Updated June 7, 2016

CURRICULUM VITAE

Mohamed Al-Shabrawey MD, Ph.D

Associate Professor

UNIVERSITY ADDRESS

Department of Oral Biology and Anatomy, Dental College of Georgia (DCG)

Augusta University 1120 15th Street, CB2602 Augusta, GA 30912 Phone: (706)-721-4278 Email: malshabrawey@augusta.edu

PERSONAL INFORMATION

Home Address: 623 Emerald Crossing, Evans-GA, 30809-USA Home Telephone: (706)294-2411 Citizenship: USA

EDUCATION AND TRAINING

2002-2006 Post-doctoral fellow in Vascular Biology Center; Medical College of Georgia, Augusta, USA

1995-1999 Ph.D in Anatomical Sciences, Joint Supervision Program between Faculty of Medicine, Mansoura University, Egypt and Medical College of Georgia, Georgia, USA (Mentor. Prof. Ruth B Caldwell).

1991-1994 M.Sc. in Anatomical Sciences, Faculty of Medicine, Mansoura University, Egypt.

1990-1991 General Practitioner in Military Clinics, Egypt.

1989-1990 Clinical Internship, Mansoura University Hospital, Egypt

1982-1988 MBBCH (MD), Mansoura Faculty of Medicine, Egypt

CERTIFICATION & LICENSURE

2011-2012 Teaching Scholar Fellow, Educational Innovative Institute, Georgia Health and

Science University (GHSU)

03/01/1990 – Full Unlimited Medical Licensure of Egypt

06/16/2005 Educational Commission for Foreign Medical Graduates (ECFMG) Certificate (0-

656-398-5).

04/25/2005 United States Medical Licensure Examination Clinical Skills Assessment

03/28/2005 United States Medical Licensure Examination Step 2

04/13/2004 United States Medical Licensure Examination Step 1

PROFESSIONAL EXPERIENCE

1- Academic Appointment

2013-Present Associate Professor of Oral Biology, DCG, with joint faculty appointment in Cellular Biology and Anatomy, Medical College of Georgia (MCG), Augusta University, USA

2012-Present

Director of Applied Anatomy of Head and Neck and Neuroscience, Dental College of Georgia, Augusta University, USA

2012-Present

Associate Professor of Oral Biology and Anatomy, DCG, Augusta University, USA

2012-Present Associate Professor, College of Graduate Studies, Augusta University, USA

2008-Present

Associate Member, Vascular Biology Center, Medical College of Georgia, Augusta University, USA

2008-Present Affiliate Member at Culver Vision discovery Institute, Augusta University, USA

2008-Present Assistant Professor with joint faculty appointment in Ophthalmology, Medical College of Georgia, Augusta University

2007-2012 Assistant Professor, College of Graduate Studies, GHSU, USA

2006-2012 Assistant Professor of Oral Biology and Anatomy, College of Dental Medicine CDM, Georgia Regents University (GRU), USA

2002-2006 Postdoctoral Fellow, Vascular Biology Center, Medical College of Georgia, Augusta, USA

1999-2007

Instructor of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Egypt

1996-1998 Research Fellow, Vascular Biology Center and Cellular Biology and Anatomy-Medical College of Georgia, USA

1994-1999-

Assistant Instructor of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Egypt

1992-1994 Demonstrator of Gross Anatomy, Faculty of Medicine, Mansoura University, Egypt

2- International Appointment

3. Administrative Responsibilities/Appointments

2015-Present Professor of Anatomy, Faculty of Medicine, Mansoura University, Egypt

2007-2015 Assistant Professor of Anatomy, Faculty of Medicine, Mansoura University, Egypt

2009-Present Elected Fellow of the European Association for Preventive, Predictive and

Personalized Medicine (EPMA)

09/01/2009 Assistant Professor, King Saud University, Ophthalmology, Riyadh, Saudi Arabia (Dr. Nasser Al-Rasheed Research Chair)

A. Grant Reviewer Positions

B. Journal Editorial Board/Editor Positions

2014-2015 Lead Guest Editor in BioMed Research International Journal, leading a Special issue on “Diabetic Retinopathy: Mechanism, Diagnosis, Prevention, and Treatment”.

2011-2012 Guest Editor in Journal of Experimental Diabetes Research. A Special issue on "New Developments in the Pathophysiology and Management of Diabetic Retinopathy”

2013 International Advisory Editorial Board Member, Saudi Journal of Biological Sciences

2014-Present Editorial Board member of Austin J. Clinical Ophthalmology

2014- Editorial Board member of HSOA Journal of Ophthalmology and Clinical Research

C. Scientific Meeting Organization/Modulator

05/04/2015 Organizer/chair of a special interest group (SIG) session entitled “Lipid metabolites in ischemic retinopathies: What we learned so far”, Association for Research in Vision and Ophthalmology, Denver, Colorado, USA

06/14/ 2014 Moderator of American Diabetes Association, 74th Scientific Sessions. The Guided Audio Poster Tour titled “Putting the Function Back into the Dysfunctional Retina”

2013-2014 Abstracts evaluating reviewer, American Diabetes Association, 74th Scientific meeting.

2009-2010 Organizer/chair of an international symposium on “Diabetic Retinopathy from Bedside to Bench”, King Saud University, Saudi Arabia.

D. AD-HOC JOURNAL REFEREEING

1) Diabetes

2016

2011-Present

American Diabetes Association

Expert Reviewer for Scientist Development Grant, Innovative Research, Postdoctoral and Predoctoral Fellowship, American Heart Association (AHA)

2011-Present Research Grant Reviewer for Diabetes-UK

2011-Present Research Grant Reviewer for French National Research Agency (Agence

Nationale Dela Recherche)

2014 Research Grant Reviewer for Fight for Sight-UK 2012 Research Grant Reviewer for American Institute of Biological Sciences 2014 Research Grant Reviewer for Medical Research Council (MRC)-UK 2013 Research Grant Reviewer for Wellcome Trust 2012 Research Grant Reviewer for the National Center for Replacement, Refinement

and Reduction of Animal in Research (NC3Rs

2) Investigative Ophthalmology and vision Science (IOVS) 3) PLOS One 4) British J. Pharmacology 5) British J. Ophthalmology 6) Cell Biology International 7) Experimental Eye Research 8) Current Eye Research 9) Clinical and Experimental Ophthalmology 10) Molecular Vision 11) Ophthalmology Research 12) Vascular Pharmacology 13) American Journal of Physiology

4. COMMITTEE ASSIGNMENTS

2016

2015-Present

Chair of Pre-tenure Committee, DCG, AU

Chair of Anatomy Search Committee, DCG, AU

2015 Search Committee member (Department of Peridonotology), DCG, AU

2014 Grand Administrator Search Committee, DCG, AU

2013 Dean Search Committee member, College of Dental Medicine (CDM), Georgia Regents University, GRU

2012-Present Student Academic Review (SARC) CDM, GRU

2013-Present Promotion and Tenure Committee, School of Allied Health, GRU 2012-Present Promotion and Tenure Committee, CDM, GRU

2010 Chair of Anatomy Faculty Search committee, CDM, GRU 2012-2013 Research Advisory Committee, CDM, GRU

2008 Curriculum Committee, CDM, GRU 2008 Faculty Search Committee member (Oral Biology/Pharmacology)

5. RESEARCH AND TRAINING GRANTS AWARDED

A-ongoing research support

1) R01EY023315 04/01/2013-03/31/2018 Total: $1,782,000

NIH/ National Eye Institute

Title: Role of lipoxygenase pathway in early microvascular dysfunction during diabetic retinopathy Role: Principal Investigator 30% effort

2) K12 HD 085817 07/01/15-06-30/20 Total:$1,575,000.00

NIH/ National Institute of Child Health and Human Development Title: GRU Women’s Reproductive Health Research (WRHR) Career Development Center

Role: Mentor (PI: Diamond M)

3) 16SDG30700016 07/01/2016-06/30/2019

Total: $ 231,000

Scientist Development Grant (American Heart Association) Title: Hyperhomocysteinemia; Potential Role in Diabetic Retinopathy Role: Co-Investigator (PI: Amany Tawfik) 5% effort

B-Pending

1) R01 01/01/2017-12/31/2022 Total: $1,900,000

NIH/ National Eye Institute

Title: BMP/smad pathway; a novel player in the development of diabetic retinopathy

Role: Principal Investigator 25% effort

2) ADA 01/01/2017-12/31/2020 Total: $330,000

American Diabetes Association Title: Role of BMP2/smad pathway in the development of microvascular dysfunction in diabetic retinopathy Role: Principal Investigator 13% effort

3) R01-3900914 10/01/2016-09/30/2021 Total: $1,800,000

NIH/ National Eye Institute Title: Retinal Endothelial Cell Barrier Dysfunction in Hyperhomocysteinemia; Potential Role in Diabetic Retinopathy Role: Co-Investigator PI: Amany Tawfik 10% effort

C. Completed Research Support

1) NPRP 4-1046-3-284 04/01/2012 – 03/31/2015 Total:$996,000;

Qatar National Research Fund (QNRF)

Title: Lipoxygenase pathway in retinal angiogenesis

Role: Principal Investigator 15% effort

2) VDI04750039 12/01/2014-06/30/2015 Total: $12,500.0

Culver Vision Discovery Institute

Title: 12/15-LOX and Dietary Supplement Therapy: Shaping Endogenous Protection in Traumatic Optic Neuropathy

Role: Principal Investigator 5% effort

3) VDI 07450031 03/01/2013-02/28/2014 Total: $14,000.

Culver Vision Discovery Institute Title: Role of caspase-14 in ischemic retinopathy

Role: Principal Investigator 5% effort

4) SDG0735032N 07/01/2007 – 05/31/2012 Total: $260,000

American Heart Association National / Scientific Development Grant Title: Mechanism of NADPH Oxidase-Mediated Vascular Inflammation in Diabetes: Role of 12-Lipoxygenase Role: Principal Investigator

5) Institutional Bridge Fund 03/01/2012 – 02/28/2013 Total: $50,000

Title: Mechanism of retinal early microvascular dysfunction in diabetic retinopathy Role: Principal Investigator

6) Saudi Cultural Bureau (2007-2012) Total: $ 120,000

Title: Interaction between osteogenic and angiogenic factors during bone healing

Role: Mentor for a Ph.D student (Sara Akeel) 7) VDI002010 10/01/2010 – 09/30/2011 Total: $25,000

Intramural Research Grant/ Vision Discover Institute, Georgia Health Sciences University

Title: 12-lipoxygenase pathway of arachidonic acid metabolism in ischemic retinopathy

Role: Principal Investigator

8) PSRP (Pilot Grant) 00022794 12/1/2008-11/30/2009 Total: $25,000

Title: Role of 12-Lipoxygenase in Pathological Retinal Neovascularization Role: Principal Investigator

AWARDS/HONORS

2014 Research Excellence Award, Qatar Foundation Annual Research Conference

2013 National Eye Institute Research Award (R01)

2012 Educational Innovation Institute Associate Membership (EII-GHSU)

2011 Qatar National Research Fund Award

2010 Vision Discovery Institute Award, Medical College of Georgia (GHSU)

2010

Certificate of appreciation from the Department of Ophthalmology, King Saud University, Saudi Arabia, for organizing an international symposium (Diabetic Retinopathy from Bedside to Bench) and for contribution to establishing a retina research unit.

2008 Pilot Study Research Program (PSRP) (GHSU) 2007 American Heart Association Scientist Development Award 2005 President’s Award (ARVO Excellence in Research) 2005 Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship Award

2004 National Eye Institute (NEI) Travel award 2004 ARVO Postdoctoral Fellowship Award 2003 Fight for Sight Postdoctoral Fellowship Award 2001 Mansoura University Research Award 1996 Egyptian Government Ph.D Scholarship 1992 Mansoura University Scholarship for M.Sc

1989 Mansoura University Honor of Academic Excellence in Medical School (1983- 1988).

Awards by the Mentees

05/2016 Mr. and Mrs. Richards Travel award for ARVO meeting Seattle, WAS, USA (Khaled ElMasry, PhD Student).

03/2016 First Prize Winner of Poster Presentation Competition Graduate Research Day, Augusta University (Khaled ElMasry, PhD Student).

08/2015 ARVO Travel Scholarship for Diabetic Retinopathy Conference, Bethesda, MD (Ahmed Ibrahim, PhD Post doc).

08/2015 ARVO Travel Scholarship for Diabetic Retinopathy Conference, Bethesda, MD (Fang Wang, MD Post doc).

05/2015 Hot Topic Oral-Presentation Award, ARVO Meeting, Denver, CO, USA (Ahmed Ibrahim, PhD Post doc).

05/2014 Mr. and Mrs. Richards Travel award for ARVO meeting Orlando, FL, USA (Ahmed Ibrahim, PhD Post doc).

09/2014 Southern Translational Education and Research Conference (STaR), Travel Award, Augusta, GA, USA (Ahmed Ibrahim, PhD Post doc).

05/2014 Dean Funds’ of Summer Research, Georgia Regents University (Farid Khan, MD Student).

05/2012 ARVO Travel Scholarship (Karishma Choksi, Msc Student).

03/2011 First Prize Winner of Poster Presentation Competition Graduate Research Day, GHSU (Sara Akeel, PhD Student).

03/2011 American Anatomical Association Travel Award (Sara Akeel, PhD Student).

COMMITTEE MEMBERSHIP IN SCIENTIFIC AND PROFESSIONAL SOCIETIES

2015-Present American Society for Biochemistry and Molecular Biology (ASBMB)

2002-Present Association for Research in Vision and Ophthalmology (ARVO)

2005-Present American Diabetes Association (ADA)

2007-Present American Heart Association (AHA)

2007-Present American Stroke Association

2008-Present American Association of Anatomist 2008-Present American Dental Education Association (ADEA) 1990-Present Egyptian Physician Syndicate 1990-2002 Egyptian Society of Anatomy

PRESENTATIONS AT NATIONAL, REGIONAL AND INTERNATIONAL MEETINGS

I. Invited Speaker and Lectures

1. Invited delegate “Arab Expatriate Scientists (AES) and The Annual Research Conference (ARC-2016)”. Doha, Qatar, March 21-23, 2016.

2. Invited Speaker “Bioactive Lipids and Early inflammatory Response in diabetic Retinopathy The European Association for Vision and Eye Research (EVER); October 7-10, 2015, Nice, France.

3. Invited Speaker “12/15-Lipoxygenase and Diabetic Retinopathy. ARVO, Denver, 2015.

4. Invited Speaker “Novel Pathways in the development of diabetic retinopathy. Qatar University, Doha, Qatar, November 17 2014

5. Invited Speaker “Role of Inflammation in diabetic retinopathy”, Louisiana State University, New Orleans, September 16, 2013

6. Invited Speaker “Early Inflammatory Response in Diabetic Retinopathy”, University of Texas, Southwestern Medical Center, Dallas, August 26, 2013

7. Invited Lecture “Mechanism of Microvascular Dysfunction in Diabetic Retinopathy”, Mansoura University, College of Medicine, Egypt, June 20, 2013

8. Invited Speaker “Microvascular Dysfunction in Diabetic Retinopathy”; New Regulators. Oklahmoa University, May 15, 2013

9. Invited Speaker “Lipoxygenase Pathway as a Therapeutic Target in Diabetic Retinopathy. International symposium of Ocular Pharmacology and therapeutic (ISOPT), Paris-France, March 10, 2013

10. Invited Speaker “Lipoxygenase pathway in diabetic retinopathy”, Indiana University, School of Optometry. December 11, 2012.

11. Invited Speaker “Contribution of 12/15 lipoxygenase pathway to ischemic retinopathy. The University of Texas Health Science Center at Houston. December 20, 2011

12. Invited Lecture “Making Anatomy Relevant to Dental Practice”, The University of Texas Health Science Center at Houston. December 20, 2011

13. Invited Lecture “Novel Therapeutic Targets in Diabetic Retinopathy, Our Bench Experience”. Ophthalmology Center, Mansoura University, Egypt. June 2, 2011.

14. Invited Speaker “Contribution of NADPH oxidase to vascular injury in diabetic retinopathy” Department of Pathology, University of Wisconsin, Madison-USA, January 20, 2010.

15. Invited Speaker “Oxidative Stress in Diabetic Retinopathy. 33rd Ophthalmology symposium (Diabetic retinopathy from basic science to clinical practice)-King Saud University-Riyadh-Saudi Arabia-May 17, 2010

16. Invited Speaker “Role of Eicosanoids in Diabetic Retinopathy”, 33rd Ophthalmology Symposium (Diabetic retinopathy from basic science to clinical practice)-King Saud University-Riyadh-Saudi Arabia-May 18, 2010

17. Invited Speaker “NEW Therapeutic Targets in Diabetic Retinopathy”, King Khalid Eye Specialty Hospital, Riyadh, Saudi Arabia March 22, 2010

18. Invited Speaker “12-Lipoxygenase: A new Target for Therapeutic Intervention in Pathological Retinal Neovascularization”. Saudi Ophthalmology Society, Riyadh, Saudi Arabia Feburary, 2010.

19. Invited Speaker “Contribution of reactive oxygen species to diabetic retinopathy”, 69th American diabetes Association, New Orleans, June 8, 2009, (Webcast presentation).

20. Invited Speaker “NADPH Oxidase a Key Mediator of Diabetic Retinopathy. Vascular Biology Center, Medical College of Georgia, September 27, 2006.

21. Invited Speaker “NADPH Oxidase; A New Target for Anti-angiogenic Therapy”, Lexicon Genetic; Woodlands-TX, March 10, 2004.

II. Oral Presentations

22. Tawfik A, Ibrahim AS, El-Sherbiny NM, Smith SB, Al-Shabrawey M. Hyperhomocysteinemia Disrupts Retinal Pigment Epithelial Structure and Function with Features of Age-Related Macular Degeneration. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 2, 2016; 1403, Seattle, Washington, USA, (Hot Topic).

23. Ibrahim AS, Saleh H, Hussein KA, Fang Wang, Al-Shabrawey M. Profile of Circulating Arachidonic Acid Derived Eicosanoids in Mouse Model of Diabetic Retinopathy. Diabetic

Retinopathy meeting: Battling the Global Epidemic; August 26, 2015; Bethesda, Maryland, USA. (Travel Award).

24. Ibrahim AS, Hussein KA, Tawfik A, Rizk N, Smith SB, Al-Shabrawey M. 12/15-Lipoxygenase Gene Deletion Attenuates Blood-Retinal Barrier Dysfunction During Diabetic Retinopathy: Contribution of ER Stress. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 7, 2015; Denver, Colorado, USA, (Hot Topic).

25. Al-Shabrawey M, Ibrahim AS, Beasley S, Wang F, and Tawfik A. Bioactive Lipids and Early inflammatory Response in diabetic Retinopathy The European Association for Vision and Eye Research (EVER); October 7-10, 2015, Nice, France.

26. Al-Shabrawey M, Ibrahim AS, Tawfik A, El-Shafey S, and Rizk N. 12/15-lipoxygenase: A Novel Therapeutic Target in Diabetic Retinopathy. International Qatar Annual Research Conference (ARC), November 16, 2014, Doha, Qatar, (Excellence Award).

27. Ibrahim AS, Elshafey S, Hussein KA, Smith SB, Tawfik A, and Al-Shabrawey M. 12/15-Lipoxygenase Derived Hydroxyeicosatertraenoic Acids are Early Inducer of Vascular Permeability in Diabetic Retinopathy via NADPH oxidase. 49th Annual South Eastern Regional Lipid Conference (SERLC), November 5-7, 2014; Cashiers, North Carolina, USA.

28. Al-Shabrawey M, Ibrahim AS, Elshafey S, Rizk N, Smith SB, Duh EJ, and Tawfik A. Targeting Retinal 12/15-Lipoxygenase Signaling Pathway by Pigment Epithelium-Derived Factor: A Novel Mechanism for Treating Diabetic Retinopathy. 49th Annual South Eastern Regional Lipid Conference (SERLC), November 5-7, 2014; Cashiers, North Carolina, USA.

29. Ibrahim AS, and Al-Shabrawey M. Retinal Endothelial Cell Activation by 12/15-Hydroxyeicosatetreanoic acids (HETEs): Evolving role of NADPH oxidase. Georgia Regents University, Post-doctoral Association and Shared Resources Symposium in 30th Annual Graduate Research Day, March 21, 2014; Augusta, GA, USA.

30. Ibrahim AS, Elshafey S, and Al-Shabrawey M. Evolving role of 12/15-Lipoxygenase derived lipid metabolites in the induction of retinal endothelial dysfunction. 6th Annual Culver Vision Discovery Institute Scientific Retreat (VDI), February 28th, 2014; Augusta, GA, USA.

III. Poster Presentations:

31. Akeel S, Hussein K, El-awady A, Elsalanty M, Sharawy M, Al-Shabrawey M. rhBMP2 Enhances Bone and Vessel Formation In Critical Size Defect Independent of VEGF. American Association of Dental Research (AADR) Annual Meeting & Exhibition, Mar 17, 2016, Los Angeles, CA, USA.

32. Al-Shabrawey M Ibrahim AS, El masry K, Hussein K, Saleh H, Elsherbiny N, Kondrikova G, Hill D, Sheibani N, and Tawfik A. Endothelial 12/15-lipoxygenase-derived eicosanoids promote retinal microvascular dysfunction in diabetic retinopathy. 16th International Winter Eicosanoid Conference, March 13-16, 2016, Baltimore, MD, USA.

33. Ibrahim AS, Saleh HM, Beasly S, Hassan H, Tawfik A, Al-Shabrawey M. Differential Profiles of Circulating Eicosanoids Derived From Arachidonic Acid in Mouse Models of Type 1 and Type 2 Diabetes. 16th International Winter Eicosanoid Conference, March 13-16, 2016, Baltimore, MD, USA.

34. El Masry K, and Al-Shabrawey M. 12/15-Lipoxygenase Derived Eicosanoids Induced Endoplasmic Reticulum Stress; Potential Mechanism in The Development Of Diabetic Retinopathy. 32th Annual Graduate Research Day, March 11, 2016; Augusta, GA, USA. (Excellence Award).

35. Ibrahim AS, and Al-Shabrawey M. Altered Profiles of Circulating Bioactive Mediators Derived From Arachidonic Acid in Mouse Models Of Type 1 and Type 2 Diabetes. Post-doctoral Association and Shared Resources Symposium in 32th Annual Graduate Research Day, March 11, 2016; Augusta, GA, USA.

36. Elmasry K, Ibrahim AS, Hussein KA, Saleh HM, Hassan H, El-Sherbiny NM, Al-Shabrawey M. 12/15-Lipoxygenase Derived Eicosanoids Induce Endoplasmic Reticulum Stress in Human Rretinal Endothelial Cells: Potential Mechanism In The Development Of Diabetic Retinopathy. 16th International Winter Eicosanoid Conference, March 13-16, 2016, Baltimore, MD, USA.

37. Ibrahim AS, Saleh H, Hussein K , Baban B, Sheibani N, Al-Shabrawey M. Differential Activity of Systemic and Retinal 12/15-Lipoxygenases in a Mouse Model of Diabetes. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 2, 2016; 1756- D0152, Seattle, Washington, USA.

38. Sharma I, Ibrahim AS, Saleh HM, Rizwan S, Liou GI, Al-Shabrawey M, Tawfik A. Elevated homocysteine in the vitreous of diabetic patients and blood of type 1 and 2 diabetic animal models; Potential role of homocysteine in blood retinal barrier dysfunction. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 3, 2016; 3218-C0018, Seattle, Washington, USA.

39. Hussein KA, Wang F, Ibrahim AS, Saleh HM, Elmasry K, El-Sherbiny NM, Yu P, Al-Shabrawey M. BMP2 and 4 Contribute to Retinal Endothelial Cell Barrier Dysfunction in Diabetic Retinopathy: Role of p38 MAPK Pathway. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 4, 2016; 5448 - B0188, Seattle, Washington, USA.

40. Saleh HM, Hussein KA, Ibrahim AS, Elmasry K, El-Sherbiny NM, Fulton D, Al-Shabrawey M. NOX4 Stabilizes Barrier Function of Human Retinal Endothelial Cells and Retinal Pigment Epithelial Cells. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 3, 2016; 3216 - C0016, Seattle, Washington, USA.

41. Elmasry K, Hussein KA, Saleh HM, Ibrahim AS, El-Sherbiny NM, Helwa I, Liu Y, Al-Shabrawey M. Exosomes Released From Human Retinal Endothelial Cells Upon 15-HETE Treatment or ER Stress Induction: Potential Role of Nanoparticles in Diabetic Retinopathy. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 3, 2016; 3230-C0030, Seattle, Washington, USA.

42. Gutsaeva D, Hussein K, Lamoke F, Kwok H, Solomon A, Martin P, Al-Shabrawey M, Bartoli M. Regulation of retinal blood barrier by TNF alpha convertase, ADAM17, and its implication in diabetic macular edema. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 3, 2016; 3226 - C0026, Seattle, Washington, USA.

43. Samra Y, Saleh HM, Hussein KA, El-Sherbiny NM, Ibrahim AS, Fulzele S, EL-shishtawey M, Eissa L, Al-Shabrawey M, Liou GI. Adenosine deaminase-2-induced permeability increase in HRECs is suppressed by miR-146b-3p. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 2, 2016; 5424 - B0164, Seattle, Washington, USA.

44. Fang W, Hussein KA, Ibrahim AS, Saleh H, Al-Shabrawey M. Bone Morphogenetic Proteins 2/4 and the Outer Blood Retinal Barrier Dysfunction. Diabetic Retinopathy meeting: Battling the Global Epidemic; August 26, 2015; Bethesda, Maryland, USA, (Travel Award).

45. Sharma S, Dworshak J, Markand S, Ibrahim AS, Saul A, Al-Shabrawey M, Caldwell R, Smith SB. IL-6 trans-signaling, a novel therapeutic target in diabetic retinopathy. Diabetic

Retinopathy meeting: Battling the Global Epidemic; August 26, 2015; Bethesda, Maryland, USA.

46. El Masry K, Basealy S, Ibrahim AS, Tawfik A, Smith SB, Al-Shabrawey M. Role of ER Stress and Nitric Oxide Generation in 12/15 Lipoxygenase-Mediated Retinal Microvascular Dysfunction in Diabetic Retinopathy. Diabetic Retinopathy meeting: Battling the Global Epidemic; August 26, 2015; Bethesda, Maryland, USA.

47. Ibrahim AS, Al-Shabrawey M. NADPH Oxidase Mediates the Effect of 12/15-Lipoxygenase on retinal Microvasculature function during Diabetic Retinopathy. Post-doctoral Association and Shared Resources Symposium in 31th Annual Graduate Research Day, March 21, 2015; Augusta, GA, USA.

48. Hussein K, Ibrahim AS, Yu P, Al-Shabrawey M. Inhibition of BMP/SMAD pathway attenuates high glucose-induced retinal endothelial cell hyperpermeability. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 7, 2015; Denver, Colorado, USA.

49. Tawfik A, Suchreet Mander S, Smith SB, and Al-Shabrawey M. Blood Retinal Barrier Dysfunction in Hyperhomocysteinemia. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 7, 2015; Denver, Colorado, USA.

50. Khan F, Ibrahim AS, Still A, Saul A, Hoda N and Al-Shabrawey M. Supplementing Dietary DHA Attenuates Traumatic Optic Neuropathy by Manipulating 12/15-Lipoxygenase Activity. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 7, 2015; Denver, Colorado, USA.

51. Isha Sharma I Nasser Rizk N Falel A, Al-Shabrawey M. Docosahexaenoic acid (DHA)-a novel therapeutic intervention for mitigating hypoxia induced retinal endothelial dysfunction. The Association for Research in Vision and Ophthalmology (ARVO) Meeting, May 7, 2015; Denver, Colorado, USA.

52. Ibrahim AS, Elshafey S, Sellak H, Hussein KA, El-Sherbiny M, Beasley S, Smith SB, Tawfik A, and Al-Shabrawey M. 12/15-Lipoxygenase Derived Bioactive Lipid Metabolites Mediate Microvascular Dysfunction in Diabetic Retinopathy. STaR Meeting, September 25, 2014; Augusta, Georgia, USA.

53. Ibrahim AS, Tawfik A, Elshafey S, Duh EJ, Smith SB, Al-Shabrawey M. Pro-inflammatory effect of 12/15-lipoxygenase derived lipid metabolites in retina: Role of Pigment epithelium-derived factor (PEDF) suppression. ARVO Meeting Abstracts, April 30, 2014; 55:2258, Orlando, Florida, USA.

54. Al-Shabrawey M, Ibrahim AS, El-Shafey S, Rizk N, Smith S, and Tawfik A. 12/15-Lipoxygenase Derived Eicosanoids Activate Human Retinal Endothelial Cells And Induce Diabetic Retinopathy Phenotype. 15th International Winter Eicosanoid Conference, March 9, 2014; Baltimore, Maryland, USA.

55. El-shafey S, El-Sherbiny M, Othman A, Ibrahim AS, Abdelsaid MA, Rizk N, Al-Shabrawey M. 12/15-Lipoxygenase-Derived Eicosanoids Induce Vascular Inflammation and Angiogenic Effects in Human Retinal Endothelial Cells: Role of NADPH oxidase and ER Stress. ARVO Meeting Abstracts, May, 2014; 55:5398, Orlando, FL, USA.

56. Hussein K; Choksi K; Elsherbiny M; Akeel S; Ahmed S; Nawaz M; El-Asrar A; and Al-Shabrawey M. Bone Morphogenetic Protein 2: a Potential New Player in the Pathogenesis of Diabetic Retinopathy. ARVO Meeting Abstracts, May, 2014; 55: 4930, Orlando, FL, USA.

57. Al-Shabrawey M; Abdelsaid M; Elshafey S; Ergul A; Damme J; Struyf S. Platelet Factor-4 Variant, a Novel Angiostatic Chemokine Inhibits Pathological Retinal Neovascularization in Oxygen-Induced Retinopathy Mouse Model. ARVO Meeting Abstracts, May, 2014; 55: 5407, Orlando, FL, USA.

58. Beasley S; Elsherbiny M; Megyerdi S; El-shafey S; Sheibani N; Al-Shabrawey M. Caspase-14 Expression Impairs Retinal Pigment Epithelial Cell Barrier Function. ARVO Meeting Abstracts, May, 2014; 55: 2244, Orlando, FL, USA.

59. Sobeih D; Hussein K; Said N; Motamed K; Al-Shabrawey M. Effect of SPARC deletion on retinal neovascularization and capillary drop out in mouse model of ischemic retinopathy. ARVO Meeting Abstracts, May, 2014; 55: 376, Orlando, FL, USA.

60. Tawfik A; Elshafey S; Shanmugam A; Markand S; Angara K; Al-Shabrawey M; Ganapathy V; Smith S. Alterations of retinal vasculature in cystathionine-beta-synthase heterozygous mice, a model of mild-moderate hyperhomocysteinemia (HHcy). ARVO Meeting Abstracts, May, 2014; 55: 2250, Orlando, FL, USA.

61. Al-Shabrawey M. 12/15-lipoxygenase derived lipid metabolites activate human retinal endothelial cells and induce diabetic retinopathy phenotype. Annual Research Conference, Doha, Qatar, November 2013.

62. Al-Shabrawey M; Megyerdi S; Martin P; Sheibani N; Hsu S. Caspase-14 Expression Impairs Retinal Pigment Epithelial Cell Barrier Function. ARVO Meeting Abstracts, May, 2013; 54: 1198, Seattle, Washington, USA.

63. Tawfik A; Markand S; Magyerdi S; Al-Shabrawey M; Smith S. Mechanisms of Retinal Vascular Alteration in Hyperhomocysteinemia. ARVO Meeting Abstracts, May, 2013; 54: 2463, Seattle, Washington, USA.

64. Tawfik A; Sonne S; Williams C; Al-Shabrawey M; Ganapathy V; Smith SB. Altered Retinal Vasculature in Hyperhomocysteinemic Mice. ARVO Meeting Abstracts, May, 2012; 53: 2557, Fort Lauderdale, Florida, USA.

65. Othman A; Ahmad S; Megyerdi S; Choksi K; Behzadian A; Liou GI; Maddipati K; Al-Shabrawey M. Increased Retinal Endothelial Cell Permeability By 12/15-lipoxygenase-derived Eicosanoids: A Possible Role Of NADPH Oxidase. ARVO Meeting Abstracts, May, 2012; 53: 5401, Fort Lauderdale, Florida, USA.

66. Megyerdi S; Ahmad S; Hsu S; Gurel Z; Shin E; Sheibani N; Al-Shabrawey M. Caspase-14: A Novel Caspase with Potential Role in Diabetic Retinopathy. ARVO Meeting Abstracts, May, 2012; 53: 5783, Fort Lauderdale, Florida, USA.

67. Hussein K, Helwa I, Zakhary I, Elrefai R, Al-Shabrawey M, Sharawy M. Novel Dose Dependent Positive Feedback Loop in Endothelial Cells: A Response to rhBMP2 Treatment. The FASEB Journal 2012, 26:728.3.

68. Hussein K, Elawady A, Zakhary I, Emam H, Al-Shabrawey M, Sharawy M, Elsalanty M. Endogenous up regulation of Bone Morphogenetic Protein 2 (BMP2) in response to recombinant human BMP2 application is segmental mandibular defects. The key of successful bone regeneration. The FASEB Journal 2011, 25:678.9.

69. Ahmad S; Megyerdi S; Baban B; Sheibani N; Liou GI; Al-Shabrawey M. Diabetes Increases And Activates Caspase-14 Expression In Human And Mouse Retina. ARVO Meeting Abstracts, May, 2011; 52: 3564, Fort Lauderdale, Florida, USA.

70. Al-Shabrawey M; El-Marakby A; Ahmad S; Megyerdi S; Maddipati K. Inhibition Of 12/15 Lipoxygenase Reduces Oxidative Stress And Inflammatory Cytokines In Retina Of Diabetic Mouse. ARVO Meeting Abstracts, May, 2011; 52: 4449, Fort Lauderdale, Florida, USA.

71. Akeel S; Megyerdi S; Ahmad S; Baban B; Sarthy V; Al-Shabrawey M. Up-regulation of Bone Morphogenetic Protein-2 in Retina of Patients with Diabetic Retinopathy and Mouse Model of Experimental Diabetes. ARVO Meeting Abstracts, May, 2011; 52: 5976, Fort Lauderdale, Florida, USA.

72. Akeel S, El-Awady A, El-Salanty M, Sharawy M, Al-Shabrawey M: BMP-2 induces VEGF expression in cultured human osteoblast: a possible role for reactive oxygen species and HIF-1α. The FASEB Journal 2011, 25:492.2. Experimental Biology Meeting, April 2011-Washington DC.

73. Al-Shabrawey MA, Mussell R, Tawfik A, Kahook K, El-marakby A, Sheibani N, Maddipati K. Inhibition or deletion of 12/15-lipoxygenase reduces pathological retinal neovascularization. The FASEB Journal 2011, 25:684.6. Experimental Biology Meeting, April 2011-Washington DC.

74. Elmarakby AA, Faulkner J, Al-Shabrawey M. Inhibition of 12-lipoxygenase reduces renal inflammation and damage in steptozotocin-induced diabetic mice. The FASEB Journal 2011, 25:664.13. Experimental Biology Meeting, April 2011-Washington DC.

75. Elmarakby AA, Faulkner J, Al-Shabrawey M, Wang M-H, Imig J. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. The FASEB Journal 2011, 25:664.10. Experimental Biology Meeting, April 2011-Washington DC.

76. Al-Shabrawey M; Mussell R; Tawfik A; Hsu S. Caspase 14; A Novel molecule of possible role in ischemic retinopathy. ARVO Meeting Abstracts, May, 2010; 51: 4464, Fort Lauderdale, Florida, USA.

77. Eladl M; Mussell R; Kahook K; Tawfik A; Maddipati K; Nussbaum J; Al-Shabrawey M. Increased Production of Hydroxyeicosatetraneoic Acids in Proliferative Diabetic Retinopathy and Oxygen-Induced Retinopathy: Implication In Retinal Neovascularization. ARVO Meeting Abstracts, May, 2010; 51: 5623, Fort Lauderdale, Florida, USA.

78. Mussell R, Eladl M, Nussbaum J, Honn K, Maddipati K, Sarthy V, Tawfik A, Al-Shabrawey M. 12-Lipoxygenase: A New Target for Therapeutic Intervention in Diabetic (Ischemic) Retinopathy. 69th American diabetes Association, New Orleans, June 8, 2009.

79. Kahook K; Tawfik A; Mussell R; Sarthy V; Al-Shabrawey M. Role of 12-Lipoxygenase in Pathological Retinal Neovascularization. ARVO Meeting Abstracts, May, 2009; 50: 5691, Fort Lauderdale, Florida, USA.

80. Abdelsaid M; Pillai B; Matragoon S; Prakash R; Al-shabrawey M; El-Remessy A. Early Intervention of Tyrosine Nitration Prevents Vaso-Obliteration and Neovascularization in Ischemic Retinopathy. ARVO Meeting Abstracts, May, 2009; 50: 5357, Fort Lauderdale, Florida, USA.

81. Al-Shabrawey M, Mussell R; Liou GI; Akeel S; Tawfik A. Diabetes Increases 12-Lipoxygenase Expression in Human and Mouse retinas. ARVO Meeting Abstracts, May, 2009; 50: 5370, Fort Lauderdale, Florida, USA.

82. Al-Shabrawey M; Sanders T; Tawfik A. Diabetes Suppresses Retinal Expression of PPAR; Correlation With Oxidative Stress and Vascular Inflammation. ARVO Meeting Abstracts, May, 2008; 49: 1334, Fort Lauderdale, Florida, USA.

83. Sanders T; Tawfik A; Al-Shabrawey M. Decreased PPAR γ Expression in Oxygen-Induced Retinopathy: A Possible Role for NADPH Oxidase. ARVO Meeting Abstracts, May, 2008; 49: 2627, Fort Lauderdale, Florida, USA.

84. Al-Shabrawey M; Sanders T; Caldwell R. NADPH Oxidase Regulates PPAR γ Expression In Models of Ischemic Retinopathy. ARVO Meeting Abstracts, May, 2007; 48: 4963, Fort Lauderdale, Florida, USA.

85. Rojas M; Brands M; Lee D; Bartoli M; Romero M; Al-Shabrawey M; Tsai N; Caldwell RW; Caldwell RB. Role of IL-6 in Angiotensin-Induced Expression of VEGF in the Mouse Retina. ARVO Meeting Abstracts, May, 2007; 48: 1376, Fort Lauderdale, Florida, USA.

86. Al-Shabrawey M; Rojas M; Bartoli M; El–Remessy A; Behzadian A; Miller T; Lemtalsi T; Liou GI; Caldwell RB. Preservation of the Blood Retinal Barrier (BRB) in Diabetes by Deletion of gp91phox or Inhibition of NADPH Oxidase. ARVO Meeting Abstracts, May, 2006; 47: 138, Fort Lauderdale, Florida, USA.

87. Bartoli M; Al-Shabrawey M; Platt D; Lemtalsi T; El-Remessy A; Rojas M; Caldwell RW; Behzadian A; Caldwell RB. Statin Prevents VEGF and High Glucose–Dependent STAT3 Activation and STAT3–Dependent ICAM–1 Expression in Retinal Endothelial Cells and in Diabetic Rat Retinas. ARVO Meeting Abstracts, May, 2006; 47: 1719, Fort Lauderdale, Florida, USA.

88. Khalifa Y; Al-Shabrawey M; Mian S; Ola M; Caldwell R; Liou GI. Endocannabinoid System Modulation of Glutamate Toxicity in Oxygen–Induced Retinopathy. ARVO Meeting Abstracts, May, 2006; 47: 3221, Fort Lauderdale, Florida, USA.

89. El-Remessy AB, Al-Shabrawey M, Bartoli M, Miller T, Caldwell RW, Caldwell RB. Dual role of peroxynitrite in oxygen-induced retinopathy: oxidation versus nitration. The FASEB Journal 2006, 20:A1084.

90. Al-Shabrawey M, Rojas M, Parpia A, Bartoli M, El-Remessy A, Behzadian A, Caldwell R. Deletion of Gp91phox or Inhibition of NADPH oxidase Blocks Diabetes-Induced ICAM-1 Expression and Leukocyte Adhesion and Preserves the Blood-retinal Barrier (BRB). 66th American Diabetes Association (ADA), June 2006, Washington DC.

91. Liou GI; El-Remessy A; Al-Shabrawey M; Khalifa Y; Caldwell RB. Neuroprotective and Blood–Retinal Barrier–Preserving Effects of Cannabidiol in Experimental Diabetes. ARVO Meeting Abstracts, May, 2005; 46: 450, Fort Lauderdale, Florida, USA.

92. Al-Shabrawey M, Ma G, Bartoli M, El-Remessy A, Platt D, Behzadian A, Caldwell RW, Caldwell RB. Is NADPH oxidase Activity Involved in Diabetes-Induced Retinal hyperpermeability?. 65th ADA meeting; June 2005-San Diego-CA-USA.

93. Liu E; Khalifa Y; Al-Shabrawey M; Liu S; Caldwell RB; Liou GI. Anti–Inflammatory Effects of Cannabinoids in Endotoxin–Induced Uveitis. ARVO Meeting Abstracts, May, 2005; 46: 972, Fort Lauderdale, Florida, USA.

94. Al-Shabrawey M; Bartoli M; El-Remessy A; Platt D; Behzadian A; Ma G; Caldwell RW; Caldwell RB. Simvastatin Inhibits Diabetes–Induced Retinal Vascular Hyperpermeability, Suppresses NADPH Oxidase and Preserves the Balance Between VEGF and PEDF. ARVO Meeting Abstracts, May, 2005; 46: 454, Fort Lauderdale, Florida, USA.

95. Istanboli; Al-Shabrawey M; Behzadian M; Franklin T; Lemtalsi T; Platt D; El-Remessy A; Caldwell RB; Bartoli M. Statin Treatment Is Protective for Oxygen–Induced Retinal

Microvascular Injury. ARVO Meeting Abstracts, May, 2005; 46: 466, Fort Lauderdale, Florida, USA.

96. Platt D; Bartoli M; El-Remessy A; Al-Shabrawey M; Lemtalsi T; Caldwell RB. High Glucose Increases VEGF in Bovine Retinal Endothelial Cells Via Peroxynitrite–induced Activation of Src Kinase. ARVO Meeting Abstracts, May, 2005; 46: 4195, Fort Lauderdale, Florida, USA.

97. El-Remessy A; Al-Shabrawey M; Ghaly N; Platt D; Bartoli M; Behzadian M; Motamed K; Caldwell RB. Role of Peroxynitrite in Retinal Neovascularization and VEGF Angiogenic Signaling. ARVO Meeting Abstracts, May, 2005; 46: 4200, Fort Lauderdale, Florida, USA.

98. Bartoli M; Al-Shabrawey M; Platt D; Lemtalsi T; El-Remessy A; Caldwell RB. Activation of STAT3 in the Ischemic Retina and in Retinal Endothelial Cells Subjected to Hypoxia Is Dependent on NADPH Oxidase Activity. ARVO Meeting Abstracts, May, 2005; 46: 4205, Fort Lauderdale, Florida, USA.

99. Liou GI; El-Remessy A; Al-Shabrawey M; Tsai N; Roon P; Caldwell RB. Cannabidiol Preserves Retinal Neurons and Reduces Vascular Permeability in Experimental Diabetes. ARVO Meeting Abstracts, May, 2004; 45: 860, Fort Lauderdale, Florida, USA.

100. Behzadian A; El-Remessy A; Al-Shabrawey M; Ghaly N; Franklin T; Caldwell RB. Diabetes–induced Retinal Vascular Hyperpermeability Requires Urokinase Receptor (uPAR). ARVO Meeting Abstracts, May, 2004; 45:1100, Fort Lauderdale, Florida, USA.

101. El-Remessy A; Al-Shabrawey M; Behzadian A; Bartoli M; Platt D; Ghaly N; Tsai N; Caldwell RB. VEGF’s Angiogenic Function Involves Peroxynitrite–Mediated Activation of VEGFR2/Src/FAK. ARVO Meeting Abstracts, May, 2004; 45: 1886, Fort Lauderdale, Florida, USA.

102. Bartoli M; Al-Shabrawey M; Platt D; Lemtalsi T; El-Remessy A; Behzadian A; Caldwell RB. STAT3 activation in the ischemic retina and in retinal microvascular endothelial cells subjected to hypoxia. ARVO Meeting Abstracts, May, 2004; 45: 1892, Fort Lauderdale, Florida, USA.

103. Al-Shabrawey M; Bartoli M; Behzadian A; Platt D; El-Remessy A; Tsai N; Caldwell RB. Glial Cell Injury and VEGF Over–Expression Are Blocked by NADPH–Oxidase Inhibition in Ischemic Retinopathy. ARVO Meeting Abstracts, May, 2004; 45: 1892, Fort Lauderdale, Florida, USA.

104. Al-Shabrawey M, Bartoli M, Behzadian A, Platt D, El-Remessy A, Tsai N, Caldwell R. Hypoxia induces VEGF expression and retinal neovascularization by activating NADPH oxidase. Symposium on Retinal and Choroidal Angiogenesis, 2004. Nashville, Tennessee.

105. Platt D; Bartoli M; El-Remessy A; Al-Shabrawey M; Marrero M; Caldwell RB. Peroxynitrite Induces Transcriptional Activation of Vascular Endothelial Growth Factor in Bovine Retinal Endothelial Cells. ARVO Meeting Abstracts, May, 2003; 45: 2097, Fort Lauderdale, Florida, USA.

106. Al-Shabrawey M; Tsai N; Caldwell RB. Upregulation of Vascular NADPH-Oxidase Contributes to Retinal Angiogenesis. ARVO Meeting Abstracts, May, 2003; 45: 2914, Fort Lauderdale, Florida, USA.

107. Al-Shabrawey M, Hamed M and Caldwell R. Is nitric oxide synthase (NOS) involved in vascular development? American Society of Physiology meeting, Augusta-GA 1998.

PUBLICATIONS IN REFERRED JOURNALS 1-44

1. Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A. Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. Oncotarget. 2016;7:8532-8545

2. Faulkner J, Pye C, Al-Shabrawey M, Elmarakby AA. Inhibition of 12/15-lipoxygenase reduces renal inflammation and injury in streptozotocin-induced diabetic mice. Journal of diabetes & metabolism. 2015;6

3. Huang H, Al-Shabrawey M, Wang MH. Cyclooxygenase- and cytochrome p450-derived eicosanoids in stroke. Prostaglandins & other lipid mediators. 2016;122:45-53

4. Sobeih D, Hussein KA, Said N, Motamed K, Al-Shabrawey M. Deletion of sparc enhances retinal vaso-obliteration in mouse model of oxygen-induced retinopathy. HSOA journal of ophthalmology & clinical research. 2014;1

5. Al-Shabrawey M, Zhang W, McDonald D. Diabetic retinopathy: Mechanism, diagnosis, prevention, and treatment. BioMed research international. 2015;2015:854593

6. Abu El-Asrar AM, Mohammad G, Nawaz MI, Abdelsaid M, Siddiquei MM, Alam K, Van den Eynde K, De Hertogh G, Opdenakker G, Al-Shabrawey M, Van Damme J, Struyf S. The chemokine platelet factor-4 variant (pf-4var)/cxcl4l1 inhibits diabetes-induced blood-retinal barrier breakdown. Investigative ophthalmology & visual science. 2015;56:1956-1964

7. Ibrahim AS, Elshafey S, Sellak H, Hussein KA, El-Sherbiny M, Abdelsaid M, Rizk N, Beasley S, Tawfik AM, Smith SB, Al-Shabrawey M. A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via nadph oxidase. Journal of lipid research. 2015;56:599-611

8. Ibrahim AS, Tawfik AM, Hussein KA, Elshafey S, Markand S, Rizk N, Duh EJ, Smith SB, Al-Shabrawey M. Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids. Biochimica et biophysica acta. 2015;1851:290-298

9. Beasley S, El-Sherbiny M, Megyerdi S, El-Shafey S, Choksi K, Kaddour-Djebbar I, Sheibani N, Hsu S, Al-Shabrawey M. Caspase-14 expression impairs retinal pigment epithelium barrier function: Potential role in diabetic macular edema. BioMed research international. 2014;2014:417986

10. Tawfik A, Markand S, Al-Shabrawey M, Mayo JN, Reynolds J, Bearden SE, Ganapathy V, Smith SB. Alterations of retinal vasculature in cystathionine-beta-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia. The American journal of pathology. 2014;184:2573-2585

11. Hussein KA, Choksi K, Akeel S, Ahmad S, Megyerdi S, El-Sherbiny M, Nawaz M, Abu El-Asrar A, Al-Shabrawey M. Bone morphogenetic protein 2: A potential new player in the pathogenesis of diabetic retinopathy. Experimental eye research. 2014;125:79-88

12. Pye C, Elsherbiny NM, Ibrahim AS, Liou GI, Chadli A, Al-Shabrawey M, Elmarakby AA. Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms. Pharmacological research. 2014;85:45-54

13. Eid AA, Hussein KA, Niu LN, Li GH, Watanabe I, Al-Shabrawey M, Pashley DH, Tay FR. Effects of tricalcium silicate cements on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells in vitro. Acta biomaterialia. 2014;10:3327-3334

14. Abu El-Asrar AM, Midena E, Al-Shabrawey M, Mohammad G. New developments in the pathophysiology and management of diabetic retinopathy. Journal of diabetes research. 2013;2013:424258

15. Al-Shabrawey M, Elsherbiny M, Nussbaum J, Othman A, Megyerdi S, Tawfik A. Targeting neovascularization in ischemic retinopathy: Recent advances. Expert review of ophthalmology. 2013;8:267-286

16. Othman A, Ahmad S, Megyerdi S, Mussell R, Choksi K, Maddipati KR, Elmarakby A, Rizk N, Al-Shabrawey M. 12/15-lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: Contribution of nadph oxidase. PloS one. 2013;8:e57254

17. Tawfik A, Al-Shabrawey M, Roon P, Sonne S, Covar JA, Matragoon S, Ganapathy PS, Atherton SS, El-Remessy A, Ganapathy V, Smith SB. Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia. Investigative ophthalmology & visual science. 2013;54:939-949

18. Mohammad G, Siddiquei MM, Othman A, Al-Shabrawey M, Abu El-Asrar AM. High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina. Experimental eye research. 2013;107:101-109

19. Al-Shabrawey M, Ahmad S, Megyerdi S, Othman A, Baban B, Palenski TL, Shin ES, Gurel Z, Hsu S, Sheibani N. Caspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy. Molecular vision. 2012;18:1895-1906

20. Kaddour-Djebbar I, Choudhary V, Lakshmikanthan V, Shirley R, El Gaish M, Al-Shabrawey M, Al-Husein B, Zhong R, Davis M, Dong Z, Bollag WB, Kumar MV. Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death. The Journal of pharmacology and experimental therapeutics. 2012;341:646-655

21. Akeel S, El-Awady A, Hussein K, El-Refaey M, Elsalanty M, Sharawy M, Al-Shabrawey M. Recombinant bone morphogenetic protein-2 induces up-regulation of vascular endothelial growth factor and interleukin 6 in human pre-osteoblasts: Role of reactive oxygen species. Archives of oral biology. 2012;57:445-452

22. Hussein KA, Zakhary IE, Elawady AR, Emam HA, Sharawy M, Baban B, Akeel S, Al-Shabrawey M, Elsalanty ME. Difference in soft tissue response between immediate and delayed delivery suggests a new mechanism for recombinant human bone morphogenetic protein 2 action in large segmental bone defects. Tissue engineering. Part A. 2012;18:665-675

23. El-Asrar AM, Nawaz MI, Kangave D, Geboes K, Ola MS, Ahmad S, Al-Shabrawey M. High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy. Molecular vision. 2011;17:1829-1838

24. Elmarakby AA, Faulkner J, Al-Shabrawey M, Wang MH, Maddipati KR, Imig JD. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. American journal of physiology. Regulatory, integrative and comparative physiology. 2011;301:R1307-1317

25. Zhang W, Liu H, Al-Shabrawey M, Caldwell RW, Caldwell RB. Inflammation and diabetic retinal microvascular complications. Journal of cardiovascular disease research. 2011;2:96-103

26. Al-Shabrawey M, Mussell R, Kahook K, Tawfik A, Eladl M, Sarthy V, Nussbaum J, El-Marakby A, Park SY, Gurel Z, Sheibani N, Maddipati KR. Increased expression and activity of 12-

lipoxygenase in oxygen-induced ischemic retinopathy and proliferative diabetic retinopathy: Implications in retinal neovascularization. Diabetes. 2011;60:614-624

27. Al-Shabrawey M, Smith S. Prediction of diabetic retinopathy: Role of oxidative stress and relevance of apoptotic biomarkers. The EPMA journal. 2010;1:56-72

28. Wu M, Kodani I, Dickinson D, Huff F, Ogbureke KU, Qin H, Arun S, Dulebohn R, Al-Shabrawey M, Tawfik A, Prater S, Lewis J, Wataha J, Messer R, Hsu S. Exogenous expression of caspase-14 induces tumor suppression in human salivary cancer cells by inhibiting tumor vascularization. Anticancer research. 2009;29:3811-3818

29. Rojas M, Zhang W, Lee DL, Romero MJ, Nguyen DT, Al-Shabrawey M, Tsai NT, Liou GI, Brands MW, Caldwell RW, Caldwell RB. Role of il-6 in angiotensin ii-induced retinal vascular inflammation. Investigative ophthalmology & visual science. 2010;51:1709-1718

30. Abdelsaid MA, Pillai BA, Matragoon S, Prakash R, Al-Shabrawey M, El-Remessy AB. Early intervention of tyrosine nitration prevents vaso-obliteration and neovascularization in ischemic retinopathy. The Journal of pharmacology and experimental therapeutics. 2010;332:125-134

31. Bartoli M, Al-Shabrawey M, Labazi M, Behzadian MA, Istanboli M, El-Remessy AB, Caldwell RW, Marcus DM, Caldwell RB. Hmg-coa reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy. Investigative ophthalmology & visual science. 2009;50:4934-4940

32. Tawfik A, Sanders T, Kahook K, Akeel S, Elmarakby A, Al-Shabrawey M. Suppression of retinal peroxisome proliferator-activated receptor gamma in experimental diabetes and oxygen-induced retinopathy: Role of nadph oxidase. Investigative ophthalmology & visual science. 2009;50:878-884

33. Al-Shabrawey M, Rojas M, Sanders T, Behzadian A, El-Remessy A, Bartoli M, Parpia AK, Liou G, Caldwell RB. Role of nadph oxidase in retinal vascular inflammation. Investigative ophthalmology & visual science. 2008;49:3239-3244

34. Al-Shabrawey M, Bartoli M, El-Remessy AB, Ma G, Matragoon S, Lemtalsi T, Caldwell RW, Caldwell RB. Role of nadph oxidase and stat3 in statin-mediated protection against diabetic retinopathy. Investigative ophthalmology & visual science. 2008;49:3231-3238

35. El-Remessy AB, Al-Shabrawey M, Platt DH, Bartoli M, Behzadian MA, Ghaly N, Tsai N, Motamed K, Caldwell RB. Peroxynitrite mediates vegf's angiogenic signal and function via a nitration-independent mechanism in endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007;21:2528-2539

36. Ma G, Al-Shabrawey M, Johnson JA, Datar R, Tawfik HE, Guo D, Caldwell RB, Caldwell RW. Protection against myocardial ischemia/reperfusion injury by short-term diabetes: Enhancement of vegf formation, capillary density, and activation of cell survival signaling. Naunyn-Schmiedeberg's archives of pharmacology. 2006;373:415-427

37. El-Remessy AB, Al-Shabrawey M, Khalifa Y, Tsai NT, Caldwell RB, Liou GI. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. The American journal of pathology. 2006;168:235-244

38. Platt DH, Bartoli M, El-Remessy AB, Al-Shabrawey M, Lemtalsi T, Fulton D, Caldwell RB. Peroxynitrite increases vegf expression in vascular endothelial cells via stat3. Free radical biology & medicine. 2005;39:1353-1361

39. Al-Shabrawey M, Bartoli M, El-Remessy AB, Platt DH, Matragoon S, Behzadian MA, Caldwell RW, Caldwell RB. Inhibition of nad(p)h oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy. The American journal of pathology. 2005;167:599-607

40. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH, Liou GI, Caldwell RW. Vascular endothelial growth factor and diabetic retinopathy: Role of oxidative stress. Current drug targets. 2005;6:511-524

41. Caldwell RB, Bartoli M, Behzadian MA, El-Remessy AE, Al-Shabrawey M, Platt DH, Caldwell RW. Vascular endothelial growth factor and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives. Diabetes/metabolism research and reviews. 2003;19:442-455

42. Al-Shabrawey M, El-Remessy A, Gu X, Brooks SS, Hamed MS, Huang P, Caldwell RB. Normal vascular development in mice deficient in endothelial no synthase: Possible role of neuronal no synthase. Molecular vision. 2003;9:549-558

43. Gu X, El-Remessy AB, Brooks SE, Al-Shabrawey M, Tsai NT, Caldwell RB. Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite. American journal of physiology. Cell physiology. 2003;285:C546-554

44. Behzadian MA, Wang XL, Al-Shabrawey M, Caldwell RB. Effects of hypoxia on glial cell expression of angiogenesis-regulating factors vegf and tgf-beta. Glia. 1998;24:216-225

BOOK CHAPTER

45. Behzadian A, Bartoli M, El-Remessy A, Al-Shabrawey M, Platt D, Liou GI, Caldwell RW, and Caldwell RB. Cellular and Molecular Mechanism of Retinal Angiogenesis. What have we learned from in vitro models?. John S. Penn (ed) In Retinal and Choroidal Angiogenesis, 1-39. Springer Science Business Media B.V. 2008.

46. Al-Shabrawey M and Smith SB. Oxidative Stress and Apoptotic Biomarkers in Diabetic Retinopathy. Sponsored by European Association for Predictive, Preventive and Personalized Medicine. Springer, 2013, Volume 3, page: 175-209. DOI: 10.1007/978-94-007-5971-8. ISBN:978-94-007-5970-1

PUBLICATIONS IN NON-REFERRED JOURNALS

1. Al-Shabrawey M. and Peterman D. Faculty and Student Perspectives about published rview article “Faceboo: is it medical education’s next hidden curriculum? Journal Scout, Georgia Regent University, May 2015. Link: https://grujournalwatch.wordpress.com/category/issue-may-2015/

2. Al-Shabrawey M and Eltahry HM. Glial-induced retinal angiogenesis: the contribution of Transforming growth factor-beta and metalloprotinases. Egyptian J. Anatomy. 2000; 23(1), 91-118

3. Al-Shabrawey M, Hamed M and Caldwell RB. Decreased vascular density and increased nitric oxide synthase activity in the retina of mouse with photoreceptor degeneration (rd+ mouse). Egyptian J. Anatomy (2001).

TEACHING, ADVISING AND MENTORING TEACHING

I have been participating in teaching and directing Gross anatomy and Neuroscience since 2002. Anatomy course includes didactic and anatomy lab teaching in which the whole body is dissected by students with direct supervision by the instructors. 2012- Present Course Director of Head and Neck Anatomy (DANA5002) 2012-Present Course Director of Neuroscience (DANA5003) 2008-2014 Course Director of Systemic Anatomy (DANA5004) 2010-2011 Director of Seminar Series, Oral Biology, College of Dental Medicine, 2012-2013 Course Director of Developmental Biology (DBIO5002) Summary of the average teaching responsibilities 2006-Present

A. Pre-doctoral program (Dental Students), Dental College of Georgia-Augusta University

Course # Title Total/MA hrs

1. DANA 5002 Applied Head and Neck anatomy 94/54 2. DANA 5004 Systemic Anatomy 64/43 3. OBMP 5601 Bioclinical seminar 14/14 4. OBMP 5602 Bioclinical seminar 17/17 5. DANA 5003 Neuroscience 42/20 6. OBMP 5003 National Board Review of Anatomy 10/6

B. Continuing Medical Education

1. Clinical Anatomy of Head and Neck, American Association of Implant Dentistry (AAID): Maxi course in implant dentistry.

2. Clinical Anatomy of Head and Neck, Medical College of Georgia, Augusta-GA

C. Ocular Anatomy as a part of the Vision Science Course School of Graduate Studies (Ph.D students) (2011-Present)

D. International Teaching Experience

1999- 2002 Mansoura Faculty of Medicine-Egypt, Human Anatomy, Neuroscience and Medical Embryology

1998 Medical College of Georgia, Georgia-USA, lectures and laboratory course in Neuroanatomy

1991-1996 Mansoura Faculty of Medicine-Egypt, Human Anatomy, Neuroscience and Medical Embryology

STUDENTS, FELLOWS AND TRAINEES

A. Graduate Students

Student Degree Yrs Research topic Current position

Sara Akeel

(Major Advisor)

Ph.D 2007-2012

The interaction between the angiogenic and osteogenic factors during bone healing

Head of Oral Diagnostic Science Department, King AbdulAziz University, KSA

Khalid Hussein

(Advisory committee member)

Ph.D 2010-2013

Mechanism of rhBMP2 action on large segmental bone defect

Scientist in Oral and Dental Research, National Research Center, Egypt

Folami Lamoke

(Advisory committee member)

Ph.D 2011-213

Thioredoxin system in diabetic retinopathy

Postdoctoral Fellow, Ophthalmology Dep., GRU

Karishma Choksi

(Major Advisor)

M.Sc 2011-2013

Impact of Hyperglycemia on Osteoblast function

Resident of Geriatric Dentistry, UCLA

Sean Connolly

(Advisory committee member)

M.Sc 2011-2013

Mapping of cellular and molecular early events in periodontal wound healing using canine model

Esam Abu Nahlah

(Advisory committee member)

M.Sc 2011-2013

Role of Diabetes and12/15-Lipoxygenase Deficiency in Mouse Bone

Board Certified Prosthodontist, Private Practice

Esraa Shosha

(Advisory committee member)

Ph.D 2013-Present

Role of Arginase in ischemia-reperfusion injury of retina

PhD Candidate

Khaled El masry

(Major Advisor)

Ph.D 2015-Present

Role of exosomes in bioactive lipids-mediated retinal microvascular dysfunction in diabetes

PhD Candidate

B. Postdoctoral Fellows

Postdoctoral Fellow Years Research topic Current position

Amany Tawfik, Msc, MD

2008-2009 NADP oxidase in diabetic retinopathy

Assistant Professor in Oral Biology and Anatomy, AU

Mohamed ElAdl, MD, Ph.D

2008-2009 Production of HETE in Proliferative Diabetic Retinopathies

Lecturer of Anatomy, College of Medicine, Mansoura University, Egypt

Ahmed Saif, PhD 2010-2011 Role of Caspase 14 and diabetic retinopathy

Associate Professor, King AbdulAziz University, KSA

Amira Othman, MD, PhD

2012-2013 Lipoxygenase pathway in diabetic retinopathy

Lecturer of Anatomy, College of Medicine, Helwan University, Egypt

Khalid Hussein, BDS, PhD 2013-2015 BMP2/smad pathway in retinal endothelial cell dysfunction in diabetic retinopathy

Scientist in Oral and Dental Research, National Research Center, Egypt

Ahmed Ibrahim, Pharm D, PhD

2013-Present

Bioactive lipids and retinal inflammatory response in diabetic retinopathy

Lecturer of Biochemistry, College of Pharmacy, Mansoura University, Egypt

Mohamed Elsherbiny, MD, PhD

2013-2014 Role of 12/15-lipoxygenase in leukocyte/endothelial cell interaction in ischemic retinopathy

Lecturer of Anatomy, College of Medicine, Mansoura University, Egypt

Doaa Sobeih, MD 2013-2014 Role of SPARC in retinopathy of prematurity

Ophthalmologist, Marsa Matrooh hospital-Egypt

Fang Wang, MD, PhD 2014-2015 BMP2/smad pathway and retinal pigment epithelial cell barrier function

Lecturer of Traditional Chinese Medicine, School of Medicine JiangHan University Wuhan, China

Heba Saleh, MD 2015 Role of NOX4 in blood retinal barrier function

Postdoctoral Fellow, Oral Biology and Anatomy Dep., AU

Mohamed Elshafey, MD, PhD

2016-Present

Role of platelets in the development of diabetic retinopathy

Lecturer of Anatomy, College of Medicine, Mansoura University, Egypt

Nehal Elsherbiny, Pharm D, PhD

2015-2016 Interplay between VEGF signaling and 12/15- Lipoxygenase system in Endothelial cells

Lecturer of Biochemistry, College of Pharmacy, Mansoura University, Egypt

Mohamed Katary, Pharm D, PhD

06-2016-

Role of Lipoxygenase in LPS-mediate renal injury

Lecturer of Pharmacology, College of Pharmacy, Damnhur University, Egypt

C. TRAINEES

Student Title Yrs Research topic Current position

Farid Khan

Summer Medical Student of MCG-AU

2014-2015

Lipoxygenase pathway in traumatic optic neuropathy

Medical Student (MC)

Michael Hall Summer Medical Student of DCG-AU

2015 BMP2/smad pathway in diabetic retinopathy (DR)

Dental Student

(DCG)

Deric Thomson Summer Medical Student of DCG-AU

2016 Impact of hyperglycemia on osteoblast function

Dental Student (DCG)

Humma Hassan AU-Summerville Campus

2015 Characterization of Del-1 in ischemic retinopathy model

Pre-medical Student

(AU)

Sammy Elmor Summer Pre-Med Student of UGA

2016 Characterization of Del-1 in ischemic retinopathy model

Pre-medical Student (UGA)

Ibrahim Khalil Summer Pre-Med Student of UGA

2016 Role of platelets in the development of DR

Pre-medical Student (UGA)

Ibtesam Atemna

Summer Pre-Med Student of UGA

2016 Role of platelets in the development of DR

Pre-medical Student (UGA)

Sally El-shafaey Msc, BDS Research Assistant

2013-2014

Bioactive lipids and retinal inflammatory response in diabetic retinopathy

Research Associate-Physiology (MCG)

Yara Samra Msc in pharmaceutical science

2015- Role of ADA2 in Diabetic Retinopathy

PhD student in pharmaceutical science (Mansoura University)

Rene Mussel

MD 2008 12/15 lipoxygenase and diabetic retinopathy

Resident of Emergency Medicine, West Virginia University

Khalid Kahook MD 2008-2009

12/15 lipoxygenase and pathological retinal neovascularization

Resident of Ophthalmology, Detroit, MI

EXAMINING COMMITTEE:

Candidate Degree And Exam Date

Usman Ullah Final Msc Thesis Exam, University of Lahore, Pakistan 2011

Sara Akeel Final PhD Thesis Exam, GSHU 2012

Farhana Jafri Final Msc Thesis Exam, University of Lahore, Pakistan 2012

KAMRAN AMEER Final Msc Thesis Exam, University of Lahore, Pakistan 2013

Khalid Hussein Final PhD Thesis Exam, GSHU 2013

Folami Lamoke Final PhD Thesis Exam, GRU 2013

Rukhsana Jabeen Final Msc Thesis Exam, University of Lahore, Pakistan 2013

Amna Mubeen Final Msc Thesis Exam, University of Lahore, Pakistan 2013

Alia Amin Final Msc Thesis Exam, University of Lahore, Pakistan 2015

Sania Asif Final Msc Thesis Exam, University of Lahore, Pakistan 2016

CLINICAL EXPERIENCE

1999-2002 General Practitioner (Public hospitals and private clinic, Mansoura-Egypt) 1992-1996 General Practitioner (Public hospitals and private clinic, Mansoura-Egypt) 1990-1991 Resident in Military hospitals-Egypt (internal medicine/Pediatric) 1989-1990 Internship (Mansoura University Hospital-Mansoura-Egypt)