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eComponent Online MaterialAppendixContents:

1. Text Supplement of Methodology2. Table A1: Clinical series used in the analysis3. References for Table A1

Methodology:Calculating outcome: Utilities associated with each outcome allow us to calculate quality of life. Quality-adjusted life years (QALYs) represent a cumulative measure of both quality and quantity of life. For example, if the subject has 5 years with a utility of 0.4, the product is 2 QALYs. If the next 5 years are associated with a utility of 0.3, the product is 1.5 QALYs, resulting in a total of 3.5 QALYs for the entire 10 year period. Our calculations ignore transient perioperative complications, whose effects over the 10 year period are negligible. Successful seizure control and perioperative complications are assumed to begin immediately after surgery. Late mortality and morbidity, as well as reoperations are assumed to occur midway through the follow-up period.

If there are no perioperative complications and the subject has an Engel score of 1 postoperatively (the ideal surgical result), her utility is 0.754 (see Table 2). If there are no late complications and no need for further epilepsy surgery over 10 years, the subject will have a total of 7.54 QALYs. Any adverse events lower this number accordingly.

Table A1: Clinical series used in the analysis

1st AuthorYr Published

# of cases operated

Abubakr A(1) 2006 21Acosta I(2) 2008 7Adams S(3) 2012 72Akanuma N(4) 2003 125Al-Kaylani M(5) 2007 150Alarcon G(6) 1997 38

Alonso-Nanclares L(7) 2005 6

Alpherts, WCJ(8) 2006 85



Alpherts, WCJ(11) 2000 226Alsaadi TM(12) 2003 14Alsaadi TM(13) 2001 18Alsaadi TM(14) 2003 49

Andrade-Valenca LP(15) 2008 59Anhoury S(16) 2000 167Assaf BA(17) 1999 75Assaf BA(18) 2004 9Au L(19) 2011 4Baldauf CM(20) 2006 41Bartolomei F(21) 2010 23Bauer J(22) 2000 7Baxendale S(23) 2012 70Bekelis K(24) 2013 36Bell, M.(25) 2009 44

Benbadis SR(26) 2003 29Berg AT(27) 1998 178Berkovic SF(28) 1995 135

Bidet-Caulet, A.(29) 2009 26Bjornaes H(30) 2005 91Blume WT(31) 1997 100Blumer D(32) 1998 44Boling W(33) 2006 15Bonelli SB(34) 2012 44Bonilha L(35) 2007 43Bonilha L(36) 2004 30Borelli P(37) 2008 66

Brekelmans GJ(38) 1998 44Brodbeck V(39) 2010 5Bronen RA(40) 1997 55

Buchfelder M(41) 2002 23

Buckingham SE(42) 2010 268

Burgerman RS(43) 1995 48Burneo JG(44) 2003 6Burneo JG(45) 2006 252Burneo JG(46) 2005 64Burneo JG(47) 2003 78Busch RM(48) 2011 211Busch RM(49) 2008 12

Cankurtaran ES(50) 2005 22Carran MA(51) 2003 46Cascino GD(52) 1995 165Castro LH(53) 2008 76Cendes F(54) 1997 7

Chabardes S(55) 2005 48

Chelune GJ(56) 1998 1034

Cheung MC(57) 2009 4

Chkhenkeli SA(58) 2007 67Choi JY(59) 2003 47Chung SS(60) 1998 72

Clusmann H(61) 2002 98

Cohen-Gadol, A(62) 2006 399Coppens E(63) 2006 17Cukiert A(64) 2000 16Cukiert A(65) 2010 45Cukiert A(66) 2009 212Cukiert A(67) 2002 100Cunha I(68) 2003 19Cunha I(69) 2010 32

da Conceição PO(70) 2012 10Davies KG(71) 2005 24

de Araújo Filho GM(72) 2012 115

Dericioglu N(73) 2010 70Derry PA(74) 2000 39

Di Gennaro G(75) 2004 62Diehl B(76) 2004 46Doss RC(77) 2000 63Doss RC(78) 2004 107Drane DL(79) 2008 16Dulay MF(80) 2006 90Dulay MF(81) 2009 83Dulay MF(82) 2009 75Dunlea O(83) 2010 74Dupont S(84) 2006 88Dupont S(85) 2008 5Dupont S(86) 2000 30

Elsharkawy AE(87) 2011 61Elshorst N(88) 2009 59Engel J Jr(89) 2012 15Engman E(90) 2006 25Engman E(91) 2004 54

Erickson JC(92) 2005 84Erickson JC(93) 2006 9

Faleh-Tamimi A(94) 2002 10

Falowski SM(95) 2012 222Fauser S(96) 2006 12

Feigenbaum JD(97) 2004 30

Ferguson SM(98) 2006 45

Fernandez A(99) 2004 26

Ferrari-Marinho T(100) 2012 157Filho GM(101) 2012 115Foldvary, N(102) 2000 79Fried I(103) 1995 90George L(104) 2009 172

Ghacibeh G(105) 2013 18Gilliam F(106) 2000 64Gilliam F(107) 1997 78Gilliam F(108) 1999 125Gomceli YB(109) 2006 73

Grammaldo LG(110) 2009 82Griffin CT(111) 2004 30Grivas A(112) 2006 7

Grunwald T(113) 1999 70

Guangming Z(114) 2009 62

Guarnieri R(115) 2009 186Gyimesi C(116) 2010 42

Haegelen, C(117) 2013 8Halasz P(118) 2004 19

Hamberger MJ(119) 2005 16Hardy SG(120) 2003 118Hartzfeld P(121) 2008 29Harvey DJ(122) 2008 161

Hashiguchi K(123) 2010 13

Helmstaedter C(124) 2002 107

Helmstaedter C(125) 1996 144Hemb, M(126) 2013 55

Hermann B(127) 1999 30Hilz MJ(128) 2003 16Hlobil U(129) 2008 40

Holloway KL(130) 1995 28

Holmes MD(131) 2003 25

Holmes MD(132) 2000 23Holmes MD(133) 1996 28Ipekdal HI(134) 2010 7Jack CR Jr (135) 1995 46Jacob A(136) 2003 50Jan MM(137) 2001 29Janszky J(138) 2005 171Janszky J(139) 2005 16Janszky J(140) 2003 133Jardim AP(141) 2012 66Jeelani NU(142) 2010 105Jeha LE(143) 2006 266Jehi LE (144) 2012 312Jenssen S(145) 2006 16Jeong SW(146) 2005 227Jeong SW(147) 1999 93Jones JE(148) 2002 61Joo EY(149) 2005 28Joo EY(150) 2005 68Jooma R(151) 1995 70Jung WY(152) 1999 31Junna MR(153) 2013 400Kamida T(154) 2007 6Kanner AM(155) 2009 100Kanner AM(156) 1995 24Karadas O(157) 2011 10Kasper BS(158) 2004 59Keary TA(159) 2007 217Kelemen A(160) 2006 94Kelemen A(161) 2010 57Keller SS(162) 2007 7Kellett MW(163) 1997 45Kelley K(164) 2005 48

Killgore WD(165) 1999 8

Kilpatrick C(166) 1999 56

Kilpatrick C(167) 1997 36Kim CH(168) 2007 85

Kim MA(169) 2006 29Kim YD(170) 2005 88King JT Jr.(171) 1997 34

Kinsella DW(172) 2012 159

Kipervasser S(173) 2007 26

Kobayashi E(174) 2003 14Kohler CG(175) 2001 58Kotagal P(176) 1995 31Kovac S(177) 2010 101Kuba R(178) 2011 20Kubu CS(179) 2000 10Kutlu G(180) 2005 48

Kuzniecky R(181) 1999 40Kwan P(182) 2010 69

Labiner DM(183) 2002 83

Lackmayer K(184) 2013 9Lacruz ME(185) 2004 91Lah S(186) 2004 30Lah S(187) 2008 15

Lambert MV(188) 2003 10

Lancman ME(189) 1998 108Langfitt JT(190) 1996 59Langfitt JT(191) 2007 58Lee GP(192) 1995 25Lee SK(193) 2002 95Lee SK(194) 2000 109Lee SY(195) 2008 171Lee SY(196) 2006 51Lee YJ(197) 2010 33

Leeman BA(198) 2009 14Leijten FS(199) 2005 80Li LM(200) 2000 21Liang S(201) 2010 25Liang S(202) 2010 30Liew CJ(203) 2009 9Lin TW(204) 2007 24

Lineweaver TT(205) 2006 87

LoPinto-Khoury C(206) 2012 193

Lowe AJ(207) 2004 50Lowe NM(208) 2010 76Luther N(209) 2011 16Maganti R(210) 2003 31Maher J(211) 1998 93

Marchetti RL(212) 2003 6

Markand ON(213) 2000 53Martin R(214) 2006 50Martin RC(215) 1998 101

McClelland S(216) 2006 12

McDonald, CR(217) 2010 7

McIntosh AM(218) 2005 321



Mckhann GM(221) 2000 140

Mclachlan RS(222) 1997 51Mikati MA(223) 2006 20Mintzer S(224) 2004 4Moran M(225) 2005 30Morino M(226) 2006 17Moss K(227) 2009 27Murphy M(228) 2010 124Naga AA(229) 2004 10

Newberg AB(230) 2000 80Nilsson D(231) 2004 34Noppeney U(232) 2005 16

Noulhiane M(233) 2007 22O'Brien TJ(234) 2002 117Oddo, S(235) 2012 35Oertel J(236) 2004 59Oertel J(237) 2005 30

Olejniczak PW(238) 1996 22Paglioli E(239) 2006 80Paglioli E(240) 2004 79

Paparrigopoulos T(241) 2008 35Pataraia E(242) 2005 12Pauli E(243) 1999 42

Persson H(244) 2006 21Potter JL(245) 2009 41

Powell HWR(246) 2008 15

Powell HWR(247) 2008 7Prasad A(248) 2003 36

Prevedello DM(249) 2000 84Quarato PP(250) 2005 86

Quirico-Santos(251) 2013 10Rabin ML(252) 2004 35

Radhakrishnan A(253) 2011 12

Radhakrishnan K(254) 2003 175Ramesha K(255) 2012 50Ramesha K(256) 2011 492Ramos E(257) 2009 105Rathore C(258) 2011 262Rathore C(259) 2011 310Rausch R(260) 2003 44Ray A(261) 2002 13Reeves AL(262) 1997 134

Richardson MP(263) 2004 10Rose KJ(264) 1996 56Roubina S(265) 1997 45

Sabsevitz DS(266) 2001 21Sagher O(267) 2012 51Sainju RK(268) 2012 32

Sakamoto S(269) 2009 10Salanova V(270) 2005 262Salanova V(271) 2002 215Salanova V(272) 2004 37Salanova V(273) 1998 38Salzberg M(274) 2006 24

San-Juan D(275) 2011 39Sawrie SM(276) 1998 141Schefft BK(277) 2003 52

Schijns OEMG(278) 2011 58Schramm J(279) 2011 74Schramm J(280) 2001 11Schuh LA(281) 2000 40

Schuh LA(282) 1998 102Schulz R(283) 2005 3

Schwartz TH(284) 1997 29Schwarz M(285) 2009 58Serafini A(286) 2012 11Setoain X(287) 2004 38Seymour N(288) 2011 291Shah J(289) 2006 8Shamim S(290) 2009 30Shaw P(291) 2004 44Shih YH(292) 2003 217Shon YM(293) 2010 10Siegel AM(294) 2008 75Silander C(295) 1997 62Sindou M(296) 2006 100Sirven JI(297) 1997 15Smith AP(298) 2011 21Smith ML(299) 2011 34So EL(300) 1997 184Song JK(301) 2003 5Sperling MR(302) 1996 89Sperling MR(303) 1995 86Sperling MR(304) 1999 293

Srikijvilaikul T(305) 2003 41

Srikijvilaikul T(306) 2011 200Staack AM(307) 2011 17Stavem K(308) 2004 63Stroup E(309) 2003 132Suhy J(310) 2002 15Swartz BE(311) 1998 4Sylaja PN(312) 2004 17Tanaka T(313) 1999 10Tanriverdi T(314) 2010 123

Tatum WO 4th(315) 2008 39Tezer FI(316) 2004 48Tezer FI(317) 2011 3Tezer FI(318) 2008 109Thivard L(319) 2007 20Uijl SG(320) 2008 484Vale FL(321) 2012 86Velasco TR(322) 2006 33

Vermathen P(323) 2002 10Vinton AB(324) 2007 26

Voltzenlogel V(325) 2007 22

Walz R(326) 2003 98

Weinand ME(327) 2007 34

Weinand ME(328) 2001 48Wheelock I(329) 1998 79Wiebe S(330) 2001 36

Wieshmann UC(331) 2008 76Wilson SJ(332) 2001 90Wilson SJ(333) 1999 100Wilson SJ(334) 1998 68

Winston GP(335) 2012 20Wisniewski I(336) 2011 22Wong CH(337) 2010 64Wong CY(338) 1996 17Wong, S(339) 2009 23Wrench JM(340) 2004 43Wrench JM(341) 2011 38Wyler AR(342) 1995 70Yen DJ(343) 2006 16Yogarajah M(344) 2010 46Yogarajah M(345) 2009 21York MK(346) 2003 149Yu HY(347) 2010 202Yu HY(348) 2010 77Yu HY(349) 2009 205Yucus, C(350) 2007 23

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