antifungal drugs by dr.mohamed abd almoneim attia
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Antifungal drugsAntifungal drugs
ByDr.Mohamed Abd AlMoneim
Attia
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Fungal InfectionsFungal Infections Develop due to a loss of mechanical barriers
(i.e. burns, major surgery) or immunodeficiency (chemotherapy, organ transplant, AIDS)
fungal infections may be superficial or systemic
Fungi possess different ribosomes, cell wall components, and discrete nuclear membrane
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Bacteria FungiBacteria FungiNucleus no yesRibosomes 70S 80SCell Wall Peptidoglycan
ChitinMembrane No sterols
Ergosterol
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Fungal PathogensFungal Pathogens
Systemic Infections–Opportunistic pathogens
» Candida albicans» Cryptococcus neoformans» Aspergillus»Pneumocystis carinii
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Fungal PathogensFungal Pathogens
Systemic Infections– – Blastomyces dermatitidis – Histoplasma capsulatum– Parracoccidiodes
brasiliensis
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Fungal PathogensFungal Pathogens
Superficial Infections– Dermatophytes– Candida albicans
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Antifungal drugsAntifungal drugs
Drugs for systemic infections– Polyene Antibiotics– Imidazole Antifungal Drugs– Flucytosine
Drugs for superficial infections– Polyenes, Imidazoles and – Griseofulvin– Naftifine
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Polyene AntibioticsPolyene Antibiotics Polyenes bind to sterols - selectivity is poor. Clinical Uses
– Amphotericin B: systemic fungal infections – Nystatin: topical treatment of skin, oral and
intestinal Candida infections – Candicidin: topical treatment of vaginal
candidiasis. Adverse Reactions (systemic use)
– Fever,Fever, gastrointestinal distress, cardiotoxicity, hemolytic anemia, leukopenia, hepatotoxicity, nephrotoxicitynephrotoxicity.
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KetoconazoleKetoconazole
Mechanisms of action (we think)– blocks synthesis of ergosterol
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Clinical Uses - – Systemic and mucocutaneous infections. – Prevention of Candida infection in immune
suppressed patients. Adverse Reactions
– Mild side effects: GI distress and pruritus – Serious side effects:
»Hepatic toxicity - The drug must be discontinued if The drug must be discontinued if hepatitis occurs.hepatitis occurs.
»Gynecomastia - inhibition of testosterone synthesis
KetoconazoleKetoconazole
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Other Imidazole AntifungalsOther Imidazole Antifungals Miconazole- topical treatment of dermatophyte
infections and treatment of vaginal candidiasis. Clotrimazole - topical treatment of cutaneous
and vaginal infections.
Itraconazole - wider spectrum of activity than ketoconazole and fewer adverse effects. Drug of choice for several systemic infections.
Fluconazole - Cryptococcus (HIV+)
Triazole AntifungalsTriazole Antifungals
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Clinical Uses (limited): – Combined with amphotericin B - systemic
Cryptococcus and Candida infections. Adverse Reactions:
– Bone marrow depression - leukopenia and thrombocytopenia
– Gastrointestinal distress– Reversible hepatotoxicity
FlucytosineFlucytosine
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GriseofulvinGriseofulvin
Nucleus
Centrosome
GG GG
GG
GG
Microtubules
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GriseofulvinGriseofulvin Binds to keratin and reaches high
concentrations in the keratinized cells of the skin and the hair.
Clinical Uses:– Dermatophytes - Trichophyton, Epidermophyton
and Microsporum. Adverse Reactions:
– Temporary headache is common.– Nervous system - mental confusion, fatigue, visual
impairment.– Gastrointestinal distress
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Mucocutaneous Antifungals
Mucocutaneous Antifungals
Griseofulvin– enters fungal cells by an energy-
dependent process– interacts with the microtubules within
the fungus to disrupt the mitotic spindle and inhibit mitosis
– resistance due to lack of energy-dependent uptake system
– toxicities include allergic syndrome and hepatitis
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Naftifine Naftifine
Broad spectrum, fungicidal– inhibits squalene epoxidase– causes buildup of intracellular squalene – decreases ergosterol synthesis
Clinical Uses: – Dermatophytes (tinea cruris & tinea
corporis), Candida. Can cause local irritation.
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