the mrf genome library: epidemiology of meningococcal disease-causing lineages in england and wales...

The MRFMeningococcus Genome Librarywww.meningitis.org/research/genome

Dorothea HillUniversity of Oxford

MRF conference 2013Wednesday 6th November

‘Publicly accessible data requires a stable home and someone to pay the mortgage.’ Dr. Francine Berman, Research Data Alliance

MRU: Isolates

Illumina genome sequencing

BIGS databasehttp://pubmlst.org

Funding

Whole-genome population structure with ‘Genome Comparator’: two CC269 (lineage 2) sub-lineages.

100 locilineage 5 (CC32)

lineage 2.2Incl. ST-275, ST-1161 lineage 2.1

Incl. ST-269, ST-467, ST-283

261 loci

451 loci

Community improvement of the MRF Genome Library.

dorothea.hill@zoo.ox.ac.uk

Jolley, K. and M. Maiden, Automated extraction of typing information for bacterial pathogens from whole genome sequence data: Neisseria meningitidis as an exemplar. Euro Surveill, 2013.

Meningococcal Reference Unit:Ray Borrow, Jay Lucidarme, Steve Gray

Pathogen genomics:Julian Parkhill, David Harris

Maiden Group: Martin Maiden, Keith Jolley, James Bray