety of disciplines, including endocrinology, gastroenterology, metabolism, neurobiology, nutrition and physiology. Through the application of cell, molecular and whole organism approaches, in animal models as well as in humans, researchers examine the mechanisms underlying obesity and type 2 diabetes, as well as possible nutritional and therapeutic approaches to treat these diseases. One intestinal hormone of particular interest to members of the research group is the nutrient-stimulated incretin, glucagon-like peptide-1, which has already been successfully introduced into the clinic for the treatment of type 2 diabetes and which is under

investigation for use as an anti-obesity agent. Through integration of their research expertise, and in collaboration with the CFI “3D Centre for studies on Diet, the Digestive Tract and Disease”, members of the platform will further accelerate the progression of basic science discoveries to the application of these findings in patients with obesity and diabetes. DIABETES AND HEART DISEASE

Program Leader: Dr. Michael Farkouh Members: Drs. Denice Feig, Richard Gilbert, Larry Leiter, Julie Lovshin, Muhammad Mamdani, John Parker, Bruce Perkins, Ravi Retnakaran, Jacob Udell, Diane Wherrett, and Bernard Zinman

The program connects multiple scientists and institutions from diverse disciplines/technology platforms to address the most challenging research questions in the prevention and treatment of cardiovascular complications of diabetes. This program’s main goal is to promote a Toronto-based, cross-site, clinical research collaboration on a central core platform. The initial focus will be on clinical trials in the following high impact research areas: diastolic heart failure, coronary artery disease, peripheral arterial disease, and inflammatory biomarkers/novel compounds.

DISCOVERY RESEARCH PROGRAMS The BBDC’s five Discovery Research Programs fill critical gaps in finding novel therapies to cure or treat diabetes. In bringing

together world class researchers from multiple disciplines, they are focused on taking on highly innovative, high risk research questions. They include research programs that support our strategic priorities of curing diabetes and eliminating diabetic

complications. More information on these programs can be viewed on the BBDC’s website www.bbdc.org.


http://www.bbdc.org/

PREVENTION AND THERAPY OF DIABETES COMPLICATIONS

Program Leader: Dr. George Fantus Members: Drs. Andrew Advani, David Cherney, Richard Gilbert, Andrew Paterson, Bruce Perkins, and James Scholey

This program promotes the collaborative research of investigators involved in the field of diabetes complications at the University of Toronto and its fully affiliated academic teaching hospitals and research institutes. Through monthly meetings and presentations by participating laboratories, group interactions are fostered and collaborative research granting opportunities are facilitated. The program spans cell biology animal models and human trials featuring a comprehensive and interdisciplinary research program. A major focus of the program is diabetic nephropathy (kidney disease) in which the University of Toronto has an

internationally recognized group of scientists. DIABETES IN PREGNANCY STUDY GROUP

Program Leader: Dr. Denice Feig Members: Drs. Howard Berger, Ian Blumer, Brian Cox, Jeremy Gilbert, Catherine Kelly, Shoba Kumar, Lorraine Lipscombe, Julia Lowe, Baiju Shah, Thomas Wolever, Maria Wolfs, and Afshan Zahedi

This program brings together researchers and clinicians from across the city’s academic centres in order to foster collaboration in research in the area of Diabetes in Pregnancy. The group includes epidemiologists, trialists, health services researchers, translational and basic scientists from the endocrinology and obstetrics fields. The group meets every two months to present completed or ongoing research and to discuss controversial care issues in the area of Diabetes in Pregnancy. In order to take advantage of the large population of women seen by these centres, the group is working to develop a common database so that

future research can utilize the city’s large patient population for collaborative research between sites.

OPTIMIZING CARE MODELS AND MOVING KNOWLEDGE INTO PRACTICE

Program Leader: Dr. Lori MacCallum Members: Drs. Onil Bhattacharyya, Joe Cafazzo, Michael Evans, Olavo Fernandes, Jan Hux, Michael Riddell, Michael Vallis

The mandate of this program is to ensure that scientific knowledge of what we know constitutes best practice is implemented to improve the lives of people with diabetes. Our primary focus is to identify the care gaps that could best be addressed by pharmacists and find ways to help pharmacists improve outcomes for people with diabetes. There are approximately 35,000 pharmacists in Canada, most of whom work in a community setting. People with diabetes see community pharmacists more than any other health care provider. Approximately 85% of patients are on at least one medication and pharmacists are the most likely

health care provider to identify non-adherence and provide counseling and advice on medication management. In addition, the scope of practice of pharmacists is continuing to expand from the safe procurement of medications to patient-centred care so the timing is perfect.

APPLIED RESEARCH PROGRAMS The four Applied Research Programs span the enormous chasm between the known evidence of what interventions positively impact diabetes, and what occurs in the domain of the practical. Here we bring together incredible assets that already exist in diabetes knowledge translation and population health research in order to accelerate innovations that can markedly improve

the lives of those living with diabetes. More information on these programs can be viewed on the BBDC’s website www.bbdc.org.



The Optimizing Care Models and Moving Knowledge into Practice program now has a strategic vision, a business plan, steering committees, corporate partners and an infrastructure. After several months of consulting with pharmacy chains, professional organizations, the pharmaceutical industry and individual pharmacists from across the country, we have honed in our knowledge translation strategy to community pharmacy. By developing programs that leverage and support pharmacists to provide care to people with diabetes, we can improve outcomes for these patients. This will be a multiphase approach and will include community engagement, program development, testing, dissemination and evaluation. We are currently working with a small number of pharmacies to develop and implement programs with the intention of wide-scale implementation in the future. CONTINUING HEALTH EDUCATION AND PROFESSIONAL DEVELOPMENT

Program Leader: Dr. Rene Wong Members: Mrs. Leigh Caplan, Ms. Margaret De Melo, Drs. Jeremy Gilbert, Henry Halapy, Lori MacCallum, Phillip Segal

Continuing education is a process of lifelong learning for health professionals to expand and fulfill their potential, retain their capacity to practice safely and effectively, and to meet the healthcare priorities of the population and broader health care systems. The program provides continuing health education for all members of the diabetes team – physicians, nurse practitioners, nurses, dietitians, pharmacists and other health care professionals. The BBDC bases all of its education practices on the most current, cutting-edge education research and scholarship.

VULNERABLE POPULATIONS/POPULATION HEALTH

Program Leader: Dr. Lorraine Lipscombe Members: Drs. Gillian Booth, Marisa Creatore, Denice Feig, Rick Glazer, Jan Hux, Tara Kiran, Laura Rosella, Baiju Shah

The program expands and strengthens the impact of the knowledge generated by the core group of University of Toronto-based diabetes population health scientists by bringing together front-line clinicians and public health and policy researchers to help frame research questions, and directly shape health policy. Key areas of focus are: 1) Identifying strategies to improve outcomes in socially disadvantaged populations with diabetes or at risk for diabetes; 2) Identifying priorities and building capacity for high quality research in diabetes population health; and 3) Informing changes in clinical practice and health system policies that affect

these populations in Canada. INTERNATIONAL DIABETES OUTREACH

Program Leader: Dr. Julia Lowe Members: Drs. Brian Ostrow, Gary Sibbald, Nashwah Taha

Three quarters of people with diabetes are now living in low-and middle-income countries. In the next 20 years, Africa, the Middle East, and South- East Asia will shoulder the greatest increase in diabetes prevalence. The University of Toronto, in conjunction with Canadian Association of General Surgeons and Canadian International Development Agency (CIDA), has developed a sustainable, integrated, multi-level Diabetes Education, Training, and Capacity Building model to tangibly impact the lives of those living with diabetes internationally. The Guyana Diabetic Foot Project has already resulted in a 50% reduction in diabetes related major amputations. The project uses proven U of T educational resources such as the International

Interprofessional Wound Care Course to train Guyanese key opinion leaders. In partnership with the BBDC, the Global Diabetes Collaboration Initiative plans to attract funding in order to expand these programs into the Caribbean, Sub-Saharan Africa, and the Indian subcontinent and in addition to bring effective strategies back to our own disadvantaged populations in Ontario and in Canada.


CLINICAL RESEARCH PLATFORM This platform coordinates, expands, and enhances the impact of Toronto-based clinical trial capacity across each of the priority research areas of focus for the BBDC, with an initial focus on diabetes and heart disease. The BBDC is partnering with the Applied Health Research Consortium (AHRC) at St. Michael’s Hospital to establish a Toronto-based cross-site clinical research collaboration.

INFORMATICS PLATFORM Ontario is uniquely advantaged for population health research due to its single population database which links multiple administrative and clinical datasets at ICES. However, we do not have a single dataset containing the appropriate clinical information to support population health research, clinical trial recruitment, knowledge translation research, and basic science programs. In partnership with the Applied Health Research Consortium (AHRC) at St. Michael’s Hospital, the BBDC is currently developing plans for an advanced diabetes registry, to support clinical research studies and applied research on health services and policy interventions.

CORE LABORATORY AND BIOBANKING RESOURCE The BBDC Core Laboratory provides high quality laboratory services to diabetes researchers at the University of Toronto involved in clinical and/or basic research. The lab also provides services to the wider scientific community including external academic and/or industry initiated research. The BBDC is expanding its Core Laboratory services to better serve the needs of BBDC researchers and affiliates as the BBDC expands its research enterprise. A steering committee of BBDC members based at Mount Sinai Hospital, The Hospital for Sick Children, and St. Michael’s Hospital have established close collaborations across institutions in order to offer a more complete lab inventory that will greatly support diabetes researchers. Assays and services that go beyond the traditional services of the BBDC core lab will be made available to investigators and an effort to enhance biobanking is underway.

TRAINING AND RESEARCH EXCELLENCE PLATFORM The BBDC is an extraordinary training ground for the diabetes researchers and innovators of the future, offering multiple levels of support for qualified individuals involved in diabetes research, patient care, and education. The current core offering of the BBDC is its broad portfolio of training grants offered to students, postdoctoral fellows, and investigators across a diverse set of disciplines in the University of Toronto and Toronto Academic Health Sciences Network (TAHSN). We will maintain this incredible training program, but will incorporate feedback from the field on how to enhance the program for better impact, community building, and profile-building for the BBDC.

ENABLING PLATFORMS Underpinning the Discovery and Applied research programs are technology and other support platforms that draw upon a

broad set of assets within the University of Toronto research community. These platforms will enable the research programs, allowing for maximal potential for impact. More information on these platforms can be viewed on the BBDC’s website

www.bbdc.org.



Membership The BBDC membership is a network of individuals involved in diabetes research, education and care from various departments at the University of Toronto and its affiliated hospitals. Membership is free and open to individuals involved in full or part-time diabetes research, education, or patient care (i.e. scientists, physicians, nurses, dietitians, pharmacists, etc.) and whose primary university appointment or employment (i.e. more than 50% of total salary), is with the University of Toronto or one of its affiliated hospitals listed below. The BBDC occasionally makes membership available to non-U of T affiliated faculty and health professionals who are invited by the BBDC to play a major role in the Centre’s activities (e.g. those asked to join BBDC committees or to participate in research programs). Post-doctoral fellows, graduate students, undergraduate students, research associates and technicians are not eligible for membership; however, they are welcome to join our e-mail list. Fully Affiliated Hospitals Community Affiliated Hospitals and Sites

• Baycrest • Centre for Addiction and Mental Health • Holland Bloorview Kids Rehabilitation Hospital • Hospital for Sick Children • Mount Sinai Hospital • St. Michael's Hospital • Sunnybrook Health Sciences Centre • University Health Network (includes Princess Margaret

Hospital, Toronto General Hospital, Toronto Western Hospital, and Toronto Rehabilitation Institute)

• Women's College Hospital

• Bridgepoint Health • Credit Valley Hospital • George Hull Centre for Children and Families • Hincks-Dellcrest Centre • Humber River Regional Hospital • Lakeridge Health Network • Markham-Stouffville Hospital • North York General Hospital • Ontario Shores Centre for Mental Health Sciences • Providence Healthcare • The Royal Victoria Hospital • Scarborough Hospital • St. John's Rehabilitation Hospital • St. Joseph's Health Centre • Southlake Regional Health Centre • Surrey Place Centre • Toronto East General Hospital • Trillium Health Centre • West Park Healthcare Centre

A total of 165 members are registered with the BBDC: 100 are U of T faculty involved in diabetes research and 65 are health professionals involved in diabetes care or education. All members are profiled on our website www.bbdc.org. BENEFITS OF MEMBERSHIP

Membership allows individuals to become eligible to apply for the Centre's funding programs. (Specific eligibility requirements are outlined for each funding program.)

Each research member's diabetes-related activities and contact information are posted on our website which enables local and foreign trainees to locate potential supervisors at the University, and helps facilitate the development of collaborative diabetes-related activities.

Membership enables individuals to attend the BBDC's Annual Scientific Day and other events which may be open to

members and their trainees only.



Financial Report Statement of operations for the year ended June 30, 2013

2012-2013 REVENUES Unrestricted: Endowment income1 473,205 Donations, unrestricted educational grants, miscellaneous 31,835 Restricted: University Health Network-BBDC partnership (partially funded by Toronto General & Western Hospital Foundation) 230,000 BBDC-Novo Nordisk Studentship endowment fund (OSOTF)2 199,532 Tamarack Graduate Award endowment fund (OSOTF)2 25,843 Yow Kam-Yuen Scholarship endowment fund (OSOTF)2 18,811 BBDC-Novo Nordisk Chair in Incretin Biology endowment fund 187,194 Eli Lilly fund for Fellowships in Diabetes Care 120,000 Sun Life Financial Professorship fund (Toronto General & Western Hospital Foundation) 100,000 Diabetes Innovation Fund (Toronto General & Western Hospital Foundation) 55,400 Knowledge Translation fund 23,110 Archie Sopman endowment fund (Toronto General & Western Hospital Foundation)3 30,216 TOTAL REVENUES 1,495,146 EXPENDITURES Administration: Salaries and benefits 363,709 Office supplies/miscellaneous/review expenditures 23,559 Educational Functions: BBDC Seminar Series 8,556 Annual Scientific Day 32,114 Continuing Health Education Workshop 0 Optimizing Care Models and Moving Knowledge into Practice Program 23,110 Funding Programs for Trainees: Hugh Sellers Fellowship; BBDC Post-doctoral Fellowships; Fellowships in Diabetes Care (funded by Eli Lilly) 230,814 BBDC-Novo Nordisk Studentships (OSOTF)2 174,101 BBDC-University Health Network Graduate Awards 51,707 Tamarack Graduate Award in Diabetes Research (OSOTF)2 21,000 Yow Kam-Yuen Graduate Scholarship in Diabetes Research (OSOTF)2 18,800 Charles Hollenberg Summer Studentship Program 2013 36,000 Trainee Travel Awards 28,978 Annual Trainee Awards 1,557 Funding Programs and Support for Faculty & Health Care Professionals: Reuben & Helene Dennis Scholar in Diabetes Research 10,000 Pilot and Feasibility Grants (biennial program) 0 Pilot Grants for Innovative Activities Related to Diabetes Education, Management & Care 20,000 Archie Sopman Diabetes Research and Education Awards 20123 6,795 BBDC-Novo Nordisk Chair in Incretin Biology 187,194 Diabetes Educator of the Year Award 2012 1,000 TOTAL EXPENDITURES 1,238,994 REVENUES LESS EXPENDITURES 256,152

NOTES TO FINANCIAL STATEMENT: 1 Endowment income represents investment income distributed by the University's Long-Term Capital Appreciation Pool. Market conditions can affect future

income distribution. 2 Ontario Student Opportunity Trust Fund (OSOTF). Revenue amount includes carry forward of unspent endowment income from previous year. Payments made directly to award recipients by Faculty of Medicine Graduate and Life Sciences Education. 3 This endowment is held at the University Health Network. Revenue amount includes carry forward of unspent endowment income from previous year. Payments

are made directly to the award recipients by the Toronto General & Western Hospital Foundation.


Funding Programs & Funding Decisions ELIGIBILITY: The majority of the BBDC's funding programs are open to members of the BBDC. Specific eligibility requirements are outlined for each program.

ANNUAL TRAINEE AWARDS Each year graduate, undergraduate, and medical students, post-doctoral and clinical fellows and medical residents are invited to submit their abstract for the Annual Trainee Awards competition. To be eligible, the trainee’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. The abstract must be directly related to diabetes and the trainee must be first author. The best 10 abstracts are selected by the Training and Research Excellence Committee for poster presentation at the BBDC Annual Scientific Day. The 2012/2013 posters were co-judged and prize winners selected by Dr. Randy Levinson, Senior Editor of Nature Medicine and Dr. Herbert Gaisano, Professor, Departments of Medicine and Physiology, University of Toronto. The winners receive gift cards for the University of Toronto Bookstore. The 2012/2013 prize winners are:

Award Recipient Supervisor(s) Abstract Title

1st Prize: $400 gift card Brittany Rasmussen Dr. Tony Lam

Leptin activates a jejunal PI3K-dependent and STAT3-independent signaling pathway to lower glucose production in uncontrolled diabetes

2nd Prize: $300 gift card Sally Yu Shi Dr. Minna Woo Absence of the ROS scavenger DJ-1 paradoxically

protects mice from obesity and insulin resistance

3rd Prize: $200 gift card Erica Cai Dr. Minna Woo Rb in Pancreatic Progenitors Controls α- and β-cell

Fate

Honourable Mention: $100 gift card

Wilfred Ip Dr. Tianru Jin GLP-1-derived nonapeptide GLP-1(28-36)amide represses hepatic gluconeogenesis and improves pyruvate tolerance in high fat diet fed mice


Charlotte Dong Dr. Patricia Brubaker Role of the intestinal epithelial insulin-like growth factor-1 receptor in glucagon-like peptide-2-mediated decrease in gut permeability


Caroline Kaercher Kraemer

Dr. Ravi Retnakaran and Dr. Bernard Zinman

Determinants of Reversibility of Beta-cell Dysfunction in response to Short-term Intensive Insulin Therapy in Patients with Early Type 2 Diabetes

ARCHIE SOPMAN DIABETES RESEARCH AND EDUCATION AWARDS 2012 This award is only open to University Health Network employees (i.e. employees of Toronto General Hospital, Toronto Western Hospital, or Princess Margaret Hospital). To be eligible, the applicant(s) must be a dietitian, nurse, social worker, pharmacist, staff physician or scientist who is primarily involved in diabetes research, education, or clinical care. The principal applicant must also be a member of the BBDC. Funding can be used for: 1) Travel to a national or international diabetes meeting, or 2) To support a visiting lecturer in diabetes or metabolic disorders. Applications are reviewed by the BBDC’s Director. Funding for this program is provided by the Toronto General and Western Hospital Foundation Archie Sopman endowment fund. The endowment is held at the University Health Network (UHN) and award payments are made directly to the recipients by the UHN. The funding recipients for the 2012 calendar year are:

Recipient Position and UHN Site Purpose Award Joyce Chan Clinical Pharmacist, Toronto General Hospital Travel to diabetes meeting Up to $1,000 Lucia Chan Registered Nurse, Toronto Western Hospital Travel to diabetes meeting Up to $1,000

Margaret De Melo Practice Leader, Clinical Nutrition, Toronto Western Hospital Travel to diabetes meeting Up to $800


Doreen Klar Clinical Dietitian, Allied Health, Toronto Western Hospital Travel to diabetes meeting Up to $612

Louisa Li Clinical Dietitian, Cardiology, Toronto General Hospital Travel to diabetes meeting Up to $1,000

Kitty Mak Nurse Clinician, Diabetes, Toronto General Hospital Travel to diabetes meeting Up to $1,000

Artee Srivastava Nurse Practitioner, Toronto General Hospital Travel to diabetes meeting Up to $1,00 Mary T. Weiland Clinical Dietitian, Toronto Western Hospital Travel to diabetes meeting Up to $680

BBDC - NOVO NORDISK CHAIR IN INCRETIN BIOLOGY In 2010, the BBDC-Novo Nordisk Chair in Incretin Biology was established at the Banting & Best Diabetes Centre, University of Toronto. The research Chair was made possible through a $3 million gift from Novo Nordisk in appreciation of the innovative diabetes research undertaken by the Centre. Both Novo Nordisk and the University of Toronto, Faculty of Medicine have a long-standing tradition of diabetes research originally dating back to the discovery of insulin, and most recently focused on the science of incretin biology. Dr. Daniel J. Drucker is the inaugural BBDC-Novo Nordisk Chair in Incretin Biology from May 2010 to April 2015. CHARLES HOLLENBERG SUMMER STUDENTSHIP PROGRAM 2013 This program is designed to introduce young undergraduate and medical students to the field of diabetes research. Each year the BBDC awards up to 15 studentships valued at $4,800 each to qualified undergraduate and/or medical students to carry out full-time summer research in diabetes. To be eligible, the student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. The student’s stipend is paid equally by the BBDC and the supervisor. Students are required to participate in the program’s weekly Seminar Series and to present their work at the end of the summer in a workshop format at the Mini-conference (see page 21 for seminar series and conference program). Applications are reviewed by members of the Training and Research Excellence Committee. The following are the 2013 summer studentship recipients:

Recipient Supervisor(s) Title of Research Noah Hahn Dr. Andrew Advani Endothelial dysfunction and albuminuria in diabetes

Louisa Ho Dr. Michael B. Wheeler Characterizing the physiological role of novel zinc influx transporters in the pancreatic β cell

Deborah Koh Dr. Richard E. Gilbert Secretory factors of early-outgrowth cells as novel treatment for diabetic nephropathy

Johnathan Lau Dr. I. George Fantus The role of TxNip in the development of diabetic neuropathy

Yujin (Emily) Li Dr. Amira Klip The role of saturated fats in altering the integrity of muscle microvasculature

John Liu Dr. Andras Nagy and Dr. Kristina Nagy

In vitro and in vivo reprogramming of pancreatic beta cells and establishment of a novel stem-cell based therapy for type 1 diabetes

Catherine Lu Dr. James Scholey Role of RGS5 in High Glucose-induced Kidney Cell Hypertrophy Alyssa Molinaro Dr. Derek van der Kooy Pancreatic stem cells from the guy: a new treatment for diabetes

Daanish Mulla Dr. Greg Wells The Pathophysiology of Exercise Intolerance in Children Post-Bone Marrow Transplant – Early Indicators of Metabolic Syndrome and Type 2 Diabetes

Chin Ting (Chris) Shyi Dr. Shirley X.Y. Wu Evaluation of New Glucose-Responsive Insulin Delivery Device In Vitro and In Vivo

Yimeng (Suzanne) Wang Dr. Qinghua Wang Are the trophic effects of GABA diminished in vivo in diabetic mouse models due to defects in GABA and GABAAR expression?

Justin Wong Dr. Farid H. Mahmud Evaluation of Baseline Characteristics of Diabetes Population Screened for Celiac Disease: Gastrointestinal Symptoms and Serology


Wei (Kelly) Wu Dr. Patricia Brubaker Circadian release of glucagon-like peptide-1 (GLP-1): in vitro and in vivo studies

Wenqing (Wendy) Ye Dr. Denise D. Belsham Insulin Signaling in the Hypothalamus: Effects of Insulin Resistance

Roman Zyla Dr. Warren Lee Transcytosis of insulin across the microvascular endothelium – implications for insulin resistance

DIABETES EDUCATOR OF THE YEAR AWARD 2012 This award recognizes diabetes educators who have demonstrated outstanding efforts and achievements in their role as a diabetes educator. One award is presented each year. Candidates must be nominated for the award by a health care professional. To be eligible for nomination, the candidate must be a full or part-time diabetes educator or other health care professional employed by a University of Toronto-affiliated institution. Nominations are reviewed by members of the Continuing Health Education & Professional Development Committee. The 2012 award recipient is:

Recipient Profession and Hospital Affiliation Award

Leigh Caplan, RN, BSc, MA CDE Diabetes Educator, Sunnybrook Health Sciences Centre $1,000

GRADUATE STUDENTSHIPS BBDC-Novo Nordisk Studentships

A collaboration with Novo Nordisk Canada Inc. was established in 1996 to provide long term endowment in support of graduate students who are pursuing a career in diabetes research. As part of the Ontario Student Opportunity Trust Fund program (OSOTF), the support obtained from Novo Nordisk was matched by equal contributions from the University of Toronto and the Government of Ontario for a total endowment of 4.2 million dollars. To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto. The student must demonstrate financial need, and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Applications are reviewed by the Training and Research Excellence Committee. Studentships are valued at up to $21,000 each. The following are the 2012/2013 award recipients:

Recipient Supervisor(s) Title of Research Mona Abraham Dr. Tony Lam Insulin action in the Dorsal Vagal Complex Jara Brunt Dr. Minna Woo The role of HIF-2a in pancreatic beta-cells

Laura Finkelberg Dr. Carol Westall Structural and functional changes to cone photoreceptors in adolescents with type 1 diabetes

Alexender Ivovic Dr. Adria Giacca The roles of IKKβ and ‘β-cell insulin resistance’ in fat-induced β-cell dysfunction

Samantha Li Dr. Patricia Brubaker Role of the SNARE Proteins in Glucagon-like Peptide-1 Exocytosis

Lemieux Luu Dr. Michael Wheeler Acute Deletion of SirT1 in Pancreatic Beta Cells Causes Impaired Insulin Secretion in Mice

Jonathan Menchella Dr. Denise Belsham The role of AMPK in alleviating cellular insulin resistance in immortalized rHypoE-19 hypothalamic neurons

Tanya Odisho Dr. Allen Volchuk and Dr. Adria Giacca

ER stress in Pancreatic β-cells: 1. Function of ATF6β in ER Stress Response; 2. Role in Hyperglycemia-Induced β-cell Dysfunction

Anu Shah Dr. George Fantus and Dr. Susan Quaggin

The Role of Thioredoxin Interacting Protein (TXNIP) in the Development of Diabetic Nephropathy

Pamuditha Silva Dr. Jonathan Rocheleau and Dr. Dawn Kilkenny

Investigating the mechanisms and dynamics of fibroblast growth factor receptor like 1 (FGFRL1) in pancreatic β-cells through quantitative fluorescence microscopy

Tharini (Tara) Sivasubramaniyam Dr. Minna Woo Dissecting the contribution of hepatic insulin resistance versus

inflammation in atherosclerosis.


BBDC-University Health Network Graduate Awards

This graduate award was made possible by the 10-year partnership between the BBDC and the University Health Network. To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. The student’s supervisor must also hold a full-time UHN appointment as an active staff physician, or if he/she holds an associate staff position or staff scientist position the supervisor's principal laboratory or clinical research space must be physically located at the UHN. Applications are reviewed by the Training and Research Excellence Committee. Awards are valued at up to $21,000 each. The following are the 2012/2013 award recipients:

Recipient Supervisor(s) Title of Research

Ronnie Har Dr. David Cherney The use of Novel Urinary Biomarkers for Early Identification of Patients at Risk for Early Cardio-Renal Disease in Patients With Type 1 Diabetes

Xinyi Huang Dr. Michael Wheeler Identification and Characterization of Novel Protein Interactions for GLP-1R

Wilfred Ip Dr. Tianru Jin The role of the WNT signaling pathway and type 2 diabetes risk gene, transcription factor 7-like 2 (TCF7L2), in hepatic glucose production

Brittany Rasmussen Dr. Tony Lam Dissecting Duodenal Nutrient Sensing Mechanisms and the Regulation of Glucose Production

Tamarack Graduate Award in Diabetes Research

This graduate scholarship was made possible by a generous private endowment which was matched by equal funding from the University of Toronto and the Government of Ontario under the Ontario Student Opportunity Trust Fund program (OSOTF). To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto. The student must demonstrate financial need, and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Applications are reviewed by the Training and Research Excellence Committee and preference is given to those students whose primary area of study is vascular problems of diabetes. The award is valued at up to $21,000. The 2012/2013 award recipient is:


Evan Lewis Dr. Thomas Wolever and Dr. Greg Wells

The effect of omega-3 fatty acid supplementation for Type 2 diabetic sensorimotor polyneuropathy: The use of an essential nutrient to stop disease progression

Yow Kam-Yuen Graduate Scholarship in Diabetes Research

This graduate scholarship was made possible by a generous private endowment which was matched by equal funding from the University of Toronto and the Government of Ontario under the Ontario Student Opportunity Trust Fund program (OSOTF). To be eligible for this award, applicants must be registered with the Faculty of Medicine, School of Graduate Studies at the University of Toronto. The student must demonstrate financial need, and must be carrying out studies in diabetes research. The student’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Applications are reviewed by the Training and Research Excellence Committee. The value of the award varies depending on endowment income and is normally between $10,000 and $15,000. The 2012/2013 award recipients are:


Charlotte Xiaoman Dong Dr. Patricia Brubaker Role of the renal insulin-like growth factor-1 receptor in altered glucose reabsorption in diabetes

Jennifer Sacco Dr. Khosrow Adeli The Role of GLP-1 Receptor Signalling in regulation of Hepatic Triglyceride Homeostasis and VLDL Production in Insulin Resistance


POST-DOCTORAL FELLOWSHIPS BBDC Post-doctoral Fellowships and Hugh Sellers Post-doctoral Fellowship

The support of research fellows has been a major priority of the BBDC since the Centre’s inception. Each year, the BBDC endeavours to provide as many fellowships as possible including one Hugh Sellers Post-doctoral Fellowship. The program provides one year of funding for an individual holding an M.D. or Ph.D. who is carrying out full-time diabetes research training at the University of Toronto or one of its fully affiliated institutions. The fellow’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Stipends are normally $40,000 or $50,000. Applications are reviewed by members of the Training and Research Excellence Committee. The following are the 2012/2013 recipients:

Award Recipient Supervisor(s) Title of Research BBDC Post-doctoral Fellowship Dr. Satya Dash Dr. Gary Lewis Regulation of intestinal and hepatic lipoprotein

metabolism by resveratrol BBDC Post-doctoral Fellowship Dr. Jessica Yue Dr. Tony Lam CNS glucagon signaling and the regulation of

hepatic triglyceride-rich lipoprotein secretion BBDC Post-doctoral Fellowship Dr. Ming Zhang Dr. Michael Wheeler Discovery of novel Glucagon like peptide-1

receptor interacting proteins Hugh Sellers Post-doctoral Fellowship Dr. Nicolas Pillon Dr. Amira Klip The crosstalk between muscle and immune cells

BBDC Fellowships in Diabetes Care (Funded by Eli Lilly Canada)

The BBDC Fellowships in Diabetes Care have been made possible by a generous $580,000 contribution over 5 years from Eli Lilly Canada. This program provides one year of funding for an individual holding an M.D. or Ph.D. who is carrying out full-time diabetes research training at the University of Toronto or one of its fully affiliated institutions. The fellow’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a member of the BBDC. Stipends are normally $40,000 or $50,000 for one year. Applications are reviewed by members of the Training and Research Excellence Committee. The following are the 2012/2013 recipients:


Dr. Hari Kosanam Dr. Richard Gilbert and Dr. Eleftherios Diamandis

Deciphering Sirtuin1-dependent Kidney Lysine Acetylome in Diabetes: Identification of Plausible Therapeutic Targets and Biomarkers of Diabetic Nephropathy

Dr. Christine Lee (September 2012 to January 2013)

Dr. Anthony Hanley Plasma non-esterified fatty acids and the progression of insulin resistance and pancreatic beta-cell dysfunction in individuals at high risk of developing diabetes

Dr. Indri Purwana Dr. Qinghua Wang Study of the autocrine regulatory mechanism of the signaling target of gamma aminobutyric acid (GABA) in pancreatic islet beta-cells

PILOT AND FEASIBILITY GRANTS (Biennial Program) This program provides funding of up to $30,000 per applicant, for one year, to enable eligible investigators to explore completely new initiatives in the area of diabetes research. The competition is open to both new and established full-time faculty members of the University of Toronto. The principal applicant must be a full-time faculty member of the University of Toronto and must also be a member of the BBDC. Applications are reviewed by members of the Training and Research Excellence Committee as well as external reviewers. This funding program is normally offered once every two years. There was no competition held in 2012/2013.


PILOT GRANTS FOR INNOVATIVE ACTIVITIES RELATED TO DIABETES EDUCATION,

MANAGEMENT & CARE This program provides funding of up to $20,000 for pilot projects which are one to two years in length. Funding is intended to support new research initiatives in the following general areas: 1) Diabetes care delivery; 2) Evaluation of diabetes education programs; and 3) Practical issues in diabetes management. It is designed to encourage new academic research activities from individuals not usually supported by traditional granting processes, specifically, front line health care professionals working at the University of Toronto-affiliated hospitals or working with U of T-affiliated academics. Applications are reviewed by the Continuing Health Education and Professional Development Committee. The following is the 2012/2013 award recipient:

Recipient Title of Research Award Dr. Lorraine Lipscombe and Dr. Denice Feig Dr. Julia Lowe Dr. Paula Harvey Prof. Marilyn Evans

Diabetes Prevention Plan for New Mothers with Recent Gestational Diabetes Mellitus: Pilot & Feasibility Study $20,000

REUBEN & HELENE DENNIS SCHOLAR IN DIABETES RESEARCH (Biennial Program) This award which was established to support new University of Toronto diabetes research faculty, provides $10,000 per year for two years. To be eligible, the applicant must be involved in diabetes research and must be a principal investigator who holds a full-time academic appointment with the University of Toronto. Faculty are eligible for this funding normally within five years of their first faculty appointment. Applications are reviewed and ranked by members of the Training and Research Excellence Committee as well as an external reviewer(s). The following is the 2012-2014 award recipient:

Recipient Title of Research Award

Dr. Andrew Advani Histone modification in diabetic nephropathy $10,000 for 2012/2013 $10,000 for 2013/2014

TRAINEE TRAVEL AWARDS The Trainee Travel Awards are available to U of T graduate students, undergraduate students, medical students, post-doctoral fellows, medical residents and clinical fellows conducting diabetes research. Trainees receive reimbursement of up to $1,000 (CAD) to attend a national or international meeting. To be eligible, the trainee must be presenting a first-author abstract directly related to diabetes research which has been accepted for poster or oral presentation at the meeting. The trainee’s supervisor must be a University of Toronto faculty member and a BBDC member. Applications are reviewed by members of the Training and Research Excellence Committee. The 2012/2013 award recipients are:

Period 1 Recipients (For travel occurring between July 1 and December 31, 2012): Recipient Supervisor(s) Abstract Title

Erica Pei-Shan Cai Dr. Minna Woo The role of Rb and its family protein p107 in regulating cell cycle of pancreatic β- and α-Cells

Sarah Farr Dr. Khosrow Adeli Glucagon-like peptide-1 (GLP-1) limits intestinal lipid availability and modulates gut lipoprotein metabolism

S. Mohsen Hosseini Dr. Andrew Paterson Genome-wide association study of time-to diabetic retinopathy

Negar Karimian Dr. Herbert Gaisano and Dr. Mladen Vranic

Selective Somatostatin Receptor Type 2 Antagonism Prevents Hypoglycaemia In Type 1 Diabetic BB Rats

Christine Lee Dr. Anthony Hanley Components of metabolic Syndrome and the Longitudinal Progression of Insulin Clearance – the Insulin Resistance Atherosclerosis Study (IRAS)

Iliana Lega Dr. Lorraine Lipscombe The Association of Metformin Therapy and Mortality Following Breast Cancer: an Illustration of Immortal Time Bias


Cynthia T. Luk Dr. Minna Woo Essential role of adipocyte focal adhesion kinase in mediating insulin resistance

Steve Orlov Dr. Bruce Perkins Heart rate variability predicts future advanced chronic kidney disease in type 1 diabetes

Natasha Park Dr. Rohan Ganguli Eating Behavior in Individuals with Psychotic Illnesses

Jennifer Sacco Dr. Khosrow Adeli The Role of GLP-1 Receptor Signaling in Regulation of Hepatic Triglyceride Homeostasis and VLDL Production

Alanna Weisman Dr. Bruce Perkins Identification and Prediction of Diabetic Sensorimotor Polyneuropathy Using Individual and Simple Combinations of Nerve Conduction Study Parameters

Period 2 Recipients (For travel occurring between January 1 and June 30, 2013) Recipient Supervisor(s) Abstract Title(s)

Mona Abraham Dr. Tony Lam Central Administration of Glucagon Activates Glucagon Receptors to Inhibit Glucose Production in Mice In Vivo

Tim Chiu Dr. Amira Klip Rac-1 superactivation elicits insulin-independent GLUT4 translocation that bypasses signalling defects imposed by JNK- and ceramide-induced insulin resistance

Sheila Costford Dr. Amira Klip Differential Effects of Saturated and Unsaturated Fatty Acids on Macrophage-Muscle Cell Crosstalk in Metabolic Inflammation

Robert Goldberg Dr. Ravi Retnakaran Predictors and Clinical Implications of a False Negative Glucose Challenge Test in Pregnancy

Ronnie Har Dr. David Cherney The Effects of Renal Hyperfiltration on Urinary Inflammatory Cyokines/Chemokines in Patients with Uncomplicated Type 1 Diabetes Mellitus

Alexander Ivovic Dr. Adria Giacca Genetic Deletion of IKKβ in β-Cells Prevents Fat-Induced β-Cell Dysfunction In Vivo

Luke W. Johnston Dr. Anthony Hanley The association of leg length with metabolic abnormalities underlying type 2 diabetes mellitus: the PROMISE cohort

Lilia Magomedova Dr. Carolyn Cummins Arginine and glutamate rich 1 is a novel glucocorticoid receptor involved in gluconeogenesis

Geetha Murkerji Dr. Lorraine Lipscombe Perceived risk of diabetes with gestational diabetes

Tanya Odisho Dr. Allen Volchuk ATF6β Depletion Increases Susceptibility of Pancreatic β-Cells to Endoplasmic Reticulum Stress-Induced Apoptosis

Rucha Patel Dr. Carolyn Cummins Molecular crosstalk between FR and hepatic liver x receptor β (LXRβ) in glucocorticoid induced hyperglycemia

Nicolas Pillon Dr. Amira Klip Palmitate-challenged muscle cells become inflamed and cause macrophage inflammatory polarization

Krishana Sankar Dr. Jonathan Rocheleau Determining the Effect of a Hypoxia Mimetic and Microfluidic Flow on Islet Vasculature and Function

Sally Yu Shi Dr. Minna Woo Absence of the ROS scavenger DJ-1 paradoxically protects mice from obesity and insulin resistance

Meghan Sauve Dr. Steffen-Sebastian Bolz The tumor necrosis factor alpha/sphingosine-1-phosphate signalling axis mediates augmentation of microvascular tone in a mouse model of type 2 diabetes mellitus

Ferhan Siddiqi Dr. Andrew Advani Histone methyltransferase inhibition accelerates renal injury in experimental diabetes

Wen Qin Yu Dr. Adria Giacca p38 MAPK Mediates Hepatic Insulin Resistance Induced by Prolonged Exposure to Free Fatty Acids In Vivo

Jessica Yue Dr. Tony Lam Glycine sensing in the dorsal vagal complex lowers food intake

Dan Zhu Dr. Herbert Gaisano Syntaxin 2 Acts as Inhibitory SNARE for Newcomer Insulin Granule Exocytosis


EDUCATIONAL ACTIVITIES 24TH ANNUAL SCIENTIFIC DAY This annual event which is planned by the Training and Research Excellence Committee provides an opportunity for BBDC members to exchange scientific information and ideas, and assists in the development of collaborative diabetes-related research activities. It also provides a valuable opportunity for BBDC trainees to network and present their research. BBDC post-doctoral fellowship recipients, graduate studentship recipients and select Annual Trainee Awards abstract submitters present posters of their work. The event focuses on the latest diabetes research topics with both clinical and laboratory applications. In addition, the Director has an opportunity to review the activities of the Centre over the past year with the Centre membership at large. This event is open and free to all BBDC members, their trainees and U of T endocrine residents. We gratefully acknowledge partial support of this year’s event by: Boehringer Ingelheim/Eli Lilly Diabetes Alliance, Merck Canada Inc., Novo Nordisk, Pfizer, Sanofi Diabetes, Takeda, and the University Health Network. The program is as follows:

24TH Annual Scientific Day Friday, May 10, 2013

The Old Mill Inn, 21 Old Mill Road, Toronto

8:00 - 8:40 AM Continental breakfast and poster set-up

SESSION 1 Chair: Dr. David Cherney

8:40 - 8:45 Welcome and Introduction: Dr. Tony Lam

8:45 - 9:15 The Identification of Diabetic Neuropathy in Type 1 Diabetes Dr. Bruce A. Perkins

9:15 - 9:45 Steno, eNOS and the Link Between Albuminuria and Cardiovascular Disease in Diabetes Dr. Andrew Advani Recipient: BBDC’s Reuben & Helene Dennis Scholar 2012-2014

9:45 - 10:00

Regulation of Intestinal and Hepatic Lipoprotein Metabolism by GLP-2 Dr. Satya Dash BBDC Post-doctoral Fellowship recipient 2012/2013 (Supervisor: Dr. Gary Lewis)

10:00 - 11:15 Refreshments, Poster Presentations, and BBDC Annual Trainee Awards Competition poster judging by Drs. Randy Levinson and Herbert Gaisano. Moderator: Dr. Tony Lam

SESSION 2 Chair: Dr. Jonathan Rocheleau

11:15 - 11:45 Inflammation and Insulin Resistance - The Muscle Is No Longer a Bystander Dr. Amira Klip

11:45 - 12:15 PM Generating Beta Cells from Human Pluripotent Stem Cells Dr. M. Cristina Nostro

12:15 - 12:45

BBDC Director’s Report: Dr. Gary Lewis Professor, Department of Medicine, Division of Endocrinology & Metabolism, University of Toronto

12:45 - 1:45 Lunch

CHARLES HOLLENBERG MEMORIAL LECTURESHIP Chair: Dr. Carolyn Cummins

1:45 - 2:45 Regulation of Nutrient Metabolism by FGF21 Dr. David Mangelsdorf

2:45 - 2:55 BBDC Annual Trainee Awards Presentation 2012/2013 Drs. Randy Levinson, Herbert Gaisano and Tony Lam

2:55 Evaluation and adjournment


GUEST SPEAKER

David J. Mangelsdorf, PhD Professor and Chair, Department of Pharmacology Investigator, Howard Hughes Medical Institute Raymond and Ellen Willie Distinguished Chair in Molecular Neuropharmacology Distinguished Chair in Pharmacology University of Texas Southwestern Medical Center

LOCAL SPEAKERS *University of Toronto

Andrew Advani, BSc, MBChB(Hons), FRCP(UK), PhD Assistant Professor, Department of Medicine, Division of Endocrinology and Metabolism* BBDC Reuben & Helene Dennis Scholar recipient 2012-2014 Amira Klip, PhD Canada Research Chair in Cell Biology of Insulin Action Professor, Departments of Paediatrics, Biochemistry, and Physiology* Senior Scientist, The Hospital For Sick Children M. Cristina Nostro, PhD Harry Rosen Chair in Diabetes and Regenerative Medicine Research McEwen Centre for Regenerative Medicine Scientist, Toronto General Research Institute

Bruce A. Perkins, MD, MPH, FRCPC Associate Professor, Department of Medicine, Division of Endocrinology and Metabolism* Clinician Scientist, Mount Sinai Hospital Satya Dash, MD, PhD BBDC Post-doctoral Fellowship recipient 2012/2013 Supervisor: Dr. Gary Lewis POSTER JUDGES

Randy Levinson, PhD Senior Editor, Nature Medicine Herbert Gaisano, MD, FRCPC, FACP Professor, Departments of Medicine and Physiology*

24th Annual Scientific Day poster presentations 24th Annual Scientific Day speaker, Dr. Cristina Nostro


BBDC SEMINAR SERIES (at City-wide Endocrine Rounds) Each year the BBDC invites guest lecturers to present their work on diabetes research at our Seminar Series. To ensure a broad audience, seminars have been incorporated into the University of Toronto City-wide Endocrine Rounds which are held every Friday morning at 8 a.m. at the Mount Sinai Hospital. This year’s presentations are as follows:

BBDC Seminar Series 2012/2013 In conjunction with City-wide Endocrine Rounds

8:00 – 9:00 a.m. Mount Sinai Hospital, Lebovic Building

60 Murray Street, 3rd Floor Conference Room

October 26, 2012 New Developments in the Pathogenesis of Fatty Liver Disease Jay D. Horton, MD Dr. Robert C. and Veronica Atkins Chair in Obesity & Diabetes Research Professor, Internal Medicine, Molecular Genetics UT Southwestern Medical Center

November 2, 2012 To Burn or to Store: The Quality of Fat and Energy Homeostasis Stephan Herzig, MD Professor and Division Head, Joint Research Division Molecular Metabolic Control German Cancer Research Center (DKFZ) Heidelberg Center for Molecular Biology (ZMBH) University of Heidelberg Heidelberg University Hospital (Co-hosted by the BBDC and the Faculty of Pharmacy)

February 22, 2013 A Novel Pathway Regulating SREBP-1c and De Novo Lipogenesis Jeffrey Pessin, PhD Judy R. & Alfred A. Rosenberg Professorial Chair in Diabetes Research Director, Diabetes Research Center Departments of Medicine and Molecular Pharmacology Albert Einstein College of Medicine

April 19, 2013 Role of Insulin Action and Resistance on Atherosclerosis George L. King, MD Chief Scientific Officer, Joslin Diabetes Center Professor of Medicine, Harvard Medical School

CHARLES HOLLENBERG SUMMER STUDENTSHIP PROGRAM: WEEKLY SEMINAR SERIES AND MINI-CONFERENCE 2013 Summer studentship recipients and their supervisors are required to participate in the Charles Hollenberg Summer Studentship Program which consists of a weekly Seminar Series and a half-day Mini-conference. The weekly seminars are held throughout June and July. Each hour-long seminar includes two 20 minute presentations prepared by two supervisors, followed by 5 minute presentations by their summer students describing how their project fits into the overall goals of the lab. All students present the results of their work at the end of the summer in a workshop format at the half-day Mini-conference. The BBDC would like to thank Dr. Jonathan Rocheleau for coordinating the 2013 Summer Studentship Program. The 2013 weekly seminar series and Mini-Conference program are as follows:


2013 Charles Hollenberg Summer Studentship Program Weekly Seminar Series 4:00 - 5:00 p.m.

MaRS/Toronto Medical Discovery Tower 101 College Street, 4th Floor Seminar Room 4-204

Date Time Student and Supervisor Presenting Title of Presentation

June 4, 2013 4:00 – 4:30 Wendy Ye & Dr. Denise Belsham Hormonal regulation of hypothalamic neurons

4:30 – 5:00 Louisa Ho & Dr. Michael Wheeler What are the defining features of a real beta cell?

June 11, 2013 4:00 – 4:30 Susanne Wang & Dr. Qinghua Wang Diminished GABA signalling in beta cells, a potential cause of development of diabetes in mice

4:30 – 5:00 Kelly Wu & Dr. Patricia Brubaker Glucagon-like peptide-1 secretagogues as a new therapeutic modality for type 2 diabetes

June 18, 2013 4:00 – 4:30 Emily Li & Dr. Amira Klip Lipotoxicity and inflammation in insulin resistance

4:30 – 5:00 Chris Shyi & Dr. Shirley X.Y. Wu Glucose-responsive Closed-loop Insulin Delivery

June 25, 2013 4:00 – 4:30 John Liu & Dr. Andras Nagy and Dr. Kristina Nagy

Reprogramming of pancreatic beta cells

4:30 – 5:00 Justin Wong & Dr. Farid H. Mahmud Celiac disease and Diabetes - Dietary Intervention and Evaluation Trial (CD-DIET)

July 9, 2013 4:00 – 4:30 Alyssa Molinaro & Dr. Derek van der Kooy

Pancreatic stem cells from the gut: a new treatment for diabetes

4:30 – 5:00 Catherine Lu & Dr. James Scholey Effect of Adiponectin on High Glucose Induced Oxidative Stress in Rat Kidney Mesangial Cells

July 16, 2013 4:00 – 4:30 Jonathan Lau & Dr. George Fantus The role of TxNIP in the development of diabetic nephropathy

4:30 – 5:00 Daanish Mulla & Dr. Sarah West The Pathophysiology of Exercise Intolerance in Children Post-Bone Marrow Transplant

July 23, 2013 4:00 – 4:30 Noah Hahn & Dr. Andrew Advani Endothelial dysfunction and albuminuria in diabetes

4:30 – 5:00 Deborah Koh & Dr. Richard E. Gilbert Secretory factors of early-outgrowth cells as novel treatment for diabetic neuropathy

July 30, 2013 4:00 – 4:30 Roman Zyla & Dr. Warren Lee Transcellular permeability of the microvascular endothelium to insulin – detection by novel methods and implications for insulin resistance

4:30 – 5:00 Alyssa Molinaro & Dr. Derek van der Kooy

Pancreatic stem cells from the gut: a new treatment for diabetes

2013 Charles Hollenberg Summer Studentship Program Mini-Conference Tuesday, August 6, 2013

1:00 – 5:00 p.m. Toronto Medical Discovery Tower

101 College Street, 4th Floor Seminar Room 4-204

1:10 – 1:15 p.m. Introduction: Dr. Jonathan Rocheleau, Program Coordinator

1:15 John Liu (Dr. Andras Nagy) Reprogramming of pancreatic beta cells

1:30 Alyssa Molinaro (Dr. Derek van der Kooy) Pancreatic stem cells from the gut: a new treatment for Type 1 Diabetes

1:45 Louisa Ho (Dr. Michael Wheeler) Zinc influx transporters (ZIPs) in MIN6 β cells


2:00 Susanne Wang (Dr. Qinghua Wang) Diminished GABA signaling in beta cells: a potential cause of diabetes in mice

2:15 Justin Wong (Dr. Farid H. Mahmud) Impact of a portable touch tablet and video to introduce clinical research and facilitate patient recruitment

2:30 Chris Shyi (Dr. Shirley X. Y. Wu) Glucose-responsive closed-loop insulin delivery

2:45 Refreshment Break

3:00 Daanish Mulla (Dr. Greg Wells) Assessing bone microarchitecture among paediatric HSCT survivors, with association to Type 2 Diabetes Mellitus

3:15 Roman Zyla (Dr. Warren Lee) Characterization of the fate of insulin in human microvascular endothelium

3:30 Deborah Koh (Dr. Richard E. Gilbert) Secretory factors of early-outgrowth cells as novel treatment for diabetic nephropathy

3:45 Noah Hahn (Dr. Andrew Advani) Unraveling the mechanisms behind albuminuria development in diabetes

4:00 Emily Li (Dr. Amira Klip) Saturated fat induces endothelial activation and increases monocyte adhesion

4:15 Catherine Lu (Dr. James Scholey) Effect of Adiponectin on High Glucose-Induced Oxidative Stress in Human Mesangial Cells

4:30 Jonathan Lau (Dr. George Fantus) The role of TxNIP in the development of diabetic nephropathy

4:45 Wendy Ye (Dr. Denise Belsham) The effects of CNTF on POMC gene expression in non-clonal hypothalamic POMC-GFP neurons

CONTINUING HEALTH EDUCATION WORKSHOPS The BBDC’s Continuing Health Education and Professional Development Committee regularly assesses the educational needs of diabetes health care professionals at University of Toronto-affiliated hospitals and designs informative workshops to meet their needs. The committee normally hosts one small, interactive workshop every two years. Workshops are open to diabetes health care professionals who are employed at the University of Toronto’s fully and community affiliated hospitals. The BBDC did not host a workshop in 2012/2013. DIABETES UPDATE

Diabetes Update is a biennial continuing education event which is planned by the Continuing Health Education and Professional Development Committee. This one-day event attracts hundreds of health care providers involved in diabetes education and management such as, but not limited to, physicians, nurses, dietitians and pharmacists from across Ontario. Diabetes Update 2013 was held on April 12, 2013 and was attended by almost 600 health care providers. The BBDC would like to thank the following for supporting Diabetes Update 2013: Gold Level Sponsors: Boehringer Ingelheim/Eli Lilly Diabetes Alliance, GlaxoSmithKline, Novo Nordisk; Silver Level Sponsors: Abbott, AstraZeneca, Bristol-Myers Squibb, LifeScan, Merck, Sanofi, Takeda; Non-Profit Sponsors: SickKids. The BBDC wishes to recognize Sun Life Financial, a proud supporter of the BBDC and Diabetes Update. The program is as follows:


Diabetes Update 2013 Friday, April 12, 2013

Metro Toronto Convention Centre South Building, 700 Level

7:45 AM Registration and Continental Breakfast

8:30 – 8:40 Welcome, Opening Remarks and Introduction: Dr. Rene Wong

Plenary Lectures

8:40 – 9:20 Empowering Patients to Self-manage Diabetes by Enhancing Health Care Provider Skills Ms. Durhane Wong Rieger

9:20 – 10:00 Management Strategies for the Patient With High Insulin Requirements Dr. Amir Hanna

10:00 – 10:30 Active Learning: Panel discussion - Diabetes Q & A

10:30 – 10:40 BBDC Diabetes Educator of the Year 2012 Award Presentation

10:40 – 11:10 Health break and networking

Concurrent Workshops 1

11:10 – 12:25 PM 1. Overview of Diabetic Nephropathy Dr. David Cherney and Ms. Dana Whitham

2. Managing Diabetes in Older Adults with Multi-Morbidity Dr. Ross Upshur

3. Challenging Cases in Insulin Pump Therapy: Looking at Approaches and Solutions Dr. Ian Blumer and Ms. Deborah Briggs-Heddleston

4. Optimizing the Quality of Diabetes Care: Learning From Gaps to Drive Improvement Dr. Brian M. Wong

5. Diabetes Nutrition Therapy: Where Have We Been and Where Are We Going? Ms. Sandi Williams

12:25 – 1:40 Lunch break

Plenary Lecture

1:40 – 2:20 Initial Combinations Therapy for Type 2 Diabetes: Is It Ready for Prime Time? Dr. Bernard Zinman

2:20 – 2:35 Active Learning: Q & A

2:35 – 3:05 Health break and networking

Concurrent Workshops 2

3:05 – 4:20 Repeat of concurrent workshops 1

4:20 Evaluation and adjournment


GUEST SPEAKERS

Deborah Briggs-Heddleston, RN, HBScN, CDE, CPT Diabetes Nurse Educator, Charles H. Best Diabetes Centre, Whitby

Durhane Wong-Rieger, PhD President & CEO, Institute for Optimizing Health Outcomes, Toronto

TORONTO SPEAKERS *University of Toronto

Ian Blumer, MD, FRCPC Medical Advisor, Charles H. Best Diabetes Centre, Whitby Author, Diabetes for Canadians for Dummies Lecturer, Faculty of Medicine* David Cherney, MD, PhD, FRCPC Clinician Scientist, Division of Nephrology, University Health Network Assistant Professor, Department of Medicine* Director, Renal Physiology Laboratory, University Health Network Amir Hanna, MB, BCh, FRCPC, FACP Professor Emeritus, Department of Medicine* Ross Upshur, MA, MD, MSc, CCFP, FRCPC Canada Research Chair in Primary Care Research Department of Family and Community Medicine* Sunnybrook Health Sciences Centre

Dana Whitham, RD, MSc, CDE, CPT Professional Practice Leader, Clinical Dietetics Registered Dietitian, Diabetes Comprehensive Care, St. Michael's Hospital Sandi Williams, MEd, RD, CDE, CPT Registered Dietitian, Diabetes Comprehensive Care Program, St. Michael's Hospital Brian M. Wong, MD, FRCPC Department of Medicine, Division of General Internal Medicine* Sunnybrook Health Sciences Centre Bernard Zinman, CM, MD, FRCPC, FACP Director, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Professor, Department of Medicine*

Plenary lecture at Diabetes Update 2013 Diabetes Update 2013 participants take a break to network with colleagues and meet event sponsors.


U OF T/BBDC DIABETES AND ENDOCRINOLOGY UPDATE FOR PRIMARY CARE PRACTITIONERS

This annual, one-day continuing education event is organized by Dr. Rene Wong, leader of the BBDC’s Continuing Health Education and Professional Development program and is co-hosted by the University of Toronto Division of Endocrinology and Metabolism and the Banting & Best Diabetes Centre. The event is targeted to health care providers in primary care and enrollment is normally limited to 100 participants in order to maximize learning potential. Several unique and innovative features highlight this course:

• Over 75% is devoted to interactive learning, including small group workshops and interactive question-and-answer sessions • Personalized learning: Opportunities to submit personal questions at the time of registration, during and after the event • Provision of clinical point-of-care tools to participants • The Doctor’s Lounge: Entire workshops during which participants can discuss their own cases informally with specialist

facilitators

Current and past programs can be found at http://www.cepd.utoronto.ca/diabetesendocrinology/.


http://www.cepd.utoronto.ca/diabetesendocrinology/

CORE LABORATORY The BBDC Core Laboratory provides high quality laboratory services to diabetes researchers at the University of Toronto involved in clinical and/or basic research. The lab also provides services to the wider scientific community including external academic and/or industry initiated research. The BBDC is expanding its Core Laboratory services to better serve the needs of BBDC researchers and affiliates as the BBDC expands its research enterprise. A steering committee of BBDC members based at Mount Sinai Hospital, The Hospital for Sick Children, and St. Michael’s Hospital have established close collaborations across institutions in order to offer a more complete lab inventory that will greatly support diabetes researchers. A list of current services and assays provided by the Core Lab is available on the BBDC’s web site at www.bbdc.org or by contacting the Core Lab directly:

Director: Dr. George Fantus • Phone: (416) 586-8665 • E-mail: [email protected] Associate Director: Dr. Azar Azad • Phone: (416) 586-8545 • E-mail: [email protected] Address: Mount Sinai Hospital, 600 University Avenue, 6th Floor, Room 600, Toronto, Ontario M5G 1X5

COMMUNICATIONS WEBSITE: BBDC.ORG Visitors to our site can view detailed information on all of our discovery and applied research programs, funding programs and funding decisions, educational activities, current diabetes research activities being conducted by our members, links to local and international diabetes meetings, and much more. NEWSLETTER The Centre distributes a newsletter entitled BBDC NEWS by e-mail to its members and those who have joined our e-mail list. Issues are distributed in September, December, March, and June of each year. The newsletter highlights upcoming BBDC events, funding opportunities, award results, seminars and more. Current and past issues are available on the BBDC’s web site. SOCIAL MEDIA

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ACKNOWLEDGEMENTS We would like to express our sincerest gratitude and appreciation to the following:

• The members of our Training and Research Excellence Committee and our Continuing Health Education & ProfessionalDevelopment Committee who volunteer their time to review applications for the Centre’s funding programs and toorganize educational events on behalf of the BBDC.

• The members of our Executive Committee, Discovery Research Steering Committee, and Applied Research SteeringCommittee.

• Dr. Jonathan Rocheleau for coordinating the 2013 Charles Hollenberg Summer Studentship Program.

OUR SUPPORTERS The Banting & Best Diabetes Centre gratefully acknowledges endowed financial support from the following private and corporate contributors:

C. H. Best Memorial Fund The Estate of Reuben & Helene Dennis The Estate of Marion Hamilton The Estate of Miriam Neveren The Estate of Dr. & Mrs. Edward A. Sellers The Estate of Mary E. Sharp The Estate of Archie Sopman Mr. Arthur Spoerri Mr. Stephen Yow Mok Shing Novo Nordisk

The Centre is also grateful to the following for contributions made between July 1, 2012 and June 30, 2013:

Abbott AstraZeneca Boehringer Ingelheim Bristol-Myers Squibb Canada Eli Lilly Canada GlaxoSmithKline Janssen LifeScan Merck Canada Novo Nordisk Pfizer Sanofi Diabetes SickKids Takeda Canada Toronto General & Western Hospital Foundation Sun Life Financial University Health Network Individuals who have donated to the Banting & Best Diabetes

Centre this past year.

200 Elizabeth Street, Eaton Building, 12E248, Toronto, Ontario, Canada M5G 2C4 Phone: (416) 978-4656 ⦁ [email protected] ⦁ www.bbdc.org


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