August 1-2, 2017

Buffalo, New York

Order of Events

Tuesday August 1, 2017 iSEED and CTSI Final Research Presentations

11:00 AM-12:00 PM: Poster Session Biomedical Education Building Atrium

12:00 PM-12:45 PM: Lunch

(all CLIMB UP students, plus iSEED and CTSI mentors invited) Lippschutz Room

1:00 PM-3:15 PM: Oral Presentations

144 Farber Hall

Wednesday August 2, 2017 ASPET SURF/CLIMB PRO Final Research Presentations

11:00 AM-12:00 PM: Poster Session Biomedical Education Building Atrium

12:00 PM-12:45 PM: Lunch

(all CLIMB UP students, plus ASPET SURF and CLIMB PRO mentors invited) Lippschutz Room

1:00 PM-3:15 PM: Oral Presentations

144 Farber Hall

Oral Presentations Tuesday August 1, 2017

Institute for Strategic Enhancement of Educational Diversity (iSEED)

College of Arts and Sciences

1:00 pm Quinn Carroll Type of Traumatic Life Event Does Not Influence Future Posttraumatic Growth* Summer Mentor: Jennifer Read, PhD, Department of Psychology Undergraduate Institution: University at Buffalo Major: Psychology/Cognitive Neuroscience Hometown: Buffalo, New York Academic/Career Aspirations: PhD in Clinical Psychology *Quinn’s research was also supported by the UB Clinical and Translational Science Institute

1:10 pm

Aylin Flores Distinguishing Whether Rif2 and Orc4 Subfunctionalized or Neofunctionalized After Duplication Summer Mentor: Laura Rusche, PhD, Department of Biological Sciences Undergraduate Institution: University of Texas at Rio Grande Valley Major: Biomedical Science Hometown: Olmito, Texas Academic/Career Aspirations: To pursue an MD/PhD and become a cardiothoracic surgeon. Personal Motto: One simple word, "work ethic"

School of Dental Medicine

1:20 pm LeDaniel Sims

Bioengineering with Nano Scaffolds for Tissue Regeneration Summer Mentor: Praveen Arany, PhD, Department of Oral Biology Undergraduate Institution: Tougaloo College Major: Biology Hometown: Brandon, Mississippi Academic/Career Aspirations: Dentistry Personal Motto: Having tenacity is a virtue.

1:30 pm Toneia Washington Analyzing Oral Wound Healing On Murine Macrophage Cell Lines Using Photobiomodulation Summer Mentor: Praveen Arany, PhD, Department of Oral Biology Undergraduate Institution: Winston-Salem State University Major: Chemistry Hometown: Fayetteville, North Carolina Academic/Career Aspirations: To become a dentist. Personal Motto: It may seem like a lot, but you are doing all of this for a reason.

Jacobs School of Medicine and Biomedical Sciences

2:00 pm Adriana del Mar Pons Calvo

Macrophage Acetylcholine Receptor Regulation of TNF Production During Neuropathic Pain

Summer Mentor: Tracey Ignatowski, PhD, Department of Pathology and Anatomical Sciences Undergraduate Institution: University of Puerto Rico at Cayey Major: Natural Sciences Hometown: Arroyo, Puerto Rico Academic/Career Aspirations: Finish my bachelor's degree in Natural Sciences, get my minor concentration in Math and then apply to graduate school and get a PhD in Immunology.

Personal Motto: "A smooth sea never made a skillful sailor"

School of Nursing

2:10 pm Samantha Manahan American Indians and Alzheimer's Disease: A Systematic Review 2006-2016 Summer Mentor: Margaret Moss, PhD, JD, RN, Associate Professor Undergraduate Institution: University at Buffalo Major: Health and Human Services Hometown: Ridgewood, New York Academic/Career Aspirations: Public Health Nurse Personal Motto: Be good to others and to yourself.

BREAK

School of Engineering and Applied Sciences

1:40 pm Melinda Tiao Scanning Electron Microscopy (SEM) Assessment of Endothelialization in Elastase Aneurysm Models Treated with a Retrievable Asymmetric Flow Diverter (RAFD) Summer Mentor: Ciprian Ionita, PhD, Department of Biomedical Engineering Undergraduate Institution: University at Buffalo Major: Biomedical Engineering Hometown: Buffalo, New York Academic/Career Aspirations: To work in a medical profession in order to

provide healthcare for everyone no matter their position, either in a place of need or as a service member Personal Motto: Stay strong and never give up

1:50 pm Toni Warnick Histological Evaluation of Elastase-Induced Rabbit Aneurysms Treated with Retrievable Asymmetric Flow Diverter [RAFD] Summer Mentor: Ciprian Ionita, PhD, Department of Biomedical Engineering Undergraduate Institution: Clemson University Major: Bioengineering Hometown: Sanborn, New York Academic/Career Aspirations: Master's degree in Bioengineering Personal Motto: The hard way is the easy way.

School of Pharmacy and Pharmaceutical Sciences

2:30 pm Lindsey Euscher The Role of Protein Aggregation in the Development of Inhibitors to Eloctate in Hemophilia A Summer Mentor: Sathy V. Balu-Iyer, PhD, Department of Pharmaceutical Sciences Undergraduate Institution: University at Buffalo Major: Pharmacology and Toxicology Hometown: Buffalo, New York Academic/Career Aspirations: I want to go to medical school to become a pediatric hematologist/oncologist Personal Motto: Go for it. No matter how it ends, it was an experience.

2:40 pm Brianna Scotland Murine mRNA Expression of a Novel, Orphan Transporter: Monocarboxylate Transporter 6 (Mct6) Summer Mentor: Marilyn E. Morris, PhD, Department of Pharmaceutical Sciences Undergraduate Institution: University of the Virgin Islands Major: Biology Hometown: Frederiksted, Virgin Islands Academic/Career Aspirations: Pharmacologist Personal Motto: Everything happens for a reason

Clinical and Translational Research Institute (CTSI)

2:50 pm Dorian Frazier Influence of Starting Material on Human Monocyte-Derived Dendritic Cells Summer Mentor: Jason Muhitch, PhD, Roswell Park Cancer Institute Undergraduate Institution: University of Maryland, Baltimore County Major: Biology Hometown: Bowie, Maryland Academic/Career Aspirations: My goal is to get an MD/PhD and pursue a path in cancer research. Personal Motto: Just keep swimming!

3:00 pm Nathan Greene A Data Driven Approach to Studying the Weekend Effect in ICU Patients Receiving Unfractionated Heparin Summer Mentor: Jason Davies, MD, PhD, Department of Neurosurgery Undergraduate Institution: Mercer University Major: Biomedical Engineering Hometown: Ringgold, Georgia Academic/Career Aspirations: Become an MD Personal Motto: Fail forward.

3:10 pm Coral Sanchez Malave Novel Methods of Designing Liposome-Based Drug Delivery System into the Macrophages Summer Mentor: Umesh Sharma, MD, PhD, Department of Cardiology Undergraduate Institution: University of Puerto Rico at Mayaguez Major: Biology Hometown: San Sebastian, Puerto Rico Academic/Career Aspirations: Become an MD/PhD Personal Motto: Experience does for the soul what education does for the mind.

Wednesday August 2, 2017

ASPET Summer Undergraduate Research Fellowship (SURF)

1:00 pm Moriah Cobb Exploring Molecular Mechanisms of Adolescent Sucrose Exposure Summer Mentor: David Dietz, PhD, Department of Pharmacology and Toxicology Undergraduate Institution: California State University, Bakersfield Major: Psychology Hometown: Bakersfield, California Academic/Career Aspirations: PhD in Neuroscience Personal Motto: “You miss 100% of the shots you don't take.”

1:10 pm Caitlin Deubell Flow Cytometry Based Analytical Method for Quantitation of Blinatumomab (Blincyto®) in Mouse Plasma Summer Mentor: Dhaval Shah, PhD, Department of Pharmaceutical Sciences Undergraduate Institution: Allegheny College Major: Global Health Studies Hometown: Buffalo, New York Academic/Career Aspirations: After taking a year off from school after graduation I hope to attend medical school and one day practice medicine in

a rural community hospital Personal Motto: "The people who are crazy enough to think they can change the world are the ones who do." -Steve Jobs

1:20 pm

Israh Ibrahim Automated Detection and Quantification of Red Blood Cells from Peripheral Blood Smears

Summer Mentor: Pinaki Sarder, PhD, Department of Pathology and Anatomical Sciences Undergraduate Institution: Medaille College Major: Biology Hometown: Sudan Academic/Career Aspirations: Attend medical school Personal Motto: “Nothing is impossible, the word itself says 'I'm possible'!”-

Audrey Hepburn

1:30 pm Zuiru Lin Discovery of Small Anti-Cancer Molecule Targeting Estrogen Receptor Summer Mentor: Rajendram V. Rajnarayanan, PhD, Department of Pharmacology and Toxicology Undergraduate Institution: University at Buffalo Major: Medicinal Chemistry Hometown: Williamsville, New York Academic/Career Aspirations: Become a good chemist to discover better medication for specific diseases. Personal Motto: I believe I can do it.

1:40 pm Michael Olyer Inhibition of Antibiotic Resistance Induced by the SOS Response: The Effects of Metal Ionophores Summer Mentor: John Crane, MD, PhD, Departments of Medicine, Pharmacology and Toxicology, Microbiology and Immunology Undergraduate Institution: University at Buffalo Major: Biotechnology Hometown: Avon, New York Academic/Career Aspirations: Translational research in microbiology and immunology

Personal Motto: Science is the answer to "How?", while God is the answer to "Why?".

1:50 pm Garrett Sheehan Impact of Carbamate Insecticides and Phthalate Diester Exposure on Melatonin Receptor-Mediated Inhibition of CREB Phosphorylation Summer Mentor: Margarita L. Dubocovich, PhD, and Rajendram V. Rajnarayanan, PhD, Department of Pharmacology and Toxicology Undergraduate Institution: University at Buffalo Major: Biological Sciences and Psychology Hometown: Buffalo, New York Academic/Career Aspirations: I would like to become a PI

2:00 pm Nadin Zejnilovic The Role of TAAR-1 on the Modulation of Circadian Rhythms in Mice Summer Mentor: Margarita L. Dubocovich, PhD, Department of Pharmacology and Toxicology Undergraduate Institution: University at Buffalo Major: Pharmacology and Toxicology Hometown: Queens, New York Academic/Career Aspirations: Pursue a Master’s degree in cancer sciences Personal Motto: After patience beautiful things await.

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CLIMB PRO (Professional)

2:20 pm Justin Harvey Increasing Colorectal Cancer Screening Rates- A Quality Improvement Initiative Summer Mentor: Roberto Diaz Del Carpio, MD, Department of Medicine Undergraduate Institution: University at Buffalo Major: Biomedical Sciences Hometown: Buffalo, New York Academic/Career Aspirations: Become a physician

2:30 pm Godstime Nwatu-Ugwu Regulation of the Extracellular Matrix in Aging and Disease Summer Mentor: Te-Chung Lee, PhD, Department of Biochemistry Undergraduate Institution: Stony Brook University Major: Biology Hometown: Middle Island, New York Academic/Career Aspirations: Become a medical doctor Personal Motto: Everything happens in God's time

2:40 pm Elizabeth Okundaye Predictive Immunoprofiling for Precision Based Immunotherapy in Triple Negative Breast Cancer Summer Mentor: Wilfrido Mojica, MD, Department of Pathology and Anatomical Sciences Undergraduate Institution: St. Mary’s College of Maryland Major: Biology Hometown: Baltimore, Maryland Academic/Career Aspirations: Work in the field of medicine with a concentration in Global Health Personal Motto: Listen to understand

2:50 pm Kiam Preston, Jr. Investigation of Nonalcoholic Steatohepatitis (NASH): D-amino Acid Inducing D-amino Acid Oxidase in Hepatocytes Summer Mentor: Lixin Zhu, PhD, Department of Pediatrics Undergraduate Institution: Towson University Major: Molecular Biology, Biochemistry & Bioinformatics Hometown: Baltimore, Maryland Academic/Career Aspirations: Get my MD/PhD to pursue research with a focus in immunology or virology as well as become a pediatric doctor. Personal Motto: Nobody's built like you. You design yourself.

3:00 pm Agnele Sewa The Role of p38-γ in Myelination and Remyelination Summer Mentor: M. Laura Feltri, MD, Departments of Biochemistry and Neurology, Hunter James Kelly Research Institute Undergraduate Institution: Brandeis University Major: Biochemistry/Health Science and Social Policy(minor) Hometown: Atlanta, Georgia Academic/Career Aspirations: To pursue a MD-PhD in hopes of making medical treatments more accessible. Personal Motto: Even the missteps are a step forward.

2017 CLIMB UP Leadership

Margarita L. Dubocovich, PhD, Founder and Director

Rajendram V. Rajnarayanan, PhD, Associate Director

Megan Blake, iSEED Coordinator

David Hoekstra, PhD, CLIMB Educational Advisor

Liz Marshall, CLIMB UP Program Coordinator

David Shubert, PhD, Lab Skills Course Instructor

Deborah Timineri, Lab Skills Course Instructor

Research Communications Workshop Mentors

Shannon Clough, PhD Grant Glatfelter David Hoekstra, PhD Spencer Rosario Debbie Timineri

Contact Us

Phone: 716.829.0414 or 716.829.3543

Email: climb@buffalo.edu

Web: www.buffalo.edu/climb/climb-up

Acknowledgments CLIMB UP would not be possible without the generous support of our sponsors:

CLIMB PRO (Professional)

Jacobs School of Medicine and

Biomedical Sciences

Institute for Strategic

Enhancement of

Educational Diversity

(iSEED)

Summer Undergraduate Research Fellow (SURF),

American Society for Pharmacology and Experimental Therapeutics UB Jacobs School of Medicine and Biomedical Sciences and

School of Pharmacy and Pharmaceutical Sciences

UB Clinical and Translational Science Institute (CTSI)

Jackson Heart Study

Tougaloo College

California State

University at

Bakersfield

MARC U*STAR

Program

University of the Virgin Islands

MARC Program

Winston-Salem State

University RISE Program

Medgar Evers College

RISE Program;

Brooklyn, NY

Special thanks to our phenomenal group of UB faculty who

took the time to mentor CLIMB UP students this summer.

Your dedication to the next generation of scientists is the

driving force behind our program, and we are so very grateful!