Available in over60 countries &26 languages

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Clinicallyprovenaction

The innovative product in gel and spray form

relieves muscle and joint pain based on the beneficial

properties of Cryotherapy - The Cold Method®

Pain relief that works® for:•MuscleAchesandSpasms• PaininWaist,Back,Shoulder,Neck,Knee,Hip,ElbowandAnkle• ArthritisandTendinitisPain• SoreMuscles• PainfromInjuryduringSportsandExercise• PainfulSprains,Strains,Bumps,PullsandBruises

IngredientsIsopropylAlcohol,Benthol&HerbalExtract(IlexParaguariensis).Camphor,Carbomer,Glycerine,Methylparaben,PropyleneGlycol,SiliconDioxide,Water,Triethanolamine,FD&Cyellow#5,FD&Cblue#1.

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Biofreeze® Pain Reliever delivers cold reliefClinically proven Cryotherapy made convenientIthaslongbeenestablishedthatcoldtherapy,or“cryotherapy",decreasespainandreducesinflammation.BiofreezePainRelieverisatopicalanalgesicthatdeliversthetherapeuticbenefitsofcryotherapyinaneffective,easy-to-useformula,throughUSP*-gradeingredientsforprovenanalgesiceffectiveness1.Clinicalevidence**atteststotheeffectivenessofBiofreezePainRelieverandaccountsforitsstandingasthe#1clinicallyusedandrecommendedtopicalanalgesicbyhandsonhealthcareprofessionalsinUSA.

(**)BishopBetal.2011.EffectsofBiofreezevs.iceonacute,non-complicatedneckpain(Abstract)ClinicalChiropractic14(4):153-54•BroskyJAetal.2012.Effectof3.5%mentholgelonkneepainandfunctioninginpatientswithkneeosteoarthritis(Abstract)JOrthopSportsPhysTher42(1):A106-7•Joharetal.2012.Acomparisonoftopicalmentholtoiceonpain,evokedtetanicandvoluntaryforceduringdelayedonsetmusclesoreness.IntJSportsPhysTher.7(3):314-22.•OliveJLetal.2010.VascularconductanceisreducedaftermentholorcoldapplicationClinJSportMed20(5):372-6.•ToppRetal.2011.Effectoftopicalmentholonipsilateralandcontralateralsuperficialbloodflowfollowingaboutofmaximumvoluntarymusclecontraction.IntJSportsPhysTher6(2):83-91•ToppRetal.2011.Comparisonoftheeffectsoficeand3.5%mentholgelonbloodflowandmusclestrengthofthelowerarmJSportRehabil20:355-366•ZhangJetal.2008.EffectsofBiofreezeandchiropracticadjustmentsonacutelowbackpain:apilotstudyJChiropracticMed7:59-65

(*) USP: An indicator of qualityTheUnitedStatesPharmacopeia(USP)setsstandardstoensurethequalityofmedications,foodingredients,andhealthcareproducts.BiofreezePainRelieverisformulatedwithUSP-gradementhol,camphor,isopropylalcohol,andwater.OurchoiceofUSP-gradeingredientsdistinguishesBiofreezePainRelieverfromothertopicalanalgesicsandistestimonytoourcommitmenttoquality.

Mechanism of actionThe counter - irritant / Gate Control TheoryTraditionalthinkingisthatthepain-relievingmechanismofactionofmenthol,aningredientinBiofreezePainReliever,resultsfromacounter-irritanteffect.Simplyput,acounter-irritanthasaneffectofoverridingnoxiouspainsignalstravelingtothebrainthroughaprocessmodulatedbetweenpain-transmittingandnon-paintransmittingneurons.Thisprocess,knownas“gatecontrol”or“gating,”wasfirstdescribedbyMelzackandWall.2Gatecontroltheoryisbasedontheunderstandingthatpainistransmittedbytwokindsofafferentnervefibers.OneisthelargermyelinatedA-deltafiber,whichcarriesquick,intense-painmessages.Theotheristhesmaller,unmyelinated“C”fiber,whichtransmitsthrobbing,chronicpain.Athirdtypeofnervefiber,calledA-beta,is“nonnociceptive,”meaningitdoesnottransmitpainstimuli.ThegatecontroltheoryassertsthatsignalstransmittedbytheA-deltaandCpainfiberscanbethwartedbytheactivation/stimulationofthenonnociceptiveA-betafibersandthusinhibitanindividual’sperceptionofpain.Morerecently,researchershavediscoveredthatmentholfurtherstimulatestheTRPM8coldreceptors.Eventhoughithaslongbeenacceptedthatcoolingandcoldcaninduceanalgesia,themechanismhasbeenpoorlyunderstood.Now,asscientistshavecontinuedtoisolatethesespecificheat-sensitivetransientreceptorpotential(TRP)channelswithinoursensoryneuronswearenowabletohaveamuchbetterunderstandingofthebody’scutaneoustemperaturedetection.WiththeisolationandfurtherstudyofthesespecificTRPM8receptorsthereisstrongerevidencesupportingthebenefitsachievedwiththecoolingeffectofmentholinfunctioningasatopicalanalgesicwhileactivatingthesereceptorsandtheresultingconsequentpainrelief.

Like ice, only betterThe pain - relieving power of menthol

Iceisthetime-honoredmeansofeffectivelydeliveringcryotherapy,buticedoeshavedisadvantages.Itcancausemusclestiffness,skinirritation,temporarypainandnumbness,anditgenerallyrequiresthepatienttoremainstationary.BiofreezePainRelieverhasbeenshowntobeaseffectiveasicewithoutthedisadvantages.3Likeice,BiofreezePainRelieverreducespainandinflammation.OnestudydeterminedthatbloodflowdecreasedintheradialarteryfiveminutesafterBiofreezePainRelieverwasappliedtotheforearm;20minuteswererequiredforicetoinducethesameresult.WhileBiofreezereducedbloodflowmuchquickerthanice,thereductionlastedlongerintheicecondition.Thisquickreductionmaybeagreatbenefitintheveryacutestagesofinjury,butmoreresearchisneeded.4Inanotherstudy,patientswithbilateralneckpainpreferred,byan8-to-1margin,treatmentwithBiofreezePainRelievertotreatmentwithice,andnineoutoftenpatientsfeltthatBiofreezePainRelieverwastwiceaseffectiveandthatrelieflastedlonger,comparedtoice.5Theshort-termpainreliefprovidedbyBiofreezePainRelieverfacilitateseaseofmovement,whichcanpromotefaster,long-termhealingandrecovery.Itmaybeusedtocontrolpainduringtherapyandbypatientsandclients,athomeoron-the-go.Whenusedbeforeexerciseand/ortherapy,BiofreezePainRelieverpromotespain-freemovement.Afteractivity,BiofreezePainRelieversoothessoremusclesandjoints.6

Cryotherapywithout the ice

side effects

References1. GaleottiN,DiCesareMannelliL,MazzantiG,BartoliniA,GhelardiniC. Menthol:anaturalanalgesiccompound.NeuroscienceLetters. 2002Apr12;322(3):145-8.2. MelzackR,WallPD.Painmechanisms:anewtheory.Science. 1965Nov19;150(699):971-9.3. Toppetal.Effectsofmentholonskeletalmusclebloodflow.4. ToppR,WinchesterLJ,SannesSH,MinkAM,KaufmanJS, JacksDE.AcomparisonofBiofreezeandiceonbloodflow,pain andmusclefunction.5. BishopB,GreensteinJ,ToppR.EffectsofBiofreezevs.iceon acute,non-complicatedneckpain.6. SarabonN.ReportsonthefirstobservationsonBiofreezetopical analgesicinSlovenianprofessionalsportspractice.7. StanosS.Overviewoftopicalanalgesics.PainMedicineNews. 2009Feb:1-6.

Pain is Perceived

Pain is NOT Perceived

pain

PainSignal

Brain

pain

PainSignal

Brain

The Melzack-Wall Pain GateThebrain’sperceptionofpaindependsontheinteraction—withinthelaminaeofthespinalcord—ofCandA-deltanervefibers(pain-transmitting)withA-beta

nervefibers(non-pain-transmitting).StimulatingtheA-betanervefibersultimatelyactivatestheinhibitoryinterneuronand“closesthegate”topain.

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Cold therapy for every settingA natural, targeted route to relief

Patient care:ApplyBiofreezePainRelieverbefore,during,andaftertreatmentortherapytofurtherenhanceyourlevelofhands-onprofessionalcare.Likewise,recommendBiofreezePainRelieveraspartofyourpatient’sorclient’sin-hometreatmentplan.Suchas:• adjunctivemodalitywiththerapies • GrastonTechnique®*• Orthotics • SpinalDecompression

Pain management: Patientsandclientshealmoreslowlywhenpainhinderstheirabilitytoperformrehabilitationtherapiesandexercises.BiofreezePainReliever,massagedintosoremusclesandjoints,canmakeiteasierforyourpatientsandclientstofullyparticipateintreatmentsessions.Bydeliveringfastpainrelief,BiofreezePainRelievercanaidinyourtreatmentofinjuriesandchronicproblemsthattraditionallycallforiceandbreathablewraps.

Exercise and training: BiofreezePainRelievercanaidexerciseandtraining-andeasethesometimesuncomfortableaftereffects-byrelievingpaintoincreaserangeofmotion.ApplyBiofreezePainRelieverbeforeexercisetotakesorenessoutofmusclesand/oraftercool-downroutinestominimizenext-dayachesandpains.Forsoremuscles,applydirectlytotheareabeforeand/orafterexercise.Combinewithmassage,asneeded.

(*)GrastonTechniqueisaregisteredtrademarkoftheGrastonCorporation

1 Exerciseoractivity canleadtosoreness, discomfort,pain, orinjury

2Soreness,discomfort, pain,orinjurylimitsour abilitytoexercise

3Limitingexercise decreasesactivity leveland/orour optimalfunctionality

4 BiofreezePainReliever reducessoreness, discomfort,orpaintohelp facilitateexerciseoractivity

How Biofreeze Pain Reliever manages the Pain Cycle

The PainCycle

Dosage - How to useAdults: Applytotheaffectedareaupto4timesaday.Children:Askformedicaladvicebeforeuse.Pregnancy: Askformedicaladvicebeforeuse

Evidence encourages the use of topical analgesicsThe trend is toward targeted reliefToday,throughoutthepainmanagementcommunity,theshiftistowardtheuseoftopicalanalgesicsandawayfromsystemicpainrelievers.Fuelingthistrendisevidence-basedresearchlinkingcurrentlyavailablesystemicpainrelieverstoadverseevents.7NSAIDs,COX-2inhibitors,andopioidscanaffectthegastrointestinaltract,heart,kidneys,andotherorgans,aswellascognition.

Conversely,topicalanalgesics,suchasBiofreezePainReliever,delivertargetedpainreliefwithlowlevelsofsystemicabsorptionandthereforelessriskforsystemictoxicityand/ordruginteraction.Pain-managementcliniciansareencouragedtoconsiderandrecommendtopicalanalgesicsaseffective,saferalternativestosystemicmedications.7

•Roll-On:RollerapplicationallowseffectivedeliveryofBiofreezegeltosmallermusclesandjointsthroughoutthebody.Themassagingactionoftherollerballcanbeusedtostimulatetriggerpointsintheaffectedarea.•Spray:BiofreezeCryospray®permitseasy,effectiveapplicationwithoutdirectbodycontact,helpingpatientsathomegainaccesstohard-to-reachbodyareassuchastheback.•Gel:Gel-dispensingtubeisparticularlywell-suitedforhands-onmassageapplications(particularlylargermusclesandjoints).

One effective pain relieverin three different formats

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Performance Health ANZ(formerly Patterson Medical)

To order call 1300 473 422sales@performhealth.com.au

performhealth.com.au

For more information visit:www.biofreeze.com www.thera-bandacademy.com

Biofreeze® is a trademark owned by the Hygenic Corporation or its affiliatesand may be registered in the UnitedStates and other countries.All rights reserved. ©2012