the synthetic bone company angstrom medica, inc. 150-a new boston street woburn, ma 01801...

The Synthetic Bone Company™

Angstrom Medica, Inc. 150-A New Boston Street Woburn, MA 01801 781.933.6121 www.angstrommedica.com

Utilizing Nanotechnology

to

Develop Medical Devices

Edward S. Ahn, Ph.D.

Angstrom Medica, Inc. - Proprietary and Confidential

Why Nanotechnology?

All interactions occur at an interface

Maximize interactions by maximizing interface

Increase surface area to volume ratio

Unique size dependent properties

Angstrom Medica, Inc. - Proprietary and Confidential

Nanotechnology and the Medical Device

PhysicianInput

ProductDefinition

RegulatoryApproval

Manufacturing Sales

Does nanotechnologysolve a compelling

clinical need?

510(k) or PMA?

Can you make it?

FINANCING

Do the potential rewards out weigh risks?

Angstrom Medica, Inc. - Proprietary and Confidential

Defining The Product

Compelling Clinical Need What kind of product?

Incremental product improvementRevolutionary procedure

IssuesTechnology looking for a homeHow do clinicians contextualize nanotechnology?Are there more conventional alternatives?

Angstrom Medica, Inc. - Proprietary and Confidential

Angstrom’s ProductsSpinal Fusion Devices Angstromplasty

Hip Fracture Prevention

100 nm100 nm

Bone Screws

Angstrom Medica, Inc. - Proprietary and Confidential

FDA Approval

Same but different strategy First nanomedical device approved by FDA

Nanocrystalline CaP bone void filler

Incremental product improvement Should be 510(k)

Bone screws and spinal fusion devices

Revolutionary Procedure May require clinical trials

Angstromplasty

Angstrom Medica, Inc. - Proprietary and Confidential

Manufacturing

Nanotechnology = Expensive? InfrastructureSpecialized talentMulti-step processingLimited outsourcingReproducibility and Reliability

Nanotechnology is stochastic

Angstrom Medica, Inc. - Proprietary and Confidential

Angstrom’s Manufacturing Process

100 nm

Precipitation Forging Machining

Angstrom Medica, Inc. - Proprietary and Confidential

Financing

Grants Angel Investors Strategic Partners Institutional Investors

Technical Risk Marketing Risk Execution Risk

engineering small miracles™

Angstrom Medica, Inc. 150-A New Boston Street Woburn, MA 01801 781.933.6121 www.angstrommedica.com