antiviral drugs. mechanism of action picornaviruses eg, polioviruses, cold viruses block attachment...
TRANSCRIPT
Antiviral Drugs
Mechanism of Action
Attachment antagonists
arildone
Block attachment molecule on host cell or pathogen
Picornaviruses eg, polioviruses, cold viruses
Inhibit viral uncoating
Amantadine, rimantadine
Prevents viral uncoating
Influenza A virus
Mechanism of Action (cont.)
Inhibit nucleic acid synthesis
* Acyclovir
* Ganciclovir
* Ribavirin
Phosphorylation by virus encoded protein kinase activates the drug to inhibit DNA & RNA synthesis
Herpes, Epstein Barr, CMV, Varicella
RSV, HCV, Influenza A, hemorrhagic fever viruses
Mechanism of Action (cont.)
Inhibit nucleic acid synthesis
* Adenosine arabinoside
*Nucleoside analogs (azidothymidine
Phosphorylation by cell encoded protein kinase activates the drug to inhibit DNA synthesis
Herpes virus
HIV
Nucleoside analogues
Mechanism of Action (cont.)
Inhibit viral proteins
* Protease inhibitors blocks the active HIV site