an interesting congress in a wonderful and warming …
TRANSCRIPT
Indice_Bn-Jou-8-pag-okAN INTERESTING CONGRESS IN A WONDERFUL AND
WARMING CITY: BEIJING Xing-Hua Gao1, Jianzhong Zhang2 , Hong-Duo
Chen1 and Piefrancesco Morganti3 1 Department of Dermatology, No.1
Hospital of China Medical University, Shenyang, China 2 Department
of Dermatology, People’s Hospital of Beijing University, China 3
Skin Pharmacology, Department of Dermatology, 2nd University of
Naples, Italy
J. Appl. Cosmetol. 32, 131-138 (July/December 2014) Special Reports
131
In the wonderful setting of the magic city of Beijing, from September 26 to 28, 2014, was successfully held the 11th International Congress of Cosmetic Dermatology, organized by Chinese Society of Dermatology, Peking University People's Hospital No. 1, and China Medical University, under the auspices of International Society of Cosmetic Dermatology. There were 309 submissions included in the Congress proceedings, among them 135 papers were presented during the two-day events. After the introductory remarks reported from Wei Liu, Head of Dermatological Department, Air Force Hospital of Beijing, Ya-Fei Liu Deputy President of Chinese Medical Association, Hong-Duo Chen, President of International Society of Cosmetic Dermatology, Jian-Zhong Zhang, President of Chinese Society of Dermatology and Pierfrancesco Morganti, as Secretary General of the International Society of Cosmetic Dermatology the Meeting started by 5 Plenary Lectures which have opened a door for the Innovation in Horizon, where the green eco- nomy will be at the center of the future progress. Dozens of world renowned dermatologists and scientists presented on a variety of topics cove- ring laser treatment, usage of retinoic acid, skin rejuvenation, fillers, dermatologic surgery, photo-protection, antioxidant in cosmetic condi- tions, skin imaging and skin bioengineering, tra- ditional Chinese medicine in cosmetic dermato- logy, complications and pitfalls in cosmetic der- matology, et al. In addition, topics on cosmetic
regulation, impact of environmental pollutions on skin, view of beauty from East and West were also hotly discussed. Prof. Henry Lim from Henry Ford Medical System explained in details what’s new in photoprotection. Prof. Pierfrancesco Morganti, secretary general of International Society of Cosmetic Dermatology, outlined the bright future of deve- loping environmental friendly cosmetic pro- ducts. Prof. Evangeline Handog, president of International Society of Dermatology, stressed specifically the management of pigmentary alte- rations in acne. Prof. Sewon Kang from John Hopkins University presented the influence of epigenetics on skin aging. Prof. Jianzhong Zhang, Congress president and president of Chinese Society of Dermatology, discussed basic and specific classification of androgenetic alopecia and Chinese guideline for management of AGA. Prof. George Cotsarelis from University of Pennsylvinia introduced cellular and molecular understanding of androgenetic alopecia. Prof. Xing-Hua Gao, Congress presi- dent from China Medical University, displayed the treatment advances in recalcitrant vitiligo and vitiligo with prominent cosmetic conse- quences. Prof. Mark Pittelkow from Mayo Clinic, educated on the recent advances in scar- ring. The new concepts and new technologies in cosmetic dermatology were fully communicated during this congress. Stress, oxidants and pollu- tion at the base of many skin disorders, together
3_Special Reports_Morganti_14 20/02/15 15:42 Pagina 131
with the more modern therapeutic means used today to solve many pathologies affecting skin and hair, were reported and discussed by scien- tists coming from the main China, Japan, Philippines, South Korea, USA and Europe. Skin, in fact, serving as a barrier against all the external assaults is the potential target of the environmental oxidative stress, one of the major determinants in skin aging. Thus, when the natu- ral antioxidant defence mechanisms fail, or an increased flux of reactive oxidants from endo- and exogenous sources exceed the skin antioxi- dant capacity, oxidative injury will result. Oxidative stress, therefore, is referred to as a condition of imbalance of pro-oxidant/antioxi- dant equilibrium, in favour of the former. According to Achimichi Morita from Nagoya City a University, Japan, some epidemiologic studies have shown that water-soluble tobacco- smoking extract induced skin aging, the produc- tion of metalloproteinases (which degrade colla- gen), resulted increased as well as the hydrocar- bon receptors, which mediate the toxicity of several environmental contaminants were trig- gered. On the other hand, Umberto Cornelli, from Loyola University School of Medicine, Chicago, USA, has underlined the connection between the oxidative stress and the total chole- sterol, considered at the basis of hydroperoxide plasma levels. Moreover, according to Tie-Chi Lei, from Dermatological Department of Wuhan University, China, the oxidative stress, provoked from hydroquinone used as depigmenting agent, seems to be the main cause of the melanosome degradation, acting as a pro-oxidant agent. These studies open the door for the treatment of post inflammatory hyperpigmentation (PIH), a common sequelae of inflammatory Dermatoses, as shown in acne-affected patients, where a combination therapy is necessary, according to Evangeline B.Handog from Asian Hospital and Medical Center, Philippines, and Henry W Lim, from Dermatological Department of Henry Ford
Hospital, Detroit, USA. In the treatment of PIH, Lin has combined topical corticosteroids as mono therapy to monobenzyl ether of hydroqui- none, underlining how the chronic use of these ingredients can be cause of permanent depig- mentation, provoking vitiligo-like side effect. Vitiligo treatment has been the topic of Xing- Hua Gao, Department of Dermatology, No 1 Hospital of China Medical University, and Shenyang. He showed Interesting results obtai- ned on severe vitiligo-lesions on face, treated by calcineurin inhibitors and/or phototherapy. Unfortunately, vitiligo on hands and feet resul- ted very resistant to conventional treatments, while ablative laser-aided steroid delivery com- bined with UV-therapy irradiation seem to be the best promising therapy. Photodynamic and laser therapy, hypo and hyperpigmentary disorders and the use of stem cells, growth factors and new technologies to minimize the problem of keloids and improve the microenvironment or skin aging, were among all the more discussed topics. Nanobiotechnology, in fact, promises to revolu- tionise the use of biomolecular processes, at cell level by the development of new nanocomposi- tes and devices for biological and biomedical applications. Scientists, in fact, have harnessed the cell' ability to interact with other cells for developing new material with a living compo- nent. Restoration of aged skin and burned, wounded tissues are the possible applications by the use of advanced natural fibres entrapping active ingredients obtained from stem cells also, according to Yu Yanqiu, Department of Pathophysiology and Hangdeng Tu and Yuannhong Li, Department of Dermatology China Medical University of Shenyang. About the future of the cell therapy by stem cells, it has been underlined how some in progress studies aim to restore faith in the use of gene therapy of Primary immune deficiencies (PIDs) This study utilises genetically modified haemapoietic stem
Special Reports
3_Special Reports_Morganti_14 20/02/15 15:42 Pagina 132
cells' as a cell-based therapy for building a healthy immune system in patients with PIDs .In addition Marco Palombo, Burn Unit and Plastic Department, S. Eugenio Hospital, Rome, Italy, reported his personal experience on the utiliza- tion of new advanced medications made by a specialized nanocomposite tissue based on the use of Chitin Nanofibrils and plant polymers, entrapping active cicatrizing and antibacterial agents. The goal of this treatment on burned skin has been to obtain a complete reconstruction of the skin in a week maintaining the bandage in loco for all the period, without any kind of bac- terial invasion. Naturally, during the discussion it has been underlined how the use of new cosmetic pro- ducts of recognized high quality (based on the use on block-copolymer nanoparticles) and/or topical devices of new generation (obtained by the use of natural polymers and casting and elec- trospinning technologies) may represent innova- tive solutions for advanced medications and beauty masks for the treatment of photo-aged or precociously aged skin. In any way, all the pro- ducts have to be well regulated by the interna- tional laws to enhance the consumer protection, as well as to be also protected by patents to safe- guard the intellectual properties both of research and industry. Last but not least, there is a growing necessity to recognize that the transition to a green-bio-eco- nomy, based on the use of waste materials and bio-nano-technologies, consuming low quantity of water and energy, could generate a more sustainable growth. This new way of producing goods will address the decline/loss of ecosystem services, slowing down the increasing natural disasters, preserving the natural resources, and maintaining the biodiversity of the planet. For these reasons biotechnology will be an impor- tant pillar of Europe's economy by 2030 as well as of USA and China economy to meet the futu- re global challenge of a sustainable industry.
On one hand, medicine and novel technologies, based on the use of industrial natural by-pro- ducts obtained from fisheries and plant biomass will play a prominent role to produce new pro- ducts with added value for consumers. On the other hand, innovative nanocomposites made by natural polymers will be indispensable to reduce production and use of petrol-based plastic con- tainers, ranging today the $374-billion-a-year production! It is also to underline the necessity to really use the ~300 billion-year of biomass (from plant and fishery’s) which actually repre- sents an underutilized raw material. 20% of fishery's waste is used to make goods, while only 5% of plant biomass is used to produce energy! Interestingly have been also some unusual topics for a Dermatological meeting, which have been dedicated to the Cultural heritages, Patent protection and EU Cosmetic regulations respec- tively, with the idea necessary to enhance con- sumer protection and market development . It has been shown how Cultural heritages, R&D, and Innovation have to be considered the pillars of a sustainable progress, fundamental to main- tain the respect of both the human Health and the ecological environment, as evidenced in Piefrancesco Morganti’s presentation. By this point Antique Roman and Chinese Empires had the possibility to civilize Western and Eastern Countries respectively, having always in Mind to maintain mens sana in corpore sano (healthy brain into a healthy body). The cultural heritage has to remain at the basis of the progress. This is why China President, Xi Jinping, just during our meeting, remembered to Chinese the necessity to revive their own culture, according to the phi- losophic ideas and way of living of their ancient ancestor Confucius. Naturally, all the innovations recovered by research studies have to be patented to protect the intellectual properties of the inventor. This the interesting topic developed from dr. Claudio
Special Reports
3_Special Reports_Morganti_14 20/02/15 15:42 Pagina 133
Germinario, patent attorney of the Società Italiana Brevetti, Roma, Italy, active in this field from more than 10 years! Without entering in the meaning and explication of the intellectual property protection, it is interesting to remember that “Chinese law, like the European Patent Convention considers patentable not only medi- cines or active principles intended as chemical entities, but, more interestingly, their first, second and subsequent therapeutic applications. What the meaning? “Any substance although known in the prior art, having pharmacological activity or causing a pharmacological effect may be eligible for patent protection when it is fina- lized to a novel therapeutic application". About the rules governing the cosmetic pro- ducts, according to Sonia Selletti, known lawyer into the Studio Legale Astolfi e Associati, Milano, Italy, "the legislator has underlined the need to firm on a clear demarcation between cosmetics and similar health products (medici- nes, medical devices, biocides, food integrators) in an attempt to avoid overlapping classifica- tions relative to the so-called borderline situa- tions, so that the correct sector regulation can be identified". In any way "the function of cosmetics, being established at a legal level, leaves plenty of scope for research, development and innovation in terms of functions such as protection and maintenance onto which one may graft the most advanced cosmetic qualities that are in a posi- tion to establish said products as functional cosmetics, even if they are also recommended in other specific or complementary contexts such as therapeutic ones". These are just a few of the many other intere- sting topics presented during the two days mee- ting with more than 1,500 participants, young and expert scientists. At the closure of this interesting meeting, spe- cial awards were given to some young resear- chers also and the ISCD President, Prof. Hong-
Duo Chen, announced that the 2016 International meeting will be held in Jakarta, Indonesia.
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Fig. 1 The Venue of the 11th International Congress of Cosmetic Dermatology.
Fig. 3 The Opening Ceremony.
Fig. 5 Prof. Wei Liu.
Fig. 2 The Opening Ceremony.
Fig. 4 Attendees.
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Fig. 7 Prof. Hong-Duo Chen.
Fig. 9 Prof. Sewon Kang.
Fig. 11 Prof. Henry Lim.
Fig. 8 Prof. Pierfrancesco Morganti.
Fig. 10 Prof. Hong-Duo Chen, Prof. Pierfrancesco Morganti and Prof. Jianzhong Zhang chair the plenary lectures
Fig. 12 Prof Xing-Hua Gao.
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Fig. 17 The awarded certifications.
Fig. 15 Prof. Jianzhong Zhang awarded the speaker certification to Prof. Handog, pre- sident of International Society of Dermatology.
Fig. 13 One of the scientific session. Fig. 14 Dr. Claudio Germinario.
Fig. 16 The awarded certifications.
Fig. 18 Prof. Jianzhong Zhang closes the meeting.
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Fig. 23 Some speakers at dinner.
Fig. 20 Some of the speakers.
Fig. 21 Prof. Hong-Duo Chen, Prof. Pierfrancesco Morganti and Prof. Sheng-Quing Ma.
Fig. 19 Some of the speakers.
Fig. 22 Gala dinner.
Special Reports
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J. Appl. Cosmetol. 32, 131-138 (July/December 2014) Special Reports
131
In the wonderful setting of the magic city of Beijing, from September 26 to 28, 2014, was successfully held the 11th International Congress of Cosmetic Dermatology, organized by Chinese Society of Dermatology, Peking University People's Hospital No. 1, and China Medical University, under the auspices of International Society of Cosmetic Dermatology. There were 309 submissions included in the Congress proceedings, among them 135 papers were presented during the two-day events. After the introductory remarks reported from Wei Liu, Head of Dermatological Department, Air Force Hospital of Beijing, Ya-Fei Liu Deputy President of Chinese Medical Association, Hong-Duo Chen, President of International Society of Cosmetic Dermatology, Jian-Zhong Zhang, President of Chinese Society of Dermatology and Pierfrancesco Morganti, as Secretary General of the International Society of Cosmetic Dermatology the Meeting started by 5 Plenary Lectures which have opened a door for the Innovation in Horizon, where the green eco- nomy will be at the center of the future progress. Dozens of world renowned dermatologists and scientists presented on a variety of topics cove- ring laser treatment, usage of retinoic acid, skin rejuvenation, fillers, dermatologic surgery, photo-protection, antioxidant in cosmetic condi- tions, skin imaging and skin bioengineering, tra- ditional Chinese medicine in cosmetic dermato- logy, complications and pitfalls in cosmetic der- matology, et al. In addition, topics on cosmetic
regulation, impact of environmental pollutions on skin, view of beauty from East and West were also hotly discussed. Prof. Henry Lim from Henry Ford Medical System explained in details what’s new in photoprotection. Prof. Pierfrancesco Morganti, secretary general of International Society of Cosmetic Dermatology, outlined the bright future of deve- loping environmental friendly cosmetic pro- ducts. Prof. Evangeline Handog, president of International Society of Dermatology, stressed specifically the management of pigmentary alte- rations in acne. Prof. Sewon Kang from John Hopkins University presented the influence of epigenetics on skin aging. Prof. Jianzhong Zhang, Congress president and president of Chinese Society of Dermatology, discussed basic and specific classification of androgenetic alopecia and Chinese guideline for management of AGA. Prof. George Cotsarelis from University of Pennsylvinia introduced cellular and molecular understanding of androgenetic alopecia. Prof. Xing-Hua Gao, Congress presi- dent from China Medical University, displayed the treatment advances in recalcitrant vitiligo and vitiligo with prominent cosmetic conse- quences. Prof. Mark Pittelkow from Mayo Clinic, educated on the recent advances in scar- ring. The new concepts and new technologies in cosmetic dermatology were fully communicated during this congress. Stress, oxidants and pollu- tion at the base of many skin disorders, together
3_Special Reports_Morganti_14 20/02/15 15:42 Pagina 131
with the more modern therapeutic means used today to solve many pathologies affecting skin and hair, were reported and discussed by scien- tists coming from the main China, Japan, Philippines, South Korea, USA and Europe. Skin, in fact, serving as a barrier against all the external assaults is the potential target of the environmental oxidative stress, one of the major determinants in skin aging. Thus, when the natu- ral antioxidant defence mechanisms fail, or an increased flux of reactive oxidants from endo- and exogenous sources exceed the skin antioxi- dant capacity, oxidative injury will result. Oxidative stress, therefore, is referred to as a condition of imbalance of pro-oxidant/antioxi- dant equilibrium, in favour of the former. According to Achimichi Morita from Nagoya City a University, Japan, some epidemiologic studies have shown that water-soluble tobacco- smoking extract induced skin aging, the produc- tion of metalloproteinases (which degrade colla- gen), resulted increased as well as the hydrocar- bon receptors, which mediate the toxicity of several environmental contaminants were trig- gered. On the other hand, Umberto Cornelli, from Loyola University School of Medicine, Chicago, USA, has underlined the connection between the oxidative stress and the total chole- sterol, considered at the basis of hydroperoxide plasma levels. Moreover, according to Tie-Chi Lei, from Dermatological Department of Wuhan University, China, the oxidative stress, provoked from hydroquinone used as depigmenting agent, seems to be the main cause of the melanosome degradation, acting as a pro-oxidant agent. These studies open the door for the treatment of post inflammatory hyperpigmentation (PIH), a common sequelae of inflammatory Dermatoses, as shown in acne-affected patients, where a combination therapy is necessary, according to Evangeline B.Handog from Asian Hospital and Medical Center, Philippines, and Henry W Lim, from Dermatological Department of Henry Ford
Hospital, Detroit, USA. In the treatment of PIH, Lin has combined topical corticosteroids as mono therapy to monobenzyl ether of hydroqui- none, underlining how the chronic use of these ingredients can be cause of permanent depig- mentation, provoking vitiligo-like side effect. Vitiligo treatment has been the topic of Xing- Hua Gao, Department of Dermatology, No 1 Hospital of China Medical University, and Shenyang. He showed Interesting results obtai- ned on severe vitiligo-lesions on face, treated by calcineurin inhibitors and/or phototherapy. Unfortunately, vitiligo on hands and feet resul- ted very resistant to conventional treatments, while ablative laser-aided steroid delivery com- bined with UV-therapy irradiation seem to be the best promising therapy. Photodynamic and laser therapy, hypo and hyperpigmentary disorders and the use of stem cells, growth factors and new technologies to minimize the problem of keloids and improve the microenvironment or skin aging, were among all the more discussed topics. Nanobiotechnology, in fact, promises to revolu- tionise the use of biomolecular processes, at cell level by the development of new nanocomposi- tes and devices for biological and biomedical applications. Scientists, in fact, have harnessed the cell' ability to interact with other cells for developing new material with a living compo- nent. Restoration of aged skin and burned, wounded tissues are the possible applications by the use of advanced natural fibres entrapping active ingredients obtained from stem cells also, according to Yu Yanqiu, Department of Pathophysiology and Hangdeng Tu and Yuannhong Li, Department of Dermatology China Medical University of Shenyang. About the future of the cell therapy by stem cells, it has been underlined how some in progress studies aim to restore faith in the use of gene therapy of Primary immune deficiencies (PIDs) This study utilises genetically modified haemapoietic stem
Special Reports
3_Special Reports_Morganti_14 20/02/15 15:42 Pagina 132
cells' as a cell-based therapy for building a healthy immune system in patients with PIDs .In addition Marco Palombo, Burn Unit and Plastic Department, S. Eugenio Hospital, Rome, Italy, reported his personal experience on the utiliza- tion of new advanced medications made by a specialized nanocomposite tissue based on the use of Chitin Nanofibrils and plant polymers, entrapping active cicatrizing and antibacterial agents. The goal of this treatment on burned skin has been to obtain a complete reconstruction of the skin in a week maintaining the bandage in loco for all the period, without any kind of bac- terial invasion. Naturally, during the discussion it has been underlined how the use of new cosmetic pro- ducts of recognized high quality (based on the use on block-copolymer nanoparticles) and/or topical devices of new generation (obtained by the use of natural polymers and casting and elec- trospinning technologies) may represent innova- tive solutions for advanced medications and beauty masks for the treatment of photo-aged or precociously aged skin. In any way, all the pro- ducts have to be well regulated by the interna- tional laws to enhance the consumer protection, as well as to be also protected by patents to safe- guard the intellectual properties both of research and industry. Last but not least, there is a growing necessity to recognize that the transition to a green-bio-eco- nomy, based on the use of waste materials and bio-nano-technologies, consuming low quantity of water and energy, could generate a more sustainable growth. This new way of producing goods will address the decline/loss of ecosystem services, slowing down the increasing natural disasters, preserving the natural resources, and maintaining the biodiversity of the planet. For these reasons biotechnology will be an impor- tant pillar of Europe's economy by 2030 as well as of USA and China economy to meet the futu- re global challenge of a sustainable industry.
On one hand, medicine and novel technologies, based on the use of industrial natural by-pro- ducts obtained from fisheries and plant biomass will play a prominent role to produce new pro- ducts with added value for consumers. On the other hand, innovative nanocomposites made by natural polymers will be indispensable to reduce production and use of petrol-based plastic con- tainers, ranging today the $374-billion-a-year production! It is also to underline the necessity to really use the ~300 billion-year of biomass (from plant and fishery’s) which actually repre- sents an underutilized raw material. 20% of fishery's waste is used to make goods, while only 5% of plant biomass is used to produce energy! Interestingly have been also some unusual topics for a Dermatological meeting, which have been dedicated to the Cultural heritages, Patent protection and EU Cosmetic regulations respec- tively, with the idea necessary to enhance con- sumer protection and market development . It has been shown how Cultural heritages, R&D, and Innovation have to be considered the pillars of a sustainable progress, fundamental to main- tain the respect of both the human Health and the ecological environment, as evidenced in Piefrancesco Morganti’s presentation. By this point Antique Roman and Chinese Empires had the possibility to civilize Western and Eastern Countries respectively, having always in Mind to maintain mens sana in corpore sano (healthy brain into a healthy body). The cultural heritage has to remain at the basis of the progress. This is why China President, Xi Jinping, just during our meeting, remembered to Chinese the necessity to revive their own culture, according to the phi- losophic ideas and way of living of their ancient ancestor Confucius. Naturally, all the innovations recovered by research studies have to be patented to protect the intellectual properties of the inventor. This the interesting topic developed from dr. Claudio
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Germinario, patent attorney of the Società Italiana Brevetti, Roma, Italy, active in this field from more than 10 years! Without entering in the meaning and explication of the intellectual property protection, it is interesting to remember that “Chinese law, like the European Patent Convention considers patentable not only medi- cines or active principles intended as chemical entities, but, more interestingly, their first, second and subsequent therapeutic applications. What the meaning? “Any substance although known in the prior art, having pharmacological activity or causing a pharmacological effect may be eligible for patent protection when it is fina- lized to a novel therapeutic application". About the rules governing the cosmetic pro- ducts, according to Sonia Selletti, known lawyer into the Studio Legale Astolfi e Associati, Milano, Italy, "the legislator has underlined the need to firm on a clear demarcation between cosmetics and similar health products (medici- nes, medical devices, biocides, food integrators) in an attempt to avoid overlapping classifica- tions relative to the so-called borderline situa- tions, so that the correct sector regulation can be identified". In any way "the function of cosmetics, being established at a legal level, leaves plenty of scope for research, development and innovation in terms of functions such as protection and maintenance onto which one may graft the most advanced cosmetic qualities that are in a posi- tion to establish said products as functional cosmetics, even if they are also recommended in other specific or complementary contexts such as therapeutic ones". These are just a few of the many other intere- sting topics presented during the two days mee- ting with more than 1,500 participants, young and expert scientists. At the closure of this interesting meeting, spe- cial awards were given to some young resear- chers also and the ISCD President, Prof. Hong-
Duo Chen, announced that the 2016 International meeting will be held in Jakarta, Indonesia.
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Fig. 1 The Venue of the 11th International Congress of Cosmetic Dermatology.
Fig. 3 The Opening Ceremony.
Fig. 5 Prof. Wei Liu.
Fig. 2 The Opening Ceremony.
Fig. 4 Attendees.
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Fig. 7 Prof. Hong-Duo Chen.
Fig. 9 Prof. Sewon Kang.
Fig. 11 Prof. Henry Lim.
Fig. 8 Prof. Pierfrancesco Morganti.
Fig. 10 Prof. Hong-Duo Chen, Prof. Pierfrancesco Morganti and Prof. Jianzhong Zhang chair the plenary lectures
Fig. 12 Prof Xing-Hua Gao.
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Fig. 17 The awarded certifications.
Fig. 15 Prof. Jianzhong Zhang awarded the speaker certification to Prof. Handog, pre- sident of International Society of Dermatology.
Fig. 13 One of the scientific session. Fig. 14 Dr. Claudio Germinario.
Fig. 16 The awarded certifications.
Fig. 18 Prof. Jianzhong Zhang closes the meeting.
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Fig. 23 Some speakers at dinner.
Fig. 20 Some of the speakers.
Fig. 21 Prof. Hong-Duo Chen, Prof. Pierfrancesco Morganti and Prof. Sheng-Quing Ma.
Fig. 19 Some of the speakers.
Fig. 22 Gala dinner.
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