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Antibody Associated Disease Main Symptoms

Anti-Cardiolipin

IgG > 10

IgM > 7

Anti-Phospholipid Syndrome

Primary or Secondary to SLE

Thromboses

Recurrent Spontaneous Abortions

Skin Rash (Livedo Reticularis)

Thrombocytopenia

Anti-Centromere CREST

Limited Cutaneous Scleroderma

12% of Pts with Primary Biliary Cirrhosis

Calcinosis

Raynauds

Esophageal Dysfunction

SclerodactylyTelangectasias

Anti-dsDNA SLE Malar Rash

Photosensitivity

Aphthous Ulcers

Pleuritis

Pericarditis

Arthritis

Raynauds

Nephritis

Anti-U1-Ribonucleoprotein (RNP) Mixed Connective Tissue Disease

SLEAnti-Sm SLE (Mainly Afro-Caribbean)

Associated with RNP

Anti-Ro (SS-A) Primary Sjogrens

Subacute Cutaneous Lupus Erythematosus

Neonatal Lupus

Congenital Complete Heart Block in Babies

born to SLE Mothers

SLE with Interstitial Pneumonitis

Anti-La (SS-B) Primary Sjogrens

SLE

Anti-Jo-1 Aggressive Polymyositis

Dermatomyositis

Interstitial Lung Disease

Arthralgia

Anti-Scl-70 Progressive Systemic Sclerosis

Limited Scleroderma

Anti-Histone

Positive > 5u/mL

Drug Induced SLE

SLE

Arthritis

Pleuritis

Pericarditis

Anti-Nuclear (ANA)

Titres > 40

SLE (Titres > 80)

Juvenile Chronic Arthritis

Sjogrens

Fibrosing Alveolitis

Chronic Active Hepatitis

EBV and CMVAnti-Nuclear (ANA) Speckled

Titres > 40

SLE

Mixed Connective Tissue Disease

Sjogrens

Scleroderma

Anti-Nucleolar

Titres > 40

Scleroderma

SLE

Polymyositis

Anti-Ribosome

Titres > 40

SLE

RA

Neuropsychiatric Symptoms

Nephritis

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Anti-PM-1 Polymyositis/Scleroderma Overlap

Anti-Mi-2 Dermatomyositis

Anti-SRP Polymyositis

Dermatomyositis

Rheumatoid Factor (RF)

Titres > 25 IU/mL

Rheumatoid Arthritis

Inflammatory Arthritis

Vasculitis

Nodules

Anti-CCP

Titres > 10 U/mL

Predict RA development in Undifferentiated

Arthritis

Anti-Tissue TransglutaminaseIgA >15 EU/mL

Celiac Disease

Anti-Endomysial (EMA) Celiac Disease

Dermatitis Herpetiformis

Anti-Gliadin Celiac Disease

Dermatitis Herpetiformis

Gluten Sensitivity

Anti-Gastric Parietal Cell (GPC)

Titre > 40

Pernicious Anemia

Early Stages of Atrophic Gastritis (Type A)

Anti-Intrinsic Factor (IFA)

Titre > 20 RU/mL

Pernicious Anemia

Anti-Liver-Kidney-1 (LKM-1)Titre > 40

Type 2a and 2b Autoimmune HepatitisAssociated with Hep C infection

Anti-Liver-Kidney-2 (LKM-2)

Titre > 40

Drug Induced Hepatitis

Anti-Liver-Kidney-3 (LKM-3)

Titre > 40

Hepatitis D

Anti-Mitochondrial (M1)

Titre > 40

Positive Syphilis Serology

Anti-Mitochondrial (M2)

Titre > 40

Primary Biliary Cirrhosis

Chronic Active Hepatitis

Autoimmune Thyroiditis

SjogrensAnti-Mitochondrial (M5)

Titre > 40

SLE

Antiphospholipid Syndrome

Anti-Smooth Muscle

Titre > 40

Autoimmune Hepatitis

Anti-Adrenal Addisons

Anti-Islet Cell Type I Diabetes Mellitus

Anti-Steroid Cell Type I Autoimmune Polyendocrinopathy

Premature Gonadal and Ovarian Failure

Anti-Thyroperoxidase (TPO)

Titre > 135 IU/mL

Graves

Primary Myxedema

Hashimotos

Pernicious Anemia

Addisons

Anti-Microsomal Hashimotos

Anti-Thyroglobulin Hashimotos

Anti-TSH Receptor Graves

Anti-AChR

Titre > 5x10 -10 M

Myasthenia Gravis

Anti-Ganglioside GM-1

N = 0 - 200

Guillain Barre Syndrome (GBS)

Chronic Demyelinating Polyneuropathy

Multifocal Motor Neuropathy

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Anti-Ganglioside GQ1b

N = 025

Miller Fisher variant of GBS

Anti-Glutamate Decarboxylase

N = 01 U/mL

Type I Diabetes Mellitus

Stiff Man Syndrome

Anti-Muscle Specific Kinase Myasthenia Gravis

Anti-Paraneoplastic

Yo (PCCA)

Hu (ANNA-1)

Ri (ANNA-2)

Paraneoplastic Disorders

Anti-Skeletal Muscle

Titre > 10

Myasthenia Gravis

Thymomatous Myasthenia Gravis

Acute Viral Hepatitis

Polymyositis

Anti-Voltage Gated Ca Channel

Titre > 45 pM

Lambert-Eaton Myasthenic Syndrome

Anti-Voltage Gated K Channel

Titre > 100 pM

Acquired Neuromyotonia

C3 Nephritic Factor Mebranoproliferative GN (Type II)

Partial Lypodystrophy

Anti-GBMTitre > 10 EU/mL

Goodpastures

Anti-Neutrophil Cytoplasmic

(ANCA)

Titre > 20

Drug Induced Vasculitis

C-ANCA (Proteinase 3)

Titre > 2 U/mL

Generalized Wegners

Microscopic Polyangitis

P-ANCA (Myloperoxidase)

Titre > 6 U/mL

Active Microscopic Polyangitis

P-ANCA (Non-MPO) Inflammatory Bowel Disease

Sclerosing Cholangitis

RA

SLE

Chronic Active Hepatitis

Anti-C1q

Titre > 15 U/mL

Renal Disease Activity in SLE

Hypocomplementaemic Urticarial Vasculitis

Anti-Cardiac Muscle Dresslers Syndrome

Post Cardiotomy Syndrome

Anti-IgA Selective IgA Deficiency Blood Product Transfusion RXNs

Skin Reactive

(Anti-Intercellular/Desmosome)

(Anti-Desmoglein)

Pemphigus

Skin Reactive

(Anti-Basement Membrane)

Bullous Pemphigoid