who collaborating centre for influenza - australia

WHO Collaborating Centre for WHO Collaborating Centre for Influenza - AustraliaInfluenza - Australia

Influenza in Australia 1992 - 2000Influenza in Australia 1992 - 2000

Laboratory Diagnosed Influenza - Australia 1992-2000

1 4 7 10 1 4 7 10 1 4 7 10 1 4 7 10 1 4 7 10 1 4 7 10 1 4 7 10 1 4 7 10 1 4 7 1092 93 94 95 96 97 98 99 00

0

200

400

600

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1000

Tota

l lab

orat

ory

diag

nose

s by

mon

th

TYPE A

TYPE B

0

10

20

30

40

Rat

e/10

00 c

onsu

ltatio

ns

1992

19941995 1996

1993

SENTINEL PRACTICE REPORTS

1997

1998

1999

2000

Influenza in New ZealandInfluenza in New Zealand

1 5 9 13 17 21 25 29 33 37 41 45 49Week 2000

0

5

10

15

20

25

30

35

Viru

s is

olat

es

Flu A Flu B

18 22 26 30 34 380100200300400500600700

Rat

e pe

r 100

,000

19961997199819992000

Monthly distribution of influenza isolatesThailand 2000

0

5

10

15

20

25

30

35

40

45

50

Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

BA(H3N2)

A(H1N1)

A(untyped)

Source of Virus Isolates Analysed Source of Virus Isolates Analysed Jan 2000 - Jan 2001Jan 2000 - Jan 2001

Australia

MalaysiaNew Caledonia

New Zealand

Philippines

Singapore

South Africa

Thailand

Taiwan

Vietnam

Distribution of Types/SubtypesDistribution of Types/SubtypesJan 2000 - Jan 2001Jan 2000 - Jan 2001

A(H3N2)

A(H1N1)

B

13.8%59.5%

26.8%

41.1%

36.8% 22.2%

53.1%

26.2% 20.7%

46.3%

41.5%12.2%

Australia New Zealand

OtherAsia

Influenza A(H1) Analysis Influenza A(H1) Analysis (1)(1)

ANTISERUMANTISERUMAA BB CC DD EE HumanHuman

Sera PoolSera PoolPassagePassageSampleSampleDateDate

REF. AgREF. Ag BAY/7BAY/7 JOH/82JOH/82 BEIJ/262BEIJ/262 SING/9SING/9 NC/20NC/20

AA A/BAYERN/7/95A/BAYERN/7/95 12801280 >2560>2560 2020 2020 2020 8080 X,E5X,E5BB A/JOH’BURG/82/96A/JOH’BURG/82/96 >2560>2560 >2560>2560 8080 8080 8080 320320 E4E4CC A/BEIJING/262/95A/BEIJING/262/95 2020 4040 640640 640640 320320 8080 E5E5DD A/SINGAPORE/9/98A/SINGAPORE/9/98 <20<20 <20<20 8080 8080 8080 4040 X,MD4X,MD4EE A/NEW CALEDONIA/20/99A/NEW CALEDONIA/20/99 <20<20 <20<20 4040 4040 160160 2020 E5E5

TEST AgTEST AgA/JOH’BURG/31/2000A/JOH’BURG/31/2000 <20<20 <20<20 8080 8080 640640 4040 XE2XE2B/VICTORIA/526/2000B/VICTORIA/526/2000 2020 2020 320320 320320 12801280 8080 MD2MD2 15.09.0015.09.00A/C’CHURCH/95/2000A/C’CHURCH/95/2000 2020 4040 160160 160160 320320 8080 MD3MD3 22.10.0022.10.00A/STH AUST/78/2000A/STH AUST/78/2000 2020 8080 320320 320320 640640 8080 MD2MD2 16.09.0016.09.00A/WELLINGTON/8/2000A/WELLINGTON/8/2000 4040 4040 320320 640640 12801280 160160 MDX,MD1MDX,MD1A/AUCKLAND/100/2000A/AUCKLAND/100/2000 4040 4040 320320 640640 12801280 160160 MD3MD3 29.08.0029.08.00A/STH AUST/157/2000A/STH AUST/157/2000 2020 4040 320320 320320 12801280 8080 MD2MD2 23.10.0023.10.00A/PERTH/256/2000A/PERTH/256/2000 2020 2020 160160 320320 640640 8080 MD2MD2 21.09.0021.09.00A/PERTH/266/2000A/PERTH/266/2000 2020 2020 320320 320320 640640 8080 MD2MD2 25.09.0025.09.00

Influenza A(H1) Analysis Influenza A(H1) Analysis (2)(2)

ANTISERUMANTISERUM

HumanHumanSera PoolSera Pool

PassagePassage SampleSampleDateDate

AA BB CC DD EE FF

REF. AgREF. Ag BAY/7BAY/7 JOH/82JOH/82 BEIJ/262BEIJ/262 SING/9SING/9 NC/20NC/20 FUJ/156FUJ/156

AAA/BAYERN/7/95A/BAYERN/7/95 12801280 >2560>2560 2020 2020 <20<20 <20<20 160160 X,E5X,E5BBA/JOH’BURG/82/96A/JOH’BURG/82/96 >2560>2560 >2560>2560 8080 4040 8080 2020 320320 E5E5CCA/BEIJING/262/95A/BEIJING/262/95 2020 8080 12801280 12801280 640640 320320 8080 E5E5DDA/SINGAPORE/9/98A/SINGAPORE/9/98 <20<20 <20<20 160160 160160 160160 160160 4040 X,MD4X,MD4EE A/NEW CAL/20/99A/NEW CAL/20/99 <20<20 <20<20 8080 640640 320320 640640 2020 E5E5FF A/FUJIAN/156/2000A/FUJIAN/156/2000 <20<20 2020 8080 160160 640640 12801280 4040 E2,E2,E1E2,E2,E1

TEST AgTEST AgA/PERTH/46/2000A/PERTH/46/2000 8080 8080 640640 12801280 >2560>2560 >2560>2560 160160 X,MD1X,MD1 16.10.0016.10.00A/BANGKOK/335/2000A/BANGKOK/335/2000 <20<20 <20<20 160160 160160 640640 12801280 8080 E3,MD1E3,MD1 29.08.0029.08.00A/H.K./1841/2000A/H.K./1841/2000 2020 2020 160160 160160 320320 320320 8080 C2,C2,MD1C2,C2,MD1A/TEXAS/87/2000A/TEXAS/87/2000 <20<20 2020 160160 160160 640640 640640 8080 M1,C2,MD1M1,C2,MD1A/TEXAS/90/2000A/TEXAS/90/2000 640640 >2560>2560 2020 2020 2020 2020 160160 M1,C2,MD1M1,C2,MD1A/WUHAN/292/2000A/WUHAN/292/2000 2020 8080 320320 320320 12801280 >2560>2560 160160 E2,E2,E1E2,E2,E1A/H.K./1924/2000A/H.K./1924/2000 <20<20 <20<20 160160 160160 640640 640640 8080 C2,C2,MD1C2,C2,MD1A/ENG/192/2000A/ENG/192/2000 8080 320320 8080 4040 160160 4040 160160 C2,E1,E3C2,E1,E3A/SING/37/2000A/SING/37/2000 <20<20 2020 160160 160160 640640 12801280 8080 MD3MD3 09.06.0009.06.00A/SING/44/2000A/SING/44/2000 <20<20 <20<20 8080 8080 320320 640640 8080 MD2MD2 24.10.0024.10.00A/PERTH/16/2000A/PERTH/16/2000 4040 8080 640640 640640 12801280 >2560>2560 160160 X,MD1X,MD1 04.09.0004.09.00A/PERTH/17/2000A/PERTH/17/2000 4040 4040 320320 640640 >2560>2560 >2560>2560 8080 X,MD1X,MD1 07.09.0007.09.00

Antigenic Analysis of A(H1N1) Antigenic Analysis of A(H1N1) IsolatesIsolates

A/Bayern14.4%

A/New Caledonia85.6%

A/Bayern4.2%

A/New Caledonia95.8%

Jan - Aug 2000 Sept 2000 - Jan 2001

0

8.4

2468

Brazil/231/00nimr [2/00]Sth Dakota/4/00cdc [12/00]Dakar/5/00nimr [7/00]Buenos Aries/R73/00nimr [6/00]

Neuquen/R79/00nimr [7/00]Bratislava/23/00nimr [12/00]Buenos Aries/R73/00nimr [7/00]

Texas/70/00cdc [11/00]Asuncion/1041/00nim r [10/00]

Dakar/13/00nimr [8/00]Berlin/127/00nimr [11/00]

Bratislava/28/00nimr [12/00]Dakar/17/00nimr [8/00]Iowa/4/00cdc [12/00]

Bangkok/34/00 [1/00]Auckland/3/00 [5/00]Mauritius/601/00nimr [5/00]

Bangkok/45/00 [1/00]Bangkok/196/00 [3/00]

Bangkok/2/00 [1/00]Johannesburg/14/00 [5/00]

Florida/8/00cdc [10/00]Singapore/5/00 [3/00]Guangdong/273/00cdc [8/00]Hong Kong/1799/00nimr [9/00]

Wuhan/292/00niid [9/00]Okinawa/159/00niidChristcurch/5/00 [6/00]Hong Kong/1379/00nimr [5/00]

Fujian/156/00cdc [8/00]Singapore/4/00 [3/00]

Henan/91/00cdc [9/00]Hong Kong/1924/00nimr [10/00]

Nagassaki/16/00niidSingapore/3/00 [3/00]Tennessee/5/00cdc [11/00]

Taiwan/8/00 [1/00]Finland/768/00nimr [11/00]

New Caledonia/20/99New Caledonia/13/00

Singapore/44/00 [10/00]Singapore/31/00 [5/00]

Miyagi/3/00New Caledonia/11/00

Beijing/262/95Hanoi/21/99

Taiwan/1/86Texas/36/91

Bayern/7/95Johannesburg/82/96

Sth Australia/8/00 [7/00]Sth Australia/27/00 [7/00]

Yokohama/24/00Yokohama/60/00

Chiba/389/00Florida/9/00cdc

Chile/4795/00cdc

GLU 120 GLXLYS 162 MET

VAL 165 ALA

ASP 186 ASN

Influenza A(H1N1) IsolatesHA1 Sequence Analysis

0

4.1

24

New Caledonia/18/88New Caledonia/11/00Miyagi/3/00

Johannesburg/13/00 [5/00]Bangkok/45/00 [1/00]Bangkok/195/00 [4/00]

Bangkok/34/00 [1/00]New Caledonia/20/99

Peru/1261/99cdcPeru/1798/99cdc

California/26/99cdcBeijing/262/95

Wuhan/371/95Yokohama/24/00

South Australia/8/00[7/00]South Australia/21/00 [7/00]

Johannesburg/82/96Texas/36/91

Influenza A(H1N1) IsolatesNA Sequence Analysis

Influenza A(H3) AnalysisInfluenza A(H3) Analysis

ANTISERUMANTISERUMAA BB CC DD EE FF HumanHuman

Sera PoolSera PoolPassagePassage SampleSample

DateDateREF. AgREF. Ag SYD/5SYD/5 MOS/10MOS/10 PAN/2007PAN/2007 TEHRANTEHRAN SYD/203SYD/203 ULANULAN

AA A/SYDNEY/5/97A/SYDNEY/5/97 640640 640640 640640 640640 12801280 640640 8080 CEK2,E5CEK2,E5BB A/MOSCOW/10/99A/MOSCOW/10/99 320320 >2560>2560 640640 640640 12801280 12801280 160160 E7E7CC A/PANAMA/2007/99A/PANAMA/2007/99 8080 4040 640640 160160 160160 640640 4040 E7E7DD A/TEHRAN/14/99A/TEHRAN/14/99 160160 640640 640640 12801280 12801280 12801280 8080 X2,E3X2,E3EE A/SYDNEY/203/2000A/SYDNEY/203/2000 640640 12801280 640640 640640 >2560>2560 12801280 8080 E4E4FF A/ULAN/UDE/01/2000A/ULAN/UDE/01/2000 320320 8080 320320 640640 320320 12801280 8080 E6E6

TEST AgTEST AgA/VICTORIA/346/2000A/VICTORIA/346/2000 320320 12801280 640640 640640 640640 640640 160160 X,MD1X,MD1A/WELLINGTON/13/2000A/WELLINGTON/13/2000 8080 320320 320320 320320 320320 320320 4040 MDX,MD1MDX,MD1A/WAIKATO/7/2000A/WAIKATO/7/2000 640640 12801280 640640 12801280 12801280 12801280 8080 MDX,MD1MDX,MD1A/WAIKATO/10/2000A/WAIKATO/10/2000 320320 12801280 12801280 12801280 >2560>2560 12801280 160160 MEKX,MD1MEKX,MD1A/WAIKATO/14/2000A/WAIKATO/14/2000 640640 12801280 12801280 12801280 >2560>2560 >2560>2560 320320 MDX,MD1MDX,MD1A/WAIKATO/15/2000A/WAIKATO/15/2000 320320 640640 640640 640640 640640 640640 8080 MEKX,MD1MEKX,MD1A/WAIKATO/17/2000A/WAIKATO/17/2000 4040 160160 8080 160160 8080 8080 <20<20 MEKX,MD1MEKX,MD1A/STH AUST/101/2000A/STH AUST/101/2000 4040 160160 160160 160160 160160 160160 2020 MDX,MD1MDX,MD1 28.09.0028.09.00A/STH AUST/136/2000A/STH AUST/136/2000 160160 640640 640640 12801280 12801280 320320 4040 MDX,MD1MDX,MD1 11.10.0011.10.00A/BRISBANE/71/2000A/BRISBANE/71/2000 8080 160160 160160 160160 160160 160160 <20<20 MDX,MD1MDX,MD1 20.09.0020.09.00A/BRISBANE/72/2000A/BRISBANE/72/2000 8080 640640 640640 640640 12801280 320320 4040 MDX,MD1MDX,MD1 23.09.0023.09.00A/BRISBANE/75/2000A/BRISBANE/75/2000 8080 160160 160160 320320 320320 320320 2020 MDX,MD1MDX,MD1 03.10.0003.10.00

Antigenic Analysis of A(H3N2) Antigenic Analysis of A(H3N2) IsolatesIsolates

A/Sydney5.9%

A/Sydney (low)12.3%

A/Moscow67.8%

A/Moscow (low)14.0%

A/Moscow62.5%

A/Moscow (low)37.5%

Jan - Aug 2000 Sept 2000 - Jan 2001

HA H3N2

0

10.5

246810

Christchurch/85/00 [9/00]Victoria/557/00 [9/00]

Sth Australia/71/00 [8/00]Victoria/564/00 [10/00]

Sydney/274/00 [9/00]Perth/243/00 [9/00]

California/9/00 [10/00]Sth Australia/87/00 [9/00]Townsville/7/00 [9/00]Sydney/217/00 [8/00]Hong Kong/1923/00nimrDarwin/10/00 [10/00]Brisbane/71/00 [9/00]

Christchurch/39/00 [8/00]Perth/10/00 [8/00]

Fujian/140/00cdc [7/00]Sydney/213/00 [8/00]

Victoria/570/00 [11/00]Guangzhou/483/00niid

Sydney/221/00 [8/00]Guandong/233/00cdc [6/00]

Hong Kong/28278/00nimr [9/00]Sydney/203/00 [5/00]

A/Panama/2007/99Argentina/5995/00cdc [10/00]

CRica/2/00cdc [7/00]Singapore/2/00 [3/00]Johannesburg/50/00saBrisbane/37/00 [9/00]

Christchurch/80/00 [9/00]Ulan Ude/01/00Victoria/509/00 [7/00]

A/Tehran/14/99Taiwan/3/00 [1/00]Perth/1/00 [3/00]

Wellington/58/00 [9/00]Brisbane/7/00 [6/00]

Townsville/4/00 [8/00]New Caledonia/7/00 [7/00]

Victoria/555/00 [9/00]Christchurch/94/00 [10/00]

India/3783/00cdc [7/00]Singapore/63/00 [11/00]Darwin/1/00 [5/00]

A/Moscow/10/99Bangkok/62/00 [2/00]

A/Sydney/5/97A/Sth Africa/1147/96

A/Wuhan/359/95A/Johannesburg/33/94

Guangdong/183/00niidA/Nanchang/933/95

ARG 50 GLYSER 199 PROSER 247 CYSPRO 273 SER

GLY 5 VALGLU 33 HISLYS 92 THRASN 144 ILEASP 271 ASN

Influenza A(H3N2) IsolatesHA1 Sequence Analysis

0

4.0

2

Tehran/14/99Brisbane/32/00 [9/00]

Bangkok/62/00 [2/00]Darwin/6/00 [10/00]

Townsville/7/00 [9/00]Victoria/564/00 [10/00]

Malaysia/41/99Christchurch/3/00

Ulan Ude/1/00Perth/213/00 [2/00]Sydney/201/00 [2/00]Darwin/1/00 [5/00]

Victoria/572/99Sydney/203/00 [5/00]

Victoria/1/99Perth/1/00 [3/00]

Victoria/522/99Moscow/10/99

Sth Australia/1/00 [1/00]Bangkok/140/00 [3/00]

Ulan Ude/2/99cdcShanghai/42/99cdc

Brisbane/65/99Hong Kong/4867/98cdcPanama/2007/99

Alaska/22/99cdcChile/5049/99cdc

Malaysia/5/99Sichuan/346/98

Connecticut/5/99cdcSydney/5/97

Wuhan/359/95Nanchang/933/95

Johannesburg/32/94

Influenza A(H3N2) IsolatesNA Sequence Analysis

Influenza B Analysis (1)Influenza B Analysis (1)ANTISERUMANTISERUM

AA BB CC DD EE FF GG

BEIJ/184BEIJ/184 YAM/166YAM/166 SHEN/654SHEN/654 SICH/379SICH/379 B/JOH/5B/JOH/5 AUCK/1AUCK/1 JOH/45JOH/45 PASSAGEPASSAGE SAMPLESAMPLE DATEDATEREF. AgREF. Ag

AA B/BEIJING/184/93B/BEIJING/184/93 320320 320320 2020 12801280 320320 320320 640640 E10E10

BB B/YAMANASH/166/98B/YAMANASH/166/98 320320 640640 4040 >2560>2560 640640 640640 640640 E10E10

CC B/SHENZHEN/654/99B/SHENZHEN/654/99 4040 4040 320320 160160 160160 160160 160160 E8E8

DD B/SICHUAN/379/99B/SICHUAN/379/99 160160 160160 2020 640640 160160 160160 160160 E11E11

EE B/JOHANNESBURG/5/99B/JOHANNESBURG/5/99 160160 160160 2020 12801280 320320 160160 640640 E5E5

FF B/AUCKLAND/1/2000B/AUCKLAND/1/2000 320320 160160 <20<20 320320 160160 320320 320320 CEK1E4CEK1E4

GG B/JOHANNESBURG/45/99B/JOHANNESBURG/45/99 160160 160160 2020 640640 160160 160160 320320 E8E8

TEST AgTEST Ag

B/VICTORIA/525/2000B/VICTORIA/525/2000 160160 4040 160160 320320 320320 160160 320320 MD2MD2 13.09.0013.09.00

B/CHRISTCHURCH/9/2000B/CHRISTCHURCH/9/2000 8080 2020 160160 320320 160160 160160 160160 MD3MD3 30.08.0030.08.00

B/CHRISTCHURCH/7/2000B/CHRISTCHURCH/7/2000 160160 4040 160160 640640 640640 320320 640640 MD2MD2 16.08.0016.08.00

B/VICTORIA/733/2000B/VICTORIA/733/2000 160160 2020 160160 160160 320320 160160 160160 MD2MD2 22.08.0022.08.00

B/VICTORIA/741/2000B/VICTORIA/741/2000 8080 4040 160160 320320 320320 160160 320320 MD2MD2 05.09.0005.09.00

B/VICTORIA/1/2000B/VICTORIA/1/2000 160160 4040 160160 640640 640640 640640 640640 MD1MD1

B/SHANGHAI/72/99B/SHANGHAI/72/99 160160 160160 2020 640640 320320 160160 320320 E5E5

B/MEXICO/84/2000B/MEXICO/84/2000 160160 8080 4040 640640 320320 160160 320320 E5E5

B/MADAGASCAR/50212/99B/MADAGASCAR/50212/99 8080 160160 2020 640640 160160 8080 320320 E6E6

Influenza B Analysis (2)Influenza B Analysis (2)

ANTISERUMANTISERUM

PASSAGEPASSAGEAA BB CC DD EE

BEIJ/184BEIJ/184 YAM/166YAM/166 SICH/379SICH/379 B/JOH/5B/JOH/5 VIC/504VIC/504REF. AgREF. Ag

AAB/BEIJING/184/93B/BEIJING/184/93 320320 320320 640640 640640 320320 E10E10BBB/YAMANASH/166/98B/YAMANASH/166/98 320320 320320 12801280 320320 160160 E11E11CCB/SICHUAN/379/99B/SICHUAN/379/99 160160 160160 640640 320320 320320 E9E9DDB/JOHANNESBURG/5/99B/JOHANNESBURG/5/99 320320 320320 12801280 320320 320320 E5E5EEB/VICTORIA/504/2000B/VICTORIA/504/2000 8080 <20<20 160160 160160 320320 CEK1E1CEK1E1

TEST AgTEST AgB/C’CHURCH/22/2000B/C’CHURCH/22/2000 160160 4040 640640 320320 640640 MD3MD3 02.10.0002.10.00B/VICTORIA/114/2000B/VICTORIA/114/2000 160160 8080 640640 320320 640640 MDX,MD1MDX,MD1 26.09.0026.09.00B/VICTORIA/107/2000B/VICTORIA/107/2000 160160 2020 320320 160160 320320 MKX,MD1MKX,MD1 16.08.0016.08.00B/WELLINGTON/21/2000B/WELLINGTON/21/2000 160160 4040 640640 320320 640640 MD2MD2 27.09.0027.09.00B/BRISBANE/30/2000B/BRISBANE/30/2000 160160 4040 640640 320320 640640 MDX,MD1MDX,MD1 19.09.0019.09.00B/BRISBANE/38/2000B/BRISBANE/38/2000 320320 8080 640640 320320 320320 MDX,MD1MDX,MD1 25.09.0025.09.00B/STH AUST/85/2000B/STH AUST/85/2000 8080 <20<20 160160 160160 320320 MDX,MD1MDX,MD1 07.09.0007.09.00B/STH AUST/86/2000B/STH AUST/86/2000 8080 2020 320320 160160 320320 MDX,MD1MDX,MD1 07.09.0007.09.00B/VICTORIA/321/2000B/VICTORIA/321/2000 8080 <20<20 320320 160160 640640 X,MD1X,MD1 12.09.0012.09.00

SAMPLESAMPLE DATEDATE

B/Shangdong6.7%

B/Beijing90.5%

B/Sichuan2.9%

B/Beijing60.3%

B/Sichuan39.7%

Antigenic Analysis of Type B Antigenic Analysis of Type B IsolatesIsolates

Jan - Aug 2000 Sept 2000 - Jan 2001

0246

ALA 28 VALARG 69 SERALA 127 ILELYS 149 ARG

7.9

Brisbane/4/00 [8/00]Sth Australia/24/00 [7/00]

Victoria/541/00 [10/00]California/6/00cdc [11/00]

Canada/16188/00cdc [11/00]Washington/3/00cdc [12/00 ]

Victoria/520/00 [9/00]Victoria/529/00 [9/00]

New York/2/00cdc [12/00]Sth Australia/47/00 [8/00]Hong Kong/548/00nimr [9/00]

Sydney/217/00 [8/00]Hong Kong/564/00nimr [10/00]

Johannesburg/5/99Moscow/4/00nimr [4/00]

Buenos Aries/R64/00nimr [6/00]Hong Kong/533/00nimr [6/00]Victoria/502/00 [7/00]

Shizuoka/480/00niidVictoria/504/00 [8/00]

Sichuan/379/99Washington/2/00cdc [9/00]

Sth Australia/5/99Christchurch/5/00 [7/00]

Lisbon/3/00nimr [10/00]Alaska/16/00cdc [11/00]

Sendai/H518/00cdcSydney/201/00 [7/00]

Gaungdong/120/00cdc [3/00]Perth/2/00 [5/00]Victoria/527/00 [9/00]

Brazil/975/00cdcAuckland/3/00 [6/00]

Perth/1/00 [2/00]Bangkok/29/00 [ 1/00]Singapore/25/00 [8/00]

Osako/C-1/00Victoria/503/00 [8/00]Argentina/113/00cdc [ 8/00]

Yamanshi/166/98Hong Kong/557/00cdc [10/00]

Taiwan/2/00 [3/00]Shenzhen/654/99

Philippines/289/00 [5/00]Hong Kong/588/00cdc [10/00]

Beijing/184/93Harbin/7/94

Beijing/243/97Shangdong/7/97

LYS 58 PHEASN 126 ASP

ASN 196 ASPASP 232 GLU

ILE 87 VALLYS 88 ARG

Influenza B IsolatesHA1 Sequence Analysis

0

3.7

2

Shanghai/75/99cdcShanghai/72/99

Sichuan/379/99Christchurch/2/00[7/00]

Perth/2/00 [5/00]Victoria/311/00 [8/00]/Victoria/527/00 [9/00]

Johannesburg/5/99Sth Australia/5/99

Bucharest/311/98cdcVictoria/504/00 [8/00]

Perth/1/00 [2/00]Auckland/1/00 [5/00]

Bangkok/11/00 [1/00]Yamanashi/166/98

Harbin/7/97Beijing/184/93

Panama/45/90Bangkok/34/99

Sichuan/40/99cdcShangdong/7/97Beijing/243/97

Bangkok/54/99cdc/Victoria/2/87

Influenza B IsolatesNA Sequence Analysis

New Cal/20/99

Auck/32/2000

Joh/82/96

Texas/87/2000

Wuhan/292/2000

USA GMT USA >40 Aust GMT Aust >400

100

200

300

400

Influenza Type A(H1N1) VaccineResponses - Older Adults 2000

Influenza Type A(H3N2) VaccineInfluenza Type A(H3N2) VaccineResponses - Older Adults 2000Responses - Older Adults 2000

USA GMT USA >40 Aust GMT Aust >400

20

40

60

80

100

120

140

160

Sydney/5/97

Panama/2007/99

Tehran/14/99

Sydney/203/2000

Ulan Ude/1/2000

VBrazil/991/2000

Fujian/40/2000

Hong Kong/1923/2000

Lyon/1242/2000

Influenza Type B VaccineInfluenza Type B VaccineResponses - Older Adults 2000Responses - Older Adults 2000

Yamanashi/166/98Joh/5/99Sichuan/379/99Auckland/1/2000Christchurch/2/2000Zagreb/3578/99Victoria/504/2000Alaska/16/2000Series 9

USA GMT USA >40 Aust GMT Aust >400

20

40

60

80

100

120