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Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution – Non- Commercial 3.0 License: http://creativecommons.org/licenses/by-nc/3.0/ We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The attribution key found at the end of the module provides information about how you may share and adapt this material. Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content. For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use. Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition. Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

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Page 1: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Author(s): Michael Hortsch, Ph.D., 2010

License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution – Non-Commercial 3.0 License: http://creativecommons.org/licenses/by-nc/3.0/

We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize your ability to use, share, and adapt it. The attribution key found at the end of the module provides information about how you may share and adapt this material.

Copyright holders of content included in this material should contact [email protected] with any questions, corrections, or clarification regarding the use of content.

For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use.

Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosis or a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Please speak to your physician if you have questions about your medical condition.

Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.

Page 2: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Histology of Blood and Bone Marrow –Second Look

Michael Hortsch, Ph.D.

Department of Cell and Developmental Biology

University of Michigan

© 2010 Michael Hortsch

Page 3: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of cell found in the blood.Approximately, how many of these cells

are normally found per ml of blood ?

On average the diameter of these cells is … ?

Page 4: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Where are these cell fragments produced ?

Identify the small structures encircled by the black stippled lines.

Page 5: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of leukocyte found in the blood.

How abundant (in percent) is this cell type in a normal blood

leukocyte population ?

Summarize the most important functions of this cell type ?

Page 6: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of leukocyte found in the blood.

How abundant (in percent) is this cell type in a normal

blood leukocyte population ?

Briefly summarize the most important functions of this cell type ?

Page 7: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of leukocyte found in the

blood.

How abundant (in percent) is this cell type

in a normal blood leukocyte population ?

Briefly summarize the most important functions of this cell type ?

Page 8: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of cell found in the blood.

How abundant (in percent) is this cell type in a normal blood

leukocyte population ?

Summarize the most important functions of this cell type ?

Page 9: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of cell found in the blood.

How abundant (in percent) is this cell type in a normal

blood leukocyte population ?

Briefly summarize the most important functions of this cell type ?

Page 10: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of cell found in the blood.

How abundant (in percent) is this cell type

in a normal blood leukocyte population ?

Briefly summarize the most important functions of this cell type ?

Page 11: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of cell found in the blood.

How abundant (in percent) is this cell type in a normal blood

leukocyte population ?

Briefly summarize the most important functions of this cell type ?

Page 12: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this type of cell found in the blood.

How abundant (in percent) is this cell type in a normal blood leukocyte

population ?

Briefly summarize the most important functions of this cell type ?

Page 13: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify the three leukocytes in this

image.

How many agranulocytes can you identify in this

image ?

Page 14: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify the two leukocytes in this image and briefly outline the physiological processes they are involved in.

Image courtesy of A.K. Christensen, University of Michigan

Page 15: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

The white blood cell in middle is the precursor of at least one of the cells in the periphery. Which of the other cells is/are derived from the cell in

the middle ? (Warning! The images are not shown to scale.)

PAS & Azure II stain

Page 16: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

The white blood cell in middle can possibly be the precursor cell of at least one of the cells in the periphery. Which of the other cells is/are derived from this cell ? (Warning! The images are only approximately to scale.)

PAS & Azure II stain

Page 17: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Page 18: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Briefly summarize the most important functions of this cell fragment ?

Page 19: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Page 20: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Page 21: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Page 22: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Page 23: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify this cell type

Page 24: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify the two leukocytes that are outlined by the dashed lines.

These two cells undergo a specific process. Name this process.

Endothelial cellEndothelial cell

Endothelial cell

Page 25: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

What are the spaces called that are indicated by the black arrows and dashed lines ?

Page 26: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

What are the cellular areas called that are indicated by the white arrows and dashed lines ?

Page 27: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Identify the 4 cells marked by the dashed ovals. Where do these cells reside and what is

the major product of these cells ?

Page 28: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Describe the functional differences

between these two images of bone

marrow.

Page 29: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

Slide 3: Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100%

Slide 4: Michigan Histology Hematology Lab Normal1 63X.svs

Slide 5: Michigan Histology Hematology Lab Normal1 63X.svs 100%

Slide 6: Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100%

Slide 7: Michigan Histology Hematology Lab Normal1 63X.svs 100%

Slide 8: Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100%

Slide 9: Michigan Histology Hematology Lab Normal Smear 86X thick.svs 100%

Slide 10: Image courtesy of Ryan Brand

Slide 11: Image courtesy of A.K. Christensen

Slide 12: Image courtesy of Ryan Brand; Plasma cell Michigan virtual slide collection 029-1_HISTO_40X.svs;Macrophage Michigan virtual slide collection 026_HISTO_40X.svs, Mast cell Michigan virtual slide collection 160_HISTO_40X.svs; fat cell Michigan Histology 152_HISTO_40X.svs; Basophil Hematology Lab Normal Smear 86X thick.svs; Neutrophil 029-1_HISTO_40X.svs;

Slide 14: Michigan Histology 122 - Blood_001.svs

Slide 15: Michigan Histology 125 - Blood_001.svs platelet

Slide 16: Michigan Histology 126 - Neutrophil_001.svs

Slide 17: Michigan Histology 128 - Monocyte_001.svs

Slide 18: Michigan Histology 129 - Lymphocyte_001.svs

Slide 19: Michigan Histology 130 - Eosinophil_001.svs

Slide 20: Michigan Histology 131 - Basophil_001.svs

Slide 21: Michigan Histology 132 - Blood_001.svs

Slide 22: Michigan Histology UCSF083_40X.svs

Slide 23: Michigan Histology UCSF083_40X.svs

Slide 24: Michigan Histology possibly slide 048_HISTO_40X.svs

Slide 25: Michigan Histology 94_HISTO_40X.svs gallbladder wall 22% and 79%

Attributions by Slide

Slide 13: Image courtesy of Ryan Brand; Plasma cell Michigan virtual slide collection 029-1_HISTO_40X.svs; Macrophage Michigan virtual slide collection 026_HISTO_40X.svs; Michigan virtual slide collection 160_HISTO_40X.svs; Basophil Hematology Lab Normal Smear 86X thick.svs; Neutrophil 029-1_HISTO_40X.svs;

Page 30: Author(s): Michael Hortsch, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution

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