Alzheimer’s Disease Research AntibodiesOver 65 Antibodies For Studying Alzheimer’s Disease

Detection of mouse IP3R1 in a FFPE section of cerebellum by IF. Antibody: Rabbit anti-IP3R1 antibody, Cat#

A302-158A.

Alzheimer’s Disease Research AntibodiesBethyl Laboratories, Inc. is dedicated to improving lives by supporting scientific discovery through its qualified antibody products and custom antibody services. Since its founding in 1972, Bethyl has manufactured all of its antibodies on-site to exacting standards with validation to a range of applications.

Below is a sampling of select antibodies targeting proteins involved in Alzheimer’s diease. For a complete product listing, please visit: bethyl.com/antibody/Neurobiology+Alzheimers+Disease.

Target Reactivities Applications # of Abs AbVantage™ Pack

ATF6 Hu WB, IP, IF, IHC 2 Yes

ATP2A2/SERCA2 Hu, Rt, Pg, Rb WB, IP 1

ATP5A1 NEW Hu, Ms WB, IP 2 Yes

BAD Hu, Ms IP, IF, IHC 2

BID* Hu, Ms WB, IF, IHC 6 Yes

CASP3/Caspase 3 Hu WB, IP, IF, IHC 1

COX4I1/COX4 Hu WB, IP, IF, IHC 2

CREB1/CREB Hu, Ms WB, IP, IF, IHC, PLA 2

CTNNB1/beta-catenin Hu, Ms WB, IP, IF, IHC, PLA 4 Yes

EFHD2/Swiprosin-1 NEW Hu IP 1

FAS Hu WB, IP 1

GAPDH** Hu, Ms, Rt WB, IF, IHC, PLA 9 Yes

GSK3B/GSK3-beta Hu, Ms WB, IP, PLA 2 Yes

IDE Hu WB 1

ITPR1/IP3R1 Hu, Ms WB, IP, IF, IHC 2 Yes

ITPR3/IP3R3 Hu WB, IP, IF, IHC 3 Yes

MAPK1/ERK2 Hu, Ms WB, IF, IHC, PLA 2

MAPK14/p38 MAPK Hu, Ms WB, IP 2 Yes

MAPK3/ERK1* Hu WB, IP, IF, IHC, PLA 4 Yes

NCSTN/Nicastrin Hu WB, IP 1

NOTCH1 Hu WB, IP, IF, IHC, PLA 3 Yes

PPP2R5D Hu, Ms WB, IP 3 Yes

PPP3CA Hu, Ms WB, IP, IF, IHC 3 Yes

PPP5C Hu, Ms WB, IP, IF, IHC, PLA 2

PSEN2/Presenilin-2 Hu WB, IP, IF, IHC 1

PTGS2/COX-2 Hu WB, IP, IF, IHC 1

TP53/p53 Hu WB, IP, IF, IHC, F, PLA 4 Yes

Detection of human Notch1 by WB of IPs

from HeLa cell lysate. Antibodies: Rabbit

anti-Notch1 antibody, Cat# A301-895A

used for IP and WB. Notch1 was also IP’d

by Cat# A301-894A, which recognizes a

different epitope.

Detection of human BID in a FFPE of a

colon adenocarcinoma by IHC. Antibody:

Rabbit anti-BID antibody, Cat# IHC-00121.

All antibodies are antigen affinity purified.*Phospho-specific available

**mAb, pAb available

Detection of mouse IP3R1 (red) and

nucleolin (green) in cerebellum by IF.

Antibodies: Rabbit anti-IP3R1 antibody,

Cat # A302-158A, and rabbit anti-

Nucleolin (NCL), Cat# A300-711A. Goat

anti-rabbit IgG (H+L) cross-adsorbed,

DyLight® 594 and goat anti-rabbit IgG

(H+L) cross-adsorbed, DyLight® 488, Cat#

A120-201D2.

Select Journal Citations

Target Title Journal

GAPDH LPS-induced microglial secretion of TNFa increases activity-dependent neuronal apoptosis in the neonatalcerebral cortex.

Cereb Cortex. 2013 Jul;23(7):1742-55.

CASP3 / Caspase 3

REDD1/DDIT4-independent mTORC1 Inhibition and Apoptosis by Glucocorticoids in Thymocytes.

Mol Cancer Res. 2014 Mar 10.

ITPR1 / IP3R1 Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

Nature. 2012 Apr 8;485(7396):128-32.

MAPK1 /

ERK2

Decay of y-H2AX foci correlates with potentially lethal damage repair

and P53 status in human colorectal carcinoma cells.

Cell Mol Biol Lett. 2013

Dec 23.